isoquercitrin has been researched along with Autistic-Disorder* in 1 studies
1 other study(ies) available for isoquercitrin and Autistic-Disorder
| Article | Year |
|---|---|
Ameliorating effect of continuous alpha-glycosyl isoquercitrin treatment starting from late gestation in a rat autism model induced by postnatal injection of lipopolysaccharides.
The present study investigated the role of neuroinflammation and brain oxidative stress induced by neonatal treatment with lipopolysaccharides (LPS) on the development of autism spectrum disorder (ASD)-like behaviors and disruptive hippocampal neurogenesis in rats by exploring the chemopreventive effects of alpha-glycosyl isoquercitrin (AGIQ) as an antioxidant. AGIQ was dietary administered to dams at 0.25% or 0.5% (w/w) from gestational day 18 until postnatal day (PND) 21 on weaning and then to pups until the adult stage on PND 77. The pups were intraperitoneally injected with LPS (1 mg/kg body weight) on PND 3. At PND 6, LPS alone increased Iba1 Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Antioxidants; Autistic Disorder; Dentate Gyrus; Female; Gene Expression; Glycosides; Lipopolysaccharides; Male; Neurogenesis; Neuroinflammatory Diseases; Neuroprotective Agents; Open Field Test; Oxidative Stress; Pregnancy; Quercetin; Rats, Sprague-Dawley; Social Interaction | 2022 |