isoproterenol and Sepsis studies

Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.

Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Research Excerpts

Excerpt	Relevance	Reference
"Recent findings in human septic shock suggest that glucocorticosteroids can limit and even reverse hemodynamic disturbances and dependence on catecholamines."	1.32	Hemodynamic effects of early versus late glucocorticosteroid administration in experimental septic shock. ( Bollaert, PE; Levy, B; Longrois, D; Mallié, JP; Mansart, A; Seguin, C, 2003)
"Sepsis was induced by cecal ligation and puncture (CLP)."	1.31	Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis. ( Liu, MS; Tang, C; Wu, LL, 2001)
"Sepsis was induced by cecal ligation and puncture (CLP)."	1.29	Externalization and internalization of (Na+ + K+)-ATPase in rat heart during different phases of sepsis. ( Chen, XY; Hsu, HK; Liu, MS; Tang, C, 1993)
"With early trauma, beta-adrenergic responsiveness and receptor number were significantly decreased."	1.27	Adrenergic control of adipocyte lipolysis in trauma and sepsis. ( Askanazi, J; Forse, RA; Hirsch, J; Kinney, JM; Leibel, R, 1987)

Timeframe	Studies, this research(%)	All Research%
pre-1990	31 (75.61)	18.7374
1990's	4 (9.76)	18.2507
2000's	4 (9.76)	29.6817
2010's	2 (4.88)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Hoover, DB	1
Ozment, TR	1
Wondergem, R	1
Li, C	1
Williams, DL	1
Ha, YM	1
Ham, SA	1
Kim, YM	1
Lee, YS	1
Kim, HJ	1
Seo, HG	1
Lee, JH	1
Park, MK	1
Chang, KC	1
Mansart, A	1
Bollaert, PE	1
Seguin, C	1
Levy, B	1
Longrois, D	1
Mallié, JP	1
MACLEAN, LD	2
DUFF, JH	2
SCOTT, HM	1
PERETZ, DI	1
Zorn-Pauly, K	1
Pelzmann, B	1
Lang, P	1
Mächler, H	1
Schmidt, H	1
Ebelt, H	1
Werdan, K	1
Koidl, B	1
Müller-Werdan, U	1
Siegel, JH	2
Greenspan, M	1
Del Guercio, LR	2
Carey, JS	1
Brown, RS	1
Mohr, PA	1
Monson, DO	1
Yao, ST	1
Shoemaker, WC	1
Loeb, HS	2
Cruz, A	1
Teng, CY	1
Boswell, J	1
Pietras, RJ	1
Tobin, JR	1
Gunnar, RM	2
Artman, M	1
Graham, TP	1
Tang, C	2
Hsu, HK	1
Chen, XY	1
Liu, MS	2
Piper, RD	1
Li, FY	1
Myers, ML	1
Sibbald, WJ	1
Abi-Gerges, N	1
Tavernier, B	1
Mebazaa, A	1
Faivre, V	1
Paqueron, X	1
Payen, D	1
Fischmeister, R	1
Méry, PF	1
Wu, LL	1
Rosas, GO	1
Zieman, SJ	1
Donabedian, M	1
Vandegaer, K	1
Hare, JM	1
Foy, T	1
Marion, J	1
Brigham, KL	1
Harris, TR	1
Seneca, H	2
Grant, JP	1
McDonough, KH	2
Burke, EC	1
Smith, LW	2
Forse, RA	1
Leibel, R	1
Askanazi, J	1
Hirsch, J	1
Kinney, JM	1
Liu, YL	1
Smits, H	1
Freedman, LR	1
Wolff, G	1
Gigon, JP	1
Enderlin, F	1
Mirouze, J	1
Mion, C	1
Roquefeuil, B	1
Wilmore, DW	1
Long, JM	1
Mason, AD	1
Skreen, RW	1
Pruitt, BA	1
Marshall, BR	1
Hepler, JK	1
Jinguji, MS	1
Mokgokong, ET	1
Jenkins, WL	1
Winslow, EJ	1
Rahimtoola, SH	1
Kamath, S	1
Weil, MH	1
Shubin, H	1
Lambotte, L	1
Rocmans, P	1
Mulligan, GW	1
McLean, AP	1
Blair, E	1
Wise, A	1
Mackay, AG	1
Motsay, GJ	1
Dietzman, RH	1
Ersek, RA	1
Lillehei, RC	1
Sugerman, HJ	1
Diaco, JF	1
Pollock, TW	1
Miller, LD	1
Marston, A	1
Romney, SL	1
Schulman, H	1
Goldwyn, RM	1
Schwimmer, D	1
Johnson, DG	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
"Reducing Elevated Heart Rate in Patients With Multiple Organ Dysfunction Syndrome (MODS) by the Funny Channel Current (If) Inhibitor Ivabradine"[NCT01186783]			Phase 2	70 participants (Anticipated)	Interventional	2010-05-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Congestive heart failure in infancy: recognition and management. American heart journal, 1982, Volume: 103, Issue:6 Topics: Acute Kidney Injury; Airway Obstruction; Anemia, Hemolytic; Arteriovenous Fistula; Asphyxia Neonator	1982
In vitro cardiac function in early sepsis. Journal of medicine, 1990, Volume: 21, Issue:1-2 Topics: Animals; Bacterial Infections; Catecholamines; Compliance; Heart; Isoproterenol; Myocardial Contract	1990

Article	Year
Impaired heart rate regulation and depression of cardiac chronotropic and dromotropic function in polymicrobial sepsis. Shock (Augusta, Ga.), 2015, Volume: 43, Issue:2 Topics: Adrenergic beta-Agonists; Adrenergic Uptake Inhibitors; Animals; Coinfection; Disease Models, Animal	2015
β₁-adrenergic receptor-mediated HO-1 induction, via PI3K and p38 MAPK, by isoproterenol in RAW 264.7 cells leads to inhibition of HMGB1 release in LPS-activated RAW 264.7 cells and increases in survival rate of CLP-induced septic mice. Biochemical pharmacology, 2011, Oct-01, Volume: 82, Issue:7 Topics: Animals; Cecum; Cell Line; Constriction, Pathologic; Heme Oxygenase-1; HMGB1 Protein; I-kappa B Kina	2011
Hemodynamic effects of early versus late glucocorticosteroid administration in experimental septic shock. Shock (Augusta, Ga.), 2003, Volume: 19, Issue:1 Topics: Adrenergic alpha-Agonists; Animals; Catecholamines; Cyclic AMP; Dexamethasone; Dose-Response Relatio	2003
TREATMENT OF SHOCK IN MAN BASED ON HEMODYNAMIC DIAGNOSIS. Surgery, gynecology & obstetrics, 1965, Volume: 120 Topics: Blood; Blood Gas Analysis; Blood Pressure; Blood Pressure Determination; Blood Transfusion; Blood Vo	1965
Endotoxin impairs the human pacemaker current If. Shock (Augusta, Ga.), 2007, Volume: 28, Issue:6 Topics: Adult; Aged; Cells, Cultured; Electrophysiology; Female; Heart Rate; Humans; Ion Channels; Isoproter	2007
Abnormal vascular tone, defective oxygen transport and myocardial failure in human septic shock. Annals of surgery, 1967, Volume: 165, Issue:4 Topics: Adult; Blood Flow Velocity; Blood Gas Analysis; Blood Pressure; Blood Vessels; Blood Volume; Cardiac	1967
Cardiovascular function in shock. Responses to volume loading and isoproterenol infusion. Circulation, 1967, Volume: 35, Issue:2 Topics: Adolescent; Adult; Aged; Blood Pressure; Blood Volume; Cardiac Output; Catecholamines; Dextrans; Fem	1967
Haemodynamic studies in shock associated with infection. British heart journal, 1967, Volume: 29, Issue:6 Topics: Aged; Blood Pressure; Blood Volume; Cardiac Output; Chlorpromazine; Dextrans; Digitalis Glycosides;	1967
Externalization and internalization of (Na+ + K+)-ATPase in rat heart during different phases of sepsis. Circulatory shock, 1993, Volume: 41, Issue:1 Topics: Adenosine Triphosphate; Affinity Labels; Animals; Azides; Binding, Competitive; Dihydroalprenolol; G	1993
Effects of isoproterenol on myocardial structure and function in septic rats. Journal of applied physiology (Bethesda, Md. : 1985), 1999, Volume: 86, Issue:3 Topics: Adrenergic beta-Agonists; Animals; Blood Cell Count; Blood Pressure; Coronary Circulation; Heart; He	1999
Sequential changes in autonomic regulation of cardiac myocytes after in vivo endotoxin injection in rat. American journal of respiratory and critical care medicine, 1999, Volume: 160, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl	1999
Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis. American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 281, Issue:2 Topics: Adenosine Triphosphatases; Adrenergic beta-Agonists; Animals; Biomarkers; Calcium; Cardiac Myosins;	2001
Augmented age-associated innate immune responses contribute to negative inotropic and lusitropic effects of lipopolysaccharide and interferon gamma. Journal of molecular and cellular cardiology, 2001, Volume: 33, Issue:10 Topics: Adrenergic beta-Agonists; Age Factors; Aging; Animals; Arginine; Blotting, Western; Citrulline; Cycl	2001
Isoproterenol and aminophylline reduce lung capillary filtration during high permeability. Journal of applied physiology: respiratory, environmental and exercise physiology, 1979, Volume: 46, Issue:1 Topics: Aminophylline; Animals; Blood Pressure; Blood Proteins; Capillary Permeability; Female; Heart Atria;	1979
Gram-negative sepsis: part II. Management. Comprehensive therapy, 1977, Volume: 3, Issue:8 Topics: Acidosis; Adult; Amikacin; Child; Chloramphenicol; Clindamycin; Disseminated Intravascular Coagulati	1977
Glucocorticoid therapy in sepsis/shock caused by gram-negative microorganisms. Journal of the American Geriatrics Society, 1975, Volume: 23, Issue:11 Topics: Ampicillin; Carbenicillin; Cefazolin; Cephalothin; Dexamethasone; Endotoxins; Gentamicins; Glucocort	1975
Inotropic sensitivity to beta-adrenergic stimulation in early sepsis. The American journal of physiology, 1988, Volume: 255, Issue:4 Pt 2 Topics: Animals; Blood Pressure; Cardiac Output; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Myoca	1988
Adrenergic control of adipocyte lipolysis in trauma and sepsis. Annals of surgery, 1987, Volume: 206, Issue:6 Topics: Adipose Tissue; Adult; Aged; Clonidine; Energy Metabolism; Female; Humans; Isoproterenol; Lipolysis;	1987
Editorial: Bacteraemic shock. Lancet (London, England), 1974, Feb-23, Volume: 1, Issue:7852 Topics: Bacteria; Bacterial Infections; Dopamine; Humans; Isoproterenol; Norepinephrine; Sepsis; Shock, Sept	1974
[Isoproterenol in the treatment of fulminating meningococcemia in children complicated by shock. An analysis of 181 cases]. Zhonghua yi xue za zhi, 1974, Issue:12 Topics: Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Isoproterenol; Male; Meningococcal	1974
Prolonged venous catheterization as a cause of sepsis. The New England journal of medicine, 1967, Jun-01, Volume: 276, Issue:22 Topics: Aged; Catheterization; Chloramphenicol; Clostridium perfringens; Colistin; Dextrans; Enterobacter; E	1967
[Shock therapy with vasodilator and-or vasoconstrictor agents]. Helvetica chirurgica acta, 1967, Volume: 34, Issue:1 Topics: Adult; Aged; Angiotensin II; Blood Pressure; Diuresis; Female; Humans; Isoproterenol; Norepinephrine	1967
[Massive corticotherapy in the treatment of septicemic collapse]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1969, May-20, Volume: 45, Issue:24 Topics: Adult; Aged; Blood Volume; Cortisone; Fever; Humans; Hydrocortisone; Isoproterenol; Kidney Failure,	1969
Catecholamines: mediator of the hypermetabolic response to thermal injury. Annals of surgery, 1974, Volume: 180, Issue:4 Topics: Adolescent; Adult; Aged; Body Surface Area; Body Temperature; Body Temperature Regulation; Burns; Ca	1974
Fatal Streptococcus pyogenes septicemia associated with an intrauterine device. Obstetrics and gynecology, 1973, Volume: 41, Issue:1 Topics: Adult; Cervix Uteri; Chloramphenicol; Dexamethasone; Endometritis; Endometrium; Female; Humans; Intr	1973
Treatment of septicaemic shock in gynaecology and obstetrics. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1973, Oct-27, Volume: 47, Issue:42 Topics: Abortion, Septic; Adrenal Cortex Hormones; Bicarbonates; Blood Transfusion; Chloramphenicol; Digoxin	1973
Some aspects of the treatment of shock in animals. Journal of the South African Veterinary Association, 1972, Volume: 43, Issue:2 Topics: Adrenal Cortex Hormones; Animals; Blood Pressure; Blood Transfusion; Cardiac Output; Digitalis Glyco	1972
Hemodynamic studies and results of therapy in 50 patients with bacteremic shock. The American journal of medicine, 1973, Volume: 54, Issue:4 Topics: Adrenal Cortex Hormones; Adult; Aged; Dopamine; Enterobacteriaceae Infections; Female; Hemodynamics;	1973
Treatment of shock caused by bacterial infections. California medicine, 1973, Volume: 119, Issue:5 Topics: Anti-Bacterial Agents; Bacteria; Bacterial Infections; Bicarbonates; Glucocorticoids; Heparin; Human	1973
[Toxi-infectious shock]. Acta chirurgica Belgica, 1973, Volume: 72, Issue:3 Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Blood Transfusion; Chlorpromazine; Digitalis G	1973
Alkalosis in septic shock. Surgery, 1967, Volume: 62, Issue:4 Topics: Abscess; Acidosis; Adult; Alkalosis; Anuria; Blood Pressure Determination; Blood Volume Determinatio	1967
Gram-negative bacteremic shock: mechanisms and management. JAMA, 1969, Jan-13, Volume: 207, Issue:2 Topics: Adrenal Cortex Hormones; Escherichia coli Infections; Female; Gastrointestinal Diseases; Hemodynamic	1969
Hemodynamic alterations and results of treatment in patients with gram-negative septic shock. Surgery, 1970, Volume: 67, Issue:4 Topics: Adult; Aged; Ampicillin; Blood Pressure; Blood Transfusion; Cardiac Output; Central Venous Pressure;	1970
Septic shock. British medical journal, 1970, Jan-03, Volume: 1, Issue:5687 Topics: Animals; Dexamethasone; Dogs; Haplorhini; Humans; Hydrocortisone; Isoproterenol; Kanamycin; Mice; Ra	1970
Physiologic management of septicemic shock in man. Surgical forum, 1971, Volume: 22 Topics: Hemodynamics; Humans; Isoproterenol; Metaraminol; Middle Aged; Pulmonary Edema; Sepsis; Shock, Septi	1971
Gram-negative septicaemia--clinical aspects and physiological management. Proceedings of the Royal Society of Medicine, 1969, Dec-12, Volume: 62, Issue:12 Topics: Central Venous Pressure; Dexamethasone; Drainage; Hemorrhage; Humans; Infusions, Parenteral; Isoprot	1969
Hemodynamic evaluation of patients with puerperal sepsis and schock. American journal of obstetrics and gynecology, 1969, Nov-01, Volume: 105, Issue:5 Topics: Abortion, Septic; Adult; Blood Pressure; Cardiac Catheterization; Cardiac Output; Central Venous Pre	1969
Septic shock. Management of intra-abdominal abscesses. Minnesota medicine, 1970, Volume: 53, Issue:4 Topics: Abscess; Adrenal Cortex Hormones; Anti-Bacterial Agents; Blood Coagulation Disorders; Blood Transfus	1970
Shock and its management. Pediatric clinics of North America, 1969, Volume: 16, Issue:3 Topics: Anti-Bacterial Agents; Anticoagulants; Blood Cell Count; Blood Pressure; Blood Transfusion; Body Wei	1969

isoproterenol and Sepsis

Research Excerpts

Research

Studies (41)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Other Studies