isoproterenol and Sensitivity and Specificity studies

Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.

Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

Research Excerpts

Excerpt	Relevance	Reference
"Isoproterenol infusion alters consciousness level during total intravenous anesthesia for atrial fibrillation ablation."	9.16	Isoproterenol infusion increases level of consciousness during catheter ablation of atrial fibrillation. ( Aizer, A; Bloom, M; Chinitz, L; Linton, P; O'Neill, DK; Rose, E, 2012)
"To determine the sensitivity and specificity of isoproterenol for the induction of atrial fibrillation (AF)."	9.13	Inducibility of paroxysmal atrial fibrillation by isoproterenol and its relation to the mode of onset of atrial fibrillation. ( Bogun, F; Chalfoun, N; Chugh, A; Crawford, T; Dey, S; Frederick, M; Gadeela, N; Good, E; Jongnarangsin, K; Kuhne, M; Morady, F; Oral, H; Pelosi, F; Sarrazin, JF; Wells, D; Wimmer, A, 2008)
"To investigate the value of head-up tilt table testing (HUTT) with low-dose isosorbide dinitrate (ISDN) in the evaluation of patients with unexplained syncope and to compare the results of HUTT with ISDN and HUTT with isoproterenol."	9.10	Head-up tilt table testing with low dose sublingual isosorbide dinitrate in the evaluation of unexplained syncope: a comparison with isoproterenol infusion. ( Akdeniz, B; Aslan, O; Badak, O; Goldeli, O; Guneri, S; Keskin, V; Kirimli, O; Tekin, U, 2002)
"Comparison of upright tilt testing with isoproterenol in patients with syncope of unknown etiology and in controls."	9.07	Evaluation of syncope by upright tilt testing with isoproterenol. A nonspecific test. ( Brant, N; Kapoor, WN, 1992)
"The purpose of the study was to evaluate the interests of electrophysiologic study (EPS) after infusion of isoproterenol in patients with syncope and negative EPS in control state."	7.73	Increased sensitivity of electrophysiological study by isoproterenol infusion in unexplained syncope. ( Andronache, M; Belhakem, H; Beurrier, D; Brembilla-Perrot, B; Claudon, O; Houriez, P; Louis, P; Marçon, O; Muhanna, I; Nippert, M; Popovic, B; Terrier de la Chaise, A, 2006)
"The aim of our present study was to assess the value of nitroglycerin infusion during upright posture as a new provocative test for diagnosis of vasovagal syncope."	7.69	Nitroglycerin infusion during upright tilt: a new test for the diagnosis of vasovagal syncope. ( Alboni, P; Brignole, M; Di Pede, F; Dinelli, M; Gasparini, G; Menozzi, C; Piccolo, E; Raviele, A, 1994)
"Head-up tilt testing with or without isoproterenol is extensively used in the evaluation of patients with unexplained syncope."	7.69	Comparison of sensitivity and specificity of tilt protocols with and without isoproterenol in children with unexplained syncope. ( Alehan, D; Celiker, A; Lenk, M; Ozer, S; Ozme, S, 1997)
"Thirty-six patients with unexplained recurrent syncope/presyncope (7 to 35 years old, known heart disease or arrhythmia in 14) underwent 2 to 4 HUT tests (60 degrees, 49 minutes): (1) baseline, (2) esmolol (500 micrograms/kg plus 50 micrograms."	7.69	Esmolol tilt testing with esmolol withdrawal for the evaluation of syncope in the young. ( Ovadia, M; Thoele, D, 1994)
"Propofol has a direct and negative effect on basal myocyte contractile processes in the setting of CHF, which is more pronounced than that on healthy myocytes at reduced propofol concentrations."	5.30	Negative and selective effects of propofol on isolated swine myocyte contractile function in pacing-induced congestive heart failure. ( Clair, MJ; Dorman, BH; Hebbar, L; Roy, RC; Spinale, FG, 1997)
" Subjects underwent either passive HUT (45 min, 60 degrees without drug dosing for 48 subjects in group S (S1) and 17 in group V (V1), or HUT with isoproterenol infusion at progressive doses (2 then 5 micrograms/min) after 30 minutes of passive tilting for 28 patients in group S (S2) and 18 in group V (V2)."	5.30	Prospective evaluation of high-dose or low-dose isoproterenol upright tilt protocol for unexplained syncope in young adults. ( Bodart, JC; Burlaton, JP; Carlioz, R; Graux, P; Guyomar, Y; Haye, J; Hubert, E; Lequeuche, B; Letourneau, T, 1997)
"To evaluate the incidence and clinical outcome of adenosine triphosphate (ATP) plus isoproterenol (ISP)-induced non-pulmonary vein (PV) foci before and after circumferential PV isolation (CPVI) during index ablation in patients with paroxysmal atrial fibrillation (PAF)."	5.19	Non-pulmonary vein foci induced before and after pulmonary vein isolation in patients undergoing ablation therapy for paroxysmal atrial fibrillation: incidence and clinical outcome. ( Chen, SQ; Cheng, H; Dai, YY; Jiang, CY; Jiang, RH; Lin, JW; Liu, Q; Sheng, X; Sun, YX; Zhang, ZW; Zhu, J, 2014)
"Isoproterenol infusion alters consciousness level during total intravenous anesthesia for atrial fibrillation ablation."	5.16	Isoproterenol infusion increases level of consciousness during catheter ablation of atrial fibrillation. ( Aizer, A; Bloom, M; Chinitz, L; Linton, P; O'Neill, DK; Rose, E, 2012)
"To determine the sensitivity and specificity of isoproterenol for the induction of atrial fibrillation (AF)."	5.13	Inducibility of paroxysmal atrial fibrillation by isoproterenol and its relation to the mode of onset of atrial fibrillation. ( Bogun, F; Chalfoun, N; Chugh, A; Crawford, T; Dey, S; Frederick, M; Gadeela, N; Good, E; Jongnarangsin, K; Kuhne, M; Morady, F; Oral, H; Pelosi, F; Sarrazin, JF; Wells, D; Wimmer, A, 2008)
"To investigate the value of head-up tilt table testing (HUTT) with low-dose isosorbide dinitrate (ISDN) in the evaluation of patients with unexplained syncope and to compare the results of HUTT with ISDN and HUTT with isoproterenol."	5.10	Head-up tilt table testing with low dose sublingual isosorbide dinitrate in the evaluation of unexplained syncope: a comparison with isoproterenol infusion. ( Akdeniz, B; Aslan, O; Badak, O; Goldeli, O; Guneri, S; Keskin, V; Kirimli, O; Tekin, U, 2002)
"Epinephrine or isoproterenol is a reliable marker to detect accidental intravascular injection of a test dose with 100% sensitivity and specificity based on a new heart rate criterion in sevoflurane-anesthetized children."	5.09	Oral clonidine premedication does not change efficacy of simulated epidural test dose in sevoflurane-anesthetized children. ( Maekawa, N; Mikawa, K; Nishina, K; Obara, H; Shiga, M; Uesugi, T, 2000)
"In this study the tilt test, in combination with isoproterenol administration, was used to investigate 44 patients with unexplained syncope."	5.08	The contribution of isoproterenol to the prolonged tilt test. ( Chrysostomakis, SI; Kochiadakis, GE; Orfanakis, AE; Simandirakis, EN; Skalidis, EI; Vardas, PE, 1995)
"During isoflurane anesthesia, an epinephrine-containing test dose produces unreliable heart rate (HR) responses with a high incidence of hypertension, whereas an isoproterenol-containing test dose results in a high incidence of hypotension."	5.08	The combination of epinephrine and isoproterenol as a simulated epidural test dose in isoflurane-anesthetized adults. ( Nishikawa, T; Tanaka, M, 1998)
"The nonspecific phosphodiesterase inhibitor theophylline, widely used in asthma therapy, may cause a decrease in inflammatory responses of airways."	5.08	Effect of theophylline on CD11b and L-selectin expression and density of eosinophils and neutrophils in vitro. ( Berends, C; de Monchy, JG; Dijkhuizen, B; Kauffman, HF; Spoelstra, FM, 1998)
"Comparison of upright tilt testing with isoproterenol in patients with syncope of unknown etiology and in controls."	5.07	Evaluation of syncope by upright tilt testing with isoproterenol. A nonspecific test. ( Brant, N; Kapoor, WN, 1992)
" Consistently, TβRIII expression was substantially increased in transverse aortic constriction (TAC)- and isoproterenol-induced mouse cardiac hypertrophy in vivo and in isoproterenol-induced cardiomyocyte hypertrophy in vitro."	3.83	Type III Transforming Growth Factor-β Receptor Drives Cardiac Hypertrophy Through β-Arrestin2-Dependent Activation of Calmodulin-Dependent Protein Kinase II. ( Chu, W; Ding, XQ; Dong, CJ; Ji, Y; Li, H; Li, YC; Li, YY; Liu, MT; Lou, J; Song, SY; Sun, F; Yu, CJ; Zhang, LL; Zhang, ZR; Zhao, D, 2016)
"The purpose of the study was to evaluate the interests of electrophysiologic study (EPS) after infusion of isoproterenol in patients with syncope and negative EPS in control state."	3.73	Increased sensitivity of electrophysiological study by isoproterenol infusion in unexplained syncope. ( Andronache, M; Belhakem, H; Beurrier, D; Brembilla-Perrot, B; Claudon, O; Houriez, P; Louis, P; Marçon, O; Muhanna, I; Nippert, M; Popovic, B; Terrier de la Chaise, A, 2006)
"The purpose of this study were to determine the specificity of the head-up tilt test in normal subjects when a graded isoproterenol infusion is used, and to evaluate the role of dynamic ventricular volume change during head-up tilt as a mechanism of syncope."	3.69	Hemodynamic and volumetric response of the normal left ventricle to upright tilt testing. ( Grogan, EW; Hanson, P; Nwosu, EA; Rahko, PS, 1994)
"Thirty-six patients with unexplained recurrent syncope/presyncope (7 to 35 years old, known heart disease or arrhythmia in 14) underwent 2 to 4 HUT tests (60 degrees, 49 minutes): (1) baseline, (2) esmolol (500 micrograms/kg plus 50 micrograms."	3.69	Esmolol tilt testing with esmolol withdrawal for the evaluation of syncope in the young. ( Ovadia, M; Thoele, D, 1994)
"The rate of positive head-up tilt (HUT), specificity, and same-day reproducibility of an HUT at 60 degrees combined with a low-dose isoproterenol infusion was assessed in the following patients: 120 consecutive patients with recurrent unexplained syncope, 30 healthy patients in a control group, and 30 patients with documented syncope not related to a vasodepressor reaction."	3.69	Diagnostic accuracy of a low-dose isoproterenol head-up tilt protocol. ( Klein, GJ; Morillo, CA; Yee, R; Zandri, S, 1995)
"Head-up tilt testing with or without isoproterenol is extensively used in the evaluation of patients with unexplained syncope."	3.69	Comparison of sensitivity and specificity of tilt protocols with and without isoproterenol in children with unexplained syncope. ( Alehan, D; Celiker, A; Lenk, M; Ozer, S; Ozme, S, 1997)
"The aim of our present study was to assess the value of nitroglycerin infusion during upright posture as a new provocative test for diagnosis of vasovagal syncope."	3.69	Nitroglycerin infusion during upright tilt: a new test for the diagnosis of vasovagal syncope. ( Alboni, P; Brignole, M; Di Pede, F; Dinelli, M; Gasparini, G; Menozzi, C; Piccolo, E; Raviele, A, 1994)
" We wondered if prolonged infusion of isoproterenol or PGE1 would cause desensitization of smooth muscle relaxation and used the dorsal hand-vein compliance technique to investigate this question."	3.68	Desensitization of beta-adrenoceptor- and prostaglandin E1 receptor-mediated human vascular smooth muscle relaxation. ( Blaschke, TF; Hoffman, BB; Vincent, J, 1992)
"Of them, 56 had a diagnostic history of neurocardiogenic syncope, whereas 29 served as controls."	2.73	Provocation of neurocardiogenic syncope during head-up tilt testing in children: comparison between isoproterenol and nitroglycerin. ( Barka, T; Katsouras, CS; Kolettis, TM; Michalis, LK; Siamopoulou, A; Sionti, I; Tzoufi, M; Vlahos, AP, 2007)
"The treatments (isoproterenol and saline solution) were administered in a period-balanced two-way crossover design with randomly allocated sequences."	2.67	Relative sensitivity of four noninvasive methods in assessing systolic cardiovascular effects of isoproterenol in healthy volunteers. ( Belz, GG; Butzer, R; de Mey, C; Erbel, R; Meyer, J; Nixdorf, U; Schroeter, V, 1992)
"It can also help differentiate convulsive syncope from epilepsy."	2.38	Head-upright tilt test: a new method of evaluating syncope. ( Grubb, BP; Kimmel, SR; Wolfe, DA, 1993)
"Post-isoproterenol treatment cardiac troponin I concentrations were greater in CD/IGS and Sasco rats compared with Harlan rats."	1.37	A comparison of mortality and cardiac biomarker response between three outbred stocks of Sprague Dawley rats treated with isoproterenol. ( Ackermann, BL; Hall, DG; Hoffman, WP; Lee, HY; Main, BW; Pritt, ML; Schultze, AE; Smith, HW, 2011)
"Sublingual ISDN is less sensitive and less safe compared to intravenous ISOP in assessing pediatric age patients with suspected neurocardiogenic syncope and with a negative result in tilt test without provocation."	1.35	Head-up tilt table testing in syncope: safety and efficiency of isosorbide versus isoproterenol in pediatric population. ( Caspi, A; Epstein, M; Paz, O; Shimoni, S; Swissa, M, 2008)
" Subjects underwent either passive HUT (45 min, 60 degrees without drug dosing for 48 subjects in group S (S1) and 17 in group V (V1), or HUT with isoproterenol infusion at progressive doses (2 then 5 micrograms/min) after 30 minutes of passive tilting for 28 patients in group S (S2) and 18 in group V (V2)."	1.30	Prospective evaluation of high-dose or low-dose isoproterenol upright tilt protocol for unexplained syncope in young adults. ( Bodart, JC; Burlaton, JP; Carlioz, R; Graux, P; Guyomar, Y; Haye, J; Hubert, E; Lequeuche, B; Letourneau, T, 1997)
"Propofol has a direct and negative effect on basal myocyte contractile processes in the setting of CHF, which is more pronounced than that on healthy myocytes at reduced propofol concentrations."	1.30	Negative and selective effects of propofol on isolated swine myocyte contractile function in pacing-induced congestive heart failure. ( Clair, MJ; Dorman, BH; Hebbar, L; Roy, RC; Spinale, FG, 1997)
"Ozone is a ubiquitous air pollutant which can affect numerous function s of the respiratory system."	1.29	Ozone-induced alteration in beta-adrenergic pharmacological modulation of pulmonary macrophages. ( Chen, LC; el-Fawal, HA; McGovern, TJ; Schlesinger, RB, 1996)
"6 MAC halothane did not significantly affect the dose-response relationship between isoproterenol and force."	1.29	Halothane and pertussis toxin-sensitive G proteins in airway smooth muscle. ( Jones, KA; Morimoto, N; Warner, DO; Yamamoto, K, 1994)
"The diagnosis of ventricular tachycardia could therefore be continued."	1.29	[Should protocol of programmed ventricular stimulation be adapted to each patient? ]. ( Brembilla-Perrot, B; Houplon, P; Jacquemin, L; Lemoine, C; Mathieu, P, 1996)
"Isoproterenol was infused as a dose titrated to increase the sinus rate by 25% or to a rate of 100 beats/min, whichever was greater, and stimulation then was repeated with single and double extrastimuli."	1.28	A prospective comparison of programmed ventricular stimulation with triple extrastimuli versus single and double extrastimuli during infusion of isoproterenol. ( Baerman, JM; de Buitleir, M; DiCarlo, LA; Kou, WH; Morady, F; Nelson, SD, 1989)

Research

Studies (120)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

BIS Change

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (3.33)	18.7374
1990's	58 (48.33)	18.2507
2000's	42 (35.00)	29.6817
2010's	16 (13.33)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Yao, X	1
Parnot, C	1
Deupi, X	1
Ratnala, VR	1
Swaminath, G	1
Farrens, D	1
Kobilka, B	1
Khemtong, C	1
Carpenter, NR	1
Lumata, LL	1
Merritt, ME	1
Moreno, KX	1
Kovacs, Z	1
Malloy, CR	1
Sherry, AD	1
Cheng, H	1
Dai, YY	1
Jiang, RH	1
Liu, Q	1
Sun, YX	1
Lin, JW	1
Zhang, ZW	1
Chen, SQ	1
Zhu, J	1
Sheng, X	1
Jiang, CY	1
Jiménez-Cohl, P	1
Vega, S	1
Cáceres, R	1
Gómez, C	1
Rojas, N	1
Tridello, G	1
Menin, L	1
Pintani, E	1
Bergamini, G	1
Assael, BM	1
Melotti, P	1
Lou, J	1
Zhao, D	1
Zhang, LL	1
Song, SY	1
Li, YC	1
Sun, F	1
Ding, XQ	1
Yu, CJ	1
Li, YY	1
Liu, MT	1
Dong, CJ	1
Ji, Y	1
Li, H	1
Chu, W	1
Zhang, ZR	1
Michel, FS	1
Magubane, M	1
Mokotedi, L	1
Norton, GR	1
Woodiwiss, AJ	1
Monassier, L	1
Laplante, MA	1
Jaffré, F	1
Bousquet, P	1
Maroteaux, L	1
de Champlain, J	1
Liu, YM	2
Cao, JT	2
Zheng, YL	2
Chen, YH	1
Schultze, AE	2
Konrad, RJ	1
Credille, KM	1
Lu, QA	1
Todd, J	1
Vavetsi, S	1
Nikolaou, N	1
Tsarouhas, K	1
Lymperopoulos, G	1
Kouzanidis, I	1
Kafantaris, I	1
Antonakopoulos, A	1
Tsitsimpikou, C	1
Kandylas, J	1
Swissa, M	1
Epstein, M	1
Paz, O	1
Shimoni, S	1
Caspi, A	1
Jackson, EK	1
Mi, Z	1
Crawford, T	2
Chugh, A	2
Good, E	2
Yoshida, K	1
Jongnarangsin, K	2
Ebinger, M	1
Pelosi, F	2
Bogun, F	2
Morady, F	3
Oral, H	2
Wong, J	1
Chang, C	1
Agrawal, R	1
Walton, GB	1
Chen, C	1
Murthy, A	1
Patterson, AJ	1
Clements, P	1
Brady, S	1
York, M	1
Berridge, B	1
Mikaelian, I	1
Nicklaus, R	1
Gandhi, M	1
Roman, I	1
Stamp, C	1
Davies, D	1
McGill, P	1
Williams, T	1
Pettit, S	1
Walker, D	1
Turton, J	1
Lai, WT	1
Chen, MR	1
Lin, SM	1
Hwang, HK	1
Sicouri, S	1
Gianetti, B	1
Zygmunt, AC	1
Cordeiro, JM	1
Antzelevitch, C	1
Main, BW	1
Hall, DG	1
Hoffman, WP	1
Lee, HY	1
Ackermann, BL	1
Pritt, ML	1
Smith, HW	1
O'Neill, DK	1
Aizer, A	1
Linton, P	1
Bloom, M	1
Rose, E	1
Chinitz, L	1
Täng, MS	1
Redfors, B	1
Shao, Y	1
Omerovic, E	1
Macedo, PG	1
Asirvatham, SJ	1
Maia, L	1
Ferreira Neto, E	1
Zanatta, A	1
Sobral Neto, J	1
Barreto, JR	1
Maia, H	1
Oliveira, EM	1
Da Rocha, JM	1
Margalho, CS	1
Seixas, T	1
Peres, A	1
Santos-Neto, L	1
Leite, LR	1
Barold, SS	1
Stroobandt, RX	1
Aslan, O	1
Guneri, S	1
Badak, O	1
Kirimli, O	1
Goldeli, O	1
Keskin, V	1
Akdeniz, B	1
Tekin, U	1
Hesley, J	1
Daijo, J	1
Ferguson, AT	1
Busch, L	1
Borda, E	1
Yakabe, T	1
Yoshida, H	1
Nohta, H	1
Yamaguchi, M	1
Arora, R	1
Verheule, S	1
Scott, L	1
Navarrete, A	1
Katari, V	1
Wilson, E	1
Vaz, D	1
Olgin, JE	1
Leor-Librach, RJ	1
Eliash, S	1
Kaplinsky, E	1
Bobrovsky, BZ	1
Male, KB	1
Luong, JH	1
Sumiyoshi, M	2
Abe, H	1
Mineda, Y	2
Tokano, T	1
Yasuda, M	1
Nakazato, K	1
Nakazato, Y	2
Nakata, Y	2
Daida, H	1
Allen-Gipson, DS	1
Romberger, DJ	1
Forget, MA	1
May, KL	1
Sisson, JH	1
Wyatt, TA	1
Wright, CI	1
Sheldon, RS	1
Tyberg, JV	1
Davies, MG	1
Geddes, DM	1
Alton, EW	1
Aerts, AJ	1
Dendale, P	1
Block, P	1
Dassen, WR	1
Brembilla-Perrot, B	3
Muhanna, I	1
Marçon, O	1
Popovic, B	1
Terrier de la Chaise, A	1
Louis, P	1
Andronache, M	1
Nippert, M	1
Claudon, O	1
Beurrier, D	1
Houriez, P	1
Belhakem, H	1
Haasen, D	1
Wolff, M	1
Valler, MJ	1
Heilker, R	1
Salamé, E	1
Neemtallah, R	1
Azar, R	1
Antonios, S	1
Jazra, C	1
Kassab, R	1
Karthikeyan, K	1
Bai, BR	1
Devaraj, SN	1
Sermet-Gaudelus, I	1
Roussel, D	1
Bui, S	1
Deneuville, E	1
Huet, F	1
Reix, P	1
Bellon, G	1
Lenoir, G	1
Edelman, A	1
Vlahos, AP	1
Tzoufi, M	1
Katsouras, CS	1
Barka, T	1
Sionti, I	1
Michalis, LK	1
Siamopoulou, A	1
Kolettis, TM	1
Cunliffe, JM	1
Whorton, MR	1
Sunahara, RK	1
Kennedy, RT	1
Wang, CQ	1
Mu, HB	1
Soyer, T	1
Keskil, ZA	1
Somuncu, S	1
Aydos, TR	1
Korkut, O	1
Kanmaz, T	1
Cakmak, M	1
Frederick, M	1
Gadeela, N	1
Wimmer, A	1
Dey, S	1
Sarrazin, JF	1
Kuhne, M	1
Chalfoun, N	1
Wells, D	1
Jacobson, J	1
Passman, R	1
Hou, ZY	1
Yang, CY	1
Ko, CC	1
Lee, SS	1
Chiang, HT	1
Chen, CY	1
Gether, U	1
Lin, S	1
Kobilka, BK	1
Mittleman, RS	1
Candinas, R	1
Collett-Willey, P	1
Huang, SK	1
Willemsen, JJ	1
Ross, HA	1
Jacobs, MC	1
Lenders, JW	1
Thien, T	1
Swinkels, LM	1
Benraad, TJ	1
Morillo, CA	1
Klein, GJ	1
Zandri, S	1
Yee, R	1
Kondoh, Y	1
Sugawara, M	1
Uchida, K	1
Allgaier, C	1
Schobert, A	1
Belledin, M	1
Jackisch, R	1
Hertting, G	1
Schilt, R	1
Hooijerink, H	1
Huf, FA	1
Zuiderveld, OP	1
Bast, A	1
Carr, RE	1
Humphreys, SM	1
Frayn, KN	1
Moura, MJ	1
De Moraes, S	1
Ovadia, M	1
Thoele, D	1
Nwosu, EA	1
Rahko, PS	1
Hanson, P	1
Grogan, EW	1
Lippman, N	1
Stein, KM	2
Lerman, BB	2
Jalil, J	1
Radrigán, FJ	1
González, R	1
Godoy, I	1
Fajuri, A	1
Chamorro, G	1
Casanegra, P	1
Valenzuela, C	1
Elnatan, A	1
Mitchelson, F	1
Raviele, A	1
Gasparini, G	1
Di Pede, F	1
Menozzi, C	1
Brignole, M	1
Dinelli, M	1
Alboni, P	1
Piccolo, E	1
Morimoto, N	1
Yamamoto, K	1
Jones, KA	1
Warner, DO	1
Hansel, TT	1
Schwarz, F	1
Villiger, B	1
Naef, R	1
Richardson, BP	1
Morley, J	1
Wolfe, DA	1
Grubb, BP	2
Kimmel, SR	1
Jones, LG	1
McGovern, TJ	1
el-Fawal, HA	1
Chen, LC	1
Schlesinger, RB	1
Tanaka, M	2
Trovik, TS	1
Vaartun, A	1
Jorde, R	1
Sager, G	1
Chou, RC	1
Stinson, MW	1
Noble, BK	1
Spengler, RN	1
Lippert, FK	2
Yndgaard, S	2
Berthelsen, PG	2
Kochiadakis, GE	1
Orfanakis, AE	1
Chrysostomakis, SI	1
Skalidis, EI	1
Simandirakis, EN	1
Vardas, PE	1
Sheldon, R	1
Rose, S	1
Koshman, ML	1
Watts, VJ	1
Neve, KA	1
Hasenfuss, G	1
Pieske, B	1
Kretschmann, B	1
Holubarsch, C	1
Alpert, NR	1
Just, H	1
Raybaud, F	1
Camous, JP	1
Jung, M	1
Dadoun, M	1
Baudouy, M	1
Morand, P	1
Carlioz, R	1
Graux, P	1
Haye, J	1
Letourneau, T	1
Guyomar, Y	1
Hubert, E	1
Bodart, JC	1
Lequeuche, B	1
Burlaton, JP	1
Hebbar, L	1
Dorman, BH	1
Clair, MJ	1
Roy, RC	1
Spinale, FG	1
Houplon, P	1
Jacquemin, L	1
Lemoine, C	1
Mathieu, P	1
Noh, CI	1
Kim, HS	1
Hauger, RL	1
Dautzenberg, FM	1
Flaccus, A	1
Liepold, T	1
Spiess, J	1
Alehan, D	1
Lenk, M	1
Ozme, S	1
Celiker, A	1
Ozer, S	1
Kosinski, D	1
Temesy-Armos, P	1
Brewster, P	1
Billman, GE	1
Castillo, LC	1
Hensley, J	1
Hohl, CM	1
Altschuld, RA	1
Van de Walle, JP	1
Panagides, D	1
Messier, M	1
Iovescu, D	1
Fourcade, L	1
Bory, M	1
Touze, JE	1
Nishikawa, T	1
Spoelstra, FM	1
Berends, C	1
Dijkhuizen, B	1
de Monchy, JG	1
Kauffman, HF	1
Tittelbach, V	1
Volff, JN	1
Giray, J	1
Ratge, D	1
Wisser, H	1
Natale, A	1
Sra, J	1
Akhtar, M	1
Kusmirek, L	1
Tomassoni, G	1
Leonelli, F	1
Newby, K	1
Beheiry, S	1
Pacifico, A	1
Kapoor, WN	2
Mittal, S	1
Markowitz, SM	1
Slotwiner, DJ	1
Rohatgi, S	1
Shen, WK	1
Jahangir, A	1
Beinborn, D	1
Lohse, CM	1
Hodge, DO	1
Rea, RF	1
Hammill, SC	1
Zeng, C	1
Zhu, Z	1
Hu, W	1
Liu, G	1
Zhu, S	1
Zhou, Y	1
Shi, W	1
Moore, RH	1
Hall, HS	1
Rosenfeld, JL	1
Dai, W	1
Knoll, BJ	1
Kevelaitis, E	1
Nyborg, NC	1
Menasché, P	1
Oraii, S	1
Maleki, M	1

Trial	Enrollment	Study Type	Start Date	Status
Study to Measure BIS and Awareness in Patients Receiving Isoproterenol During Catheter Ablation for Atrial Fibrillation[NCT01377636]	20 participants (Actual)	Interventional	2009-08-31	Completed
Multi-center, Randomized, Controlled Trial to Compare Feasibility, Safety and Efficacy of Zero-Fluoroscopic Navigation With Conventional Fluoroscopic Navigation for the Ablation of Right Atrial Arrhythmias[NCT03151278]	212 participants (Actual)	Interventional	2011-01-31	Completed
[NCT00005202]	0 participants	Observational	1987-07-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The BIS scale ranges from 0 to 100. The individual's baseline BIS was measured continuously and was maintained in an anesthetic steady state with minimum variance prior to isoproterenol. A deviation from the mean in excess of 3 points (2 STD) was defined categorically as a positive response and was counted dichotomously.The difference between Pre-BIS and Post-BIS was calculated. (NCT01377636)
Timeframe: Within 20 minutes of starting isoproterenol infusion

Number of Participants Who Developed Ischemia or ST Segment Changes

Intervention	units on a scale (Mean)
Pre and Post Isoproterenol Infusion	24.6

The (ST) segment on the EKG was monitored for changes suggestive of demand ischemia. An observable EKG change compared to baseline was defined categorically as a positive response and was counted dichotomously. (NCT01377636)
Timeframe: Within 20 minutes of starting isoproterenol infusion

Number of Participants Who Follow Verbal Command to Squeeze Hands

Intervention	participants (Number)
Pre and Post Isoproterenol Infusion	2

"Increasing doses of isoproterenol (5,10,15,20 mcg/minute) were administered to patients undergoing catheter ablation for atrial fibrillation. Ability to follow verbal commands before and after isoproterenol infusion was assessed by asking subjects to squeeze my hands." (NCT01377636)
Timeframe: Within 20 minutes of starting isoproterenol infusion

Number of Participants With Amnesia or No Recall During Steady State

Intervention	participants (Number)
Isoproterenol, BIS, Forearm Test	10

Increasing doses of isoproterenol (5,10,15,20 mcg/minute) were administered to patients undergoing catheter ablation for atrial fibrillation. Specific pre-determined test words were spoken to the subject during administration of isoproterenol. After anesthesia, patients were tested for possible recall of those specific words. If no words were recalled, the result was categorically defined as amnesia. (NCT01377636)
Timeframe: Within one hour of completing anesthesia

Number of Participants With an Increase in BIS Readings During Steady State

Intervention	participants (Number)
Isoproterenol, BIS, Forearm Test	20

Increasing doses of isoproterenol (5,10,15,20 mcg/minute) were administered to patients undergoing catheter ablation for atrial fibrillation. BIS levels were measured continuously before and after isoproterenol administration. Number of participants with increase in BIS reading during anesthetic steady state are reported below. The BIS scale ranges from 0 to 100. The individual's baseline BIS was measured continuously and was maintained in an anesthetic steady state with minimum variance prior to isoproterenol. A deviation from the mean in excess of 3 points (2 STD) was defined categorically as a positive response and was counted dichotomously. (NCT01377636)
Timeframe: During time of Electrophysiology (EP) studies.

Number of Participants With Change in Blood Pressure

Intervention	participants (Number)
Pre and Post Isoproterenol Infusion	19

Non-Invasive Blood Pressure (NIBP) is measured routinely as part of an anesthetic. Pre- and Post Blood Pressures where noted. An increase or decrease of 10 percent or more was defined as a significant change in systolic blood pressure. (NCT01377636)
Timeframe: Within 20 minutes of starting isoproterenol infusion

Number of Participants With New Arrhythmia During Steady State.

Intervention	participants (Number)
Pre and Post Isoproterenol Infusion	13

Increasing doses of isoproterenol (5,10,15,20 mcg/minute) were administered to patients undergoing catheter ablation for atrial fibrillation after return to sinus rhythm. If a non-sinus arrhythmia resulted from the infusion, the arrhythmia was defined categorically as a positive response and was counted dichotomously. (NCT01377636)
Timeframe: Within 20 minutes of start of isoproterenol

Number of Participants With Significant Change in Heart Rate

Intervention	participants (Number)
Pre and Post Isoproterenol Infusion	4

Heart rate measured by standard EKG monitor during anesthesia. Pre- and Post Heart rates where noted. An increase of 8 percent or more was defined as a significant change in heart rate. (NCT01377636)
Timeframe: Within 20 minutes of starting isoproterenol infusion

Number of Participants With Spontaneous Musculoskeletal Movement

Intervention	participants (Number)
Pre and Post Isoproterenol Infusion	18

Increasing doses of isoproterenol (5,10,15,20 mcg/minute) were administered to patients undergoing catheter ablation for atrial fibrillation. Patients under steady state total venous anesthesia (TIVA) with propofol and remifentanil infusions with BIS around 50 normally do not move even in the absence of neuromuscular blockade. Spontaneous movement appearing like restlessness during sleep is unusual. Several patients under anesthesia after isoproterenol appear to wake up and move spontaneously. (NCT01377636)
Timeframe: Within 20 minutes of starting isoproterenol infusion

Article	Year
Head-upright tilt test: a new method of evaluating syncope. American family physician, 1993, Volume: 47, Issue:1 Topics: Adolescent; Age Factors; Clinical Protocols; Decision Trees; Electroencephalography; Family Practice	1993
[Comparative data of tilt test with or without isoproterenol in investigation of unexplained unconsciousness and syncope]. Archives des maladies du coeur et des vaisseaux, 1996, Volume: 89, Issue:9 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Blood Pressure; Female; Heart Rate; Humans;	1996
Using a tilt table to evaluate syncope. The American journal of the medical sciences, 1999, Volume: 317, Issue:2 Topics: Adrenergic beta-Agonists; Autonomic Nervous System; Diagnosis, Differential; Humans; Isoproterenol;	1999
[Head-up tilt test]. Journal of cardiology, 2000, Volume: 35 Suppl 1 Topics: Adult; Humans; Isoproterenol; Sensitivity and Specificity; Sympathomimetics; Syncope; Tilt-Table Tes	2000
Tilt methodology in reflex syncope: emerging evidence. Journal of the American College of Cardiology, 2000, Volume: 36, Issue:1 Topics: Central Nervous System; Cholinesterase Inhibitors; Clomipramine; Diagnosis, Differential; Edrophoniu	2000

Article	Year
Non-pulmonary vein foci induced before and after pulmonary vein isolation in patients undergoing ablation therapy for paroxysmal atrial fibrillation: incidence and clinical outcome. Journal of Zhejiang University. Science. B, 2014, Volume: 15, Issue:10 Topics: Adenosine Triphosphate; Atrial Fibrillation; Cardiotonic Agents; Catheter Ablation; Female; Heart Co	2014
Consecutive administration of atropine and isoproterenol for the evaluation of asymptomatic sinus bradycardia. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2008, Volume: 10, Issue:10 Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Atropine; Bradycardia; Electrocardiography; Female; Human	2008
Clinical value of noninducibility by high-dose isoproterenol versus rapid atrial pacing after catheter ablation of paroxysmal atrial fibrillation. Journal of cardiovascular electrophysiology, 2010, Volume: 21, Issue:1 Topics: Atrial Fibrillation; Cardiac Pacing, Artificial; Cardiotonic Agents; Catheter Ablation; Dose-Respons	2010
Application of head-up tilt table testing in children. Journal of the Formosan Medical Association = Taiwan yi zhi, 2010, Volume: 109, Issue:9 Topics: Adolescent; Child; Cohort Studies; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Isopro	2010
Isoproterenol infusion increases level of consciousness during catheter ablation of atrial fibrillation. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2012, Volume: 34, Issue:2 Topics: Adult; Aged; Anesthetics, Intravenous; Atrial Fibrillation; Catheter Ablation; Consciousness; Electr	2012
Comparison of a shortened isosorbide dinitrate-potentiated head-up tilt testing with the conventional protocol: tolerance and diagnostic accuracy. Pacing and clinical electrophysiology : PACE, 2012, Volume: 35, Issue:8 Topics: Adult; Diagnostic Errors; Female; Humans; Isoproterenol; Isosorbide Dinitrate; Male; Nitroglycerin;	2012
Head-up tilt table testing with low dose sublingual isosorbide dinitrate in the evaluation of unexplained syncope: a comparison with isoproterenol infusion. The Canadian journal of cardiology, 2002, Volume: 18, Issue:8 Topics: Administration, Sublingual; Adult; Cardiovascular Agents; Female; Humans; Infusions, Intravenous; Is	2002
[Sensitization of tilt-table testing for syncope of unknown etiology: which drug to use?]. Annales de cardiologie et d'angeiologie, 2006, Volume: 55, Issue:3 Topics: Administration, Sublingual; Adolescent; Adult; Aged; Blood Pressure; Cardiotonic Agents; Cardiovascu	2006
Provocation of neurocardiogenic syncope during head-up tilt testing in children: comparison between isoproterenol and nitroglycerin. Pediatrics, 2007, Volume: 119, Issue:2 Topics: Administration, Sublingual; Child; Female; Humans; Injections, Intravenous; Isoproterenol; Male; Nit	2007
Inducibility of paroxysmal atrial fibrillation by isoproterenol and its relation to the mode of onset of atrial fibrillation. Journal of cardiovascular electrophysiology, 2008, Volume: 19, Issue:5 Topics: Adrenergic beta-Agonists; Adult; Atrial Fibrillation; Dose-Response Relationship, Drug; Electrocardi	2008
Differential therapeutic responses of patients with isoproterenol-dependent and isoproterenol-independent vasodepressor syncope. American heart journal, 1994, Volume: 128, Issue:6 Pt 1 Topics: Adrenergic beta-Antagonists; Aged; Female; Hemodynamics; Humans; Isoproterenol; Male; Middle Aged; S	1994
Anomalous bronchospasm following inhalation of (+) isoprenaline by asthmatics. Agents and actions. Supplements, 1993, Volume: 43 Topics: Administration, Inhalation; Asthma; Bronchial Spasm; Double-Blind Method; Humans; Isoproterenol; Sen	1993
Epidural test dose: isoproterenol is a reliable marker for intravascular injection in anesthetized adults. Anesthesia and analgesia, 1996, Volume: 82, Issue:5 Topics: Adult; Anesthesia, Epidural; Anesthetics, Inhalation; Biomarkers; Blood Pressure; Female; Heart Rate	1996
The contribution of isoproterenol to the prolonged tilt test. International journal of cardiology, 1995, Nov-24, Volume: 52, Issue:2 Topics: Blood Pressure; Cardiotonic Agents; Female; Heart Rate; Humans; Infusions, Intravenous; Isoprotereno	1995
The combination of epinephrine and isoproterenol as a simulated epidural test dose in isoflurane-anesthetized adults. Anesthesia and analgesia, 1998, Volume: 86, Issue:6 Topics: Adrenergic Agonists; Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; Blood V	1998
Effect of theophylline on CD11b and L-selectin expression and density of eosinophils and neutrophils in vitro. The European respiratory journal, 1998, Volume: 12, Issue:3 Topics: Adolescent; Adrenergic beta-Agonists; Adult; Asthma; Blood Cell Count; Cells, Cultured; Down-Regulat	1998
Agonist-induced down-regulation of the beta2-adrenoceptor and its mRNA in human mononuclear leukocytes. Biochemical pharmacology, 1998, Oct-15, Volume: 56, Issue:8 Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Adult; Down-Regulation; Half-Life; Hu	1998
Use of sublingual nitroglycerin during head-up tilt-table testing in patients >60 years of age. The American journal of cardiology, 1998, Nov-15, Volume: 82, Issue:10 Topics: Administration, Sublingual; Aged; Bradycardia; Cardiotonic Agents; Dose-Response Relationship, Drug;	1998
Utility of a single-stage isoproterenol tilt table test in adults: a randomized comparison with passive head-up tilt. Journal of the American College of Cardiology, 1999, Mar-15, Volume: 33, Issue:4 Topics: Adult; Aged; Cross-Over Studies; Diagnosis, Differential; Female; Humans; Isoproterenol; Male; Middl	1999
Value of sublingual isosorbide dinitrate before isoproterenol tilt test for diagnosis of neurally mediated syncope. The American journal of cardiology, 1999, Apr-01, Volume: 83, Issue:7 Topics: Administration, Sublingual; Adult; Blood Pressure; Female; Heart Rate; Humans; Isoproterenol; Isosor	1999
Comparing two different protocols for tilt table testing: sublingual glyceryl trinitrate versus isoprenaline infusion. Heart (British Cardiac Society), 1999, Volume: 81, Issue:6 Topics: Adolescent; Adult; Cardiotonic Agents; Female; Humans; Isoproterenol; Male; Middle Aged; Nitroglycer	1999
Monitoring of beta-receptor sensitivity in cardiac surgery. Journal of cardiothoracic and vascular anesthesia, 1999, Volume: 13, Issue:4 Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Cardiac Output;	1999
[Methodology of 80 degrees head-up tilt testing with and without low dose isoproterenol provocation in Japanese patients with neurally mediated syncope]. Journal of cardiology, 2000, Volume: 35, Issue:5 Topics: Adult; Aged; Asian People; Female; Humans; Isoproterenol; Japan; Male; Middle Aged; Sensitivity and	2000
Oral clonidine premedication does not change efficacy of simulated epidural test dose in sevoflurane-anesthetized children. Anesthesiology, 2000, Volume: 93, Issue:4 Topics: Administration, Oral; Adrenergic Agonists; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Anal	2000
Comparison of provocative tests for unexplained syncope: isoprenaline and glyceryl trinitrate for diagnosing vasovagal syncope. European heart journal, 2001, Volume: 22, Issue:6 Topics: Adult; Aged; Female; Humans; Isoproterenol; Male; Middle Aged; Nitroglycerin; Sensitivity and Specif	2001
Relative sensitivity of four noninvasive methods in assessing systolic cardiovascular effects of isoproterenol in healthy volunteers. Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:6 Topics: Adult; Analysis of Variance; Aorta; Blood Flow Velocity; Cardiography, Impedance; Cardiovascular Sys	1992
Evaluation of syncope by upright tilt testing with isoproterenol. A nonspecific test. Annals of internal medicine, 1992, Mar-01, Volume: 116, Issue:5 Topics: Adolescent; Adult; Bradycardia; Female; Humans; Hypotension, Orthostatic; Isoproterenol; Male; Middl	1992

Article	Year
Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor. Nature chemical biology, 2006, Volume: 2, Issue:8 Topics: Adrenergic beta-2 Receptor Agonists; Albuterol; Alprenolol; Amino Acid Sequence; Binding Sites; Crys	2006
Hyperpolarized 13C NMR detects rapid drug-induced changes in cardiac metabolism. Magnetic resonance in medicine, 2015, Volume: 74, Issue:2 Topics: Adrenergic beta-Agonists; Animals; Carbon Isotopes; Carbon-13 Magnetic Resonance Spectroscopy; Glyco	2015
[Comparison of the use of isoproterenol or nitroglycerine during the Tilt test]. Revista medica de Chile, 2015, Volume: 143, Issue:1 Topics: Administration, Sublingual; Adolescent; Adult; Aged; Aged, 80 and over; Child; Female; Humans; Isopr	2015
Nasal potential difference outcomes support diagnostic decisions in cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2016, Volume: 15, Issue:5 Topics: Adrenergic beta-Agonists; Adult; Amiloride; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductan	2016
Type III Transforming Growth Factor-β Receptor Drives Cardiac Hypertrophy Through β-Arrestin2-Dependent Activation of Calmodulin-Dependent Protein Kinase II. Hypertension (Dallas, Tex. : 1979), 2016, Volume: 68, Issue:3 Topics: Analysis of Variance; Animals; beta-Arrestin 2; Biopsy, Needle; Calcium-Calmodulin-Dependent Protein	2016
Sex-Specific Effects of Adrenergic-Induced Left Ventricular Remodeling in Spontaneously Hypertensive Rats. Journal of cardiac failure, 2017, Volume: 23, Issue:2 Topics: Adrenergic Agents; Animals; Cells, Cultured; Disease Models, Animal; Female; Isoproterenol; Male; My	2017
Serotonin 5-HT(2B) receptor blockade prevents reactive oxygen species-induced cardiac hypertrophy in mice. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 52, Issue:2 Topics: Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Echocardiography, Doppler; Indoles; I	2008
Sensitive determination of norepinephrine, synephrine, and isoproterenol by capillary electrophoresis with indirect electrochemiluminescence detection. Journal of separation science, 2008, Volume: 31, Issue:13 Topics: 2,2'-Dipyridyl; Body Fluids; Buffers; Diabetes Mellitus; Electrochemistry; Electrophoresis, Capillar	2008
Ultrasensitive cross-species measurement of cardiac troponin-I using the Erenna immunoassay system. Toxicologic pathology, 2008, Volume: 36, Issue:6 Topics: Animals; Biomarkers; Dogs; Female; Heart Diseases; Humans; Immunoassay; Isoproterenol; Linear Models	2008
Head-up tilt table testing in syncope: safety and efficiency of isosorbide versus isoproterenol in pediatric population. American heart journal, 2008, Volume: 156, Issue:3 Topics: Administration, Sublingual; Adolescent; Blood Pressure; Bradycardia; Child; Female; Heart Rate; Huma	2008
Regulation of renovascular adenosine 3',5'-cyclic monophosphate in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979), 2009, Volume: 54, Issue:2 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Analysis of Variance; Animals; Blood Pressure; Blood	2009
Gene expression profiling: classification of mice with left ventricle systolic dysfunction using microarray analysis. Critical care medicine, 2010, Volume: 38, Issue:1 Topics: Animals; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Isoprotereno	2010
Time course characterization of serum cardiac troponins, heart fatty acid-binding protein, and morphologic findings with isoproterenol-induced myocardial injury in the rat. Toxicologic pathology, 2010, Volume: 38, Issue:5 Topics: Animals; Biomarkers; Cardiotonic Agents; Fatty Acid-Binding Proteins; Heart; Heart Injuries; Immunoa	2010
Antiarrhythmic effects of simvastatin in canine pulmonary vein sleeve preparations. Journal of the American College of Cardiology, 2011, Feb-22, Volume: 57, Issue:8 Topics: Acetylcholine; Action Potentials; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Dogs; Dose-Respo	2011
A comparison of mortality and cardiac biomarker response between three outbred stocks of Sprague Dawley rats treated with isoproterenol. Toxicologic pathology, 2011, Volume: 39, Issue:4 Topics: Animals; Biomarkers; Dose-Response Relationship, Drug; Fatty Acid Binding Protein 3; Fatty Acid-Bind	2011
Velocity vector imaging fails to quantify regional myocardial dysfunction in a mouse model of isoprenaline-induced cardiotoxicity. Echocardiography (Mount Kisco, N.Y.), 2012, Volume: 29, Issue:7 Topics: Algorithms; Animals; Disease Models, Animal; Echocardiography; Elasticity Imaging Techniques; Humans	2012
Paroxysmal atrioventricular block precipitated by an atrial premature beat. What is the mechanism? Cardiology journal, 2012, Volume: 19, Issue:6 Topics: Adrenergic beta-Agonists; Aged; Atrial Premature Complexes; Atrioventricular Block; Electrocardiogra	2012
Stable, sensitive, fluorescence-based method for detecting cAMP. BioTechniques, 2002, Volume: 33, Issue:3 Topics: Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Fluorescence Polarization Immunoassay; Huma	2002
Influence of castration on isoprenaline-induced amylase release in parotid gland from male rats. Experimental physiology, 2002, Volume: 87, Issue:4 Topics: Adrenergic beta-Agonists; Amylases; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Isoproter	2002
HPLC determination of catecholamines based on precolumn derivatization with 6-aminomethylphthalhydrazide followed by chemiluminescence detection. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2002, Volume: 18, Issue:12 Topics: Calibration; Catecholamines; Chromatography, High Pressure Liquid; Epinephrine; Isoproterenol; Lumin	2002
Arrhythmogenic substrate of the pulmonary veins assessed by high-resolution optical mapping. Circulation, 2003, Apr-08, Volume: 107, Issue:13 Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Function; Cardiac Paci	2003
Very low-frequency heart rate variability wave amplitude and sympathetic stimulation--characterization and modeling. IEEE transactions on bio-medical engineering, 2003, Volume: 50, Issue:7 Topics: Animals; Computer Simulation; Dose-Response Relationship, Drug; Fourier Analysis; Heart; Heart Rate;	2003
Chiral analysis of neurotransmitters using cyclodextrin-modified capillary electrophoresis equipped with microfabricated interdigitated electrodes. Journal of chromatography. A, 2003, Jun-27, Volume: 1003, Issue:1-2 Topics: Cyclodextrins; Electrochemistry; Electrodes; Electrophoresis, Capillary; Epinephrine; Isoproterenol;	2003
What is the optimal increase in resting heart rate with low dose isoproterenol infusion for tilt-induced vasovagal response? Journal of cardiovascular pharmacology, 2003, Volume: 42 Suppl 1 Topics: Adult; Aged; Female; Heart Rate; Humans; Infusions, Intravenous; Isoproterenol; Male; Middle Aged; R	2003
IL-8 inhibits isoproterenol-stimulated ciliary beat frequency in bovine bronchial epithelial cells. Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine, 2004,Summer, Volume: 17, Issue:2 Topics: Animals; Bronchi; Cattle; Cells, Cultured; Cilia; Cyclic AMP-Dependent Protein Kinases; Drug Interac	2004
Measuring transient systemic conductance and capacitance responses using a modified Brooksby-Donald technique in anesthetized, autonomically intact rabbits. The Canadian journal of cardiology, 2004, Volume: 20, Issue:11 Topics: Analysis of Variance; Animals; Blood Flow Velocity; Disease Models, Animal; Female; Injections, Intr	2004
The effect of varying tonicity on nasal epithelial ion transport in cystic fibrosis. American journal of respiratory and critical care medicine, 2005, Apr-01, Volume: 171, Issue:7 Topics: Adult; Amiloride; Case-Control Studies; Culture Techniques; Cystic Fibrosis; Cystic Fibrosis Transme	2005
Reproducibility of nitrate-stimulated tilt testing in patients with suspected vasovagal syncope and a healthy control group. American heart journal, 2005, Volume: 150, Issue:2 Topics: Adolescent; Adult; Aged; Blood Pressure; Electrocardiography; Female; Heart Arrest; Heart Rate; Hemo	2005
Increased sensitivity of electrophysiological study by isoproterenol infusion in unexplained syncope. International journal of cardiology, 2006, Jan-04, Volume: 106, Issue:1 Topics: Cardiotonic Agents; Electrophysiologic Techniques, Cardiac; Female; Humans; Isoproterenol; Male; Mid	2006
Comparison of G-protein coupled receptor desensitization-related beta-arrestin redistribution using confocal and non-confocal imaging. Combinatorial chemistry & high throughput screening, 2006, Volume: 9, Issue:1 Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Arrestins; beta-Arresti	2006
Cardioprotective effect of grape seed proanthocyanidins on isoproterenol-induced myocardial injury in rats. International journal of cardiology, 2007, Feb-14, Volume: 115, Issue:3 Topics: Animals; Biomarkers; Biopsy, Needle; Blood Chemical Analysis; Cardiotonic Agents; Disease Models, An	2007
The CF-CIRC study: a French collaborative study to assess the accuracy of cystic fibrosis diagnosis in neonatal screening. BMC pediatrics, 2006, Oct-03, Volume: 6 Topics: Amiloride; Catheterization; Child, Preschool; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembr	2006
A CE assay for the detection of agonist-stimulated adenylyl cyclase activity. Electrophoresis, 2007, Volume: 28, Issue:12 Topics: Adenylyl Cyclases; Biological Assay; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Res	2007
Determination of catecholamines by CE with direct chemiluminescence detection. Electrophoresis, 2007, Volume: 28, Issue:12 Topics: Buffers; Catecholamines; Dopamine; Electrophoresis, Capillary; Epinephrine; Flow Injection Analysis;	2007
In vitro sensitivity of mouse esophagus to agonists in different pH medium values. Journal of pediatric surgery, 2007, Volume: 42, Issue:12 Topics: Acetylcholine; Adrenergic beta-Agonists; Analysis of Variance; Animals; Carbachol; Cholinergic Agoni	2007
Atrial fibrillation induction with isoproterenol: teaching an old drug new tricks. Journal of cardiovascular electrophysiology, 2008, Volume: 19, Issue:5 Topics: Adrenergic beta-Agonists; Adult; Atrial Fibrillation; Dose-Response Relationship, Drug; Electrocardi	2008
Upright postures and isoproterenol infusion for provocation of neurocardiogenic syncope: a comparison of standing and head-up tilting. American heart journal, 1995, Volume: 130, Issue:6 Topics: Adult; Blood Pressure; Female; Heart Function Tests; Heart Rate; Humans; Isoproterenol; Male; Middle	1995
Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes. The Journal of biological chemistry, 1995, Nov-24, Volume: 270, Issue:47 Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cell Line; Cysteine; Dihydroalprenol	1995
Comparison of spectral temporal mapping to the time domain signal-averaged electrocardiogram in normal subjects and in patients with coronary artery disease and sustained ventricular tachycardia. Pacing and clinical electrophysiology : PACE, 1994, Volume: 17, Issue:5 Pt 1 Topics: Action Potentials; Adult; Bundle-Branch Block; Cardiac Pacing, Artificial; Coronary Disease; Electro	1994
Highly sensitive and specific HPLC with fluorometric detection for determination of plasma epinephrine and norepinephrine applied to kinetic studies in humans. Clinical chemistry, 1995, Volume: 41, Issue:10 Topics: Adult; Arteries; Chromatography, High Pressure Liquid; Dopamine; Epinephrine; Humans; Isoproterenol;	1995
Diagnostic accuracy of a low-dose isoproterenol head-up tilt protocol. American heart journal, 1995, Volume: 129, Issue:5 Topics: Adult; Analysis of Variance; Chi-Square Distribution; Electrocardiography; False Positive Reactions;	1995
Regional myocardial function curve of the ventricle. Heart and vessels, 1995, Volume: 10, Issue:2 Topics: Animals; Dogs; Electrocardiography; Isoproterenol; Myocardial Contraction; Propranolol; Regression A	1995
Modulation of electrically evoked [3H]-noradrenaline release from cultured chick sympathetic neurons. Naunyn-Schmiedeberg's archives of pharmacology, 1994, Volume: 350, Issue:3 Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Calcium Channels; Cells, Cultured	1994
Screening of cattle urine samples for the presence of beta-agonists with a functional test: some preliminary results. The Analyst, 1994, Volume: 119, Issue:12 Topics: Adrenergic beta-Agonists; Animals; Cattle; Chromatography, Ion Exchange; Clenbuterol; Guinea Pigs; I	1994
Catecholamine interference with enzymatic determination of nonesterified fatty acids in two commercially available test kits. Clinical chemistry, 1995, Volume: 41, Issue:3 Topics: Acyl-CoA Oxidase; Catecholamines; Coenzyme A Ligases; Epinephrine; Fatty Acids, Nonesterified; Human	1995
Forced swim stress: supersensitivity of the isolated rat pacemaker to the chronotropic effect of isoprenaline and the role of corticosterone. General pharmacology, 1994, Volume: 25, Issue:7 Topics: Adrenal Glands; Adrenalectomy; Animals; Atrial Function, Right; Biological Clocks; Corticosterone; D	1994
Esmolol tilt testing with esmolol withdrawal for the evaluation of syncope in the young. Circulation, 1994, Volume: 89, Issue:1 Topics: Adolescent; Adrenergic beta-Antagonists; Bradycardia; Contraindications; Female; Humans; Hypotension	1994
Hemodynamic and volumetric response of the normal left ventricle to upright tilt testing. American heart journal, 1994, Volume: 128, Issue:1 Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Bradycardia; Cardiac Output; Cardiac Volume; Ech	1994
[Tilt test: hemodynamic responses in patients with syncope or presyncope of unknown etiology]. Revista medica de Chile, 1993, Volume: 121, Issue:12 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Heart Rate; Humans; Hypotension, Orthostatic; Is	1993
A simple and rapid HPLC assay for quantitating cyclic AMP accumulation in intact cell preparations. Journal of pharmacological and toxicological methods, 1994, Volume: 31, Issue:1 Topics: Animals; Chromatography, High Pressure Liquid; Colon; Cyclic AMP; Female; Guinea Pigs; Isoproterenol	1994
Nitroglycerin infusion during upright tilt: a new test for the diagnosis of vasovagal syncope. American heart journal, 1994, Volume: 127, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Case-Control Studies; Female; Heart Rate; Humans; Is	1994
Halothane and pertussis toxin-sensitive G proteins in airway smooth muscle. Anesthesia and analgesia, 1994, Volume: 78, Issue:2 Topics: Acetylcholine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Depression, Chemical; Dogs; Drug	1994
Inhibition of cyclic AMP accumulation by endothelin is pertussis toxin sensitive and calcium independent in isolated adult feline cardiac myocytes. Life sciences, 1996, Volume: 58, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic beta-Antagonists	1996
Ozone-induced alteration in beta-adrenergic pharmacological modulation of pulmonary macrophages. Toxicology and applied pharmacology, 1996, Volume: 137, Issue:1 Topics: Adrenergic beta-Agonists; Air Pollutants; Animals; Bronchoalveolar Lavage; Cells, Cultured; Isoprote	1996
Dysfunction in the beta 2-adrenergic signal pathway in patients with insulin dependent diabetes mellitus (IDDM) and unawareness of hypoglycaemia. European journal of clinical pharmacology, 1995, Volume: 48, Issue:5 Topics: Adrenergic beta-Agonists; Adult; Binding, Competitive; Diabetes Mellitus, Type 1; Female; Humans; Hy	1995
Beta-adrenergic receptor regulation of macrophage-derived tumor necrosis factor-alpha production from rats with experimental arthritis. Journal of neuroimmunology, 1996, Volume: 67, Issue:1 Topics: Animals; Arthritis, Experimental; Bacterial Proteins; Bucladesine; Cell Membrane; Dose-Response Rela	1996
Systemic beta-adrenoceptor function and ophthalmic beta-adrenergic blockers. Anesthesia and analgesia, 1996, Volume: 82, Issue:1 Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Heart Rate; Humans; Isoproterenol; Levobunolol; M	1996
Isoproterenol tilt-table testing in patients with syncope and structural heart disease. The American journal of cardiology, 1996, Sep-15, Volume: 78, Issue:6 Topics: Adrenergic beta-Agonists; Aged; Female; Heart Diseases; Hemodynamics; Humans; Isoproterenol; Male; M	1996
Sensitization of endogenous and recombinant adenylate cyclase by activation of D2 dopamine receptors. Molecular pharmacology, 1996, Volume: 50, Issue:4 Topics: Adenylyl Cyclases; Cells, Cultured; Colforsin; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists;	1996
Effects of calcium sensitizers on intracellular calcium handling and myocardial energetics. Journal of cardiovascular pharmacology, 1995, Volume: 26 Suppl 1 Topics: Adrenergic beta-Agonists; Aequorin; Animals; Calcium; Cardiotonic Agents; Energy Metabolism; Heart;	1995
Prospective evaluation of high-dose or low-dose isoproterenol upright tilt protocol for unexplained syncope in young adults. American heart journal, 1997, Volume: 133, Issue:3 Topics: Adrenergic beta-Agonists; Adult; Evaluation Studies as Topic; Female; Hemodynamics; Humans; Isoprote	1997
Negative and selective effects of propofol on isolated swine myocyte contractile function in pacing-induced congestive heart failure. Anesthesiology, 1997, Volume: 86, Issue:3 Topics: Adrenergic beta-Agonists; Anesthetics, Intravenous; Animals; Cardiac Pacing, Artificial; Cardiotonic	1997
[Should protocol of programmed ventricular stimulation be adapted to each patient? ]. Archives des maladies du coeur et des vaisseaux, 1996, Volume: 89, Issue:11 Topics: Cardiac Pacing, Artificial; Cardiotonic Agents; Coronary Disease; Electrocardiography; Follow-Up Stu	1996
Head-up tilt test in complicated neurocardiogenic syncope in children. Journal of Korean medical science, 1997, Volume: 12, Issue:1 Topics: Adolescent; Blood Pressure; Cardiotonic Agents; Child; Diagnosis, Differential; Electrocardiography;	1997
Regulation of corticotropin-releasing factor receptor function in human Y-79 retinoblastoma cells: rapid and reversible homologous desensitization but prolonged recovery. Journal of neurochemistry, 1997, Volume: 68, Issue:6 Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Blotting, Northern; Colforsin; Corticotropin-Releasing	1997
Comparison of sensitivity and specificity of tilt protocols with and without isoproterenol in children with unexplained syncope. Pacing and clinical electrophysiology : PACE, 1997, Volume: 20, Issue:7 Topics: Adrenergic beta-Agonists; Blood Pressure; Case-Control Studies; Child; Female; Heart Rate; Humans; I	1997
Responses of normal subjects during 80 degrees head upright tilt table testing with and without low dose isoproterenol infusion. Pacing and clinical electrophysiology : PACE, 1997, Volume: 20, Issue:8 Pt 1 Topics: Adult; Analysis of Variance; Chi-Square Distribution; Confidence Intervals; Female; Heart Rate; Huma	1997
Beta2-adrenergic receptor antagonists protect against ventricular fibrillation: in vivo and in vitro evidence for enhanced sensitivity to beta2-adrenergic stimulation in animals susceptible to sudden death. Circulation, 1997, Sep-16, Volume: 96, Issue:6 Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Agonist	1997
Tilt table testing of young adult patients: improved speed and sensitivity using an isoproterenol bolus and a continuous 60 degrees tilt. Pacing and clinical electrophysiology : PACE, 1998, Volume: 21, Issue:3 Topics: Adolescent; Adult; Blood Pressure; Diagnosis, Differential; Electrocardiography, Ambulatory; Follow-	1998
Induction of neurally mediated syncope with adenosine. Circulation, 1999, Mar-16, Volume: 99, Issue:10 Topics: Adenosine; Adult; Aged; Electrocardiography; Female; Hemodynamics; Humans; Isoproterenol; Male; Midd	1999
Specific changes in beta2-adrenoceptor trafficking kinetics and intracellular sorting during downregulation. European journal of pharmacology, 1999, Mar-12, Volume: 369, Issue:1 Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Biological Transport; Cell Line; Down-Regulat	1999
Coronary endothelial dysfunction of isolated hearts subjected to prolonged cold storage: patterns and contributing factors. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 1999, Volume: 18, Issue:3 Topics: Acetylcholine; Animals; Cold Temperature; Coronary Vessels; Dose-Response Relationship, Drug; Endoth	1999
Lectin binding sites in parotid acinar secretory granules of normal and isoproterenol treated rat. Journal of submicroscopic cytology and pathology, 1999, Volume: 31, Issue:1 Topics: Animals; Binding Sites; Carbohydrate Sequence; Carbohydrates; Cytoplasmic Granules; Isoproterenol; L	1999
Head-up tilt test in patients with high pretest likelihood of neurally mediated syncope: an approximation to the "real sensitivity" of this testing. Pacing and clinical electrophysiology : PACE, 1999, Volume: 22, Issue:8 Topics: Adolescent; Adrenergic beta-Agonists; Adult; Blood Pressure; Child; Child, Preschool; Echocardiograp	1999
Haemodynamic effects of increasing angle of head up tilt. Heart (British Cardiac Society), 2000, Volume: 83, Issue:2 Topics: Adult; Aged; Blood Pressure; Cardiac Output; Cardiotonic Agents; Female; Heart Rate; Hemodynamics; H	2000
Comparison of the diagnostic value of cardiac troponin I and T determinations for detecting early myocardial damage and the relationship with histological findings after isoprenaline-induced cardiac injury in rats. Clinica chimica acta; international journal of clinical chemistry, 2000, Volume: 298, Issue:1-2 Topics: Animals; Antibodies, Monoclonal; Cardiomyopathies; Creatine Kinase; Heart Diseases; Isoproterenol; K	2000
Determination of urine catecholamines by capillary electrophoresis with dual-electrode amperometric detection. Journal of chromatography. B, Biomedical sciences and applications, 2001, Jan-05, Volume: 750, Issue:1 Topics: Catecholamines; Electrochemistry; Electrophoresis, Capillary; Humans; Isoproterenol; Reference Stand	2001
Tilt testing in neurocardiogenic syncope: isosorbide versus isoproterenol. Acta cardiologica, 2000, Volume: 55, Issue:6 Topics: Administration, Sublingual; Adolescent; Adrenergic beta-Agonists; Adult; Aged; Confidence Intervals;	2000
Effects of isoproterenol on spontaneous excitations in detrusor smooth muscle cells of the guinea pig. The Journal of urology, 2001, Volume: 166, Issue:1 Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Calcium; Cells, Cultured; Guinea Pigs; Isoprot	2001
Adrenergic-cholinergic interaction that modulates repolarization in the atrium is altered with aging. Journal of cardiovascular electrophysiology, 2002, Volume: 13, Issue:4 Topics: Acetylcholine; Action Potentials; Adrenergic beta-Agonists; Aging; Animals; Dogs; Dose-Response Rela	2002
A comparison of a single-stage isoproterenol tilt table test protocol with conventional two-staged tilt protocol in patients with syncope. The Journal of invasive cardiology, 2002, Volume: 14, Issue:7 Topics: Female; Humans; Isoproterenol; Male; Prospective Studies; Sensitivity and Specificity; Syncope; Tilt	2002
Desensitization of beta-adrenoceptor- and prostaglandin E1 receptor-mediated human vascular smooth muscle relaxation. Journal of cardiovascular pharmacology, 1992, Volume: 19, Issue:3 Topics: Alprostadil; Dose-Response Relationship, Drug; Hand; Humans; Isoproterenol; Muscle Relaxation; Muscl	1992
Heart rate variations during isoproterenol infusion in congestive heart failure: relationships to cardiac mortality. American heart journal, 1992, Volume: 123, Issue:4 Pt 1 Topics: Adult; Aged; Cardiac Pacing, Artificial; Death, Sudden, Cardiac; Female; Follow-Up Studies; Heart Fa	1992
Contribution of the dynamic phonocardiography to the valvular heart disease diagnosis: an expert system study. Acta cardiologica, 1990, Volume: 45, Issue:6 Topics: Adult; Electrocardiography; Expert Systems; Female; Heart Rate; Heart Valve Diseases; Humans; Isopro	1990
A prospective comparison of programmed ventricular stimulation with triple extrastimuli versus single and double extrastimuli during infusion of isoproterenol. American heart journal, 1989, Volume: 117, Issue:2 Topics: Aged; Cardiac Pacing, Artificial; Electrophysiology; Heart; Heart Ventricles; Humans; Isoproterenol;	1989
Use of the valvular resistance in the separation of normal and stenotic Hancock mitral valves. Journal of cardiac surgery, 1988, Volume: 3, Issue:3 Topics: Cardiac Catheterization; Cardiac Pacing, Artificial; Evaluation Studies as Topic; Heart Valve Prosth	1988
[Thallium-201 myocardial single photon emission computed tomography after isoproterenol infusion in diagnosing ischemic heart disease]. Kaku igaku. The Japanese journal of nuclear medicine, 1988, Volume: 25, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Coronary Disease; Female; Humans; Isoproterenol; Male; Middle Aged;	1988
Ability of the electrocardiogram to detect myocardial lesions in isoproterenol induced rat cardiomyopathy. Cardiovascular research, 1987, Volume: 21, Issue:12 Topics: Ajmaline; Animals; Cardiomyopathies; Electrocardiography; Heart; Isoproterenol; Male; Myocardium; Ra	1987

isoproterenol and Sensitivity and Specificity