isoproterenol has been researched along with Parkinson Disease in 17 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Patients with PD+NOH had normal bradycardia responses to edrophonium and normal epinephrine responses to glucagon." | 3.74 | Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension. ( Goldstein, DS; Holmes, C; Imrich, R; Pechnik, S; Sharabi, Y, 2008) |
| "Diseases characterized by neurogenic orthostatic hypotension (NOH), such as Parkinson disease (PD) and pure autonomic failure (PAF), are associated with cardiac sympathetic denervation, as reflected by low myocardial concentrations of 6-[(18)F]fluorodopamine-derived radioactivity." | 1.35 | Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension. ( Bentho, O; Eldadah, BA; Goldstein, DS; Grossman, E; Holmes, C; Imrich, R; Pechnik, S; Sharabi, Y, 2009) |
| "We studied 10 Parkinson's disease patients and examined adipose tissue and skeletal muscle metabolism directly with microdialysis." | 1.35 | Influences of levodopa on adipose tissue and skeletal muscle metabolism in patients with idiopathic Parkinson's disease. ( Adams, F; Boschmann, M; Franke, G; Gottschalk, S; Janke, J; Jordan, J; Kupsch, A; Leisse, MC; Lipp, A; Lobsien, E; Spranger, J, 2008) |
| "Certain clinical manifestations of Parkinson's disease (PD) (speech or/and balance disturbances) are not linked to brain dopamine deficiency." | 1.28 | Cardiac beta-adrenoceptor sensitivity and Parkinson's disease. ( Allain, H; Bentue-Ferrer, D; Decombe, R; Lemaitre, MH; Martinet, JP; Milon, D, 1991) |
| "The typical 'tremor-at-rest' of Parkinson's disease--3-7 Hz activity which alternates between antagonistic muscles--is suppressed, at least briefly, during voluntary activity, at which time typical 8--12 Hz 'physiological tremor' may be seen." | 1.26 | Physiological and pharmacological aids in the differential diagnosis of tremor. ( Shahani, BT; Young, RR, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (47.06) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weichert, D | 1 |
| Stanek, M | 1 |
| Hübner, H | 1 |
| Gmeiner, P | 1 |
| Lv, H | 1 |
| Yu, F | 1 |
| Sha, C | 1 |
| Huang, Y | 1 |
| Lu, Y | 1 |
| Zhang, L | 1 |
| Zhai, R | 1 |
| Wang, T | 1 |
| Fu, F | 1 |
| Imrich, R | 2 |
| Eldadah, BA | 1 |
| Bentho, O | 1 |
| Pechnik, S | 2 |
| Sharabi, Y | 2 |
| Holmes, C | 2 |
| Grossman, E | 1 |
| Goldstein, DS | 2 |
| Adams, F | 1 |
| Boschmann, M | 1 |
| Lobsien, E | 1 |
| Kupsch, A | 1 |
| Lipp, A | 1 |
| Franke, G | 1 |
| Leisse, MC | 1 |
| Janke, J | 1 |
| Gottschalk, S | 1 |
| Spranger, J | 1 |
| Jordan, J | 1 |
| CONSTAS, C | 1 |
| Marsden, CD | 1 |
| Foley, TH | 1 |
| Owen, DA | 1 |
| McAllister, RG | 1 |
| Hirayama, M | 1 |
| Hakusui, S | 1 |
| Koike, Y | 1 |
| Ito, K | 1 |
| Kato, T | 1 |
| Ikeda, M | 1 |
| Hasegawa, Y | 1 |
| Takahashi, A | 1 |
| Ishikawa, A | 1 |
| Shahani, BT | 2 |
| Young, RR | 2 |
| Milon, D | 1 |
| Allain, H | 1 |
| Bentue-Ferrer, D | 1 |
| Martinet, JP | 1 |
| Lemaitre, MH | 1 |
| Decombe, R | 1 |
| Durrieu, G | 1 |
| Rispail, Y | 1 |
| Chatelut, E | 1 |
| Berlan, M | 1 |
| Rascol, A | 1 |
| Montastruc, JL | 1 |
| Montastruc, P | 1 |
| Papavasiliou, PS | 1 |
| Miller, ST | 1 |
| Cotzias, GC | 1 |
| Jacobi, H | 1 |
| von Egidy, H | 1 |
| Vollum, DI | 1 |
| Parkes, JD | 1 |
| Doyle, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Identifying the Pathophysiology of Neurogenic Orthostatic Hypotension and the Effects of Melatonin on Reducing Supine Hypertension in Peripherally Intact Versus Denervated Post-ganglionic Sympathetic Nerves[NCT02963181] | Early Phase 1 | 10 participants (Actual) | Interventional | 2018-03-01 | Terminated (stopped due to PI leaving) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for isoproterenol and Parkinson Disease
| Article | Year |
|---|---|
[Progress in diagnosis and treatment of juvenile parkinsonism].
Topics: Adolescent; Adult; Age of Onset; Child; Drug Tolerance; Female; Humans; Isoproterenol; Levodopa; Mal | 1993 |
1 trial available for isoproterenol and Parkinson Disease
| Article | Year |
|---|---|
Peripheral beta-adrenergic receptors concerned with tremor.
Topics: Adult; Arteries; Blood Circulation; Bradykinin; Catecholamines; Epinephrine; Fingers; Forearm; Human | 1967 |
15 other studies available for isoproterenol and Parkinson Disease
| Article | Year |
|---|---|
Structure-guided development of dual β2 adrenergic/dopamine D2 receptor agonists.
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Benzoxazines; CHO Cells; Cricetulus; Dopamine Agonists | 2016 |
Effects of rotigotine and rotigotine extended-release microsphere therapy on myocardial ischemic injury in mice.
Topics: Animals; Cardiotonic Agents; Chlorpromazine; Creatine Kinase, MB Form; Dopamine Agonists; Isoprotere | 2019 |
Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension.
Topics: Adrenergic beta-Agonists; Aged; Autonomic Nervous System Diseases; Blood Pressure; Dopamine; Female; | 2009 |
Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension.
Topics: Aged; Blood Pressure; Bradycardia; Cholinesterase Inhibitors; Edrophonium; Epinephrine; Female; Gluc | 2008 |
Influences of levodopa on adipose tissue and skeletal muscle metabolism in patients with idiopathic Parkinson's disease.
Topics: Adipocytes; Adipose Tissue; Aged; Antiparkinson Agents; Benserazide; Dose-Response Relationship, Dru | 2008 |
The effects of adrenaline, noradrenaline, and isoprenaline on parkinsonian tremor.
Topics: Epinephrine; Humans; Isoproterenol; Norepinephrine; Parkinson Disease; Sympathomimetics; Tremor | 1962 |
A scintigraphical qualitative analysis of peripheral vascular sympathetic function with meta-[123I]iodobenzylguanidine in neurological patients with autonomic failure.
Topics: 3-Iodobenzylguanidine; Aged; Autonomic Nervous System Diseases; Female; Humans; Iodine Radioisotopes | 1995 |
Physiological and pharmacological aids in the differential diagnosis of tremor.
Topics: Ataxia; Diagnosis, Differential; Ethanol; Humans; Isoproterenol; Levodopa; Methods; Parkinson Diseas | 1976 |
Analysis of single motor unit discharge patterns in different types of tremor.
Topics: Humans; Isoproterenol; Motor Neurons; Parkinson Disease; Receptors, Adrenergic, beta; Tremor | 1978 |
Cardiac beta-adrenoceptor sensitivity and Parkinson's disease.
Topics: Aged; Aging; Blood Pressure; Bromocriptine; Dose-Response Relationship, Drug; Female; Heart Rate; Hu | 1991 |
Beta-adrenergic sensitivity in Parkinson's disease: effect of levodopa treatment.
Topics: Aged; Dose-Response Relationship, Drug; Epinephrine; Fatty Acids, Nonesterified; Female; Heart Rate; | 1990 |
Functional interactions between biogenic amines, 3',5'-cyclic AMP and manganese.
Topics: Adenine Nucleotides; Animals; Bile; Cyclic AMP; Dihydroxyphenylalanine; Dopamine; Epinephrine; Gluca | 1968 |
[Inhibition of tremor by active beta-adrenolytic substances].
Topics: Animals; Depression, Chemical; Isoproterenol; Mice; Parkinson Disease; Propranolol; Sensory Receptor | 1967 |
[What is assured in treatment with beta receptor blockaders?].
Topics: Acetanilides; Adrenergic beta-Antagonists; Alprenolol; Amino Alcohols; Cresols; Heart Diseases; Huma | 1972 |
Livedo reticularis during amantadine treatment.
Topics: Aged; Amantadine; Ankle; Blood Vessels; Edema; Epinephrine; Female; Humans; Isoproterenol; Male; Mid | 1971 |