Compounds > isoproterenol
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isoproterenol and Osteosarcoma

isoproterenol has been researched along with Osteosarcoma in 24 studies

Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.

Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)

Research Excerpts

ExcerptRelevanceReference
"In human osteosarcoma membranes, gold(III) (Au(III)) inhibits prostaglandin E2- and isoproterenol-mediated stimulation of adenylate cyclase activity without affecting basal enzyme activity."7.67Gold(III) inhibits activated human osteosarcoma adenylate cyclase by an action at or near the catalytic component. ( Keck, E; van Valen, F, 1987)
"A clonal cell line from rat osteosarcoma was found to possess parathyroid hormone and isoproterenol sensitive adenylate cyclase."7.66Parathyroid hormone and isoproterenol stimulation of adenylate cyclase in rat osteosarcoma clonal cells. Hormone competition and site heterogeneity. ( Rodan, GA; Rodan, SB, 1981)
" The ability of propranolol to modulate parathyroid hormone (PTH) and isoproterenol effects on adenylate cyclase activity and on alkaline phosphatase expression was studied in the osteoblast-like rat osteosarcoma cell line ROS 17/2."3.68Effects of beta-adrenergic blockade in an osteoblast-like cell line. ( Bastian, W; Einhorn, TA; Majeska, RJ; Minkowitz, B, 1992)
"In human osteosarcoma membranes, gold(III) (Au(III)) inhibits prostaglandin E2- and isoproterenol-mediated stimulation of adenylate cyclase activity without affecting basal enzyme activity."3.67Gold(III) inhibits activated human osteosarcoma adenylate cyclase by an action at or near the catalytic component. ( Keck, E; van Valen, F, 1987)
"A clonal cell line from rat osteosarcoma was found to possess parathyroid hormone and isoproterenol sensitive adenylate cyclase."3.66Parathyroid hormone and isoproterenol stimulation of adenylate cyclase in rat osteosarcoma clonal cells. Hormone competition and site heterogeneity. ( Rodan, GA; Rodan, SB, 1981)
"Isoproterenol stimulation was also enhanced."1.27The effect of dexamethasone on parathyroid hormone stimulation of adenylate cyclase in ROS 17/2.8 cells. ( Egan, JJ; Epstein, PM; Fischer, MK; Rodan, GA; Rodan, SB, 1984)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199018 (75.00)18.7374
1990's5 (20.83)18.2507
2000's1 (4.17)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, X1
Dai, JC1
Greenfield, EM1
Rodan, SB7
Fischer, MK1
Egan, JJ1
Epstein, PM1
Rodan, GA11
Majeska, RJ4
Gutierrez, GE3
Mundy, GR3
Katz, MS3
Shih, M1
Malbon, CC2
Glusman, J1
Morris, SA1
Rohde, S1
Chen, G1
Camacho, JA1
Bilezikian, JP1
Wang, HY1
Liao, JF1
Atkins, D1
Hunt, NH1
Ingleton, PM1
Martin, TJ1
Minkowitz, B1
Bastian, W1
Einhorn, TA1
Manning, DR1
Hewlett, EL1
Merendino, JJ1
Insogna, KL1
Milstone, LM1
Broadus, AE1
Stewart, AF1
Noda, M2
Yoon, K1
Barling, PM1
Bennett, JH1
Triffitt, JT1
Owen, ME1
Catherwood, BD1
Imai, Y1
van Valen, F1
Keck, E1
Nair, BC1

Other Studies

24 other studies available for isoproterenol and Osteosarcoma

ArticleYear
Termination of immediate-early gene expression after stimulation by parathyroid hormone or isoproterenol.
    American journal of physiology. Cell physiology, 2002, Volume: 283, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; beta-Adrenergic Receptor Kinases; Colforsin; Cyclic

2002
The effect of dexamethasone on parathyroid hormone stimulation of adenylate cyclase in ROS 17/2.8 cells.
    Endocrinology, 1984, Volume: 115, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Cell Line; Colforsin; Corticosteron

1984
Parathyroid hormone and isoproterenol stimulation of adenylate cyclase in rat osteosarcoma clonal cells. Hormone competition and site heterogeneity.
    Biochimica et biophysica acta, 1981, Feb-18, Volume: 673, Issue:1

    Topics: Adenylyl Cyclases; Animals; Binding Sites; Binding, Competitive; Cattle; Cell Line; Dose-Response Re

1981
Alkaline phosphatase inhibition by parathyroid hormone and isoproterenol in a clonal rat osteosarcoma cell line. Possible mediation by cyclic AMP.
    Calcified tissue international, 1982, Volume: 34, Issue:1

    Topics: Alkaline Phosphatase; Animals; Bone Neoplasms; Bucladesine; Cell Line; Cyclic AMP; Electrophoresis,

1982
Hormone-adenylate cyclase coupling in osteosarcoma clonal cell lines.
    Advances in cyclic nucleotide and protein phosphorylation research, 1984, Volume: 17

    Topics: Adenylyl Cyclases; Animals; Cell Line; Clone Cells; Drug Interactions; Enzyme Activation; Isoprotere

1984
Adenylate cyclase of osteoblast-like cells from rat osteosarcoma is stimulated by calcitonin as well as parathyroid hormone.
    Endocrinology, 1984, Volume: 115, Issue:6

    Topics: Adenylyl Cyclases; Animals; Calcitonin; Clone Cells; Enzyme Activation; Guanine Nucleotides; Isoprot

1984
The role of Mg2+ in hormone stimulation of rat osteosarcoma adenylate cyclase.
    Biochimica et biophysica acta, 1981, Feb-18, Volume: 673, Issue:1

    Topics: Adenylyl Cyclases; Animals; Cattle; Cell Line; Dose-Response Relationship, Drug; Guanosine Triphosph

1981
Oligodeoxynucleotides antisense to mRNA encoding protein kinase A, protein kinase C, and beta-adrenergic receptor kinase reveal distinctive cell-type-specific roles in agonist-induced desensitization.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, Dec-06, Volume: 91, Issue:25

    Topics: Animals; Base Sequence; beta-Adrenergic Receptor Kinases; Cell Line; CHO Cells; Cricetinae; Cyclic A

1994
Opposing influences of dexamethasone and retinoic acid on adenylate cyclase activity in ROS 17/2.8 cells.
    Endocrinology, 1993, Volume: 132, Issue:1

    Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Amino Acid Sequence; Blotting, Northern; Cell Membr

1993
Agonist regulation of beta-adrenergic receptors: immunoblotting and indirect immunofluorescence reveal agonist-induced lateral sequestration and loss of binding.
    The Chinese journal of physiology, 1996, Volume: 39, Issue:2

    Topics: Adrenergic beta-Agonists; Animals; Bone Neoplasms; Cell Membrane; Centrifugation, Density Gradient;

1996
Rat osteogenic sarcoma cells: isolation and effects of hormones on the production of cyclic AMP and cyclic GMP.
    Endocrinology, 1977, Volume: 101, Issue:2

    Topics: Adrenocorticotropic Hormone; Animals; Calcitonin; Cyclic AMP; Cyclic GMP; Glucagon; Glucose; Growth

1977
Maintenance of parathyroid hormone response in clonal rat osteosarcoma lines.
    Experimental cell research, 1978, Volume: 111, Issue:2

    Topics: Adenylyl Cyclases; Animals; Calcitonin; Clone Cells; Follicle Stimulating Hormone; Isoproterenol; Os

1978
Effects of beta-adrenergic blockade in an osteoblast-like cell line.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 1992, Volume: 10, Issue:3

    Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Alkaline Phosphatase; Animals; Bone Neoplasms; Dose-

1992
Transforming growth factor beta enhances parathyroid hormone stimulation of adenylate cyclase in clonal osteoblast-like cells.
    Journal of cellular physiology, 1990, Volume: 144, Issue:3

    Topics: Adenylyl Cyclases; Animals; Cholera Toxin; Colforsin; Dinoprostone; Isoproterenol; Osteoblasts; Oste

1990
A parathyroid hormone-like protein from cultured human keratinocytes.
    Science (New York, N.Y.), 1986, Jan-24, Volume: 231, Issue:4736

    Topics: Adenylyl Cyclases; Animals; Cattle; Cells, Cultured; Cyclic AMP; Epidermal Cells; Epidermis; Humans;

1986
Alterations in hormone-sensitive adenylate cyclase of cloned rat osteosarcoma cells during long-term culture.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1986, Volume: 1, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bone Neoplasms; Calcitonin; Dinoprostone; F

1986
Cyclic AMP-mediated stabilization of osteocalcin mRNA in rat osteoblast-like cells treated with parathyroid hormone.
    The Journal of biological chemistry, 1988, Dec-05, Volume: 263, Issue:34

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium-Binding Protei

1988
Transcriptional regulation of osteopontin production in rat osteoblast-like cells by parathyroid hormone.
    The Journal of cell biology, 1989, Volume: 108, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Western; Cal

1989
The adenylate cyclase response to parathyroid hormone in cultured rabbit marrow fibroblastic cells.
    Bone and mineral, 1989, Volume: 7, Issue:1

    Topics: Adenylyl Cyclases; Animals; Bone Marrow; Bone Marrow Cells; Cell Line; Cells, Cultured; Cyclic AMP;

1989
1,25-Dihydroxycholecalciferol and glucocorticosteroid regulation of adenylate cyclase in an osteoblast-like cell line.
    The Journal of biological chemistry, 1985, Jan-25, Volume: 260, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Calcitriol; Cell Line; Cholera Toxin; Colfo

1985
Effects of retinoic acid on alkaline phosphatase messenger ribonucleic acid, catecholamine receptors, and G proteins in ROS 17/2.8 cells.
    Endocrinology, 1988, Volume: 122, Issue:2

    Topics: Adenylyl Cyclases; Alkaline Phosphatase; Animals; Cell Division; Cholera Toxin; Cyclic AMP; Diphther

1988
Dexamethasone effects on beta-adrenergic receptors and adenylate cyclase regulatory proteins Gs and Gi in ROS 17/2.8 cells.
    Endocrinology, 1986, Volume: 118, Issue:6

    Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Animals; Cell Line; Cholera Toxin; Cyclic AMP; Cycl

1986
Gold(III) inhibits activated human osteosarcoma adenylate cyclase by an action at or near the catalytic component.
    Biochemical and biophysical research communications, 1987, May-14, Volume: 144, Issue:3

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Cell Line; Cell Membrane; Colforsin; Deoxyadenosines

1987
Glucocorticoid regulation of alkaline phosphatase in the osteoblastic osteosarcoma cell line ROS 17/2.8.
    Endocrinology, 1985, Volume: 116, Issue:1

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaline Phosphatase; Animals; Cell Division; Cell Line; Cyc

1985