isoproterenol has been researched along with Neuroblastoma in 33 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We identified receptors for neuropeptide Y (NPY) on an established human neuroblastoma cell line, SK-N-MC, which are functionally coupled to adenylate cyclase through the inhibitory guanine nucleotide-binding protein of adenylate cyclase, Gi." | 7.68 | Characterization of functional neuropeptide Y receptors in a human neuroblastoma cell line. ( Fishman, PH; Gordon, EA; Kohout, TA, 1990) |
| "C6 glioma cells respond to beta-adrenergic agonists (isoproterenol) with a transient rise in intracellular cyclic adenosine monophosphate level." | 7.67 | Neuroblastoma membranes inhibit isoproterenol-stimulated rise of cAMP in glioma cells. ( de Vellis, J; Wu, DK, 1984) |
| "Adenosine causes an increase in the concentration of cyclic AMP in mouse neuroblastoma cells." | 7.65 | Adenosine-mediated elevation of cyclic 3':5'-adenosine monophosphate concentrations in cultured mouse neuroblastoma cells. ( Blume, AJ; Dalton, C; Sheppard, H, 1973) |
| " Time course of candidate gene expression following adrenergic stimulation with isoproterenol was assayed in neuroblastoma cells by quantitative reverse transcription (RT)-PCR." | 3.73 | Association of DSC1, a gene modulated by adrenergic stimulation, with Alzheimer's disease. ( Bullido, MJ; Frank, A; Martínez-García, A; Ramos, MC; Rosich-Estragó, M; Sastre, I; Tenorio, R; Valdivieso, F; Vilella-Cuadrada, E, 2006) |
| "The mechanism underlying endothelin-1 (ET-1)-induced increases in intracellular Ca2+ concentrations in the human neuroblastoma cell-line SK-N-MC was investigated." | 3.70 | Mechanism of ET(A)-receptor stimulation-induced increases in intracellular Ca2+ in SK-N-MC cells. ( Brodde, OE; Heinroth-Hoffmann, I; Holtz, J; Morawietz, H; Pönicke, K; Schiewe, P; Vogelsang, M, 1998) |
| "In SK-N-MC human neuroblastoma cells, the cAMP response to 10 nM isoproterenol (ISO) is mediated primarily by beta 1-adrenergic receptors." | 3.68 | Coexisting beta 1- and atypical beta-adrenergic receptors cause redundant increases in cyclic AMP in human neuroblastoma cells. ( Esbenshade, TA; Granneman, JG; Han, C; Minneman, KP; Theroux, TL, 1992) |
| "Regulation of the expression of procholecystokinin (proCCK) and proenkephalin A mRNA was studied in the human neuroblastoma cell line SK-N-MC." | 3.68 | Procholecystokinin and proenkephalin A mRNA expression is modulated by cyclic AMP and noradrenaline. ( Folkesson, R; Geijer, T; Monstein, HJ, 1990) |
| "We identified receptors for neuropeptide Y (NPY) on an established human neuroblastoma cell line, SK-N-MC, which are functionally coupled to adenylate cyclase through the inhibitory guanine nucleotide-binding protein of adenylate cyclase, Gi." | 3.68 | Characterization of functional neuropeptide Y receptors in a human neuroblastoma cell line. ( Fishman, PH; Gordon, EA; Kohout, TA, 1990) |
| " Using [3H]DHA and unlabeled L-alprenolol, a substantial amount of over 64% specific binding of beta-adrenergic receptor has been identified on the neuroblastoma x glioma hybrid NG108-15 cell, which has been proven to display numerous functional characteristics of intact neurons." | 3.68 | Identification and characterization of the beta-adrenergic receptor on neuroblastoma x glioma hybrid NG108-15 cells. ( Cheng, KW; Ghahary, A, 1990) |
| "C6 glioma cells respond to beta-adrenergic agonists (isoproterenol) with a transient rise in intracellular cyclic adenosine monophosphate level." | 3.67 | Neuroblastoma membranes inhibit isoproterenol-stimulated rise of cAMP in glioma cells. ( de Vellis, J; Wu, DK, 1984) |
| "Adenosine causes an increase in the concentration of cyclic AMP in mouse neuroblastoma cells." | 3.65 | Adenosine-mediated elevation of cyclic 3':5'-adenosine monophosphate concentrations in cultured mouse neuroblastoma cells. ( Blume, AJ; Dalton, C; Sheppard, H, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (42.42) | 18.7374 |
| 1990's | 15 (45.45) | 18.2507 |
| 2000's | 4 (12.12) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ribas, C | 1 |
| Takesono, A | 1 |
| Sato, M | 1 |
| Hildebrandt, JD | 1 |
| Lanier, SM | 1 |
| Ramos, MC | 1 |
| Tenorio, R | 1 |
| Martínez-García, A | 1 |
| Sastre, I | 1 |
| Vilella-Cuadrada, E | 1 |
| Frank, A | 1 |
| Rosich-Estragó, M | 1 |
| Valdivieso, F | 1 |
| Bullido, MJ | 1 |
| Chan, AS | 1 |
| Ng, LW | 1 |
| Poon, LS | 1 |
| Chan, WW | 1 |
| Wong, YH | 1 |
| Wu, DK | 1 |
| de Vellis, J | 1 |
| Mullaney, I | 1 |
| Shah, BH | 1 |
| Wise, A | 1 |
| Milligan, G | 4 |
| Tamir, M | 1 |
| Kushner, L | 1 |
| Adie, EJ | 1 |
| McCrea, KE | 1 |
| Hill, SJ | 1 |
| Zhou, XM | 1 |
| Curran, P | 1 |
| Baumgold, J | 1 |
| Fishman, PH | 4 |
| Kim, GD | 2 |
| MacEwan, DJ | 1 |
| Sorrentino, G | 1 |
| Singh, IN | 1 |
| Massarelli, R | 1 |
| Kanfer, JN | 1 |
| Heinroth-Hoffmann, I | 1 |
| Vogelsang, M | 1 |
| Schiewe, P | 1 |
| Morawietz, H | 1 |
| Holtz, J | 1 |
| Pönicke, K | 1 |
| Brodde, OE | 1 |
| Jang, IS | 1 |
| Juhnn, YS | 1 |
| Schwartz, JP | 1 |
| Costa, E | 1 |
| Traber, J | 1 |
| Reiser, G | 1 |
| Fischer, K | 1 |
| Hamprecht, B | 1 |
| Bachrach, U | 2 |
| Penit, J | 1 |
| Huot, J | 1 |
| Jard, S | 1 |
| Volpe, JJ | 1 |
| Marasa, JC | 1 |
| Ortmann, R | 1 |
| Nutto, D | 1 |
| Waldmeyer, J | 1 |
| Lazarewicz, JW | 1 |
| Kanje, M | 1 |
| Sellström, A | 1 |
| Hamberger, A | 1 |
| Esbenshade, TA | 1 |
| Han, C | 1 |
| Theroux, TL | 1 |
| Granneman, JG | 1 |
| Minneman, KP | 1 |
| Sidhu, A | 1 |
| Monstein, HJ | 1 |
| Folkesson, R | 1 |
| Geijer, T | 1 |
| Gordon, EA | 2 |
| Kohout, TA | 1 |
| Ghahary, A | 1 |
| Cheng, KW | 1 |
| Krstenansky, JL | 1 |
| Higashida, H | 1 |
| Sano, M | 1 |
| Kato, K | 1 |
| Gilman, AG | 3 |
| Nirenberg, M | 1 |
| Minna, JD | 1 |
| Blume, AJ | 1 |
| Dalton, C | 1 |
| Sheppard, H | 1 |
1 review available for isoproterenol and Neuroblastoma
| Article | Year |
|---|---|
Agonist regulation of cellular levels of the stimulatory guanine nucleotide-binding protein, Gs, in wild type and transfected neuroblastoma-glioma hybrid NG108-15 cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Down-Regulation; Glioma; GTP-Binding Proteins | 1993 |
32 other studies available for isoproterenol and Neuroblastoma
| Article | Year |
|---|---|
Pertussis toxin-insensitive activation of the heterotrimeric G-proteins Gi/Go by the NG108-15 G-protein activator.
Topics: Animals; Brain; Carrier Proteins; Cattle; Cell Line; Cell Membrane; Colforsin; Glioma; GTP-Binding P | 2002 |
Association of DSC1, a gene modulated by adrenergic stimulation, with Alzheimer's disease.
Topics: Adrenergic beta-Agonists; Aged; Aged, 80 and over; Alzheimer Disease; Cell Line, Tumor; Desmocollins | 2006 |
Dopaminergic and adrenergic toxicities on SK-N-MC human neuroblastoma cells are mediated through G protein signaling and oxidative stress.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic beta-Agonists; Apoptosis; Cas | 2007 |
Neuroblastoma membranes inhibit isoproterenol-stimulated rise of cAMP in glioma cells.
Topics: Animals; Cell Fractionation; Cell Membrane; Cells, Cultured; Cyclic AMP; Glioma; Isoproterenol; Neur | 1984 |
Expression of the human beta 2-adrenoceptor in NCB20 cells results in agonist activation of adenylyl cyclase and agonist-mediated selective down-regulation of Gs alpha.
Topics: Adenylyl Cyclases; Animals; Base Sequence; Cricetinae; Cricetulus; Down-Regulation; Enzyme Activatio | 1995 |
Expression of functional delta opioid receptors in Xenopus oocytes.
Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4 | 1993 |
Salmeterol, a long-acting beta 2-adrenoceptor agonist mediating cyclic AMP accumulation in a neuronal cell line.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Central Nervous System Neoplasms; Cyclic AMP; Isoprote | 1993 |
Modulation of adenylylcyclase by protein kinase C in human neurotumor SK-N-MC cells: evidence that the alpha isozyme mediates both potentiation and desensitization.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Alkaloids; Aluminum Compounds; Animals; Brain; Cell | 1994 |
Receptor availability defines the extent of agonist-mediated G-protein down-regulation in neuroblastoma x glioma hybrid cells transfected to express the beta 2-adrenoceptor.
Topics: Adenylyl Cyclases; Adrenergic beta-2 Receptor Antagonists; Alprenolol; Down-Regulation; Gene Express | 1994 |
Agonist regulation of adenylate cyclase activity in neuroblastoma x glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the beta 2-adrenoceptor. Evidence that adenylate cyclase is the limiting component for receptor-mediat
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Amino Acid Sequence; Base Sequence; DNA Primers; DNA, C | 1996 |
Stimulation of phospholipase C activity by norepinephrine, t-ACPD and bombesin in LA-N-2 cells.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alanine; Bombesin; Cycloleucine; Excitatory A | 1996 |
Mechanism of ET(A)-receptor stimulation-induced increases in intracellular Ca2+ in SK-N-MC cells.
Topics: Adrenergic beta-Agonists; Calcium; Cells, Cultured; Cyclic AMP; Drug Interactions; Endothelin Recept | 1998 |
Adaptation of cAMP signaling system in SH-SY5Y neuroblastoma cells following expression of a constitutively active stimulatory G protein alpha, Q227L Gsalpha.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Chromogranins; Cyclic AMP; Cyclic AMP-Depend | 2001 |
Regulation of nerve growth factor content in a neuroblastoma cell line.
Topics: Adenosine; Animals; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Isoproterenol; Mice; Ne | 1978 |
Measurements of adenosine 3':5'-cyclic monophosphate and membrane potential in neuroblastoma times glioma hybrid cells: opiates and adrenergic agonists cause effects opposite to those of prostaglandin E1.
Topics: Animals; Cell Line; Clone Cells; Cyclic AMP; Dopamine; Glioma; Haloperidol; Hybrid Cells; Isoprotere | 1975 |
Cyclic AMP-mediated induction of ornithine decarboxylase of glioma and neuroblastoma cells.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Bucladesine; Carboxy-Lyases; Cell Line; Cyclic AMP; | 1975 |
Neuroblastoma cell adenylate cyclase: direct activation by adenosine and prostaglandins.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adenosine; Adenylyl Cyclases; Cell Line; Cyclic GMP; D | 1976 |
Dissociation of the regulation of fatty acid synthesis and cyclic AMP levels in cultured glial and neuronal cells.
Topics: Blood; Bucladesine; Cells, Cultured; Culture Media; Cyclic AMP; Fatty Acids; Isoproterenol; Neurobla | 1978 |
Phloretin and related compounds inhibit agonist stimulated cAMP accumulation in cultured cells of CNS origin.
Topics: Adenosine; Animals; Astrocytoma; Cells, Cultured; Central Nervous System; Cyclic AMP; Glycosides; Hu | 1979 |
Induction of S-adenosyl-L-methionine decarboxylase in glioma and neuroblastoma cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Line; Culture Media; Enzyme Inductio | 1977 |
Calcium fluxes in cultured and bulk isolated neuronal and glial cells.
Topics: Acetylcholine; Animals; Astrocytes; Brain Neoplasms; Calcium; Cells, Cultured; Choline; Glioma; Huma | 1977 |
Coexisting beta 1- and atypical beta-adrenergic receptors cause redundant increases in cyclic AMP in human neuroblastoma cells.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Cyclic AMP; Ethanolamines; Humans; Imidazoles | 1992 |
Identification and characterization of functional D1 dopamine receptors in a human neuroblastoma cell line.
Topics: Adenylyl Cyclases; Affinity Labels; Animals; Benzazepines; Binding, Competitive; Cyclic AMP; Dopamin | 1990 |
Procholecystokinin and proenkephalin A mRNA expression is modulated by cyclic AMP and noradrenaline.
Topics: Bucladesine; Cholecystokinin; Cyclic AMP; Enkephalins; Gene Expression; Humans; Isoproterenol; Neuro | 1990 |
Characterization of functional neuropeptide Y receptors in a human neuroblastoma cell line.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclase | 1990 |
Identification and characterization of the beta-adrenergic receptor on neuroblastoma x glioma hybrid NG108-15 cells.
Topics: Alprenolol; Bucladesine; Catecholamines; Cell Differentiation; Dihydroalprenolol; Glioma; Hybrid Cel | 1990 |
Centrally truncated neuropeptide Y analog acts as an agonist for Y1 receptors on SK-N-MC cells.
Topics: Animals; Binding, Competitive; Cats; Cyclic AMP; Humans; Isoproterenol; Neuroblastoma; Neuropeptide | 1990 |
Forskolin induction of S-100 protein in glioma and hybrid cells.
Topics: Adenylyl Cyclases; Alprostadil; Animals; Cell Line; Colforsin; Cycloheximide; Dactinomycin; Diterpen | 1985 |
Regulation of adenosine 3',5'-cyclic monophosphate metabolism in cultured neuroblastoma cells.
Topics: Carbachol; Cell Division; Cells, Cultured; Clone Cells; Culture Media; Cyclic AMP; Dopamine; Histami | 1971 |
Regulation of cyclic AMP metabolism in cultured cells of the nervous system.
Topics: Adenosine; Aminobutyrates; Animals; Brain; Carbachol; Catecholamines; Cell Division; Cells, Cultured | 1972 |
Expression of genes for metabolism of cyclic adenosine 3':5'-monophosphate in somatic cells. I. Responses to catecholamines in parental and hybrid cells.
Topics: Adenocarcinoma; Animals; Cell Line; Chromosomes; Clone Cells; Cyclic AMP; Electrophoresis, Starch Ge | 1973 |
Adenosine-mediated elevation of cyclic 3':5'-adenosine monophosphate concentrations in cultured mouse neuroblastoma cells.
Topics: Acetylcholine; Adenine; Adenosine; Animals; Benzyl Compounds; Clone Cells; Cyclic AMP; Ethers; Guani | 1973 |