isoproterenol has been researched along with Myocardial Ischemia in 204 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Isoproterenol (ISP)-induced myocardial ischemia is a classical model to screen the cardioprotective effects of various pharmacological interventions." | 8.98 | Isoproterenol-induced cardiac ischemia and fibrosis: Plant-based approaches for intervention. ( Allawadhi, P; Godugu, C; Khurana, A; Kumari, P; Sayed, N, 2018) |
| " Subsequently, a rat myocardial ischemia (MI) was established using male Sprague-Dawley (SD) rats (250 ± 20 g) subcutaneously injected with 85 mg/kg isoproterenol (ISO) for two consecutive days." | 8.31 | PLGA nanoparticles enhanced cardio-protection of scutellarin and paeoniflorin against isoproterenol-induced myocardial ischemia in rats. ( Fang, S; Jing, J; Li, L; Li, R; Liu, W; Lu, Y; Wang, C; Yang, C; Yang, S, 2023) |
| "8%) alleviated myocardial fibrosis when compared with the isoproterenol group (10." | 8.02 | Ginsenoside Rg2 alleviates myocardial fibrosis by regulating TGF-β1/Smad signalling pathway. ( Fu, W; Sui, D; Wang, Q; Wang, Y; Xu, H; Yu, X, 2021) |
| "The present study is to investigate the absorption characteristics of the main components in Polygonum orientale extract in normal and isoproterenol-induced myocardial ischemia model rats with everted intestinal sac models." | 8.02 | [Intestinal absorption characteristics of Polygonum orientale extract in normal and isoproterenol-induced myocardial ischemia model rats via everted intestinal sac models]. ( Li, N; Li, YJ; Liu, CH; Lu, Y; Pan, J; Sun, J; Wang, MJ; Wang, YL; Yang, ST, 2021) |
| " The present study was set up to investigate the cardioprotective effect of OJP1 on isoproterenol (ISO)-induced myocardial ischemia injury in rats." | 7.96 | Cardioprotective effect of the polysaccharide from Ophiopogon japonicus on isoproterenol-induced myocardial ischemia in rats. ( Chen, X; Fan, S; Liu, P; Xiao, Q; Yao, E; Zhang, J; Zhang, Y, 2020) |
| "Puerarin has shown unique pharmacological effects on myocardial ischemia (MI)." | 7.96 | The cardioprotective effects of the new crystal form of puerarin in isoproterenol-induced myocardial ischemia rats based on metabolomics. ( Du, G; Gao, Z; Li, M; Lv, Y; Qin, X; Shi, Y; Song, J; Zhou, Y, 2020) |
| "We investigated the protective effect of tetramethylpyrazine (TMP) on injury related to acute myocardial ischemia (AMI) induced by isoproterenol (ISO)." | 7.91 | Tetramethylpyrazine exerts a protective effect against injury from acute myocardial ischemia by regulating the PI3K/Akt/GSK-3β signaling pathway. ( Chen, B; Huang, DD; Huang, HH; Li, DG; Yang, Q; Yuan, CL; Zhang, LM, 2019) |
| " This study was focused on examining the effects and possible mechanisms of DHHP in rats with acute myocardial ischemia induced by isoproterenol (ISO)." | 7.91 | Investigating the effects and possible mechanisms of danshen- honghua herb pair on acute myocardial ischemia induced by isoproterenol in rats. ( Bai, JQ; Gao, S; Quan, LN; Wang, F; Wang, J; Wang, PF; Wang, XP; Wang, XT; Wang, YH; Xie, YD, 2019) |
| " Here, we investigated the effect of CaMKII inhibition in isoproterenol (ISO)-induced arrhythmias in hypertrophic mice." | 7.85 | CaMKII inhibition reduces isoproterenol-induced ischemia and arrhythmias in hypertrophic mice. ( Cheng, J; Feng, Y; Wang, Y; Wei, B, 2017) |
| " aromatica hydroalcoholic extracts on isoproterenol (ISO)-induced acute myocardial ischemia (AMI) in rats." | 7.83 | Concordance between cardio-protective effect on isoproterenol-induced acute myocardial ischemia and phenolic content of different extracts of Curcuma aromatica. ( Feng, J; Li, Y; Liu, H; Mo, Y; Yang, B, 2016) |
| "To investigate the effect of acupuncture at Neiguan (PC 6) on cardiac function using echocardiography in rat models of myocardial ischemia (MI) induced by isoproterenol (ISO)." | 7.81 | Effect of acupuncture at Neiguan (PC 6) on cardiac function using echocardiography in myocardial ischemia rats induced by isoproterenol. ( Chen, W; Chen, Y; Fan, X; Gu, Z; Hou, P; Jia, L; Liang, F; Liu, X; Ma, T; Ren, L; Rong, P; Wang, S, 2015) |
| "We have previously shown that pentoxifylline (PTX) protects from vascular complications associated with insulin resistance (IR)." | 7.80 | Pentoxifylline alleviates cardiac ischemia and dysfunction following experimental angina in insulin resistance. ( Azhar, A; El-Bassossy, HM, 2014) |
| " To investigate the effects of cinnamic aldehyde (CA) and cinnamic acid (CD) isolated from Cinnamomum cassia against myocardial ischemia produced in rats by isoproterenol (ISO)." | 7.79 | Protective effects of cinnamic acid and cinnamic aldehyde on isoproterenol-induced acute myocardial ischemia in rats. ( Li, H; Song, F; Sun, J; Wang, S, 2013) |
| " The protective effects of EA were evaluated in rat models with acute myocardial ischemia induced by isoproterenol and vasopressin." | 7.76 | Protective effects of echinocystic acid isolated from Gleditsia sinensis Lam. against acute myocardial ischemia. ( Gao, X; Huang, G; Li, J; Tang, Y; Wu, J; Zhu, Z, 2010) |
| "To study the protective effect of Buyanghuanwu Decoction on myocardial ischemia induced by isoproterenol in rats." | 7.75 | [Protective effect of Buyanghuanwu Decoction on myocardial ischemia induced by isoproterenol in rats]. ( Ji, QL; Lin, R; Liu, Y; Yang, YJ; Zhang, H; Zhang, JY, 2009) |
| "We demonstrated that propranolol reduced the incidence of arrhythmias in a rat model of myocardial infarction by coronary artery occlusion." | 7.75 | MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotection. ( Dong, D; Li, B; Li, X; Lu, Y; Pan, Z; Qiao, G; Shan, H; Song, W; Xu, C; Yang, B; Zhang, B; Zhang, F; Zhang, Y, 2009) |
| "The anti-anginal drug Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, is thought to modulate the metabolism during myocardial ischemia by activating pyruvate dehydrogenase activity to promote glucose oxidation." | 7.75 | Synthesis of ranolazine metabolites and their anti-myocardial ischemia activities. ( Gong, S; Guan, T; Li, Y; Sun, H; Wu, X; Yao, Z, 2009) |
| "This study was designed to investigate the protective effect of oleanolic acid (OA) against isoproterenol-induced myocardial ischemia in rat myocardium." | 7.74 | Cardioprotective effect of oleanolic acid on isoproterenol-induced myocardial ischemia in rats. ( Pugalendi, KV; Senthil, S; Sridevi, M, 2007) |
| "The efficiency and safety of oleanolic acid (OA) and its isomer, ursolic acid (UA) in myocardial ischemia are poorly documented." | 7.74 | Isomers (oleanolic and ursolic acids) differ in their protective effect against isoproterenol-induced myocardial ischemia in rats. ( Chandramohan, G; Pugalendi, KV; Senthil, S, 2007) |
| "To investigate the protective effect of Ginsenoside Rg2 on Chemical myocardial ischemia." | 7.72 | [Effect of ginsenoside Rg2 on chemical myocardial ischemia in rats]. ( Guo, WF; Li, H; Li, LY; Tian, JM; Wang, LP; Ye, JM, 2003) |
| "Isoproterenol hydrochloride (ISO), a beta adrenergic agonist, is known to cause ischemic necrosis in rats." | 7.70 | Effect of a novel tetrapeptide derivative in a model of isoproterenol induced myocardial necrosis. ( Jayakumar, R; Jayasundar, S; Malarvannan, P; Puvanakrishnan, R; Ramesh, CV, 1998) |
| " To test this hypothesis, we used an isolated, spontaneously beating, neonatal rat cardiac myocyte preparation to examine the effects of RA, added to the perfusion solution, on the cell contraction and arrhythmias induced by isoproterenol (ISO) or lysophosphatidylcholine (LPC)." | 7.69 | Protective effects of All-trans-retinoic acid against cardiac arrhythmias induced by isoproterenol, lysophosphatidylcholine or ischemia and reperfusion. ( Kang, JX; Leaf, A, 1995) |
| "Effects of CD-832 on isoproterenol (ISO)-induced myocardial ischemia were studied in dogs with partial coronary stenosis of the left circumflex coronary artery and findings were compared with those for nifedipine or diltiazem." | 7.69 | Effects of a new calcium antagonist, CD-832, on isoproterenol-induced myocardial ischemia in dogs with partial coronary stenosis. ( Araki, H; Higuchi, S; Kishi-Tanikawa, S; Takahashi, K; Takahashi, T; Tsuchida, K, 1996) |
| " Flosequinan, milrinone, isoprenaline and forskolin given intravenously at similarly hypotensive doses have been evaluated in separate studies for their effect on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content following coronary artery ligation in the pentobarbitone anaesthetized rat." | 7.68 | Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat. ( Dickinson, K; Foster, GA; Frodsham, G; Jones, RB, 1993) |
| "Piperine pre-treatment decreased the levels of serum markers, lipid peroxidation and PCC with increased antioxidant status in the heart tissues of ISO administered rats." | 5.46 | Piperine modulates isoproterenol induced myocardial ischemia through antioxidant and anti-dyslipidemic effect in male Wistar rats. ( Chirayil, HT; Dhivya, V; Huang, CY; Padma, VV; Priya, LB; Sathiskumar, S, 2017) |
| "Treatment with aluminum chloride could cause a significant oxidative damage, including a significant increase in MDA level and decreases in glutathione-S- transferase and SOD activities in brain of the rats, the study showed that gavage with JPFP or JPBP could remarkably alleviate the toxic responses of the rats to aluminum chloride." | 5.38 | The protective effects of polyphenols from jujube peel (Ziziphus Jujube Mill) on isoproterenol-induced myocardial ischemia and aluminum-induced oxidative damage in rats. ( Cao, J; Cheng, D; Jiang, W; Zhu, C, 2012) |
| "Aspirin was more effective than L-arginine in prolonging prothrombin time." | 5.37 | Protective effect of L-arginine in experimentally induced myocardial ischemia: comparison with aspirin. ( Abdel Maksoud, SM; El-Maraghy, SA; Gad, MZ; Saleh, AI, 2011) |
| "Myocardial infarction was produced in rats with 65, 85, 120 and 200mg/kg of ISO administered subcutaneously (sc) twice at an interval of 24h." | 5.35 | Cardioprotective activity of Ginkgo biloba Phytosomes in isoproterenol-induced myocardial necrosis in rats: a biochemical and histoarchitectural evaluation. ( Naik, SR; Panda, VS, 2008) |
| " Isoproterenol (ISP)-induced myocardial ischemia is a classical model to screen the cardioprotective effects of various pharmacological interventions." | 4.98 | Isoproterenol-induced cardiac ischemia and fibrosis: Plant-based approaches for intervention. ( Allawadhi, P; Godugu, C; Khurana, A; Kumari, P; Sayed, N, 2018) |
| " Subsequently, a rat myocardial ischemia (MI) was established using male Sprague-Dawley (SD) rats (250 ± 20 g) subcutaneously injected with 85 mg/kg isoproterenol (ISO) for two consecutive days." | 4.31 | PLGA nanoparticles enhanced cardio-protection of scutellarin and paeoniflorin against isoproterenol-induced myocardial ischemia in rats. ( Fang, S; Jing, J; Li, L; Li, R; Liu, W; Lu, Y; Wang, C; Yang, C; Yang, S, 2023) |
| "The present study is to investigate the absorption characteristics of the main components in Polygonum orientale extract in normal and isoproterenol-induced myocardial ischemia model rats with everted intestinal sac models." | 4.02 | [Intestinal absorption characteristics of Polygonum orientale extract in normal and isoproterenol-induced myocardial ischemia model rats via everted intestinal sac models]. ( Li, N; Li, YJ; Liu, CH; Lu, Y; Pan, J; Sun, J; Wang, MJ; Wang, YL; Yang, ST, 2021) |
| "8%) alleviated myocardial fibrosis when compared with the isoproterenol group (10." | 4.02 | Ginsenoside Rg2 alleviates myocardial fibrosis by regulating TGF-β1/Smad signalling pathway. ( Fu, W; Sui, D; Wang, Q; Wang, Y; Xu, H; Yu, X, 2021) |
| "Puerarin has shown unique pharmacological effects on myocardial ischemia (MI)." | 3.96 | The cardioprotective effects of the new crystal form of puerarin in isoproterenol-induced myocardial ischemia rats based on metabolomics. ( Du, G; Gao, Z; Li, M; Lv, Y; Qin, X; Shi, Y; Song, J; Zhou, Y, 2020) |
| " The present study was set up to investigate the cardioprotective effect of OJP1 on isoproterenol (ISO)-induced myocardial ischemia injury in rats." | 3.96 | Cardioprotective effect of the polysaccharide from Ophiopogon japonicus on isoproterenol-induced myocardial ischemia in rats. ( Chen, X; Fan, S; Liu, P; Xiao, Q; Yao, E; Zhang, J; Zhang, Y, 2020) |
| "A rat model of myocardial ischemia was established via isoproterenol induction." | 3.91 | Compound danshen dripping pills normalize a reprogrammed metabolism of myocardial ischemia rats to interpret its time-dependent efficacy in clinic trials: a metabolomic study. ( Aa, JY; Aa, N; Cao, B; Chu, Y; Guo, JH; Ma, XH; Sun, H; Sun, RB; Wang, GJ; Yang, ZJ; Zhou, SP, 2019) |
| " This study was focused on examining the effects and possible mechanisms of DHHP in rats with acute myocardial ischemia induced by isoproterenol (ISO)." | 3.91 | Investigating the effects and possible mechanisms of danshen- honghua herb pair on acute myocardial ischemia induced by isoproterenol in rats. ( Bai, JQ; Gao, S; Quan, LN; Wang, F; Wang, J; Wang, PF; Wang, XP; Wang, XT; Wang, YH; Xie, YD, 2019) |
| "We investigated the protective effect of tetramethylpyrazine (TMP) on injury related to acute myocardial ischemia (AMI) induced by isoproterenol (ISO)." | 3.91 | Tetramethylpyrazine exerts a protective effect against injury from acute myocardial ischemia by regulating the PI3K/Akt/GSK-3β signaling pathway. ( Chen, B; Huang, DD; Huang, HH; Li, DG; Yang, Q; Yuan, CL; Zhang, LM, 2019) |
| " We further showed that inhibition of succinate release and GPR91 signaling ameliorated oxygen-glucose deprivation-induced injury in cardiomyocytes and isoproterenol-induced myocardial ischemia injury in mice." | 3.88 | Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling. ( Li, J; Li, LZ; Liu, B; Liu, K; Liu, Q; Lu, YT; Qi, LW; Yang, YL; Yin, X; Zhang, L, 2018) |
| " In this study, a simple blood microdialysis sampling system in freely-moving rats was established for simultaneous study of PK and PD of Shengmai injection (SMI) effect on inducing real-time nitric oxide (NO) release on isoproterenol (ISO) induced myocardial ischemia rats." | 3.88 | A simple blood microdialysis in freely-moving rats for pharmacokinetic-pharmacodynamic modeling study of Shengmai injection with simultaneous determination of drug concentrations and efficacy levels in dialysate. ( Ding, B; Huang, X; Jiang, N; Li, M; Liu, G; Lv, X; Ruan, YE; Shao, Q; Zhan, S, 2018) |
| "On the basis of preliminary studies and references of relevant literature about Sheng-Mai-San for myocardial ischemia, we chose three representative components (ginsenoside Rb1 (G), ruscogenin (R) and schisandrin (S)) for the optimization design studies." | 3.88 | A Strategy for Optimizing the Combination of Active Components Based on Chinese Medicinal Formula Sheng-Mai-San for Myocardial Ischemia. ( Chu, C; Fan, XX; Kou, JP; Li, F; Yu, BY; Zhang, Y, 2018) |
| " Here, we investigated the effect of CaMKII inhibition in isoproterenol (ISO)-induced arrhythmias in hypertrophic mice." | 3.85 | CaMKII inhibition reduces isoproterenol-induced ischemia and arrhythmias in hypertrophic mice. ( Cheng, J; Feng, Y; Wang, Y; Wei, B, 2017) |
| " aromatica hydroalcoholic extracts on isoproterenol (ISO)-induced acute myocardial ischemia (AMI) in rats." | 3.83 | Concordance between cardio-protective effect on isoproterenol-induced acute myocardial ischemia and phenolic content of different extracts of Curcuma aromatica. ( Feng, J; Li, Y; Liu, H; Mo, Y; Yang, B, 2016) |
| " Electrocardiograph (ECG) changes of myocardial ischemia induced by isoproterenol were taken as pharmacodynamic indices." | 3.81 | [Formula Optimization in Renshen Jianxin Capsule Based on Uniform Design and Anti-myocardial Ischemia Effect]. ( Ding, XY; Jiang, HQ; Ju, JQ; Li, S; Li, YL; Nie, L; Yang, CH; Zhang, SJ, 2015) |
| "To investigate the effect of acupuncture at Neiguan (PC 6) on cardiac function using echocardiography in rat models of myocardial ischemia (MI) induced by isoproterenol (ISO)." | 3.81 | Effect of acupuncture at Neiguan (PC 6) on cardiac function using echocardiography in myocardial ischemia rats induced by isoproterenol. ( Chen, W; Chen, Y; Fan, X; Gu, Z; Hou, P; Jia, L; Liang, F; Liu, X; Ma, T; Ren, L; Rong, P; Wang, S, 2015) |
| "Both short-term and long-term EP markedly attenuated the isoproterenol-induced myocardial ischemia with lower serum cardiac troponin levels." | 3.80 | Role of calcitonin gene-related peptide in cardioprotection of short-term and long-term exercise preconditioning. ( Pan, SS; Sun, XJ, 2014) |
| " Furthermore, Asic3(-/-) mice demonstrated a blunted response to isoproterenol-induced cardiac tachycardia and prolonged duration to recover to baseline heart rate." | 3.80 | Abnormal cardiac autonomic regulation in mice lacking ASIC3. ( Chen, CC; Chen, WN; Cheng, CF; Kuo, TB; Lin, CC, 2014) |
| "We have previously shown that pentoxifylline (PTX) protects from vascular complications associated with insulin resistance (IR)." | 3.80 | Pentoxifylline alleviates cardiac ischemia and dysfunction following experimental angina in insulin resistance. ( Azhar, A; El-Bassossy, HM, 2014) |
| "According to the results of the in vitro pharmacological experiment, the myocardial ischemia model of rats was induced through intraperitoneal injection of isoproterenol." | 3.79 | [Study on pharmaceutical screening of representative components of Salvia miltiorrhiza diterpene quinones]. ( Jia, XB; Shi, YQ; Song, J; Xiao, W; Yu, DH, 2013) |
| " To investigate the effects of cinnamic aldehyde (CA) and cinnamic acid (CD) isolated from Cinnamomum cassia against myocardial ischemia produced in rats by isoproterenol (ISO)." | 3.79 | Protective effects of cinnamic acid and cinnamic aldehyde on isoproterenol-induced acute myocardial ischemia in rats. ( Li, H; Song, F; Sun, J; Wang, S, 2013) |
| "Isoproterenol (ISO)-induced myocardial ischemia animal model has been widely applied to the study of myocardial ischemia and evaluation of drug efficacy." | 3.79 | [Evaluation of myocardial ischemia rat model based on metabonomic method of small molecule metabolites of plasma and cardiac muscle]. ( Gu, SH; Hao, HP; Ji-Ye, A; Liu, LS; Wang, GJ; Yan, B; Zha, WB; Zhang, Y, 2013) |
| "In acute experiments in rabbits the changes of the pulmonary hemodynamics following myocardial ischemia in the region of the descendent left coronary artery were studied in normotensive animals and after the infusion of histamine or isoproterenol." | 3.79 | [The pulmonary hemodynamics changes following experimental myocardial ischemia in rabbits with decreased arterial pressure]. ( Evlakhov, VI; Poiasov, IZ, 2013) |
| "Oral administration of matrine (200, 100 and 50 mg/kg) significantly attenuated isoproterenol-induced cardiac necrosis and left ventricular dysfunction." | 3.78 | Regulation of endothelial nitric oxide synthase and asymmetric dimethylarginine by matrine attenuates isoproterenol-induced acute myocardial injury in rats. ( Dai, G; Deng, N; Guo, Y; Li, X; Wang, X; Wu, Y; Xu, Q; Zheng, P, 2012) |
| " The protective effects of EA were evaluated in rat models with acute myocardial ischemia induced by isoproterenol and vasopressin." | 3.76 | Protective effects of echinocystic acid isolated from Gleditsia sinensis Lam. against acute myocardial ischemia. ( Gao, X; Huang, G; Li, J; Tang, Y; Wu, J; Zhu, Z, 2010) |
| "This study was aimed to investigate structure-function relationship of 20(S)-panaxadiol (PD) and its epimeric derivatives ((20S, 24S)-epoxy-dammarane-3β, 12β, 25-triol, PDD1 and (20S, 24R)-epoxy-dammarane-3β, 12β, 25-triol, PDD2) in myocardial ischemia injury in rats." | 3.76 | Study on the structure-function relationship of 20(S)-panaxadiol and its epimeric derivatives in myocardial injury induced by isoproterenol. ( Bi, Y; Jiang, N; Meng, Q; Wang, T; Zhang, J, 2010) |
| "To investigate the changes of apelin in plasma and myocardium of model rats and the protective mechanisms of Extracts of Ginkgo biloba leaves (EGb) on myocardial ischemia injury induced by isoproterenol." | 3.75 | [Effects of extracts of Ginkgo biloba leaves on apelin concentration and expressions in plasma and myocardium of rats with myocardial ischemia injury]. ( Huang, JL; Xiong, GZ; Ye, CL; Ye, KH, 2009) |
| "To study the protective effect of Buyanghuanwu Decoction on myocardial ischemia induced by isoproterenol in rats." | 3.75 | [Protective effect of Buyanghuanwu Decoction on myocardial ischemia induced by isoproterenol in rats]. ( Ji, QL; Lin, R; Liu, Y; Yang, YJ; Zhang, H; Zhang, JY, 2009) |
| "We demonstrated that propranolol reduced the incidence of arrhythmias in a rat model of myocardial infarction by coronary artery occlusion." | 3.75 | MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotection. ( Dong, D; Li, B; Li, X; Lu, Y; Pan, Z; Qiao, G; Shan, H; Song, W; Xu, C; Yang, B; Zhang, B; Zhang, F; Zhang, Y, 2009) |
| "The anti-anginal drug Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, is thought to modulate the metabolism during myocardial ischemia by activating pyruvate dehydrogenase activity to promote glucose oxidation." | 3.75 | Synthesis of ranolazine metabolites and their anti-myocardial ischemia activities. ( Gong, S; Guan, T; Li, Y; Sun, H; Wu, X; Yao, Z, 2009) |
| " Male SD rats were subcutaneously injected with isoproterenol (ISO) to induce myocardial ischemia." | 3.74 | The myocardial response to adrenomedullin involves increased cAMP generation as well as augmented Akt phosphorylation. ( Cao, CQ; Jin, SJ; Pan, CS; Qi, YF; Tang, CS; Wang, X; Zhang, J; Zhao, J, 2007) |
| "The efficiency and safety of oleanolic acid (OA) and its isomer, ursolic acid (UA) in myocardial ischemia are poorly documented." | 3.74 | Isomers (oleanolic and ursolic acids) differ in their protective effect against isoproterenol-induced myocardial ischemia in rats. ( Chandramohan, G; Pugalendi, KV; Senthil, S, 2007) |
| "This study was designed to investigate the protective effect of oleanolic acid (OA) against isoproterenol-induced myocardial ischemia in rat myocardium." | 3.74 | Cardioprotective effect of oleanolic acid on isoproterenol-induced myocardial ischemia in rats. ( Pugalendi, KV; Senthil, S; Sridevi, M, 2007) |
| "Isolated perfused hearts from young (3-5 months) and aging (24-25 months) rats were subjected to 60 min of 50% coronary flow reduction and 30 min of isoproterenol (Iso) stimulation starting at 30 min of ischemia." | 3.73 | Inhibition of iNOS protects the aging heart against beta-adrenergic receptor stimulation-induced cardiac dysfunction and myocardial ischemic injury. ( Gao, F; Grunwald, Z; Hu, A; Li, D; Liu, H; Ma, XL; Qu, Y; Sharifi-Azad, S; Sun, JZ; Tao, L, 2006) |
| "Myocardial ischemia and necrosis were induced in rats by isoproterenol (2 mg." | 3.72 | [Cardioprotective effect and influence on NOS expression of Montelukast sodium in rats]. ( Chen, S; Jin, G; Men, Q; Shan, J; Xu, L; Zhang, M, 2003) |
| "To investigate the protective effect of Ginsenoside Rg2 on Chemical myocardial ischemia." | 3.72 | [Effect of ginsenoside Rg2 on chemical myocardial ischemia in rats]. ( Guo, WF; Li, H; Li, LY; Tian, JM; Wang, LP; Ye, JM, 2003) |
| "Rat model of myocardial ischemia was established by subcutaneous multi-point injecting isoproterenol." | 3.72 | [Effect of wenxin capsule on myocyte apoptosis and expression of Bcl-2, Fas gene protein in rats of experimental myocardial ischemia]. ( Cao, HX; Sheng, XY; Zhang, T, 2003) |
| "Isoproterenol hydrochloride (ISO), a beta adrenergic agonist, is known to cause ischemic necrosis in rats." | 3.70 | Effect of a novel tetrapeptide derivative in a model of isoproterenol induced myocardial necrosis. ( Jayakumar, R; Jayasundar, S; Malarvannan, P; Puvanakrishnan, R; Ramesh, CV, 1998) |
| "Carvedilol, a selective alpha(1) and non-selective beta-adrenoceptor antagonist and antioxidant, has been shown to provide significant cardiac protection in animal models of myocardial ischemia." | 3.70 | Comparison of bisoprolol and carvedilol cardioprotection in a rabbit ischemia and reperfusion model. ( Chen, J; Christopher, TA; Gao, F; Gu, J; Lopez, BL; Lysko, P; Ma, XL; Ohlstein, EH; Ruffolo, RR; Yue, TL, 2000) |
| " During the tilt table test on isoproterenol, the patient developed ventricular fibrillation which was corrected immediately by cardioversion." | 3.70 | Significant complications can occur with ischemic heart disease and tilt table testing. ( Clarke, E; Gillette, P; Leman, RB, 1999) |
| "Effects of CD-832 on isoproterenol (ISO)-induced myocardial ischemia were studied in dogs with partial coronary stenosis of the left circumflex coronary artery and findings were compared with those for nifedipine or diltiazem." | 3.69 | Effects of a new calcium antagonist, CD-832, on isoproterenol-induced myocardial ischemia in dogs with partial coronary stenosis. ( Araki, H; Higuchi, S; Kishi-Tanikawa, S; Takahashi, K; Takahashi, T; Tsuchida, K, 1996) |
| " To test this hypothesis, we used an isolated, spontaneously beating, neonatal rat cardiac myocyte preparation to examine the effects of RA, added to the perfusion solution, on the cell contraction and arrhythmias induced by isoproterenol (ISO) or lysophosphatidylcholine (LPC)." | 3.69 | Protective effects of All-trans-retinoic acid against cardiac arrhythmias induced by isoproterenol, lysophosphatidylcholine or ischemia and reperfusion. ( Kang, JX; Leaf, A, 1995) |
| " This conclusion is strengthened by the observation that hypertrophic hearts from volume-overloaded rats had similar amounts of cardiac hypertrophy to the hearts from the hypertensive rats, without a change in flow, coronary vascular resistance or ischaemic sensitivity, whereas the hearts from isoproterenol-treated rats had lower ischaemic sensitivity and coronary vascular resistance." | 3.69 | Sensitivity to ischaemic ATP breakdown in different models of cardiac hypertrophy in rats. ( Harmsen, E; Leenen, FH; Ruzicka, M; Schoemaker, R; Yu, J, 1994) |
| " Flosequinan, milrinone, isoprenaline and forskolin given intravenously at similarly hypotensive doses have been evaluated in separate studies for their effect on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content following coronary artery ligation in the pentobarbitone anaesthetized rat." | 3.68 | Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat. ( Dickinson, K; Foster, GA; Frodsham, G; Jones, RB, 1993) |
| "The influence of the azacrown ether derivative benzylaza-15-crown-5 on myocardial tolerance to ischemia and on the functional state of the zone of myocardial ischemia during coronary artery occlusion was investigated in experiments on anaesthetized open-chest cats." | 3.68 | Investigation of antiischemic properties and mechanism of action of azacrown ether derivative. ( Bogomaz, SA; Gurbanov, KG; Paperno, AA, 1992) |
| "Other factors responsible for these bradyarrhythmias include altered autonomic influence, systemic hypoxia, electrolyte disturbances, acid-based disorders, and complications of various medical therapies." | 2.41 | Diagnosis and management of bradycardia and atrioventricular block associated with acute coronary ischemia. ( Brady, WJ; Harrigan, RA, 2001) |
| "Myocardial ischemia was instigated in Sprague Dawley rats of either sex (250-450g) by administration of Isoproterenol (ISO) and doxorubicin (DOX) at doses of 25mg/kg b." | 1.72 | Pharmacological evaluation of cardioprotective potential of Berberis orthobotrys Bien.ex Aitch. ( Abbas Bukhari, SN; Akram, M; Alamgeer, -; Alharbi, KS; Alotaibi, NH; Althobaiti, YS; Arshad, L; Irfan, HM; Noor, N; Ullah, A, 2022) |
| "Isoproterenol was used as a surrogate for adrenergic stimulation both in vivo and in cardiomyocytes." | 1.62 | Discrete sites of frequent premature ventricular complexes cluster within the infarct border zone and coincide with high frequency of delayed afterdepolarizations under adrenergic stimulation. ( Amoni, M; Claus, P; De Buck, S; Dries, E; Ingelaere, S; Nagaraju, C; Roderick, HL; Sipido, KR; Vandenberk, B; Vermoortele, D; Willems, R, 2021) |
| "Myocardial ischemia was induced by administering ISO (40mg/kg/d) subcutaneously for 2 days." | 1.46 | Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway. ( Chen, J; Du, M; Feng, L; Jia, X; Ke, Z; Qiu, H; Song, J; Wang, G; Wu, H; Yang, L, 2017) |
| "Piperine pre-treatment decreased the levels of serum markers, lipid peroxidation and PCC with increased antioxidant status in the heart tissues of ISO administered rats." | 1.46 | Piperine modulates isoproterenol induced myocardial ischemia through antioxidant and anti-dyslipidemic effect in male Wistar rats. ( Chirayil, HT; Dhivya, V; Huang, CY; Padma, VV; Priya, LB; Sathiskumar, S, 2017) |
| "The study of the mechanisms leading to cardiac hypertrophy is essential to better understand cardiac development and regeneration." | 1.43 | Loss of Mouse P2Y6 Nucleotide Receptor Is Associated with Physiological Macrocardia and Amplified Pathological Cardiac Hypertrophy. ( Balligand, JL; Beauloye, C; Boeynaems, JM; Clouet, S; Communi, D; Daskalopoulos, EP; Di Pietrantonio, L; Esfahani, H; Horckmans, M; Lemaire, A; Vanorlé, M, 2016) |
| "In isoproterenol-treated rats, Zn(ASA)2 treatment normalized significantly impaired left-ventricular contractility index (Emax 2." | 1.42 | Superiority of zinc complex of acetylsalicylic acid to acetylsalicylic acid in preventing postischemic myocardial dysfunction. ( Atmanli, A; Barnucz, E; Hegedűs, P; Hirschberg, K; Karck, M; Korkmaz, S; Li, S; Loganathan, S; Radovits, T; Szabó, G; Yasui, H; Yoshikawa, Y, 2015) |
| "Isoproterenol was injected subcutaneously (30 mg/kg BW, twice, at an interval of 24 hours) on the day 70 of the study, when plasma and erythrocyte Mg level in rats fed a low Mg diet were significantly decreased by 47% and 45% compared to intact animals." | 1.39 | [Correction of isoproterenol-induced myocardial injury with magnesium salts in magnesium-deficient rats]. ( Iezhitsa, IN; Kharitonova, MV; Pan'shin, NG; Smirnov, AV; Spasov, AA; Zheltova, AA, 2013) |
| "Treatment with aluminum chloride could cause a significant oxidative damage, including a significant increase in MDA level and decreases in glutathione-S- transferase and SOD activities in brain of the rats, the study showed that gavage with JPFP or JPBP could remarkably alleviate the toxic responses of the rats to aluminum chloride." | 1.38 | The protective effects of polyphenols from jujube peel (Ziziphus Jujube Mill) on isoproterenol-induced myocardial ischemia and aluminum-induced oxidative damage in rats. ( Cao, J; Cheng, D; Jiang, W; Zhu, C, 2012) |
| "To determine how lethal arrhythmias occur during ischemia, we investigated whether the increased spatial pattern of [K(+)](o), i." | 1.38 | Regional increase in extracellular potassium can be arrhythmogenic due to nonuniform muscle contraction in rat ventricular muscle. ( Boyden, PA; Hattori, T; Miura, M; Murai, N; Nagano, T; Nishio, T; Shindoh, C, 2012) |
| "Gliclazide or saline was given q12 h for 48 h to rats received isoprenaline." | 1.38 | Blockers of sulfonylureas receptor 1 subunits may lead to cardiac protection against isoprenaline-induced injury in obese rats. ( Bao, Y; Shuyuan, L; Sun, X; Yang, W; Yerong, Y, 2012) |
| "Myocardial ischemia was induced by subcutaneous injection of ISO (85 mg/kg BW) twice at an interval of 24 h, for two consecutive days." | 1.38 | Effect of ursolic acid on cardiac marker enzymes, lipid profile and macroscopic enzyme mapping assay in isoproterenol-induced myocardial ischemic rats. ( Pugalendi, KV; Radhiga, T; Rajamanickam, C; Senthil, S, 2012) |
| "Aspirin was more effective than L-arginine in prolonging prothrombin time." | 1.37 | Protective effect of L-arginine in experimentally induced myocardial ischemia: comparison with aspirin. ( Abdel Maksoud, SM; El-Maraghy, SA; Gad, MZ; Saleh, AI, 2011) |
| "Curcumin was administered orally for 15 days to all the treated groups." | 1.36 | Curcumin protects rat myocardium against isoproterenol-induced ischemic injury: attenuation of ventricular dysfunction through increased expression of Hsp27 along with strengthening antioxidant defense system. ( Arya, DS; Golechha, M; Kumari, S; Sachdeva, J; Tanwar, V, 2010) |
| "Myocardial ischemia was induced by subcutaneous injection of isoproterenol hydrochloride (85 mg/kg body weight), for two consecutive days." | 1.36 | Hesperidin, a flavanone glycoside, on lipid peroxidation and antioxidant status in experimental myocardial ischemic rats. ( Pugalendi, KV; Selvaraj, P, 2010) |
| "Myocardial infarction was produced in rats with 65, 85, 120 and 200mg/kg of ISO administered subcutaneously (sc) twice at an interval of 24h." | 1.35 | Cardioprotective activity of Ginkgo biloba Phytosomes in isoproterenol-induced myocardial necrosis in rats: a biochemical and histoarchitectural evaluation. ( Naik, SR; Panda, VS, 2008) |
| " In integral animal experiments: acute myocardium ischemia model rats established by subcutaneous injection of isoprenaline were used, they were administered with MDG-1 in dosage of 10, 20 and 40 mg/kg respectively, and controlled with propranolol." | 1.34 | [Protective effect of Ophiopogonis polysaccharide MDG-1 on experimental myocardial ischemic rats]. ( Feng, Y; Xu, DS; Zheng, Q, 2007) |
| " Ws on chronic administration markedly augmented antioxidants (GSH, GSHPx, SOD, CAT) while Vit E did not stimulate the synthesis of endogenous antioxidants compared to sham." | 1.32 | Cardioprotection from ischemia and reperfusion injury by Withania somnifera: a hemodynamic, biochemical and histopathological assessment. ( Arya, DS; Bansal, P; Dinda, A; Gupta, SK; Joshi, S; Mohanty, I; Saxena, A; Talwar, KK, 2004) |
| "When isoproterenol was superimposed on chemical/metabolic ischemia, the degree of sequestration became greater." | 1.32 | Ischemic preconditioning prevents ischemia-induced beta-adrenergic receptor sequestration. ( Ebina, T; Fujita, T; Ishikawa, Y; Iwatsubo, K; Minamisawa, S; Schwencke, C; Toya, Y; Umemura, S, 2003) |
| "3." | 1.29 | Antiarrhythmic effects of BN-063, a newly synthesized adenosine A1 agonist, on myocardial ischaemia in rats. ( Chern, JW; Lee, YM; Yen, MH, 1994) |
| "Regional myocardial ischemia is associated with increased levels of adenosine and norepinephrine, factors that may alter activation of the beta-adrenergic receptor (beta AR)-G protein-adenylyl cyclase pathway in the heart." | 1.29 | Regional myocardial downregulation of the inhibitory guanosine triphosphate-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model of chronic episodic myocardial ischemia. ( Hammond, HK; McKirnan, MD; Ping, P; Roth, DA, 1993) |
| " Beta-adrenergic blockade with propranolol shifted the agonist's dose-response curves for heart rate and contractility to the right; however, low doses of dobutamine exhibited a negative chronotropic effect and increased the total peripheral vascular resistance." | 1.29 | A novel catecholamine, arbutamine, for a pharmacological cardiac stress agent. ( Abou-Mohamed, G; Caldwell, RW; Myers, T; Nagarajan, R, 1996) |
| "When isoproterenol was added during ischemia, glucose uptake increased, glycogen decreased, and lactate release increased." | 1.29 | Metabolic fate of glucose in reversible low-flow ischemia of the isolated working rat heart. ( Bolukoglu, H; Carmical, SG; Chen, TM; Goodwin, GW; Guthrie, PH; Taegtmeyer, H, 1996) |
| "The incidence of arrhythmias observed upon restoration of control flow was increased by ISO when the action of endogenous adenosine was blocked with DPCPX." | 1.29 | Endogenous adenosine reduces depression of cardiac function induced by beta-adrenergic stimulation during low flow perfusion. ( Dobson, JG; Fenton, RA; Galeckas, KJ, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.49) | 18.7374 |
| 1990's | 56 (27.45) | 18.2507 |
| 2000's | 62 (30.39) | 29.6817 |
| 2010's | 70 (34.31) | 24.3611 |
| 2020's | 15 (7.35) | 2.80 |
| Authors | Studies |
|---|---|
| Noor, N | 2 |
| Alamgeer, - | 2 |
| Irfan, HM | 2 |
| Akram, M | 1 |
| Arshad, L | 2 |
| Alotaibi, NH | 2 |
| Alharbi, KS | 1 |
| Abbas Bukhari, SN | 2 |
| Althobaiti, YS | 2 |
| Ullah, A | 2 |
| Saad Alharbi, K | 1 |
| Khan, SW | 1 |
| Zhang, F | 2 |
| Duan, B | 1 |
| Zhou, Z | 1 |
| Han, L | 1 |
| Huang, P | 1 |
| Ye, Y | 1 |
| Wang, Q | 2 |
| Huang, F | 1 |
| Li, J | 5 |
| Xiong, J | 1 |
| Li, X | 6 |
| Fu, H | 1 |
| Luo, X | 2 |
| Ren, Y | 1 |
| Liu, X | 2 |
| Zheng, Q | 2 |
| Qi, W | 1 |
| Liang, F | 2 |
| Yang, C | 1 |
| Yang, S | 2 |
| Fang, S | 1 |
| Li, L | 5 |
| Jing, J | 1 |
| Liu, W | 2 |
| Wang, C | 1 |
| Li, R | 1 |
| Lu, Y | 4 |
| Aa, N | 2 |
| Guo, JH | 1 |
| Cao, B | 2 |
| Sun, RB | 1 |
| Ma, XH | 1 |
| Chu, Y | 1 |
| Zhou, SP | 1 |
| Aa, JY | 1 |
| Yang, ZJ | 1 |
| Sun, H | 3 |
| Wang, GJ | 2 |
| Wang, XP | 1 |
| Wang, PF | 1 |
| Bai, JQ | 1 |
| Gao, S | 1 |
| Wang, YH | 1 |
| Quan, LN | 1 |
| Wang, F | 1 |
| Wang, XT | 1 |
| Wang, J | 1 |
| Xie, YD | 1 |
| Tsorin, IB | 1 |
| Barchukov, VV | 1 |
| Vititnova, MB | 1 |
| Kryzhanovskii, SA | 1 |
| Seredenin, SB | 1 |
| Tu, L | 1 |
| Cheng, M | 1 |
| Sun, Y | 1 |
| Fang, Y | 1 |
| Liu, J | 2 |
| Feng, J | 2 |
| Jin, Y | 1 |
| Yang, Y | 3 |
| Ding, Z | 1 |
| Zhong, R | 1 |
| Xia, T | 1 |
| Wang, W | 2 |
| Zhao, H | 1 |
| Wang, Y | 4 |
| Shu, Z | 1 |
| Fan, S | 1 |
| Zhang, J | 7 |
| Xiao, Q | 1 |
| Liu, P | 1 |
| Zhang, Y | 8 |
| Yao, E | 1 |
| Chen, X | 2 |
| Zhang, Q | 1 |
| Sun, W | 1 |
| Han, J | 1 |
| Cheng, S | 1 |
| Yu, P | 1 |
| Shen, L | 1 |
| Fan, M | 1 |
| Tong, H | 1 |
| Zhang, H | 2 |
| Chen, J | 5 |
| Xue, Y | 2 |
| Jin, W | 1 |
| Wang, H | 1 |
| Guan, S | 1 |
| Chu, X | 1 |
| Mollenhauer, M | 1 |
| Mehrkens, D | 1 |
| Klinke, A | 1 |
| Lange, M | 1 |
| Remane, L | 1 |
| Friedrichs, K | 1 |
| Braumann, S | 1 |
| Geißen, S | 1 |
| Simsekyilmaz, S | 1 |
| Nettersheim, FS | 1 |
| Lee, S | 1 |
| Peinkofer, G | 1 |
| Geisler, AC | 1 |
| Geis, B | 1 |
| Schwoerer, AP | 1 |
| Carrier, L | 1 |
| Freeman, BA | 1 |
| Dewenter, M | 1 |
| El-Armouche, A | 1 |
| Wagner, M | 1 |
| Adam, M | 1 |
| Baldus, S | 1 |
| Rudolph, V | 1 |
| Zhou, Y | 1 |
| Li, M | 2 |
| Song, J | 3 |
| Shi, Y | 2 |
| Qin, X | 1 |
| Gao, Z | 1 |
| Lv, Y | 1 |
| Du, G | 1 |
| Fu, W | 1 |
| Yu, X | 4 |
| Xu, H | 1 |
| Sui, D | 2 |
| Liu, CH | 1 |
| Wang, MJ | 1 |
| Yang, ST | 1 |
| Li, N | 1 |
| Pan, J | 1 |
| Li, YJ | 1 |
| Wang, YL | 1 |
| Sun, J | 2 |
| Amoni, M | 1 |
| Claus, P | 1 |
| Dries, E | 1 |
| Nagaraju, C | 1 |
| De Buck, S | 1 |
| Vandenberk, B | 1 |
| Ingelaere, S | 1 |
| Vermoortele, D | 1 |
| Roderick, HL | 1 |
| Sipido, KR | 1 |
| Willems, R | 1 |
| Zhai, XW | 1 |
| Zhang, L | 4 |
| Guo, YF | 1 |
| Wang, DM | 1 |
| Li, P | 1 |
| Niu, YF | 1 |
| Feng, QL | 1 |
| Wu, BW | 1 |
| Cao, JM | 1 |
| Liu, QH | 1 |
| Ke, Z | 1 |
| Wang, G | 2 |
| Yang, L | 1 |
| Qiu, H | 1 |
| Wu, H | 1 |
| Du, M | 1 |
| Jia, X | 1 |
| Feng, L | 1 |
| Kanaporis, G | 1 |
| Treinys, R | 1 |
| Fischmeister, R | 1 |
| Jurevičius, J | 1 |
| Wei, Y | 1 |
| Meng, T | 1 |
| Sun, C | 1 |
| Devrim, AK | 1 |
| Sozmen, M | 1 |
| Devrim, T | 1 |
| Sudagidan, M | 1 |
| Cinar, M | 1 |
| Kabak, YB | 1 |
| Li, F | 1 |
| Fan, XX | 1 |
| Chu, C | 1 |
| Kou, JP | 1 |
| Yu, BY | 1 |
| Zhan, S | 1 |
| Ding, B | 1 |
| Ruan, YE | 1 |
| Huang, X | 2 |
| Liu, G | 1 |
| Lv, X | 1 |
| Jiang, N | 2 |
| Shao, Q | 1 |
| Zhao, WS | 1 |
| Li, D | 2 |
| Xu, YH | 1 |
| Li, MD | 1 |
| Kou, ZJ | 1 |
| Wang, QG | 1 |
| Chen, YG | 1 |
| Joseph, ND | 1 |
| Balea, ŞS | 1 |
| Pârvu, AE | 1 |
| Pop, N | 1 |
| Marín, FZ | 1 |
| Pârvu, M | 1 |
| Lu, YT | 1 |
| Li, LZ | 1 |
| Yang, YL | 1 |
| Yin, X | 1 |
| Liu, Q | 2 |
| Liu, K | 1 |
| Liu, B | 1 |
| Qi, LW | 1 |
| Allawadhi, P | 1 |
| Khurana, A | 1 |
| Sayed, N | 1 |
| Kumari, P | 1 |
| Godugu, C | 1 |
| Erten, M | 1 |
| Çimenci, İG | 1 |
| Kuloğlu, T | 1 |
| Kalaycı, M | 1 |
| Erten, F | 1 |
| Garg, S | 1 |
| Malhotra, RK | 1 |
| Khan, SI | 1 |
| Sarkar, S | 1 |
| Susrutha, PN | 1 |
| Singh, V | 1 |
| Goyal, S | 1 |
| Nag, TC | 1 |
| Ray, R | 1 |
| Bhatia, J | 1 |
| Arya, DS | 4 |
| Yang, Q | 1 |
| Huang, DD | 1 |
| Li, DG | 1 |
| Chen, B | 1 |
| Zhang, LM | 1 |
| Yuan, CL | 1 |
| Huang, HH | 1 |
| Lv, H | 1 |
| Yu, F | 1 |
| Sha, C | 1 |
| Huang, Y | 1 |
| Zhai, R | 1 |
| Wang, T | 2 |
| Fu, F | 1 |
| Zhao, M | 1 |
| Yu, XJ | 1 |
| Liu, LZ | 1 |
| He, X | 2 |
| Deng, J | 1 |
| Zang, WJ | 1 |
| Yan, B | 1 |
| Ji-Ye, A | 1 |
| Hao, HP | 1 |
| Liu, LS | 1 |
| Zha, WB | 1 |
| Gu, SH | 1 |
| Evlakhov, VI | 1 |
| Poiasov, IZ | 1 |
| Shi, M | 1 |
| He, W | 1 |
| Liu, Y | 3 |
| Xu, Q | 2 |
| Song, F | 1 |
| Li, H | 2 |
| Wang, S | 2 |
| Yu, DH | 1 |
| Jia, XB | 1 |
| Shi, YQ | 1 |
| Xiao, W | 1 |
| Speerschneider, T | 1 |
| Thomsen, MB | 1 |
| Sun, XJ | 1 |
| Pan, SS | 2 |
| Kharitonova, MV | 1 |
| Zheltova, AA | 1 |
| Spasov, AA | 1 |
| Smirnov, AV | 1 |
| Pan'shin, NG | 1 |
| Iezhitsa, IN | 1 |
| Cheng, CF | 2 |
| Kuo, TB | 2 |
| Chen, WN | 1 |
| Lin, CC | 2 |
| Chen, CC | 2 |
| Sahu, BD | 1 |
| Kuncha, M | 1 |
| Rachamalla, SS | 1 |
| Sistla, R | 1 |
| Azhar, A | 1 |
| El-Bassossy, HM | 2 |
| Uhl, S | 1 |
| Mathar, I | 1 |
| Vennekens, R | 1 |
| Freichel, M | 1 |
| Toldo, S | 1 |
| Mezzaroma, E | 1 |
| Bressi, E | 1 |
| Marchetti, C | 1 |
| Carbone, S | 1 |
| Sonnino, C | 1 |
| Van Tassell, BW | 1 |
| Abbate, A | 1 |
| Korkmaz, S | 1 |
| Atmanli, A | 1 |
| Li, S | 2 |
| Radovits, T | 1 |
| Hegedűs, P | 1 |
| Barnucz, E | 1 |
| Hirschberg, K | 1 |
| Loganathan, S | 1 |
| Yoshikawa, Y | 1 |
| Yasui, H | 1 |
| Karck, M | 1 |
| Szabó, G | 1 |
| Watson, ML | 1 |
| Shudong, W | 1 |
| Lide, Z | 1 |
| Baoqiang, D | 1 |
| Wenshun, Z | 1 |
| Ee, HC | 1 |
| Na, G | 1 |
| Yiguo, C | 1 |
| Tang, YN | 1 |
| He, XC | 1 |
| Ye, M | 1 |
| Huang, H | 1 |
| Chen, HL | 1 |
| Peng, WL | 1 |
| Zhao, ZZ | 1 |
| Yi, T | 1 |
| Chen, HB | 1 |
| Yang, CH | 1 |
| Li, YL | 1 |
| Jiang, HQ | 1 |
| Nie, L | 1 |
| Ju, JQ | 1 |
| Ding, XY | 1 |
| Zhang, SJ | 1 |
| Ren, L | 1 |
| Jia, L | 1 |
| Gu, Z | 1 |
| Fan, X | 1 |
| Chen, W | 2 |
| Hou, P | 1 |
| Rong, P | 1 |
| Ma, T | 1 |
| Chen, Y | 2 |
| Zhao, C | 1 |
| Meng, F | 1 |
| Geng, L | 1 |
| Zhao, X | 1 |
| Zhou, H | 1 |
| Qin, S | 1 |
| Clouet, S | 1 |
| Di Pietrantonio, L | 1 |
| Daskalopoulos, EP | 1 |
| Esfahani, H | 1 |
| Horckmans, M | 1 |
| Vanorlé, M | 1 |
| Lemaire, A | 1 |
| Balligand, JL | 2 |
| Beauloye, C | 1 |
| Boeynaems, JM | 1 |
| Communi, D | 1 |
| Li, Y | 4 |
| Mo, Y | 1 |
| Liu, H | 3 |
| Yang, B | 2 |
| Drum, BM | 1 |
| Yin, H | 1 |
| Guo, X | 1 |
| Luckey, SW | 1 |
| Gilbert, ML | 1 |
| McKnight, GS | 1 |
| Scott, JD | 1 |
| Santana, LF | 1 |
| Guo, J | 1 |
| Yong, Y | 1 |
| Aa, J | 1 |
| Sun, R | 1 |
| Huang, J | 1 |
| Yang, N | 1 |
| Yan, L | 1 |
| Cao, J | 2 |
| Yang, Z | 1 |
| Kong, X | 1 |
| Wang, L | 1 |
| Zhu, X | 1 |
| Ma, X | 1 |
| Guo, Z | 1 |
| Zhou, S | 1 |
| Dhivya, V | 1 |
| Priya, LB | 1 |
| Chirayil, HT | 1 |
| Sathiskumar, S | 1 |
| Huang, CY | 1 |
| Padma, VV | 1 |
| Feng, Y | 2 |
| Cheng, J | 1 |
| Wei, B | 1 |
| Yao, H | 1 |
| Chen, ZW | 1 |
| Panda, VS | 1 |
| Naik, SR | 1 |
| Penson, PE | 1 |
| Ford, WR | 2 |
| Kidd, EJ | 1 |
| Broadley, KJ | 1 |
| Ross, JL | 1 |
| Howlett, SE | 1 |
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| Ren, LQ | 1 |
| Yu, XY | 1 |
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| Li, XJ | 1 |
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| Zhao, J | 6 |
| Yuan, J | 1 |
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| Saleh, AI | 1 |
| Abdel Maksoud, SM | 1 |
| El-Maraghy, SA | 1 |
| Gad, MZ | 1 |
| Shen, YJ | 1 |
| Zhuang, T | 1 |
| Wang, FJ | 1 |
| Selvaraj, P | 2 |
| Pugalendi, KV | 5 |
| Chen, IL | 1 |
| Cheng, MH | 1 |
| Lian, WS | 1 |
| Gao, XL | 1 |
| Yuan, BX | 1 |
| Hu, YM | 1 |
| Fu, JF | 1 |
| Zhang, Z | 2 |
| Xu, YQ | 2 |
| Wan, LH | 1 |
| Xiong, WB | 1 |
| Zhou, LM | 1 |
| Haleagrahara, N | 1 |
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| Chakravarthi, S | 1 |
| Johnson, CM | 1 |
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| Cheng, D | 1 |
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| Miura, M | 1 |
| Hattori, T | 1 |
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| Boyden, PA | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Allopurinol in the Treatment of Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease Treated by Either PCI or CABG: Pilot Study[NCT03700645] | Phase 4 | 100 participants (Anticipated) | Interventional | 2018-12-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for isoproterenol and Myocardial Ischemia
| Article | Year |
|---|---|
Isoproterenol-induced cardiac ischemia and fibrosis: Plant-based approaches for intervention.
Topics: Alkaloids; Animals; Fibrosis; Flavonoids; Glycosides; Heart; Humans; Isoproterenol; Myocardial Infar | 2018 |
Diagnosis and management of bradycardia and atrioventricular block associated with acute coronary ischemia.
Topics: Adrenergic beta-Agonists; Aminophylline; Anti-Arrhythmia Agents; Atropine; Bradycardia; Cardiotonic | 2001 |
1 trial available for isoproterenol and Myocardial Ischemia
| Article | Year |
|---|---|
[Prevention of sudden death in myocardial infarct: do experimental results help to understand the clinical reality? The case of the clinical trial SWORD (Survival With ORal D-sotalol)].
Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Drug Therapy, Combination; Femal | 1996 |
201 other studies available for isoproterenol and Myocardial Ischemia
| Article | Year |
|---|---|
Pharmacological evaluation of cardioprotective potential of Berberis orthobotrys Bien.ex Aitch.
Topics: Animals; Berberis; Doxorubicin; Isoproterenol; Myocardial Ischemia; Plant Extracts; Rats; Rats, Spra | 2022 |
Cardioprotective potential of Thymus linearis Benth.
Topics: Animals; Aspartate Aminotransferases; Biomarkers; Female; Isoproterenol; L-Lactate Dehydrogenase; Ma | 2022 |
Integration of metabolomics and transcriptomics to reveal anti-chronic myocardial ischemia mechanism of Gualou Xiebai decoction.
Topics: Animals; Drugs, Chinese Herbal; Isoproterenol; Medicine, Chinese Traditional; Metabolomics; Myocardi | 2022 |
Study on the Specific Expression of Infrared Radiation Temperature on the Body Surface of Acupoint in Rats with Chronic Myocardial Ischemic Injury.
Topics: Acupuncture Points; Animals; Electroacupuncture; Humans; Isoproterenol; Male; Myocardial Ischemia; R | 2023 |
PLGA nanoparticles enhanced cardio-protection of scutellarin and paeoniflorin against isoproterenol-induced myocardial ischemia in rats.
Topics: Animals; Coronary Artery Disease; Isoproterenol; Male; Myocardial Ischemia; Nanoparticles; Rats; Rat | 2023 |
Compound danshen dripping pills normalize a reprogrammed metabolism of myocardial ischemia rats to interpret its time-dependent efficacy in clinic trials: a metabolomic study.
Topics: Animals; Camphanes; Cohort Studies; Disease Models, Animal; Drugs, Chinese Herbal; Female; Isoproter | 2019 |
Investigating the effects and possible mechanisms of danshen- honghua herb pair on acute myocardial ischemia induced by isoproterenol in rats.
Topics: Animals; Apoptosis; Aspartate Aminotransferases; bcl-2-Associated X Protein; Carthamus tinctorius; C | 2019 |
Anti-Ischemic Activity of Fabomotizole Hydrochloride under Conditions of Endothelial Dysfunction.
Topics: Animals; Animals, Outbred Strains; Benzimidazoles; Cardiotonic Agents; Disease Models, Animal; Endoc | 2019 |
Fabrication of ultra-small nanocrystals by formation of hydrogen bonds: In vitro and in vivo evaluation.
Topics: Animals; Biological Availability; Caco-2 Cells; Cardiovascular Agents; Diffusion; Disease Models, An | 2020 |
Cardioprotective effects of a Fructus Aurantii polysaccharide in isoproterenol-induced myocardial ischemic rats.
Topics: Adrenergic beta-Agonists; Animals; Antioxidants; Cardiotonic Agents; Citrus; Disease Models, Animal; | 2020 |
Cardioprotective effect of the polysaccharide from Ophiopogon japonicus on isoproterenol-induced myocardial ischemia in rats.
Topics: Animals; Antioxidants; Biomarkers; Ca(2+) Mg(2+)-ATPase; Cardiotonic Agents; Catalase; Electrocardio | 2020 |
The circular RNA hsa_circ_0007623 acts as a sponge of microRNA-297 and promotes cardiac repair.
Topics: Animals; Base Sequence; Cardiomyopathies; Cell Movement; Cell Proliferation; Gene Expression Regulat | 2020 |
Safranal, an active constituent of saffron, ameliorates myocardial ischemia via reduction of oxidative stress and regulation of Ca
Topics: Animals; Calcium; Cardiotonic Agents; Cells, Cultured; Crocus; Cyclohexenes; Disease Models, Animal; | 2020 |
Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Calcium-Calmodulin-Dependent Protein | 2020 |
The cardioprotective effects of the new crystal form of puerarin in isoproterenol-induced myocardial ischemia rats based on metabolomics.
Topics: Animals; Cardiotonic Agents; Crystallization; Disease Models, Animal; Heart; Humans; Isoflavones; Is | 2020 |
Ginsenoside Rg2 alleviates myocardial fibrosis by regulating TGF-β1/Smad signalling pathway.
Topics: Animals; Cardiotonic Agents; Dose-Response Relationship, Drug; Fibrosis; Ginsenosides; Isoproterenol | 2021 |
[Intestinal absorption characteristics of Polygonum orientale extract in normal and isoproterenol-induced myocardial ischemia model rats via everted intestinal sac models].
Topics: Animals; Intestinal Absorption; Intestines; Isoproterenol; Myocardial Ischemia; Polygonum; Rats; Rat | 2021 |
Discrete sites of frequent premature ventricular complexes cluster within the infarct border zone and coincide with high frequency of delayed afterdepolarizations under adrenergic stimulation.
Topics: Animals; Disease Models, Animal; Epicardial Mapping; Isoproterenol; Magnetic Resonance Imaging, Cine | 2021 |
The IK1/Kir2.1 channel agonist zacopride prevents and cures acute ischemic arrhythmias in the rat.
Topics: Action Potentials; Acute Disease; Animals; Arrhythmias, Cardiac; Benzamides; Bridged Bicyclo Compoun | 2017 |
Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway.
Topics: Animals; Apoptosis; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glycosid | 2017 |
Metabolic inhibition reduces cardiac L-type Ca2+ channel current due to acidification caused by ATP hydrolysis.
Topics: Adenosine Triphosphate; Animals; Calcium Channels, L-Type; Carbonyl Cyanide p-Trifluoromethoxyphenyl | 2017 |
Protective effect of diltiazem on myocardial ischemic rats induced by isoproterenol.
Topics: Animals; Calcium; Cardiotonic Agents; Connexin 43; Diltiazem; Disease Models, Animal; Isoproterenol; | 2018 |
Periostin normalizes levels of cardiac markers in rats with experimental isoproterenol cardiotoxicity.
Topics: Alanine Transaminase; Animals; Antioxidants; Cardiotoxicity; Catalase; Cell Adhesion Molecules; Isop | 2017 |
A Strategy for Optimizing the Combination of Active Components Based on Chinese Medicinal Formula Sheng-Mai-San for Myocardial Ischemia.
Topics: Animals; Creatine Kinase, MB Form; Cyclooctanes; Disease Models, Animal; Drug Combinations; Drugs, C | 2018 |
A simple blood microdialysis in freely-moving rats for pharmacokinetic-pharmacodynamic modeling study of Shengmai injection with simultaneous determination of drug concentrations and efficacy levels in dialysate.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Dialysis Solutions; Disease Models, Anima | 2018 |
The Beneficial Effects of Electroacupuncture at PC6 Acupoints (Neiguan) on Myocardial Ischemia in ASIC3 -/- mice.
Topics: Acid Sensing Ion Channels; Acupuncture Points; Adrenergic beta-Agonists; Animals; Electroacupuncture | 2018 |
Polyphenolic Compounds, Antioxidant, and Cardioprotective Effects of Pomace Extracts from Fetească Neagră Cultivar.
Topics: Animals; Anthocyanins; Antioxidants; Cardiotonic Agents; Chromatography, High Pressure Liquid; Flavo | 2018 |
Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Apoptosis; Dynamins; Enzyme Activation; Extracellula | 2018 |
The relationship between visfatin and cardiac markers on induced myocardial infarction in rats.
Topics: Animals; Biomarkers; Disease Models, Animal; Female; Heart; Isoproterenol; Myocardial Infarction; My | 2019 |
Fisetin attenuates isoproterenol-induced cardiac ischemic injury in vivo by suppressing RAGE/NF-κB mediated oxidative stress, apoptosis and inflammation.
Topics: Animals; Antioxidants; Apoptosis; Flavonoids; Flavonols; Heart; Isoproterenol; Male; Myocardial Isch | 2019 |
Tetramethylpyrazine exerts a protective effect against injury from acute myocardial ischemia by regulating the PI3K/Akt/GSK-3β signaling pathway.
Topics: Animals; Cytokines; Glycogen Synthase Kinase 3 beta; Inflammation; Isoproterenol; Male; Myocardial I | 2019 |
Effects of rotigotine and rotigotine extended-release microsphere therapy on myocardial ischemic injury in mice.
Topics: Animals; Cardiotonic Agents; Chlorpromazine; Creatine Kinase, MB Form; Dopamine Agonists; Isoprotere | 2019 |
Pyridostigmine regulates glucose metabolism and mitochondrial homeostasis to reduce myocardial vulnerability to injury in diabetic mice.
Topics: Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Glucos | 2019 |
[Evaluation of myocardial ischemia rat model based on metabonomic method of small molecule metabolites of plasma and cardiac muscle].
Topics: Animals; Creatine Kinase; Energy Metabolism; Isoproterenol; Lipid Metabolism; Male; Metabolome; Meta | 2013 |
[The pulmonary hemodynamics changes following experimental myocardial ischemia in rabbits with decreased arterial pressure].
Topics: Animals; Arterial Pressure; Blood Pressure; Coronary Circulation; Coronary Vessels; Hemodynamics; Hi | 2013 |
Protective effect of total phenylethanoid glycosides from Monochasma savatieri Franch on myocardial ischemia injury.
Topics: Animals; Cardiotonic Agents; Cell Survival; Glycosides; Heart; Humans; Hydrogen Peroxide; Isoprotere | 2013 |
Protective effects of cinnamic acid and cinnamic aldehyde on isoproterenol-induced acute myocardial ischemia in rats.
Topics: Acrolein; Animals; Cardiotonic Agents; Cinnamates; Creatine Kinase, MB Form; Interleukin-6; Isoprote | 2013 |
[Study on pharmaceutical screening of representative components of Salvia miltiorrhiza diterpene quinones].
Topics: Animals; Diterpenes; Drug Evaluation, Preclinical; Isoproterenol; Male; Myocardial Ischemia; Quinone | 2013 |
Physiology and analysis of the electrocardiographic T wave in mice.
Topics: Adrenergic beta-Agonists; Animals; Calcium Channel Blockers; Chronic Disease; Disease Models, Animal | 2013 |
Role of calcitonin gene-related peptide in cardioprotection of short-term and long-term exercise preconditioning.
Topics: Animals; Calcitonin Gene-Related Peptide; Ischemic Preconditioning, Myocardial; Isoproterenol; Male; | 2014 |
[Correction of isoproterenol-induced myocardial injury with magnesium salts in magnesium-deficient rats].
Topics: Animals; Aspartic Acid; Diet; Disease Models, Animal; Isoproterenol; Magnesium; Magnesium Chloride; | 2013 |
Abnormal cardiac autonomic regulation in mice lacking ASIC3.
Topics: Acid Sensing Ion Channels; Animals; Blood Pressure; Heart Rate; Humans; Isoproterenol; Mice; Mice, T | 2014 |
Lagerstroemia speciosa L. attenuates apoptosis in isoproterenol-induced cardiotoxic mice by inhibiting oxidative stress: possible role of Nrf2/HO-1.
Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Biomarkers; Blotting, Western; Heme Oxygenase-1; Isopr | 2015 |
Pentoxifylline alleviates cardiac ischemia and dysfunction following experimental angina in insulin resistance.
Topics: Adiponectin; Administration, Oral; Angina Pectoris; Animals; Diet; Disease Models, Animal; Electroca | 2014 |
Adenylyl cyclase-mediated effects contribute to increased Isoprenaline-induced cardiac contractility in TRPM4-deficient mice.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Calcium; Cardiotonic Agents; Colforsin; Cyclic A | 2014 |
Interleukin-1β blockade improves left ventricular systolic/diastolic function and restores contractility reserve in severe ischemic cardiomyopathy in the mouse.
Topics: Animals; Antibodies, Monoclonal; Disease Models, Animal; Echocardiography; Interleukin-1beta; Isopro | 2014 |
Superiority of zinc complex of acetylsalicylic acid to acetylsalicylic acid in preventing postischemic myocardial dysfunction.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Coordination Complexes; Electrocardiograp | 2015 |
Xanthine oxidase inhibition alleviates the cardiac complications of insulin resistance: effect on low grade inflammation and the angiotensin system.
Topics: Administration, Oral; Allopurinol; Angiotensin II; Animals; Diet, High-Fat; Electrocardiography; Enz | 2015 |
Protein and RNA expression of acid-sensing ion channels 2 and 3 in myocardial ischemia rats induced by isoproterenol.
Topics: Acid Sensing Ion Channels; Acupuncture Points; Animals; Electroacupuncture; Humans; Isoproterenol; M | 2015 |
Cardioprotective effect of total saponins from three medicinal species of Dioscorea against isoprenaline-induced myocardial ischemia.
Topics: Animals; Aspartate Aminotransferases; Cardiotonic Agents; Catalase; Creatine Kinase; Dioscorea; Glut | 2015 |
[Formula Optimization in Renshen Jianxin Capsule Based on Uniform Design and Anti-myocardial Ischemia Effect].
Topics: Astragalus propinquus; Chemistry, Pharmaceutical; Coronary Artery Disease; Drugs, Chinese Herbal; El | 2015 |
Effect of acupuncture at Neiguan (PC 6) on cardiac function using echocardiography in myocardial ischemia rats induced by isoproterenol.
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Echocardiography; Heart; Humans; Isoproterenol; Ma | 2015 |
Cardiac-protective effects and the possible mechanisms of alatamine during acute myocardial ischemia.
Topics: Animals; Apoptosis; Caspase 3; Creatine Kinase, MB Form; Emodin; Heart Ventricles; Isoproterenol; Ma | 2016 |
Loss of Mouse P2Y6 Nucleotide Receptor Is Associated with Physiological Macrocardia and Amplified Pathological Cardiac Hypertrophy.
Topics: Animals; Cardiomegaly; Hyperplasia; Isoproterenol; Male; Mice; Mice, Knockout; Myocardial Ischemia; | 2016 |
Concordance between cardio-protective effect on isoproterenol-induced acute myocardial ischemia and phenolic content of different extracts of Curcuma aromatica.
Topics: Animals; Cardiotonic Agents; Curcuma; Isoproterenol; Male; Myocardial Ischemia; Phenols; Plant Extra | 2016 |
Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve.
Topics: A Kinase Anchor Proteins; Animals; Calcineurin; Calcium Signaling; Calcium-Binding Proteins; Cardiom | 2017 |
Compound danshen dripping pills modulate the perturbed energy metabolism in a rat model of acute myocardial ischemia.
Topics: Animals; Camphanes; Disease Models, Animal; Drugs, Chinese Herbal; Energy Metabolism; Fatty Acids; G | 2016 |
Piperine modulates isoproterenol induced myocardial ischemia through antioxidant and anti-dyslipidemic effect in male Wistar rats.
Topics: Alkaloids; Animals; Antioxidants; Benzodioxoles; Biomarkers; Heart; Isoproterenol; Lipid Peroxidatio | 2017 |
CaMKII inhibition reduces isoproterenol-induced ischemia and arrhythmias in hypertrophic mice.
Topics: Animals; Arrhythmias, Cardiac; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; Car | 2017 |
[Protective effect of urantide against myocardial ischemia injury].
Topics: Animals; Calcium; Cardiotonic Agents; Cells, Cultured; Electrocardiography; Female; Isoproterenol; L | 2008 |
Cardioprotective activity of Ginkgo biloba Phytosomes in isoproterenol-induced myocardial necrosis in rats: a biochemical and histoarchitectural evaluation.
Topics: Adrenergic beta-Agonists; Animals; Ginkgo biloba; Heart; Isoproterenol; Myocardial Infarction; Myoca | 2008 |
Activation of beta-adrenoceptors mimics preconditioning of rat-isolated atria and ventricles against ischaemic contractile dysfunction.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atrial Function; Heart Atria; Ischem | 2008 |
Beta-adrenoceptor stimulation exacerbates detrimental effects of ischemia and reperfusion in isolated guinea pig ventricular myocytes.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Cell Survival; Guinea Pigs; Heart Ventricles; Homeostasi | 2009 |
[Expression and implication of angiotensin II type 1 receptor in myocardial fibrosis of rats].
Topics: Animals; Aspartate Aminotransferases; Cardiomyopathies; Cell Differentiation; Creatine Kinase; Fibro | 2008 |
[Fenofibrate improves energy metabolism and attenuates isoproterenol induced acute myocardial ischemic injury in rats via PPAR alpha activation].
Topics: Animals; Disease Models, Animal; Energy Metabolism; Fenofibrate; Isoproterenol; Male; Myocardial Isc | 2008 |
Efficacy of grape seed proanthocyanidins on cardioprotection during isoproterenol-induced myocardial injury in rats.
Topics: Administration, Oral; Animals; Antioxidants; Biomarkers; Blood Chemical Analysis; Cardiotonic Agents | 2009 |
Myocardial electrical activity does not affect myocardial electrical impedance measurements.
Topics: Animals; Coronary Circulation; Coronary Vessels; Dogs; Electric Impedance; Electrochemistry; Electro | 2009 |
[Protective effect of Buyanghuanwu Decoction on myocardial ischemia induced by isoproterenol in rats].
Topics: Animals; Aspartate Aminotransferases; Cardiotonic Agents; CD40 Antigens; CD40 Ligand; Creatine Kinas | 2009 |
Protective effects of echinocystic acid isolated from Gleditsia sinensis Lam. against acute myocardial ischemia.
Topics: Adrenergic beta-Agonists; Animals; Drug Evaluation, Preclinical; Female; Gleditsia; Isoproterenol; M | 2010 |
MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotection.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Cyclic AMP-Dep | 2009 |
[Effects of Ginkgo biloba extract (EGB) on acute myocardial ischemia induced by isoproterenol in rats].
Topics: Animals; Drugs, Chinese Herbal; Ginkgo biloba; Hemodynamics; Isoproterenol; Male; Myocardial Ischemi | 2009 |
Connective tissue growth factor overexpression in cardiomyocytes promotes cardiac hypertrophy and protection against pressure overload.
Topics: Angiotensin II; Animals; Base Sequence; Calcium; Cardiomegaly; Connective Tissue Growth Factor; DNA | 2009 |
Synthesis of ranolazine metabolites and their anti-myocardial ischemia activities.
Topics: Acetanilides; Animals; Cardiovascular Agents; Drug Evaluation, Preclinical; Electrocardiography; Fem | 2009 |
[Effects of extracts of Ginkgo biloba leaves on apelin concentration and expressions in plasma and myocardium of rats with myocardial ischemia injury].
Topics: Animals; Apelin; Cardiotonic Agents; Carrier Proteins; Disease Models, Animal; Female; Ginkgo biloba | 2009 |
Curcumin protects rat myocardium against isoproterenol-induced ischemic injury: attenuation of ventricular dysfunction through increased expression of Hsp27 along with strengthening antioxidant defense system.
Topics: Animals; Antioxidants; Blood Pressure; Catalase; Creatine Kinase, MB Form; Curcumin; Glutathione; He | 2010 |
Study on the structure-function relationship of 20(S)-panaxadiol and its epimeric derivatives in myocardial injury induced by isoproterenol.
Topics: Animals; Antioxidants; Creatine Kinase; Ginsenosides; Glutathione Peroxidase; Isomerism; Isoproteren | 2010 |
[Protective effect of total flavonoid of Herba Pyrolae on acute myocardial ischemic injury induced by isoproterenol in rats].
Topics: Acute Disease; Animals; Antioxidants; Cardiotonic Agents; Dose-Response Relationship, Drug; Drugs, C | 2010 |
Ghrelin improves disturbed myocardial energy metabolism in rats with heart failure induced by isoproterenol.
Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Eating; Echocardiography; Energy Metabolism; | 2010 |
Ramipril-like activity of Spondias mombin linn against no-flow ischemia and isoproterenol-induced cardiotoxicity in rat heart.
Topics: Anacardiaceae; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiovascular Agents; Catalase; C | 2010 |
Protective effect of L-arginine in experimentally induced myocardial ischemia: comparison with aspirin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Arginine; Aspirin; Cardiotonic Agents; Chol | 2011 |
Exercise preconditioning initiates late cardioprotection against isoproterenol-induced myocardial injury in rats independent of protein kinase C.
Topics: Animals; Benzophenanthridines; Isoproterenol; Male; Microscopy, Electron, Transmission; Myocardial I | 2011 |
Hesperidin, a flavanone glycoside, on lipid peroxidation and antioxidant status in experimental myocardial ischemic rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Cardiotonic Agents; Catala | 2010 |
Efficacy of hesperidin on plasma, heart and liver tissue lipids in rats subjected to isoproterenol-induced cardiotoxicity.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Heart; Hesperidin; Isoproterenol; Lipid Metabol | 2012 |
Acid-sensing ion channel 3, but not capsaicin receptor TRPV1, plays a protective role in isoproterenol-induced myocardial ischemia in mice.
Topics: Acid Sensing Ion Channels; Animals; Disease Models, Animal; Electrocardiography, Ambulatory; Fibrosi | 2011 |
[The effects and mechanisms of total flaveos Gymostemma pentaphyllum (Thunb) mak against rat myocardial ischemia].
Topics: Animals; Cycadopsida; Down-Regulation; Female; Flavones; Isoproterenol; Male; Myocardial Ischemia; p | 2008 |
[The effect of LPC on the pacemaker current I(f) in ischemic myocardium and the influence of ISO on it].
Topics: Animals; Isoproterenol; Lysophosphatidylcholines; Membrane Potentials; Microelectrodes; Myocardial I | 2004 |
Protective effects of Carthamus tinctorius injection on isoprenaline-induced myocardial injury in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cardiovascular Agents; Carthamus tinctorius; Disease | 2011 |
Cardioprotective effects of glycyrrhizic acid against isoproterenol-induced myocardial ischemia in rats.
Topics: Animals; Body Weight; Cardiotonic Agents; Dinoprost; Glutathione; Glycyrrhizic Acid; Isoproterenol; | 2011 |
Focal initiation of sustained and nonsustained ventricular tachycardia in a canine model of ischemic cardiomyopathy.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Cardiac Pacing, Artificial; Cardiomyopathies; | 2012 |
The protective effects of polyphenols from jujube peel (Ziziphus Jujube Mill) on isoproterenol-induced myocardial ischemia and aluminum-induced oxidative damage in rats.
Topics: Adenosine Triphosphatases; Aluminum Chloride; Aluminum Compounds; Animals; Chlorides; Creatine Kinas | 2012 |
Regional increase in extracellular potassium can be arrhythmogenic due to nonuniform muscle contraction in rat ventricular muscle.
Topics: Animals; Arrhythmias, Cardiac; Calcium; Cardiotonic Agents; Excitation Contraction Coupling; Heart V | 2012 |
Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats.
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Cardiotonic Agents; Creatine Kinase; Disease Mod | 2012 |
Evaluation of antioxidant and immunity activities of quercetin in isoproterenol-treated rats.
Topics: Animals; Antioxidants; Ca(2+) Mg(2+)-ATPase; Creatine Kinase, MB Form; Cytokines; Electrocardiograph | 2012 |
Combination of opium smoking and hypercholesterolemia augments susceptibility for lethal cardiac arrhythmia and atherogenesis in rabbit.
Topics: Animals; Arrhythmias, Cardiac; Atherosclerosis; Hypercholesterolemia; Isoproterenol; Myocardial Isch | 2012 |
The plating of rat scar myofibroblasts on matrigel unmasks a novel phenotype; the self assembly of lumen-like structures.
Topics: Actins; Animals; Carbocyanines; Cell Culture Techniques; Cell Differentiation; Cell Separation; Cell | 2012 |
Effect of ginsenoside Rh1 on myocardial injury and heart function in isoproterenol-induced cardiotoxicity in rats.
Topics: Animals; Blood Pressure; Cardiotonic Agents; Creatine Kinase; Disease Models, Animal; Ginsenosides; | 2012 |
Blockers of sulfonylureas receptor 1 subunits may lead to cardiac protection against isoprenaline-induced injury in obese rats.
Topics: Animals; ATP-Binding Cassette Transporters; Cell Size; Gene Expression Regulation; Gliclazide; Heart | 2012 |
Regulation of endothelial nitric oxide synthase and asymmetric dimethylarginine by matrine attenuates isoproterenol-induced acute myocardial injury in rats.
Topics: Alkaloids; Amidohydrolases; Animals; Arginine; Catechol O-Methyltransferase; Glycogen Synthase Kinas | 2012 |
Effect of ursolic acid on cardiac marker enzymes, lipid profile and macroscopic enzyme mapping assay in isoproterenol-induced myocardial ischemic rats.
Topics: Animals; Biomarkers; Cardiotonic Agents; Cholesterol; Cholesterol, LDL; Cholesterol, VLDL; Creatine | 2012 |
Melatonin protects against isoproterenol-induced alterations in cardiac mitochondrial energy-metabolizing enzymes, apoptotic proteins, and assists in complete recovery from myocardial injury in rats.
Topics: Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Glutathione; Isoenzymes; Isoprotereno | 2012 |
Ca(2+) loading and adrenergic stimulation reveal male/female differences in susceptibility to ischemia-reperfusion injury.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Disease Susceptibility; Dose-Response Relationship, Drug | 2002 |
[Ischemic pseudo-normalization of T waves and ST segment].
Topics: Acute Disease; Bias; Cardiotonic Agents; Diagnostic Errors; Electrocardiography; Exercise Test; Hear | 1999 |
Changes of adrenomedullin and receptor activity modifying protein 2 (RAMP2) in myocardium and aorta in rats with isoproterenol-induced myocardial ischemia.
Topics: Adrenomedullin; Animals; Aorta; Disease Models, Animal; Heart; Intracellular Signaling Peptides and | 2003 |
Ischemic preconditioning prevents ischemia-induced beta-adrenergic receptor sequestration.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Cell Line; Cell Survival; Colforsin; Deoxyglucose; Huma | 2003 |
Phospholamban phosphorylation in ischemia-reperfused heart. Effect of pacing during ischemia and response to a beta-adrenergic challenge.
Topics: Adrenergic beta-Agonists; Animals; Calcium-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Is | 2003 |
[Effect of wenxin capsule on myocyte apoptosis and expression of Bcl-2, Fas gene protein in rats of experimental myocardial ischemia].
Topics: Animals; Apoptosis; Drug Combinations; Drugs, Chinese Herbal; fas Receptor; Isoproterenol; Male; Myo | 2003 |
[Cardioprotective effect and influence on NOS expression of Montelukast sodium in rats].
Topics: Acetates; Animals; Cardiotonic Agents; Cyclopropanes; Female; Isoproterenol; Leukotriene Antagonists | 2003 |
A case of status asthmaticus complicated by anginal pain and an elevation in blood cpk levels during tapering of isoproterenol administered for management of respiratory failure.
Topics: Adolescent; Biomarkers; Bronchodilator Agents; Creatine Kinase; Electrocardiography; Humans; Isoprot | 2004 |
Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol.
Topics: Alkenes; Animals; Carbon-Oxygen Lyases; Cardiotonic Agents; Creatine Kinase; Free Radical Scavengers | 2004 |
Na+/Ca2+ exchanger plays a key role in inducing apoptosis after hypoxia in cultured guinea pig ventricular myocytes.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Apoptosis; Cells, Cultured; Endothelin | 2004 |
Cardioprotection from ischemia and reperfusion injury by Withania somnifera: a hemodynamic, biochemical and histopathological assessment.
Topics: Animals; Blood Pressure; Catalase; Creatine Kinase; Female; Glutathione; Glutathione Peroxidase; Hea | 2004 |
Ghrelin protects myocardium from isoproterenol-induced injury in rats.
Topics: Animals; Cardiotonic Agents; Endothelin-1; Ghrelin; Isoproterenol; L-Lactate Dehydrogenase; Male; Ma | 2004 |
Male/female differences in intracellular Na+ regulation during ischemia/reperfusion in mouse heart.
Topics: Animals; Cardiotonic Agents; Female; Isoproterenol; Male; Mice; Myocardial Contraction; Myocardial I | 2004 |
Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Aged; Animals; Cardiotonic Agents; Cyclic AMP-Depend | 2004 |
p38 alpha mitogen-activated protein kinase inhibition improves cardiac function and reduces myocardial damage in isoproterenol-induced acute myocardial injury in rats.
Topics: Acute Disease; Animals; Blood Pressure; Body Weight; Cardiotonic Agents; Gene Expression; Injections | 2004 |
[Effect of ginsenoside Rg2 on chemical myocardial ischemia in rats].
Topics: Animals; Creatine Kinase; Electrocardiography; Female; Ginsenosides; Isoproterenol; Male; Malondiald | 2003 |
Effect of relaxin on myocardial ischemia injury induced by isoproterenol.
Topics: Animals; Cardiomegaly; Creatine Kinase; Disease Models, Animal; Endothelins; Gene Expression; Heart; | 2005 |
Contractile effects of adenosine A1 and A2A receptors in isolated murine hearts.
Topics: Adenosine; Animals; Heart; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial | 2006 |
Inhibition of iNOS protects the aging heart against beta-adrenergic receptor stimulation-induced cardiac dysfunction and myocardial ischemic injury.
Topics: Adrenergic beta-Agonists; Aging; Animals; Isoproterenol; Male; Myocardial Infarction; Myocardial Isc | 2006 |
Apelin protects myocardial injury induced by isoproterenol in rats.
Topics: Animals; Apelin; Apelin Receptors; Carrier Proteins; Dose-Response Relationship, Drug; Heart; Interc | 2006 |
Endurance exercise training attenuates cardiac beta2-adrenoceptor responsiveness and prevents ventricular fibrillation in animals susceptible to sudden death.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Citrate (si)-Synthase; Death, Sudden | 2006 |
Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Fibrosis; Ghrelin; Growth Hormone; Isoproterenol; Male; M | 2006 |
Preventive effect of S-allyl cysteine sulfoxide (alliin) on cardiac marker enzymes and lipids in isoproterenol-induced myocardial injury.
Topics: Animals; Cholesterol; Cholesterol, HDL; Cholesterol, VLDL; Creatine Kinase; Creatine Kinase, MB Form | 2006 |
Cardioprotective effect of grape seed proanthocyanidins on isoproterenol-induced myocardial injury in rats.
Topics: Animals; Biomarkers; Biopsy, Needle; Blood Chemical Analysis; Cardiotonic Agents; Disease Models, An | 2007 |
Isomers (oleanolic and ursolic acids) differ in their protective effect against isoproterenol-induced myocardial ischemia in rats.
Topics: Adrenergic beta-Agonists; Animals; Cardiotonic Agents; Isoproterenol; Male; Myocardial Ischemia; Ole | 2007 |
[A pharmacology study of Cyclovirobuxinum D on curing myocardial ischemia induced by isoprenaline].
Topics: Animals; Buxaceae; Drugs, Chinese Herbal; Isoproterenol; Male; Myocardial Ischemia; Myocardium; Plan | 2006 |
The myocardial response to adrenomedullin involves increased cAMP generation as well as augmented Akt phosphorylation.
Topics: Adrenomedullin; Animals; Blotting, Western; Calcitonin Receptor-Like Protein; Cardiotonic Agents; Cy | 2007 |
Cardioprotective effect of oleanolic acid on isoproterenol-induced myocardial ischemia in rats.
Topics: Animals; Biomarkers; Cardiotonic Agents; Clinical Enzyme Tests; Dose-Response Relationship, Drug; Is | 2007 |
Lovastatin specifically prevents focal ischemic ventricular tachycardia due to triggered activity.
Topics: Action Potentials; Adrenergic beta-Agonists; Analysis of Variance; Animals; Anti-Arrhythmia Agents; | 2007 |
Grape seed proanthocyanidins ameliorates isoproterenol-induced myocardial injury in rats by stabilizing mitochondrial and lysosomal enzymes: an in vivo study.
Topics: Adrenergic beta-Agonists; Animals; Cardiomyopathies; Cardiotonic Agents; Electron Transport; Isoprot | 2007 |
[Protective effect of Ophiopogonis polysaccharide MDG-1 on experimental myocardial ischemic rats].
Topics: Animals; Cardiotonic Agents; Coronary Circulation; Drugs, Chinese Herbal; Electrocardiography; Guine | 2007 |
Effects of diesel exhaust particles on left ventricular function in isoproterenol-induced myocardial injury and healthy rats.
Topics: Air Pollutants; Animals; Disease Models, Animal; Drug Synergism; Electrocardiography; Heart; Intubat | 2008 |
Tonic beta-adrenergic drive provokes proinflammatory and proapoptotic changes in aging mouse heart.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Amidines; Animals; Apoptosis; Benzylam | 2008 |
Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress.
Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Cells, Cultured; GTP-Binding Protein alpha Subunit, Gi | 2008 |
Ameliorative prospective of alpha-mangostin, a xanthone derivative from Garcinia mangostana against beta-adrenergic cathecolamine-induced myocardial toxicity and anomalous cardiac TNF-alpha and COX-2 expressions in rats.
Topics: Adrenergic beta-Agonists; Animals; Blotting, Western; Cyclooxygenase 2; Garcinia mangostana; Heart; | 2008 |
New aspects of cyclooxygenase-2 inhibition in myocardial infarction and ischaemia.
Topics: Adrenergic beta-Agonists; Animals; Cardiotonic Agents; Creatine Kinase; Cyclooxygenase 2; Cyclooxyge | 2005 |
[A new and simple method of evaluating left ventricular contractility and its application].
Topics: Animals; Cardiotonic Agents; Dogs; Isoproterenol; Male; Myocardial Contraction; Myocardial Ischemia; | 1995 |
An experimental model of the production of early after depolarizations by injury current from an ischemic region.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
[An observation on the pacemaker current I(f) in sheep cardiac Purkinje fibers under ischemia-mimic condition].
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Ion Channels; Isoproterenol; Membrane | 1995 |
Double-exponential curve fitting of isometric relaxation: a new measure for myocardial lusitropism.
Topics: Animals; Calcium Chloride; Dogs; In Vitro Techniques; Isometric Contraction; Isoproterenol; Models, | 1995 |
[The correction of the hemodynamic disorders in patients with IHD complicated by intraventricular blocks by using beta-adrenergic agents].
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Bundle-Branch Block; Drug Evaluation; | 1995 |
Transient beta adrenergic stimulation can precondition the rat heart against postischaemic contractile dysfunction.
Topics: Adrenergic beta-Agonists; Animals; Arrhythmias, Cardiac; Glycogen; Heart; Isoproterenol; Male; Myoca | 1994 |
Influence of ischaemia and reperfusion on cardiac signal transduction. G protein content, adenylyl cyclase activity, cyclic AMP content, and forskolin and dibutyryl cyclic AMP-induced inotropy in the rat Langendorff heart.
Topics: Adenylyl Cyclases; Animals; Bucladesine; Colforsin; Cyclic AMP; GTP-Binding Proteins; Heart; In Vitr | 1994 |
1H NMR detection of lactate and alanine in perfused rat hearts during global and low pressure ischemia.
Topics: Alanine; Animals; Glycogen; Heart; Isoproterenol; Lactates; Lactic Acid; Magnetic Resonance Spectros | 1995 |
Neutral endopeptidase in the heart. Neutral endopeptidase inhibition prevents isoproterenol-induced myocardial hypoperfusion in rats by reducing bradykinin degradation.
Topics: Animals; Bradykinin; Cells, Cultured; Coronary Circulation; Fluorescent Antibody Technique; Hemodyna | 1994 |
Mechanisms mediating responsiveness to beta-adrenergic stimulation after coronary reperfusion in conscious dogs.
Topics: Amino Acid Sequence; Animals; Blood Pressure; Colforsin; Coronary Vessels; Dogs; Electrophoresis, Po | 1994 |
Antiarrhythmic effects of BN-063, a newly synthesized adenosine A1 agonist, on myocardial ischaemia in rats.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Female; Guanosine; Isoproterenol; Male; Myoca | 1994 |
Impaired endothelium-dependent relaxation after coronary reperfusion injury: evidence for G-protein dysfunction.
Topics: Acetylcholine; Adenosine Diphosphate; Aluminum Chloride; Aluminum Compounds; Animals; Calcimycin; Ca | 1994 |
Comparison of the effects of dobutamine and isoproterenol in ischemic hearts by phosphorus-31 nuclear magnetic resonance spectroscopy.
Topics: Animals; Coronary Circulation; Dobutamine; Dogs; Female; Hemodynamics; Isoproterenol; Lactates; Lact | 1994 |
Preserved beta-adrenoceptor-mediated adenylyl cyclase activity despite receptor and postreceptor dysfunction in acute myocardial ischemia.
Topics: Adenylyl Cyclases; Animals; Female; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Isoproterenol; | 1994 |
Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Anesthesia; Animals; Arrhythmias, Cardiac; Blood Pressu | 1993 |
Sensitivity to ischaemic ATP breakdown in different models of cardiac hypertrophy in rats.
Topics: Adenosine Triphosphate; Animals; Cardiomegaly; Coronary Circulation; Hyperemia; Hypertension; Isopro | 1994 |
[Myocardial ischemia detected by isoproterenol stress cardiac blood-pool scintigraphy: significance of asynchrony as an index of myocardial ischemia].
Topics: Adult; Aged; Coronary Disease; Exercise Test; Female; Humans; Isoproterenol; Male; Middle Aged; Myoc | 1993 |
Lack of modulation by dietary unsaturated fats on sympathetic neurotransmission in rat hearts.
Topics: Animals; Dietary Fats; Electric Stimulation; Fats, Unsaturated; Fatty Acids; Fatty Acids, Omega-6; F | 1993 |
Ischemic preconditioning is associated with a delay in ischemia-induced reduction of beta-adrenergic signal transduction in rabbit hearts.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Colforsin; Female; | 1993 |
Regional myocardial downregulation of the inhibitory guanosine triphosphate-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model of chronic episodic myocardial ischemia.
Topics: Adenylyl Cyclases; Animals; Base Sequence; Cell Membrane; Coronary Circulation; Disease Models, Anim | 1993 |
Beneficial effect of amrinone on the size of acute regional ischemia in isolated rabbit hearts.
Topics: Amrinone; Animals; Blood Pressure; Coronary Circulation; Fluorescence; Histocytochemistry; In Vitro | 1993 |
Adenosine and A1 selective agonists offer minimal protection against ischaemic injury to isolated rat cardiomyocytes.
Topics: Adenosine; Animals; Carbachol; Cell Death; Cells, Cultured; Iodoacetates; Iodoacetic Acid; Isoproter | 1993 |
[Cardioprotection of 2-[p-(dimethylamino)styryl]pyridine methiodide against ischemic damage and myocardial lipid peroxidation].
Topics: Animals; Calcium Channel Blockers; Female; Isoproterenol; Lipid Peroxidation; Male; Mice; Mice, Inbr | 1993 |
Hypoxia enhances isoproterenol-induced increase in heart interstitial adenosine, depressing beta-adrenergic contractile responses.
Topics: Adenosine; Animals; Cell Hypoxia; Disease Models, Animal; Heart; Isoproterenol; Male; Myocardial Con | 1993 |
Increased release of NO during ischemia reduces myocardial contractility and improves metabolic dysfunction.
Topics: Animals; Arginine; Calcium Chloride; Dogs; Hydrogen-Ion Concentration; Isoproterenol; Lactates; Lact | 1996 |
Endogenous adenosine reduces depression of cardiac function induced by beta-adrenergic stimulation during low flow perfusion.
Topics: Adenosine; Adrenergic beta-Agonists; Animals; Arrhythmias, Cardiac; Coronary Circulation; Epinephrin | 1995 |
Protective effects of All-trans-retinoic acid against cardiac arrhythmias induced by isoproterenol, lysophosphatidylcholine or ischemia and reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cells, Cultured; Isoproterenol; Lysophosphati | 1995 |
A novel catecholamine, arbutamine, for a pharmacological cardiac stress agent.
Topics: Animals; Cardiotonic Agents; Catecholamines; Dobutamine; Dogs; Exercise Test; Half-Life; Hemodynamic | 1996 |
Metabolic fate of glucose in reversible low-flow ischemia of the isolated working rat heart.
Topics: Animals; Cardiotonic Agents; Glucose; Heart Rate; Isoproterenol; Male; Myocardial Ischemia; Myocardi | 1996 |
Effects of a new calcium antagonist, CD-832, on isoproterenol-induced myocardial ischemia in dogs with partial coronary stenosis.
Topics: Angina Pectoris; Animals; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiaze | 1996 |
Endogenous adenosine increases O2 utilisation efficiency in isoprenaline-stimulated canine myocardium.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adrenergic beta-Agonists; Animals; Dogs; Hypoxia; Isoproter | 1996 |
Myocardial ischemia alters immunoregulatory cell traffic and function in the rat independent of exogenous catecholamine administration.
Topics: Adrenergic beta-Agonists; Animals; Catecholamines; Isoproterenol; Lymphocyte Activation; Lymphocyte | 1996 |
Cardiac beta-adrenoreceptor activation and ventricular fibrillation under normal and ischemic conditions.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Cardiac Pacing, Artificial; Electric Stimulati | 1996 |
Isoproterenol mimics calcium preconditioning-induced protection against ischemia.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Beta-adrenoceptor-linked signal transduction in ischemic-reperfused heart and scavenging of oxyradicals.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Catalase; Cell Membra | 1997 |
Beta-adrenoceptor stimulation-mediated preconditioning-like cardioprotection in perfused rat hearts.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A | 1997 |
K(ATP) channels contribute to the cardioprotection of preconditioning independent of anaesthetics in rabbit hearts.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Anesthetics; Animals; Cardiotonic Agents; Female; Hemodyn | 1997 |
Increased cardiac workload by adrenoceptor agonists for the estimation of potential antiischemic activity in a conscious rabbit model.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Cardiac Pacing, Artificial; Disease Mo | 1997 |
Beta2-adrenergic receptor antagonists protect against ventricular fibrillation: in vivo and in vitro evidence for enhanced sensitivity to beta2-adrenergic stimulation in animals susceptible to sudden death.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Agonist | 1997 |
Beta-adrenergic signal transduction and contractility in the canine heart after cardiopulmonary bypass.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Analysis of Variance; Animals; Cardiopulmonary Bypass; | 1997 |
Pharmacological characterization of coronary small arteries from pigs with chronic ischaemic myocardial remodelling.
Topics: Acetylcholine; Animals; Bradykinin; Cardiomegaly; Cardiotonic Agents; Chronic Disease; Coronary Vess | 1998 |
Efficacy of a beta-adrenergic receptor antagonist, propranolol, in preventing ischaemic ventricular fibrillation: dependence on heart rate and ischaemia duration.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Cardiac Pacing | 1998 |
Beta-adrenergic stimulation of reperfused myocardium after 2-hour ischemia.
Topics: Adrenergic beta-Agonists; Animals; Dogs; Female; Hemodynamics; Isoproterenol; Male; Myocardial Contr | 1998 |
Effect of a novel tetrapeptide derivative in a model of isoproterenol induced myocardial necrosis.
Topics: Adrenergic beta-Agonists; Animals; Aspirin; Body Weight; Creatine Kinase; Disease Models, Animal; Fe | 1998 |
Regulation of the Ca2+ gradient across the sarcoplasmic reticulum in perfused rabbit heart. A 19F nuclear magnetic resonance study.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium-Binding Proteins; Fluorine Radioisotopes; Ischemic | 1998 |
Myocardial ischaemia and infarction in isoprenaline-treated rabbits: role of cyclooxygenases.
Topics: Adrenergic beta-Agonists; Animals; Aspirin; Cyclooxygenase Inhibitors; Electrocardiography; Isoprote | 1998 |
Significant complications can occur with ischemic heart disease and tilt table testing.
Topics: Adrenergic beta-Agonists; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Bundle-Branch Blo | 1999 |
Contribution of alpha-adrenergic and beta-adrenergic stimulation to ischemia-induced glucose transporter (GLUT) 4 and GLUT1 translocation in the isolated perfused rat heart.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A | 1999 |
Nonischemic end-systolic performance. Effect of alterations in regional and global left ventricular contractility.
Topics: Animals; Dobutamine; Dogs; Dose-Response Relationship, Drug; Female; Hemodynamics; Infusions, Intra- | 1999 |
An inhibitor of poly (ADP-ribose) synthetase activity reduces contractile dysfunction and preserves high energy phosphate levels during reperfusion of the ischaemic rat heart.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Cardiotonic Agents; Diastole; Enzyme Inhibitors; He | 1999 |
Effects of different vasodilators on human internal mammary artery in vitro.
Topics: Ethanolamines; Female; Humans; In Vitro Techniques; Isoproterenol; Isosorbide Dinitrate; Male; Mamma | 1999 |
Comparison of bisoprolol and carvedilol cardioprotection in a rabbit ischemia and reperfusion model.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Antioxidants; Bisoprolol; Carbazoles | 2000 |
Influence of beta-adrenoceptor tone on the cardioprotective efficacy of adenosine A(1) receptor activation in isolated working rat hearts.
Topics: Adrenergic beta-Agonists; Animals; Heart; In Vitro Techniques; Isoproterenol; Male; Myocardial Ische | 2000 |
Ischemic inactivation of G protein-coupled receptor kinase and altered desensitization of canine cardiac beta-adrenergic receptors.
Topics: Adenylyl Cyclases; Animals; beta-Adrenergic Receptor Kinases; Binding, Competitive; Blotting, Wester | 2000 |
Effect of SMP-300, a new Na+/H+ exchange inhibitor, on myocardial ischemia and experimental angina models in rats.
Topics: Amiloride; Angina Pectoris; Animals; Azocines; Blood Pressure; Disease Models, Animal; Electrocardio | 2000 |
[Effects of isoprenaline on apoptosis related gene expression in rat myocardium cells].
Topics: Animals; Apoptosis; Cardiotonic Agents; Disease Models, Animal; Gene Expression; Isoproterenol; Male | 2000 |
Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium.
Topics: Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Adult; Biopsy; Blotting, Western; Car | 2001 |
p38 MAPK activation triggers pharmacologically-induced beta-adrenergic preconditioning, but not ischaemic preconditioning.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alprenolol; Animals; Enzyme Activation; Enzym | 2001 |
[Study on the protective effect of xinkang oral liquid on the isoproterenol-induced ischemic myocardial damage in rats].
Topics: Animals; Drugs, Chinese Herbal; Female; Isoproterenol; Male; Myocardial Ischemia; Phytotherapy; Rats | 2001 |
Effect of diabetes mellitus on hemodynamic and cardiometabolic correlates in experimental myocardial infarction.
Topics: Analysis of Variance; Animals; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Animal; | 2001 |
Antiarrhythmic efficacy of combined I(Ks) and beta-adrenergic receptor blockade.
Topics: Acetamides; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; | 2002 |
Effect of propranolol and isoprenaline on regional left ventricular blood flow in experimental myocardial ischaemia.
Topics: Animals; Coronary Circulation; Dogs; Electrocardiography; Heart Ventricles; Isoproterenol; Microsphe | 1975 |
[Anti-lipid peroxidation and protective effects of phenytoin sodium on ischemic myocardium of mice].
Topics: Animals; Female; Glutathione Peroxidase; Isoproterenol; Lipid Peroxidation; Male; Malondialdehyde; M | 1992 |
Investigation of antiischemic properties and mechanism of action of azacrown ether derivative.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Cats; Crown Ethers; Electrocardiography; Ethers, Cy | 1992 |
Alterations in the beta-adrenergic receptor system after hypothermic ischemia in hearts with preischemic beta-receptor desensitization.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Cell Membrane; Hear | 1992 |