isoproterenol has been researched along with Lymphoma in 100 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report here that desensitization of the beta-adrenergic receptor-triggered transmembrane signalling in S49 wild-type lymphoma cells, induced by (-)-isoproterenol (1 microM), results in unequal intracellular redistribution of the splicing variants of the alpha subunit of the stimulatory guanine-nucleotide-binding regulatory (Gs alpha) protein (Gs alpha-short and Gs alpha-long) and alters the functional characteristics of the membrane-associated signal transduction complex." | 7.69 | The short and long forms of the alpha subunit of the stimulatory guanine-nucleotide-binding protein are unequally redistributed during (-)-isoproterenol-mediated desensitization of intact S49 lymphoma cells. ( Kvapil, P; Novotny, J; Ransnäs, LA; Svoboda, P, 1994) |
| " Subsequently, this ELISA was used for quantitation of the beta subunit in subcellular fractions of S49 lymphoma cells during isoproterenol-mediated desensitization of beta-adrenergic controlled transmembrane signalling system." | 7.69 | Isoproterenol-induced subcellular redistribution of G-protein beta subunits in S49 lymphoma cells demonstrated by a novel competitive ELISA. ( Bokoch, GM; Kvapil, P; Novotny, J; Ransnäs, LA, 1995) |
| "We report here that desensitization of the beta-adrenergic receptor-triggered transmembrane signalling in S49 wild-type lymphoma cells, induced by (-)-isoproterenol (1 microM), results in unequal intracellular redistribution of the splicing variants of the alpha subunit of the stimulatory guanine-nucleotide-binding regulatory (Gs alpha) protein (Gs alpha-short and Gs alpha-long) and alters the functional characteristics of the membrane-associated signal transduction complex." | 3.69 | The short and long forms of the alpha subunit of the stimulatory guanine-nucleotide-binding protein are unequally redistributed during (-)-isoproterenol-mediated desensitization of intact S49 lymphoma cells. ( Kvapil, P; Novotny, J; Ransnäs, LA; Svoboda, P, 1994) |
| " Subsequently, this ELISA was used for quantitation of the beta subunit in subcellular fractions of S49 lymphoma cells during isoproterenol-mediated desensitization of beta-adrenergic controlled transmembrane signalling system." | 3.69 | Isoproterenol-induced subcellular redistribution of G-protein beta subunits in S49 lymphoma cells demonstrated by a novel competitive ELISA. ( Bokoch, GM; Kvapil, P; Novotny, J; Ransnäs, LA, 1995) |
| "We have assessed the possible interaction between the microtubular component of the cytoskeleton and signal transducing GTP-binding (G) proteins by examining the ability of colchicine and vinblastine (two microtubule disrupters) to alter Gs and Gi protein activity in S49 lymphoma cells." | 3.68 | Alteration in Gs-mediated signal transduction in S49 lymphoma cells treated with inhibitors of microtubules. ( Alousi, AA; Bernstein, D; Insel, PA; Jasper, JR; Leiber, D; Martin, J, 1993) |
| "We have tested the effects of carteolol and 8-hydroxycarteolol on cAMP generation in S49 lymphoma and BC3H1 smooth muscle-like cells." | 3.68 | The beta-adrenoceptor antagonist carteolol and its metabolite 8-hydroxycarteolol have different intrinsic sympathomimetic activities. ( Insel, PA; Jasper, JR; Michel, MC, 1990) |
| " The beta-adrenergic activities of these new compounds were assessed through measurement of intracellular cyclic AMP accumulation in S49 mouse lymphoma cells and displacement of iodocyanopindolol (ICYP) from membrane preparations." | 3.67 | Conjugates of catecholamines. 5. Synthesis and beta-adrenergic activity of N-(aminoalkyl)norepinephrine derivatives. ( Akita, Y; Castagnoli, N; Goodman, M; Hoffman, BB; Melmon, KL; Reitz, AB; Rosenkranz, RP; Sonveaux, E; Verlander, MS, 1985) |
| " Functional vasoactive intestinal peptide (VIP)/helodermin receptors and beta 2-adrenoceptors coexist in membranes from a cultured cloned BL/VL3 cell line of murine T-cell lymphoma induced by a radiation leukemia virus (see preceding paper in this journal)." | 3.67 | Homologous and heterologous regulation of the helodermin/vasoactive-intestinal-peptide response in the murine radiation leukemia-virus-induced lymphoma cell line BL/VL3. ( Abello, J; Christophe, J; Damien, C; Hooghe, R; Robberecht, P; Vandermeers, A; Vandermeers-Piret, MC, 1989) |
| " In the current studies we tested whether Gs redistributes within cells by treating S49 lymphoma cells with the beta-adrenergic agonist isoproterenol, then separating cytosol and crude membrane fractions (defined as pellet and supernatant, respectively, after centrifugation for 1 hr at 150,000 x g), and assaying fractions for the alpha subunit of Gs (alpha s) using a competitive ELISA and reconstitution techniques." | 3.67 | Stimulation of beta-adrenergic receptors of S49 lymphoma cells redistributes the alpha subunit of the stimulatory G protein between cytosol and membranes. ( Insel, PA; Jasper, JR; Ransnäs, LA; Svoboda, P, 1989) |
| "beta-Adrenergic receptors on membranes prepared from L6 myoblasts, wild-type S49 lymphoma cells, and an adenylate cyclase-deficient variant (cyc-) of S49 lymphoma cells bind the agonist [3H]hydroxybenzylisoproterenol ([3H]HBI) with high affinity." | 3.67 | Interaction of beta-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells. ( Abramson, SN; Barrett, DA; Harden, TK; Hughes, AR; Martin, MW; Molinoff, PB; Neve, KA, 1988) |
| "Addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) to S49 lymphoma cells (wild type and a cyclic AMP-dependent protein kinase-lacking clone) has little effect alone but doubles accumulation of cyclic AMP in response to isoproterenol." | 3.67 | Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Putative effect of C kinase on alpha s-GTP-catalytic subunit interaction. ( Bell, JD; Brunton, LL; Buxton, IL, 1985) |
| " The beta-adrenergic agonist activity of the derivatives was evaluated in vitro by measuring the intracellular accumulation of cyclic AMP in S49 mouse lymphoma cells and by the displacement of iodocyanopindolol (ICYP)." | 3.67 | Conjugates of catecholamines. 6. Synthesis and beta-adrenergic activity of N-(hydroxyalkyl)catecholamine derivatives. ( Akita, Y; Avery, MA; Castagnoli, N; Goodman, M; Hoffman, BB; Melmon, KL; Reitz, AB; Rosenkranz, RP; Verlander, MS, 1985) |
| "The ability of the atypical agonists celiprolol and pindolol to induce sequestration and down regulation of beta adrenergic receptors was investigated in S49 lymphoma cells." | 3.67 | Down regulation of beta adrenergic receptors in S49 lymphoma cells induced by atypical agonists. ( Molinoff, PB; Reynolds, EE, 1986) |
| " In the current studies, we show that several beta AR antagonists with ISA (dichloroisoproterenol, pindolol, and celiprolol) stimulate cAMP accumulation five-, two-, and threefold, respectively, in S49 lymphoma cells, but only if cells are simultaneously incubated with the diterpene forskolin." | 3.67 | Molecular mechanism of beta-adrenergic receptor blockers with intrinsic sympathomimetic activity. ( Insel, PA; Jasper, JR; Michel, MC, 1988) |
| "Brief (approximately 20-min) exposure of S49 lymphoma cells to beta-agonists such as isoproterenol leads to a homologous form of desensitization in which beta-agonist but not prostaglandin E1-sensitive or NaF-sensitive adenylate cyclase is reduced." | 3.67 | Homologous desensitization of beta-adrenergic receptor coupled adenylate cyclase. Resensitization by polyethylene glycol treatment. ( Lefkowitz, RJ; Strasser, RH, 1985) |
| "The radiolabeled agonist [3H]hydroxybenzylisoproterenol ([3H]HBI) and antagonist [125I]iodopindolol ([125I]IPIN) were used to investigate the properties of beta-adrenergic receptors on membranes prepared from L6 myoblasts and S49 lymphoma cells." | 3.67 | Properties of beta-adrenergic receptors of cultured mammalian cells. Interaction of receptors with a guanine nucleotide-binding protein in membranes prepared from L6 myoblasts and from wild-type and cyc- S49 lymphoma cells. ( Abramson, SN; Molinoff, PB, 1985) |
| "The potency of a p-toluide derivative and a p-trifluoromethyl derivative of isoproterenol on the beta1 receptor of turkey erythrocytes and on the beta2 receptor of S49 lymphoma cells was measured in comparison with isoproterenol." | 3.67 | High potency congeners of isoproterenol. Binding to beta-adrenergic receptors, activation of adenylate cyclase and stimulation of intracellular cyclic AMP synthesis. ( Eimerl, S; Goodman, M; Khan, MM; Melmon, K; Schramm, M; Verlander, MS, 1986) |
| "Bromoacetylalprenololmenthane was found to inhibit hormone-induced beta-adrenergic receptor internalization in a dose-dependent fashion in S49 lymphoma cells, besides its known ability to bind to beta-receptors irreversibly." | 3.67 | Bromoacetylalprenololmenthane binding to beta-receptors modulates the rate of hormone-induced internalization but not desensitization in S49 cells. ( Box, RJ; Staehelin, M, 1987) |
| "Beta-adrenergic receptors on membranes prepared from rat lung, wild-type S49 lymphoma cells, and the adenylate cyclase-deficient variant of S49 lymphoma cells (cyc-) bind the agonist [3H]hydroxybenzylisoproterenol ([3H]HBI) with high affinity and this binding of [3H]HBI can be inhibited by GTP." | 3.67 | Interactions of beta-adrenergic receptors with a membrane protein other than the stimulatory guanine nucleotide-binding protein. ( Abramson, SN; Molinoff, PB; Shorr, RG, 1987) |
| " In two cell lines, C6 glioma and WEHI 7 lymphoma cells, -50% of the cell surface receptors disappear within minutes of incubation of the cells with isoproterenol." | 3.66 | Rapid and reversible disappearance of beta-adrenergic cell surface receptors. ( Simons, P; Staehelin, M, 1982) |
| "A mouse lymphoma tissue culture line, S49, is killed by isoproterenol, choleratoxin, or prostaglandin E1, inducers of cyclic AMP (cAMP) in these cells, or by the analog dibutyryl (db) cAMP." | 3.65 | Mechanism of lymphoma cell death induced by cyclic AMP. ( Bourne, HR; Coffino, P; Tomkins, GM, 1975) |
| "Treatment with propranolol slightly enhanced the proliferation of the RC-2A cells but did not markedly alter the growth rate of two other cell lines, regardless of their beta-adrenoceptor status." | 1.28 | Expression and function of beta-adrenergic receptors in human hematopoietic cell lines. ( Andersson, LC; Kontula, KK; Mäki, T, 1992) |
| " Ethanol also shifted the dose-response curve for stimulation of the enzyme by isoproterenol to the right." | 1.27 | Effects of ethanol in vitro on the beta adrenergic receptor-coupled adenylate cyclase system. ( Bode, DC; Molinoff, PB, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 79 (79.00) | 18.7374 |
| 1990's | 15 (15.00) | 18.2507 |
| 2000's | 6 (6.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Reitz, AB | 2 |
| Sonveaux, E | 1 |
| Rosenkranz, RP | 4 |
| Verlander, MS | 4 |
| Melmon, KL | 6 |
| Hoffman, BB | 4 |
| Akita, Y | 2 |
| Castagnoli, N | 2 |
| Goodman, M | 6 |
| Matousek, P | 2 |
| Novotný, J | 4 |
| Svoboda, P | 4 |
| Rudajev, V | 1 |
| Jakobs, KH | 1 |
| Minuth, M | 1 |
| Aktories, K | 1 |
| Maguire, ME | 7 |
| Erdos, JJ | 3 |
| Vauquelin, G | 2 |
| Cech, SY | 2 |
| Broaddus, WC | 1 |
| Jacobs, PL | 1 |
| Jacobson, KA | 2 |
| Verlander, M | 2 |
| Klevans, L | 1 |
| O'Donnell, M | 1 |
| Burchiel, SW | 1 |
| Hanson, K | 1 |
| Warner, NL | 1 |
| Iyengar, R | 5 |
| Abramowitz, J | 1 |
| Bordelon-Riser, M | 1 |
| Blume, AJ | 1 |
| Birnbaumer, L | 4 |
| Nielsen, TB | 1 |
| Downs, RW | 1 |
| Spiegel, AM | 1 |
| Bhat, MK | 1 |
| Riser, ME | 1 |
| Darfler, FJ | 3 |
| Hughes, RJ | 1 |
| Insel, PA | 24 |
| Seamon, K | 1 |
| Daly, JW | 1 |
| Steinberg, RA | 3 |
| Agard, DA | 1 |
| Honeysett, JM | 1 |
| Koachman, AM | 4 |
| Mahan, LC | 7 |
| Swillens, S | 1 |
| André, C | 1 |
| Strosberg, AD | 1 |
| Motulsky, HJ | 3 |
| Stoolman, LM | 1 |
| Mullen, MD | 1 |
| Staehelin, M | 3 |
| Simons, P | 1 |
| Somkuti, SG | 1 |
| Hildebrandt, JD | 2 |
| Herberg, JT | 1 |
| Gonzales, JM | 1 |
| Kvapil, P | 2 |
| Ransnäs, LA | 5 |
| Leiber, D | 2 |
| Jasper, JR | 7 |
| Alousi, AA | 2 |
| Martin, J | 1 |
| Bernstein, D | 1 |
| Masuda, H | 1 |
| Kaneko, M | 1 |
| Hong, RB | 1 |
| Ikegaya, T | 1 |
| Hayashi, H | 1 |
| Kobayashi, A | 1 |
| Yamazaki, N | 1 |
| Bokoch, GM | 1 |
| Gu, C | 1 |
| Ma, YC | 1 |
| Benjamin, J | 1 |
| Littman, D | 1 |
| Chao, MV | 1 |
| Huang, XY | 1 |
| Yan, L | 1 |
| Herrmann, V | 1 |
| Hofer, JK | 1 |
| Zhang, L | 1 |
| Yu, JZ | 1 |
| Rasenick, MM | 1 |
| Haga, T | 1 |
| Ross, EM | 2 |
| Anderson, HJ | 1 |
| Gilman, AG | 4 |
| Johnson, GL | 3 |
| Bourne, HR | 7 |
| Gleason, MK | 1 |
| Coffino, P | 3 |
| Kennedy, MS | 2 |
| Tomkins, GM | 4 |
| Sturgill, TW | 1 |
| Biltonen, RL | 1 |
| Bird, SJ | 1 |
| Burgess, WH | 1 |
| Howlett, AC | 1 |
| Kretsinger, RH | 1 |
| Sanda, M | 1 |
| Steinberg, MG | 1 |
| van Daalen Wetters, T | 1 |
| Kaslow, HR | 1 |
| Farfel, Z | 1 |
| Sternweis, PC | 1 |
| Morgan, AJ | 1 |
| Murray, KJ | 1 |
| Challiss, RA | 1 |
| Mäki, T | 1 |
| Andersson, LC | 1 |
| Kontula, KK | 1 |
| Motojima, S | 1 |
| Toda, M | 1 |
| Fukuda, T | 1 |
| Makino, S | 1 |
| Davies, AO | 1 |
| Su, CJ | 1 |
| Balasubramanyam, A | 1 |
| Codina, J | 1 |
| Chaudhry, A | 1 |
| Granneman, JG | 1 |
| Kohnken, RE | 1 |
| Michel, MC | 2 |
| Rubin, JE | 1 |
| Chenoweth, DE | 1 |
| Catherwood, BD | 1 |
| Pipkin, JL | 1 |
| Anson, JF | 1 |
| Hinson, WG | 1 |
| Burns, ER | 1 |
| Casciano, DA | 1 |
| Journot, L | 1 |
| Bockaert, J | 1 |
| Audigier, Y | 1 |
| Abello, J | 1 |
| Damien, C | 1 |
| Robberecht, P | 1 |
| Hooghe, R | 1 |
| Vandermeers, A | 1 |
| Vandermeers-Piret, MC | 1 |
| Christophe, J | 1 |
| Hadcock, JR | 1 |
| Ros, M | 1 |
| Malbon, CC | 1 |
| Rich, KA | 1 |
| Thomas, JM | 1 |
| Strasser, RH | 3 |
| Benovic, JL | 1 |
| Lefkowitz, RJ | 3 |
| Caron, MG | 1 |
| Bode, DC | 1 |
| Molinoff, PB | 6 |
| Abramson, SN | 4 |
| Martin, MW | 1 |
| Hughes, AR | 1 |
| Harden, TK | 1 |
| Neve, KA | 1 |
| Barrett, DA | 1 |
| Bell, JD | 3 |
| Buxton, IL | 1 |
| Brunton, LL | 3 |
| Avery, MA | 1 |
| Reynolds, EE | 2 |
| Hoyer, D | 1 |
| Fukuda, M | 1 |
| Beechan, CM | 1 |
| Khan, MM | 2 |
| Marbach, I | 1 |
| Shiloach, J | 1 |
| Levitzki, A | 1 |
| Kiss, Z | 1 |
| Müller, P | 1 |
| Portenier, M | 1 |
| Harris, AW | 1 |
| Shane, E | 2 |
| Yeh, M | 2 |
| Feigin, AS | 2 |
| Owens, JM | 2 |
| Bilezikian, JP | 2 |
| Sibley, DR | 1 |
| Schramm, M | 1 |
| Eimerl, S | 1 |
| Melmon, K | 1 |
| Grubbs, RD | 1 |
| Nukada, T | 1 |
| Mishina, M | 1 |
| Numa, S | 1 |
| Box, RJ | 1 |
| Shorr, RG | 1 |
| O'Brien, DR | 1 |
| Barber, R | 1 |
| Daniel, V | 1 |
| Dion, S | 1 |
100 other studies available for isoproterenol and Lymphoma
| Article | Year |
|---|---|
Conjugates of catecholamines. 5. Synthesis and beta-adrenergic activity of N-(aminoalkyl)norepinephrine derivatives.
Topics: Adrenergic beta-Agonists; Animals; Binding, Competitive; Cyclic AMP; In Vitro Techniques; Iodocyanop | 1985 |
Resolution of G(s)alpha and G(q)alpha/G(11)alpha proteins in membrane domains by two-dimensional electrophoresis: the effect of long-term agonist stimulation.
Topics: Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimen | 2004 |
Prolonged agonist stimulation does not alter the protein composition of membrane domains in spite of dramatic changes induced in a specific signaling cascade.
Topics: Adrenergic beta-Agonists; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoresis, Gel, T | 2005 |
Sodium regulation of hormone-sensitive adenylate cyclase.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adipose Tissue; Alprostadil; Animals; Blood Platelet | 1984 |
Inhibition of magnesium uptake by beta-adrenergic agonists and prostaglandin E1 is not mediated by cyclic AMP.
Topics: Adrenergic beta-Antagonists; Animals; Biological Transport; Cell Line; Cholera Toxin; Cyclic AMP; Is | 1980 |
Magnesium transport: an independently regulated beta-adrenergic response not mediated by cyclic AMP.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Biological Transport; Cell Line; Cell Membr | 1981 |
In vitro and in vivo betamimetic activity of congeners of isoproterenol.
Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Chemical Phenomena; Chemistry; Cyclic AMP; In Vit | 1982 |
Conjugates of catecholamines. II. In vitro and in vivo pharmacological activity of N-alkyl-functionalized carboxylic acid congeners and amides related to isoproterenol.
Topics: Adrenergic beta-Antagonists; Airway Resistance; Amides; Animals; Blood Pressure; Carboxylic Acids; D | 1983 |
Clonal heterogeneity of cyclic AMP responsiveness: a comparison of malignant murine lymphoid cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; B-Lymphocytes; Cell Line; Cells, Cultured; Cholera Toxin; Clon | 1984 |
Regulation of hormone-receptor coupling to adenylyl cyclase. Effects of GTP and GDP.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; Corpus Luteum; Erythrocyte Membrane; Female; G | 1980 |
Restoration of guanine nucleotide- and fluoride-stimulated activity to an adenylate cyclase-deficient cell line with affinity-purified guanine nucleotide regulatory protein.
Topics: Adenylyl Cyclases; Carrier Proteins; Cell Line; Chromatography, Affinity; Enzyme Activation; Erythro | 1980 |
Receptor-specific desensitization of the S49 lymphoma cell adenylyl cyclase. Unaltered behavior of the regulatory component.
Topics: Adenylyl Cyclases; Animals; Cell Line; Enzyme Activation; Fluorides; Guanosine Triphosphate; Guanyly | 1981 |
Characterization of serum-induced alterations in the cyclic AMP pathway in S49 lymphoma cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Blood; Cell Line; Cholera Toxin; Cu | 1981 |
Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; Colforsin; Diterpenes; Enzyme Activation; GTP- | 1981 |
Agonist-specific desensitization: molecular locus and possible mechanism.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; Cyclic AMP; Enzyme Activation; Guanylyl Imidod | 1981 |
Turnover of regulatory subunit of cyclic AMP-dependent protein kinase in S49 mouse lymphoma cells. Regulation by catalytic subunit and analogs of cyclic AMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Cell Line; Cholera Toxin; Cyclic AMP; | 1981 |
Inhibition of ornithine decarboxylase and S-adenosylmethionine decarboxylase activities of S49 lymphoma cells by agents increasing cyclic AMP.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosylmethionine Decarboxylase; Alprostadil; Bucla | 1981 |
Cytochalasin B enhances hormone and cholera toxin-stimulated cyclic AMP accumulation in S49 lymphoma cells.
Topics: Adenylyl Cyclases; Alprostadil; Animals; Cell Line; Cholera Toxin; Cyclic AMP; Cytochalasin B; Cytos | 1982 |
Stimulation of forskolin of intact S49 lymphoma cells involves the nucleotide regulatory protein of adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Cell Line; Colforsin; Cyclic AMP; Diterpenes; Dose-Response Relationship | 1982 |
Modulation of catecholamine activation of adenylate cyclase by the number of active beta-adrenergic receptors: theoretical considerations on the role of receptor diffusion in the cell membrane.
Topics: Adenylyl Cyclases; Animals; Blood Proteins; Catecholamines; Cell Line; Cell Membrane; Diffusion; GTP | 1982 |
Distinctions in beta-adrenergic receptor interactions with the magnesium-guanine nucleotide coupling proteins in turkey erythrocyte and S49 lymphoma membranes.
Topics: Animals; Blood Proteins; Cell Membrane; Edetic Acid; Erythrocyte Membrane; Erythrocytes; GTP-Binding | 1982 |
Time-dependent decreases in binding affinity of agonists for beta-adrenergic receptors of intact S49 lymphoma cells. A mechanism of desensitization.
Topics: Animals; Binding, Competitive; Cell Line; Cell Membrane; Cyclic AMP; Iodocyanopindolol; Isoprotereno | 1983 |
Serum-stimulated cyclic-AMP production in S49 lymphoma cells grown in serum-free medium.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antihypertensive Agents; Blood; Cell Line; Colforsin; | 1984 |
Rapid and reversible disappearance of beta-adrenergic cell surface receptors.
Topics: Animals; Cell Line; Endocytosis; Glioma; Isoproterenol; Lymphoma; Propanolamines; Receptors, Adrener | 1982 |
Use of superoxide dismutase and catalase to protect catecholamines from oxidation in tissue culture studies.
Topics: Animals; Antioxidants; Catalase; Catecholamines; Cell Line; Chromatography; Culture Techniques; Isop | 1984 |
Divalent cation regulation of adenylyl cyclase. An allosteric site on the catalytic component.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; Edetic Acid; Erythrocy | 1982 |
Hormone-sensitive magnesium transport in murine S49 lymphoma cells: characterization and specificity for magnesium.
Topics: Animals; Biological Transport; Calcium; Cells, Cultured; Hormones; Hot Temperature; Hydrogen-Ion Con | 1983 |
Anesthetic barbiturates enhance Gs alpha-dependent cyclic AMP production in S49 mouse lymphoma cells.
Topics: Anesthetics; Animals; Barbiturates; Cyclic AMP; Dose-Response Relationship, Drug; GTP-Binding Protei | 1995 |
The short and long forms of the alpha subunit of the stimulatory guanine-nucleotide-binding protein are unequally redistributed during (-)-isoproterenol-mediated desensitization of intact S49 lymphoma cells.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Cyclic AMP; GTP-Binding Proteins; Isoproterenol; Lymphoma | 1994 |
Alteration in Gs-mediated signal transduction in S49 lymphoma cells treated with inhibitors of microtubules.
Topics: Adenylyl Cyclases; Catalysis; Cholera Toxin; Colchicine; Colforsin; Cyclic AMP; GTP-Binding Proteins | 1993 |
Effects of hydrogen peroxide on stimulatory guanine nucleotide-binding protein in rat heart.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Binding Sites; Colforsin; Cyclic AMP; Dihyd | 1993 |
Isoproterenol-induced subcellular redistribution of G-protein beta subunits in S49 lymphoma cells demonstrated by a novel competitive ELISA.
Topics: Adrenergic beta-Agonists; Amino Acid Sequence; Binding, Competitive; Cell Membrane; Detergents; Dime | 1995 |
Apoptotic signaling through the beta -adrenergic receptor. A new Gs effector pathway.
Topics: Animals; Apoptosis; Cell Survival; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Flow Cytometry; | 2000 |
beta-adrenergic receptor/cAMP-mediated signaling and apoptosis of S49 lymphoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Apo | 2000 |
Bcl-2 protects lymphoma cells from apoptosis but not growth arrest promoted by cAMP and dexamethasone.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Annexin A5; Anti-Inflammatory Agents; Apoptos | 2001 |
Real-time visualization of a fluorescent G(alpha)(s): dissociation of the activated G protein from plasma membrane.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Cells, Cultured; Cholera Toxin; Computer Systems; COS Cel | 2002 |
Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Bacterial Toxins; Binding, Competitive; Cell L | 1977 |
Isolation and characterization of S49 lymphoma cells deficient in beta-adrenergic receptors: relation of receptor number to activation of adenylate cyclase.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Clone Cells; Enzyme Activation; Isoproterenol; Lymphoma | 1979 |
Inhibitors of microtubule assembly enhance beta-adrenergic and prostaglandin E1-stimulated cyclic AMP accumulation in S49 lymphoma cells.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Cell Membrane; Colchicine; Cyclic AMP; Drug In | 1979 |
Somatic genetic analysis of cyclic AMP action: characterization of unresponsive mutants.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Bucladesine; Cell Division; Cell Line; Cyclic AMP; Drug Resista | 1975 |
Mechanism of lymphoma cell death induced by cyclic AMP.
Topics: Animals; Bucladesine; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Cholera; Cyclic AMP; | 1975 |
Relationship between the beta-adrenergic receptor and adenylate cyclase.
Topics: Adenylyl Cyclases; Bacterial Toxins; Cell Line; Cell Membrane; Enzyme Activation; Guanosine Triphosp | 1977 |
Influence of cholera toxin on the regulation of adenylate cyclase by GTP.
Topics: Adenylyl Cyclases; Binding Sites; Cell Line; Cell Membrane; Cholera Toxin; Cyclic AMP; Enzyme Activa | 1977 |
Colchicine potentiates beta-adrenoreceptor-stimulated cyclic AMP in lymphoma cells by an action distal to the receptor.
Topics: Adenylyl Cyclases; Cell Line; Colchicine; Cyclic AMP; Enzyme Activation; Isoproterenol; Lymphoma; Re | 1978 |
The agonist-specific effect of magnesium ion on binding by beta-adrenergic receptors in S49 lymphoma cells. Interaction of GTP and magnesium in adenylate cyclase activation.
Topics: Adenylyl Cyclases; Cell Line; Cell Membrane; Enzyme Activation; Fluorides; Guanosine Triphosphate; I | 1978 |
S49 lymphoma wild type and variant clones contain normal calcium dependent regulator.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Calcium; Calmodulin; Carrier Proteins; Cell | 1978 |
Temperature-dependent changes in binding to beta-adrenergic receptors of intact S49 lymphoma cells. Implications for the state of the receptor that activates adenylate cyclase under physiological conditions.
Topics: Adenylyl Cyclases; Alprenolol; Binding, Competitive; Cell Line; Cyclic AMP; Enzyme Activation; Isopr | 1979 |
A variant of S49 mouse lymphoma cells with enhanced secretion of cyclic AMP.
Topics: Animals; Bucladesine; Cell Line; Cyclic AMP; Isoproterenol; Lymphoma; Mice; Mutation; Protein Kinase | 1979 |
Adenylate cyclase assembled in vitro: cholera toxin substrates determine different patterns of regulation by isoproterenol and guanosine 5'-triphosphate.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Cholera Toxin; Erythrocyte Membrane; Fluorides; Guanine N | 1979 |
Reconstitution of catecholamine-sensitive adenylate cyclase. Reconstitution of the uncoupled variant of the S40 lymphoma cell.
Topics: Adenylyl Cyclases; Animals; Catecholamines; Cell Line; Cell Membrane; Enzyme Activation; Fibroblasts | 1979 |
Beta-adrenergic-receptor-mediated dissociation and membrane release of the Gs protein in S49 lymphoma-cell membranes. Dependence on Mg2+ and GTP.
Topics: Animals; Cell Line; Cell Membrane; Enzyme-Linked Immunosorbent Assay; GTP-Binding Proteins; Guanosin | 1992 |
Comparison of methods to assess cyclic AMP turnover under conditions of agonist stimulation in 1321N1 astrocytoma cells.
Topics: Adenine; Adenosine Triphosphate; Animals; Astrocytoma; Carbon Radioisotopes; Cell Line; Cyclic AMP; | 1992 |
Expression and function of beta-adrenergic receptors in human hematopoietic cell lines.
Topics: Blood Cells; Blotting, Southern; Cell Division; Cell Line; Cyclic AMP; DNA; DNA, Neoplasm; Humans; I | 1992 |
[Effect of eosinophil peroxidase on beta-adrenergic receptor-adenylate cyclase system].
Topics: Adenylyl Cyclases; Animals; Asthma; Cyclic AMP; Eosinophil Peroxidase; Guinea Pigs; In Vitro Techniq | 1992 |
Stoichiometry of receptor-Gs-adenylate cyclase interactions.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cholera Toxin; Colforsin; GTP-Binding Proteins; Isoproterenol | 1991 |
Abnormal guanine nucleotide regulatory protein in MVP dysautonomia: evidence from reconstitution of Gs.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Adult; Animals; Autonomic Nervous System Diseases; | 1991 |
Developmental changes in adenylyl cyclase and GTP binding proteins in brown fat.
Topics: Adenylyl Cyclases; Adipose Tissue, Brown; Animals; Animals, Newborn; Dose-Response Relationship, Dru | 1991 |
Hormone inhibition of adenylyl cyclase. Differences in the mechanisms for inhibition by hormones and G protein beta gamma.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; Colforsin; GTP-Bi | 1990 |
Beta-adrenoceptor metabolism in wild-type, Gs, and protein kinase A-variant S49 cells.
Topics: Adrenergic beta-Antagonists; Animals; Binding, Competitive; Cell Line; Clone Cells; Cyclohexane Mono | 1990 |
The beta-adrenoceptor antagonist carteolol and its metabolite 8-hydroxycarteolol have different intrinsic sympathomimetic activities.
Topics: Carteolol; Cyclic AMP; Humans; Isoproterenol; Lymphoma; Muscle, Smooth; Sympathomimetics; Tumor Cell | 1990 |
1,25-Dihydroxyvitamin D3 and adenosine 3',5'-monophosphate synergistically promote differentiation of a monocytic cell line.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Calcitriol; Cell Differentiation; Cell Line; Colforsin; Co | 1986 |
Differential [32P]-labeling of chemically induced stress proteins in S-phase mouse lymphoma cells.
Topics: Animals; Arsenic; Arsenites; Cell Nucleus; Concanavalin A; Electrophoresis, Gel, Two-Dimensional; He | 1989 |
Reconstitution of cyc- S49 membranes by in vitro translated Gs alpha. Membrane anchorage and functional implications.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Animals; Cell Membrane; Enzyme Activation; GTP-Bind | 1989 |
Homologous and heterologous regulation of the helodermin/vasoactive-intestinal-peptide response in the murine radiation leukemia-virus-induced lymphoma cell line BL/VL3.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Drug Tolerance; Enzyme Activation; Guanylyl Imidodiphosph | 1989 |
Agonist regulation of beta-adrenergic receptor mRNA. Analysis in S49 mouse lymphoma mutants.
Topics: Animals; Cell Line; Colforsin; Gene Expression Regulation; Genes; Isoproterenol; Lymphoma; Mice; Mut | 1989 |
Stimulation of beta-adrenergic receptors of S49 lymphoma cells redistributes the alpha subunit of the stimulatory G protein between cytosol and membranes.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; Cytosol; GTP-Binding Proteins; Isoproterenol; | 1989 |
Desensitization of the beta-adrenergic receptor of the S49 murine lymphoma cell: mechanism of receptor loss and recovery.
Topics: Adenylyl Cyclases; Animals; Cycloheximide; Dose-Response Relationship, Drug; Down-Regulation; Isopro | 1989 |
Chronic somatostatin treatment induces enhanced forskolin-stimulated cAMP accumulation in wild-type S49 mouse lymphoma cells but not in protein kinase-deficient mutants.
Topics: Adenylyl Cyclase Inhibitors; Animals; Colforsin; Cyclic AMP; Isoproterenol; Lymphoma; Mice; Protein | 1989 |
The beta-adrenergic receptor kinase: role in homologous desensitization in S49 lymphoma cells.
Topics: Animals; beta-Adrenergic Receptor Kinases; Cell Line; Cyclic AMP-Dependent Protein Kinases; Isoprote | 1988 |
Effects of ethanol in vitro on the beta adrenergic receptor-coupled adenylate cyclase system.
Topics: Adenylyl Cyclases; Animals; Cell Line; Dose-Response Relationship, Drug; Ethanol; GTP-Binding Protei | 1988 |
Interaction of beta-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; GTP-Binding Prote | 1988 |
Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Putative effect of C kinase on alpha s-GTP-catalytic subunit interaction.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cholera Toxin; Cyclic AMP; Drug Synergism; GTP-Binding Protei | 1985 |
Conjugates of catecholamines. 6. Synthesis and beta-adrenergic activity of N-(hydroxyalkyl)catecholamine derivatives.
Topics: Adrenergic beta-Agonists; Animals; Binding, Competitive; Catecholamines; Cyclic AMP; Hydroxylation; | 1985 |
Interactions of agonists with beta-adrenergic receptors on S49 lymphoma cells.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Albuterol; Animals; Binding, Competitive; Cell Lin | 1985 |
Expression of beta-adrenergic receptors in synchronous and asynchronous S49 lymphoma cells. I. Receptor metabolism after irreversible blockade of receptors and in cells traversing the cell division cycle.
Topics: Adrenergic beta-Antagonists; Alprenolol; Cell Cycle; Cell Division; Cell Line; Centrifugation; Human | 1986 |
Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Withdrawal of GTP-dependent inhibition.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cell Line; Chlorides; Colforsin; Cyclic AMP; Gu | 1986 |
Down regulation of beta adrenergic receptors in S49 lymphoma cells induced by atypical agonists.
Topics: Adrenergic beta-Agonists; Animals; Binding Sites; Celiprolol; Cell Division; Cell Line; Isoprotereno | 1986 |
Conjugates of catecholamines. VII. Synthesis and beta-adrenergic activity of peptide catecholamine conjugates.
Topics: Adrenergic beta-Agonists; Animals; Catecholamines; Cyclic AMP; Indicators and Reagents; Isoprotereno | 1987 |
Gi affects the agonist-binding properties of beta-adrenoceptors in the presence of Gs.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Catalysis; Cholera To | 1988 |
Molecular mechanism of beta-adrenergic receptor blockers with intrinsic sympathomimetic activity.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Celiprolol; Colforsin; Cyclic AMP; Drug Synergism; I | 1988 |
Cyclic AMP stimulates dephosphorylation of specific proteins in intact S49 mouse lymphoma cells.
Topics: Animals; Cell Line; Cyclic AMP; Isoproterenol; Lymphoma; Mice; Phosphoprotein Phosphatases; Phosphop | 1985 |
Genetic analysis of beta-adrenergic receptor internalization and down-regulation.
Topics: Animals; Cell Line; Cyclic AMP; Endocytosis; GTP-Binding Proteins; Isoproterenol; Kinetics; Lymphoma | 1985 |
beta-Adrenergic receptors and adenylate cyclase activity in murine lymphoid cell lines.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; B-Lymphocytes; Cell Line; Cell Membrane; Co | 1985 |
Homologous desensitization of beta-adrenergic receptor coupled adenylate cyclase. Resensitization by polyethylene glycol treatment.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; GTP-Binding Proteins; Guanylyl Imidodiphosphat | 1985 |
Cytosol activator protein from rat reticulocytes requires the stimulatory guanine nucleotide-binding protein for its actions on adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cytosol; Dinoprostone; Enzyme Activation; Erythrocyte Membran | 1985 |
Properties of beta-adrenergic receptors of cultured mammalian cells. Interaction of receptors with a guanine nucleotide-binding protein in membranes prepared from L6 myoblasts and from wild-type and cyc- S49 lymphoma cells.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; GTP-Binding Proteins; Isoproterenol; Kinetics; | 1985 |
Expression of beta-adrenergic receptors in synchronous and asynchronous S49 lymphoma cells. II. Relationship between receptor number and response.
Topics: Adenylyl Cyclases; Alprenolol; Cell Cycle; Cell Line; Colforsin; Cyclic AMP; GTP-Binding Proteins; G | 1986 |
A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Amino Acids; Animals; Cell Line; Cell Membrane; Cyclic AM | 1986 |
High potency congeners of isoproterenol. Binding to beta-adrenergic receptors, activation of adenylate cyclase and stimulation of intracellular cyclic AMP synthesis.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activati | 1986 |
Regulation of magnesium but not calcium transport by phorbol ester.
Topics: Animals; Biological Transport, Active; Calcium; Cell Line; Colforsin; Cyclic AMP; Isoproterenol; Kin | 1986 |
Functional expression of cloned cDNA encoding the alpha-subunit of adenylate cyclase-stimulating G-protein.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cloning, Molecular; Cyclic AMP; DNA; Genes; GTP-Binding Prote | 1987 |
Bromoacetylalprenololmenthane binding to beta-receptors modulates the rate of hormone-induced internalization but not desensitization in S49 cells.
Topics: Alprenolol; Cell Line; Cell Membrane; Cyclic AMP; Isoproterenol; Kinetics; Lymphoma; Propanolamines; | 1987 |
Multiple effects of phorbol esters on hormone-sensitive adenylate cyclase activity in S49 lymphoma cells.
Topics: Adenylyl Cyclases; Alprostadil; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; GTP-Binding Protein | 1987 |
Interactions of beta-adrenergic receptors with a membrane protein other than the stimulatory guanine nucleotide-binding protein.
Topics: Adenylyl Cyclases; Animals; Cell Line; GTP-Binding Proteins; Isoproterenol; Lymphoma; Membrane Prote | 1987 |
The inverse relationship between drug affinity and effectiveness: prediction under rate theory, paradox under occupancy theory.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Isoproterenol; Kinetics; Lymphoma; Mathematics; Mice; Mod | 1987 |
Subunit dissociation is the mechanism for hormonal activation of the Gs protein in native membranes.
Topics: Animals; Cell Line; Cell Membrane; Enzyme-Linked Immunosorbent Assay; GTP-Binding Proteins; Guanosin | 1988 |
Forskolin binding to intact S49 lymphoma cells.
Topics: Animals; Binding, Competitive; Colforsin; Cytochalasin B; Epinephrine; Isoproterenol; Ligands; Lymph | 1988 |
Reticulocyte cytosol activator protein: effects on the stimulatory and inhibitory regulatory proteins of adenylate cyclase.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Bacterial Toxins; | 1985 |
Altered metabolism and endogenous cyclic AMP in cultured cells deficient in cyclic AMP-binding proteins.
Topics: Animals; Butyrates; Cells, Cultured; Cyclic AMP; Histones; Isoproterenol; Kinetics; Leucine; Lymphom | 1973 |
Regulation of phosphodiesterase synthesis: requirement for cyclic adenosine monophosphate-dependent protein kinase.
Topics: Animals; Butyrates; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Enzyme Induction; Feedback; | 1973 |