isoproterenol has been researched along with Long QT Syndrome in 60 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The response over time of the QT interval and the Transmural Dispersion of Repolarization (TDR) to Isoproterenol infusion (ISO) in an 85 year-old-man with severe and syntomatic bradycardia, in the setting of an Amiodarone-induced Long QT Syndrome (LQTS) is the subject of this communication." | 7.75 | Isoproterenol enhancement of I(Ks) current in amiodarone-induced long QT syndrome. ( Gutierrez, J; Raviña, M; Raviña, T, 2009) |
| "A 36-year-old female was given terfenadine 120 mg/day for hay fever, and itraconazole 100 mg twice daily for mycosis." | 7.69 | [Syncopes during simultaneous use of terfenadine and itraconazole]. ( Froger, CL; Romkes, JH; Westerhof, PW; Wever, EF, 1997) |
| "A 17-year-old male with anorexia nervosa developed atypical prolongation of his corrected QT interval (QTc) when placed on isoproterenol for profound sinus bradycardia." | 7.68 | QT prolongation by isoproterenol in anorexia nervosa. ( Harris, JP; Kreipe, RE; Rossbach, CN, 1993) |
| "These results suggest that patients with congenital long QT syndrome have primary repolarization abnormalities and that EADs induced by isoproterenol play an important role in the exaggeration of these repolarization abnormalities." | 7.68 | Early afterdepolarizations induced by isoproterenol in patients with congenital long QT syndrome. ( Aihara, N; Kamakura, S; Kurita, T; Matsuhisa, M; Ohe, T; Shimizu, W; Shimomura, K; Takaki, H, 1991) |
| "Spontaneous focal arrhythmias appeared within 8-18 min following 92 microM d-sotalol in 15 of 23 hearts." | 5.31 | Modulation of arrhythmias by isoproterenol in a rabbit heart model of d-sotalol-induced long Q-T intervals. ( Moore, EN; Spear, JF, 2000) |
| " We describe a severe case of refractory TdP in the setting of methadone, cocaine, hypokalemia and hypomagnesemia." | 3.91 | Severe Torsades de Pointes with acquired QT prolongation. ( Narang, A; Ozcan, C, 2019) |
| " Here, we present a case of cryptogenic underlying congenital long QT syndrome (cLQTS) successfully treated with isoproterenol, a drug contraindicated in most congenital forms of this condition." | 3.88 | Recurrent Torsades with Refractory QT Prolongation in a 54-Year-Old Man. ( Bunin, J; Guess, J; Hubel, K; Madigan, CG; Wiggins, A, 2018) |
| "The EMw was calculated as differences between the QT interval and QLVP(end) in FEAB dogs during atrial pacing, treatment with isoprenaline or atropine, body temperature changes and induction of Torsade de Pointes (TdP) in an LQT1 model." | 3.76 | The Electro-Mechanical window: a risk marker for Torsade de Pointes in a canine model of drug induced arrhythmias. ( Gallacher, DJ; Loenders, B; Somers, Y; Towart, R; van der Linde, HJ; Van Deuren, B, 2010) |
| "The response over time of the QT interval and the Transmural Dispersion of Repolarization (TDR) to Isoproterenol infusion (ISO) in an 85 year-old-man with severe and syntomatic bradycardia, in the setting of an Amiodarone-induced Long QT Syndrome (LQTS) is the subject of this communication." | 3.75 | Isoproterenol enhancement of I(Ks) current in amiodarone-induced long QT syndrome. ( Gutierrez, J; Raviña, M; Raviña, T, 2009) |
| " Phenylephrine-induced reflex bradycardia increased QTbtb by 3 ms but decreased QTcB by 20 ms and QTcF by 12 ms." | 3.73 | Dynamic beat-to-beat modeling of the QT-RR interval relationship: analysis of QT prolongation during alterations of autonomic state versus human ether a-go-go-related gene inhibition. ( Crimin, K; Fossa, AA; Gorczyca, W; Magnano, A; Raunig, DL; Winslow, R; Wisialowski, T; Wolfgang, E, 2005) |
| "To determine whether the neonatal mouse can serve as a useful model for studying the molecular pharmacological basis of Long QT Syndrome Type 1 (LQT1), which has been linked to mutations in the human KCNQ1 gene, we measured QT intervals from electrocardiogram (ECG) recordings of wild-type (WT) and Kcnq1 knockout (KO) neonates before and after injection with the beta-adrenergic receptor agonist, isoproterenol (0." | 3.72 | Isoproterenol exacerbates a long QT phenotype in Kcnq1-deficient neonatal mice: possible roles for human-like Kcnq1 isoform 1 and slow delayed rectifier K+ current. ( Casimiro, MC; Ebert, SN; Katchman, AN; Knollmann, BC; Pfeifer, K; Rong, Q; Schober, T; Sirenko, SG, 2004) |
| " In our preliminary result of patients with Brugada syndrome including a child, isoproterenol infusion was effective to decrease the ST-segment elevation in leads V1-V2 and to suppress the electrical storm of ventricular fibrillation." | 3.71 | Catecholamines in children with congenital long QT syndrome and Brugada syndrome. ( Kamakura, S; Shimizu, W, 2001) |
| "This study examines the effects of nicorandil, a K(+) channel opener, on transmural dispersion of repolarization (TDR) and induction of torsade de pointes (TdP) under conditions mimicking the LQT1, LQT2, and LQT3 forms of the congenital long-QT syndrome (LQTS)." | 3.70 | Effects of a K(+) channel opener to reduce transmural dispersion of repolarization and prevent torsade de pointes in LQT1, LQT2, and LQT3 models of the long-QT syndrome. ( Antzelevitch, C; Shimizu, W, 2000) |
| "A 36-year-old female was given terfenadine 120 mg/day for hay fever, and itraconazole 100 mg twice daily for mycosis." | 3.69 | [Syncopes during simultaneous use of terfenadine and itraconazole]. ( Froger, CL; Romkes, JH; Westerhof, PW; Wever, EF, 1997) |
| "A 17-year-old male with anorexia nervosa developed atypical prolongation of his corrected QT interval (QTc) when placed on isoproterenol for profound sinus bradycardia." | 3.68 | QT prolongation by isoproterenol in anorexia nervosa. ( Harris, JP; Kreipe, RE; Rossbach, CN, 1993) |
| "These results suggest that patients with congenital long QT syndrome have primary repolarization abnormalities and that EADs induced by isoproterenol play an important role in the exaggeration of these repolarization abnormalities." | 3.68 | Early afterdepolarizations induced by isoproterenol in patients with congenital long QT syndrome. ( Aihara, N; Kamakura, S; Kurita, T; Matsuhisa, M; Ohe, T; Shimizu, W; Shimomura, K; Takaki, H, 1991) |
| "AV block was created in dogs to induce ventricular remodeling, including enhanced susceptibility to dofetilide-induced torsades de pointes arrhythmias." | 1.38 | Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog. ( Antoons, G; Beekman, JD; Bourgonje, VJ; de Windt, LJ; Houtman, MJ; Miedema, LF; Schoenmakers, M; Sipido, K; van der Nagel, R; van Veen, TA; Vos, MA, 2012) |
| "Spontaneous focal arrhythmias appeared within 8-18 min following 92 microM d-sotalol in 15 of 23 hearts." | 1.31 | Modulation of arrhythmias by isoproterenol in a rabbit heart model of d-sotalol-induced long Q-T intervals. ( Moore, EN; Spear, JF, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (31.67) | 18.2507 |
| 2000's | 24 (40.00) | 29.6817 |
| 2010's | 15 (25.00) | 24.3611 |
| 2020's | 2 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Wåström, M | 1 |
| Pfammatter, JP | 1 |
| Merino, JL | 1 |
| Martínez-Cossiani, M | 1 |
| Iniesta, A | 1 |
| Escobar, C | 1 |
| Rey, JR | 1 |
| Castrejón-Castrejón, S | 1 |
| Li, G | 1 |
| Wang, J | 1 |
| Liao, P | 1 |
| Bartels, P | 1 |
| Zhang, H | 1 |
| Yu, D | 1 |
| Liang, MC | 1 |
| Poh, KK | 1 |
| Yu, CY | 1 |
| Jiang, F | 1 |
| Yong, TF | 1 |
| Wong, YP | 1 |
| Hu, Z | 1 |
| Huang, H | 1 |
| Zhang, G | 1 |
| Galupo, MJ | 1 |
| Bian, JS | 1 |
| Ponniah, S | 1 |
| Trasti, SL | 1 |
| See, K | 1 |
| Foo, R | 1 |
| Hoppe, UC | 1 |
| Herzig, S | 1 |
| Soong, TW | 1 |
| Guess, J | 1 |
| Hubel, K | 1 |
| Wiggins, A | 1 |
| Madigan, CG | 1 |
| Bunin, J | 1 |
| Biet, M | 1 |
| Ton, AT | 1 |
| Delabre, JF | 1 |
| Morin, N | 1 |
| Dumaine, R | 1 |
| Narang, A | 1 |
| Ozcan, C | 1 |
| Huang, X | 1 |
| Kim, TY | 1 |
| Koren, G | 3 |
| Choi, BR | 4 |
| Qu, Z | 2 |
| Ahrens-Nicklas, RC | 1 |
| Clancy, CE | 2 |
| Christini, DJ | 1 |
| Takaya, T | 1 |
| Okamoto, M | 1 |
| Yodoi, K | 1 |
| Hata, K | 1 |
| Kijima, Y | 1 |
| Nakajima, H | 1 |
| Nishikawa, Y | 1 |
| Kita, T | 1 |
| Ito, M | 1 |
| Seo, T | 1 |
| Kawashima, S | 1 |
| Odening, KE | 1 |
| Kirk, M | 1 |
| Brunner, M | 1 |
| Ziv, O | 2 |
| Lorvidhaya, P | 1 |
| Liu, GX | 2 |
| Schofield, L | 1 |
| Chaves, L | 1 |
| Peng, X | 1 |
| Zehender, M | 1 |
| van der Linde, HJ | 1 |
| Van Deuren, B | 1 |
| Somers, Y | 1 |
| Loenders, B | 1 |
| Towart, R | 2 |
| Gallacher, DJ | 2 |
| Matsa, E | 1 |
| Rajamohan, D | 1 |
| Dick, E | 1 |
| Young, L | 1 |
| Mellor, I | 1 |
| Staniforth, A | 1 |
| Denning, C | 1 |
| Komarlu, R | 1 |
| Beerman, L | 1 |
| Freeman, D | 1 |
| Arora, G | 1 |
| Nissen, JD | 1 |
| Thomsen, MB | 1 |
| Bentzen, BH | 1 |
| Diness, JG | 1 |
| Diness, TG | 1 |
| Jespersen, T | 1 |
| Grunnet, M | 1 |
| Li, W | 1 |
| de Lange, E | 1 |
| Vahedi, F | 1 |
| Odenstedt, J | 1 |
| Hartford, M | 1 |
| Gilljam, T | 1 |
| Bergfeldt, L | 1 |
| Petric, S | 1 |
| Clasen, L | 1 |
| van Wessel, C | 1 |
| Geduldig, N | 1 |
| Ding, Z | 1 |
| Schullenberg, M | 1 |
| Mersmann, J | 1 |
| Zacharowski, K | 1 |
| Aller, MI | 1 |
| Schmidt, KG | 1 |
| Donner, BC | 1 |
| Bourgonje, VJ | 1 |
| Schoenmakers, M | 1 |
| Beekman, JD | 1 |
| van der Nagel, R | 1 |
| Houtman, MJ | 1 |
| Miedema, LF | 1 |
| Antoons, G | 1 |
| Sipido, K | 1 |
| de Windt, LJ | 1 |
| van Veen, TA | 1 |
| Vos, MA | 2 |
| Maruyama, M | 1 |
| Xiao, J | 1 |
| Zhou, Q | 1 |
| Vembaiyan, K | 1 |
| Chua, SK | 1 |
| Rubart-von der Lohe, M | 1 |
| Lin, SF | 1 |
| Back, TG | 1 |
| Chen, SR | 1 |
| Chen, PS | 1 |
| Shimizu, W | 9 |
| Knollmann, BC | 1 |
| Casimiro, MC | 1 |
| Katchman, AN | 1 |
| Sirenko, SG | 1 |
| Schober, T | 1 |
| Rong, Q | 1 |
| Pfeifer, K | 1 |
| Ebert, SN | 1 |
| Fossa, AA | 1 |
| Wisialowski, T | 1 |
| Magnano, A | 1 |
| Wolfgang, E | 1 |
| Winslow, R | 1 |
| Gorczyca, W | 1 |
| Crimin, K | 1 |
| Raunig, DL | 1 |
| Saucerman, JJ | 1 |
| Healy, SN | 1 |
| Belik, ME | 1 |
| Puglisi, JL | 1 |
| McCulloch, AD | 1 |
| Nakagawa, M | 1 |
| Ooie, T | 1 |
| Ou, B | 1 |
| Ichinose, M | 1 |
| Takahashi, N | 1 |
| Hara, M | 1 |
| Yonemochi, H | 1 |
| Saikawa, T | 1 |
| Viskin, S | 1 |
| Liu, T | 1 |
| Drici, MD | 2 |
| Salama, G | 1 |
| Magnano, AR | 1 |
| Talathoti, N | 1 |
| Hallur, R | 1 |
| Bloomfield, DM | 1 |
| Garan, H | 1 |
| Fitzgerald, DM | 1 |
| Suto, F | 1 |
| Zhu, W | 1 |
| Chan, A | 1 |
| Gross, GJ | 1 |
| Barnay, C | 1 |
| Taieb, J | 1 |
| Morice, R | 1 |
| Jouve, B | 1 |
| Rahal, Y | 1 |
| Benchaa, T | 1 |
| Alfares, A | 1 |
| Lenaers, C | 1 |
| Boulain, L | 1 |
| Pizigo, E | 1 |
| Van de Water, A | 1 |
| van der Linde, H | 1 |
| Hermans, AN | 1 |
| Lu, HR | 1 |
| Volders, PG | 1 |
| Fabritz, L | 1 |
| Raviña, T | 1 |
| Raviña, M | 1 |
| Gutierrez, J | 1 |
| Kawade, M | 1 |
| Ohe, T | 5 |
| Kamiya, T | 2 |
| Harris, JP | 1 |
| Kreipe, RE | 1 |
| Rossbach, CN | 1 |
| Mei, KZ | 1 |
| Sun, AH | 1 |
| Li, BJ | 1 |
| Priori, SG | 1 |
| Napolitano, C | 1 |
| Cantù, F | 1 |
| Brown, AM | 1 |
| Schwartz, PJ | 1 |
| Katagiri-Kawade, M | 1 |
| Arakaki, Y | 1 |
| Kurita, T | 4 |
| Orii, T | 1 |
| Balaji, S | 1 |
| Lau, YR | 1 |
| Gillette, PC | 1 |
| Romkes, JH | 1 |
| Froger, CL | 1 |
| Wever, EF | 1 |
| Westerhof, PW | 1 |
| Arrighi, I | 1 |
| Chouabe, C | 1 |
| Mann, JR | 1 |
| Lazdunski, M | 1 |
| Romey, G | 1 |
| Barhanin, J | 1 |
| Antzelevitch, C | 4 |
| Kantoch, MJ | 1 |
| Qurashi, MM | 1 |
| Bulbul, ZR | 1 |
| Gorgels, AP | 1 |
| Kupershmidt, S | 1 |
| Yang, T | 1 |
| Anderson, ME | 1 |
| Wessels, A | 1 |
| Niswender, KD | 1 |
| Magnuson, MA | 1 |
| Roden, DM | 1 |
| Chandra, R | 1 |
| Chauhan, VS | 1 |
| Starmer, CF | 1 |
| Grant, AO | 1 |
| Liu, YB | 1 |
| Chen, WJ | 1 |
| Lee, YT | 1 |
| Spear, JF | 1 |
| Moore, EN | 1 |
| Han, W | 1 |
| Wang, Z | 1 |
| Nattel, S | 1 |
| Nuyens, D | 1 |
| Stengl, M | 1 |
| Dugarmaa, S | 1 |
| Rossenbacker, T | 1 |
| Compernolle, V | 1 |
| Rudy, Y | 1 |
| Smits, JF | 1 |
| Flameng, W | 1 |
| Moons, L | 1 |
| Dewerchin, M | 1 |
| Benndorf, K | 1 |
| Collen, D | 1 |
| Carmeliet, E | 1 |
| Carmeliet, P | 1 |
| Khan, IA | 1 |
| Kamakura, S | 3 |
| Nakayama, T | 1 |
| Shimada, K | 1 |
| Inoue, H | 1 |
| Sugimoto, T | 1 |
| Takaki, H | 1 |
| Aihara, N | 2 |
| Matsuhisa, M | 2 |
| Shimomura, K | 3 |
| Sakurada, H | 1 |
| Tejima, T | 1 |
| Hiyoshi, Y | 1 |
| Motomiya, T | 1 |
| Hiraoka, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Electromechanical Profiling of Arrhythmogenic Substrates and Triggers in the Long-QT Syndrome[NCT04074122] | 150 participants (Anticipated) | Observational | 2020-01-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for isoproterenol and Long QT Syndrome
| Article | Year |
|---|---|
Effects of sympathetic stimulation on various repolarization indices in the congenital long QT syndrome.
Topics: Electrocardiography; Epinephrine; Heart Rate; Humans; Isoproterenol; Long QT Syndrome; Models, Biolo | 2002 |
[Acquired long QT syndrome: a dominant problem?].
Topics: Adrenergic beta-Agonists; Drug Therapy, Combination; Electric Countershock; Electrocardiography; Hum | 2006 |
Long QT syndrome: diagnosis and management.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Cardiac Pacing, Artificial; Cardi | 2002 |
57 other studies available for isoproterenol and Long QT Syndrome
| Article | Year |
|---|---|
Ten-year-old boy with congenital long QT syndrome type 2 (LQTS2) and life-threatening electrical storm: a case report of successful treatment with mexiletine.
Topics: Arrhythmias, Cardiac; Humans; Isoproterenol; Long QT Syndrome; Male; Mexiletine; Ventricular Fibrill | 2022 |
COVID-19 and QT interval prolongation: more than just drug toxicity?
Topics: Adrenergic beta-Agonists; Aged; Anti-Infective Agents; Azithromycin; Betacoronavirus; Clinical Labor | 2020 |
Exclusion of alternative exon 33 of Ca
Topics: Action Potentials; Alternative Splicing; Animals; Calcium Channel Blockers; Calcium Channels, L-Type | 2017 |
Recurrent Torsades with Refractory QT Prolongation in a 54-Year-Old Man.
Topics: Cardiotonic Agents; Electrocardiography; Humans; Isoproterenol; KCNQ1 Potassium Channel; Long QT Syn | 2018 |
In utero exposure to nicotine abolishes the postnatal response of the cardiac sodium current to isoproterenol in newborn rabbit atrium.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Animals, Newborn; Disease Models, Animal; Fema | 2019 |
Severe Torsades de Pointes with acquired QT prolongation.
Topics: Administration, Intravenous; Anti-Arrhythmia Agents; Benzodiazepines; Chest Pain; Cocaine; Echocardi | 2019 |
Spontaneous initiation of premature ventricular complexes and arrhythmias in type 2 long QT syndrome.
Topics: Adrenergic beta-Agonists; Animals; Animals, Genetically Modified; Arrhythmias, Cardiac; Calcium; Com | 2016 |
Re-evaluating the efficacy of beta-adrenergic agonists and antagonists in long QT-3 syndrome through computational modelling.
Topics: Action Potentials; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Computer Simulati | 2009 |
Torsades de Pointes with QT prolongation related to donepezil use.
Topics: Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Colitis; Donepezil; Electrocardiogr | 2009 |
Electrophysiological studies of transgenic long QT type 1 and type 2 rabbits reveal genotype-specific differences in ventricular refractoriness and His conduction.
Topics: Action Potentials; Animals; Animals, Genetically Modified; Atrioventricular Block; Atrioventricular | 2010 |
The Electro-Mechanical window: a risk marker for Torsade de Pointes in a canine model of drug induced arrhythmias.
Topics: Adrenergic beta-Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atropine; Body Temp | 2010 |
Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation.
Topics: Adolescent; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Calcium C | 2011 |
Fetal and neonatal presentation of long QT syndrome.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Electrocardiography; ERG1 Potassium Channel; Et | 2012 |
Attenuated ventricular β-adrenergic response and reduced repolarization reserve in a rabbit model of chronic heart failure.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Cardiac Pacing, Artificial; Chronic Disease; D | 2012 |
Differential conditions for early after-depolarizations and triggered activity in cardiomyocytes derived from transgenic LQT1 and LQT2 rabbits.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Animals, Genetically Modified; Calcium; Comput | 2012 |
Vectorcardiography analysis of the repolarization response to pharmacologically induced autonomic nervous system modulation in healthy subjects.
Topics: Adaptation, Physiological; Adult; Atropine; Autonomic Nervous System; Body Mass Index; Female; Heart | 2012 |
In vivo electrophysiological characterization of TASK-1 deficient mice.
Topics: Adrenergic beta-Agonists; Anesthetics; Animals; Atrial Function; Baroreflex; Electric Stimulation; E | 2012 |
Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog.
Topics: Animals; Arrhythmias, Cardiac; Atrioventricular Block; Benzylamines; Calcineurin; Calcium-Binding Pr | 2012 |
Carvedilol analogue inhibits triggered activities evoked by both early and delayed afterdepolarizations.
Topics: Action Potentials; Analysis of Variance; Animals; Calcium; Carbazoles; Carvedilol; Heart Ventricles; | 2013 |
Isoproterenol exacerbates a long QT phenotype in Kcnq1-deficient neonatal mice: possible roles for human-like Kcnq1 isoform 1 and slow delayed rectifier K+ current.
Topics: Action Potentials; Adrenergic beta-Agonists; Amino Acid Sequence; Animals; Delayed Rectifier Potassi | 2004 |
Dynamic beat-to-beat modeling of the QT-RR interval relationship: analysis of QT prolongation during alterations of autonomic state versus human ether a-go-go-related gene inhibition.
Topics: Adrenergic beta-Agonists; Animals; Bradycardia; Dogs; ERG1 Potassium Channel; Ether-A-Go-Go Potassiu | 2005 |
Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue.
Topics: Action Potentials; Adaptor Proteins, Signal Transducing; Adrenergic beta-1 Receptor Agonists; Amino | 2004 |
Gender differences in autonomic modulation of ventricular repolarization in humans.
Topics: Adult; Atropine; Autonomic Nervous System; Disease Susceptibility; Electrophysiologic Techniques, Ca | 2005 |
Drug challenge with epinephrine or isoproterenol for diagnosing a long QT syndrome: should we try this at home?
Topics: Electrophysiologic Techniques, Cardiac; Epinephrine; Humans; Isoproterenol; Long QT Syndrome; Ventri | 2005 |
Sex modulates the arrhythmogenic substrate in prepubertal rabbit hearts with Long QT 2.
Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Fe | 2005 |
Sympathomimetic infusion and cardiac repolarization: the normative effects of epinephrine and isoproterenol in healthy subjects.
Topics: Adult; Electrocardiography; Epinephrine; Female; Heart Rate; Humans; Infusions, Intravenous; Isoprot | 2006 |
The normal effects of epinephrine and isoproterenol on heart rate and QT interval: role in unmasking the long QT syndrome.
Topics: Epinephrine; Heart Rate; Humans; Isoproterenol; Long QT Syndrome | 2006 |
IKr and IKs remodeling differentially affects QT interval prolongation and dynamic adaptation to heart rate acceleration in bradycardic rabbits.
Topics: Adaptation, Physiological; Adrenergic beta-Agonists; Animals; Bradycardia; Down-Regulation; Heart Bl | 2007 |
In vivo mechanisms precipitating torsades de pointes in a canine model of drug-induced long-QT1 syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium; Chromans; Disease Models, Animal; Dogs; | 2007 |
Drug-induced torsades de pointes--a form of mechano-electric feedback?
Topics: Action Potentials; Animals; Disease Models, Animal; Dogs; Electrocardiography; Feedback, Physiologic | 2007 |
Isoproterenol enhancement of I(Ks) current in amiodarone-induced long QT syndrome.
Topics: Aged, 80 and over; Amiodarone; Dose-Response Relationship, Drug; Humans; Isoproterenol; Long QT Synd | 2009 |
Provocative testing and drug response in a patient with the long QT syndrome.
Topics: Adolescent; Drug Therapy, Combination; Electrocardiography; Epinephrine; Female; Humans; Isoproteren | 1995 |
QT prolongation by isoproterenol in anorexia nervosa.
Topics: Adolescent; Anorexia Nervosa; Depressive Disorder; Electrocardiography; Heart Rate; Humans; Infusion | 1993 |
[Classification and treatment of torsades de pointes (TdP): a report of 11 cases].
Topics: Aged; Female; Heart Block; Humans; Hypokalemia; Isoproterenol; Long QT Syndrome; Magnesium Sulfate; | 1993 |
Differential response to Na+ channel blockade, beta-adrenergic stimulation, and rapid pacing in a cellular model mimicking the SCN5A and HERG defects present in the long-QT syndrome.
Topics: Action Potentials; Animals; Cardiac Pacing, Artificial; Cation Transport Proteins; Ether-A-Go-Go Pot | 1996 |
Abnormal response to exercise, face immersion, and isoproterenol in children with the long QT syndrome.
Topics: Adolescent; Arousal; Child; Electrocardiography; Exercise Test; Female; Heart Rate; Humans; Immersio | 1995 |
Effect of heart rate on QT interval in children and adolescents.
Topics: Adolescent; Adult; Cardiac Pacing, Artificial; Cardiotonic Agents; Child; Electrocardiography; Femal | 1997 |
[Syncopes during simultaneous use of terfenadine and itraconazole].
Topics: Adult; Anti-Allergic Agents; Antifungal Agents; Cardiotonic Agents; Female; Humans; Isoproterenol; I | 1997 |
Involvement of IsK-associated K+ channel in heart rate control of repolarization in a murine engineered model of Jervell and Lange-Nielsen syndrome.
Topics: Aging; Animals; Blotting, Northern; Cardiotonic Agents; Cells, Cultured; Disease Models, Animal; Ele | 1998 |
Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: effects of beta-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Dogs; Dose-R | 1998 |
A newborn with a complex congenital heart disease, atrioventricular block, and torsade de pointes ventricular tachycardia.
Topics: Cisapride; Electrocardiography; Female; Heart Block; Heart Defects, Congenital; Humans; Infant, Newb | 1998 |
Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system.
Topics: Animals; Animals, Newborn; beta-Galactosidase; Cardiotonic Agents; Electrocardiography; Gene Express | 1999 |
beta-Adrenergic action on wild-type and KPQ mutant human cardiac Na+ channels: shift in gating but no change in Ca2+:Na+ selectivity.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Agonists; Calcium Channels; Cell Line; Human | 1999 |
Differential response of transmural dispersion of repolarization and torsade de pointes to beta-adrenergic agonists and antagonists in three models of the long QT syndrome.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Electrocardiography; Humans; Ion Cha | 1999 |
Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome.
Topics: Action Potentials; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiotonic Agent | 2000 |
Apparent ventricular bigeminy in the congenital long QT syndrome: what is the mechanism?
Topics: Action Potentials; Adrenergic beta-Agonists; Adult; Diagnosis, Differential; Electrocardiography; Fe | 2000 |
Modulation of arrhythmias by isoproterenol in a rabbit heart model of d-sotalol-induced long Q-T intervals.
Topics: Action Potentials; Analysis of Variance; Animals; Arrhythmias, Cardiac; Blood Pressure; Electrocardi | 2000 |
Effects of a K(+) channel opener to reduce transmural dispersion of repolarization and prevent torsade de pointes in LQT1, LQT2, and LQT3 models of the long-QT syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Chromans; Cnidarian Venoms; | 2000 |
Slow delayed rectifier current and repolarization in canine cardiac Purkinje cells.
Topics: Acetamides; Action Potentials; Adrenergic beta-Agonists; Animals; Anti-Arrhythmia Agents; Benzodiaze | 2001 |
Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome.
Topics: Adrenergic beta-Agonists; Animals; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Electrocardiogr | 2001 |
Catecholamines in children with congenital long QT syndrome and Brugada syndrome.
Topics: Catecholamines; Child; Humans; Isoproterenol; Long QT Syndrome; Ventricular Fibrillation | 2001 |
[Modulation of the transient outward current by beta-receptor].
Topics: Action Potentials; Adult; Animals; Atropine; Computer Simulation; Dogs; Electrocardiography; Heart C | 1992 |
Torsades de pointes and ventricular fibrillation in a canine model of quinidine-induced QT prolongation.
Topics: Animals; Bretylium Tosylate; Cardiac Pacing, Artificial; Dogs; Female; Heart Conduction System; Isop | 1992 |
Early afterdepolarizations induced by isoproterenol in patients with congenital long QT syndrome.
Topics: Action Potentials; Adult; Blood Pressure; Cardiac Pacing, Artificial; Electrocardiography; Female; H | 1991 |
Association of humps on monophasic action potentials and ST-T alternans in a patient with Romano-Ward syndrome.
Topics: Action Potentials; Adult; Cardiac Pacing, Artificial; Electrocardiography; Electrophysiology; Female | 1991 |
Differential response of QTU interval to exercise, isoproterenol, and atrial pacing in patients with congenital long QT syndrome.
Topics: Adult; Cardiac Pacing, Artificial; Electrocardiography; Exercise; Exercise Test; Female; Heart Condu | 1991 |
Electrocardiographic and electrophysiologic studies in patients with torsades de pointe--role of monophasic action potentials.
Topics: Action Potentials; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Bradycardia; | 1990 |