isoproterenol has been researched along with Intraocular Pressure in 95 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Intraocular Pressure: The pressure of the fluids in the eye.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Interaction between topical isoprenaline and timolol on intraocular pressure was studied in conscious rabbits through changes of the dose-response curves." | 7.68 | Evidence for a synergistic interaction between isoprenaline and timolol on intraocular pressure in conscious rabbits. ( Garrido, M; Martinez de Ibarreta, MJ; Pablo, V; Santafe, J; Segarra, J, 1993) |
| "5 micrograms of timolol antagonised isoproterenol-induced ocular hypotension significantly more than timolol eyedrops (0." | 7.68 | Intraocular pressure reduction and systemic absorption of timolol after administration of one side-coated inserts in rabbits. ( Cappanera, L; Chetoni, P; Conte, U; Finne, U; Järvinen, K; Saettone, MF; Salivirta, J; Urtti, A, 1993) |
| "The effect of timolol, propranolol, epinephrine, and isoproterenol on intraocular pressure (IOP) (measured by tonometry) were compared after topical administration in conscious rabbits." | 7.65 | Comparison of the effects of timolol and other adrenergic agents on intraocular pressure in the rabbit. ( Le Douarec, JC; Plazonnet, B; Sears, ML; Silverstone, D; Stone, CA; Vareilles, P, 1977) |
| "D-isoproterenol d-bitartrate applied topically lowers intraocular pressure (IOP) in normal albino rabbits and rabbits with alpha-chymotrypsin-induced glaucoma." | 7.65 | The effect of d-isoproterenol on intraocular pressure of the rabbit, monkey, and man. ( Bausher, LP; Kass, MA; Neufeld, AH; Reid, TW; Sears, ML, 1976) |
| " beta-Blockade was evaluated by displacement of the bronchodilator (specific airway conductance), positive chronotropic (heart rate), and tremorogenic (finger tremor amplitude) dose-response curve for inhaled isoproterenol." | 5.07 | Assessment of systemic effects of different ophthalmic beta-blockers in healthy volunteers. ( Bauer, K; Binkowitz, B; Brunner-Ferber, F; Distlerath, LM; Kaik, G; Lippa, EA; Till, P, 1991) |
| "The effects of beta-adrenergic agonists isoprenaline, fenoterol and clenbuterol on the activity of adenylyl cyclase from ciliary processes and on intraocular pressure were examined in pigmented rabbits." | 3.70 | The effects of adrenergic agonists on intraocular pressure and on adenylyl cyclase activity of ciliary processes in pigmented rabbits. ( Cepelík, J; Dedina, M; Hynie, S, 1998) |
| "The intent of this work was to examine the actions of allicin on 1) intraocular pressure (IOP) in normal and unilaterally sympathectomized (SX) rabbits; 2) cAMP accumulation in the rabbit iris-ciliary body (ICB) and cultured nonpigmented epithelial (NPE) ciliary body cells; and 3) 3H-norepinephrine (NE) release by calculating fractional tritium overflow in response to electrical field stimulation (EFS, 5 Hz, 12 V/cm) in isolated, perfused rabbit ICBs." | 3.68 | Allicin-induced hypotension in rabbit eyes. ( Chu, TC; Han, JC; Ogidigben, M; Potter, DE, 1993) |
| " Interaction between topical isoprenaline and timolol on intraocular pressure was studied in conscious rabbits through changes of the dose-response curves." | 3.68 | Evidence for a synergistic interaction between isoprenaline and timolol on intraocular pressure in conscious rabbits. ( Garrido, M; Martinez de Ibarreta, MJ; Pablo, V; Santafe, J; Segarra, J, 1993) |
| "The effects of pertussis toxin on the intraocular pressure (IOP) lowering effect of clonidine and isoproterenol as well as on the inhibitory effects of clonidine and neuropeptide Y on adenylate cyclase activity of ciliary processes were studied in albino rabbits." | 3.68 | Effects of pertussis toxin on intraocular pressure and adenylate cyclase activity of ciliary processes in rabbits. ( Cepelík, J; Hynie, S, 1993) |
| "5 micrograms of timolol antagonised isoproterenol-induced ocular hypotension significantly more than timolol eyedrops (0." | 3.68 | Intraocular pressure reduction and systemic absorption of timolol after administration of one side-coated inserts in rabbits. ( Cappanera, L; Chetoni, P; Conte, U; Finne, U; Järvinen, K; Saettone, MF; Salivirta, J; Urtti, A, 1993) |
| "Isobutylmethylxanthine (IBMX), a phosphodiesterase/adenosine receptor inhibitor, was combined with norepinephrine (nE), epinephrine (Epi) and isoproterenol, respectively, to evaluate their effect on intraocular pressure (IOP)." | 3.68 | Isobutylmethylxanthine enhances adrenergic-induced ocular hypotension in rabbits and beagles. ( Busch, MJ; Groeneboer, MC; Hoyng, PF, 1991) |
| "Griseolic acid-ester (GA-ester), one of the strongest cAMP phosphodiesterase inhibitors, was combined with isoproterenol and timolol in this study to evaluate the effect on intraocular pressure (IOP)." | 3.68 | [Changes in ocular hypotensive effect of griseolic acid with isoproterenol, timolol and melanin]. ( Kiuchi, Y, 1990) |
| " When applied topically, S-32-468 was more effective than timolol in decreasing intraocular pressure in normal albino rabbits." | 3.67 | Biochemical and physiological effects of S-32-468, a beta-adrenoceptor antagonist with possible oculoselectivity. ( Nathanson, JA, 1985) |
| "The decrease in intraocular pressure elicited by isoproterenol in ocular normotensive animals is widely recognized." | 3.67 | Pharmacological characterization of beta-adrenoceptor subtype involvement in the ocular hypotensive response to beta-adrenergic stimulation. ( Chen, J; Padillo, E; Ruiz, G; Woodward, DF, 1986) |
| "The relationship between intraocular pressure (IOP) and arterial blood pressure (BP) was analyzed in response to two pressor agents (norepinephrine and angiotensin II) and two depressor agents (methacholine and isoproterenol) in pentobarbital anesthetized cats." | 3.67 | Systemic blood pressure and intraocular pressure relationship. ( Gherezghiher, T; Hey, JA; Koss, MC, 1988) |
| " We tested the d- and l-isomers of epinephrine (alpha, beta 1, beta 2), norepinephrine (alpha, beta 1), phenylephrine (alpha 1), isoproterenol (beta 1, beta 2) and soterenol (alpha, beta 2) for their comparative effects after topical administration on intraocular pressure (IOP), pupil diameter (PD), arterial blood pressure (ABP) (after both topical and i." | 3.66 | Steric structure activity relationships of various adrenergic agonists: ocular and systemic effects. ( Potter, DE; Rowland, JM, 1981) |
| "We have extended our previous observations on the effect of tranylcypromine (TCP) on intraocular pressure (IOP), following topical administration of catecholamines is normal and chemically denervated rabbit eyes." | 3.66 | Does prostacyclin mediate alpha-adrenergic induced hypotension? ( Haddeman, E; Hoyng, PF; van Alphen, GW, 1982) |
| "The effect of timolol, propranolol, epinephrine, and isoproterenol on intraocular pressure (IOP) (measured by tonometry) were compared after topical administration in conscious rabbits." | 3.65 | Comparison of the effects of timolol and other adrenergic agents on intraocular pressure in the rabbit. ( Le Douarec, JC; Plazonnet, B; Sears, ML; Silverstone, D; Stone, CA; Vareilles, P, 1977) |
| "Systemically-administered noradrenaline lowers intraocular pressure; isoproterenol, similarly administered, has an intraocular pressure-raising effect." | 3.65 | Adrenergic activity and intraocular pressure. ( Neetens, A, 1977) |
| "D-isoproterenol d-bitartrate applied topically lowers intraocular pressure (IOP) in normal albino rabbits and rabbits with alpha-chymotrypsin-induced glaucoma." | 3.65 | The effect of d-isoproterenol on intraocular pressure of the rabbit, monkey, and man. ( Bausher, LP; Kass, MA; Neufeld, AH; Reid, TW; Sears, ML, 1976) |
| "Topical administration of Isoproterenol reduces the intraocular pressure in glaucomatous eyes, but produces systemic side-effects (tachycardia arterial hypotension) that make its clinical use unadvisable." | 3.65 | [On the possibility of reducing systemic side-effects of isoproterenol eyedrops by means of topical propranolol (author's transl)]. ( Bucci, MG; Pescosolido, N, 1977) |
| "d-Isoproterenol (ISO) applied topically to the rabbit eye specifically lowered intraocular pressure." | 3.65 | Specific hypotensive and antihypertensive ocular effects of d-isoproterenol in rabbits. ( Dungan, KW; Hickey, TE; Seidehamel, RJ, 1975) |
| " Intravitreous injection of phentolamine was without effect on the intraocular pressure and resistance to outflow of aqueous humour, although such injections resulted in miosis." | 3.64 | THE ACTION OF SYMPATHOMIMETIC AMINES ON THE OUTFLOW OF AQUEOUS HUMOUR FROM THE EYE. ( EAKINS, KE; RYAN, SJ, 1964) |
| "Intraocular pressure was measured by pneumatonometry." | 1.30 | Repeated topical administration of fenoterol in rabbit reverses its initial ocular hypotensive effect and decreases sensitivity of adenylyl cyclase in ciliary processes to stimulatory agents. ( Cepelík, J; Hynie, S, 1997) |
| "Intraocular pressure was measured in ocular hypertonic rabbits which were induced by infusing 20% NaCl or 5% glucose solution." | 1.30 | Ocular hypotensive and vasodilative effects of two beta-adrenergic blockers with intrinsic sympathomimetic activity. ( Chen, IJ; Hong, SJ; Wu, KY, 1998) |
| " The dosage forms were tested on intraocular hypertensive-induced rabbits." | 1.29 | Poly(epsilon-caprolactone) nanocapsules in carteolol ophthalmic delivery. ( Hoffman, M; Maincent, P; Marchal-Heussler, L; Sirbat, D, 1993) |
| "Detomidine was found to be a partial agonist producing about 43% of maximum inhibition obtained by medetomidine." | 1.28 | Ocular hypotensive effects of medetomidine and its analogs. ( Elko, EE; Jin, Y; Wilson, S; Yorio, T, 1991) |
| " Furthermore, dose-response studies, using direct systemic administration of the two beta-adrenoceptor antagonists, revealed that ICI 118,551 is about 60 times less potent than timolol in blocking isoprenaline-induced cardio-acceleration." | 1.27 | ICI 118,551: an effective ocular hypotensive agent with selectivity for the ciliary process beta 2-adrenoceptor and with minimal cardiac side effects. ( Nathanson, JA, 1984) |
| "Isoproterenol was applied topically to one eye of each of 20 normal human volunteers." | 1.27 | The effect of isoproterenol on aqueous humor formation in humans. ( Brubaker, RF; Gaasterland, D, 1984) |
| "Metipranolol (Betamann) is a clinically efficacious ocular hypotensive drug and preclinical experiments were undertaken to characterize this beta-adrenoceptor antagonist." | 1.27 | A study on the ocular and extraocular pharmacology of metipranolol. ( Armstrong, JM; Gautheron, P; Mallorga, P; Sugrue, MF; Viader, MP, 1985) |
| "Labetalol has a unique and profound effect on the IOP of rabbits, in contrast to pure beta-adrenergic blockers which have little or no effect in this animal." | 1.26 | Ocular hypotensive action of labetalol. ( Leopold, IH; Murray, DL, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 75 (78.95) | 18.7374 |
| 1990's | 17 (17.89) | 18.2507 |
| 2000's | 2 (2.11) | 29.6817 |
| 2010's | 1 (1.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hudson, BD | 1 |
| Kelly, ME | 1 |
| EAKINS, KE | 1 |
| RYAN, SJ | 1 |
| BONOMI, L | 2 |
| THOMAS, RP | 1 |
| RILEY, MW | 1 |
| GNAEDINGER, MC | 1 |
| BARANY, EH | 1 |
| Waitzman, MB | 2 |
| King, CD | 1 |
| Rowland, JM | 3 |
| Potter, DE | 6 |
| Bartels, SP | 1 |
| Roth, HO | 1 |
| Jumblatt, MM | 1 |
| Neufeld, AH | 5 |
| Morgan, TR | 1 |
| Green, K | 2 |
| Bowman, K | 1 |
| Elijah, D | 1 |
| Lollis, G | 1 |
| Nathanson, JA | 3 |
| van Bijsterveld, OP | 1 |
| van Loenen, AC | 1 |
| ten Ham, M | 1 |
| Caprioli, J | 1 |
| Sears, M | 1 |
| Bausher, L | 1 |
| Gregory, D | 1 |
| Mead, A | 1 |
| Brubaker, RF | 1 |
| Gaasterland, D | 2 |
| Hoyng, PF | 2 |
| van Alphen, GW | 1 |
| Haddeman, E | 1 |
| Miichi, H | 1 |
| Nagataki, S | 1 |
| Neetens, A | 4 |
| Delaunois, AL | 1 |
| Hendrata, Y | 1 |
| Van Rompaey, J | 1 |
| Chu, TC | 1 |
| Ogidigben, M | 1 |
| Han, JC | 1 |
| Pech, B | 1 |
| Chetoni, P | 2 |
| Saettone, MF | 2 |
| Duval, O | 1 |
| Benoit, JP | 1 |
| Santafe, J | 1 |
| Segarra, J | 1 |
| Garrido, M | 1 |
| Pablo, V | 1 |
| Martinez de Ibarreta, MJ | 1 |
| Hynie, S | 3 |
| Cepelík, J | 3 |
| Cappanera, L | 1 |
| Conte, U | 1 |
| Finne, U | 1 |
| Järvinen, K | 1 |
| Salivirta, J | 1 |
| Urtti, A | 1 |
| Marchal-Heussler, L | 1 |
| Sirbat, D | 1 |
| Hoffman, M | 1 |
| Maincent, P | 1 |
| Bodor, N | 2 |
| Farag, HH | 1 |
| Somogyi, G | 1 |
| Wu, WM | 1 |
| Barros, MD | 1 |
| Prokai, L | 1 |
| Schmetterer, L | 1 |
| Findl, O | 1 |
| Strenn, K | 1 |
| Fasching, P | 1 |
| Zanaschka, G | 1 |
| Eichler, HG | 1 |
| Wolzt, M | 1 |
| Hong, SJ | 1 |
| Wu, KY | 1 |
| Chen, IJ | 1 |
| Dedina, M | 1 |
| Sharif, NA | 2 |
| Xu, SX | 2 |
| Crider, JY | 2 |
| McLaughlin, M | 2 |
| Davis, TL | 2 |
| Vareilles, P | 1 |
| Silverstone, D | 1 |
| Plazonnet, B | 1 |
| Le Douarec, JC | 1 |
| Sears, ML | 4 |
| Stone, CA | 1 |
| Colasanti, BK | 1 |
| Trotter, RR | 1 |
| Lamble, JW | 1 |
| Lamble, AP | 1 |
| Chiou, CY | 1 |
| Zimmerman, TJ | 1 |
| Leopold, IH | 1 |
| Murray, DL | 1 |
| Kupfer, C | 2 |
| Kass, MA | 1 |
| Reid, TW | 1 |
| Bausher, LP | 1 |
| Virno, M | 1 |
| Pellegrino, N | 1 |
| Pecori-Giraldi, J | 1 |
| Latinovic, S | 1 |
| Bucci, MG | 1 |
| Pescosolido, N | 1 |
| Ross, RA | 4 |
| Drance, SM | 4 |
| Seidehamel, RJ | 1 |
| Dungan, KW | 1 |
| Hickey, TE | 1 |
| Losa, C | 1 |
| Alonso, MJ | 1 |
| Vila, JL | 1 |
| Orallo, F | 1 |
| Martinez, J | 1 |
| Saavedra, JA | 1 |
| Pastor, JC | 1 |
| Bauer, K | 1 |
| Brunner-Ferber, F | 1 |
| Distlerath, LM | 1 |
| Lippa, EA | 1 |
| Binkowitz, B | 1 |
| Till, P | 1 |
| Kaik, G | 1 |
| Jin, Y | 1 |
| Wilson, S | 1 |
| Elko, EE | 1 |
| Yorio, T | 1 |
| Groeneboer, MC | 1 |
| Busch, MJ | 1 |
| Elkoussi, A | 1 |
| Kiuchi, Y | 1 |
| Sugrue, MF | 1 |
| Armstrong, JM | 1 |
| Gautheron, P | 1 |
| Mallorga, P | 1 |
| Viader, MP | 1 |
| Palkama, A | 1 |
| Uusitalo, H | 1 |
| Raij, K | 1 |
| Uusitalo, R | 1 |
| Woodward, DF | 3 |
| Chen, J | 2 |
| Padillo, E | 1 |
| Ruiz, G | 1 |
| Berlin, I | 1 |
| Marcel, P | 1 |
| Uzzan, B | 1 |
| Millon, D | 1 |
| Le Hoang, P | 1 |
| Puech, AJ | 1 |
| Dowling, MC | 1 |
| Feldmann, BJ | 1 |
| Shumate, DJ | 1 |
| Bundgaard, H | 1 |
| Lee, VH | 1 |
| Novack, GD | 1 |
| Williams, LS | 1 |
| Nieves, AL | 1 |
| Lu, DY | 1 |
| Mittag, TW | 1 |
| Tormay, A | 1 |
| Podos, SM | 1 |
| Gherezghiher, T | 1 |
| Hey, JA | 1 |
| Koss, MC | 1 |
| Bernat, RA | 1 |
| Kodama, T | 1 |
| Reddy, VN | 1 |
| Macri, FJ | 1 |
| Ross, K | 1 |
| Gabelnick, HL | 1 |
| Holland, MG | 3 |
| Jampol, LM | 1 |
| Alm, A | 1 |
| Chavis, RM | 1 |
| Baldwin, HA | 1 |
| Leaders, FE | 4 |
| Langham, ME | 4 |
| Diggs, E | 1 |
| Wei, CP | 1 |
| Cole, DF | 1 |
| Nagasubramanian, S | 1 |
| Bernard, PJ | 1 |
| Cevario, SJ | 1 |
| Kitazawa, Y | 1 |
| Bill, A | 1 |
| Mims, JL | 1 |
| Norton, AL | 1 |
| Viernstein, LJ | 1 |
| Bhattacherjee, P | 1 |
| Lorenzetti, OJ | 1 |
| Schulz, W | 1 |
| van Zwieten, PA | 1 |
| Chiang, TS | 1 |
| Ershkovich, IG | 1 |
| Lozovaia, GN | 1 |
| Fortenberry, B | 1 |
| Kagawa, CM | 1 |
| McDonald, TO | 1 |
| Hodges, JW | 1 |
| Borgmann, AR | 1 |
2 reviews available for isoproterenol and Intraocular Pressure
| Article | Year |
|---|---|
Autonomic drugs in ophthalmology: some problems and promises. Section III: Sympathomimetic drugs.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Aqueous Humor; Cats; Cornea; Depression, Chemical; Epi | 1974 |
Role of adrenergic mechanisms in development and therapy of open-angled glaucoma.
Topics: Adolescent; Adult; Animals; Aqueous Humor; Dibenzocycloheptenes; Drug Synergism; Epinephrine; Glauco | 1971 |
3 trials available for isoproterenol and Intraocular Pressure
| Article | Year |
|---|---|
Assessment of systemic effects of different ophthalmic beta-blockers in healthy volunteers.
Topics: Adrenergic beta-Antagonists; Adult; Bronchi; Dose-Response Relationship, Drug; Double-Blind Method; | 1991 |
A single dose of three different ophthalmic beta-blockers antagonizes the chronotropic effect of isoproterenol in healthy volunteers.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Carteolol; Double-Blind Method; Heart Rate; Huma | 1987 |
Effects of topically applied isoproterenol on aqueous dynamics in man.
Topics: Aged; Aqueous Humor; Clinical Trials as Topic; Female; Humans; Intraocular Pressure; Isoproterenol; | 1970 |
90 other studies available for isoproterenol and Intraocular Pressure
| Article | Year |
|---|---|
Identification of novel competing β2AR phospho-extracellular signal regulated kinase 1/2 signaling pathways in human trabecular meshwork cells.
Topics: Adrenergic beta-Agonists; Cells, Cultured; Colforsin; Gene Expression; GTP-Binding Protein alpha Sub | 2012 |
THE ACTION OF SYMPATHOMIMETIC AMINES ON THE OUTFLOW OF AQUEOUS HUMOUR FROM THE EYE.
Topics: Animals; Aqueous Humor; Denervation; Epinephrine; Eye Diseases; Intraocular Pressure; Isoproterenol; | 1964 |
[ON THE ACTION OF ALEUDRIN ON THE NORMAL HUMAN EYE].
Topics: Eye; Eye Diseases; Humans; Intraocular Pressure; Isoproterenol; Pharmacology; Tonometry, Ocular | 1964 |
[ON THE ACTION OF 2 SUBSTANCES WITH BETA-SYMPATOLYTIC ACTIVITY ON THE INTRAOCULAR PRESSURE OF THE RABBIT].
Topics: Animals; Intraocular Pressure; Isoproterenol; Lagomorpha; Pharmacology; Rabbits; Research; Sympathol | 1964 |
ACETAZOLAMIDE AND OCULAR TENSION; NOTES CONCERNING THE MECHANISM OF ACTION.
Topics: Acetazolamide; Adrenalectomy; Aorta; Bretylium Compounds; Dogs; Eye Diseases; Intraocular Pressure; | 1965 |
[EFFECT OF THE BETA-ADRENERGIC SUBSTANCE IN ISOPRENALIN ON THE OUTFLOW FACILITY IN RABBIT EYES].
Topics: Adrenergic Agents; Animals; Aqueous Humor; Eye Diseases; Intraocular Pressure; Isoproterenol; Lagomo | 1964 |
Prostaglandin influences on intraocular pressure and pupil size.
Topics: Animals; Anterior Chamber; Aqueous Humor; Atropine; Buffers; Cats; Eye; Intraocular Pressure; Isopro | 1967 |
Adrenergic drugs and intraocular pressure: suppression of ocular hypertension induced by water loading.
Topics: Adrenergic beta-Antagonists; Animals; Butoxamine; Dobutamine; Ephedrine; Epinephrine; Intraocular Pr | 1980 |
Pharmacological effects of topical timolol in the rabbit eye.
Topics: Adrenergic beta-Antagonists; Animals; Ciliary Body; Cyclic AMP; Eye; In Vitro Techniques; Intraocula | 1980 |
Effects of adrenergic agonists upon regional ocular blood flow in normal and ganglionectomized rabbits.
Topics: Adrenergic alpha-Agonists; Animals; Ciliary Body; Eye; Female; Ganglia, Sympathetic; Intraocular Pre | 1981 |
Steric structure activity relationships of various adrenergic agonists: ocular and systemic effects.
Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Epinephrine; Ethanolamines; Eye; Intraocular Pres | 1981 |
Drug effects on aqueous humor formation and pseudofacility in sympathectomized rabbit eyes.
Topics: Adrenergic Agonists; Animals; Aqueous Humor; Cell Membrane Permeability; Dose-Response Relationship, | 1982 |
ICI 118,551: an effective ocular hypotensive agent with selectivity for the ciliary process beta 2-adrenoceptor and with minimal cardiac side effects.
Topics: Adenylyl Cyclase Inhibitors; Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Ciliary | 1984 |
Adrenergic regulation of intraocular pressure: identification of beta 2-adrenergic-stimulated adenylate cyclase in ciliary process epithelium.
Topics: Adenylyl Cyclases; Animals; Ciliary Body; Enzyme Activation; Epithelium; Glaucoma; Intraocular Press | 1980 |
The effect of hypotensive drugs on the intraocular pressure after waterloading in rabbits.
Topics: Acetazolamide; Animals; Antihypertensive Agents; Dronabinol; Epinephrine; Intraocular Pressure; Isop | 1981 |
Forskolin lowers intraocular pressure by reducing aqueous inflow.
Topics: Adenylyl Cyclases; Animals; Aqueous Humor; Blood Pressure; Ciliary Body; Colforsin; Diterpenes; Dose | 1984 |
The effect of isoproterenol on aqueous humor formation in humans.
Topics: Anterior Chamber; Aqueous Humor; Cornea; Heart Rate; Humans; Intraocular Pressure; Isoproterenol | 1984 |
Does prostacyclin mediate alpha-adrenergic induced hypotension?
Topics: Animals; Aqueous Humor; Epinephrine; Epoprostenol; Indomethacin; Intraocular Pressure; Iris; Isoprot | 1982 |
Effects of cholinergic drugs and adrenergic drugs on aqueous humor formation in the rabbit eye.
Topics: Albuterol; Animals; Aqueous Humor; Atropine; Epinephrine; Female; Intraocular Pressure; Isoprotereno | 1982 |
Experimental animal study of the effects of intraocular pressure and systemic blood pressure on optic pathway action potentials.
Topics: Action Potentials; Animals; Blood Pressure; Cats; Intraocular Pressure; Isoproterenol; Norepinephrin | 1981 |
Allicin-induced hypotension in rabbit eyes.
Topics: Animals; Cells, Cultured; Ciliary Body; Cyclic AMP; Cysteine; Disulfides; Electric Stimulation; Fema | 1993 |
Preliminary evaluation of a series of amphiphilic timolol prodrugs: possible evidence for transscleral absorption.
Topics: Absorption; Animals; Cell Membrane Permeability; Cornea; Disease Models, Animal; Esters; Evaluation | 1993 |
Evidence for a synergistic interaction between isoprenaline and timolol on intraocular pressure in conscious rabbits.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Female; Intraocular Pressure; Isoproteren | 1993 |
Effects of pertussis toxin on intraocular pressure and adenylate cyclase activity of ciliary processes in rabbits.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Ciliary Body; Clon | 1993 |
Intraocular pressure reduction and systemic absorption of timolol after administration of one side-coated inserts in rabbits.
Topics: Absorption; Animals; Biological Availability; Drug Carriers; Drug Delivery Systems; Intraocular Pres | 1993 |
Poly(epsilon-caprolactone) nanocapsules in carteolol ophthalmic delivery.
Topics: Animals; Blood Pressure; Capsules; Carteolol; Chemical Phenomena; Chemistry, Physical; Heart Rate; H | 1993 |
Ocular-specific delivery of timolol by sequential bioactivation of its oxime and methoxime analogs.
Topics: Administration, Topical; Adrenergic beta-Agonists; Animals; Eye; Hydrolysis; Intraocular Pressure; I | 1997 |
Repeated topical administration of fenoterol in rabbit reverses its initial ocular hypotensive effect and decreases sensitivity of adenylyl cyclase in ciliary processes to stimulatory agents.
Topics: Adenylyl Cyclases; Administration, Topical; Adrenergic beta-Agonists; Animals; Ciliary Body; Colfors | 1997 |
Ocular and systemic reactivity to isoprenaline in patients with insulin-dependent diabetes mellitus.
Topics: Adrenergic beta-Agonists; Adult; Blood Pressure; Diabetes Mellitus, Type 1; Eye; Fundus Oculi; Hemod | 1997 |
Ocular hypotensive and vasodilative effects of two beta-adrenergic blockers with intrinsic sympathomimetic activity.
Topics: Adrenergic beta-Antagonists; Animals; Aorta; Butanones; Cell Line; Ciliary Body; Cyclic AMP; Eugenol | 1998 |
The effects of adrenergic agonists on intraocular pressure and on adenylyl cyclase activity of ciliary processes in pigmented rabbits.
Topics: Adenylyl Cyclases; Administration, Topical; Adrenergic beta-Agonists; Animals; Ciliary Body; Clenbut | 1998 |
Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Cell Line; Ciliary Body; | 2001 |
Levobetaxolol (Betaxon): in vitro pharmacology, intraocular pressure lowering activity and autoradiographic localization of beta-adrenoceptors in human eyes.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Autoradiography; Betaxolol; Binding, | 2001 |
Comparison of the effects of timolol and other adrenergic agents on intraocular pressure in the rabbit.
Topics: Adrenergic beta-Antagonists; Animals; Aqueous Humor; Chymotrypsin; Disease Models, Animal; Epinephri | 1977 |
Responsiveness of the rabbit eye to adrenergic and cholinergic agonists after treatment with 6-hydroxydopamine or alpha-methyl-para-tyrosine: part II--intraocular pressure changes.
Topics: Adrenergic Agonists; Animals; Carbachol; Echothiophate Iodide; Epinephrine; Hydroxydopamines; Intrao | 1978 |
Effects of adrenergic drugs on aqueous cAMP and cGMP and intraocular pressure.
Topics: Administration, Topical; Adrenergic Agonists; Animals; Aqueous Humor; Cyclic AMP; Cyclic GMP; Epinep | 1979 |
Effects of catecholamines on the intraocular pressure of conscious owl monkeys.
Topics: Animals; Catecholamines; Dose-Response Relationship, Drug; Epinephrine; Haplorhini; Humans; Intraocu | 1977 |
Influences of cyclic nucleotides on outflow facility in the vervet monkey.
Topics: Animals; Aqueous Humor; Bucladesine; Chlorocebus aethiops; Cyclic AMP; Cyclic GMP; Epinephrine; Fema | 1978 |
Editorial: Ocular hypotensive effects of autonomic drugs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A | 1975 |
Ocular hypotensive action of labetalol.
Topics: Animals; Ethanolamines; Female; Intraocular Pressure; Isoproterenol; Labetalol; Norepinephrine; p-Hy | 1979 |
Drugs and glaucoma.
Topics: Adult; Age Factors; Aged; Aqueous Humor; Circadian Rhythm; Epinephrine; Glaucoma; Humans; Intraocula | 1978 |
Adrenergic activity and intraocular pressure.
Topics: Abducens Nerve; Animals; Carotid Arteries; Constriction; Dogs; Electric Stimulation; Gallamine Triet | 1977 |
The effect of d-isoproterenol on intraocular pressure of the rabbit, monkey, and man.
Topics: Administration, Topical; Animals; Chymotrypsin; Glaucoma; Haplorhini; Humans; Intraocular Pressure; | 1976 |
[Vascular effects of adrenergic drugs and their action on intraocular pressure (author's transl)].
Topics: Animals; Dibenzylchlorethamine; Epinephrine; Ergotamine; Eye; Female; Intraocular Pressure; Isoprote | 1977 |
[On the possibility of reducing systemic side-effects of isoproterenol eyedrops by means of topical propranolol (author's transl)].
Topics: Adolescent; Adult; Glaucoma; Humans; Intraocular Pressure; Isoproterenol; Ophthalmic Solutions; Prop | 1977 |
The effects of the catecholamines and related drugs on intraocular pressure.
Topics: Aqueous Humor; Catecholamines; Ciliary Body; Drug Therapy, Combination; Epinephrine; Glaucoma; Human | 1975 |
Specific hypotensive and antihypertensive ocular effects of d-isoproterenol in rabbits.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Female; Heart Ra | 1975 |
Reduction of cardiovascular side effects associated with ocular administration of metipranolol by inclusion in polymeric nanocapsules.
Topics: Animals; Blood Pressure; Capsules; Drug Delivery Systems; Heart Rate; Intraocular Pressure; Isoprote | 1992 |
Ocular hypotensive effects of medetomidine and its analogs.
Topics: Adenylyl Cyclase Inhibitors; Adrenergic alpha-Agonists; Animals; Cats; Ciliary Body; Dose-Response R | 1991 |
Isobutylmethylxanthine enhances adrenergic-induced ocular hypotension in rabbits and beagles.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Animals; Aqueous Humor; Cyclic AMP; Dogs; Do | 1991 |
Improved delivery through biological membranes. LVI. Pharmacological evaluation of alprenoxime--a new potential antiglaucoma agent.
Topics: Alprenolol; Animals; Drug Delivery Systems; Heart Rate; Infusions, Intravenous; Injections, Intraven | 1991 |
[Changes in ocular hypotensive effect of griseolic acid with isoproterenol, timolol and melanin].
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Depression, Chemical; Drug Synergism; Femal | 1990 |
A study on the ocular and extraocular pharmacology of metipranolol.
Topics: Animals; Blood Pressure; Chymotrypsin; Dose-Response Relationship, Drug; Eye; Heart Rate; Intraocula | 1985 |
Comparison of the effects of adrenergic agonists and alpha-, beta 1-, beta 2-antagonists on the intraocular pressure and adenylate cyclase activity in the ciliary processes of the rabbit.
Topics: Acebutolol; Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic b | 1985 |
Biochemical and physiological effects of S-32-468, a beta-adrenoceptor antagonist with possible oculoselectivity.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Ciliary Body; Enzyme Activation; Humans; In | 1985 |
Pharmacological characterization of beta-adrenoceptor subtype involvement in the ocular hypotensive response to beta-adrenergic stimulation.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Dose-Response Relationship, Drug; Fe | 1986 |
Topical timolol, at conventional, unilateral doses causes bilateral ocular beta-blockade in rabbits.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Blood Pressure; Dose-Response Relatio | 1987 |
Ocular and cardiac beta-antagonism by timolol prodrugs, timolol and levobunolol.
Topics: Adrenergic beta-Antagonists; Animals; Eye; Heart; Heart Rate; Intraocular Pressure; Isoproterenol; L | 1988 |
Dihydrolevobunolol is a potent ocular beta-adrenoceptor antagonist.
Topics: Adrenergic beta-Antagonists; Animals; Chemical Phenomena; Chemistry; Eye; Female; Intraocular Pressu | 1987 |
[Cyclic-nucleotides and adrenergic antiglaucoma drugs].
Topics: Animals; Aqueous Humor; Cyclic AMP; Cyclic GMP; Intraocular Pressure; Isoproterenol; Norepinephrine; | 1985 |
Vasoactive intestinal peptide and intraocular pressure: adenylate cyclase activation and binding sites for vasoactive intestinal peptide in membranes of ocular ciliary processes.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Ciliary Body; Dose-Response Relationship, Drug; En | 1987 |
Systemic blood pressure and intraocular pressure relationship.
Topics: Angiotensin II; Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Female; Injections, | 1988 |
[Effect of prostaglandins and sympathomimetic amines on the production and chemical composition of the aqueous humor].
Topics: Animals; Aqueous Humor; Intraocular Pressure; Isoproterenol; Phenylephrine; Prostaglandins E, Synthe | 1987 |
Pharmacological study on the effects of some ocular hypotensive drugs on aqueous humor formation in the arterially perfused enucleated rabbit eye.
Topics: Acetazolamide; Animals; Aqueous Humor; Arteries; Autonomic Agents; Dinitrophenols; Epinephrine; In V | 1985 |
Studies of aqueous humor dynamics in man. 3. Measurements in young normal subjects using norepinephrine and isoproterenol.
Topics: Adrenergic alpha-Agonists; Aqueous Humor; Epinephrine; Humans; Intraocular Pressure; Isoproterenol; | 1973 |
Cyclic-AMP in the aqueous humor: the effects of adrenergic agents.
Topics: Aminophylline; Animals; Aqueous Humor; Caffeine; Ciliary Body; Cornea; Cyclic AMP; Epinephrine; Intr | 1972 |
Effects of norepinephrine, angiotensin, dihydroergotamine, papaverine, isoproterenol, histamine, nicotinic acid, and xanthinol nicotinate on retinal oxygen tension in cats.
Topics: Angiotensin II; Animals; Blood Pressure; Cats; Ergotamine; Female; Histamine; Intraocular Pressure; | 1972 |
Cyclic-AMP in the aqueous humor: the effects of repeated topical epinephrine administration and sympathetic denervation.
Topics: Adenylyl Cyclases; Animals; Aqueous Humor; Cyclic AMP; Epinephrine; Ganglia, Autonomic; Injections; | 1973 |
Effects of prostaglandin and beta-adrenergic drugs on ocular pressure and pupil size.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Drug Antagonism; Intraocular Pressur | 1969 |
Comparative corneal penetration and adrenergic mechanism of isoproterenol, epinephrine, levarterenol and compound AL842 in rabbits.
Topics: Adrenergic beta-Agonists; Animals; Cornea; Dose-Response Relationship, Drug; Epinephrine; Ethanolami | 1972 |
Beta-adrenergic responses in the eyes of rabbits, primates, and man.
Topics: Administration, Topical; Adult; Albuterol; Animals; Aqueous Humor; Ascorbic Acid; Dilatation; Eye; H | 1974 |
Chemical sympathectomy in glaucoma therapy: an investigation of alpha and beta adrenergic supersensitivity.
Topics: Aqueous Humor; Drug Hypersensitivity; Eye; Glaucoma; Humans; Hydroxydopamines; Intraocular Pressure; | 1973 |
Substances affecting active transport across the ciliary epithelium and their possible role in determining intraocular pressure.
Topics: Animals; Aqueous Humor; Biological Transport, Active; Catecholamines; Cell Membrane Permeability; Ci | 1973 |
Proceedings: The influence of adrenergic drugs on intraocular pressure in the anaesthetized dog.
Topics: Anesthesia; Animals; Blood Pressure; Dogs; Epinephrine; Intraocular Pressure; Isoproterenol; Norepin | 1973 |
The influence of adrenergic drugs on intraocular pressure in the anaesthetized dog.
Topics: Animals; Blood Pressure; Carotid Arteries; Dogs; Intraocular Pressure; Isoproterenol; Jugular Veins; | 1973 |
A pharmacodynamic study of the inhibitory effects of 1-norepinephrin, 1-epinephrine, and d, 1-isoproterenol on aqueous humor formation in the enucleated, arterially perfused cat eye.
Topics: Acetylcholine; Animals; Aqueous Humor; Cats; Epinephrine; Intraocular Pressure; Isoproterenol; Norep | 1974 |
Influence of an adrenergic potentiator on the ocular response to catecholamines in primates and man.
Topics: Animals; Antidepressive Agents; Aqueous Humor; Drug Synergism; Epinephrine; Eye; Haplorhini; Humans; | 1968 |
Effects of norepinephrine, isoproterenol and sympathetic stimulation on aqueous humour dynamics in vervet monkeys.
Topics: Animals; Aqueous Humor; Ciliary Body; Electric Stimulation; Eye; Female; Haplorhini; Intraocular Pre | 1970 |
Anterior segment chemical sympathectomy by 6-hydroxy-dopamine. I. Effect on intraocular pressure and facility of outflow.
Topics: Animals; Aqueous Humor; Blood Pressure; Catheterization; Depression, Chemical; Dopamine; Female; Hap | 1971 |
The effect of adrenergic agents on ocular dynamics as a function of administration site.
Topics: Animals; Aqueous Humor; Epinephrine; Female; Injections; Intraocular Pressure; Isoproterenol; Male; | 1972 |
Effects of catecholamines on the ocular tension of normal and sympathetically denervated rabbit eyes.
Topics: Animals; Anterior Chamber; Autoradiography; Catecholamines; Cornea; Denervation; Epinephrine; Eye; I | 1971 |
Dose-dependent influence of topically instilled adrenergic agents on intraocular pressure and outflow facility in the rabbit.
Topics: Animals; Anterior Chamber; Aqueous Humor; Blood Pressure; Epinephrine; Heart Rate; Intraocular Press | 1971 |
The influence of drugs that change blood pressure on intraocular pressure in the anaesthetized rat.
Topics: Acetazolamide; Animals; Arteries; Blood Pressure; Blood Pressure Determination; Epinephrine; Hexamet | 1971 |
The effects of topical isoproterenol on aqueous dynamics in man.
Topics: Humans; Intraocular Pressure; Isoproterenol; Ophthalmic Solutions; Tachycardia; Tonometry, Ocular | 1970 |
Antagonism of formaldehyde-induced ocular hypertension by phenylethylamines.
Topics: Animals; Drug Antagonism; Epinephrine; Formaldehyde; Intraocular Pressure; Isoproterenol; Norepineph | 1970 |
[The use of Euspiran in glaucoma].
Topics: Adult; Aged; Glaucoma; Humans; Intraocular Pressure; Isoproterenol; Male; Middle Aged | 1967 |
A chemically induced experimental ocular hypertension for evaluating drug effects in albino rabbits.
Topics: Animals; Carbachol; Epinephrine; Female; Formaldehyde; Glaucoma; Hypertension; Intraocular Pressure; | 1969 |
The water-loading test in rabbits. A method to detect potential ocular hypotensive drugs.
Topics: Acetazolamide; Animals; Atropine; Carbachol; Dichlorphenamide; Epinephrine; Glaucoma; Hexamethonium | 1969 |
The effects of single instillations of isoproterenol on intraocular pressure in man.
Topics: Aged; Blood Pressure; Female; Glaucoma; Humans; Intraocular Pressure; Isoproterenol; Male; Middle Ag | 1969 |
The response of the pupil and intraocular pressure of conscious rabbits to adrenergic drugs following unilateral superior cervical ganglionectomy.
Topics: Animals; Intraocular Pressure; Isoproterenol; Norepinephrine; Phenoxybenzamine; Pupil; Rabbits; Symp | 1965 |