isoproterenol has been researched along with Idiopathic Parkinson Disease in 17 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Patients with PD+NOH had normal bradycardia responses to edrophonium and normal epinephrine responses to glucagon." | 3.74 | Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension. ( Goldstein, DS; Holmes, C; Imrich, R; Pechnik, S; Sharabi, Y, 2008) |
| "Diseases characterized by neurogenic orthostatic hypotension (NOH), such as Parkinson disease (PD) and pure autonomic failure (PAF), are associated with cardiac sympathetic denervation, as reflected by low myocardial concentrations of 6-[(18)F]fluorodopamine-derived radioactivity." | 1.35 | Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension. ( Bentho, O; Eldadah, BA; Goldstein, DS; Grossman, E; Holmes, C; Imrich, R; Pechnik, S; Sharabi, Y, 2009) |
| "We studied 10 Parkinson's disease patients and examined adipose tissue and skeletal muscle metabolism directly with microdialysis." | 1.35 | Influences of levodopa on adipose tissue and skeletal muscle metabolism in patients with idiopathic Parkinson's disease. ( Adams, F; Boschmann, M; Franke, G; Gottschalk, S; Janke, J; Jordan, J; Kupsch, A; Leisse, MC; Lipp, A; Lobsien, E; Spranger, J, 2008) |
| "Certain clinical manifestations of Parkinson's disease (PD) (speech or/and balance disturbances) are not linked to brain dopamine deficiency." | 1.28 | Cardiac beta-adrenoceptor sensitivity and Parkinson's disease. ( Allain, H; Bentue-Ferrer, D; Decombe, R; Lemaitre, MH; Martinet, JP; Milon, D, 1991) |
| "The typical 'tremor-at-rest' of Parkinson's disease--3-7 Hz activity which alternates between antagonistic muscles--is suppressed, at least briefly, during voluntary activity, at which time typical 8--12 Hz 'physiological tremor' may be seen." | 1.26 | Physiological and pharmacological aids in the differential diagnosis of tremor. ( Shahani, BT; Young, RR, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (47.06) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weichert, D | 1 |
| Stanek, M | 1 |
| Hübner, H | 1 |
| Gmeiner, P | 1 |
| Lv, H | 1 |
| Yu, F | 1 |
| Sha, C | 1 |
| Huang, Y | 1 |
| Lu, Y | 1 |
| Zhang, L | 1 |
| Zhai, R | 1 |
| Wang, T | 1 |
| Fu, F | 1 |
| Imrich, R | 2 |
| Eldadah, BA | 1 |
| Bentho, O | 1 |
| Pechnik, S | 2 |
| Sharabi, Y | 2 |
| Holmes, C | 2 |
| Grossman, E | 1 |
| Goldstein, DS | 2 |
| Adams, F | 1 |
| Boschmann, M | 1 |
| Lobsien, E | 1 |
| Kupsch, A | 1 |
| Lipp, A | 1 |
| Franke, G | 1 |
| Leisse, MC | 1 |
| Janke, J | 1 |
| Gottschalk, S | 1 |
| Spranger, J | 1 |
| Jordan, J | 1 |
| CONSTAS, C | 1 |
| Marsden, CD | 1 |
| Foley, TH | 1 |
| Owen, DA | 1 |
| McAllister, RG | 1 |
| Hirayama, M | 1 |
| Hakusui, S | 1 |
| Koike, Y | 1 |
| Ito, K | 1 |
| Kato, T | 1 |
| Ikeda, M | 1 |
| Hasegawa, Y | 1 |
| Takahashi, A | 1 |
| Ishikawa, A | 1 |
| Shahani, BT | 2 |
| Young, RR | 2 |
| Milon, D | 1 |
| Allain, H | 1 |
| Bentue-Ferrer, D | 1 |
| Martinet, JP | 1 |
| Lemaitre, MH | 1 |
| Decombe, R | 1 |
| Durrieu, G | 1 |
| Rispail, Y | 1 |
| Chatelut, E | 1 |
| Berlan, M | 1 |
| Rascol, A | 1 |
| Montastruc, JL | 1 |
| Montastruc, P | 1 |
| Papavasiliou, PS | 1 |
| Miller, ST | 1 |
| Cotzias, GC | 1 |
| Jacobi, H | 1 |
| von Egidy, H | 1 |
| Vollum, DI | 1 |
| Parkes, JD | 1 |
| Doyle, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Identifying the Pathophysiology of Neurogenic Orthostatic Hypotension and the Effects of Melatonin on Reducing Supine Hypertension in Peripherally Intact Versus Denervated Post-ganglionic Sympathetic Nerves[NCT02963181] | Early Phase 1 | 10 participants (Actual) | Interventional | 2018-03-01 | Terminated (stopped due to PI leaving) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for isoproterenol and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
[Progress in diagnosis and treatment of juvenile parkinsonism].
Topics: Adolescent; Adult; Age of Onset; Child; Drug Tolerance; Female; Humans; Isoproterenol; Levodopa; Mal | 1993 |
1 trial available for isoproterenol and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Peripheral beta-adrenergic receptors concerned with tremor.
Topics: Adult; Arteries; Blood Circulation; Bradykinin; Catecholamines; Epinephrine; Fingers; Forearm; Human | 1967 |
15 other studies available for isoproterenol and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Structure-guided development of dual β2 adrenergic/dopamine D2 receptor agonists.
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Benzoxazines; CHO Cells; Cricetulus; Dopamine Agonists | 2016 |
Effects of rotigotine and rotigotine extended-release microsphere therapy on myocardial ischemic injury in mice.
Topics: Animals; Cardiotonic Agents; Chlorpromazine; Creatine Kinase, MB Form; Dopamine Agonists; Isoprotere | 2019 |
Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension.
Topics: Adrenergic beta-Agonists; Aged; Autonomic Nervous System Diseases; Blood Pressure; Dopamine; Female; | 2009 |
Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension.
Topics: Aged; Blood Pressure; Bradycardia; Cholinesterase Inhibitors; Edrophonium; Epinephrine; Female; Gluc | 2008 |
Influences of levodopa on adipose tissue and skeletal muscle metabolism in patients with idiopathic Parkinson's disease.
Topics: Adipocytes; Adipose Tissue; Aged; Antiparkinson Agents; Benserazide; Dose-Response Relationship, Dru | 2008 |
The effects of adrenaline, noradrenaline, and isoprenaline on parkinsonian tremor.
Topics: Epinephrine; Humans; Isoproterenol; Norepinephrine; Parkinson Disease; Sympathomimetics; Tremor | 1962 |
A scintigraphical qualitative analysis of peripheral vascular sympathetic function with meta-[123I]iodobenzylguanidine in neurological patients with autonomic failure.
Topics: 3-Iodobenzylguanidine; Aged; Autonomic Nervous System Diseases; Female; Humans; Iodine Radioisotopes | 1995 |
Physiological and pharmacological aids in the differential diagnosis of tremor.
Topics: Ataxia; Diagnosis, Differential; Ethanol; Humans; Isoproterenol; Levodopa; Methods; Parkinson Diseas | 1976 |
Analysis of single motor unit discharge patterns in different types of tremor.
Topics: Humans; Isoproterenol; Motor Neurons; Parkinson Disease; Receptors, Adrenergic, beta; Tremor | 1978 |
Cardiac beta-adrenoceptor sensitivity and Parkinson's disease.
Topics: Aged; Aging; Blood Pressure; Bromocriptine; Dose-Response Relationship, Drug; Female; Heart Rate; Hu | 1991 |
Beta-adrenergic sensitivity in Parkinson's disease: effect of levodopa treatment.
Topics: Aged; Dose-Response Relationship, Drug; Epinephrine; Fatty Acids, Nonesterified; Female; Heart Rate; | 1990 |
Functional interactions between biogenic amines, 3',5'-cyclic AMP and manganese.
Topics: Adenine Nucleotides; Animals; Bile; Cyclic AMP; Dihydroxyphenylalanine; Dopamine; Epinephrine; Gluca | 1968 |
[Inhibition of tremor by active beta-adrenolytic substances].
Topics: Animals; Depression, Chemical; Isoproterenol; Mice; Parkinson Disease; Propranolol; Sensory Receptor | 1967 |
[What is assured in treatment with beta receptor blockaders?].
Topics: Acetanilides; Adrenergic beta-Antagonists; Alprenolol; Amino Alcohols; Cresols; Heart Diseases; Huma | 1972 |
Livedo reticularis during amantadine treatment.
Topics: Aged; Amantadine; Ankle; Blood Vessels; Edema; Epinephrine; Female; Humans; Isoproterenol; Male; Mid | 1971 |