Page last updated: 2024-10-29

isoproterenol and Hypothermia

isoproterenol has been researched along with Hypothermia in 25 studies

Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.

Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.

Research Excerpts

ExcerptRelevanceReference
"Milrinone and isoprenaline both significantly increases action potential triangulation during hypothermia, and thereby the risk of ventricular arrhythmias."8.31Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study. ( Burton, F; Dietrichs, ES; Ghasemi, M; Selli, AL; Smith, G; Watters, T, 2023)
"Enhancement of myofilament Ca(2+) sensitivity is involved in the improvement of cardiac function by isoproterenol under spontaneous beating during hypothermia."7.71Isoproterenol enhances myofilament Ca(2+) sensitivity during hypothermia in isolated guinea pig beating hearts. ( Fujita, S; Nakae, Y; Namiki, A, 2001)
"Clonidine administered to mice induced hypothermia and this effect was antagonized by a single dose of the following beta-agonists: salbutamol, isoprenaline and terbutaline."7.66Influence of salbutamol and other beta-agonists on hypothermia induced by clonidine, apomorphine and reserpine in mice. ( Mogilnicka, E; Müller, M, 1981)
"Milrinone and isoprenaline both significantly increases action potential triangulation during hypothermia, and thereby the risk of ventricular arrhythmias."4.31Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study. ( Burton, F; Dietrichs, ES; Ghasemi, M; Selli, AL; Smith, G; Watters, T, 2023)
"Enhancement of myofilament Ca(2+) sensitivity is involved in the improvement of cardiac function by isoproterenol under spontaneous beating during hypothermia."3.71Isoproterenol enhances myofilament Ca(2+) sensitivity during hypothermia in isolated guinea pig beating hearts. ( Fujita, S; Nakae, Y; Namiki, A, 2001)
"Clonidine administered to mice induced hypothermia and this effect was antagonized by a single dose of the following beta-agonists: salbutamol, isoprenaline and terbutaline."3.66Influence of salbutamol and other beta-agonists on hypothermia induced by clonidine, apomorphine and reserpine in mice. ( Mogilnicka, E; Müller, M, 1981)
"None of the drugs caused arrhythmias during the experiments."1.28Myocardial effects of adrenaline, isoprenaline and dobutamine at hypothermic conditions. ( Nielsen-Kudsk, F; Riishede, L, 1990)
"The atropine test was found to be an efficient and simple diagnostic aid in cases of brain death."1.25Electrocardiographic findings in brain death; description and presumed mechanism. ( Drory, Y; Kellermann, JJ; Kosary, IZ; Ouaknine, G, 1975)
" Intraventricular injection of phenylephrine produced a dose-dependent hypothermia, whereas no dose-response relationship was obtained by isoproterenol."1.25[Role of brain biogenic amines in the central thermoregulatory mechanism of the rat (author's transl)]. ( Fukushima, N, 1975)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-199019 (76.00)18.7374
1990's2 (8.00)18.2507
2000's3 (12.00)29.6817
2010's0 (0.00)24.3611
2020's1 (4.00)2.80

Authors

AuthorsStudies
Selli, AL1
Ghasemi, M1
Watters, T1
Burton, F1
Smith, G1
Dietrichs, ES1
Tabarov, MS1
Kudryashov, YA1
LORENTZ, G1
ANGELUCCI, L1
GOODYER, AV1
Hiranandani, N1
Varian, KD1
Monasky, MM1
Janssen, PM1
Jones, SB1
Romano, FD1
Dooley, DJ1
Hungar, AA1
Nelson, WL1
Bowden, DM1
Müller, M1
Mogilnicka, E1
Nakae, Y1
Fujita, S1
Namiki, A1
Esteban, A1
Landin, L1
de la Cal, MA1
Caballero, J1
Broadley, KJ1
Duncan, C1
Drory, Y1
Ouaknine, G1
Kosary, IZ1
Kellermann, JJ1
Harari, A2
Regnier, B1
Rapin, M2
Lemaire, F2
Le Gall, JR2
Fukushima, N1
Sakagoshi, N1
Matsuda, H1
Watanabe, Y1
Kaneko, M1
Sawa, Y1
Yoshida, H1
Kawashima, Y1
Riishede, L1
Nielsen-Kudsk, F1
Kulinskiĭ, VI1
Gertsov, GE1
Plotnikov, NIu1
Bezachev, VG1
Wilson, KM1
Fregly, MJ1
Apstein, CS1
Dennis, RC1
Briggs, L1
Vogel, WM1
Frazer, J1
Valeri, CR1
Kar, K1
Sur, RN1
Pradhan, SN1
Kendle, KE1
Bennett, JP1
Regnier, A1
Day, EA1
Morgan, EB1
Koppanyi, T1
Maling, HM1
Lareng, L1
Cathala, B1
Fardou, H1
Jorda, MF1

Reviews

1 review available for isoproterenol and Hypothermia

ArticleYear
Accidental hypothermia: report of a case following alcohol and barbiturate overdose.
    Anaesthesia and intensive care, 1974, Volume: 2, Issue:1

    Topics: Adult; Alcoholic Intoxication; Blood Pressure; Electric Countershock; Female; Humans; Hypothermia; I

1974

Other Studies

24 other studies available for isoproterenol and Hypothermia

ArticleYear
Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study.
    Scandinavian journal of trauma, resuscitation and emergency medicine, 2023, Oct-25, Volume: 31, Issue:1

    Topics: Cardiotonic Agents; Heart Diseases; Humans; Hydrazones; Hypothermia; Isoproterenol; Milrinone; Myocy

2023
Dilatory humoral adrenergic reactions of regional veins and arteries during systemic hypoxia and hypothermia.
    Bulletin of experimental biology and medicine, 2002, Volume: 133, Issue:1

    Topics: Adrenergic beta-Agonists; Animals; Arteries; Cats; Hypothermia; Hypoxia; Intestine, Small; Isoproter

2002
[ACTION AND DISTRIBUTION OF VARIOUS DRUGS IN DEEP EXPERIMENTAL HYPOTHERMIA].
    Archivio italiano di scienze farmacologiche, 1963, Volume: 13

    Topics: Body Temperature; Dogs; Electrocardiography; Epinephrine; Hot Temperature; Hypothermia; Hypothermia,

1963
EFFECTS OF HYPOTHERMIA AND PYREXIA ON LEFT VENTRICULAR FUNCTION IN THE INTACT ANIMAL.
    The American journal of cardiology, 1965, Volume: 15

    Topics: Animals; Autonomic Nerve Block; Body Temperature; Bradycardia; Cardiac Output; Dogs; Fever; Heart; H

1965
Frequency-dependent contractile response of isolated cardiac trabeculae under hypo-, normo-, and hyperthermic conditions.
    Journal of applied physiology (Bethesda, Md. : 1985), 2006, Volume: 100, Issue:5

    Topics: Adrenergic beta-Agonists; Animals; Body Temperature Regulation; Fever; Hypothermia; Isoproterenol; M

2006
Functional characteristics and responses to adrenergic stimulation of isolated heart preparations from hypothermic and hibernating subjects.
    Cryobiology, 1984, Volume: 21, Issue:6

    Topics: Animals; Blood Pressure; Body Temperature; Cricetinae; Cyclic AMP; Female; Heart; Heart Rate; Hibern

1984
3-O-,4-O-diacetylisoproterenol and 3-O-,4-O-dibenzoylisoproterenol: hypothermic effects in mice and the involvement of beta-adrenergic receptors.
    European journal of pharmacology, 1981, Mar-12, Volume: 70, Issue:2

    Topics: Animals; Body Temperature; Brain; Dose-Response Relationship, Drug; Hypothermia; Isoproterenol; Male

1981
Influence of salbutamol and other beta-agonists on hypothermia induced by clonidine, apomorphine and reserpine in mice.
    Journal of neural transmission, 1981, Volume: 52, Issue:4

    Topics: Albuterol; Animals; Apomorphine; Clonidine; Drug Interactions; Hypothermia; Isoproterenol; Male; Mic

1981
Isoproterenol enhances myofilament Ca(2+) sensitivity during hypothermia in isolated guinea pig beating hearts.
    Anesthesia and analgesia, 2001, Volume: 93, Issue:4

    Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Calcium; Coronary Circulation; Electric Stimulati

2001
[Electrocardiographic changes in acute lesions of the CNS. Response to atropin and isoproterenol].
    Revista espanola de cardiologia, 1978, Volume: 31, Issue:5

    Topics: Atropine; Central Nervous System Diseases; Electrocardiography; Heart Rate; Humans; Hypothermia; Inj

1978
The individual and combined effects of hypothermia and reserpine pretreatment on the rate and tension responses to isoprenaline and salbutamol in guinea-pig atria [proceedings].
    British journal of pharmacology, 1976, Volume: 57, Issue:3

    Topics: Albuterol; Animals; Guinea Pigs; Heart Atria; Hypothermia; In Vitro Techniques; Isoproterenol; Myoca

1976
Electrocardiographic findings in brain death; description and presumed mechanism.
    Chest, 1975, Volume: 67, Issue:4

    Topics: Adolescent; Adult; Aged; Atropine; Brain Death; Brain Neoplasms; Child; Child, Preschool; Craniocere

1975
Haemodynamic study of prolonged deep accidental hypothermia.
    European journal of intensive care medicine, 1975, Volume: 1, Issue:2

    Topics: Accidents; Aged; Blood Pressure; Blood Volume; Body Temperature; Cardiac Output; Cardiac Volume; Cen

1975
[Role of brain biogenic amines in the central thermoregulatory mechanism of the rat (author's transl)].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1975, Volume: 50, Issue:4

    Topics: Adaptation, Physiological; Animals; Biogenic Amines; Blood Glucose; Body Temperature Regulation; Cer

1975
Alterations in the beta-adrenergic receptor system after hypothermic ischemia in hearts with preischemic beta-receptor desensitization.
    The Journal of surgical research, 1992, Volume: 53, Issue:1

    Topics: Adenosine Triphosphate; Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Cell Membrane; Hear

1992
Myocardial effects of adrenaline, isoprenaline and dobutamine at hypothermic conditions.
    Pharmacology & toxicology, 1990, Volume: 66, Issue:5

    Topics: Animals; Arrhythmias, Cardiac; Body Temperature; Coronary Circulation; Dobutamine; Electrocardiograp

1990
[Changes in the sensitivity of the alpha 2- and beta 1-adrenoreactive systems during the intensive cooling of rats acclimatized to cold].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1988, Volume: 74, Issue:8

    Topics: Acclimatization; Animals; Clonidine; Cold Temperature; Female; Heart Rate; Hypothermia; Isoprotereno

1988
Angiotensin II-induced hypothermia in rats.
    Journal of applied physiology (Bethesda, Md. : 1985), 1985, Volume: 58, Issue:2

    Topics: Angiotensin II; Animals; Atropine; Atropine Derivatives; Body Temperature Regulation; Captopril; Col

1985
Effect of erythrocyte storage and oxyhemoglobin affinity changes on cardiac function.
    The American journal of physiology, 1985, Volume: 248, Issue:4 Pt 2

    Topics: Animals; Basal Metabolism; Body Temperature; Erythrocytes; Heart; Hypothermia; Isoproterenol; Oxyhem

1985
Depressor response to noradrenaline in hypothermic cats.
    Japanese journal of pharmacology, 1969, Volume: 19, Issue:1

    Topics: Acetazolamide; Acetylcholine; Animals; Atropine; Bicarbonates; Blood Pressure; Calcium; Cats; Depres

1969
Studies upon the mechanism of reserpine-induced arrest in egg transport in the mouse oviduct. II. Comparative effects of some agents with actions on smooth muscle and tissue amines.
    Journal of reproduction and fertility, 1969, Volume: 20, Issue:3

    Topics: Amphetamine; Animals; Atropine; Catecholamines; Chlorpromazine; Ethanolamines; Female; Guanethidine;

1969
[Letter: Hemodynamic disorders during deep and prolonged accidental hypothermia].
    La Nouvelle presse medicale, 1974, Oct-12, Volume: 3, Issue:34

    Topics: Aged; Blood Volume; Bradycardia; Cardiac Catheterization; Cardiac Output; Hemodynamics; Hot Temperat

1974
The effects of pretreatment with reserpine, -methyl-p-tyrosine, or prostaglandin E 1 on adrenergic salivation.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1972, Volume: 140, Issue:3

    Topics: Analysis of Variance; Animals; Body Temperature; Cocaine; Dextroamphetamine; Drug Antagonism; Hot Te

1972
[Accidental toxic hypothermia].
    La Presse medicale, 1970, Jun-13, Volume: 78, Issue:29

    Topics: Adolescent; Adult; Age Factors; Aged; Barbiturates; Blood Circulation; Coma; Female; Heart Arrest; H

1970