Page last updated: 2024-10-29

isoproterenol and Hypersensitivity

isoproterenol has been researched along with Hypersensitivity in 50 studies

Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.

Hypersensitivity: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Research Excerpts

ExcerptRelevanceReference
"Adenosine plasma levels were significantly higher in sensitized than normal animals."5.34In vivo adenosine A(2B) receptor desensitization in guinea-pig airway smooth muscle: implications for asthma. ( Adinolfi, B; Blandizzi, C; Breschi, MC; Calderone, V; Camici, M; Fogli, S; Martinelli, C; Martinotti, E; Nieri, P, 2007)
"Candida is rarely a cause antigen for bronchial asthma."5.30Effects of isoproterenol on IL-2 and cAMP production in peripheral T cells from asthmatic and non-asthmatic subjects sensitive to Candida. ( Aihara, M; Dobashi, K; Horie, T; Iizuka, K; Mori, M; Nakazawa, T, 1999)
"Adenylate cyclase responses to isoproterenol, histamine, 5'-guanylylimidodiphosphate (GppNHp) and NaF were measured in lymphocyte membranes of allergic asthmatic patients and healthy control subjects, just before and 24 h after inhalation challenge with house dust mite allergen or histamine."3.67Specific immunological modulation of lymphocyte adenylate cyclase in asthmatic patients after allergenic bronchial provocation. ( de Monchy, JG; de Vries, K; Kauffman, HF; Koëter, GH; Meurs, H; Timmermans, A, 1986)
"Baseline, postexercise, and postisoproterenol lung function was studied in 27 children, 8 to 18 years of age, with a past history of laryngotracheobronchitis (croup) and in ten children without such a history."3.66Pulmonary function in children with a history of laryngotracheobronchitis. ( Loughlin, GM; Taussig, LM, 1979)
"Adenosine plasma levels were significantly higher in sensitized than normal animals."1.34In vivo adenosine A(2B) receptor desensitization in guinea-pig airway smooth muscle: implications for asthma. ( Adinolfi, B; Blandizzi, C; Breschi, MC; Calderone, V; Camici, M; Fogli, S; Martinelli, C; Martinotti, E; Nieri, P, 2007)
"Candida is rarely a cause antigen for bronchial asthma."1.30Effects of isoproterenol on IL-2 and cAMP production in peripheral T cells from asthmatic and non-asthmatic subjects sensitive to Candida. ( Aihara, M; Dobashi, K; Horie, T; Iizuka, K; Mori, M; Nakazawa, T, 1999)
"This tobacco smoke-induced allergy is probably related to a blockade of adrenergic receptors and not to an immunologic phenomenon."1.26A mechanism for tobacco smoke-induced allergy. ( Doyle, RJ; Keller, KF, 1976)
"The guinea pig's allergic reaction is probably the result of a bronchospasm induced by histamine released in tissue of the airway by a local combination of allergen and antibody."1.25Pharmacological differentiation of allergic and classically conditioned asthma in the guinea pig. ( Braun, EW; Garrison, RG; Justesen, DR; Pendleton, RB, 1970)

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-199044 (88.00)18.7374
1990's5 (10.00)18.2507
2000's1 (2.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
St Georgiev, V1
Carlson, RP2
Van Inwegen, RG1
Khandwala, A1
FIFER, WR1
BALDEK, R1
YOUNG, GC1
BENNIKE, KA1
HAGELSTEN, JO1
SWINEFORD, O1
WESTERVELT, FB1
TULL, LN1
Breschi, MC1
Blandizzi, C1
Fogli, S1
Martinelli, C1
Adinolfi, B1
Calderone, V1
Camici, M1
Martinotti, E1
Nieri, P1
Collins-Williams, C1
Zalesky, C1
Battu, K1
Chambers, MT1
Malo, PE1
Wasserman, MA1
Barrett-Bee, K2
Ashida, Y1
Saijo, T1
Kuriki, H1
Maki, Y1
Shelhamer, JH1
Metcalfe, DD1
Smith, LJ1
Kaliner, M1
Venter, JC1
Fraser, CM1
Soiefer, AI1
Jeffrey, DR1
Strauss, WL1
Charlton, RR1
Greguski, R1
Hirshman, CA1
Peters, J1
Downes, H1
Leon, D1
Lynn, RK1
Butler, J1
Hanifin, JM1
Folco, GC1
Omini, C1
Viganŏ, T1
Iantorno, G1
Berti, F1
Berlin, I1
Grimaldi, A1
Landault, C1
Cesselin, F1
Puech, AJ1
Hartman, DA1
Ochalski, SJ1
Grady, M1
Stevens, PA1
Pyne, S1
Pyne, N1
Aihara, M1
Dobashi, K1
Horie, T1
Iizuka, K1
Nakazawa, T1
Mori, M1
Keller, KF1
Doyle, RJ1
Lichtenstein, LM1
Nagai, H2
Osuga, K1
Koda, A2
Eyre, P1
Holroyde, MC1
El-Azab, J1
Stewart, PB1
Lees, J1
Norn, S1
Geisler, A1
Skov, PS1
Klysner, R1
Weissberg, RM1
Vervloet, D1
Anfosso, F1
Vellieux, P1
Charpin, J1
Ortez, RA1
Seshachalam, D1
Szentivanyi, A1
Boudoulas, H1
Lewis, RP1
Kates, RE1
Dalamangas, G1
Loughlin, GM1
Taussig, LM1
Minette, A1
Barch, GK1
Talbott, MW1
Watanabe-Kohno, S1
Shimizu, T1
Mizuta, J1
Ogino, K1
Yamamura, H1
Ohata, K1
Mukhopadhyay, A1
Miller, DD1
Feller, DR1
Inagaki, N1
Miura, T1
Daikoku, M1
Ohuchi, K1
Hirasawa, N1
Takeda, H1
Asano, K1
Watanabe, M1
Tsurufuji, S1
Meurs, H1
Kauffman, HF1
Timmermans, A1
de Monchy, JG1
Koëter, GH1
de Vries, K1
Assem, ES2
Richter, AW1
Ishizaka, K1
Ishizaka, T1
Passero, MA1
Dees, SC1
Howell, JB1
Altounyan, RE1
Pickup, PM1
Schild, HO1
Kerr, JW1
Silverman, M1
Connolly, NM1
Balfour-Lynn, L1
Godfrey, S1
Selve, H1
Simonsson, BG1
Justesen, DR1
Braun, EW1
Garrison, RG1
Pendleton, RB1
Jack, D1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00005279]0 participants Observational1971-06-30Completed
The Potential Therapeutic Effect of Roflumilust (a Selective Phosphodiesterase 4inhibitor) on Chronic Rhinosinusitis With Nasal Polyposis.[NCT05369039]Phase 260 participants (Anticipated)Interventional2022-06-30Not yet recruiting
Ketotifen as a Treatment for Vascular Leakage During Dengue Fever (KETODEN)[NCT02673840]Phase 4110 participants (Anticipated)Interventional2015-03-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for isoproterenol and Hypersensitivity

ArticleYear
The pluricausal cardiopathies.
    Annals of the New York Academy of Sciences, 1969, Jan-31, Volume: 156, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Antimalarials; Calcinosis; Cardiac Glycosides; Deficiency Diseases;

1969

Trials

4 trials available for isoproterenol and Hypersensitivity

ArticleYear
Suspected postprandial hypoglycemia is associated with beta-adrenergic hypersensitivity and emotional distress.
    The Journal of clinical endocrinology and metabolism, 1994, Volume: 79, Issue:5

    Topics: Adult; Blood Glucose; Blood Pressure; C-Peptide; Catecholamines; Eating; Female; Glucose; Glucose To

1994
A double-blind trial of disodium cromoglycate in the treatment of allergic bronchial asthma.
    Lancet (London, England), 1967, Sep-09, Volume: 2, Issue:7515

    Topics: Adult; Asthma; Benzopyrans; Blood Chemical Analysis; Clinical Trials as Topic; Electrolytes; Female;

1967
Long-term trial of disodium cromoglycate and isoprenaline in children with asthma.
    British medical journal, 1972, Aug-12, Volume: 3, Issue:5823

    Topics: Asthma; Blood Cell Count; Bronchial Diseases; Child; Clinical Trials as Topic; Cromolyn Sodium; Eosi

1972
Clinical and physiological studies on chronic bronchitis. 3. Bronchial reactivity to inhaled acetylcholine.
    Acta allergologica, 1965, Volume: 20, Issue:5

    Topics: Acetylcholine; Adult; Aerosols; Aged; Bronchi; Bronchitis; Clinical Trials as Topic; Female; Humans;

1965

Other Studies

45 other studies available for isoproterenol and Hypersensitivity

ArticleYear
Drug-induced modifications of the immune response. 1. Substituted 1-phenylisoquinolines.
    Journal of medicinal chemistry, 1979, Volume: 22, Issue:4

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Dogs; Guinea Pigs; Histamine Release; Hypersensitivity

1979
ASTHMA IN THE AGED.
    Postgraduate medicine, 1963, Volume: 34

    Topics: Aminophylline; Asthma; Bronchial Spasm; Bronchitis; Desensitization, Immunologic; Diagnosis, Differe

1963
ALLERGY TO INSECT STINGS.
    Applied therapeutics, 1964, Volume: 6

    Topics: Adrenal Cortex Hormones; Anaphylaxis; Anti-Allergic Agents; Desensitization, Immunologic; Drug Thera

1964
A SUSTAINED-RELEASE ANTIHISTAMINE.
    The Practitioner, 1964, Volume: 193

    Topics: Angioedema; Asthma; Conjunctivitis; Delayed-Action Preparations; Drug Hypersensitivity; Drug Therapy

1964
[ALLERGY AND ANESTHESIA].
    Nordisk medicin, 1964, Nov-26, Volume: 72

    Topics: Adrenal Cortex Hormones; Allergens; Anaphylaxis; Anesthesia; Anesthetics; Drug Hypersensitivity; Dru

1964
Prevention of bronchial reactions to aerosols of specific haptens by pretreatment with aerosols of pyribenzamine and isuprel: preliminary report.
    The Journal of allergy, 1955, Volume: 26, Issue:2

    Topics: Aerosols; Biomedical Research; Haptens; Humans; Hypersensitivity; Immune System Diseases; Isoprotere

1955
In vivo adenosine A(2B) receptor desensitization in guinea-pig airway smooth muscle: implications for asthma.
    European journal of pharmacology, 2007, Dec-01, Volume: 575, Issue:1-3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Asthma; Base Sequence; Bronchodilator Agents;

2007
Death from asthma.
    Canadian Medical Association journal, 1981, Aug-15, Volume: 125, Issue:4

    Topics: Acute Disease; Adolescent; Adrenergic beta-Agonists; Adult; Asthma; Child; Child, Preschool; Humans;

1981
The modulation of adrenergic airway tone in normal and ascaris-sensitive beagle dogs.
    European journal of pharmacology, 1982, Dec-17, Volume: 86, Issue:1

    Topics: Adrenergic alpha-Agonists; Animals; Ascaris; Dinoprost; Dogs; Female; Hypersensitivity; In Vitro Tec

1982
Antigen-induced histamine release from sensitized tissue and the measurement of calcium ion fluxes.
    Biochemical and biophysical research communications, 1981, Jan-30, Volume: 98, Issue:2

    Topics: Animals; Antigens; Calcium; Guinea Pigs; Histamine Release; Hypersensitivity; Isoproterenol; Lung; P

1981
Interaction of the antiallergic agent AA-344 with biogenic amines and prostaglandins in production of cyclic AMP in rat mast cells.
    International archives of allergy and applied immunology, 1980, Volume: 62, Issue:4

    Topics: Amines; Animals; Chromones; Cyclic AMP; Drug Synergism; Epinephrine; Histamine; Hypersensitivity; Is

1980
Abnormal beta adrenergic responsiveness in allergic subjects: analysis of isoproterenol-induced cardiovascular and plasma cyclic adenosine monophosphate responses.
    The Journal of allergy and clinical immunology, 1980, Volume: 66, Issue:1

    Topics: Adult; Asthma; Cardiovascular System; Cyclic AMP; Dose-Response Relationship, Immunologic; Female; H

1980
Autoantibodies and monoclonal antibodies to beta-adrenergic receptors: their use in receptor purification and characterization.
    Advances in cyclic nucleotide research, 1981, Volume: 14

    Topics: Animals; Antibodies, Monoclonal; Asthma; Autoantibodies; Chromatography, Affinity; Erythrocyte Membr

1981
Citric acid airway constriction in dogs with hyperreactive airways.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1983, Volume: 54, Issue:4

    Topics: Airway Resistance; Animals; Atropine; Bronchial Provocation Tests; Bronchial Spasm; Citrates; Citric

1983
Pharmacologic control of thromboxane A2 generation in lungs.
    Advances in prostaglandin and thromboxane research, 1980, Volume: 7

    Topics: Animals; Atropine; Guinea Pigs; Histamine; Hypersensitivity; Isoproterenol; Lung; Male; Ovalbumin; P

1980
The effects of anti-inflammatory and antiallergic drugs on the release of IL-1 beta and TNF-alpha in the human whole blood assay.
    Agents and actions, 1993, Volume: 39 Spec No

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Humans; Hypersensitivity; Interle

1993
Adenylyl cyclase in lung from hypersensitive guinea pig displays increased responsiveness to guanine nucleotides and isoprenaline: the role of the G proteins Gs and Gi.
    Biochimica et biophysica acta, 1993, Apr-16, Volume: 1176, Issue:3

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Amino Acid Sequence; Animals; Cells, Cultured; Cholera T

1993
Effects of isoproterenol on IL-2 and cAMP production in peripheral T cells from asthmatic and non-asthmatic subjects sensitive to Candida.
    Biology of the cell, 1999, Volume: 91, Issue:7

    Topics: Asthma; Candida; Case-Control Studies; Concanavalin A; Cyclic AMP; Dose-Response Relationship, Drug;

1999
A mechanism for tobacco smoke-induced allergy.
    The Journal of allergy and clinical immunology, 1976, Volume: 57, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Autonomic Nervous System; Blood Glucose; Epinephrine; Female;

1976
Sequential analysis of the allergic response: cyclic AMP, calcium and histamine.
    International archives of allergy and applied immunology, 1975, Volume: 49, Issue:1-2

    Topics: Animals; Antigen-Antibody Reactions; Binding, Competitive; Bucladesine; Burimamide; Calcimycin; Calc

1975
Inhibition of hypersensitivity reactions by soluble derivatives of baicalein.
    Japanese journal of pharmacology, 1975, Volume: 25, Issue:6

    Topics: Aminophylline; Anaphylaxis; Animals; Antigens; Arthus Reaction; Asthma; Chlorpheniramine; Female; Fl

1975
Atypical adrenergic modulation of allergic histamine release from bovine leucocytes [proceedings].
    British journal of pharmacology, 1976, Volume: 57, Issue:3

    Topics: Animals; Cattle; Epinephrine; Histamine Release; Hypersensitivity; In Vitro Techniques; Isoprotereno

1976
Pharmacologic profile of a new antiallergic compound PRD-92-Ea.
    International archives of allergy and applied immunology, 1977, Volume: 55, Issue:1-6

    Topics: Animals; Asthma; Benzopyrans; Cromolyn Sodium; Disease Models, Animal; Haplorhini; Histamine Release

1977
The nature of the beta-adrenoceptor involved in the inhibition of antigen-induced histamine release.
    Biochemical and biophysical research communications, 1978, Oct-30, Volume: 84, Issue:4

    Topics: Animals; Antigens; Binding, Competitive; Guinea Pigs; Histamine Release; Hypersensitivity; Isoproter

1978
Differentiation between cyclic AMP level and allergic histamine release in mast cells [proceedings].
    Agents and actions, 1979, Volume: 9, Issue:1

    Topics: Animals; Cyclic AMP; Histamine Release; Hypersensitivity; Isoproterenol; Male; Mast Cells; Rats

1979
Conscious primate model for evaluating antiallergic drugs.
    Monographs in allergy, 1979, Volume: 14

    Topics: Albuterol; Animals; Ascaris; Cromolyn Sodium; Disease Models, Animal; Haplorhini; Histamine Release;

1979
Cyclic AMP in hypersensitivity reactions.
    Allergy, 1979, Volume: 34, Issue:6

    Topics: Basophils; Bucladesine; Cyclic AMP; Histamine Release; Humans; Hypersensitivity; Isoproterenol; Phyt

1979
Alterations in adenyl cyclase activity and glucose utilization of Bordetella pertussis-sensitized mouse spleen.
    Biochemical pharmacology, 1975, Jul-15, Volume: 24, Issue:13-14

    Topics: Adenylyl Cyclases; Aminophylline; Animals; Blood Glucose; Bordetella pertussis; Cyclic AMP; Epinephr

1975
Hypersensitivity to adrenergic stimulation after propranolol withdrawal in normal subjects.
    Annals of internal medicine, 1977, Volume: 87, Issue:4

    Topics: Administration, Oral; Adult; Heart Rate; Humans; Hypersensitivity; Isoproterenol; Myocardial Contrac

1977
Pulmonary function in children with a history of laryngotracheobronchitis.
    The Journal of pediatrics, 1979, Volume: 94, Issue:3

    Topics: Adolescent; Child; Croup; Humans; Hypersensitivity; Isoproterenol; Laryngitis; Lung; Physical Exerti

1979
[Epidemiological contribution to the etiology of chronic bronchitis. III. Standardization of methods suitable for the study of bronchial hyperreactivity and allergy in epidemiology].
    Revue de l'Institut d'hygiene des mines, 1976, Volume: 31, Issue:1

    Topics: Acetylcholine; Airway Obstruction; Albuterol; Bronchial Diseases; Bronchitis; Bronchodilator Agents;

1976
Allergic bronchoconstriction and its drug-induced reversal in anesthetized, ovalbumin-sensitized cats.
    Research communications in chemical pathology and pharmacology, 1976, Volume: 13, Issue:4

    Topics: Airway Resistance; Aminophylline; Anesthesia; Animals; Bronchi; Cats; Female; Hypersensitivity; Isop

1976
Effect of procaterol on the isolated airway smooth muscle and the release of anaphylactic chemical mediators from the isolated lung fragments.
    Arzneimittel-Forschung, 1990, Volume: 40, Issue:6

    Topics: Albuterol; Anaphylaxis; Animals; Bronchi; Ethanolamines; Guinea Pigs; Histamine Release; Humans; Hyp

1990
Antiallergic effect of trimetoquinol analogs on actively sensitized guinea pig lung tissue, in vitro.
    Biochemical pharmacology, 1986, Sep-01, Volume: 35, Issue:17

    Topics: Animals; Antigens; Dose-Response Relationship, Drug; Guinea Pigs; Histamine H1 Antagonists; Histamin

1986
Inhibitory effects of beta-adrenergic stimulants on increased vascular permeability caused by passive cutaneous anaphylaxis, allergic mediators, and mediator releasers in rats.
    Pharmacology, 1989, Volume: 39, Issue:1

    Topics: Adrenergic beta-Agonists; Albuterol; Animals; Ascaris; Capillary Permeability; Colforsin; Cyclic AMP

1989
Mechanism of antianaphylactic action of beta-agonists in allergic inflammation of air pouch type in rats.
    International archives of allergy and applied immunology, 1987, Volume: 82, Issue:1

    Topics: Adrenergic beta-Antagonists; Anaphylaxis; Animals; Antibodies, Anti-Idiotypic; Capillary Permeabilit

1987
Specific immunological modulation of lymphocyte adenylate cyclase in asthmatic patients after allergenic bronchial provocation.
    International archives of allergy and applied immunology, 1986, Volume: 81, Issue:3

    Topics: Adenylyl Cyclases; Adolescent; Adult; Allergens; Asthma; Bronchial Provocation Tests; Female; Guanyl

1986
Comparison of in vivo and in vitro inhibition of the anaphylactic mechanism by beta-adrenergic stimulants and disodium cromoglycate.
    Immunology, 1971, Volume: 21, Issue:5

    Topics: Adrenergic beta-Agonists; Amino Alcohols; Anaphylaxis; Animals; Chromones; Dextrans; Female; Guinea

1971
Mechanisms of reaginic hypersensitivity: a review.
    Clinical allergy, 1971, Volume: 1, Issue:1

    Topics: Allergens; Animals; Antigen-Antibody Complex; Antigen-Antibody Reactions; Basophils; Diethylcarbamaz

1971
Disodium cromoglycate.
    Lancet (London, England), 1972, Dec-16, Volume: 2, Issue:7790

    Topics: Adult; Airway Obstruction; Antigen-Antibody Reactions; Asthma; Child; Cromolyn Sodium; Humans; Hyper

1972
Allergy to stings from winged things.
    American family physician, 1973, Volume: 7, Issue:6

    Topics: Adult; Age Factors; Anaphylaxis; Bees; Child; Cross Reactions; Emergencies; Epinephrine; Epitopes; F

1973
The inhibition of allergic reactions by sympathomimetic amines and methylxanthines.
    British journal of pharmacology, 1970, Volume: 39, Issue:1

    Topics: Animals; Antigens; Caffeine; Cyclic AMP; Guinea Pigs; Histamine Release; Humans; Hypersensitivity; I

1970
Bronchial asthma.
    The Practitioner, 1974, Volume: 212, Issue:1269

    Topics: Adrenocorticotropic Hormone; Aerosols; Airway Obstruction; Albuterol; Aminophylline; Antigens; Asthm

1974
Pharmacological differentiation of allergic and classically conditioned asthma in the guinea pig.
    Science (New York, N.Y.), 1970, Nov-20, Volume: 170, Issue:3960

    Topics: Animals; Asthma; Atropine; Conditioning, Classical; Conditioning, Psychological; Diphenhydramine; Gu

1970
Sniffing syndrome.
    British medical journal, 1971, Jun-19, Volume: 2, Issue:5763

    Topics: Aerosols; Amino Alcohols; Animals; Asthma; Bronchodilator Agents; Dogs; Epinephrine; Fluorine; Heart

1971