Page last updated: 2024-10-29

isoproterenol and Glioma

isoproterenol has been researched along with Glioma in 157 studies

Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"The beta-adrenoceptor-coupled adenylate cyclase system in rat C6 glioma cells displays many characteristics observed in brain tissue: using nonlinear regression analysis of agonist competition binding curves, we demonstrated that the bulk of beta-adrenoceptors show high nanomolar affinity for isoproterenol; like in brain tissue, Gpp(NH)p does not shift agonist competition binding curves to the right; and the agonist isoproterenol rapidly downregulates the number of beta-adrenoceptors and deamplifies the norepinephrine signal."7.68The beta-adrenoceptor-coupled adenylate cyclase system in rat C6 glioma cells. Deamplification by isoproterenol and oxaprotiline. ( Bieck, PR; Duhl, DM; Gillespie, DD; Manier, DH; Sulser, F, 1992)
" In the present study, 2-aminopurine, which has been reported to selectively block c-fos gene expression, was used to test the hypothesis that c-fos protein might be involved in the desensitization to catecholamines was observed in 2-aminopurine-treated C6-2B rat glioma cells."7.682-Aminopurine inhibits RNA and protein synthesis and reduces catecholamine desensitization in C6-2B rat glioma cells. ( Brooker, G; DeBernardi, MA, 1992)
"Nano- and micromolar isoproterenol concentrations were compared by studying cyclic AMP, beta-adrenoceptor density and beta 1-adrenoceptor mRNA in rat C6 glioma cells."7.68Dose-dependent down-regulation of beta-adrenoceptors by isoproterenol in rat C6 glioma cells. ( Bieck, PR; Duhl, DM; Eiring, A; Gillespie, DD; Manier, DH; Sulser, F, 1992)
"Evidence is presented that isoproterenol treatment of rat C6 glioma cells, under conditions that increase glioma cell cAMP levels, causes the phosphorylative modification of several RNA polymerase II subunits."7.67Phosphorylation of rat C6 glioma cell DNA-dependent RNA polymerase II in vivo. Identification of phosphorylated subunits and modulation of phosphorylation by isoproterenol and N6,O2'-dibutyryl cyclic AMP. ( Jungmann, RA; Lee, SK; Schweppe, JS, 1984)
"C6 glioma cells respond to beta-adrenergic agonists (isoproterenol) with a transient rise in intracellular cyclic adenosine monophosphate level."7.67Neuroblastoma membranes inhibit isoproterenol-stimulated rise of cAMP in glioma cells. ( de Vellis, J; Wu, DK, 1984)
"When added to intact C6 glioma cells in the micromolar range of concentrations, ADP and ATP induce an inhibition of the isoproterenol-elicited cAMP responses."7.67ADP and, indirectly, ATP are potent inhibitors of cAMP production in intact isoproterenol-stimulated C6 glioma cells. ( Labouesse, J; Merle, M; Pianet, I, 1989)
"Rat glioma C6 cells, cultured in the presence of the tricyclic antidepressant desipramine, lost a significant number of beta-adrenergic receptors in a time- and dose-dependent manner."7.67Effect of the tricyclic antidepressant desipramine on beta-adrenergic receptors in cultured rat glioma C6 cells. ( Finberg, JP; Fishman, PH, 1987)
"Persistent stimulation with isoproterenol of the beta adrenergic receptor located in C6 glioma cell membranes results in a rapid rise in the cyclic AMP content, an activation of soluble cyclic AMP-dependent protein kinase, a translocation of catalytic subunits of the activated protein kinase to the nucleus and a delayed (3--4 hr later) increase of cyclic AMP phosphodiesterase activity and beta-nerve growth factor content."7.66beta Adrenergic receptor-mediated regulation of cyclic nucleotide phosphodiesterase in C6 glioma cells: vinblastine blockade of isoproterenol induction. ( Costa, E; Schwartz, JP, 1980)
"The beta-adrenergic receptor of C6 glioma cells contains a disulfide bridge which can be reduced by dithiothreitol (DTT)."7.66Irreversible inactivation of beta-adrenergic receptors of C6 glioma cells. Synthesis and study of a thiol derivative of propranolol. ( Bockaert, J; Gozlan, H; Homburger, V; Lucas, M; Michelot, R, 1980)
"The mechanism of isoproterenol and N6,O2-dibutyryl adenosine 3':5'-monophosphate (dibutyryl cAMP) induction of lactate dehydrogenase A subunit mRNA (mRNALDH) was investigated in the rat C6 glioma cell line."7.66Cyclic AMP regulation of lactate dehydrogenase. Isoproterenol and N6,O2-dibutyryl cyclic amp increase the rate of transcription and change the stability of lactate dehydrogenase a subunit messenger RNA in rat C6 glioma cells. ( Jungmann, RA; Kelley, DC; Miles, MF; Milkowski, DM, 1983)
"Chronic in vitro treatment of C6 glioma cells with idazoxan did not significantly affect cholera or pertussis toxin catalyzed ribosylation of Gs and Gi/Go in these cells."5.28Idazoxan down-regulates beta-adrenoceptors on C6 glioma cells in vitro. ( Bitran, JA; Chen, G; Gusovsky, F; Manji, HK; Potter, WZ, 1992)
"In this communication, we demonstrate that an increase in intracellular cAMP by 1) addition of dibutyrylic cAMP (dbcAMP), a membrane-permeable cAMP-analogue, or 2) activation of the β-adrenoceptor with (-)-isoproterenol, down regulates the levels of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) mRNA, NPP1 protein and ecto-NPPase activity in rat C6 glioma cells."3.77Cyclic AMP-dependent down regulation of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) in rat C6 glioma. ( Aerts, I; Grobben, B; Slegers, H; Van Ostade, X, 2011)
"Treatment of rat glioma C6 cells with the beta-receptor agonist isoproterenol induces a massive increase in cAMP."3.74Volatile anesthetics affect the morphology of rat glioma C6 cells via RhoA, ERK, and Akt activation. ( Gambaryan, S; Roewer, N; Tas, PW, 2007)
"Previously, we suggested that dioleoyl phosphatidic acid (PA) and lysophosphatidic acid (LPA) increased [Ca(2+)](i) through endogenous LPA receptors coupled to pertussis toxin-sensitive G proteins in rat C6 glioma cells."3.74Dioleoyl phosphatidic acid induces morphological changes through an endogenous LPA receptor in C6 glioma cells. ( Chang, YJ; Im, DS; Jo, JY; Kim, HL; Kim, YL; Kyeok, K, 2008)
" Using RNase protection assays, we have determined that chronic isoproterenol exposure of rat C6 glioma cells results in the accelerated reduction of beta1-AR mRNAs."3.71Agonist-mediated down-regulation of rat beta1-adrenergic receptor transcripts: role of potential post-transcriptional degradation factors. ( Bai, Y; Brewer, G; Kirigiti, P; Li, B; Li, X; Machida, CA; Yang, YF, 2001)
"Exposure of rat C6 glioma cells to the beta-adrenergic receptor agonist isoproterenol potentiates basal and metabotropic glutamate receptor-stimulated phospholipase C activity in rat C6 glioma cells."3.70Cross-talk between beta-adrenergic and metabotropic glutamate receptors in rat C6 glioma cells. ( Albasanz, JL; Fernández, M; Martín, M; Ros, M, 1998)
" Rat C6 glioma cells were stimulated with isoproterenol and the protein lysates were resolved by 2-DGE."3.70Probing for drug-induced multiplex signal transduction pathways using high resolution two-dimensional gel electrophoresis: application to beta-adrenoceptor stimulation in the rat C6 glioma cell. ( Khawaja, XZ; Storm, SM, 1999)
"Incubation of C6 glioma cells in the presence of aminoglutethimide, an inhibitor of cholesterol metabolism, together with either adenosine 3',5'-cyclic monophosphate (cAMP) analogues or agents that increase cAMP synthesis, such as cholera toxin, forskolin, and isoproterenol, stimulated the rate of pregnenolone formation by their isolated mitochondria."3.69Regulation of C6 glioma cell steroidogenesis by adenosine 3',5'-cyclic monophosphate. ( Guarneri, P; Papadopoulos, V, 1994)
"Pretreatment of 1321N1 human astrocytoma cells with exogenously added bacterial phospholipase C (PLC) induced an increase in subsequent stimulation of cyclic AMP accumulation by the beta-adrenergic receptor agonist isoproterenol and by the direct adenylyl cyclase activator forskolin, a phenomenon referred to as sensitization."3.69Modulation of cyclic AMP accumulation in glial cells by exogenous phospholipase C. ( Hoffman, J; Toews, M; Whittle, S, 1996)
"Microtubule disrupter, colchicine, and microtubule stabilizer, taxol, were used to determine whether microtubules play a role in beta-adrenergic receptor mRNA homeostasis and agonist-induced down-regulation in C6 glioma cells."3.69Regulation of beta-adrenergic receptor mRNA in rat C6 glioma cells is sensitive to the state of microtubule assembly. ( Chuang, DM; Fukamauchi, F; Hough, C, 1994)
" Dibutyryl cAMP (dbcAMP) at 1 mM and isoproterenol at 10 microM inhibited MAP kinase activation and DNA synthesis potentiation with bFGF and platelet-derived growth factor to the control level in cultured astrocytes and C6 glioma cells."3.69Cyclic AMP inhibits activation of mitogen-activated protein kinase and cell proliferation in response to growth factors in cultured rat cortical astrocytes. ( Fukunaga, K; Kurino, M; Miyamoto, E; Ushio, Y, 1996)
"The treatment of rat glioma C6 cells with 10 microM isoproterenol (Ipt) for 4 days upregulated the expression of the myelin-associated glycoprotein (MAG) gene by approximately 55-fold over the control value."3.69Transcriptional regulation of myelin associated glycoprotein gene expression by cyclic AMP. ( Konat, GW; Laszkiewicz, I; Wiggins, RC; Ye, P, 1994)
"Adenine nucleotides inhibited isoproterenol- and forskolin-stimulated cyclic AMP accumulation in C6-2B rat glioma cells."3.68Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase. ( Boyer, JL; Chen, XH; Harden, TK; Lazarowski, ER, 1993)
"The beta-adrenoceptor-coupled adenylate cyclase system in rat C6 glioma cells displays many characteristics observed in brain tissue: using nonlinear regression analysis of agonist competition binding curves, we demonstrated that the bulk of beta-adrenoceptors show high nanomolar affinity for isoproterenol; like in brain tissue, Gpp(NH)p does not shift agonist competition binding curves to the right; and the agonist isoproterenol rapidly downregulates the number of beta-adrenoceptors and deamplifies the norepinephrine signal."3.68The beta-adrenoceptor-coupled adenylate cyclase system in rat C6 glioma cells. Deamplification by isoproterenol and oxaprotiline. ( Bieck, PR; Duhl, DM; Gillespie, DD; Manier, DH; Sulser, F, 1992)
"Exposure of C62B rat glioma cells to fresh medium containing fetal bovine serum induced a sensitization of the subsequent ability of isoproterenol and forskolin to stimulate cyclic AMP accumulation, compared to cells exposed to fresh medium without serum."3.68Serum-induced sensitization of cyclic AMP accumulation in C62B rat glioma cells. ( Arneson-Rotert, LJ; Hoffman, JM; Liewer, SA; Toews, ML, 1992)
" In the present study, 2-aminopurine, which has been reported to selectively block c-fos gene expression, was used to test the hypothesis that c-fos protein might be involved in the desensitization to catecholamines was observed in 2-aminopurine-treated C6-2B rat glioma cells."3.682-Aminopurine inhibits RNA and protein synthesis and reduces catecholamine desensitization in C6-2B rat glioma cells. ( Brooker, G; DeBernardi, MA, 1992)
"We used 31P-NMR spectroscopy to investigate the response of living C6 glioma cells to stimulation by a beta-adrenergic agonist, isoproterenol."3.68Beta-adrenergic stimulation of C6 glioma cells: effects of cAMP overproduction on cellular metabolites. A multinuclear NMR study. ( Canioni, P; Labouesse, J; Merle, M; Pianet, I, 1992)
"Nano- and micromolar isoproterenol concentrations were compared by studying cyclic AMP, beta-adrenoceptor density and beta 1-adrenoceptor mRNA in rat C6 glioma cells."3.68Dose-dependent down-regulation of beta-adrenoceptors by isoproterenol in rat C6 glioma cells. ( Bieck, PR; Duhl, DM; Eiring, A; Gillespie, DD; Manier, DH; Sulser, F, 1992)
"Cultures of rat C6 rat glioma cells exhibit a diminished response to isoproterenol and forskolin after being treated with phorbol 12,13-dibutyrate (PDbU)."3.68Regulation of cAMP levels by protein kinase C in C6 rat glioma cells. ( Bressler, JP; Tinsely, P, 1990)
" Using [3H]DHA and unlabeled L-alprenolol, a substantial amount of over 64% specific binding of beta-adrenergic receptor has been identified on the neuroblastoma x glioma hybrid NG108-15 cell, which has been proven to display numerous functional characteristics of intact neurons."3.68Identification and characterization of the beta-adrenergic receptor on neuroblastoma x glioma hybrid NG108-15 cells. ( Cheng, KW; Ghahary, A, 1990)
"C6 glioma cells respond to beta-adrenergic agonists (isoproterenol) with a transient rise in intracellular cyclic adenosine monophosphate level."3.67Neuroblastoma membranes inhibit isoproterenol-stimulated rise of cAMP in glioma cells. ( de Vellis, J; Wu, DK, 1984)
"Exposure of rat glioma C6 cells to either isoproterenol or 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in desensitization of isoproterenol-stimulated adenylate cyclase activity."3.67Phorbol esters and beta-adrenergic agonists mediate desensitization of adenylate cyclase in rat glioma C6 cells by distinct mechanisms. ( Fishman, PH; Kassis, S; Patel, J; Zaremba, T, 1985)
"Evidence is presented that isoproterenol treatment of rat C6 glioma cells, under conditions that increase glioma cell cAMP levels, causes the phosphorylative modification of several RNA polymerase II subunits."3.67Phosphorylation of rat C6 glioma cell DNA-dependent RNA polymerase II in vivo. Identification of phosphorylated subunits and modulation of phosphorylation by isoproterenol and N6,O2'-dibutyryl cyclic AMP. ( Jungmann, RA; Lee, SK; Schweppe, JS, 1984)
"C6 glioma cells possess beta adrenergic receptors coupled with adenylate cyclase which can be irreversibly blocked by bromoacetylaminomethylpindolol (Br-AAM-pindolol), a beta adrenergic antagonist."3.67Beta adrenergic receptor repopulation of C6 glioma cells after irreversible blockade and down regulation. ( Bockaert, J; Gozlan, H; Homburger, V; Lucas, M; Pantaloni, C, 1984)
"The activity of transglutaminase (TGase) was measured in cultured C6 glioma cells after their stimulation by either isoproterenol and isobutyl-methylxanthine or by a serum-containing medium."3.67Activation and de novo synthesis of transglutaminase in cultured glioma cells. ( Bachrach, U; Korner, G, 1985)
"When added to intact C6 glioma cells in the micromolar range of concentrations, ADP and ATP induce an inhibition of the isoproterenol-elicited cAMP responses."3.67ADP and, indirectly, ATP are potent inhibitors of cAMP production in intact isoproterenol-stimulated C6 glioma cells. ( Labouesse, J; Merle, M; Pianet, I, 1989)
"Competition by beta-adrenergic agonists and antagonists for 125I-pindolol binding sites on intact cells (1321N1 human astrocytoma and C62B rat glioma) was measured using short time binding assays as previously described (Toews, M."3.67Agonist-induced changes in beta-adrenergic receptors on intact cells. ( Perkins, JP; Toews, ML, 1984)
"In C6-2B astrocytoma cells the Beta NGF content and secretion rate are increased by isoproterenol activation of beta-adrenergic receptors (Schwartz and Costa, 1977)."3.67Beta-adrenergic receptor regulation of NGF-mRNA content in rat C6-2B glioma cells. ( Costa, E; Dal Toso, R; De Bernardi, MA; Mocchetti, I, 1987)
" This compound devoid of agonist properties, competed for all (3H)-dihydroalprenolol (3H-DHA) binding sites in C6 glioma cell and rat cerebellum membranes."3.67Irreversible blockade of beta-adrenergic receptors with a bromoacetyl derivative of pindolol. ( Bockaert, J; Bouhelal, R; Gozlan, H; Homburger, V; Lucas, M, 1985)
"Agonist treatment of C6-glioma cells induces two altered states in beta-adrenergic receptors, a low affinity for the hydrophilic antagonist CGP-12177 and a low affinity for agonists like isoproterenol."3.67Evidence for the appearance of an uncoupled form of the beta-adrenergic receptor distinct from the internalized receptor. ( Hertel, C; Portenier, M; Staehelin, M, 1986)
"Loss of gonadotropin receptors in murine Leydig tumor cells and of beta-adrenergic receptors in rat glioma C6 cells occurred following exposure of the cells to human chorionic gonadotropin and isoproterenol, respectively."3.67Down-regulation of gonadotropin and beta-adrenergic receptors by hormones and cyclic AMP. ( Fishman, PH; Rebois, RV; Zaremba, T, 1985)
" Treatment of intact L6 myoblasts or C6 glioma cells with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) inactivated beta-adrenergic receptors on membranes prepared from these cells."3.67Turnover of beta 1- and beta 2-adrenergic receptors after down-regulation or irreversible blockade. ( Molinoff, PB; Neve, KA, 1986)
"Rat glioma C6 cells, cultured in the presence of the tricyclic antidepressant desipramine, lost a significant number of beta-adrenergic receptors in a time- and dose-dependent manner."3.67Effect of the tricyclic antidepressant desipramine on beta-adrenergic receptors in cultured rat glioma C6 cells. ( Finberg, JP; Fishman, PH, 1987)
"When exposed to the beta-agonist (-)-isoproterenol, rat glioma C6 cells exhibited a time-and concentration-dependent reduction in isoproterenol responsiveness (desensitization) and a loss of beta-adrenergic receptors (down-regulation)."3.67Desensitization of catecholamine-stimulated adenylate cyclase and down-regulation of beta-adrenergic receptors in rat glioma C6 cells. Role of cyclic AMP and protein synthesis. ( Fishman, PH; Zaremba, TG, 1984)
"Incubation of C6-BU1 glioma cells in the presence of isoproterenol and Ro20-1724--a potent cAMP phosphodiesterase inhibitor--results in a transient increase in intracellular cAMP levels, followed by a rapid efflux of cyclic AMP from the cells into the media."3.67Transient increase in intracellular concentration of adenosine 3':5'-cyclic monophosphate results in morphological and biochemical differentiation of C6 glioma cells in culture. ( Raj, AB; Sharma, SK, 1987)
"The reappearance of beta-adrenergic receptors in C6-glioma cells after desensitization with isoproterenol was studied using the antagonist [3H]CGP-12177."3.66Reappearance of beta-adrenergic receptors after isoproterenol treatment in intact C6-cells. ( Hertel, C; Staehelin, M, 1983)
" The beta-adrenergic receptors of cultured rat C6 glioma cells (2B clone) as assessed by [(125)I]iodohydroxybenzylpindolol binding were decreased 50 and >95% after pretreatment with 8 nM and 1 muM aminobenzylpropranolol, respectively."3.66Quantitative relationship between beta-adrenergic receptor number and physiologic responses as studied with a long-lasting beta-adrenergic antagonist. ( Brooker, G; Linden, J; Terasaki, WL, 1979)
" In two cell lines, C6 glioma and WEHI 7 lymphoma cells, -50% of the cell surface receptors disappear within minutes of incubation of the cells with isoproterenol."3.66Rapid and reversible disappearance of beta-adrenergic cell surface receptors. ( Simons, P; Staehelin, M, 1982)
" Cultured rat glioma C-6 cells, with beta-adrenergic receptors, and human lung WI-38 cells, with prostaglandin receptors, were exposed to catecholamine (isoproterenol) and prostaglandin E1, respectively, while their junctions were probed with microinjected fluorescent-labelled mono-, di-, and triglutamate."3.66Hormonal regulation of cell junction permeability: upregulation by catecholamine and prostaglandin E1. ( Dahl, G; Loewenstein, WR; Radu, A, 1982)
"The beta-adrenergic receptor of C6 glioma cells contains a disulfide bridge which can be reduced by dithiothreitol (DTT)."3.66Irreversible inactivation of beta-adrenergic receptors of C6 glioma cells. Synthesis and study of a thiol derivative of propranolol. ( Bockaert, J; Gozlan, H; Homburger, V; Lucas, M; Michelot, R, 1980)
"The mechanism of isoproterenol and N6,O2-dibutyryl adenosine 3':5'-monophosphate (dibutyryl cAMP) induction of lactate dehydrogenase A subunit mRNA (mRNALDH) was investigated in the rat C6 glioma cell line."3.66Cyclic AMP regulation of lactate dehydrogenase. Isoproterenol and N6,O2-dibutyryl cyclic amp increase the rate of transcription and change the stability of lactate dehydrogenase a subunit messenger RNA in rat C6 glioma cells. ( Jungmann, RA; Kelley, DC; Miles, MF; Milkowski, DM, 1983)
"17) activity has been studied by using as a model the isoproterenol stimulation of cyclic AMP phosphodiesterase activity in C6 glioma cells."3.66Regulation by a beta-adrenergic receptor of a Ca2+-independent adenosine 3',5'-(cyclic)monophosphate phosphodiesterase in C6 glioma cells. ( Costa, E; Hanbauer, I; Onali, P; Schwartz, JP, 1981)
"Persistent stimulation with isoproterenol of the beta adrenergic receptor located in C6 glioma cell membranes results in a rapid rise in the cyclic AMP content, an activation of soluble cyclic AMP-dependent protein kinase, a translocation of catalytic subunits of the activated protein kinase to the nucleus and a delayed (3--4 hr later) increase of cyclic AMP phosphodiesterase activity and beta-nerve growth factor content."3.66beta Adrenergic receptor-mediated regulation of cyclic nucleotide phosphodiesterase in C6 glioma cells: vinblastine blockade of isoproterenol induction. ( Costa, E; Schwartz, JP, 1980)
"Incubation of C6 glioma cells with isoproterenol elicits an increase in cyclic AMP content, followed by an activation of cyclic AMP-dependent protein kinase (ATP:protein phosphotransferase, EC 2."3.66Protein kinase translocation following beta-adrenergic receptor activation in C6 glioma cells. ( Costa, E; Schwartz, JP, 1980)
" In the present study, however, changes in intracellular cyclic AMP level in several lines of cultured cells (normal 3T3 and SV40 and polyomavirus-transformed 3T3 cells; 3T6, C6 GLIOMA, MOUSE L, and Novikoff rat hepatoma cells) by treatment with papaverine, prostaglandine E1 or isoproterenol did not correlate with the inhibition of the uridine, hypoxanthine or deoxyglucose transport rates by these chemicals."3.65Cyclic AMP, membrane transport and cell division. I. Effects of various chemicals on cyclic AMP levels and rate of transport of neucleosides, hypoxanthine and deoxyglucose in several lines of cultured cells. ( Plagemann, PG; Sheppard, JR, 1975)
" When C6 glioma cells were incubated with mycophenolic acid, a potent and specific inhibitor of IMP:NAD oxidoreductase (EC 1."3.65Reduction in beta-adrenergic response of cultured glioma cells following depletion of intracellular GTP. ( Franklin, TJ; Twose, PA, 1977)
" Each antagonist alone caused smaller shifts to the right in the dose-response curve to NE and, when present simultaneously, completely abolished the NE response."1.29Inducible expression of beta 1- and beta 2-adrenergic receptors in rat C6 glioma cells: functional interactions between closely related subtypes. ( Esbenshade, TA; Guerrero, SW; Minneman, KP; Zhong, H, 1996)
"Isoproterenol treatment of C6 cells altered beta 1 AR mRNA levels in a biphasic manner; i."1.29Agonist and cyclic AMP-mediated regulation of beta 1-adrenergic receptor mRNA and gene transcription in rat C6 glioma cells. ( Duman, RS; Feussner, GK; Fishman, PH; Hosoda, K; Rydelek-Fitzgerald, L, 1994)
"Chronic in vitro treatment of C6 glioma cells with idazoxan did not significantly affect cholera or pertussis toxin catalyzed ribosylation of Gs and Gi/Go in these cells."1.28Idazoxan down-regulates beta-adrenoceptors on C6 glioma cells in vitro. ( Bitran, JA; Chen, G; Gusovsky, F; Manji, HK; Potter, WZ, 1992)
"Pre-treatment with isoproterenol or the cyclic AMP analogue, dibutyryl cyclic AMP, induced refractoriness to forskolin."1.27Forskolin-stimulated cyclic AMP accumulation mediates protein synthesis-dependent refractoriness in C6-2B rat glioma cells. ( Barovsky, K; Brooker, G; Pedone, C, 1983)
"Rat C 6 glioma is known to possess a beta-adrenergic receptor with which intracellular cyclic adenosine monophosphate (cAMP) levels are altered to control cell growth in vitro."1.27[Treatment of rat glioma with a beta-adrenergic agonist and a phosphodiesterase inhibitor in vivo]. ( Egawa, T; Hayakawa, T; Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1987)
" Computer-assisted analysis of dose-response curves resulting from the inhibition of the binding of [125I]iodopindolol by the beta-1 and beta-2 selective compounds ICI 89,406 and ICI 118,551 revealed that approximately one-third of the beta adrenergic receptors on these cells were beta-1 receptors."1.27Selective regulation of beta-1 and beta-2 adrenergic receptors by atypical agonists. ( Barrett, DA; Molinoff, PB; Neve, KA, 1985)
"Isoprenaline treatment of C6-glioma cells induced a fast decrease in the number of beta-adrenergic receptors as determined by binding of [3H]CGP-12177, which paralleled the decrease in the hormonally stimulated adenylate cyclase activity."1.27Determination of the desensitization of beta-adrenergic receptors by [3H]CGP-12177. ( Hertel, C; Müller, P; Portenier, M; Staehelin, M, 1983)

Research

Studies (157)

TimeframeStudies, this research(%)All Research%
pre-199089 (56.69)18.7374
1990's53 (33.76)18.2507
2000's12 (7.64)29.6817
2010's3 (1.91)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Adejare, A1
Nie, JY1
Hebel, D1
Brackett, LE1
Choi, O1
Gusovsky, F2
Padgett, WL1
Daly, JW1
Creveling, CR1
Kirk, KL1
Wnorowski, A1
Such, J1
Paul, RK1
Wersto, RP1
Indig, FE1
Jozwiak, K1
Bernier, M1
Wainer, IW1
Malchinkhuu, E1
Sato, K1
Maehama, T1
Ishiuchi, S1
Yoshimoto, Y1
Mogi, C1
Kimura, T1
Kurose, H1
Tomura, H1
Okajima, F1
Aerts, I1
Grobben, B3
Van Ostade, X1
Slegers, H3
Obara, Y1
Yanagihata, Y1
Abe, T1
Dafik, L1
Ishii, K1
Nakahata, N1
Higashida, H3
Hossain, KZ1
Takahagi, H1
Noda, M1
Ribas, C1
Takesono, A1
Sato, M1
Hildebrandt, JD1
Lanier, SM1
Morita, K1
Arimochi, H1
Itoh, H1
Her, S1
Sokolowska, P1
Nowak, JZ1
Tas, PW2
Gambaryan, S1
Roewer, N1
Chang, YJ1
Kim, YL1
Jo, JY1
Kyeok, K1
Kim, HL1
Im, DS1
Kassis, S3
Fishman, PH11
Lee, SK1
Schweppe, JS4
Jungmann, RA8
Homburger, V6
Pantaloni, C1
Lucas, M7
Gozlan, H4
Bockaert, J7
Hertel, C6
Affolter, H1
Portenier, M4
Staehelin, M7
Müller, P2
Browning, ET1
Nicklas, WJ1
Toews, ML3
Perkins, JP3
Koschel, K3
Derda, DF2
Miles, MF4
Barovsky, K1
Pedone, C1
Brooker, G5
Zaremba, TG1
Schwartz, JP8
Costa, E5
Michelot, R1
Arenander, AT1
de Vellis, J3
Cantau, B1
Barabe, J1
Penit, J2
Chelmicka-Schorr, E2
Arnason, BG2
Holshouser, SJ1
Onali, P2
Hanbauer, I1
Hung, P1
Dibner, MD1
Insel, PA1
Mallorga, P2
Tallman, JF2
Katada, T1
Amano, T1
Ui, M1
Miki, N1
Tanaka, T1
Kato, K2
Nakano, T1
Nagatsu, T1
Kano-Tanaka, K1
Harrison, JJ2
Schwoch, G1
Shitara, N2
McKeever, PE2
Cummins, C1
Smith, BH2
Kornblith, PL2
Hirata, F1
Kelley, DC2
Milkowski, DM1
Milkowski, D1
Radu, A1
Dahl, G1
Loewenstein, WR1
Frederich, RC1
Waldo, GL1
Harden, TK2
Wu, DK1
Antonow, JA1
Bhat, N1
Volpe, JJ1
Sportiello, MG1
Atweh, SF1
Reisine, TD1
Nakamura, H1
Fujiwara, M1
Simons, P1
Hashimoto, S1
Guroff, G1
Lee, S1
Suter, P1
Suter, S1
Sernia, C1
Thomas, WG1
Ye, P2
Laszkiewicz, I2
Wiggins, RC2
Konat, GW1
Tamir, M1
Kushner, L1
Adie, EJ1
Milligan, G3
Miller, T1
Curran, PK2
Feussner, GK2
Chen, J1
Rasenick, MM3
Hough, C2
Fukamauchi, F1
Chuang, DM3
Hosoda, K1
Rydelek-Fitzgerald, L1
Duman, RS2
Kim, GD2
Kreps, DM1
Whittle, SM1
Hoffman, JM2
Boyer, JL1
Lazarowski, ER1
Chen, XH1
Papadopoulos, V1
Guarneri, P1
Lin, WW1
Levi, G1
Patrizio, M1
Bernardo, A1
Petrucci, TC1
Agresti, C1
Debernardi, MA3
Munshi, R1
Orlandi, PA1
Watanabe, M1
Saito, T1
McCrea, KE1
Hill, SJ1
Streich, S1
Brüss, M1
Bönisch, H1
Zhong, H2
Guerrero, SW2
Esbenshade, TA1
Minneman, KP2
Colangelo, AM1
Pani, L1
Mocchetti, I2
Fitzgerald, LR1
Li, Z1
Machida, CA2
Hoffman, J1
Whittle, S1
Toews, M1
MacEwan, DJ1
Kurino, M1
Fukunaga, K1
Ushio, Y2
Miyamoto, E1
Canova, C1
Baudet, C1
Chevalier, G1
Brachet, P1
Wion, D1
Schömig, E1
Russ, H1
Staudt, K1
Martel, F1
Gliese, M1
Gründemann, D1
Martín, M1
Albasanz, JL1
Fernández, M1
Ros, M1
Zumwalt, JW1
Thunstrom, BJ1
Spangelo, BL1
Bergström, D1
Jacobsson, SO1
Fowler, CJ1
Storm, SM1
Khawaja, XZ1
Yang, X1
Wand, G1
Slamon, ND1
Pentreath, VW1
Roymans, D2
Willems, R1
Vissenberg, K1
De Jonghe, C1
Claes, P2
Lascu, I1
Van Bockstaele, D1
Verbelen, JP1
Van Broeckhoven, C1
Kirigiti, P1
Bai, Y1
Yang, YF1
Li, X1
Li, B1
Brewer, G1
Schmitt, H1
Pochet, R1
Franklin, TJ3
Twose, PA3
McCarthy, KD1
Terasaki, WL1
Linden, J1
Sheppard, JR1
Plagemann, PG1
Traber, J1
Reiser, G1
Fischer, K1
Hamprecht, B1
Bachrach, U3
Edström, A1
Kanje, M2
Löfgren, P1
Walum, E1
Venter, BR1
Venter, JC2
Kaplan, NO2
Halbach, M1
Lazarewicz, JW1
Sellström, A1
Hamberger, A1
Yin, J1
Howells, RD1
Bieck, PR2
Duhl, DM2
Eiring, A1
Gillespie, DD2
Manier, DH2
Sulser, F2
Pianet, I3
Canioni, P1
Labouesse, J5
Merle, M3
Gubits, RM2
Yu, H2
Casey, G1
Munell, F1
Vitek, MP1
Valeins, H2
Manji, HK1
Chen, G1
Bitran, JA1
Potter, WZ1
Kanoh, M1
Zhu, W1
Royland, JE1
Konat, G1
Liewer, SA1
Arneson-Rotert, LJ1
Tao-Cheng, JH1
Bressler, JP2
Brightman, MW1
Magnusson, Y1
Wallukat, G1
Guillet, JG1
Hjalmarson, A1
Hoebeke, J1
Seki, T1
Henderson, GB1
Strauss, BP1
Donta, ST1
Shanley, JD1
Tinsely, P1
Ghahary, A1
Cheng, KW1
Korner, G1
Passaquin, AC1
Coupin, G1
Poindron, P1
Conroy, WG1
Peoples, RW1
Isom, GE1
Volker, TT1
Teissié, J1
Hirschfeld, A1
Bressler, J1
Reggiani, A1
Carenzi, A1
Della Bella, D1
Yoshida, T1
Shimizu, K1
Hayakawa, T1
Mogami, H1
Sakamoto, Y1
Egawa, T1
Volker, T1
Viratelle, O1
Dal Toso, R1
De Bernardi, MA1
Bouhelal, R1
Zaremba, T2
Patel, J1
Neve, KA2
Barrett, DA1
Molinoff, PB2
Lauter, CJ1
Stojanov, M1
Salem, N1
Rebois, RV1
McKenzie, RC1
Gillespie, CS1
Brophy, PJ1
Finberg, JP1
Sharma, SK1
Raj, AB1
Kaplan, RS1
Sano, M1
Passonneau, JV1
Dixon, JE1
Maroko, PR1
Gilman, AG2
Minna, JD1
Jard, S1
Benda, P1
Nirenberg, M1

Reviews

1 review available for isoproterenol and Glioma

ArticleYear
Agonist regulation of cellular levels of the stimulatory guanine nucleotide-binding protein, Gs, in wild type and transfected neuroblastoma-glioma hybrid NG108-15 cells.
    Biochemical Society transactions, 1993, Volume: 21, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Down-Regulation; Glioma; GTP-Binding Proteins

1993

Other Studies

156 other studies available for isoproterenol and Glioma

ArticleYear
Effect of fluorine substitution on the adrenergic properties of 3-(tert-butylamino)-1-(3,4-dihydroxyphenoxy)-2-propanol.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:3

    Topics: Adrenergic beta-Agonists; Animals; Cell Membrane; Cerebral Cortex; Chemical Phenomena; Chemistry; Cy

1991
Concurrent activation of β
    Cellular signalling, 2017, Volume: 36

    Topics: Animals; Apoptosis; Brain Neoplasms; Carcinogenesis; Cell Cycle; Cell Line, Tumor; Cell Movement; Ce

2017
Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid--induced migration by isoproterenol in glioma cells.
    Molecular biology of the cell, 2009, Volume: 20, Issue:24

    Topics: Cell Movement; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Glioma; Humans;

2009
Cyclic AMP-dependent down regulation of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) in rat C6 glioma.
    European journal of pharmacology, 2011, Mar-01, Volume: 654, Issue:1

    Topics: Animals; Bucladesine; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Down-Regulation

2011
Gα(h)/transglutaminase-2 activity is required for maximal activation of adenylylcyclase 8 in human and rat glioma cells.
    Cellular signalling, 2013, Volume: 25, Issue:3

    Topics: Adenylyl Cyclases; Amino Acid Substitution; Animals; Cell Line, Tumor; Colforsin; Cyclic AMP; Enzyme

2013
Measurement of adenylyl cyclase by separating cyclic AMP on silica gel thin-layer chromatography.
    Analytical biochemistry, 2002, Sep-01, Volume: 308, Issue:1

    Topics: Adenylyl Cyclases; Animals; Autoradiography; Cholera Toxin; Chromatography, Thin Layer; Cyclic AMP;

2002
Pertussis toxin-insensitive activation of the heterotrimeric G-proteins Gi/Go by the NG108-15 G-protein activator.
    The Journal of biological chemistry, 2002, Dec-27, Volume: 277, Issue:52

    Topics: Animals; Brain; Carrier Proteins; Cattle; Cell Line; Cell Membrane; Colforsin; Glioma; GTP-Binding P

2002
Possible involvement of 5alpha-reduced neurosteroids in adrenergic and serotonergic stimulation of GFAP gene expression in rat C6 glioma cells.
    Brain research, 2006, Apr-26, Volume: 1085, Issue:1

    Topics: 20-alpha-Dihydroprogesterone; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adrenergic beta-Agonists; Analy

2006
Cyclic AMP formation in C6 glioma cells: effect of PACAP and VIP in early and late passages.
    Annals of the New York Academy of Sciences, 2006, Volume: 1070

    Topics: Animals; Cell Line, Tumor; Cellular Senescence; Colforsin; Cyclic AMP; Glioma; Isoproterenol; Pituit

2006
Volatile anesthetics affect the morphology of rat glioma C6 cells via RhoA, ERK, and Akt activation.
    Journal of cellular biochemistry, 2007, Oct-01, Volume: 102, Issue:2

    Topics: Adrenergic beta-Agonists; Amides; Anesthetics, Inhalation; Animals; Cell Line, Tumor; Cell Shape; Cu

2007
Dioleoyl phosphatidic acid induces morphological changes through an endogenous LPA receptor in C6 glioma cells.
    Archives of pharmacal research, 2008, Volume: 31, Issue:5

    Topics: Animals; Cell Line, Tumor; Cell Survival; Cytotoxins; Drug Partial Agonism; Glioma; Isoproterenol; I

2008
Functional alteration of the beta-adrenergic receptor during desensitization of mammalian adenylate cyclase by beta-agonists.
    Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:21

    Topics: Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; Drug Tolerance; Friend murine leukemia virus;

1984
Phosphorylation of rat C6 glioma cell DNA-dependent RNA polymerase II in vivo. Identification of phosphorylated subunits and modulation of phosphorylation by isoproterenol and N6,O2'-dibutyryl cyclic AMP.
    The Journal of biological chemistry, 1984, Dec-10, Volume: 259, Issue:23

    Topics: Amino Acids; Animals; Bucladesine; Cell Line; Electrophoresis, Polyacrylamide Gel; Glioma; Isoproter

1984
Beta adrenergic receptor repopulation of C6 glioma cells after irreversible blockade and down regulation.
    Journal of cellular physiology, 1984, Volume: 121, Issue:3

    Topics: Cells, Cultured; Cycloheximide; Glioma; Isoproterenol; Nerve Block; Pindolol; Receptors, Adrenergic,

1984
Desensitized beta-adrenoceptors of C6-glioma cells have distinct binding properties.
    Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 328, Issue:1

    Topics: Animals; Cell Line; Cell Membrane; Glioma; Guanosine Triphosphate; Isoproterenol; Rats; Receptors, A

1984
Some unique properties of CGP-12177.
    Journal of receptor research, 1984, Volume: 4, Issue:1-6

    Topics: Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Digitonin; Dihydroalprenolol; Glioma; Isoproteren

1984
Induction of glutamine synthetase by dibutyryl cyclic AMP in C-6 glioma cells.
    Journal of neurochemistry, 1982, Volume: 39, Issue:2

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Cell Division; Cell Line; Cyclic AMP;

1982
Turn on and turn off reactions of beta-adrenergic-sensitive adenylate cyclase in control and desensitized C6 glioma cells.
    FEBS letters, 1982, May-17, Volume: 141, Issue:2

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Cell Line; Dihydroalprenolol; Enzyme Activatio

1982
Reappearance of beta-adrenergic receptors after isoproterenol treatment in intact C6-cells.
    The Journal of cell biology, 1983, Volume: 97, Issue:5 Pt 1

    Topics: Adrenergic beta-Antagonists; Animals; Cations; Cell Line; Cycloheximide; Glioma; Isoproterenol; Kine

1983
Determination of the desensitization of beta-adrenergic receptors by [3H]CGP-12177.
    The Biochemical journal, 1983, Dec-15, Volume: 216, Issue:3

    Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Binding Sites; Binding, Competitive; Cell Line; Cell

1983
Agonist-induced changes in beta-adrenergic receptors on intact cells.
    The Journal of biological chemistry, 1984, Feb-25, Volume: 259, Issue:4

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytoma; Binding, Competitive; C

1984
A hormone-independent rise of adenosine 3',5'-monophosphate desensitizes coupling of beta-adrenergic receptors to adenylate cyclase in rat glioma C6-cells.
    European journal of biochemistry, 1980, Volume: 108, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Carrier Proteins; Cholera Toxin; Cyclic AMP

1980
Cyclic AMP regulation of lactate dehydrogenase. Isoproterenol and N6,O2'-dibutyryl cyclic AMP increase the levels of lactate dehydrogenase-5 isozyme and its messenger RNA in rat C6 glioma cells.
    The Journal of biological chemistry, 1980, Dec-10, Volume: 255, Issue:23

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Line; Cyclic AMP; Dactinomycin; Glioma; Half

1980
Forskolin-stimulated cyclic AMP accumulation mediates protein synthesis-dependent refractoriness in C6-2B rat glioma cells.
    Journal of cyclic nucleotide and protein phosphorylation research, 1983, Volume: 9, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Cyclohexi

1983
Desensitization of catecholamine-stimulated adenylate cyclase and down-regulation of beta-adrenergic receptors in rat glioma C6 cells. Role of cyclic AMP and protein synthesis.
    Molecular pharmacology, 1984, Volume: 26, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bucladesine; Cell Line; Cell Membrane; Chol

1984
Protein kinase translocation following beta-adrenergic receptor activation in C6 glioma cells.
    The Journal of biological chemistry, 1980, Apr-10, Volume: 255, Issue:7

    Topics: Animals; Cell Line; Cyclic AMP; Cytosol; Glioma; Isoproterenol; Kinetics; Protamine Kinase; Protein

1980
beta Adrenergic receptor-mediated regulation of cyclic nucleotide phosphodiesterase in C6 glioma cells: vinblastine blockade of isoproterenol induction.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 212, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Line; Cyclic AMP; Enzyme Induction; Glioma; Isopr

1980
Irreversible inactivation of beta-adrenergic receptors of C6 glioma cells. Synthesis and study of a thiol derivative of propranolol.
    Biochimie, 1980, Volume: 62, Issue:7

    Topics: Adenylyl Cyclases; Animals; Cell Line; Dithiothreitol; Ethylmaleimide; Glioma; Isoproterenol; Kineti

1980
Glial-released proteins in clonal cultures and their modulation by hydrocortisone.
    Brain research, 1980, Nov-03, Volume: 200, Issue:2

    Topics: Animals; Bucladesine; Cell Line; Estradiol; Glioma; Hydrocortisone; Isoproterenol; Melatonin; Molecu

1980
Further evidence that desensitization of beta-adrenergic-sensitive adenylate cyclase proceeds in two steps. Modification of the coupling and loss of beta-adrenergic receptors.
    The Journal of biological chemistry, 1980, Nov-10, Volume: 255, Issue:21

    Topics: Adenylyl Cyclases; Animals; Cell Line; Cycloheximide; Dihydroalprenolol; Enzyme Activation; Glioma;

1980
C-6 glioma growth in rats: suppression with a beta-adrenergic agonist and a phosphodiesterase inhibitor.
    Annals of neurology, 1980, Volume: 8, Issue:4

    Topics: Animals; Brain Neoplasms; Cell Line; Cyclic AMP; Drug Therapy, Combination; Glioma; Humans; Isoprote

1980
Regulation by a beta-adrenergic receptor of a Ca2+-independent adenosine 3',5'-(cyclic)monophosphate phosphodiesterase in C6 glioma cells.
    Biochimica et biophysica acta, 1981, Volume: 675, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 8-Bromo Cyclic Adenosine M

1981
Cyclic AMP regulation of lactate dehydrogenase. Quantitation of lactate dehydrogenase M-subunit messenger RNA in isoproterenol-and N6,O2'-dibutyryl cyclic AMP-stimulated rat C6 glioma cells by hybridization analysis using a cloned cDNA probe.
    The Journal of biological chemistry, 1981, Dec-10, Volume: 256, Issue:23

    Topics: Animals; Bucladesine; Cell Line; Cloning, Molecular; Cyclic AMP; DNA Restriction Enzymes; DNA, Recom

1981
Growth of C6 glioma cells in serum-containing medium decreases beta-adrenergic receptor number.
    Journal of cellular physiology, 1981, Volume: 109, Issue:2

    Topics: Animals; Blood; Cell Line; Cell Separation; Culture Media; Cyclic AMP; Glioma; Isoproterenol; Rats;

1981
Catecholamine-induced desensitization of adenylate cyclase in rat glioma C6 cells. Evidence for a specific uncoupling of beta-adrenergic receptors from a functional regulatory component of adenylate cyclase.
    Molecular pharmacology, 1981, Volume: 20, Issue:2

    Topics: Adenylyl Cyclases; Animals; Catecholamines; Cells, Cultured; Cholera Toxin; Dihydroalprenolol; Gliom

1981
Differences in the beta-adrenergic responsiveness between high and low passage rat glioma C6 cells.
    Biochimica et biophysica acta, 1981, Dec-04, Volume: 678, Issue:2

    Topics: Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; Cholera Toxin; Cyclic AMP; Dihydroalprenolol;

1981
RNA polymerase II in C6 glioma cells. Alpha-amanitin blockade of cAMP phosphodiesterase induction by beta-adrenergic stimulation.
    Experimental cell research, 1982, Volume: 137, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amanitins; Animals; Cell Line; Cell Nucleus; Cyclic AMP; Dactin

1982
Modulation by islet-activating protein of adenylate cyclase activity in C6 glioma cells.
    The Journal of biological chemistry, 1982, Apr-10, Volume: 257, Issue:7

    Topics: Adenine Nucleotides; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Bacterial Proteins; Calciu

1982
Receptor-associated changes of the catecholamine-sensitive adenylate cyclase in glioma cells doubly transformed with Moloney sarcoma virus.
    Journal of cellular physiology, 1982, Volume: 110, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine Triphosphate; Adenylyl Cyclases; Animals; Cell Transf

1982
Photoaffinity labelling of beta-adrenergic receptors of C6 glioma cells. Presence of a nucleophilic group in the receptor.
    Biochemical pharmacology, 1982, Sep-15, Volume: 31, Issue:18

    Topics: Adenylyl Cyclases; Affinity Labels; Animals; Cell Membrane; Cells, Cultured; Darkness; Glioma; Isopr

1982
Phosphorylative modification of histone H1 subspecies following isoproterenol and N6,O2'-dibutyryl cyclic AMP stimulation of rat C6 glioma cells.
    The Journal of biological chemistry, 1982, Nov-25, Volume: 257, Issue:22

    Topics: Amino Acids; Animals; Bucladesine; Cell Line; Cyclic AMP; Glioma; Histones; Isoproterenol; Neoplasms

1982
beta-Adrenergic receptor desensitization stimulates glucose uptake in C6 rat glioma cells.
    Biochemical and biophysical research communications, 1982, Dec-15, Volume: 109, Issue:3

    Topics: Animals; Biological Transport, Active; Cell Line; Cyclic AMP; Deoxy Sugars; Deoxyglucose; Epinephrin

1982
Cyclic AMP regulation of lactate dehydrogenase. Isoproterenol and N6,O2-dibutyryl cyclic amp increase the rate of transcription and change the stability of lactate dehydrogenase a subunit messenger RNA in rat C6 glioma cells.
    The Journal of biological chemistry, 1983, Apr-25, Volume: 258, Issue:8

    Topics: Animals; Bucladesine; Cell Line; Cyclic AMP; Glioma; Isoproterenol; L-Lactate Dehydrogenase; Rats; R

1983
Regulation of lactate dehydrogenase gene expression.
    Isozymes, 1983, Volume: 7

    Topics: Animals; Cell Line; Cyclic AMP; Genes; Glioma; Isoenzymes; Isoproterenol; Kinetics; L-Lactate Dehydr

1983
Hormonal regulation of cell junction permeability: upregulation by catecholamine and prostaglandin E1.
    The Journal of membrane biology, 1982, Volume: 70, Issue:3

    Topics: Alprostadil; Animals; Cell Communication; Cell Membrane Permeability; Cells, Cultured; Cyclic AMP; G

1982
Characterization of agonist-induced beta-adrenergic receptor-specific desensitization in C62B glioma cells.
    Journal of cyclic nucleotide and protein phosphorylation research, 1983, Volume: 9, Issue:2

    Topics: Adenylyl Cyclases; Animals; Astrocytoma; Catecholamines; Cells, Cultured; Centrifugation, Density Gr

1983
Evidence for intravesicular beta-adrenergic receptors in membrane fractions from desensitized cells: binding of the hydrophilic ligand CGP-12177 only in the presence of alamethicin.
    Journal of cyclic nucleotide and protein phosphorylation research, 1983, Volume: 9, Issue:2

    Topics: Alamethicin; Animals; Anti-Bacterial Agents; Cells, Cultured; Centrifugation, Density Gradient; Glio

1983
Neuroblastoma membranes inhibit isoproterenol-stimulated rise of cAMP in glioma cells.
    Journal of cellular physiology, 1984, Volume: 118, Issue:3

    Topics: Animals; Cell Fractionation; Cell Membrane; Cells, Cultured; Cyclic AMP; Glioma; Isoproterenol; Neur

1984
Cytoskeletal structures and oligodendroglial differentiation in C-6 glial cells.
    Journal of neurochemistry, 1984, Volume: 42, Issue:4

    Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; B

1984
Response of C-6 glioma to isoproterenol and papaverine in vivo depends on beta-adrenergic receptor density.
    Annals of neurology, 1984, Volume: 15, Issue:1

    Topics: Animals; Cells, Cultured; Glioma; In Vitro Techniques; Isoproterenol; Neoplasm Transplantation; Neop

1984
The beta-adrenergic receptor system in human glioma-derived cell lines: the mode of phosphodiesterase induction and the macromolecules phosphorylated by cyclic AMP-dependent protein kinase.
    Brain research, 1984, Mar-26, Volume: 296, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Cytosol; Dih

1984
Rapid and reversible disappearance of beta-adrenergic cell surface receptors.
    The EMBO journal, 1982, Volume: 1, Issue:2

    Topics: Animals; Cell Line; Endocytosis; Glioma; Isoproterenol; Lymphoma; Propanolamines; Receptors, Adrener

1982
Beta-adrenergic receptor regulation of a cyclic AMP phosphodiesterase in C6 glioma cells.
    Advances in cyclic nucleotide and protein phosphorylation research, 1984, Volume: 16

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Amanitins; Animals; Cell Line; Cyclic AMP; D

1984
Norepinephrine and nerve growth factor: similar proteins phosphorylated in the nuclei of target cells.
    Biochemical and biophysical research communications, 1982, Feb-26, Volume: 104, Issue:4

    Topics: Animals; Cell Line; Chromosomal Proteins, Non-Histone; Ganglia, Sympathetic; Glioma; Isoproterenol;

1982
Isoproterenol-induced selective phosphorylation in vivo of the 214,000 dalton subunit of rat C6 glioma cell RNA polymerase II.
    Biochemical and biophysical research communications, 1981, Sep-16, Volume: 102, Issue:1

    Topics: Animals; Cell Line; DNA-Directed RNA Polymerases; Glioma; Isoproterenol; Macromolecular Substances;

1981
Isoproterenol-induced selective phosphorylative modification in vivo of rat C6 glioma cell histones.
    Biochemical and biophysical research communications, 1980, Oct-16, Volume: 96, Issue:3

    Topics: Animals; Cell Line; Glioma; Histones; Isoproterenol; Neoplasm Proteins; Neoplasms, Experimental; Pho

1980
A novel inhibitory role for glucocorticoids in the secretion of angiotensinogen by C6 glioma cells.
    Journal of neurochemistry, 1994, Volume: 62, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Angiotensinogen; Animals; Bucladesine; Cyclic AMP; Dexamet

1994
Transcriptional regulation of myelin associated glycoprotein gene expression by cyclic AMP.
    Journal of neuroscience research, 1994, Apr-15, Volume: 37, Issue:6

    Topics: Animals; Blotting, Northern; Choline O-Acetyltransferase; Cyclic AMP; DNA, Complementary; Gene Expre

1994
Expression of functional delta opioid receptors in Xenopus oocytes.
    Biochemical and biophysical research communications, 1993, Jun-30, Volume: 193, Issue:3

    Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4

1993
Independent and coordinate regulation of beta 1- and beta 2-adrenergic receptors in rat C6 glioma cells.
    Journal of receptor research, 1994, Volume: 14, Issue:5

    Topics: Animals; Astrocytes; Cell Differentiation; Cholera Toxin; Colforsin; Cyclic AMP; Down-Regulation; Gl

1994
Chronic treatment of C6 glioma cells with antidepressant drugs increases functional coupling between a G protein (Gs) and adenylyl cyclase.
    Journal of neurochemistry, 1995, Volume: 64, Issue:2

    Topics: Adenylyl Cyclases; Animals; Antidepressive Agents; Cell Membrane; Cytosol; Desipramine; Dose-Respons

1995
Regulation of beta-adrenergic receptor mRNA in rat C6 glioma cells is sensitive to the state of microtubule assembly.
    Journal of neurochemistry, 1994, Volume: 62, Issue:2

    Topics: Animals; Binding Sites; Colchicine; Cyclic AMP; Dose-Response Relationship, Drug; Down-Regulation; G

1994
Agonist and cyclic AMP-mediated regulation of beta 1-adrenergic receptor mRNA and gene transcription in rat C6 glioma cells.
    Journal of neurochemistry, 1994, Volume: 63, Issue:5

    Topics: Adrenergic beta-1 Receptor Agonists; Animals; Colforsin; Cyclic AMP; Down-Regulation; Endotoxins; Gl

1994
Receptor availability defines the extent of agonist-mediated G-protein down-regulation in neuroblastoma x glioma hybrid cells transfected to express the beta 2-adrenoceptor.
    FEBS letters, 1994, Nov-28, Volume: 355, Issue:2

    Topics: Adenylyl Cyclases; Adrenergic beta-2 Receptor Antagonists; Alprenolol; Down-Regulation; Gene Express

1994
Lysophosphatidic acid mimics serum-induced sensitization of cyclic AMP accumulation.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1993, Volume: 7, Issue:14

    Topics: Alprostadil; Animals; Astrocytoma; Blood; Colforsin; Cyclic AMP; Drug Interactions; Glioma; Humans;

1993
Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3

    Topics: Adenylyl Cyclase Inhibitors; Animals; Cyclic AMP; Enzyme Activation; Glioma; Isoproterenol; Kinetics

1993
Regulation of C6 glioma cell steroidogenesis by adenosine 3',5'-cyclic monophosphate.
    Glia, 1994, Volume: 10, Issue:1

    Topics: Adenylyl Cyclases; Aminoglutethimide; Animals; Cyclic AMP; Glioma; Humans; Isoproterenol; Mevalonic

1994
Endothelin- and ATP-induced inhibition of adenylyl cyclase activity in C6 glioma cells: role of Gi and calcium.
    Molecular pharmacology, 1993, Volume: 44, Issue:1

    Topics: Adenosine Triphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Calcimycin; C

1993
Human immunodeficiency virus coat protein gp120 inhibits the beta-adrenergic regulation of astroglial and microglial functions.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Feb-15, Volume: 90, Issue:4

    Topics: Adenylyl Cyclases; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Cerebral Cortex; Clonidin

1993
Ca2+ inhibition of beta-adrenergic receptor- and forskolin-stimulated cAMP accumulation in C6-2B rat glioma cells is independent of protein kinase C.
    Molecular pharmacology, 1993, Volume: 43, Issue:3

    Topics: Animals; Calcium; Colforsin; Cyclic AMP; Enzyme Activation; Glioma; Hydrolysis; Isoproterenol; Phosp

1993
Brefeldin A blocks the response of cultured cells to cholera toxin. Implications for intracellular trafficking in toxin action.
    The Journal of biological chemistry, 1993, Jun-05, Volume: 268, Issue:16

    Topics: Adenocarcinoma; Adenylyl Cyclases; Animals; Biological Transport; Brefeldin A; Cell Line; Chloroquin

1993
[Effects of tubulin on beta adrenergic receptor linked to adenylyl cyclase system].
    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology, 1993, Volume: 13, Issue:1

    Topics: Adenylyl Cyclases; Animals; Cell Membrane Permeability; Cells, Cultured; Glioma; GTP-Binding Protein

1993
Comparison of duration of agonist action at beta 1- and beta 2- adrenoceptors in C6 glioma cells: evidence that the long duration of action of salmeterol is specific to the beta 2-adrenoceptor.
    Molecular pharmacology, 1996, Volume: 49, Issue:5

    Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists;

1996
Expression of the extraneuronal monoamine transporter (uptake2) in human glioma cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 353, Issue:3

    Topics: 1-Methyl-4-phenylpyridinium; Amines; Anti-Inflammatory Agents; Barium; Binding, Competitive; Cortico

1996
Inducible expression of beta 1- and beta 2-adrenergic receptors in rat C6 glioma cells: functional interactions between closely related subtypes.
    Molecular pharmacology, 1996, Volume: 50, Issue:1

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Colforsin; Cyclic AMP; Epinephrine;

1996
Correlation between increased AP-1NGF binding activity and induction of nerve growth factor transcription by multiple signal transduction pathways in C6-2B glioma cells.
    Brain research. Molecular brain research, 1996, Volume: 35, Issue:1-2

    Topics: Animals; Base Sequence; Cell Line; Cell Nucleus; Enzyme Inhibitors; Fibroblast Growth Factor 2; Glio

1996
Adrenergic regulation of ICER (inducible cyclic AMP early repressor) and beta1-adrenergic receptor gene expression in C6 glioma cells.
    Journal of neurochemistry, 1996, Volume: 67, Issue:2

    Topics: Animals; Base Sequence; Binding Sites; Cyclic AMP Response Element Modulator; DNA Primers; DNA-Bindi

1996
Modulation of cyclic AMP accumulation in glial cells by exogenous phospholipase C.
    Journal of lipid mediators and cell signalling, 1996, Volume: 13, Issue:1

    Topics: Adenylate Cyclase Toxin; Astrocytoma; Colforsin; Cyclic AMP; Down-Regulation; Glioma; Humans; Isopro

1996
Agonist regulation of adenylate cyclase activity in neuroblastoma x glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the beta 2-adrenoceptor. Evidence that adenylate cyclase is the limiting component for receptor-mediat
    The Biochemical journal, 1996, Sep-15, Volume: 318 ( Pt 3)

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Amino Acid Sequence; Base Sequence; DNA Primers; DNA, C

1996
Selective desensitization of beta 1- and beta 2-andrenergic receptors in C6 glioma cells. Effects on catecholamine responsiveness.
    Receptor, 1995, Volume: 5, Issue:4

    Topics: Adrenergic beta-Agonists; Animals; Cell Membrane; Cyclic AMP; Dexamethasone; Epinephrine; Glioma; Gl

1995
Cyclic AMP inhibits activation of mitogen-activated protein kinase and cell proliferation in response to growth factors in cultured rat cortical astrocytes.
    Journal of neurochemistry, 1996, Volume: 67, Issue:6

    Topics: Adrenergic beta-Agonists; Animals; Astrocytes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Di

1996
Noradrenaline inhibits the programmed cell death induced by 1,25-dihydroxyvitamin D3 in glioma.
    European journal of pharmacology, 1997, Jan-29, Volume: 319, Issue:2-3

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Apoptosis; Brain Neoplasms; Calcitri

1997
The extraneuronal monoamine transporter exists in human central nervous system glia.
    Advances in pharmacology (San Diego, Calif.), 1998, Volume: 42

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Astrocytes; Biological Transport; Cells, Cultured; Cerebral Co

1998
Cross-talk between beta-adrenergic and metabotropic glutamate receptors in rat C6 glioma cells.
    Biochimica et biophysica acta, 1998, Jul-31, Volume: 1393, Issue:1

    Topics: Adrenergic beta-Agonists; Animals; Cell Membrane; Enzyme Activation; Glioma; Glutamic Acid; Isoenzym

1998
Interleukin-1beta and catecholamines synergistically stimulate interleukin-6 release from rat C6 glioma cells in vitro: a potential role for lysophosphatidylcholine.
    Endocrinology, 1999, Volume: 140, Issue:2

    Topics: Adrenergic beta-Agonists; Animals; Catecholamines; Cyclic AMP; Drug Synergism; Glioma; Interleukin-1

1999
The effect of hydrogen peroxide upon beta-adrenoceptor density and function in C6 rat glioma cells.
    Neurochemistry international, 1999, Volume: 34, Issue:1

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Cell Death; Colforsin; Culture Media, Serum-Fr

1999
Probing for drug-induced multiplex signal transduction pathways using high resolution two-dimensional gel electrophoresis: application to beta-adrenoceptor stimulation in the rat C6 glioma cell.
    Brain research. Molecular brain research, 1999, Jul-23, Volume: 71, Issue:1

    Topics: Animals; Brain Neoplasms; Cyclic AMP; Electrophoresis, Gel, Two-Dimensional; Glioma; Isoproterenol;

1999
Ethanol uses cAMP-independent signal transduction mechanisms to activate proenkephalin promoter activity in rat C6 glioma cells.
    Alcoholism, clinical and experimental research, 2000, Volume: 24, Issue:7

    Topics: Adrenergic beta-Agonists; Animals; Central Nervous System Depressants; Choline O-Acetyltransferase;

2000
Antioxidant defense against antidepressants in C6 and 1321N1 cells.
    Chemico-biological interactions, 2000, Jul-14, Volume: 127, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Antidepressive Agents; Antimetabolit

2000
Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma.
    Experimental cell research, 2000, Nov-25, Volume: 261, Issue:1

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Cell Differentiation; Cyclic AMP; Cyto

2000
Protein tyrosine kinase-dependent regulation of adenylate cyclase and phosphatidylinositol 3-kinase activates the expression of glial fibrillary acidic protein upon induction of differentiation in rat c6 glioma.
    Cell biology international, 2001, Volume: 25, Issue:5

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Androstadienes; Animals; Anti-Bacterial Agents; Benzoqu

2001
Agonist-mediated down-regulation of rat beta1-adrenergic receptor transcripts: role of potential post-transcriptional degradation factors.
    Molecular pharmacology, 2001, Volume: 60, Issue:6

    Topics: 3' Untranslated Regions; Adrenergic beta-Agonists; Animals; Antigens, Surface; Base Sequence; Blotti

2001
In vivo labelling of beta-adrenergic receptors on rat glioma cells.
    FEBS letters, 1977, Apr-15, Volume: 76, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Cell Line; Glioma; Isoproterenol; Kinetics; Phentolamine; Pind

1977
Regulation of nerve growth factor content in C6 glioma cells by beta-adrenergic receptor stimulation.
    Naunyn-Schmiedeberg's archives of pharmacology, 1977, Volume: 300, Issue:2

    Topics: Adrenergic beta-Antagonists; Cyclic AMP; Glioma; Isoproterenol; Nerve Growth Factors; Neuroglia; Neu

1977
Desensitization of beta receptor mediated cyclic AMP response of cultured fibroblasts by partial agonists.
    Journal of cyclic nucleotide research, 1979, Volume: 5, Issue:1

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cells, Cultured; Cyclic AMP; Fibrobl

1979
The regulation of adenosine 3':5'-cyclic monophosphate accumulation in glia by alpha-adrenergic agonists.
    Life sciences, 1979, Feb-12, Volume: 24, Issue:7

    Topics: Adrenergic alpha-Agonists; Cyclic AMP; Glioma; Humans; In Vitro Techniques; Isoproterenol; Neuroglia

1979
Quantitative relationship between beta-adrenergic receptor number and physiologic responses as studied with a long-lasting beta-adrenergic antagonist.
    Proceedings of the National Academy of Sciences of the United States of America, 1979, Volume: 76, Issue:12

    Topics: Adrenergic beta-Antagonists; Animals; Cell Line; Cyclic AMP; Glioma; Guinea Pigs; Heart Atria; In Vi

1979
Cyclic AMP, membrane transport and cell division. I. Effects of various chemicals on cyclic AMP levels and rate of transport of neucleosides, hypoxanthine and deoxyglucose in several lines of cultured cells.
    Journal of cellular physiology, 1975, Volume: 85, Issue:2 Pt 1

    Topics: Animals; Biological Transport, Active; Bucladesine; Carcinoma, Hepatocellular; Cell Division; Cell L

1975
Measurements of adenosine 3':5'-cyclic monophosphate and membrane potential in neuroblastoma times glioma hybrid cells: opiates and adrenergic agonists cause effects opposite to those of prostaglandin E1.
    FEBS letters, 1975, Apr-01, Volume: 52, Issue:2

    Topics: Animals; Cell Line; Clone Cells; Cyclic AMP; Dopamine; Glioma; Haloperidol; Hybrid Cells; Isoprotere

1975
Cyclic AMP-mediated induction of ornithine decarboxylase of glioma and neuroblastoma cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1975, Volume: 72, Issue:8

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Bucladesine; Carboxy-Lyases; Cell Line; Cyclic AMP;

1975
Drug-induced alterations in morphology and level of cAMP in cultured human glioma cells.
    Experimental cell research, 1975, Oct-15, Volume: 95, Issue:2

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Catecholamines; Cell Line; Cyclic AMP; Cycl

1975
Affinity isolation of cultured tumor cells by means of drugs and hormones covalently bound to glass and Sepharose beads.
    Proceedings of the National Academy of Sciences of the United States of America, 1976, Volume: 73, Issue:6

    Topics: Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Animals; Cell Membrane; Cell Separation; Cells

1976
Desensitization of beta-adrenergic receptors of glioma cells: studies with intact and broken cell preparations.
    FEBS letters, 1976, Jul-15, Volume: 66, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Glioma

1976
Use of (-)-[3H]dihydroalprenolol to study beta adrenergic receptor-adenylate cyclase coupling in C6 glioma cells: role of 5'-guanylylimidodiphosphate.
    Molecular pharmacology, 1977, Volume: 13, Issue:2

    Topics: Adenylyl Cyclases; Alprenolol; Binding Sites; Clone Cells; Drug Interactions; Enzyme Activation; Gli

1977
Reduction in beta-adrenergic response of cultured glioma cells following depletion of intracellular GTP.
    European journal of biochemistry, 1977, Jul-01, Volume: 77, Issue:1

    Topics: Adenosine Triphosphate; Adenylyl Cyclases; Cell Line; Cell Membrane; Cyclic AMP; Enzyme Activation;

1977
Impairment of hormone dependent signal transfer by chronic SSPE virus infection.
    The Journal of general virology, 1979, Volume: 42, Issue:3

    Topics: Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Glioma; Isoproterenol; Rats; Receptors, Adrenergi

1979
Induction of S-adenosyl-L-methionine decarboxylase in glioma and neuroblastoma cells.
    FEBS letters, 1977, Mar-15, Volume: 75, Issue:1

    Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Line; Culture Media; Enzyme Inductio

1977
Calcium fluxes in cultured and bulk isolated neuronal and glial cells.
    Journal of neurochemistry, 1977, Volume: 29, Issue:3

    Topics: Acetylcholine; Animals; Astrocytes; Brain Neoplasms; Calcium; Cells, Cultured; Choline; Glioma; Huma

1977
Glucocorticoid-mediated down regulation of c-fos mRNA in C6 glioma cells: lack of correlation with proenkephalin mRNA.
    Brain research. Molecular brain research, 1992, Volume: 12, Issue:1-3

    Topics: Animals; Base Sequence; Brain; Cell Line; Dexamethasone; Enkephalins; Gene Expression Regulation, Ne

1992
Dose-dependent down-regulation of beta-adrenoceptors by isoproterenol in rat C6 glioma cells.
    European journal of pharmacology, 1992, Feb-13, Volume: 225, Issue:2

    Topics: Animals; Cyclic AMP; Dose-Response Relationship, Drug; Down-Regulation; Glioma; Isoproterenol; Rats;

1992
Beta-adrenergic stimulation of C6 glioma cells: effects of cAMP overproduction on cellular metabolites. A multinuclear NMR study.
    European journal of biochemistry, 1992, Oct-15, Volume: 209, Issue:2

    Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; Cyclic AMP; Glioma; Glucose; Glutamates; Glutamine

1992
Altered genetic response to beta-adrenergic receptor activation in late passage C6 glioma cells.
    Journal of neuroscience research, 1992, Volume: 33, Issue:2

    Topics: Actins; Amyloid beta-Protein Precursor; Animals; Blotting, Northern; Bucladesine; Cell Division; Enk

1992
Pre-steady state study of beta-adrenergic and purinergic receptor interaction in C6 cell membranes: undelayed balance between positive and negative coupling to adenylyl cyclase.
    Molecular pharmacology, 1992, Volume: 42, Issue:6

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Cell Memb

1992
Idazoxan down-regulates beta-adrenoceptors on C6 glioma cells in vitro.
    European journal of pharmacology, 1992, Nov-02, Volume: 227, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Autoradiography; Cholera Toxin; Colforsin; Cyclic AMP; Dioxan

1992
2-Aminopurine inhibits RNA and protein synthesis and reduces catecholamine desensitization in C6-2B rat glioma cells.
    FEBS letters, 1992, Jan-13, Volume: 296, Issue:1

    Topics: 2-Aminopurine; 3T3 Cells; Animals; Bucladesine; Catecholamines; Colforsin; Cyclic AMP; Drug Interact

1992
Cyclic AMP-induced upregulation of proteolipid protein and myelin associated glycoprotein gene expression in C6 cells.
    Journal of neuroscience research, 1992, Volume: 31, Issue:3

    Topics: Animals; Blotting, Northern; Cell Nucleus; Colforsin; Cyclic AMP; Glioma; Isoproterenol; Myelin Prot

1992
Serum-induced sensitization of cyclic AMP accumulation in C62B rat glioma cells.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Physiological Phenomena; Cyclic AMP; Glioma; Isoproteren

1992
Astroglial membrane structure is affected by agents that raise cyclic AMP and by phosphatidylcholine phospholipase C.
    Journal of neurocytology, 1992, Volume: 21, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Astrocytes; Cattle; Ce

1992
The beta-adrenoceptor-coupled adenylate cyclase system in rat C6 glioma cells. Deamplification by isoproterenol and oxaprotiline.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1992, Volume: 7, Issue:2

    Topics: Adenylyl Cyclases; Animals; Antidepressive Agents; Autoradiography; Blotting, Northern; Brain Neopla

1992
Functional analysis of rabbit anti-peptide antibodies which mimic autoantibodies against the beta 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy.
    Journal of autoimmunity, 1991, Volume: 4, Issue:6

    Topics: Amino Acid Sequence; Animals; Autoantibodies; Binding Sites; Binding, Competitive; Cardiomyopathy, H

1991
Beta-adrenergic treatment of C6 glioma cells produces opposite changes in c-fos and c-jun mRNA levels.
    Journal of neuroscience research, 1991, Volume: 30, Issue:4

    Topics: Adrenergic beta-Agonists; Animals; Blotting, Northern; Dose-Response Relationship, Drug; Glioma; Iso

1991
Inhibition of cAMP accumulation by intracellular calcium mobilization in C6-2B cells stably transfected with substance K receptor cDNA.
    Proceedings of the National Academy of Sciences of the United States of America, 1991, Oct-15, Volume: 88, Issue:20

    Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Anim

1991
Evidence for cAMP and cholate extrusion in C6 rat glioma cells by a common anion efflux pump.
    The Journal of biological chemistry, 1991, Jan-25, Volume: 266, Issue:3

    Topics: Animals; Antimycin A; Biological Transport, Active; Cholic Acids; Cyclic AMP; Glioma; Isoproterenol;

1991
Differential down-regulation of beta 1- and beta 2-adrenergic receptor mRNA in C6 glioma cells.
    Biochemical and biophysical research communications, 1990, Jul-16, Volume: 170, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Betaxolol; Cell Division; Down-Regulation; Glioma; Isoproteren

1990
Reovirus type 3 binds to antagonist domains of the beta-adrenergic receptor.
    Journal of virology, 1990, Volume: 64, Issue:2

    Topics: Adrenal Gland Neoplasms; Animals; Binding, Competitive; Dihydroalprenolol; Glioma; Isoproterenol; Ki

1990
Regulation of cAMP levels by protein kinase C in C6 rat glioma cells.
    Journal of neuroscience research, 1990, Volume: 25, Issue:1

    Topics: Animals; Colforsin; Cyclic AMP; Glioma; Isoproterenol; Protein Kinase C; Rats; Receptors, Adrenergic

1990
Thrombin reverts the beta-adrenergic agonist-induced morphological response in rat glioma C6 cells.
    Experimental cell research, 1990, Volume: 189, Issue:1

    Topics: Animals; Antithrombin III; Astrocytes; Blood; Calcium; Culture Media; Epithelial Cells; Glioma; Hiru

1990
Identification and characterization of the beta-adrenergic receptor on neuroblastoma x glioma hybrid NG108-15 cells.
    Cellular and molecular neurobiology, 1990, Volume: 10, Issue:3

    Topics: Alprenolol; Bucladesine; Catecholamines; Cell Differentiation; Dihydroalprenolol; Glioma; Hybrid Cel

1990
Activation and de novo synthesis of transglutaminase in cultured glioma cells.
    Journal of cellular physiology, 1985, Volume: 124, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cells, Cultured; Cycloheximide; Dactinomycin; Fluor

1985
Rat interferon inhibits catecholamine-inducible synthesis of lactic dehydrogenase in rat glial tumoral C6 cells.
    Journal of interferon research, 1986, Volume: 6, Issue:2

    Topics: Animals; Catecholamines; Cells, Cultured; Enzyme Induction; Glioma; Interferons; Isoproterenol; L-La

1986
ADP and, indirectly, ATP are potent inhibitors of cAMP production in intact isoproterenol-stimulated C6 glioma cells.
    Biochemical and biophysical research communications, 1989, Sep-15, Volume: 163, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylate Cyclase Toxin; Animals; Cyclic AMP; Glioma;

1989
Identification of functional beta-adrenergic receptors on AC glioma cells.
    Biochemical pharmacology, 1989, Oct-01, Volume: 38, Issue:19

    Topics: Animals; Cyclic AMP; Ethanolamines; Glioma; Isoproterenol; Metoprolol; Norepinephrine; Rats; Recepto

1989
Signal transduction by membrane receptors in viable electropermeabilized cells: isoproterenol-stimulated cyclic AMP synthesis in C6 glioma cells.
    Biochimica et biophysica acta, 1989, Sep-04, Volume: 984, Issue:2

    Topics: Adenosine Triphosphate; Adrenergic beta-Antagonists; Animals; Cell Line; Cell Membrane; Cell Membran

1989
Effect of sodium butyrate on S-100 protein levels and the cAMP response.
    Journal of cellular physiology, 1987, Volume: 133, Issue:1

    Topics: Animals; Butyrates; Butyric Acid; Colforsin; Cyclic AMP; Glial Fibrillary Acidic Protein; Glioma; Hu

1987
Influence of opioids on beta-receptors down-regulation: studies in cultured C6 glioma cells.
    Brain research, 1987, Oct-13, Volume: 423, Issue:1-2

    Topics: Animals; Cell Line; Cell Membrane; Cyclic AMP; Desipramine; Glioma; Isoproterenol; Kinetics; Morphin

1987
[Treatment of rat glioma with a beta-adrenergic agonist and a phosphodiesterase inhibitor in vivo].
    No to shinkei = Brain and nerve, 1987, Volume: 39, Issue:8

    Topics: Animals; Brain Neoplasms; Cyclic AMP; Glioma; Injections, Spinal; Isoproterenol; Meningeal Neoplasms

1987
A quenched-flow study of a receptor-triggered second messenger response: cyclic AMP burst elicited by isoproterenol in C6 glioma cell membranes.
    FEBS letters, 1988, Jan-04, Volume: 226, Issue:2

    Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; Cyclic AMP; Glioma; Is

1988
Beta-adrenergic receptor regulation of NGF-mRNA content in rat C6-2B glioma cells.
    Neuropharmacology, 1987, Volume: 26, Issue:12

    Topics: Animals; Astrocytoma; Glioma; Isoproterenol; Nerve Growth Factors; Rats; Receptors, Adrenergic, beta

1987
Stimulation of nerve growth factor mRNA content in C6 glioma cells by a beta-adrenergic receptor and by cyclic AMP.
    Glia, 1988, Volume: 1, Issue:4

    Topics: Animals; Blotting, Northern; Cell Line; Colforsin; Cyclic AMP; Glioma; Isoproterenol; Molecular Weig

1988
Irreversible blockade of beta-adrenergic receptors with a bromoacetyl derivative of pindolol.
    Naunyn-Schmiedeberg's archives of pharmacology, 1985, Volume: 328, Issue:3

    Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Dihydroalprenolol; Erythrocytes; Glioma; In

1985
Phorbol esters and beta-adrenergic agonists mediate desensitization of adenylate cyclase in rat glioma C6 cells by distinct mechanisms.
    The Journal of biological chemistry, 1985, Jul-25, Volume: 260, Issue:15

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Caenorhabditis elegans Proteins; Carrier Prote

1985
Selective regulation of beta-1 and beta-2 adrenergic receptors by atypical agonists.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:3

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Celiprolol; Cells, Cultured; Glioma; Guanosine

1985
Evidence for the appearance of an uncoupled form of the beta-adrenergic receptor distinct from the internalized receptor.
    Journal of cellular biochemistry, 1986, Volume: 30, Issue:3

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cell Membrane; Cells, Cultured; Dose

1986
Exfoliation of the beta-adrenergic receptor and the regulatory components of adenylate cyclase by cultured rat glioma C6 cells.
    Biochimica et biophysica acta, 1986, May-29, Volume: 886, Issue:3

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; A

1986
Down-regulation of gonadotropin and beta-adrenergic receptors by hormones and cyclic AMP.
    Journal of cellular biochemistry, 1985, Volume: 27, Issue:3

    Topics: Animals; Bucladesine; Cell Line; Cholera Toxin; Chorionic Gonadotropin; Cyclic AMP; Glioma; Isoprote

1985
The effect of polar head group substitution on phospholipid methylation and the beta-adrenergic response in C6 glial cells.
    The Biochemical journal, 1985, Nov-01, Volume: 231, Issue:3

    Topics: Animals; Cell Line; Cell Membrane; Cyclic AMP; Glioma; Isoproterenol; Methylation; Methyltransferase

1985
Turnover of beta 1- and beta 2-adrenergic receptors after down-regulation or irreversible blockade.
    Molecular pharmacology, 1986, Volume: 30, Issue:2

    Topics: Animals; Cell Line; Cell Membrane; Cycloheximide; Glioma; Iodocyanopindolol; Isoproterenol; Kinetics

1986
Effect of the tricyclic antidepressant desipramine on beta-adrenergic receptors in cultured rat glioma C6 cells.
    Journal of neurochemistry, 1987, Volume: 49, Issue:1

    Topics: Adenylyl Cyclases; Alprenolol; Animals; Cells, Cultured; Cyclic AMP; Desipramine; Glioma; Isoprotere

1987
Transient increase in intracellular concentration of adenosine 3':5'-cyclic monophosphate results in morphological and biochemical differentiation of C6 glioma cells in culture.
    Journal of neuroscience research, 1987, Volume: 17, Issue:2

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cell Differentiation; Cell Division; Cell L

1987
Guanine nucleotide activation of adenylate cyclase in saponin permeabilized glioma cells.
    FEBS letters, 1986, Oct-27, Volume: 207, Issue:2

    Topics: Adenylyl Cyclases; Cell Line; Cell Membrane Permeability; Enzyme Activation; Glioma; Guanine Nucleot

1986
Forskolin induction of S-100 protein in glioma and hybrid cells.
    Journal of cellular physiology, 1985, Volume: 122, Issue:1

    Topics: Adenylyl Cyclases; Alprostadil; Animals; Cell Line; Colforsin; Cycloheximide; Dactinomycin; Diterpen

1985
Cyclic AMP-mediated induction of the cyclic AMP phosphodiesterase of C-6 glioma cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1974, Volume: 71, Issue:10

    Topics: Animals; Bucladesine; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Enzyme Induction; Glioma;

1974
Biologically active catecholamines covalentyly bound to glass beads.
    Proceedings of the National Academy of Sciences of the United States of America, 1972, Volume: 69, Issue:5

    Topics: Animals; Catecholamines; Cell Line; Chick Embryo; Clone Cells; Culture Techniques; Cyclic AMP; Dogs;

1972
Expression of genes for metabolism of cyclic adenosine 3':5'-monophosphate in somatic cells. I. Responses to catecholamines in parental and hybrid cells.
    The Journal of biological chemistry, 1973, Oct-10, Volume: 248, Issue:19

    Topics: Adenocarcinoma; Animals; Cell Line; Chromosomes; Clone Cells; Cyclic AMP; Electrophoresis, Starch Ge

1973
Probenecide sensitive 3'-5'-cyclic AMP secretion by isoproterenol stimulated glial cells in culture.
    FEBS letters, 1974, Apr-15, Volume: 41, Issue:1

    Topics: Animals; Cattle; Cells, Cultured; Chromatography, DEAE-Cellulose; Clone Cells; Cyclic AMP; Glioma; I

1974
Effect of catecholamines on the adenosine 3':5'-cyclic monophosphate concentrations of clonal satellite cells of neurons.
    Proceedings of the National Academy of Sciences of the United States of America, 1971, Volume: 68, Issue:9

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aminobutyrates; Animals; Astrocytoma; Car

1971