Page last updated: 2024-10-29

isoproterenol and Extrasystole, Ventricular

isoproterenol has been researched along with Extrasystole, Ventricular in 33 studies

Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.

Research Excerpts

ExcerptRelevanceReference
"To compare the arrhythmic response to isoproterenol and exercise testing in newly diagnosed arrhythmogenic right ventricular cardiomyopathy (ARVC) patients."7.88Arrhythmogenic response to isoproterenol testing vs. exercise testing in arrhythmogenic right ventricular cardiomyopathy patients. ( Cheniti, G; Cochet, H; Denis, A; Derval, N; Douard, H; Duchateau, J; Frontera, A; Haïssaguerre, M; Hocini, M; Jaïs, P; Kitamura, T; Lim, HS; Martin, C; Martin, R; Massoullie, G; Pambrun, T; Pillois, X; Sacher, F; Takigawa, M; Vlachos, K, 2018)
"Isoproterenol testing was performed with continuous infusion of isoproterenol (45 μg/min) for 3 minutes."5.40Diagnostic value of isoproterenol testing in arrhythmogenic right ventricular cardiomyopathy. ( Amraoui, S; Bordachar, P; Cochet, H; Daly, M; Denis, A; Derval, N; Haïssaguerre, M; Hocini, M; Jaïs, P; Komatsu, Y; Lim, HS; Pillois, X; Ploux, S; Ramoul, K; Ritter, P; Sacher, F; Shah, AJ; Zemmoura, A, 2014)
"To compare the arrhythmic response to isoproterenol and exercise testing in newly diagnosed arrhythmogenic right ventricular cardiomyopathy (ARVC) patients."3.88Arrhythmogenic response to isoproterenol testing vs. exercise testing in arrhythmogenic right ventricular cardiomyopathy patients. ( Cheniti, G; Cochet, H; Denis, A; Derval, N; Douard, H; Duchateau, J; Frontera, A; Haïssaguerre, M; Hocini, M; Jaïs, P; Kitamura, T; Lim, HS; Martin, C; Martin, R; Massoullie, G; Pambrun, T; Pillois, X; Sacher, F; Takigawa, M; Vlachos, K, 2018)
" During the tilt table test on isoproterenol, the patient developed ventricular fibrillation which was corrected immediately by cardioversion."3.70Significant complications can occur with ischemic heart disease and tilt table testing. ( Clarke, E; Gillette, P; Leman, RB, 1999)
"Isoproterenol was used as a surrogate for adrenergic stimulation both in vivo and in cardiomyocytes."1.62Discrete sites of frequent premature ventricular complexes cluster within the infarct border zone and coincide with high frequency of delayed afterdepolarizations under adrenergic stimulation. ( Amoni, M; Claus, P; De Buck, S; Dries, E; Ingelaere, S; Nagaraju, C; Roderick, HL; Sipido, KR; Vandenberk, B; Vermoortele, D; Willems, R, 2021)
"Paucity of a premature ventricular complex (PVC) during ablation procedures may occur and be associated with a lower success rate."1.56Stepwise approach to induce infrequent premature ventricular complex using bolus isoproterenol and epinephrine infusion. ( Aonuma, K; Ieda, M; Igarashi, M; Komatsu, Y; Nogami, A; Sekiguchi, Y; Shinoda, Y; Yamasaki, H, 2020)
"Isoproterenol testing was performed with continuous infusion of isoproterenol (45 μg/min) for 3 minutes."1.40Diagnostic value of isoproterenol testing in arrhythmogenic right ventricular cardiomyopathy. ( Amraoui, S; Bordachar, P; Cochet, H; Daly, M; Denis, A; Derval, N; Haïssaguerre, M; Hocini, M; Jaïs, P; Komatsu, Y; Lim, HS; Pillois, X; Ploux, S; Ramoul, K; Ritter, P; Sacher, F; Shah, AJ; Zemmoura, A, 2014)
"We hypothesized that VT in arrhythmogenic right ventricular dysplasia/cardiomyopathy shows a high degree of association with the PVC at baseline."1.39High prevalence of catecholamine-facilitated focal ventricular tachycardia in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy. ( Bhonsale, A; Calkins, H; James, C; Laurita, KR; Madhavan, S; Murray, B; Nazarian, S; Needleman, M; Philips, B; Tandri, H; Tichnell, C, 2013)
"Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by mutations in cardiac ryanodine receptor (RyR2) or calsequestrin (Casq2) genes."1.39Accelerated sinus rhythm prevents catecholaminergic polymorphic ventricular tachycardia in mice and in patients. ( Faggioni, M; Hwang, HS; Kannankeril, PJ; Knollmann, BC; Nederend, I; van der Werf, C; Wilde, AA, 2013)
"Multiform premature ventricular complexes initiated the episodes of VF."1.38Characteristics of J wave-associated idiopathic ventricular fibrillation: role of drugs. ( Aizawa, Y; Chinushi, M; Furushima, H; Hasegawa, K; Iijima, K; Izumi, D; Sato, A, 2012)
"We describe a 71-year-old man with a ventricular tachycardia (VT) originating from the mitral annulus."1.33Idiopathic ventricular tachycardia originating from the posteroseptal mitral annulus: a case report. ( Ashikaga, K; Tashiro, H; Tsuchiya, T; Yamamoto, K, 2006)
"Recurrent ventricular fibrillation was initiated by short-coupled isolated monomorphic ventricular premature beats probably originating from the right ventricular outflow tract, associated with a manifest electrocardiographic pattern of Brugada syndrome."1.32Electrical storm in Brugada syndrome successfully treated using isoprenaline. ( Boveda, S; Brugada, J; Couderc, P; Delay, M; Maury, P, 2004)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (6.06)18.2507
2000's12 (36.36)29.6817
2010's14 (42.42)24.3611
2020's5 (15.15)2.80

Authors

AuthorsStudies
Aras, K1
Gams, A1
Faye, NR1
Brennan, J1
Goldrick, K1
Li, J1
Zhong, Y1
Chiang, CH1
Smith, EH1
Poston, MD1
Chivers, J1
Hanna, P1
Mori, S1
Ajijola, OA1
Shivkumar, K1
Hoover, DB1
Viventi, J1
Rogers, JA1
Bernus, O1
Efimov, IR1
Charafeddine, F1
Refaat, MM1
Shinoda, Y1
Komatsu, Y2
Nogami, A2
Igarashi, M1
Yamasaki, H1
Sekiguchi, Y1
Aonuma, K1
Ieda, M2
Hasebe, H1
Yoshida, K1
Furuyashiki, Y1
Amoni, M1
Claus, P1
Dries, E1
Nagaraju, C1
De Buck, S1
Vandenberk, B1
Ingelaere, S1
Vermoortele, D1
Roderick, HL1
Sipido, KR1
Willems, R1
Li, G1
Wang, J1
Liao, P1
Bartels, P1
Zhang, H1
Yu, D1
Liang, MC1
Poh, KK1
Yu, CY1
Jiang, F1
Yong, TF1
Wong, YP1
Hu, Z1
Huang, H1
Zhang, G1
Galupo, MJ1
Bian, JS1
Ponniah, S1
Trasti, SL1
See, K1
Foo, R1
Hoppe, UC1
Herzig, S1
Soong, TW1
Badertscher, P1
Kuehne, M1
Schaer, B1
Sticherling, C1
Osswald, S1
Reichlin, T1
Denis, A2
Sacher, F2
Derval, N2
Martin, R1
Lim, HS2
Pambrun, T1
Massoullie, G1
Duchateau, J1
Cochet, H2
Pillois, X2
Cheniti, G1
Frontera, A1
Takigawa, M1
Vlachos, K1
Martin, C1
Kitamura, T1
Hocini, M2
Douard, H1
Jaïs, P2
Haïssaguerre, M2
Wang, Y1
Patel, D1
Wang, DW2
Yan, JT1
Hsia, HH1
Liu, H1
Zhao, CX1
Zuo, HJ1
Shah, AJ1
Daly, M1
Ramoul, K1
Zemmoura, A1
Amraoui, S1
Ritter, P1
Ploux, S1
Bordachar, P1
Huang, X1
Kim, TY1
Koren, G1
Choi, BR1
Qu, Z1
Rivas, N1
Dhruvakumar, S1
Mainigi, SK1
Smith, T1
Gerstenfeld, EP1
Marchlinski, FE1
Jastrzebski, M1
Yamada, T1
Plumb, VJ1
Osorio, J1
McElderry, HT1
Doppalapudi, H1
Kay, GN1
Chinushi, M2
Hasegawa, K1
Iijima, K2
Furushima, H2
Izumi, D1
Sato, A2
Aizawa, Y1
Jia, L1
Yue-Chun, L1
Kang-Ting, J1
Na-Dan, Z1
Jia-Xuan, L1
Wen-Wu, Z1
Peng-Lin, Y1
Ji-Fei, T1
Jia-Feng, L1
Díaz Infante, E1
Cózar León, R1
Borrego, I1
Maldonado, J1
Nieto, P1
Cruz Fernández, JM1
Ashikaga, K1
Tsuchiya, T1
Tashiro, H1
Yamamoto, K1
Petric, S1
Clasen, L1
van Wessel, C1
Geduldig, N1
Ding, Z1
Schullenberg, M1
Mersmann, J1
Zacharowski, K1
Aller, MI1
Schmidt, KG1
Donner, BC1
Philips, B1
Madhavan, S1
James, C1
Tichnell, C1
Murray, B1
Needleman, M1
Bhonsale, A1
Nazarian, S1
Laurita, KR2
Calkins, H1
Tandri, H1
Faggioni, M1
Hwang, HS1
van der Werf, C1
Nederend, I1
Kannankeril, PJ2
Wilde, AA1
Knollmann, BC2
Obreztchikova, MN1
Sosunov, EA1
Anyukhovsky, EP1
Moïse, NS1
Robinson, RB1
Rosen, MR1
Miller, D1
Li, P1
Armstrong, WF1
Maury, P1
Couderc, P1
Delay, M1
Boveda, S1
Brugada, J1
Katra, RP1
Nam, GB1
Burashnikov, A1
Antzelevitch, C1
Chopra, N1
Yang, T1
Hlaing, T1
Holinstat, I1
Ettensohn, K1
Pfeifer, K1
Akin, B1
Jones, LR1
Franzini-Armstrong, C1
Shannon, TR1
Li, H1
Easley, A1
Windle, J1
Leman, RB1
Clarke, E1
Gillette, P1
Liu, YB1
Chen, WJ1
Lee, YT1
Kobayashi, Y1
Yazawa, T1
Adachi, T1
Kawamura, M1
Ryu, S1
Asano, T1
Obara, C1
Katagiri, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Multi-center, Controlled Trial to Compare the Feasibility, Safety and Efficacy of Zero-fluoroscopic Approach With Fluoroscopic Approach for the Ablation of Paroxysmal Supraventricular Tachycardia[NCT03042078]3,060 participants (Actual)Interventional2012-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for isoproterenol and Extrasystole, Ventricular

ArticleYear
Oral caffeine intake amplifies the effect of isoproterenol in patients with frequent premature ventricular contractions.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2020, 08-01, Volume: 22, Issue:8

    Topics: Adult; Aged; Caffeine; Catheter Ablation; Humans; Isoproterenol; Male; Middle Aged; Ventricular Prem

2020

Other Studies

32 other studies available for isoproterenol and Extrasystole, Ventricular

ArticleYear
Electrophysiology and Arrhythmogenesis in the Human Right Ventricular Outflow Tract.
    Circulation. Arrhythmia and electrophysiology, 2022, Volume: 15, Issue:3

    Topics: Acetylcholine; Adrenergic Agents; Cardiac Electrophysiology; Cholinergic Agents; Electrocardiography

2022
Approach to induce infrequent premature ventricular complexes.
    Pacing and clinical electrophysiology : PACE, 2020, Volume: 43, Issue:5

    Topics: Epinephrine; Humans; Isoproterenol; Ventricular Premature Complexes

2020
Stepwise approach to induce infrequent premature ventricular complex using bolus isoproterenol and epinephrine infusion.
    Pacing and clinical electrophysiology : PACE, 2020, Volume: 43, Issue:5

    Topics: Catheter Ablation; Coronary Angiography; Echocardiography; Electrocardiography; Epinephrine; Female;

2020
Discrete sites of frequent premature ventricular complexes cluster within the infarct border zone and coincide with high frequency of delayed afterdepolarizations under adrenergic stimulation.
    Heart rhythm, 2021, Volume: 18, Issue:11

    Topics: Animals; Disease Models, Animal; Epicardial Mapping; Isoproterenol; Magnetic Resonance Imaging, Cine

2021
Exclusion of alternative exon 33 of Ca
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 05-23, Volume: 114, Issue:21

    Topics: Action Potentials; Alternative Splicing; Animals; Calcium Channel Blockers; Calcium Channels, L-Type

2017
Case report: electrical storm during induced hypothermia in a patient with early repolarization.
    BMC cardiovascular disorders, 2017, Nov-15, Volume: 17, Issue:1

    Topics: Adrenergic beta-Agonists; Adult; Electrocardiography; Heart Arrest; Humans; Hypothermia, Induced; Is

2017
Arrhythmogenic response to isoproterenol testing vs. exercise testing in arrhythmogenic right ventricular cardiomyopathy patients.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2018, 06-01, Volume: 20, Issue:FI1

    Topics: Action Potentials; Adrenergic beta-Agonists; Adult; Arrhythmogenic Right Ventricular Dysplasia; Case

2018
β1-Adrenoceptor blocker aggravated ventricular arrhythmia.
    Pacing and clinical electrophysiology : PACE, 2013, Volume: 36, Issue:11

    Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Agonists; Adult; Aminophylline; Female; Huma

2013
Diagnostic value of isoproterenol testing in arrhythmogenic right ventricular cardiomyopathy.
    Circulation. Arrhythmia and electrophysiology, 2014, Volume: 7, Issue:4

    Topics: Adrenergic beta-Agonists; Adult; Arrhythmogenic Right Ventricular Dysplasia; Early Diagnosis; Electr

2014
Spontaneous initiation of premature ventricular complexes and arrhythmias in type 2 long QT syndrome.
    American journal of physiology. Heart and circulatory physiology, 2016, 12-01, Volume: 311, Issue:6

    Topics: Adrenergic beta-Agonists; Animals; Animals, Genetically Modified; Arrhythmias, Cardiac; Calcium; Com

2016
Ventricular premature depolarizations triggered by incremental dose isoproterenol infusion: common electrocardiographic features.
    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2009, Volume: 25, Issue:1

    Topics: Adult; Cardiotonic Agents; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Is

2009
Double fire or junctional ectopy?
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2009, Volume: 11, Issue:8

    Topics: Cardiotonic Agents; Diagnosis, Differential; Electrocardiography; Humans; Isoproterenol; Tachycardia

2009
A regular narrow QRS complex tachycardia with alternating atrial activation sequences within the coronary sinus: what is the mechanism?
    Pacing and clinical electrophysiology : PACE, 2010, Volume: 33, Issue:10

    Topics: Adenosine; Adult; Catheter Ablation; Female; Humans; Isoproterenol; Tachycardia, Supraventricular; V

2010
Characteristics of J wave-associated idiopathic ventricular fibrillation: role of drugs.
    Pacing and clinical electrophysiology : PACE, 2012, Volume: 35, Issue:8

    Topics: Anti-Arrhythmia Agents; Cardiotonic Agents; Defibrillators, Implantable; Humans; Isoproterenol; Male

2012
Premature ventricular contractions originating from the left ventricular septum: results of radiofrequency catheter ablation in twenty patients.
    BMC cardiovascular disorders, 2011, Jun-02, Volume: 11

    Topics: Action Potentials; Adolescent; Adrenergic beta-Agonists; Adult; Aged; Body Surface Potential Mapping

2011
[Ablation of premature ventricular contractions originating in the right ventricular outflow tract using non-contact mapping].
    Revista espanola de cardiologia, 2011, Volume: 64, Issue:12

    Topics: Adrenergic beta-Agonists; Adult; Anti-Arrhythmia Agents; Catheter Ablation; Electrocardiography; Ele

2011
Idiopathic ventricular tachycardia originating from the posteroseptal mitral annulus: a case report.
    Journal of cardiovascular electrophysiology, 2006, Volume: 17, Issue:12

    Topics: Adenosine Triphosphate; Aged; Cardiotonic Agents; Catheter Ablation; Cyclic AMP; Exercise; Humans; I

2006
In vivo electrophysiological characterization of TASK-1 deficient mice.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2012, Volume: 30, Issue:3

    Topics: Adrenergic beta-Agonists; Anesthetics; Animals; Atrial Function; Baroreflex; Electric Stimulation; E

2012
High prevalence of catecholamine-facilitated focal ventricular tachycardia in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy.
    Circulation. Arrhythmia and electrophysiology, 2013, Volume: 6, Issue:1

    Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Arrhythmogenic Right Ventricular Dysplasia; Balti

2013
Accelerated sinus rhythm prevents catecholaminergic polymorphic ventricular tachycardia in mice and in patients.
    Circulation research, 2013, Feb-15, Volume: 112, Issue:4

    Topics: Adult; Animals; Atropine; Bradycardia; Caffeine; Calcium Signaling; Calsequestrin; Cardiac Pacing, A

2013
Short-coupling premature ventricular complexes from the left ventricle triggered isoproterenol-resistant electrical storm in a patient with Brugada syndrome.
    Heart rhythm, 2013, Volume: 10, Issue:6

    Topics: Adult; Anti-Arrhythmia Agents; Bepridil; Brugada Syndrome; Cardiotonic Agents; Electrocardiography;

2013
Heterogeneous ventricular repolarization provides a substrate for arrhythmias in a German shepherd model of spontaneous arrhythmic death.
    Circulation, 2003, Sep-16, Volume: 108, Issue:11

    Topics: Action Potentials; Animals; Cells, Cultured; Death, Sudden, Cardiac; Dogs; Electric Conductivity; He

2003
The effect of time and of vasoactive drugs on capillary leakage induced during myocardial contrast echocardiography.
    Echocardiography (Mount Kisco, N.Y.), 2004, Volume: 21, Issue:2

    Topics: Animals; Bronchodilator Agents; Capillary Fragility; Coloring Agents; Contrast Media; Echocardiograp

2004
Electrical storm in Brugada syndrome successfully treated using isoprenaline.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2004, Volume: 6, Issue:2

    Topics: Adrenergic beta-Agonists; Adult; Bundle-Branch Block; Defibrillators, Implantable; Electrocardiograp

2004
Cellular mechanism of calcium-mediated triggered activity in the heart.
    Circulation research, 2005, Mar-18, Volume: 96, Issue:5

    Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Calcium; Calcium Channels; Calcium Signaling;

2005
Cellular mechanisms underlying the development of catecholaminergic ventricular tachycardia.
    Circulation, 2005, May-31, Volume: 111, Issue:21

    Topics: Action Potentials; Animals; Caffeine; Calcium; Catecholamines; Disease Models, Animal; Dogs; Dose-Re

2005
Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice.
    Circulation research, 2007, Sep-14, Volume: 101, Issue:6

    Topics: Animals; Calbindin 2; Calcium; Calcium Channels; Calcium Signaling; Calsequestrin; Cardiac Pacing, A

2007
Linking calsequestrin to lumenal control of SR Ca2+ release.
    Circulation research, 2007, Sep-14, Volume: 101, Issue:6

    Topics: Animals; Calbindin 2; Calcium; Calcium Channels; Calcium Signaling; Calsequestrin; Cardiac Pacing, A

2007
Problematic palpitations and exercise induced preexcitation.
    Pacing and clinical electrophysiology : PACE, 1997, Volume: 20, Issue:1 Pt 1

    Topics: Adenosine; Adult; Anti-Arrhythmia Agents; Bundle of His; Cardiac Pacing, Artificial; Cardiotonic Age

1997
Significant complications can occur with ischemic heart disease and tilt table testing.
    Pacing and clinical electrophysiology : PACE, 1999, Volume: 22, Issue:4 Pt 1

    Topics: Adrenergic beta-Agonists; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Bundle-Branch Blo

1999
Apparent ventricular bigeminy in the congenital long QT syndrome: what is the mechanism?
    Journal of cardiovascular electrophysiology, 2000, Volume: 11, Issue:3

    Topics: Action Potentials; Adrenergic beta-Agonists; Adult; Diagnosis, Differential; Electrocardiography; Fe

2000
Ventricular arrhythmias with left bundle branch block pattern and inferior axis: assessment of their mechanisms on the basis of response to ATP, nicorandil and verapamil.
    Japanese circulation journal, 2000, Volume: 64, Issue:11

    Topics: Adenosine Triphosphate; Adult; Anti-Arrhythmia Agents; Biological Transport, Active; Bundle-Branch B

2000