isoproterenol has been researched along with Endotoxemia in 9 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Endotoxemia was induced in rats by intravenous injection of lipopolysaccharide (LPS)." | 1.42 | Increased β2-adrenergic vasorelaxation at the early phase of endotoxemic shock in rats. ( André, G; Blanloeil, Y; Ferron, M; Gauthier, C; Lauzier, B; Loirand, G; Merlet, N; Roul, D; Rozec, B; Sauzeau, V; Tran Quang, T, 2015) |
| "Gram negative endotoxemia is associated with an intrinsic impairment of cardiomyocyte contraction, in part due to a reduction in myofilament Ca2+ responsiveness." | 1.33 | Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I. ( Cave, AC; Grieve, DJ; Kentish, JC; Layland, J; Shah, AM; Solaro, RJ; Sparks, E; Warren, C, 2005) |
| "Pretreatment with isoproterenol (10 mg/kg) blunted the LPS-induced TNF response, increased the LPS-induced formation of interleukin-10 and interleukin-6 and reduced the LPS-induced production of NO in conscious mice." | 1.30 | Isoproterenol regulates tumour necrosis factor, interleukin-10, interleukin-6 and nitric oxide production and protects against the development of vascular hyporeactivity in endotoxaemia. ( Haskó, G; Kvetan, V; Németh, ZH; Pastores, SM; Salzman, AL; Szabó, C; Vizi, ES; Zingarelli, B, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schwarzl, M | 1 |
| Seiler, S | 1 |
| Wallner, M | 1 |
| von Lewinski, D | 1 |
| Huber, S | 1 |
| Maechler, H | 1 |
| Steendijk, P | 1 |
| Zelzer, S | 1 |
| Truschnig-Wilders, M | 1 |
| Obermayer-Pietsch, B | 1 |
| Lueger, A | 1 |
| Pieske, BM | 1 |
| Post, H | 1 |
| Roul, D | 1 |
| Rozec, B | 1 |
| André, G | 1 |
| Merlet, N | 1 |
| Tran Quang, T | 1 |
| Lauzier, B | 1 |
| Ferron, M | 1 |
| Blanloeil, Y | 1 |
| Loirand, G | 1 |
| Sauzeau, V | 1 |
| Gauthier, C | 1 |
| Layland, J | 1 |
| Cave, AC | 1 |
| Warren, C | 1 |
| Grieve, DJ | 1 |
| Sparks, E | 1 |
| Kentish, JC | 1 |
| Solaro, RJ | 1 |
| Shah, AM | 2 |
| Suberville, S | 1 |
| Bellocq, A | 1 |
| Fouqueray, B | 1 |
| Philippe, C | 1 |
| Lantz, O | 1 |
| Perez, J | 1 |
| Baud, L | 1 |
| Szabó, C | 1 |
| Haskó, G | 1 |
| Zingarelli, B | 1 |
| Németh, ZH | 1 |
| Salzman, AL | 1 |
| Kvetan, V | 1 |
| Pastores, SM | 1 |
| Vizi, ES | 2 |
| Abi-Gerges, N | 1 |
| Tavernier, B | 2 |
| Mebazaa, A | 2 |
| Faivre, V | 1 |
| Paqueron, X | 1 |
| Payen, D | 1 |
| Fischmeister, R | 1 |
| Méry, PF | 1 |
| Constable, PD | 1 |
| Szelényi, J | 1 |
| Kiss, JP | 1 |
| Puskás, E | 1 |
| Selmeczy, Z | 1 |
| Szelényi, M | 1 |
| Li, JM | 1 |
| El-Omar, MM | 1 |
| Lanone, S | 1 |
| Yang, ZK | 1 |
| Trayer, IP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Energy MEtabolism of Septic Heart.[NCT05202938] | 32 participants (Anticipated) | Observational | 2022-07-21 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for isoproterenol and Endotoxemia
| Article | Year |
|---|---|
Mild hypothermia attenuates circulatory and pulmonary dysfunction during experimental endotoxemia.
Topics: Animals; Cardiac Output; Cardiotonic Agents; Cytokines; Endotoxemia; Heart Rate; Heart Ventricles; H | 2013 |
Increased β2-adrenergic vasorelaxation at the early phase of endotoxemic shock in rats.
Topics: Adrenergic beta-Agonists; Animals; Endothelium, Vascular; Endotoxemia; Isoproterenol; Lipopolysaccha | 2015 |
Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I.
Topics: Actin Cytoskeleton; Animals; Calcium; Cyclic AMP-Dependent Protein Kinases; Diastole; Endotoxemia; I | 2005 |
Regulation of interleukin-10 production by beta-adrenergic agonists.
Topics: Adjuvants, Immunologic; Adrenergic beta-Agonists; Animals; Down-Regulation; Endotoxemia; Interleukin | 1996 |
Isoproterenol regulates tumour necrosis factor, interleukin-10, interleukin-6 and nitric oxide production and protects against the development of vascular hyporeactivity in endotoxaemia.
Topics: Adrenergic beta-Agonists; Animals; Cytokines; Endotoxemia; Interleukin-10; Interleukin-6; Isoprotere | 1997 |
Sequential changes in autonomic regulation of cardiac myocytes after in vivo endotoxin injection in rat.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl | 1999 |
Acute endotoxemia increases left ventricular contractility and diastolic stiffness in calves.
Topics: Anesthetics, Intravenous; Animals; Animals, Newborn; Blood Pressure; Cardiac Output; Cardiotonic Age | 1999 |
Opposite role of alpha2- and beta-adrenoceptors in the modulation of interleukin-10 production in endotoxaemic mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Endotoxemia; Enzyme-Linked Immunos | 2000 |
Cardiac contractile impairment associated with increased phosphorylation of troponin I in endotoxemic rats.
Topics: Actin Cytoskeleton; Animals; Calcium; Cytosol; Endotoxemia; Heart; Heart Ventricles; Homeostasis; Hy | 2001 |