Page last updated: 2024-10-29

isoproterenol and Down Syndrome

isoproterenol has been researched along with Down Syndrome in 8 studies

Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.

Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)

Research Excerpts

ExcerptRelevanceReference
"Murine trisomy 16 (Ts16) has been proposed as a model to study Down's syndrome (DS), because mouse chromosome 16 carries several genes homologous to loci on the human chromosome 21."1.27Adrenergic sensitivity of cultured murine trisomy 16 cells. ( Ozand, PT; Reed, WD, 1985)
"Down syndrome (DS; trisomy 21) cells had an approximately 10-fold greater response to beta-adrenergic agonists than did either normal diploid skin fibroblasts or other aneusomic fibroblast strains (trisomy 13, 18, and 22)."1.26Down syndrome fibroblasts are hyperresponsive to beta-adrenergic stimulation. ( Hanson, DR; Heston, LL; Lubiniecki, A; McSwigan, JD; Sheppard, JR, 1981)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19903 (37.50)18.7374
1990's2 (25.00)18.2507
2000's1 (12.50)29.6817
2010's1 (12.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Roque, AL1
Johnson, MW1
Stasko, MR1
de Abreu, LC1
da Silva, TD1
Costa, ACS1
Baamonde, C3
Martínez-Cué, C2
Flórez, J3
Dierssen, M3
Zung, A1
Yaron, A1
Altman, Y1
Zadik, Z1
McSwigan, JD2
Hanson, DR1
Lubiniecki, A1
Heston, LL1
Sheppard, JR2
Wehner, JM1
White, JG1
Shows, TB1
Jakobs, KH1
Schultz, G1
Vallina, IF2
Lumbreras, MA2
Calatayud, SG1
García-Calatayud, S1
Reed, WD1
Ozand, PT1

Other Studies

8 other studies available for isoproterenol and Down Syndrome

ArticleYear
Noninvasive assessment of autonomic modulation of heart rate variability in the Ts65Dn mouse model of Down syndrome: A proof of principle study.
    Physiological reports, 2020, Volume: 8, Issue:12

    Topics: Adrenergic beta-Agonists; Animals; Autonomic Nervous System; Carbachol; Cholinergic Agonists; Diseas

2020
G-protein-associated signal transduction processes are restored after postweaning environmental enrichment in Ts65Dn, a Down syndrome mouse model.
    Developmental neuroscience, 2011, Volume: 33, Issue:5

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic alpha-Agonists; Adrenergic be

2011
Beta-adrenergic hyperresponsiveness in compensated hypothyroidism associated with Down syndrome.
    Pediatric research, 2005, Volume: 58, Issue:1

    Topics: Adenylyl Cyclases; Adolescent; Adult; Alprostadil; Child; Child, Preschool; Cholera Toxin; Colforsin

2005
Down syndrome fibroblasts are hyperresponsive to beta-adrenergic stimulation.
    Proceedings of the National Academy of Sciences of the United States of America, 1981, Volume: 78, Issue:12

    Topics: Adenylyl Cyclases; Cholera Toxin; Chromosomes, Human, 21-22 and Y; Cyclic AMP; Down Syndrome; Enzyme

1981
The adrenergic responsiveness of Down syndrome cells.
    Progress in clinical and biological research, 1982, Volume: 97

    Topics: Cells, Cultured; Cholera Toxin; Chromosomes, Human, 21-22 and Y; Cyclic AMP; Dose-Response Relations

1982
Impaired cyclic AMP production in the hippocampus of a Down syndrome murine model.
    Brain research. Developmental brain research, 1996, Aug-20, Volume: 95, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Colforsin; Cyclic AMP; Down Syndrome

1996
Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome.
    Brain research, 1997, Feb-28, Volume: 749, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Brain; Cell Membrane; Cerebellum; Ce

1997
Adrenergic sensitivity of cultured murine trisomy 16 cells.
    Developmental pharmacology and therapeutics, 1985, Volume: 8, Issue:3

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Alprostadil; Animals; Cell Line; Cells, Cultured; Disea

1985