isoproterenol has been researched along with Down Syndrome in 8 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
Excerpt | Relevance | Reference |
---|---|---|
"Murine trisomy 16 (Ts16) has been proposed as a model to study Down's syndrome (DS), because mouse chromosome 16 carries several genes homologous to loci on the human chromosome 21." | 1.27 | Adrenergic sensitivity of cultured murine trisomy 16 cells. ( Ozand, PT; Reed, WD, 1985) |
"Down syndrome (DS; trisomy 21) cells had an approximately 10-fold greater response to beta-adrenergic agonists than did either normal diploid skin fibroblasts or other aneusomic fibroblast strains (trisomy 13, 18, and 22)." | 1.26 | Down syndrome fibroblasts are hyperresponsive to beta-adrenergic stimulation. ( Hanson, DR; Heston, LL; Lubiniecki, A; McSwigan, JD; Sheppard, JR, 1981) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (37.50) | 18.7374 |
1990's | 2 (25.00) | 18.2507 |
2000's | 1 (12.50) | 29.6817 |
2010's | 1 (12.50) | 24.3611 |
2020's | 1 (12.50) | 2.80 |
Authors | Studies |
---|---|
Roque, AL | 1 |
Johnson, MW | 1 |
Stasko, MR | 1 |
de Abreu, LC | 1 |
da Silva, TD | 1 |
Costa, ACS | 1 |
Baamonde, C | 3 |
Martínez-Cué, C | 2 |
Flórez, J | 3 |
Dierssen, M | 3 |
Zung, A | 1 |
Yaron, A | 1 |
Altman, Y | 1 |
Zadik, Z | 1 |
McSwigan, JD | 2 |
Hanson, DR | 1 |
Lubiniecki, A | 1 |
Heston, LL | 1 |
Sheppard, JR | 2 |
Wehner, JM | 1 |
White, JG | 1 |
Shows, TB | 1 |
Jakobs, KH | 1 |
Schultz, G | 1 |
Vallina, IF | 2 |
Lumbreras, MA | 2 |
Calatayud, SG | 1 |
García-Calatayud, S | 1 |
Reed, WD | 1 |
Ozand, PT | 1 |
8 other studies available for isoproterenol and Down Syndrome
Article | Year |
---|---|
Noninvasive assessment of autonomic modulation of heart rate variability in the Ts65Dn mouse model of Down syndrome: A proof of principle study.
Topics: Adrenergic beta-Agonists; Animals; Autonomic Nervous System; Carbachol; Cholinergic Agonists; Diseas | 2020 |
G-protein-associated signal transduction processes are restored after postweaning environmental enrichment in Ts65Dn, a Down syndrome mouse model.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic alpha-Agonists; Adrenergic be | 2011 |
Beta-adrenergic hyperresponsiveness in compensated hypothyroidism associated with Down syndrome.
Topics: Adenylyl Cyclases; Adolescent; Adult; Alprostadil; Child; Child, Preschool; Cholera Toxin; Colforsin | 2005 |
Down syndrome fibroblasts are hyperresponsive to beta-adrenergic stimulation.
Topics: Adenylyl Cyclases; Cholera Toxin; Chromosomes, Human, 21-22 and Y; Cyclic AMP; Down Syndrome; Enzyme | 1981 |
The adrenergic responsiveness of Down syndrome cells.
Topics: Cells, Cultured; Cholera Toxin; Chromosomes, Human, 21-22 and Y; Cyclic AMP; Dose-Response Relations | 1982 |
Impaired cyclic AMP production in the hippocampus of a Down syndrome murine model.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Colforsin; Cyclic AMP; Down Syndrome | 1996 |
Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Brain; Cell Membrane; Cerebellum; Ce | 1997 |
Adrenergic sensitivity of cultured murine trisomy 16 cells.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Alprostadil; Animals; Cell Line; Cells, Cultured; Disea | 1985 |