isoproterenol has been researched along with Disease Models, Animal in 857 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, researchers recently investigated the potential cardioprotective effects of taraxerol utilizing an isoproterenol (ISO)-induced cardiotoxicity model among Sprague Dawley rats." | 8.31 | Effects of Taraxerol on Oxidative and Inflammatory Mediators in Isoproterenol-Induced Cardiotoxicity in an Animal Model. ( Alam, A; Alkholifi, FK; Aodah, AH; Devi, S; Foudah, AI; Yusufoglu, HS, 2023) |
| "Inflammation can contribute to the initiation and progression of atrial fibrillation (AF), and pinocembrin can suppress downstream inflammatory cytokine production by inhibiting the inflammation pathway." | 8.12 | Pinocembrin alleviates the susceptibility to atrial fibrillation in isoproterenol-induced rats. ( Chen, X; Liu, Z; Wan, W; Yang, B; Ye, T; Yu, Y; Zhang, C, 2022) |
| " This study investigated the therapeutic benefit of adding rosuvastatin to low-dose carvedilol in protection against myocardial infarction (MI)." | 8.02 | Rosuvastatin and low-dose carvedilol combination protects against isoprenaline-induced myocardial infarction in rats: Role of PI3K/Akt/Nrf2/HO-1 signalling. ( Awad, AS; Baraka, SA; El-Demerdash, E; El-Naga, RN; Elsherbini, DA; Tolba, MF, 2021) |
| " The study aims to understand the effect of arbutin on isoproterenol (ISO)-induced cardiac hypertrophy in mice." | 7.96 | Arbutin Attenuates Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting TLR-4/NF-κB Pathway in Mice. ( Alavala, S; Jerald, MK; Mir, SM; Nalban, N; Sangaraju, R; Sistla, R, 2020) |
| "This study aimed to investigate the anti-fibrotic effects of ghrelin in isoproterenol (ISO)-induced myocardial fibrosis and the underlying mechanism." | 7.96 | Chronic peripheral ghrelin injection exerts antifibrotic effects by increasing growth differentiation factor 15 in rat hearts with myocardial fibrosis induced by isoproterenol. ( Feng, L; Lin, P; Ren, Q; Wang, Q; Zhang, B, 2020) |
| "Our study is aimed at evaluating the effects of pretreatment with Poly(lactic-co-glycolic) acid nanoparticle loaded with resveratrol (RSV PLGA NPs) compared to conventional resveratrol (RSV) on isoproterenol (ISO) induced myocardial infarction (MI) in rats." | 7.96 | Protective role of poly(lactic-co-glycolic) acid nanoparticle loaded with resveratrol against isoproterenol-induced myocardial infarction. ( Hu, Y; Kumar, P; Mishra, A; Moktan, JB; Sreeharsha, N; Sun, L; Wang, L, 2020) |
| " This study aimed to evaluate protective effect of ergosterol (ER) on isoproterenol (ISO)-induced myocardial cardiotoxicity." | 7.96 | Ergosterol Attenuates Isoproterenol-Induced Myocardial Cardiotoxicity. ( Dai, C; Gao, Y; Jin, L; Li, S; Song, J; Xie, Q, 2020) |
| "This research was aimed to explore protective effects of allicin on rat model of myocardial infarction via JNK signaling pathway." | 7.96 | Protective Effects of Allicin on ISO-Induced Rat Model of Myocardial Infarction via JNK Signaling Pathway. ( Li, EZ; Li, XP; Liu, YF; Ma, L; Wei, LN; Xu, W; Zhao, J, 2020) |
| " In particular, compound 4i was found to be the most potent ACE inhibitor and was further studied for cardioprotective effects against isoproterenol (ISO)-induced myocardial infarction (MI) in rats." | 7.96 | Novel thiazole-pyrazolone hybrids as potent ACE inhibitors and their cardioprotective effect on isoproterenol-induced myocardial infarction. ( Su, G; Su, X; You, H, 2020) |
| "Puerarin has shown unique pharmacological effects on myocardial ischemia (MI)." | 7.96 | The cardioprotective effects of the new crystal form of puerarin in isoproterenol-induced myocardial ischemia rats based on metabolomics. ( Du, G; Gao, Z; Li, M; Lv, Y; Qin, X; Shi, Y; Song, J; Zhou, Y, 2020) |
| " This study evaluated whether LCZ696 affects left ventricular hypertrophy, fibrosis, and hemodynamics in isoproterenol (ISO)-treated rats compared with valsartan alone." | 7.91 | Effect of LCZ696, a dual angiotensin receptor neprilysin inhibitor, on isoproterenol-induced cardiac hypertrophy, fibrosis, and hemodynamic change in rats. ( Akagi, S; Ito, H; Kondo, M; Miura, D; Miyoshi, T; Nakamura, K; Ohno, Y; Saito, Y; Yoshida, M, 2019) |
| " The investigation was conducted to evaluate the cardioprotective efficacy of RPG in rats having acute myocardial infarction (MI) induced by isoproterenol (ISO)." | 7.91 | Cardioprotective Effect of Rhapontigenin in Isoproterenol-Induced Myocardial Infarction in a Rat Model. ( Fan, Y, 2019) |
| " To assess the effects of phosphodiesterase type 3 and phosphodiesterase type 5 inhibitors on cardiac function and left ventricular myocardial fibrosis in catecholamine-induced myocardial injury, sildenafil and pimobendan were administered to male Wistar rats 24 hours after isoproterenol injection." | 7.91 | Contrasting Effects of Inhibition of Phosphodiesterase 3 and 5 on Cardiac Function and Interstitial Fibrosis in Rats With Isoproterenol-Induced Cardiac Dysfunction. ( Nakata, TM; Shimada, K; Suzuki, K; Tanaka, R; Uemura, A, 2019) |
| "To investigate the effect of acupuncture at PC6 on cardiac hypertrophy in isoproterenol (ISO)-treated mice." | 7.91 | Acupuncture at PC6 prevents cardiac hypertrophy in isoproterenol-treated mice. ( Du, Q; Guo, Y; Hou, Y; Yang, F; Zhang, M; Zhu, P, 2019) |
| "The present study aimed to investigate the potential effects of growth differentiation factor 11 (GDF11) on isoproterenol (ISO)‑induced heart failure (HF) and identify the underlying molecular mechanisms." | 7.91 | Growth differentiation factor 11 is involved in isoproterenol‑induced heart failure. ( Hao, Z; Jia, Y; Li, N; Shi, ZF; Tan, H; Zhang, XJ, 2019) |
| " Myocardial infarction was induced in Wistar rats via isoproterenol injection in a dose of (85 mg/kg, subcutaneously, twice at an interval of 24 h)." | 7.88 | Novel Mesenchymal Stem Cell Strategy in Alleviating Toll-Like Receptor-4, p53 and Nrf2 Signaling in Isoproterenol-Induced Myocardial Infarction in Rat Model. ( Abdel-Megeed, RM; Kadry, MO, 2018) |
| "To investigate the effects and mechanisms of catalpol on cardiac function in rats with isoproterenol (ISO)-induced myocardial infarction (MI)." | 7.88 | Catalpol pretreatment attenuates cardiac dysfunction following myocardial infarction in rats. ( Bi, F; Sun, Q; Xu, Y, 2018) |
| "Isoproterenol is used widely for inducing heart failure in mice." | 7.88 | Isoproterenol-Induced Heart Failure Mouse Model Using Osmotic Pump Implantation. ( Chang, SC; Rau, CD; Ren, S; Wang, JJ, 2018) |
| "In this study, we applied different sizes of gold nanoparticles (Au-NPs) to isoproterenol (ISO)-induced hyperthyroid heart disease rats (HHD rats)." | 7.88 | Size dependent effects of Gold Nanoparticles in ISO-induced Hyperthyroid Rats. ( Ma, A; Ni, Y; Ning, F; Shang, L; Xue, Y; Zhang, J, 2018) |
| "To investigate the effect of dimethyl fumarate (DMF) on Toll-like receptor (TLR) signalling pathway in isoproterenol (ISO)-induced cardiac hypertrophy in rats." | 7.88 | Dimethyl fumarate interferes with MyD88-dependent toll-like receptor signalling pathway in isoproterenol-induced cardiac hypertrophy model. ( Ahmed, AA; Ahmed, AAE; El Morsy, EM; Nofal, S, 2018) |
| "To evaluate the effect of oltipraz (OPZ) on isoproterenol-induced heart failure (HF) and heart function." | 7.88 | Oltipraz attenuates the progression of heart failure in rats through inhibiting oxidative stress and inflammatory response. ( Guo, M; Hao, MH; Ma, XY; Sun, WP; Tang, Y; Zhu, HY, 2018) |
| "The present study investigated the protective effect of diethylcarbamazine in inhibiting nuclear factor (NF)-κB activation in isoproterenol‑induced acute myocardial infarction (AMI) rats through the poly ADP ribose polymerase (PARP) pathway." | 7.85 | Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway. ( Jia, G; Liu, X; Zao, M, 2017) |
| ", family Arecaceae) on isoproterenol-induced myocardial infarction (MI) in rats." | 7.85 | Cardiopreventive effect of ethanolic extract of Date Palm Pollen against isoproterenol induced myocardial infarction in rats through the inhibition of the angiotensin-converting enzyme. ( Abid, L; Ayadi, F; Belbahri, L; Ben Amar, R; Ben Mefteh, F; Daoud, A; ElFeki, A; Gharsallah, N; Jmal, S; Kadri, A; Mnafgui, K; Rateb, ME; Turki, M, 2017) |
| "The present study was designed to evaluate the cardioprotective effects of nesfatin-1, a novel peptide with anorexigenic properties, in rats with isoproterenol (ISO)-induced myocardial infarction (MI), and to further investigate the role of Akt/GSK-3β signaling pathway in the protective effect of nesfatin-1." | 7.85 | Cardioprotective effect of nesfatin-1 against isoproterenol-induced myocardial infarction in rats: Role of the Akt/GSK-3β pathway. ( Adiguzel, D; Barutcigil, A; Celik-Ozenci, C; Dalaklioglu, S; Kuscu, N; Ozdem, S; Tasatargil, A, 2017) |
| " macroptera peel and pulp against isoproterenol (ISO)-induced myocardial infarction (MI) in rats." | 7.85 | Protective effects of ethanolic peel and pulp extracts of Citrus macroptera fruit against isoproterenol-induced myocardial infarction in rats. ( Afroz, R; Das, S; Gan, SH; Hossain, MS; Hossen, MS; Ibrahim Khalil, M; Islam, MA; Paul, S; Saha, M; Tanvir, EM, 2017) |
| " The present study was intended to appraise the nutraceutical inherent of HPLC standardized Spinacia oleracea methanolic leaf extract (SoLE) in isoproterenol (ISO) induced male albino Wistar rats via activation of pro-inflammatory signaling pathway that drives myocardial necrosis." | 7.85 | Nutraceutical inherent of Spinacia oleracea Linn. methanolic leaf extract ameliorates isoproterenol induced myocardial necrosis in male albino Wistar rats via mitigating inflammation. ( Jolapuram, U; Kodidhela, LD; Vutharadhi, S, 2017) |
| "Male Sprague Dawley rats were given isoproterenol 5 mg/kg once a day for 7 days to establish heart failure model by subcutaneous injection." | 7.85 | Protective effects of low-dose rosuvastatin on isoproterenol-induced chronic heart failure in rats by regulation of DDAH-ADMA-NO pathway. ( Ma, P; Wang, Y; Xiong, A; Xu, Q; Xu, Y; Zhou, R, 2017) |
| " Here, we investigated the effect of CaMKII inhibition in isoproterenol (ISO)-induced arrhythmias in hypertrophic mice." | 7.85 | CaMKII inhibition reduces isoproterenol-induced ischemia and arrhythmias in hypertrophic mice. ( Cheng, J; Feng, Y; Wang, Y; Wei, B, 2017) |
| "This study aimed to evaluate the antithrombotic, anti-inflammatory and anti-cardiac remodeling properties of eugenol in isoproterenol-induced myocardial infarction in rats." | 7.83 | Anti-inflammatory, Antithrombotic and Cardiac Remodeling Preventive Effects of Eugenol in Isoproterenol-Induced Myocardial Infarction in Wistar Rat. ( Allouche, N; Derbali, F; Ellefi, H; Gammoudi, A; Gharsallah, N; Hajji, R; Kadri, A; Khabbabi, G; Mnafgui, K, 2016) |
| "This study was aimed to investigate the possible inhibitory effects of aliskiren (ALS) and/or carvedilol (CAV) on CaMKIIδ isoforms expression in experimental cardiac hypertrophy." | 7.83 | Effect of aliskiren and carvedilol on expression of Ca(2+)/calmodulin-dependent protein kinase II δ-subunit isoforms in cardiac hypertrophy rat model. ( Abdel Baky, NA; Al-Mohanna, F; Bin-Dayel, AF; Fadda, LM; Mohammad, RA, 2016) |
| "Isoproterenol infusions generated significant cardiac fibrosis (p < 0." | 7.83 | Paricalcitol Attenuates Cardiac Fibrosis and Expression of Endothelial Cell Transition Markers in Isoproterenol-Induced Cardiomyopathic Rats. ( Cheng, PW; Hsiao, M; Lai, CC; Liou, JC; Liu, CP; Lu, PJ; Lu, WH; Sun, GC; Tseng, CJ, 2016) |
| "We aimed to understand the genetic control of cardiac remodeling using an isoproterenol-induced heart failure model in mice, which allowed control of confounding factors in an experimental setting." | 7.83 | Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. ( Avetisyan, R; Gong, KW; Lusis, AJ; Rau, C; Ren, S; Romay, MC; Stolin, G; Wang, JJ; Wang, Y, 2016) |
| "The aim of the present study was to confirm the effect of Tanshinone IIA (TAN) on the prevention of AF in chronic heart failure (CHF), and to elucidate the underlying electrophysiological mechanisms for the antiarrhythmic effects of TAN at the level of the atrium in an experimental model of CHF." | 7.83 | Reduction of atrial fibrillation by Tanshinone IIA in chronic heart failure. ( Cheng, D; He, Z; Sun, C; Xu, Y, 2016) |
| "The effects of benidipine on oxidative stress and myocardial apoptosis were assessed in isoproterenol (ISO)-induced myocardial infarction (MI) in wistar rats." | 7.81 | Benidipine prevents oxidative stress, inflammatory changes and apoptosis related myofibril damage in isoproterenol-induced myocardial infarction in rats. ( Akhtar, M; Akhtar, MS; Ali, J; Ansari, SH; Haque, SE; Hassan, MQ; Najmi, AK, 2015) |
| " Therefore because oxidative stress plays a significant role in the pathophysiology of myocardial infarction (MI), the aim of our study was to investigate whether hydrogen-rich saline has cardioprotective effects against isoproterenol-induced MI in rats." | 7.81 | Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats. ( Han, JJ; Jing, L; Qin, SC; Sun, XJ; Wang, Y; Zhao, B; Zhao, XM, 2015) |
| "Combined effects of vincristine and quercetin in the regulation of isoproterenol (ISO)-induced cardiac necrosis have been evaluated in rats." | 7.81 | Combined Effects of Vincristine and Quercetin in Reducing Isoproterenol-Induced Cardiac Necrosis in Rats. ( Kar, A; Panda, S, 2015) |
| "This study was aimed to evaluate the preventive role of phytic acid on lysosomal enzymes in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats." | 7.81 | Preventive effect of phytic acid on lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats. ( Brindha, E; Rajasekapandiyan, M, 2015) |
| "In this study, we evaluated ET effects on isoproterenol (ISO)-induced cardiac hypertrophy in female mice." | 7.81 | Nitric oxide synthase inhibition abolishes exercise-mediated protection against isoproterenol-induced cardiac hypertrophy in female mice. ( Li, J; Liu, J; Lu, P; Qi, Z; Ren, J; Tian, W; Yang, L; Zhu, M, 2015) |
| " alata (LPva) in isoproterenol (ISO)-induced myocardial infarction (MI) in rats." | 7.81 | Protective effects of Labisia pumila var. alata on biochemical and histopathological alterations of cardiac muscle cells in isoproterenol-induced myocardial infarction rats. ( Amran, AZ; Dianita, R; Jalil, J; Jantan, I, 2015) |
| "The present study was designed to evaluate the cardioprotective potential of edaravone on oxidative stress, anti-apoptotic, anti-inflammatory and ultrastructure findings in isoproterenol (ISO) induced myocardial infarction (MI) in rats." | 7.81 | Edaravone protects rats against oxidative stress and apoptosis in experimentally induced myocardial infarction: Biochemical and ultrastructural evidence. ( Akhtar, M; Akhtar, MS; Ali, J; Haque, SE; Hassan, MQ; Najmi, AK, 2015) |
| " The present study was designed to investigate the effect of pretreatment with SIM on isoproterenol (ISO)-induced cardiac hypertrophy in rats." | 7.81 | Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway. ( Al-Manee, RZ; Al-Oteibi, MM; Al-Rasheed, NM; Al-Shareef, SA; Hasan, IH; Mahmoud, AM; Mohamad, RA, 2015) |
| "This study aimed to explore the effects of puerarin on autophagy in cardiac hypertrophy." | 7.81 | Puerarin prevents cardiac hypertrophy induced by pressure overload through activation of autophagy. ( Chen, M; Huang, Z; Li, Y; Liu, B; Liu, P; Luo, C; Ou, C; Wu, Z; Zhang, J, 2015) |
| "Although it is well known that isoproterenol (ISO) causes myocardial hypertrophy and myocardial fibrosis in rats, it has remained elusive whether heat shock factor 1 (HSF1) has a role in this process." | 7.81 | Roles of heat shock factor 1 in isoproterenol‑induced myocardial fibrosis in mice. ( Fang, L; Xie, Y; Zhang, B; Zhang, L, 2015) |
| "The aim of the present study was to investigate the cardioprotective effects of Timosaponin B II (TB), a main bioactive constituent from Anemarrhenae asphodeloides Bge, on an isoproterenol (ISO)-induced myocardial infarction model in rats and explore its underlying mechanisms." | 7.81 | Cardioprotective effects of timosaponin B II from Anemarrhenae asphodeloides Bge on isoproterenol-induced myocardial infarction in rats. ( Chen, JJ; Deng, XY; Fu, Q; Li, HY; Ma, SP; Ma, ZQ, 2015) |
| " Electrocardiography on isoproterenol challenged mice showed that both models developed arrhythmias and died within 24 hours, while wild-type mice were free of pathology." | 7.81 | Selective Connexin43 Inhibition Prevents Isoproterenol-Induced Arrhythmias and Lethality in Muscular Dystrophy Mice. ( Contreras, JE; Fraidenraich, D; Gonzalez, JP; Ramachandran, J; Xie, LH, 2015) |
| " The current study investigated the effect of cardamom on hemodynamic, biochemical, histopathological and ultrastructural changes in isoproterenol (ISO)-induced myocardial infarction." | 7.81 | Protective Effects of Cardamom in Isoproterenol-Induced Myocardial Infarction in Rats. ( Agrawal, YO; Arya, DS; Goyal, SN; Kumari, S; Mahajan, UB; Ojha, S; Patil, CR; Sharma, C, 2015) |
| "We have previously shown that pentoxifylline (PTX) protects from vascular complications associated with insulin resistance (IR)." | 7.80 | Pentoxifylline alleviates cardiac ischemia and dysfunction following experimental angina in insulin resistance. ( Azhar, A; El-Bassossy, HM, 2014) |
| "Our data suggest that tamoxifen produces beneficial effects on cardiac hypertrophy and hence may be considered as a preventive measure for cardiac hypertrophy." | 7.80 | Beneficial role of tamoxifen in experimentally induced cardiac hypertrophy. ( Desai, VJ; Patel, BM, 2014) |
| "The physiological mechanisms involved in isoproterenol (ISO)-induced chronic heart failure (CHF) are not fully understood." | 7.80 | Changes in cardiac aldosterone and its synthase in rats with chronic heart failure: an intervention study of long-term treatment with recombinant human brain natriuretic peptide. ( Chen, LL; Hong, HS; Li, YH; Lin, XH; Zhu, XQ, 2014) |
| "Scutellarin (SCU) is the major active component of breviscapine and has been reported to be capable of decreasing myocardial fibrosis." | 7.80 | Anti-fibrosis effect of scutellarin via inhibition of endothelial-mesenchymal transition on isoprenaline-induced myocardial fibrosis in rats. ( Cai, J; Chen, L; Chen, X; Huang, W; Zhang, H; Zheng, G; Zhou, H; Zhou, X, 2014) |
| "The present study was designed to investigate whether oxymatrine could attenuate isoproterenol-induced heart failure via regulation of asymmetric dimethylarginine (ADMA) metabolism in rats." | 7.80 | Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in rats. ( Dai, G; Liu, J; Liu, YK; Wang, X; Wang, Y; Xu, Q; Xu, X; Zhang, J; Zhang, W, 2014) |
| "The present study aimed at using a proteomics based approach to: a) analyze and contrast the proteome of the healthy and isoproterenol induced hypertrophied hearts and b) identify potential biomarkers for diagnosis of cardiac hypertrophy." | 7.79 | A proteomic view of isoproterenol induced cardiac hypertrophy: prohibitin identified as a potential biomarker in rats. ( Banerjee, SK; Bhadra, MP; Chowdhury, D; Khatua, TN; Saxena, P; Tangutur, AD, 2013) |
| " In the present study, we evaluated the effects of metformin on cardiac function, hemodynamic parameters, and histopathological changes in isoproterenol-induced myocardial infarction (MI)." | 7.78 | Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats. ( Garjani, A; Khorrami, A; Maleki-Dizaji, N; Soraya, H, 2012) |
| "To assess the protective effects of lycopene on electrocardiographic, hemodynamic, biochemical and apoptotic changes in isoproterenol induced myocardial infarction." | 7.78 | Tomato lycopene attenuates myocardial infarction induced by isoproterenol: electrocardiographic, biochemical and anti-apoptotic study. ( Aman, U; Balaraman, R; Vaibhav, P, 2012) |
| "The aim of this investigation was to evaluate the preventive role of morin, a flavonoid, on cardiac marker enzymes such as aspartate transaminase, lactate dehydrogenase, creatine kinase and creatine kinase-MB, membrane-bound enzymes such as sodium potassium-dependent adenosine triphosphatase, calcium-dependent adenosine triphosphatase and magnesium-dependent adenosine triphosphatase, and glycoproteins such as hexose, hexosamine, fucose and sialic acid in isoproterenol (ISO)-induced myocardial infarction (MI) in rats." | 7.78 | Pretreatment with morin, a flavonoid, ameliorates adenosine triphosphatases and glycoproteins in isoproterenol-induced myocardial infarction in rats. ( Al-Numair, KS; Alsaif, MA; Chandramohan, G, 2012) |
| "The present investigation was to evaluate the antioxidant, biochemical profile and histological studies of qualitatively standardized ethanolic extract of Terminalia pallida fruits (TpFE) against isoproterenol-induced myocardial infarction in rats." | 7.78 | Cardioprotective effect of HPLC standardized ethanolic extract of Terminalia pallida fruits against isoproterenol-induced myocardial infarction in albino rats. ( Abdul Kareem, M; Lakshmi Devi, K; Rasool, SN; Saayi Krushna, G; Shaik, AH; Vikram Kumar Reddy, A, 2012) |
| "Castration significantly increased cardiomyocyte apoptosis and fibrosis that was normally induced by isoproterenol (P<0." | 7.78 | Testosterone improves cardiac function and alters angiotensin II receptors in isoproterenol-induced heart failure. ( Cao, JX; Fu, L; Han, Y; Kang, NN; Sun, JF; Xu, J; Zheng, M, 2012) |
| "Although spironolactone and telmisartan are reported to reduce the risk of morbidity and death, direct studies on their effects on isoproterenol-induced cardiac hypertrophy are scanty." | 7.78 | Beneficial role of spironolactone, telmisartan and their combination on isoproterenol-induced cardiac hypertrophy. ( Goyal, BR; Mehta, AA, 2012) |
| "Ranolazine (RAN) was reported to be effective and safe in converting atrial fibrillation (AF) to sinus rhythm by administration of a single dose ('pill in the pocket') to patients with structural heart disease." | 7.78 | Further insights into the underlying electrophysiological mechanisms for reduction of atrial fibrillation by ranolazine in an experimental model of chronic heart failure. ( Clauß, C; Eckardt, L; Frommeyer, G; Kaese, S; Milberg, P; Pott, C; Schmidt, M; Stypmann, J, 2012) |
| "The present study demonstrated prophylactic and therapeutic potential of Terminalia arjuna bark extract in isoproterenol (ISO)-induced chronic heart failure (CHF)." | 7.77 | Mechanistic clues in the cardioprotective effect of Terminalia arjuna bark extract in isoproterenol-induced chronic heart failure in rats. ( Agarwal, S; Babbar, R; Fahim, M; Kotwani, A; Parveen, A, 2011) |
| "To compare the potency and ureteral selectivity of the selective β(2)/β(3)-adrenoceptor agonist KUL-7211 with those of the nonselective β-adrenoceptor agonist isoproterenol, selective β(2)-adrenoceptor agonist terbutaline, and selective β(3)-adrenoceptor agonist CL-316243, we performed the study using an isolated porcine ureter and a porcine model of acute unilateral ureteral obstruction." | 7.77 | Ureteral selectivity of intravenous β-adrenoceptor agonists in pig model of acute ureteral obstruction: comparison of KUL-7211, a selective β2/β3 agonist, with isoproterenol, terbutaline, and CL-316243. ( Kojima, M; Tomiyama, Y; Wanajo, I; Yamazaki, Y, 2011) |
| "Heart failure was induced by isoproterenol in male Sprague-Dawley rats." | 7.77 | Icariin attenuates cardiac remodelling through down-regulating myocardial apoptosis and matrix metalloproteinase activity in rats with congestive heart failure. ( Cai, H; Cao, SP; Gu, N; Qian, CF; Song, YH; Zhao, ZM, 2011) |
| "The present study was designed to investigate the cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats by studying myocyte injury markers, antioxidant defense system, serum and heart lipid profile, inflammatory markers, electrocardiographic and histopathological changes." | 7.76 | Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: A biochemical, electrocardiographic and histoarchitectural evaluation. ( Balaraman, R; Patel, V; Upaganlawar, A; Zalawadia, R, 2010) |
| "The present study was undertaken to evaluate the preventive role of naringin on mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats." | 7.75 | Naringin ameliorates mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol-induced myocardial infarction in Wistar rats. ( Prince, PS; Rajadurai, M, 2009) |
| " This study was designed to evaluate the protective effect of gallic acid on cardiac marker enzymes, troponin-T, LDH-isoenzyme pattern, lipid peroxidation products and antioxidant status in isoproterenol (ISO)-induced myocardial infarction in male Wistar rats." | 7.75 | Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats. ( Prince, PS; Priscilla, DH, 2009) |
| "The study aimed to evaluate the protective role of myricetin obtained from Vitis vinifera (Vitaceae) on heart rate, electrocardiographic (ECG) patterns, vascular reactivity to catecholamines, cardiac marker enzymes, antioxidant enzymes together with morphological and histopathological changes in isoproterenol (ISO) induced myocardial infarction (MI) in male Wistar rats." | 7.75 | Cardioprotective potential of myricetin in isoproterenol-induced myocardial infarction in Wistar rats. ( Ballero, M; Kasture, S; Maxia, A; Mohan, M; Tiwari, R, 2009) |
| "Our study demonstrates the contribution of IL-17 to myocardial fibrosis in isoproterenol-induced HF." | 7.75 | IL-17 induces myocardial fibrosis and enhances RANKL/OPG and MMP/TIMP signaling in isoproterenol-induced heart failure. ( Feng, W; Li, W; Li, Y; Liu, W; Wang, F; Yan, W, 2009) |
| "To study the protective effect of Buyanghuanwu Decoction on myocardial ischemia induced by isoproterenol in rats." | 7.75 | [Protective effect of Buyanghuanwu Decoction on myocardial ischemia induced by isoproterenol in rats]. ( Ji, QL; Lin, R; Liu, Y; Yang, YJ; Zhang, H; Zhang, JY, 2009) |
| "We demonstrated that propranolol reduced the incidence of arrhythmias in a rat model of myocardial infarction by coronary artery occlusion." | 7.75 | MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotection. ( Dong, D; Li, B; Li, X; Lu, Y; Pan, Z; Qiao, G; Shan, H; Song, W; Xu, C; Yang, B; Zhang, B; Zhang, F; Zhang, Y, 2009) |
| " The present study has been designed to investigate whether telmisartan treatment attenuates the development of acute myocardial infarction in isoproterenol-treated rats by restoring hemodynamic, biochemical, histopathological and ultrastructural changes." | 7.75 | Myocardial salvaging effect of telmisartan in experimental model of myocardial infarction. ( Arora, S; Arya, DS; Goyal, S; Joshi, S; Kumari, S; Mittal, R; Nag, TC; Ray, R, 2009) |
| "Isoproterenol-induced cardiac hypertrophy in mice has been used in a number of studies to model human cardiac disease." | 7.75 | Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure. ( Errami, M; Galindo, CL; Garner, HR; Kumar, NM; Li, J; McCormick, JF; McIver, LJ; Olson, LD; Pham, TQ; Skinner, MA; Watson, DA, 2009) |
| "A recent clinical study has shown that carvedilol has a significantly more favorable effect than metoprolol on survival rate in patients with heart failure." | 7.74 | Comparison of pharmacodynamics between carvedilol and metoprolol in rats with isoproterenol-induced cardiac hypertrophy: effects of carvedilol enantiomers. ( Asari, K; Hanada, K; Kawana, J; Mita, M; Ogata, H; Saito, M, 2008) |
| "Heart failure (HF) may be produced by sustained beta-adrenoceptor stimulation by causing changes in the expression of endothelin-1 (ET-1), the leptin system, calcineurin and sarcoplasmic reticulum Ca2+ ATPase 2a (SERCA2a) underlying cardiac dysfunction." | 7.74 | Protective effect of the endothelin antagonist CPU0213 against isoprenaline-induced heart failure by suppressing abnormal expression of leptin, calcineurin and SERCA2a in rats. ( Dai, DZ; Dai, Y; Ji, H; Tang, XY; Xu, M, 2008) |
| "1 The purpose of this study was to examine the effect of inhibition of the formation of cytochrome P450 metabolites of arachidonic acid with 1-aminobenzotriazole (ABT) on the development of hypertension and end-organ damage in spontaneously hypertensive rats (SHR) chronically treated with nitric oxide synthesis inhibitor L-NAME (SHR-L-NAME)." | 7.73 | Contribution of cytochrome P450 metabolites of arachidonic acid to hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME. ( Benter, IF; Canatan, H; Cojocel, C; Francis, I; Juggi, JS; Yousif, MH, 2005) |
| "To examine the negative regulation role of PTEN in isoproterenol-induced cardiac hypertrophy by testing the expression of PTEN mRNA and protein and to explore the effects of captopril (Cap) on PTEN expression." | 7.73 | [PTEN negatively regulates isoproterenol-induced cardiac hypertrophy and effects of captopril on PTEN expression]. ( Tian, Y; Wang, J; Yu, LJ; Zhou, YZ; Zhu, SJ, 2005) |
| "Gene expression of heparanase, matrix metalloproteinases (MMP)-2 and MMP-9 were examined in ventricles after chronic treatment with isoproterenol (ISO) induced cardiac hypertrophy in rats." | 7.73 | Induction of heparanase gene expression in ventricular myocardium of rats with isoproterenol-induced cardiac hypertrophy. ( Hara, Y; Hashizume, K; Ito, R; Kizaki, K; Mutoh, K; Okada, M; Yoshioka, K, 2005) |
| "Isoproterenol-induced cardiac hypertrophy is associated with increased expression of endothelial nitric oxide synthase in the aorta but without signs of improved endothelial function." | 7.73 | Increased expression of endothelial nitric oxide synthase and caveolin-1 in the aorta of rats with isoproterenol-induced cardiac hypertrophy. ( Fecenkova, A; Gazova, A; Klimas, J; Krenek, P; Kroslakova, M; Kucerova, D; Kyselovic, J; Plandorova, J; Svec, P, 2006) |
| " Cardiac lesions induced by isoproterenol (ISO) are characterized by myocardial necrosis and exudative infiltration." | 7.72 | Effect of D-003 on isoproterenol-induced myocardial necrosis in rats. ( Arruzazabala, ML; Carbajal, D; González, J; Más, R; Mendoza, S; Molina, V; Noa, M, 2003) |
| "The protective effect of L-arginine and L-lysine on lysosomal enzymes and membrane bound ATPases was examined on isoproterenol induced myocardial infarction in rats." | 7.72 | Effect of L-arginine and L-lysine on lysosomal hydrolases and membrane bound phosphatases in experimentally induced myocardial infarction in rats. ( Devaki, T; Ebenezar, KK; Sathish, V, 2003) |
| "Animals with heart failure exhibited depressions in ventricular function, positive inotropic response to isoproterenol, beta-AR receptor density and basal AC activity; these changes were also attenuated by PLC treatment." | 7.72 | Improvement of cardiac function and beta-adrenergic signal transduction by propionyl L-carnitine in congestive heart failure due to myocardial infarction. ( Dhalla, NS; Ferrari, R; Sethi, R; Wang, X, 2004) |
| "Myocardial infarction was produced by subcutaneous administration of isoproterenol hydrochloride (85 mg/kg b." | 7.72 | Comparative account of certain enzymes in the serum of homo-iothermal vertebrates subjected to production of myocardial infarction by isoproterenol hydrochloride. ( Gaur, M; Kumar, S, 2003) |
| "Furosemide shortened the time to left ventricular dysfunction (35." | 7.72 | Furosemide and the progression of left ventricular dysfunction in experimental heart failure. ( Haigney, MC; Hanlon, SU; McCurley, JM; Michalski, M; Wedam, EF; Wei, SK, 2004) |
| "In rats, a toxic dosage of isoproterenol caused characteristic myocardial damage that subsequently resulted in mild heart failure." | 7.70 | Development of heart failure following isoproterenol administration in the rat: role of the renin-angiotensin system. ( Bruckschlegel, G; Elsner, D; Griese, D; Grimm, D; Kromer, EP; Muders, F; Pfeifer, M; Riegger, GA; Schunkert, H, 1998) |
| "This study demonstrates that isoproterenol-induced myocardial necrosis resulted in progressive hemodynamic dysfunction of the left ventricle which most closely correlated with alterations in LV geometry." | 7.70 | Effect of left ventricular sphericity on the evolution of ventricular dysfunction in rats with diffuse isoproterenol-induced myocardial necrosis. ( Pfeffer, JM; Pfeffer, MA; Teerlink, JR, 1998) |
| "Isoproterenol hydrochloride (ISO), a beta adrenergic agonist, is known to cause ischemic necrosis in rats." | 7.70 | Effect of a novel tetrapeptide derivative in a model of isoproterenol induced myocardial necrosis. ( Jayakumar, R; Jayasundar, S; Malarvannan, P; Puvanakrishnan, R; Ramesh, CV, 1998) |
| "The aim was to compare the effects of two novel angiotensin converting enzyme (ACE) inhibitors, spirapril and zofenopril, on cardiac remodelling in rats with congestive heart failure after myocardial infarction." | 7.68 | Converting enzyme inhibition after experimental myocardial infarction in rats: comparative study between spirapril and zofenopril. ( de Graeff, PA; de Langen, CD; Pinto, YM; van Gilst, WH; van Wijngaarden, J; Wesseling, H, 1991) |
| "After antenatal induction of diaphragmatic hernias in fetal lambs, prostaglandins D2, E1, and I2 were compared to tolazoline, or isoprenaline, for the treatment of pulmonary hypertension." | 7.68 | Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline. ( Barker, AP; Ford, WD; Lee, CM; Sen, S, 1990) |
| "Two experimental animal models exhibiting functional and morphologic changes of exocrine glands similar to those seen in patients with cystic fibrosis (CF) have been reported in the rat: chronic stimulation with reserpine (Martinez et al." | 7.67 | Pulmonary function of the reserpine and isoproterenol models of cystic fibrosis. ( Boyd, RL; Fletcher, MT; Francis, EM; Mangos, JA, 1984) |
| "The chronically isoproterenol-treated rat has been proposed as an animal model for cystic fibrosis." | 7.67 | The chronically isoproterenol-treated rat in the study of cystic fibrosis: X-ray microanalysis of the submandibular gland. ( Müller, RM; Roomans, GM, 1984) |
| "Effects of prazosin, dobutamine, isoproterenol and SGB-1534, a new alpha-blockade, on congestive heart failure (CHF) in dogs were investigated." | 7.67 | [Effects of prazosin, SGB-1534, dobutamine and isoproterenol on congestive heart failure in dogs]. ( Sonoki, H; Sugimoto, T; Tomaru, T; Uchida, Y, 1988) |
| " To separately evaluate the ability of isoproterenol, a beta-adrenergic agonist, to prevent mediator release and anaphylactic shock, as well as to reverse the cardiopulmonary manifestations of systemic anaphylaxis, we administered a continuous infusion of isoproterenol before and during canine anaphylactic shock." | 7.67 | Prevention of canine anaphylaxis with isoproterenol. ( Bleecker, ER; Kagey-Sobotka, A; Lichtenstein, LM; Silverman, HJ; Smith, PL; Taylor, WR, 1986) |
| "Heavy male Sprague-Dawley rats die of ventricular fibrillation within 2 to 3 h after isoproterenol administration." | 7.67 | Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death. ( Balazs, T; Ehrreich, SJ; el-Hage, AN; Johnson, GL, 1986) |
| "Ventricular fibrillation threshold was determined using a train of pulses, 4 ms in duration, delivered at 10 ms intervals, in 20 anaesthetised dogs receiving toxic doses of quinidine sulphate (30 mg X kg-1) injected intravenously over 5 min to prolong the QT interval." | 7.67 | Ventricular fibrillation threshold in canine hearts with quinidine induced prolonged QT interval: effects of atrial pacing, isoproterenol, and lignocaine. ( Inoue, H; Mashima, S; Matsuo, H; Murao, S; Sugimoto, T, 1986) |
| "A high incidence of sudden death due to ventricular fibrillation (VF) has been observed in dogs under chronic treatment with probucol, a new hypocholesterolemic agent." | 7.66 | Adrenergaically mediated ventricular fibrillation in probucol-treated dogs: roles of alpha and beta adrenergic receptors. ( Besch, HR; Elharrar, V; Molello, J; Watanabe, AM; Zipes, DP, 1979) |
| "Adrenoceptor-mediated responses of the cardiovascular system during propylthiouracil-induced hypothyroidism were investigated." | 7.66 | Changes of adrenoceptor-mediated responses in the pithed rat during propylthiouracil-induced hypothyroidism. ( Borowski, E; Gross, G; Schümann, HJ, 1979) |
| "The effect of timolol, propranolol, epinephrine, and isoproterenol on intraocular pressure (IOP) (measured by tonometry) were compared after topical administration in conscious rabbits." | 7.65 | Comparison of the effects of timolol and other adrenergic agents on intraocular pressure in the rabbit. ( Le Douarec, JC; Plazonnet, B; Sears, ML; Silverstone, D; Stone, CA; Vareilles, P, 1977) |
| "Elevated calcium and protein concentration are a consistent abnormality in submaxillary saliva from patients with cystic fibrosis (CF) and from experimental animal models developed by the chronic administration of either isoproterenol (IPR) or reserpine." | 7.65 | The chronically reserpinized rat as a possible model for cystic fibrosis. VI. Synergistic effects of isoproterenol on Ca++ and protein in the submaxillary gland. ( Martinez, R; Wood, DL, 1977) |
| "Trapidil increases the isoprenalin-induced necrosis of the myocardium in the rat." | 7.65 | [Modification of the isoprenaline-induced myocardial necrosis using trapidil]. ( Lampe, D; Lange, B; Mai, I, 1976) |
| "Male and female, arteriosclerotic and nonarteriosclerotic rats were subjected to acute myocardial infarction by two, subcutaneous injections (spaced 24 hr apart) of isoproterenol." | 7.65 | Metabolic and histopathologic changes in arteriosclerotic versus nonarteriosclerotic rats following isoproterenol-induced myocardial infarction with superimposed diabetes. ( Wexler, BC, 1975) |
| "Rats were injected with ISO to induce cardiac hypertrophy and treated with MCP." | 5.62 | Modified citrus pectin prevents isoproterenol-induced cardiac hypertrophy associated with p38 signalling and TLR4/JAK/STAT3 pathway. ( Li, AY; Li, Y; Liu, WZ; Liu, XC; Song, QH; Sun, JH; Xu, GR; Yang, HX; Zhang, C; Zhang, Y; Zhou, WW, 2021) |
| "Ferruginol (FGL) is a major polyphenols and terpenoids with numerous pharmacological activities including antioxidant and anti-inflammatory." | 5.62 | Ameliorative effect of ferruginol on isoprenaline hydrochloride-induced myocardial infarction in rats. ( Ali Alharbi, S; Chen, Y; Deng, Y; Feng, J; Li, H; Li, X; Wang, C; Wang, L; Zhang, X, 2021) |
| "Cardiac fibrosis is a crucial aspect of cardiac remodeling that can severely affect cardiac function." | 5.51 | Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats. ( Che, Y; Jin, YG; Shen, DF; Wang, SS; Wang, ZP; Wu, QQ; Yuan, Y, 2019) |
| "Isoproterenol (ISO), is a non-selective beta-adrenergic agonist, that is used widely to induce cardiac injury in mice." | 5.51 | Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice. ( Chang, S; Mandelli, A; Ren, S; Tran, A; Wang, JJ; Wang, Y, 2019) |
| "Plantamajoside (PMS) is an active component extracted from Herba Plantaginis, which is a traditional Chinese medicine, and many biological activities of PMS have been reported." | 5.51 | Plantamajoside attenuates isoproterenol-induced cardiac hypertrophy associated with the HDAC2 and AKT/ GSK-3β signaling pathway. ( Hou, M; Liu, Y; Pin, L; Shang, L; Shun, M; Zhang, Y; Zhong, X; Zhu, S, 2019) |
| "Cardiac fibrosis is a common feature of many cardiac pathophysiologic conditions." | 5.48 | Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome. ( Qi, R; Tuerdi, N; Wan, Y; Wang, Y; Xu, L; Ye, M, 2018) |
| " At the end of dosing left ventricular functions was assessed to estimate its effect on cardiac functions." | 5.46 | Cardiaprotective effect of crocetin by attenuating apoptosis in isoproterenol induced myocardial infarction rat model. ( Ge, Z; Li, Y; Zhang, W, 2017) |
| "Isorhapontigenin is a derivative of stilbene with chemical structure similar to resveratrol." | 5.43 | Cardioprotective effect of resveratrol analogue isorhapontigenin versus omega-3 fatty acids in isoproterenol-induced myocardial infarction in rats. ( Abbas, AM, 2016) |
| "Zingerone pretreatment significantly (P<0." | 5.43 | Anti-inflammatory and anti-thrombotic effects of zingerone in a rat model of myocardial infarction. ( Hemalatha, KL; Stanely Mainzen Prince, P, 2016) |
| "Gallic acid pretreatment attenuated concentric cardiac hypertrophy." | 5.43 | Gallic acid prevents isoproterenol-induced cardiac hypertrophy and fibrosis through regulation of JNK2 signaling and Smad3 binding activity. ( Cho, JY; Choi, SY; Jeong, MH; Jin, L; Kee, HJ; Kim, GR; Lin, MQ; Piao, ZH; Ryu, Y, 2016) |
| " In conclusion, the present study indicated that chronic use of KATP channel agonists following cardiac hypertrophy can attenuate ventricular remodeling and upregulate the expression level and spatial distribution of Cx43." | 5.42 | Reduction of isoproterenol-induced cardiac hypertrophy and modulation of myocardial connexin43 by a KATP channel agonist. ( Gu, J; Guo, Z; Hao, YY; Sun, JM; Wang, AL; Wang, CM; Xie, YJ, 2015) |
| "Isoproterenol (100 mg/kg) was injected subcutaneously for two consecutive days to induce myocardial infarction, and simultaneously tacrolimus was administered orally twice a day for three days." | 5.40 | Tacrolimus ameliorates functional disturbances and oxidative stress in isoproterenol-induced myocardial infarction. ( Garjani, A; Garjani, M; Hammami, M; Khorrami, A; Maleki-Dizaji, N, 2014) |
| "ISO-induced cardiac hypertrophy and Erk1/2 activation in Pak-1-KO/ISO were attenuated when the selective Erk1/2 inhibitor FR180204 was administered." | 5.37 | Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. ( Chernoff, J; Ke, Y; Knezevic, I; Lei, M; Monasky, MM; Sheehan, KA; Solaro, RJ; Taglieri, DM; Wang, X; Wolska, BM, 2011) |
| "Pretreatment with mangiferin (100 mg/kg body weight, intraperitoneally) for 28 days, significantly prevented the alterations and restored the enzyme activities to near-normal status." | 5.35 | Mechanism of protective action of mangiferin on suppression of inflammatory response and lysosomal instability in rat model of myocardial infarction. ( Devi, CS; Narayan, S; Prabhu, S, 2009) |
| "Isoproterenol treatment (80 mg/kg given over 2 days in two equal doses) caused arrhythmias and 60% mortality within 24 h of the last injection in the control group (C + ISO) group when compared with the saline control group (saline)." | 5.35 | Exercise training provides cardioprotection via a reduction in reactive oxygen species in rats submitted to myocardial infarction induced by isoproterenol. ( Barbosa, VA; Boeck, CR; Da Luz, G; Da Silva, S; De Pinho, RA; De Souza, CT; Frederico, MJ; Justo, SL; Medeiros, C; Silva, LA, 2009) |
| "Myocardial infarction is usually induced in small animals by means of invasive procedures: the aim of this study was to cause heart necrosis lesions by non-invasive means." | 5.32 | Myocardial infarction non-invasively induced in rabbits by administering isoproterenol and vasopressin: protective effects exerted by verapamil. ( Bertolini, B; Bonacina, E; Brenna, S; Pinelli, A; Tomasoni, L; Trivulzio, S; Vignati, S, 2004) |
| "Selegiline is a centrally acting sympatholytic agent with neuroprotective properties." | 5.31 | Selegiline improves cardiac sympathetic terminal function and beta-adrenergic responsiveness in heart failure. ( Dong, E; Kawai, H; Liang, CS; Shite, J; Stevens, SY, 2000) |
| "In previous work, we have shown that the chronic administration of verapamil, a calcium channel blocker, ameliorated the mortality, pathology, and biochemical alterations associated with acute murine Chagas' disease." | 5.28 | Effect of verapamil on the development of chronic experimental Chagas' disease. ( Bilezikian, JP; Factor, SM; Morris, SA; Tanowitz, HB; Weiss, LM; Wittner, M, 1989) |
| "The necrosis was confirmed by ECG changes, increased serum activities of AspAT, AlAT, GPT and LDH, and by histological examination." | 5.26 | A temporal profile of changes in myocardial manganese after isoprenaline induced cardiac necrosis in albino rats. ( Ahmad, M; Hasan, MZ; Jameel, SA; Kumar, S; Mathew, BM; Seth, TD, 1979) |
| " Here, we have investigated the effects and potential mechanisms of action of MgIG, with respect to myocardial fibrosis induced by isoproterenol (ISO) in mice." | 4.98 | Inhibition of myocardial hypertrophy by magnesium isoglycyrrhizinate through the TLR4/NF-κB signaling pathway in mice. ( Chu, L; Han, X; Ma, D; Song, T; Zhang, J; Zhang, X; Zhang, Y, 2018) |
| " However, researchers recently investigated the potential cardioprotective effects of taraxerol utilizing an isoproterenol (ISO)-induced cardiotoxicity model among Sprague Dawley rats." | 4.31 | Effects of Taraxerol on Oxidative and Inflammatory Mediators in Isoproterenol-Induced Cardiotoxicity in an Animal Model. ( Alam, A; Alkholifi, FK; Aodah, AH; Devi, S; Foudah, AI; Yusufoglu, HS, 2023) |
| "Inflammation can contribute to the initiation and progression of atrial fibrillation (AF), and pinocembrin can suppress downstream inflammatory cytokine production by inhibiting the inflammation pathway." | 4.12 | Pinocembrin alleviates the susceptibility to atrial fibrillation in isoproterenol-induced rats. ( Chen, X; Liu, Z; Wan, W; Yang, B; Ye, T; Yu, Y; Zhang, C, 2022) |
| "This study investigated the protective effects of Compound 21 (C21), the first specific non-peptide AT2 receptor agonist, on cardiac injury in rats with isoproterenol-induced heart failure in vivo and compared it with valsartan, an AT1 receptor antagonist." | 4.02 | The Protective Effects of Compound 21 and Valsartan in Isoproterenol-Induced Myocardial Injury in Rats. ( Ates, B; Colak, C; Ermis, N; Ozhan, O; Parlakpinar, H; Ulutas, Z; Vardi, N, 2021) |
| " In this study, we observed the high expression of MBNL1 in cardiac tissue and peripheral blood of an isoproterenol (ISO)-induced cardiac hypertrophy mouse model." | 4.02 | MBNL1 regulates isoproterenol-induced myocardial remodelling in vitro and in vivo. ( Liang, C; Luo, Y; Xu, Y; Zhang, T, 2021) |
| " This study investigated the therapeutic benefit of adding rosuvastatin to low-dose carvedilol in protection against myocardial infarction (MI)." | 4.02 | Rosuvastatin and low-dose carvedilol combination protects against isoprenaline-induced myocardial infarction in rats: Role of PI3K/Akt/Nrf2/HO-1 signalling. ( Awad, AS; Baraka, SA; El-Demerdash, E; El-Naga, RN; Elsherbini, DA; Tolba, MF, 2021) |
| " From day 6, the mice were injected with the nonselective β-agonist isoproterenol for 4 consecutive days to induce diastolic dysfunction and subendocardial fibrosis while maintaining systolic function." | 4.02 | Liver X Receptor Agonist AZ876 Induces Beneficial Endogenous Cardiac Lipid Reprogramming and Protects Against Isoproterenol-Induced Cardiac Damage. ( Beyhoff, N; Blumrich, A; Foryst-Ludwig, A; Goeritzer, M; Grune, J; Jaeger, C; Kasch, J; Kintscher, U; Klopfleisch, R; Luettges, K; Müller, OJ; Ritter, D; Smeir, E; Thiele, A, 2021) |
| " The study aims to understand the effect of arbutin on isoproterenol (ISO)-induced cardiac hypertrophy in mice." | 3.96 | Arbutin Attenuates Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting TLR-4/NF-κB Pathway in Mice. ( Alavala, S; Jerald, MK; Mir, SM; Nalban, N; Sangaraju, R; Sistla, R, 2020) |
| "This study aimed to investigate the anti-fibrotic effects of ghrelin in isoproterenol (ISO)-induced myocardial fibrosis and the underlying mechanism." | 3.96 | Chronic peripheral ghrelin injection exerts antifibrotic effects by increasing growth differentiation factor 15 in rat hearts with myocardial fibrosis induced by isoproterenol. ( Feng, L; Lin, P; Ren, Q; Wang, Q; Zhang, B, 2020) |
| "Our study is aimed at evaluating the effects of pretreatment with Poly(lactic-co-glycolic) acid nanoparticle loaded with resveratrol (RSV PLGA NPs) compared to conventional resveratrol (RSV) on isoproterenol (ISO) induced myocardial infarction (MI) in rats." | 3.96 | Protective role of poly(lactic-co-glycolic) acid nanoparticle loaded with resveratrol against isoproterenol-induced myocardial infarction. ( Hu, Y; Kumar, P; Mishra, A; Moktan, JB; Sreeharsha, N; Sun, L; Wang, L, 2020) |
| "The anti-hypertrophy effect of TMYX was validated in isoproterenol-induced cardiac hypertrophy model in C57BL/6 mice." | 3.96 | High content screening identifies licoisoflavone A as a bioactive compound of Tongmaiyangxin Pills to restrain cardiomyocyte hypertrophy via activating Sirt3. ( Baruscotti, M; Guo, R; Liu, H; Liu, N; Wang, Y; Zhang, H; Zhang, J; Zhao, L, 2020) |
| " This study aimed to evaluate protective effect of ergosterol (ER) on isoproterenol (ISO)-induced myocardial cardiotoxicity." | 3.96 | Ergosterol Attenuates Isoproterenol-Induced Myocardial Cardiotoxicity. ( Dai, C; Gao, Y; Jin, L; Li, S; Song, J; Xie, Q, 2020) |
| " We have provided experimental evidence showing the suppressive effects of the nonselective β-adrenoreceptor antagonist propranolol on hyperglycemia, inflammation, and brain injury in a rat model experiencing cerebral ischemia." | 3.96 | Effects of β-Adrenergic Blockade on Metabolic and Inflammatory Responses in a Rat Model of Ischemic Stroke. ( Chang, CY; Chen, CJ; Chen, WY; Kuan, YH; Liao, SL; Lin, SY; Wang, YY; Wu, CC, 2020) |
| " Doxorubicin (DOX) and Isoproterenol (ISO) induced cardiotoxicity in wistar albino rats." | 3.96 | Investigation on protective effect of Terminalia bellirica (Roxb.) against drugs induced cardiotoxicity in wistar albino rats. ( Chaudhary, R; Kumar S, S; Kumar, N; Kumar, P; Singh, L; Singh, R; Verma, R, 2020) |
| "This research was aimed to explore protective effects of allicin on rat model of myocardial infarction via JNK signaling pathway." | 3.96 | Protective Effects of Allicin on ISO-Induced Rat Model of Myocardial Infarction via JNK Signaling Pathway. ( Li, EZ; Li, XP; Liu, YF; Ma, L; Wei, LN; Xu, W; Zhao, J, 2020) |
| " In particular, compound 4i was found to be the most potent ACE inhibitor and was further studied for cardioprotective effects against isoproterenol (ISO)-induced myocardial infarction (MI) in rats." | 3.96 | Novel thiazole-pyrazolone hybrids as potent ACE inhibitors and their cardioprotective effect on isoproterenol-induced myocardial infarction. ( Su, G; Su, X; You, H, 2020) |
| "Puerarin has shown unique pharmacological effects on myocardial ischemia (MI)." | 3.96 | The cardioprotective effects of the new crystal form of puerarin in isoproterenol-induced myocardial ischemia rats based on metabolomics. ( Du, G; Gao, Z; Li, M; Lv, Y; Qin, X; Shi, Y; Song, J; Zhou, Y, 2020) |
| "A rat model of myocardial ischemia was established via isoproterenol induction." | 3.91 | Compound danshen dripping pills normalize a reprogrammed metabolism of myocardial ischemia rats to interpret its time-dependent efficacy in clinic trials: a metabolomic study. ( Aa, JY; Aa, N; Cao, B; Chu, Y; Guo, JH; Ma, XH; Sun, H; Sun, RB; Wang, GJ; Yang, ZJ; Zhou, SP, 2019) |
| " This study evaluated whether LCZ696 affects left ventricular hypertrophy, fibrosis, and hemodynamics in isoproterenol (ISO)-treated rats compared with valsartan alone." | 3.91 | Effect of LCZ696, a dual angiotensin receptor neprilysin inhibitor, on isoproterenol-induced cardiac hypertrophy, fibrosis, and hemodynamic change in rats. ( Akagi, S; Ito, H; Kondo, M; Miura, D; Miyoshi, T; Nakamura, K; Ohno, Y; Saito, Y; Yoshida, M, 2019) |
| " The investigation was conducted to evaluate the cardioprotective efficacy of RPG in rats having acute myocardial infarction (MI) induced by isoproterenol (ISO)." | 3.91 | Cardioprotective Effect of Rhapontigenin in Isoproterenol-Induced Myocardial Infarction in a Rat Model. ( Fan, Y, 2019) |
| " To assess the effects of phosphodiesterase type 3 and phosphodiesterase type 5 inhibitors on cardiac function and left ventricular myocardial fibrosis in catecholamine-induced myocardial injury, sildenafil and pimobendan were administered to male Wistar rats 24 hours after isoproterenol injection." | 3.91 | Contrasting Effects of Inhibition of Phosphodiesterase 3 and 5 on Cardiac Function and Interstitial Fibrosis in Rats With Isoproterenol-Induced Cardiac Dysfunction. ( Nakata, TM; Shimada, K; Suzuki, K; Tanaka, R; Uemura, A, 2019) |
| "To investigate the effect of acupuncture at PC6 on cardiac hypertrophy in isoproterenol (ISO)-treated mice." | 3.91 | Acupuncture at PC6 prevents cardiac hypertrophy in isoproterenol-treated mice. ( Du, Q; Guo, Y; Hou, Y; Yang, F; Zhang, M; Zhu, P, 2019) |
| "The present study aimed to investigate the potential effects of growth differentiation factor 11 (GDF11) on isoproterenol (ISO)‑induced heart failure (HF) and identify the underlying molecular mechanisms." | 3.91 | Growth differentiation factor 11 is involved in isoproterenol‑induced heart failure. ( Hao, Z; Jia, Y; Li, N; Shi, ZF; Tan, H; Zhang, XJ, 2019) |
| "Several researchers studied the protective effect of the N-acetylcysteine (NAC) when it was given before the induction of myocardial infarction (MI)." | 3.88 | Protective Role of N-Acetylcysteine on Isoprenaline-Induced Myocardial Injury: Histological, Immunohistochemical and Morphometric Study. ( Abdalla, IL; Kaooh, S; Mohamed, EA; Sadik, AOE; Zaki, SM, 2018) |
| " Myocardial infarction was induced in Wistar rats via isoproterenol injection in a dose of (85 mg/kg, subcutaneously, twice at an interval of 24 h)." | 3.88 | Novel Mesenchymal Stem Cell Strategy in Alleviating Toll-Like Receptor-4, p53 and Nrf2 Signaling in Isoproterenol-Induced Myocardial Infarction in Rat Model. ( Abdel-Megeed, RM; Kadry, MO, 2018) |
| "On the basis of preliminary studies and references of relevant literature about Sheng-Mai-San for myocardial ischemia, we chose three representative components (ginsenoside Rb1 (G), ruscogenin (R) and schisandrin (S)) for the optimization design studies." | 3.88 | A Strategy for Optimizing the Combination of Active Components Based on Chinese Medicinal Formula Sheng-Mai-San for Myocardial Ischemia. ( Chu, C; Fan, XX; Kou, JP; Li, F; Yu, BY; Zhang, Y, 2018) |
| " In this study, a simple blood microdialysis sampling system in freely-moving rats was established for simultaneous study of PK and PD of Shengmai injection (SMI) effect on inducing real-time nitric oxide (NO) release on isoproterenol (ISO) induced myocardial ischemia rats." | 3.88 | A simple blood microdialysis in freely-moving rats for pharmacokinetic-pharmacodynamic modeling study of Shengmai injection with simultaneous determination of drug concentrations and efficacy levels in dialysate. ( Ding, B; Huang, X; Jiang, N; Li, M; Liu, G; Lv, X; Ruan, YE; Shao, Q; Zhan, S, 2018) |
| "To investigate the effects and mechanisms of catalpol on cardiac function in rats with isoproterenol (ISO)-induced myocardial infarction (MI)." | 3.88 | Catalpol pretreatment attenuates cardiac dysfunction following myocardial infarction in rats. ( Bi, F; Sun, Q; Xu, Y, 2018) |
| "Isoproterenol is used widely for inducing heart failure in mice." | 3.88 | Isoproterenol-Induced Heart Failure Mouse Model Using Osmotic Pump Implantation. ( Chang, SC; Rau, CD; Ren, S; Wang, JJ, 2018) |
| "In this study, we applied different sizes of gold nanoparticles (Au-NPs) to isoproterenol (ISO)-induced hyperthyroid heart disease rats (HHD rats)." | 3.88 | Size dependent effects of Gold Nanoparticles in ISO-induced Hyperthyroid Rats. ( Ma, A; Ni, Y; Ning, F; Shang, L; Xue, Y; Zhang, J, 2018) |
| "To investigate the effect of dimethyl fumarate (DMF) on Toll-like receptor (TLR) signalling pathway in isoproterenol (ISO)-induced cardiac hypertrophy in rats." | 3.88 | Dimethyl fumarate interferes with MyD88-dependent toll-like receptor signalling pathway in isoproterenol-induced cardiac hypertrophy model. ( Ahmed, AA; Ahmed, AAE; El Morsy, EM; Nofal, S, 2018) |
| "In order to determine the role of the adrenergic system in bupivacaine-induced cardiotoxicity, a series of experiments were performed." | 3.88 | Beta-adrenergic activation induces cardiac collapse by aggravating cardiomyocyte contractile dysfunction in bupivacaine intoxication. ( Chen, Y; Cheng, Y; Chu, L; Duan, R; Li, H; Li, J; Xia, D; Yuan, J; Zhang, J; Zhang, Y; Zhao, S; Zhao, X, 2018) |
| "The effects of diazoxide on cardiac hypertrophy and miR-132 expression were characterized in adult rats and in cardiomyocytes." | 3.88 | Protective Action of Diazoxide on Isoproterenol-Induced Hypertrophy Is Mediated by Reduction in MicroRNA-132 Expression. ( Carrillo, ED; García, MC; Hernández, A; Narasimhan, G; Sánchez, JA, 2018) |
| "To evaluate the effect of oltipraz (OPZ) on isoproterenol-induced heart failure (HF) and heart function." | 3.88 | Oltipraz attenuates the progression of heart failure in rats through inhibiting oxidative stress and inflammatory response. ( Guo, M; Hao, MH; Ma, XY; Sun, WP; Tang, Y; Zhu, HY, 2018) |
| "The present study investigated the protective effect of diethylcarbamazine in inhibiting nuclear factor (NF)-κB activation in isoproterenol‑induced acute myocardial infarction (AMI) rats through the poly ADP ribose polymerase (PARP) pathway." | 3.85 | Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway. ( Jia, G; Liu, X; Zao, M, 2017) |
| ", family Arecaceae) on isoproterenol-induced myocardial infarction (MI) in rats." | 3.85 | Cardiopreventive effect of ethanolic extract of Date Palm Pollen against isoproterenol induced myocardial infarction in rats through the inhibition of the angiotensin-converting enzyme. ( Abid, L; Ayadi, F; Belbahri, L; Ben Amar, R; Ben Mefteh, F; Daoud, A; ElFeki, A; Gharsallah, N; Jmal, S; Kadri, A; Mnafgui, K; Rateb, ME; Turki, M, 2017) |
| "The present study was designed to evaluate the cardioprotective effects of nesfatin-1, a novel peptide with anorexigenic properties, in rats with isoproterenol (ISO)-induced myocardial infarction (MI), and to further investigate the role of Akt/GSK-3β signaling pathway in the protective effect of nesfatin-1." | 3.85 | Cardioprotective effect of nesfatin-1 against isoproterenol-induced myocardial infarction in rats: Role of the Akt/GSK-3β pathway. ( Adiguzel, D; Barutcigil, A; Celik-Ozenci, C; Dalaklioglu, S; Kuscu, N; Ozdem, S; Tasatargil, A, 2017) |
| " macroptera peel and pulp against isoproterenol (ISO)-induced myocardial infarction (MI) in rats." | 3.85 | Protective effects of ethanolic peel and pulp extracts of Citrus macroptera fruit against isoproterenol-induced myocardial infarction in rats. ( Afroz, R; Das, S; Gan, SH; Hossain, MS; Hossen, MS; Ibrahim Khalil, M; Islam, MA; Paul, S; Saha, M; Tanvir, EM, 2017) |
| " The present study was intended to appraise the nutraceutical inherent of HPLC standardized Spinacia oleracea methanolic leaf extract (SoLE) in isoproterenol (ISO) induced male albino Wistar rats via activation of pro-inflammatory signaling pathway that drives myocardial necrosis." | 3.85 | Nutraceutical inherent of Spinacia oleracea Linn. methanolic leaf extract ameliorates isoproterenol induced myocardial necrosis in male albino Wistar rats via mitigating inflammation. ( Jolapuram, U; Kodidhela, LD; Vutharadhi, S, 2017) |
| "Male Sprague Dawley rats were given isoproterenol 5 mg/kg once a day for 7 days to establish heart failure model by subcutaneous injection." | 3.85 | Protective effects of low-dose rosuvastatin on isoproterenol-induced chronic heart failure in rats by regulation of DDAH-ADMA-NO pathway. ( Ma, P; Wang, Y; Xiong, A; Xu, Q; Xu, Y; Zhou, R, 2017) |
| " Here, we investigated the effect of CaMKII inhibition in isoproterenol (ISO)-induced arrhythmias in hypertrophic mice." | 3.85 | CaMKII inhibition reduces isoproterenol-induced ischemia and arrhythmias in hypertrophic mice. ( Cheng, J; Feng, Y; Wang, Y; Wei, B, 2017) |
| " The current study evaluated the consequence of AP in isoproterenol (ISO)-induced oxidative stress and myocardial infarction during β-adrenergic receptor stimulus in rats by persistent hemodynamic, biochemical and histopathological changes." | 3.83 | Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System. ( Buwa, CC; Goyal, SN; Mahajan, UB; Patil, CR, 2016) |
| "This study aimed to evaluate the antithrombotic, anti-inflammatory and anti-cardiac remodeling properties of eugenol in isoproterenol-induced myocardial infarction in rats." | 3.83 | Anti-inflammatory, Antithrombotic and Cardiac Remodeling Preventive Effects of Eugenol in Isoproterenol-Induced Myocardial Infarction in Wistar Rat. ( Allouche, N; Derbali, F; Ellefi, H; Gammoudi, A; Gharsallah, N; Hajji, R; Kadri, A; Khabbabi, G; Mnafgui, K, 2016) |
| "This study was aimed to investigate the possible inhibitory effects of aliskiren (ALS) and/or carvedilol (CAV) on CaMKIIδ isoforms expression in experimental cardiac hypertrophy." | 3.83 | Effect of aliskiren and carvedilol on expression of Ca(2+)/calmodulin-dependent protein kinase II δ-subunit isoforms in cardiac hypertrophy rat model. ( Abdel Baky, NA; Al-Mohanna, F; Bin-Dayel, AF; Fadda, LM; Mohammad, RA, 2016) |
| "Isoproterenol infusions generated significant cardiac fibrosis (p < 0." | 3.83 | Paricalcitol Attenuates Cardiac Fibrosis and Expression of Endothelial Cell Transition Markers in Isoproterenol-Induced Cardiomyopathic Rats. ( Cheng, PW; Hsiao, M; Lai, CC; Liou, JC; Liu, CP; Lu, PJ; Lu, WH; Sun, GC; Tseng, CJ, 2016) |
| " Isoproterenol (ISO) was used to induce cardiac hypertrophy in Wistar rats." | 3.83 | Suppression of calcium‑sensing receptor ameliorates cardiac hypertrophy through inhibition of autophagy. ( Li, H; Lin, Y; Liu, L; Shi, S; Tian, Y; Wang, C; Wang, L; Xi, Y; Xu, C; Zhang, W; Zhao, Y, 2016) |
| " In a cardiac specific transgenic mouse model, it was observed that overexpression of hHole specifically in heart attenuated cardiac hypertrophy and fibrosis induced by isoproterenol (ISO), with blunted transcriptions of ERK1/2, total ERK1/2 proteins and phosphorylated ERK1/2 (p-ERK1/2) levels." | 3.83 | Cardiac Specific Overexpression of hHole Attenuates Isoproterenol-Induced Hypertrophic Remodeling through Inhibition of Extracellular Signal-Regulated Kinases (ERKs) Signalling. ( Cao, L; Chen, F; Dai, G; Deng, Y; Fan, X; Jiang, Z; Li, Y; Liu, X; Luo, S; Mo, X; Peng, X; Shi, Y; Wan, Y; Wang, X; Wang, Y; Wu, X; Xu, W; Ye, X; Yuan, W; Zeng, Q; Zhang, S; Zhou, J; Zhu, X, 2016) |
| " We used normal (Ctrl) and hyperthyroid rat (HT; reduced phospholamban by ∼80%) myocytes treated with thapsigargin or isoproterenol (ISO)." | 3.83 | Role of SERCA and the sarcoplasmic reticulum calcium content on calcium waves propagation in rat ventricular myocytes. ( Altamirano, J; Balderas-Villalobos, J; García, N; Gómez-Víquez, NL; Montalvo-Parra, D; Pérez-Treviño, P; Salazar-Cantú, A, 2016) |
| "We aimed to understand the genetic control of cardiac remodeling using an isoproterenol-induced heart failure model in mice, which allowed control of confounding factors in an experimental setting." | 3.83 | Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. ( Avetisyan, R; Gong, KW; Lusis, AJ; Rau, C; Ren, S; Romay, MC; Stolin, G; Wang, JJ; Wang, Y, 2016) |
| " Consistently, TβRIII expression was substantially increased in transverse aortic constriction (TAC)- and isoproterenol-induced mouse cardiac hypertrophy in vivo and in isoproterenol-induced cardiomyocyte hypertrophy in vitro." | 3.83 | Type III Transforming Growth Factor-β Receptor Drives Cardiac Hypertrophy Through β-Arrestin2-Dependent Activation of Calmodulin-Dependent Protein Kinase II. ( Chu, W; Ding, XQ; Dong, CJ; Ji, Y; Li, H; Li, YC; Li, YY; Liu, MT; Lou, J; Song, SY; Sun, F; Yu, CJ; Zhang, LL; Zhang, ZR; Zhao, D, 2016) |
| " β-AR overstimulation with associated cardiac hypertrophy and increased vasoconstrictor response to phenylephrine in aorta were modeled in rats by 7-day isoproterenol treatment." | 3.83 | Spironolactone Prevents Endothelial Nitric Oxide Synthase Uncoupling and Vascular Dysfunction Induced by β-Adrenergic Overstimulation: Role of Perivascular Adipose Tissue. ( Alonso, MJ; Clerici, SP; Davel, AP; Jaffe, IZ; Palacios, R; Rossoni, LV; Vassallo, DV; Victorio, JA, 2016) |
| "Intent of the present study has been made to appraise the cardioprotective effect of chlorogenic acid (CGA) on isoproterenol (ISO) induced myocardial infarction (MI) in male albino Wistar rats." | 3.83 | Chlorogenic acid a dietary polyphenol attenuates isoproterenol induced myocardial oxidative stress in rat myocardium: An in vivo study. ( Akila, P; Vennila, L, 2016) |
| "The aim of the present study was to confirm the effect of Tanshinone IIA (TAN) on the prevention of AF in chronic heart failure (CHF), and to elucidate the underlying electrophysiological mechanisms for the antiarrhythmic effects of TAN at the level of the atrium in an experimental model of CHF." | 3.83 | Reduction of atrial fibrillation by Tanshinone IIA in chronic heart failure. ( Cheng, D; He, Z; Sun, C; Xu, Y, 2016) |
| "The effects of benidipine on oxidative stress and myocardial apoptosis were assessed in isoproterenol (ISO)-induced myocardial infarction (MI) in wistar rats." | 3.81 | Benidipine prevents oxidative stress, inflammatory changes and apoptosis related myofibril damage in isoproterenol-induced myocardial infarction in rats. ( Akhtar, M; Akhtar, MS; Ali, J; Ansari, SH; Haque, SE; Hassan, MQ; Najmi, AK, 2015) |
| " Therefore because oxidative stress plays a significant role in the pathophysiology of myocardial infarction (MI), the aim of our study was to investigate whether hydrogen-rich saline has cardioprotective effects against isoproterenol-induced MI in rats." | 3.81 | Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats. ( Han, JJ; Jing, L; Qin, SC; Sun, XJ; Wang, Y; Zhao, B; Zhao, XM, 2015) |
| "Combined effects of vincristine and quercetin in the regulation of isoproterenol (ISO)-induced cardiac necrosis have been evaluated in rats." | 3.81 | Combined Effects of Vincristine and Quercetin in Reducing Isoproterenol-Induced Cardiac Necrosis in Rats. ( Kar, A; Panda, S, 2015) |
| "This study was aimed to evaluate the preventive role of phytic acid on lysosomal enzymes in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats." | 3.81 | Preventive effect of phytic acid on lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats. ( Brindha, E; Rajasekapandiyan, M, 2015) |
| "In this study, we evaluated ET effects on isoproterenol (ISO)-induced cardiac hypertrophy in female mice." | 3.81 | Nitric oxide synthase inhibition abolishes exercise-mediated protection against isoproterenol-induced cardiac hypertrophy in female mice. ( Li, J; Liu, J; Lu, P; Qi, Z; Ren, J; Tian, W; Yang, L; Zhu, M, 2015) |
| " alata (LPva) in isoproterenol (ISO)-induced myocardial infarction (MI) in rats." | 3.81 | Protective effects of Labisia pumila var. alata on biochemical and histopathological alterations of cardiac muscle cells in isoproterenol-induced myocardial infarction rats. ( Amran, AZ; Dianita, R; Jalil, J; Jantan, I, 2015) |
| "The present study was designed to evaluate the cardioprotective potential of edaravone on oxidative stress, anti-apoptotic, anti-inflammatory and ultrastructure findings in isoproterenol (ISO) induced myocardial infarction (MI) in rats." | 3.81 | Edaravone protects rats against oxidative stress and apoptosis in experimentally induced myocardial infarction: Biochemical and ultrastructural evidence. ( Akhtar, M; Akhtar, MS; Ali, J; Haque, SE; Hassan, MQ; Najmi, AK, 2015) |
| "Recent evidence has shown that, in heart failure (HF), clinically relevant concentrations of angiotensin-(1-7) [Ang-(1-7)] counteracts angiotensin II induced cardiac depression and produces positive inotropic effects in both left ventricle (LV) and myocytes." | 3.81 | Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal versus heart failure. ( Cheng, CP; Cheng, HJ; Ferrario, CM; Li, T; Zhou, P, 2015) |
| " The present study was designed to investigate the effect of pretreatment with SIM on isoproterenol (ISO)-induced cardiac hypertrophy in rats." | 3.81 | Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway. ( Al-Manee, RZ; Al-Oteibi, MM; Al-Rasheed, NM; Al-Shareef, SA; Hasan, IH; Mahmoud, AM; Mohamad, RA, 2015) |
| "This study aimed to explore the effects of puerarin on autophagy in cardiac hypertrophy." | 3.81 | Puerarin prevents cardiac hypertrophy induced by pressure overload through activation of autophagy. ( Chen, M; Huang, Z; Li, Y; Liu, B; Liu, P; Luo, C; Ou, C; Wu, Z; Zhang, J, 2015) |
| "Although it is well known that isoproterenol (ISO) causes myocardial hypertrophy and myocardial fibrosis in rats, it has remained elusive whether heat shock factor 1 (HSF1) has a role in this process." | 3.81 | Roles of heat shock factor 1 in isoproterenol‑induced myocardial fibrosis in mice. ( Fang, L; Xie, Y; Zhang, B; Zhang, L, 2015) |
| "In this study, we investigated the cardioprotective effect of one purified polysaccharide (SMP1) from Salvia miltiorrhiza on isoproterenol (ISO)-induced myocardial infarction (MI) in rats." | 3.81 | Protective effect of a polysaccharide from Salvia miltiorrhiza on isoproterenol (ISO)-induced myocardial injury in rats. ( Geng, ZH; Huang, L; Song, MB; Song, YM, 2015) |
| "To assess the impact of transfection with recombinant adenovirus vector-mediated Klotho gene on myocardial remodeling in a rat model of heart failure (HF) by intraperitoneal injection of isoproterenol." | 3.81 | [Impact of transfection with recombinant adenovirus vector-mediated Klotho gene on myocardial remodeling in a rat model of heart failure]. ( Chen, W; Gan, S; Jia, Z; Liu, Q; Wei, L; Yang, J; Yang, X; Zhang, L; Zhu, Z, 2015) |
| "The aim of the present study was to investigate the cardioprotective effects of Timosaponin B II (TB), a main bioactive constituent from Anemarrhenae asphodeloides Bge, on an isoproterenol (ISO)-induced myocardial infarction model in rats and explore its underlying mechanisms." | 3.81 | Cardioprotective effects of timosaponin B II from Anemarrhenae asphodeloides Bge on isoproterenol-induced myocardial infarction in rats. ( Chen, JJ; Deng, XY; Fu, Q; Li, HY; Ma, SP; Ma, ZQ, 2015) |
| " Electrocardiography on isoproterenol challenged mice showed that both models developed arrhythmias and died within 24 hours, while wild-type mice were free of pathology." | 3.81 | Selective Connexin43 Inhibition Prevents Isoproterenol-Induced Arrhythmias and Lethality in Muscular Dystrophy Mice. ( Contreras, JE; Fraidenraich, D; Gonzalez, JP; Ramachandran, J; Xie, LH, 2015) |
| "Isoproterenol (5 mg·kg(-1)·d(-1)) was used to establish the cardiac fibrosis model in rats, which were administered RLX." | 3.81 | Relaxin inhibits cardiac fibrosis and endothelial-mesenchymal transition via the Notch pathway. ( Cai, JJ; Chen, LZ; Chen, X; Gao, Z; Gong, YS; Huang, WJ; Wang, LX; Zhang, HQ; Zhou, H; Zhou, X, 2015) |
| " Myocardial infarction was induced by isoproterenol (ISP) (65 mg/kg) and confirmed by biochemical, electrophysiological and histopathological methods." | 3.81 | Anti-platelet effects of nimesulide in isoproterenol-induced myocardial ischaemia and infarction in rabbits. ( Ahmed, S; Dima, L; Gul, S; Moga, M; Ze Jaafar, H; Zia-Ul-Haq, M, 2015) |
| " The current study investigated the effect of cardamom on hemodynamic, biochemical, histopathological and ultrastructural changes in isoproterenol (ISO)-induced myocardial infarction." | 3.81 | Protective Effects of Cardamom in Isoproterenol-Induced Myocardial Infarction in Rats. ( Agrawal, YO; Arya, DS; Goyal, SN; Kumari, S; Mahajan, UB; Ojha, S; Patil, CR; Sharma, C, 2015) |
| " This study evaluated the protective effect of XKS against isoproterenol (ISO)-induced myocardial infarction (MI)." | 3.80 | Metabolic pathways involved in Xin-Ke-Shu protecting against myocardial infarction in rats using ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. ( Cai, DY; Chang, X; Cheng, WH; Ding, G; Jia, HM; Liu, YT; Zhang, HW; Zhao, X; Zou, ZM, 2014) |
| "The present study was designed to evaluate the cardioprotective potential of water extract of rhizomes of Acorus gramineus (AGR) against isoproterenol (ISO)-induced myocardial infarction." | 3.80 | Cardioprotective effect of rhizomes of Acorus gramineus against isoproterenol-induced cardiac damage in pigs. ( Antonisamy, P; Bae, H; Chung, HS; Kim, JH; Lee, SR, 2014) |
| "We have previously shown that pentoxifylline (PTX) protects from vascular complications associated with insulin resistance (IR)." | 3.80 | Pentoxifylline alleviates cardiac ischemia and dysfunction following experimental angina in insulin resistance. ( Azhar, A; El-Bassossy, HM, 2014) |
| "Our data suggest that tamoxifen produces beneficial effects on cardiac hypertrophy and hence may be considered as a preventive measure for cardiac hypertrophy." | 3.80 | Beneficial role of tamoxifen in experimentally induced cardiac hypertrophy. ( Desai, VJ; Patel, BM, 2014) |
| "The physiological mechanisms involved in isoproterenol (ISO)-induced chronic heart failure (CHF) are not fully understood." | 3.80 | Changes in cardiac aldosterone and its synthase in rats with chronic heart failure: an intervention study of long-term treatment with recombinant human brain natriuretic peptide. ( Chen, LL; Hong, HS; Li, YH; Lin, XH; Zhu, XQ, 2014) |
| "Introduction of isoproterenol (an agonist of beta-adrenoreceptors) to rats is one of the widespread experimental models of cardiac failure." | 3.80 | [Complex study of the rat heart at isoproterenol damage]. ( Abramov, VS; Ermishkin, VV; Gramovich, VV; Kapel'ko, VI; Lakomkin, SV; Lakomkin, VL; Lukoshkova, EV; Shirinskiĭ, VP; Undrovinas, NA; Veselova, SP; Vyborov, ON; Zhdanov, VS, 2014) |
| "Scutellarin (SCU) is the major active component of breviscapine and has been reported to be capable of decreasing myocardial fibrosis." | 3.80 | Anti-fibrosis effect of scutellarin via inhibition of endothelial-mesenchymal transition on isoprenaline-induced myocardial fibrosis in rats. ( Cai, J; Chen, L; Chen, X; Huang, W; Zhang, H; Zheng, G; Zhou, H; Zhou, X, 2014) |
| "The present study was designed to investigate whether oxymatrine could attenuate isoproterenol-induced heart failure via regulation of asymmetric dimethylarginine (ADMA) metabolism in rats." | 3.80 | Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in rats. ( Dai, G; Liu, J; Liu, YK; Wang, X; Wang, Y; Xu, Q; Xu, X; Zhang, J; Zhang, W, 2014) |
| "To establish a model of cardiac fibrosis induced by isoproterenol (ISO), the non-selective β adrenoceptor agonist, injected subcutaneously for 7 days in rats, and to observe changes of transcription factor NF-κB in the model." | 3.80 | [Activation of transcription factor NF-κB in a rat model of cardiac fibrosis induced by β-adrenoceptor stimulation]. ( Li, ZJ; Lu, HY; Tian, AJ; Yang, CZ; Yang, QX; Yin, Q; Zhang, YY; Zheng, XH; Zheng, XP, 2014) |
| " miR-22-null hearts blunted cardiac hypertrophy and cardiac remodeling in response to 2 independent stressors: isoproterenol infusion and an activated calcineurin transgene." | 3.79 | MicroRNA-22 regulates cardiac hypertrophy and remodeling in response to stress. ( Chen, J; Hu, X; Huang, ZP; Kataoka, M; Seok, HY; Wang, DZ; Zhang, Z, 2013) |
| "The present study aimed at using a proteomics based approach to: a) analyze and contrast the proteome of the healthy and isoproterenol induced hypertrophied hearts and b) identify potential biomarkers for diagnosis of cardiac hypertrophy." | 3.79 | A proteomic view of isoproterenol induced cardiac hypertrophy: prohibitin identified as a potential biomarker in rats. ( Banerjee, SK; Bhadra, MP; Chowdhury, D; Khatua, TN; Saxena, P; Tangutur, AD, 2013) |
| "This study was aimed to evaluate the preventive effect of diosgenin and exercise on tissue antioxidant status in isoproterenol-induced myocardial infarction (MI) in male Wistar rats." | 3.79 | Preconditioning with diosgenin and treadmill exercise preserves the cardiac toxicity of isoproterenol in rats. ( Mohammadi, M; Rashidi, B; Salimeh, A, 2013) |
| "In PKA inhibitor peptide transgenic mice, chronic isoproterenol failed to induce cardiac hypertrophy, fibrosis, and myocyte apoptosis, and decreased cardiac function." | 3.79 | Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling. ( Ai, X; Chen, X; Fu, Q; Gao, E; Gao, H; Ge, XJ; Jin, J; Kunapuli, SP; Li, Y; Makarewich, C; Szeto, C; Tang, A; Tang, M; Wang, F; Wang, J; Xiang, KY; Zeng, C; Zhang, X; Zhou, L, 2013) |
| "To elucidate the expression and identify the functional changes of 2 pore domain potassium channel TREK-1 during cardiac hypertrophy in rats, left ventricular hypertrophy was induced by subcutaneous injection with isoproterenol." | 3.79 | An increased TREK-1-like potassium current in ventricular myocytes during rat cardiac hypertrophy. ( Feng, N; Li, P; Peng, Y; Wang, L; Wang, W; Wang, X; Yuan, H; Zhang, M, 2013) |
| " In the present study, we evaluated the effects of metformin on cardiac function, hemodynamic parameters, and histopathological changes in isoproterenol-induced myocardial infarction (MI)." | 3.78 | Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats. ( Garjani, A; Khorrami, A; Maleki-Dizaji, N; Soraya, H, 2012) |
| "To assess the protective effects of lycopene on electrocardiographic, hemodynamic, biochemical and apoptotic changes in isoproterenol induced myocardial infarction." | 3.78 | Tomato lycopene attenuates myocardial infarction induced by isoproterenol: electrocardiographic, biochemical and anti-apoptotic study. ( Aman, U; Balaraman, R; Vaibhav, P, 2012) |
| " The present study was evaluated to investigate whether pyruvate attenuates the development of cardiotoxicity in isoproterenol (ISO)-induced myocardial infarction by assessing hemodynamic, biochemical and histopathological parameters." | 3.78 | Pyruvate attenuates cardiac dysfunction and oxidative stress in isoproterenol-induced cardiotoxicity. ( Arya, DS; Goyal, S; Kumari, S; Ojha, S, 2012) |
| "The aim of this investigation was to evaluate the preventive role of morin, a flavonoid, on cardiac marker enzymes such as aspartate transaminase, lactate dehydrogenase, creatine kinase and creatine kinase-MB, membrane-bound enzymes such as sodium potassium-dependent adenosine triphosphatase, calcium-dependent adenosine triphosphatase and magnesium-dependent adenosine triphosphatase, and glycoproteins such as hexose, hexosamine, fucose and sialic acid in isoproterenol (ISO)-induced myocardial infarction (MI) in rats." | 3.78 | Pretreatment with morin, a flavonoid, ameliorates adenosine triphosphatases and glycoproteins in isoproterenol-induced myocardial infarction in rats. ( Al-Numair, KS; Alsaif, MA; Chandramohan, G, 2012) |
| "Following induction of acute myocardial infarction in rats by adminstration of isoproterenol, hemodynamic and electrocardiographic parameters were monitored and recorded continuously, cardiac enzymes and parameters of oxidative stress were measured, and histopathological examination of heart tissue was performed." | 3.78 | Cardioprotective effect of water and ethanol extract of Salvia miltiorrhiza in an experimental model of myocardial infarction. ( Chao, RB; Du, JR; He, LF; Li, YJ; Shen, Y; Zhou, R, 2012) |
| "The present investigation was to evaluate the antioxidant, biochemical profile and histological studies of qualitatively standardized ethanolic extract of Terminalia pallida fruits (TpFE) against isoproterenol-induced myocardial infarction in rats." | 3.78 | Cardioprotective effect of HPLC standardized ethanolic extract of Terminalia pallida fruits against isoproterenol-induced myocardial infarction in albino rats. ( Abdul Kareem, M; Lakshmi Devi, K; Rasool, SN; Saayi Krushna, G; Shaik, AH; Vikram Kumar Reddy, A, 2012) |
| "Castration significantly increased cardiomyocyte apoptosis and fibrosis that was normally induced by isoproterenol (P<0." | 3.78 | Testosterone improves cardiac function and alters angiotensin II receptors in isoproterenol-induced heart failure. ( Cao, JX; Fu, L; Han, Y; Kang, NN; Sun, JF; Xu, J; Zheng, M, 2012) |
| "Although spironolactone and telmisartan are reported to reduce the risk of morbidity and death, direct studies on their effects on isoproterenol-induced cardiac hypertrophy are scanty." | 3.78 | Beneficial role of spironolactone, telmisartan and their combination on isoproterenol-induced cardiac hypertrophy. ( Goyal, BR; Mehta, AA, 2012) |
| "Cardiac hypertrophy was induced in wild-type and IL-10 knockout mice by isoproterenol (ISO) infusion." | 3.78 | Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB. ( Barefield, D; Ghosh, AK; Gupta, R; Hoxha, E; Kishore, R; Krishnamurthy, P; Lambers, E; Mackie, A; Qin, G; Ramirez, V; Sadayappan, S; Singh, N; Thal, M; Verma, SK, 2012) |
| "Ranolazine (RAN) was reported to be effective and safe in converting atrial fibrillation (AF) to sinus rhythm by administration of a single dose ('pill in the pocket') to patients with structural heart disease." | 3.78 | Further insights into the underlying electrophysiological mechanisms for reduction of atrial fibrillation by ranolazine in an experimental model of chronic heart failure. ( Clauß, C; Eckardt, L; Frommeyer, G; Kaese, S; Milberg, P; Pott, C; Schmidt, M; Stypmann, J, 2012) |
| "The protective effect of aspartate and glutamate in isoproterenol induced myocardial infarction (MI) was investigated in experimental animals." | 3.77 | Aspartate and glutamate prevents isoproterenol-induced cardiac toxicity by alleviating oxidative stress in rats. ( Babu, PV; Shyamaladevi, CS; Sivakumar, R, 2011) |
| "The present study evaluated the protective potential of aqueous extract of Oxalis corniculata (OCE) against isoproterenol (ISO) induced myocardial infarction in rats." | 3.77 | Cardioprotective effects of aqueous extract of Oxalis corniculata in experimental myocardial infarction. ( Abhilash, PA; Lijo Cherian, O; Nampoothiri, SV; Nisha, P; Prathapan, A; Raghu, KG; Sunitha, TK, 2011) |
| " were screened with mice model of acute myocardial hypoxia induced by isoproterenol and pituitrin, eight compounds, i." | 3.77 | Anti-hypoxia activity and related components of Rhodobryum giganteum par. ( Cai, Y; Chen, R; Lu, X; Lu, Y; Wei, Q, 2011) |
| "The present study demonstrated prophylactic and therapeutic potential of Terminalia arjuna bark extract in isoproterenol (ISO)-induced chronic heart failure (CHF)." | 3.77 | Mechanistic clues in the cardioprotective effect of Terminalia arjuna bark extract in isoproterenol-induced chronic heart failure in rats. ( Agarwal, S; Babbar, R; Fahim, M; Kotwani, A; Parveen, A, 2011) |
| "To develop a rat model of myocardial infarction induced by isoproterenol (ISO)." | 3.77 | Time-dependent responses of rat troponin I and cardiac injury following isoproterenol administration. ( Hasić, S; Jadrić, R; Kiseljaković, E; Mornjaković, Z; Valjevac, A; Winterhalter-Jadrić, M, 2011) |
| "To compare the potency and ureteral selectivity of the selective β(2)/β(3)-adrenoceptor agonist KUL-7211 with those of the nonselective β-adrenoceptor agonist isoproterenol, selective β(2)-adrenoceptor agonist terbutaline, and selective β(3)-adrenoceptor agonist CL-316243, we performed the study using an isolated porcine ureter and a porcine model of acute unilateral ureteral obstruction." | 3.77 | Ureteral selectivity of intravenous β-adrenoceptor agonists in pig model of acute ureteral obstruction: comparison of KUL-7211, a selective β2/β3 agonist, with isoproterenol, terbutaline, and CL-316243. ( Kojima, M; Tomiyama, Y; Wanajo, I; Yamazaki, Y, 2011) |
| "Heart failure was induced by isoproterenol in male Sprague-Dawley rats." | 3.77 | Icariin attenuates cardiac remodelling through down-regulating myocardial apoptosis and matrix metalloproteinase activity in rats with congestive heart failure. ( Cai, H; Cao, SP; Gu, N; Qian, CF; Song, YH; Zhao, ZM, 2011) |
| " After the pretreatment period, isoproterenol (100mg/kg) was injected to rats at an interval of 24h for two days to induce myocardial infarction." | 3.76 | Pretreatment with a combination of quercetin and alpha-tocopherol ameliorates adenosine triphosphatases and lysosomal enzymes in myocardial infarcted rats. ( Prince, PS; Punithavathi, VR, 2010) |
| " Isolated myocytes from overexpressing lines showed increased Ca(2+) transients and arrhythmias in response to endothelin-1 stimulation." | 3.76 | The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. ( Bers, DM; Blatter, LA; Bodi, I; DeSantiago, J; Domeier, TL; Lorenz, JN; Maillet, M; Mikoshiba, K; Molkentin, JD; Nakayama, H, 2010) |
| "The present study was designed to investigate the cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats by studying myocyte injury markers, antioxidant defense system, serum and heart lipid profile, inflammatory markers, electrocardiographic and histopathological changes." | 3.76 | Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: A biochemical, electrocardiographic and histoarchitectural evaluation. ( Balaraman, R; Patel, V; Upaganlawar, A; Zalawadia, R, 2010) |
| "The aim of this study was to determine if CPU228, a derivative of dofetilide, is more effective than dofetilide in attenuating isoproterenol-induced heart failure by recovering downregulated FK506 binding protein (FKBP12." | 3.76 | CPU228, a derivative of dofetilide, relieves cardiac dysfunction by normalizing FKBP12.6, NADPH oxidase and protein kinase C epsilon in the myocardium. ( Dai, DZ; Dai, Y; Hamed, KH; Hu, C; Yu, F, 2010) |
| "The present study was undertaken to evaluate the preventive role of naringin on mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats." | 3.75 | Naringin ameliorates mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol-induced myocardial infarction in Wistar rats. ( Prince, PS; Rajadurai, M, 2009) |
| " We found that, in the left ventricle, Gal-3 1) enhanced macrophage and mast cell infiltration, increased cardiac interstitial and perivascular fibrosis, and causes cardiac hypertrophy; 2) increased TGF-beta expression and Smad3 phosphorylation; and 3) decreased negative change in pressure over time response to isoproterenol challenge, ratio of early left ventricular filling phase to atrial contraction phase, and left ventricular ejection fraction." | 3.75 | N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin. ( André, S; Carretero, OA; D'Ambrosio, M; Gabius, HJ; Liao, TD; Liu, YH; Peng, H; Rhaleb, NE; Sharma, U, 2009) |
| " This study was designed to evaluate the protective effect of gallic acid on cardiac marker enzymes, troponin-T, LDH-isoenzyme pattern, lipid peroxidation products and antioxidant status in isoproterenol (ISO)-induced myocardial infarction in male Wistar rats." | 3.75 | Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats. ( Prince, PS; Priscilla, DH, 2009) |
| "The study aimed to evaluate the protective role of myricetin obtained from Vitis vinifera (Vitaceae) on heart rate, electrocardiographic (ECG) patterns, vascular reactivity to catecholamines, cardiac marker enzymes, antioxidant enzymes together with morphological and histopathological changes in isoproterenol (ISO) induced myocardial infarction (MI) in male Wistar rats." | 3.75 | Cardioprotective potential of myricetin in isoproterenol-induced myocardial infarction in Wistar rats. ( Ballero, M; Kasture, S; Maxia, A; Mohan, M; Tiwari, R, 2009) |
| "Our study demonstrates the contribution of IL-17 to myocardial fibrosis in isoproterenol-induced HF." | 3.75 | IL-17 induces myocardial fibrosis and enhances RANKL/OPG and MMP/TIMP signaling in isoproterenol-induced heart failure. ( Feng, W; Li, W; Li, Y; Liu, W; Wang, F; Yan, W, 2009) |
| "To study the protective effect of Buyanghuanwu Decoction on myocardial ischemia induced by isoproterenol in rats." | 3.75 | [Protective effect of Buyanghuanwu Decoction on myocardial ischemia induced by isoproterenol in rats]. ( Ji, QL; Lin, R; Liu, Y; Yang, YJ; Zhang, H; Zhang, JY, 2009) |
| "We demonstrated that propranolol reduced the incidence of arrhythmias in a rat model of myocardial infarction by coronary artery occlusion." | 3.75 | MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotection. ( Dong, D; Li, B; Li, X; Lu, Y; Pan, Z; Qiao, G; Shan, H; Song, W; Xu, C; Yang, B; Zhang, B; Zhang, F; Zhang, Y, 2009) |
| " The present study has been designed to investigate whether telmisartan treatment attenuates the development of acute myocardial infarction in isoproterenol-treated rats by restoring hemodynamic, biochemical, histopathological and ultrastructural changes." | 3.75 | Myocardial salvaging effect of telmisartan in experimental model of myocardial infarction. ( Arora, S; Arya, DS; Goyal, S; Joshi, S; Kumari, S; Mittal, R; Nag, TC; Ray, R, 2009) |
| "Transgenic (TG) Ca/calmodulin-dependent protein kinase II (CaMKII)delta(C) mice have heart failure and isoproterenol (ISO)-inducible arrhythmias." | 3.75 | Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure. ( Abesser, M; Backs, J; Brown, JH; Grefe, C; Khabbazzadeh, S; Maier, LS; Maier, SK; Neef, S; Neumann, K; Olson, EN; Opiela, MK; Sag, CM; Wadsack, DP, 2009) |
| "To investigate the changes of apelin in plasma and myocardium of model rats and the protective mechanisms of Extracts of Ginkgo biloba leaves (EGb) on myocardial ischemia injury induced by isoproterenol." | 3.75 | [Effects of extracts of Ginkgo biloba leaves on apelin concentration and expressions in plasma and myocardium of rats with myocardial ischemia injury]. ( Huang, JL; Xiong, GZ; Ye, CL; Ye, KH, 2009) |
| "Isoproterenol-induced cardiac hypertrophy in mice has been used in a number of studies to model human cardiac disease." | 3.75 | Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure. ( Errami, M; Galindo, CL; Garner, HR; Kumar, NM; Li, J; McCormick, JF; McIver, LJ; Olson, LD; Pham, TQ; Skinner, MA; Watson, DA, 2009) |
| "A recent clinical study has shown that carvedilol has a significantly more favorable effect than metoprolol on survival rate in patients with heart failure." | 3.74 | Comparison of pharmacodynamics between carvedilol and metoprolol in rats with isoproterenol-induced cardiac hypertrophy: effects of carvedilol enantiomers. ( Asari, K; Hanada, K; Kawana, J; Mita, M; Ogata, H; Saito, M, 2008) |
| " Male SD rats were subcutaneously injected with isoproterenol (ISO) to induce myocardial ischemia." | 3.74 | The myocardial response to adrenomedullin involves increased cAMP generation as well as augmented Akt phosphorylation. ( Cao, CQ; Jin, SJ; Pan, CS; Qi, YF; Tang, CS; Wang, X; Zhang, J; Zhao, J, 2007) |
| "The aim of the present study was performed to determine whether a novel histone deacetylase (HDAC) inhibitor, N-(2-aminophenyl)-4-{[benzyl(2-hydroxyethyl)amino]methyl} benzamide (K-183), prevents a reversible cardiac hypertrophy induced by isoproterenol and improves left ventricular (LV) dysfunction in rats." | 3.74 | Effects of a novel histone deacetylase inhibitor, N-(2-aminophenyl) benzamide, on a reversible hypertrophy induced by isoproterenol in in situ rat hearts. ( Kitagawa, Y; Nakajima-Takenaka, C; Shimizu, J; Takaki, M; Tamura, Y; Taniguchi, S; Uesato, S, 2007) |
| " Potential cerebroprotective vascular effects of CORM-A1 (2 mg/kg ip, 30 min before seizures) were tested 2 days after bicuculline-induced epileptic seizures (late postictal period)." | 3.74 | Cerebroprotective effects of the CO-releasing molecule CORM-A1 against seizure-induced neonatal vascular injury. ( Fedinec, AL; Leffler, CW; Parfenova, H; Tcheranova, D; Zimmermann, A, 2007) |
| " Similarly, adult beta1KOmdx males were more prone to isoproterenol-induced heart failure and death compared with control groups." | 3.74 | Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification. ( Chu, AL; Chun, J; Elsherif, L; Huang, MS; Kaufman, SJ; Li, RY; Mekany, MA; Ross, RS; Shai, SY; Yang, Y, 2008) |
| "Heart failure (HF) may be produced by sustained beta-adrenoceptor stimulation by causing changes in the expression of endothelin-1 (ET-1), the leptin system, calcineurin and sarcoplasmic reticulum Ca2+ ATPase 2a (SERCA2a) underlying cardiac dysfunction." | 3.74 | Protective effect of the endothelin antagonist CPU0213 against isoprenaline-induced heart failure by suppressing abnormal expression of leptin, calcineurin and SERCA2a in rats. ( Dai, DZ; Dai, Y; Ji, H; Tang, XY; Xu, M, 2008) |
| "1 The purpose of this study was to examine the effect of inhibition of the formation of cytochrome P450 metabolites of arachidonic acid with 1-aminobenzotriazole (ABT) on the development of hypertension and end-organ damage in spontaneously hypertensive rats (SHR) chronically treated with nitric oxide synthesis inhibitor L-NAME (SHR-L-NAME)." | 3.73 | Contribution of cytochrome P450 metabolites of arachidonic acid to hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME. ( Benter, IF; Canatan, H; Cojocel, C; Francis, I; Juggi, JS; Yousif, MH, 2005) |
| "To examine the negative regulation role of PTEN in isoproterenol-induced cardiac hypertrophy by testing the expression of PTEN mRNA and protein and to explore the effects of captopril (Cap) on PTEN expression." | 3.73 | [PTEN negatively regulates isoproterenol-induced cardiac hypertrophy and effects of captopril on PTEN expression]. ( Tian, Y; Wang, J; Yu, LJ; Zhou, YZ; Zhu, SJ, 2005) |
| "Gene expression of heparanase, matrix metalloproteinases (MMP)-2 and MMP-9 were examined in ventricles after chronic treatment with isoproterenol (ISO) induced cardiac hypertrophy in rats." | 3.73 | Induction of heparanase gene expression in ventricular myocardium of rats with isoproterenol-induced cardiac hypertrophy. ( Hara, Y; Hashizume, K; Ito, R; Kizaki, K; Mutoh, K; Okada, M; Yoshioka, K, 2005) |
| "Isoproterenol-induced cardiac hypertrophy is associated with increased expression of endothelial nitric oxide synthase in the aorta but without signs of improved endothelial function." | 3.73 | Increased expression of endothelial nitric oxide synthase and caveolin-1 in the aorta of rats with isoproterenol-induced cardiac hypertrophy. ( Fecenkova, A; Gazova, A; Klimas, J; Krenek, P; Kroslakova, M; Kucerova, D; Kyselovic, J; Plandorova, J; Svec, P, 2006) |
| " Cardiac lesions induced by isoproterenol (ISO) are characterized by myocardial necrosis and exudative infiltration." | 3.72 | Effect of D-003 on isoproterenol-induced myocardial necrosis in rats. ( Arruzazabala, ML; Carbajal, D; González, J; Más, R; Mendoza, S; Molina, V; Noa, M, 2003) |
| "The protective effect of L-arginine and L-lysine on lysosomal enzymes and membrane bound ATPases was examined on isoproterenol induced myocardial infarction in rats." | 3.72 | Effect of L-arginine and L-lysine on lysosomal hydrolases and membrane bound phosphatases in experimentally induced myocardial infarction in rats. ( Devaki, T; Ebenezar, KK; Sathish, V, 2003) |
| "Rats treated with monocrotaline (MCT) develop pulmonary hypertension." | 3.72 | Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat. ( Brodde, OE; Hartmann, O; Hasenfuss, G; Kögler, H; Leineweber, K; Nguyen van, P; Schott, P, 2003) |
| "Animals with heart failure exhibited depressions in ventricular function, positive inotropic response to isoproterenol, beta-AR receptor density and basal AC activity; these changes were also attenuated by PLC treatment." | 3.72 | Improvement of cardiac function and beta-adrenergic signal transduction by propionyl L-carnitine in congestive heart failure due to myocardial infarction. ( Dhalla, NS; Ferrari, R; Sethi, R; Wang, X, 2004) |
| "Myocardial infarction was produced by subcutaneous administration of isoproterenol hydrochloride (85 mg/kg b." | 3.72 | Comparative account of certain enzymes in the serum of homo-iothermal vertebrates subjected to production of myocardial infarction by isoproterenol hydrochloride. ( Gaur, M; Kumar, S, 2003) |
| "Furosemide shortened the time to left ventricular dysfunction (35." | 3.72 | Furosemide and the progression of left ventricular dysfunction in experimental heart failure. ( Haigney, MC; Hanlon, SU; McCurley, JM; Michalski, M; Wedam, EF; Wei, SK, 2004) |
| "In rats, a toxic dosage of isoproterenol caused characteristic myocardial damage that subsequently resulted in mild heart failure." | 3.70 | Development of heart failure following isoproterenol administration in the rat: role of the renin-angiotensin system. ( Bruckschlegel, G; Elsner, D; Griese, D; Grimm, D; Kromer, EP; Muders, F; Pfeifer, M; Riegger, GA; Schunkert, H, 1998) |
| "This study demonstrates that isoproterenol-induced myocardial necrosis resulted in progressive hemodynamic dysfunction of the left ventricle which most closely correlated with alterations in LV geometry." | 3.70 | Effect of left ventricular sphericity on the evolution of ventricular dysfunction in rats with diffuse isoproterenol-induced myocardial necrosis. ( Pfeffer, JM; Pfeffer, MA; Teerlink, JR, 1998) |
| "Isoproterenol hydrochloride (ISO), a beta adrenergic agonist, is known to cause ischemic necrosis in rats." | 3.70 | Effect of a novel tetrapeptide derivative in a model of isoproterenol induced myocardial necrosis. ( Jayakumar, R; Jayasundar, S; Malarvannan, P; Puvanakrishnan, R; Ramesh, CV, 1998) |
| "We recently demonstrated that rapid ventricular pacing caused cardiac failure (Failure) in dogs with aortic stenosis-induced left ventricular hypertrophy (Hypertrophy) and isoproterenol caused no significant increases in function, O2 consumption and intracellular cyclic AMP level in the failing hypertrophied hearts." | 3.70 | Down regulation of myocardial beta1-adrenoceptor signal transduction system in pacing-induced failure in dogs with aortic stenosis-induced left ventricular hypertrophy. ( He, YQ; Huang, MW; Leone, RJ; Scholz, PM; Tse, J; Weiss, HR, 2000) |
| "Carvedilol, a selective alpha(1) and non-selective beta-adrenoceptor antagonist and antioxidant, has been shown to provide significant cardiac protection in animal models of myocardial ischemia." | 3.70 | Comparison of bisoprolol and carvedilol cardioprotection in a rabbit ischemia and reperfusion model. ( Chen, J; Christopher, TA; Gao, F; Gu, J; Lopez, BL; Lysko, P; Ma, XL; Ohlstein, EH; Ruffolo, RR; Yue, TL, 2000) |
| " Using radiotelemetry for monitoring cardiovascular parameters of spontaneously hypertensive rats treated with clonidine or moxonidine, we showed that clonidine, unlike moxonidine, resulted in rebound hypertension after drug withdrawal." | 3.69 | Mechanisms of cardiac cell damage due to catecholamines: significance of drugs regulating central sympathetic outflow. ( Dhalla, KS; Dhalla, NS; Rupp, H, 1994) |
| "The present study compared the effects of amrinone, dobutamine, dibutyryl cAMP, digoxin, and isoproterenol on mechanical performance, the high energy phosphate metabolites, and the [Ca2+]i transients in normal and cardiomyopathic hamster hearts with severe heart failure." | 3.69 | Distinct modulation of myocardial performance, energy metabolism, and [Ca2+]i transients by positive inotropic drugs in normal and severely failing hamster hearts. ( Buser, PT; Jasmin, G; Parmley, WW; Wikman-Coffelt, J; Wu, SY, 1995) |
| " Garlic dialysate suppressed premature ventricular contractions (PVC) and ventricular tachycardia (VT) in ouabain-intoxicated dogs as well as the ectopic rhythms induced by isoprenaline (10(-6) M) and aconitine (10(-8) M) on electrically driven left rat atria." | 3.69 | Anti-arrhythmic profile of a garlic dialysate assayed in dogs and isolated atrial preparations. ( Bardisa, L; Martín, N; Pantoja, C; Quezada, P; Valenzuela, J; Vargas, M, 1994) |
| " We investigated the regulation of the atrial natriuretic peptide and brain natriuretic peptide genes in a rat model of myocardial infarction induced by isoproterenol (IP rat) and in a rat model of cardiac hypertrophy induced by aorto-caval shunt (AC shunt rat)." | 3.69 | Differential regulation of natriuretic peptide genes in infarcted rat hearts. ( Iwai, N; Kinoshita, M; Shimoike, H, 1997) |
| " Angina pectoris was induced by methacholine or isoproterenol, and the change in the ST-segments in the electrocardiogram (ECG) was used as the parameter to indicate angina pectoris." | 3.68 | Effect of KRN2391, a novel vasodilator, on various experimental anginal models in rats. ( Fukata, Y; Fukushima, H; Harada, K; Kaneta, S; Miwa, A; Ogawa, N, 1993) |
| "Two experimental models of cardiac hypertrophy (chronic thyroxine or isoprenaline treatment of adult rats) were compared 24 h and five weeks after the agent was last given." | 3.68 | Functional changes in the right and left ventricle during development of cardiac hypertrophy and after its regression. ( Cihák, R; Kolár, F; Ostádal, B; Pelouch, V; Procházka, J; Widimský, J, 1992) |
| "The aim was to compare the effects of two novel angiotensin converting enzyme (ACE) inhibitors, spirapril and zofenopril, on cardiac remodelling in rats with congestive heart failure after myocardial infarction." | 3.68 | Converting enzyme inhibition after experimental myocardial infarction in rats: comparative study between spirapril and zofenopril. ( de Graeff, PA; de Langen, CD; Pinto, YM; van Gilst, WH; van Wijngaarden, J; Wesseling, H, 1991) |
| "Cardiac hypertrophy and failure were induced in male Wistar rats by daily administration of 5 mg/kg isoproterenol for three weeks." | 3.68 | Ultrastructural and electrophysiological alterations during the development of catecholamine-induced cardiac hypertrophy and failure. ( Lévai, G; Mészáros, J, 1990) |
| " Serum angiotensin converting enzyme activity (ACEA) and plasma renin activity (PRA) were determined in rats under different experimental conditions such as: nephrotic syndrome (NS), bilateral nephrectomy (BN), renovascular hypertension (RH), dehydration (DEH), anaesthesia (AN), low sodium diet (LSD) and high sodium diet (HSD), and injection with propranolol (PRO) and isoprenaline (ISO)." | 3.68 | Serum angiotensin converting enzyme activity and plasma renin activity in experimental models of rats. ( Cruz, C; Ibarra-Rubio, ME; Pedraza-Chaverrí, J; Peña, JC; Tapia, E, 1990) |
| "After antenatal induction of diaphragmatic hernias in fetal lambs, prostaglandins D2, E1, and I2 were compared to tolazoline, or isoprenaline, for the treatment of pulmonary hypertension." | 3.68 | Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline. ( Barker, AP; Ford, WD; Lee, CM; Sen, S, 1990) |
| "Two experimental animal models exhibiting functional and morphologic changes of exocrine glands similar to those seen in patients with cystic fibrosis (CF) have been reported in the rat: chronic stimulation with reserpine (Martinez et al." | 3.67 | Pulmonary function of the reserpine and isoproterenol models of cystic fibrosis. ( Boyd, RL; Fletcher, MT; Francis, EM; Mangos, JA, 1984) |
| "The chronically isoproterenol-treated rat has been proposed as an animal model for cystic fibrosis." | 3.67 | The chronically isoproterenol-treated rat in the study of cystic fibrosis: X-ray microanalysis of the submandibular gland. ( Müller, RM; Roomans, GM, 1984) |
| "The susceptibility of the cardiovascular system to exposure to a high-boiling coal liquid (heavy distillate, HD) was studied in the rat using an isoproterenol (ISO) myocardial infarction model." | 3.67 | Elevated blood pressure and heart rate in rats exposed to a coal-derived complex organic mixture. ( Lundstrom, DL; Mahlum, DD; Sasser, LB; Springer, DL; Zangar, RC, 1989) |
| "Elemental distribution and ultrastructure of the submandibular gland, the parotid gland and the pancreas were investigated in three suggested animal models of the disease cystic fibrosis: the chronically reserpinized rat, the chronically isoproterenol-treated rat, and the chronically pilocarpine-treated rat." | 3.67 | X-ray microanalysis of exocrine glands in animal models for cystic fibrosis. ( Müller, RM; Roomans, GM, 1985) |
| "Effects of prazosin, dobutamine, isoproterenol and SGB-1534, a new alpha-blockade, on congestive heart failure (CHF) in dogs were investigated." | 3.67 | [Effects of prazosin, SGB-1534, dobutamine and isoproterenol on congestive heart failure in dogs]. ( Sonoki, H; Sugimoto, T; Tomaru, T; Uchida, Y, 1988) |
| " To separately evaluate the ability of isoproterenol, a beta-adrenergic agonist, to prevent mediator release and anaphylactic shock, as well as to reverse the cardiopulmonary manifestations of systemic anaphylaxis, we administered a continuous infusion of isoproterenol before and during canine anaphylactic shock." | 3.67 | Prevention of canine anaphylaxis with isoproterenol. ( Bleecker, ER; Kagey-Sobotka, A; Lichtenstein, LM; Silverman, HJ; Smith, PL; Taylor, WR, 1986) |
| "In this work, we compared the electrophysiological and metabolic parameters of a volume overload model of cardiac hypertrophy (aorto-caval fistula) with those of two other models of hypertrophy (aortic stenosis and isoproterenol pretreatment)." | 3.67 | [Absence, in the hypertrophied rat heart caused by aortocaval fistula, of several metabolic and electrophysiological changes seen in other models of hypertrophy]. ( Aussedat, J; Kreher, P; Thollon, C; Verdetti, J, 1985) |
| "Chronic treatment of rats with reserpine, isoproterenol, or a combination of these two agents has been suggested as a means to produce an experimental animal model for the chronic exocrinopathy cystic fibrosis." | 3.67 | Changes in glycoconjugates in rat submandibular gland after chronic treatment with reserpine and isoproterenol. ( Maltarello, MC; Müller, RM; Roomans, GM; Versura, P, 1988) |
| "Heavy male Sprague-Dawley rats die of ventricular fibrillation within 2 to 3 h after isoproterenol administration." | 3.67 | Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death. ( Balazs, T; Ehrreich, SJ; el-Hage, AN; Johnson, GL, 1986) |
| "Ventricular fibrillation threshold was determined using a train of pulses, 4 ms in duration, delivered at 10 ms intervals, in 20 anaesthetised dogs receiving toxic doses of quinidine sulphate (30 mg X kg-1) injected intravenously over 5 min to prolong the QT interval." | 3.67 | Ventricular fibrillation threshold in canine hearts with quinidine induced prolonged QT interval: effects of atrial pacing, isoproterenol, and lignocaine. ( Inoue, H; Mashima, S; Matsuo, H; Murao, S; Sugimoto, T, 1986) |
| "Two different conditions responsible for cardiac hypertrophy in the rat were investigated: the first one is isoproterenol-induced myocardial infarct, the second is exposure to hypoxia (0." | 3.66 | Myocardial hypertrophy in the rat. Correlation between two experimental models. ( Cacciapuoti, AA; Chiariello, M; Condorelli, M; Ferro, G; Genovese, A, 1980) |
| "A high incidence of sudden death due to ventricular fibrillation (VF) has been observed in dogs under chronic treatment with probucol, a new hypocholesterolemic agent." | 3.66 | Adrenergaically mediated ventricular fibrillation in probucol-treated dogs: roles of alpha and beta adrenergic receptors. ( Besch, HR; Elharrar, V; Molello, J; Watanabe, AM; Zipes, DP, 1979) |
| "Adrenoceptor-mediated responses of the cardiovascular system during propylthiouracil-induced hypothyroidism were investigated." | 3.66 | Changes of adrenoceptor-mediated responses in the pithed rat during propylthiouracil-induced hypothyroidism. ( Borowski, E; Gross, G; Schümann, HJ, 1979) |
| "The effect of timolol, propranolol, epinephrine, and isoproterenol on intraocular pressure (IOP) (measured by tonometry) were compared after topical administration in conscious rabbits." | 3.65 | Comparison of the effects of timolol and other adrenergic agents on intraocular pressure in the rabbit. ( Le Douarec, JC; Plazonnet, B; Sears, ML; Silverstone, D; Stone, CA; Vareilles, P, 1977) |
| "Rats treated for 7 days with reserpine develop structural changes in the submaxillary gland that resemble those that have been reported in cystic fibrosis." | 3.65 | The chronically reserpinized rat as a possible model for cystic fibrosis. I. Submaxillary gland morphology and ultrastructure. ( Adelstein, E; Barbero, GJ; Martinez, JR; Quissel, D, 1975) |
| "Elevated calcium and protein concentration are a consistent abnormality in submaxillary saliva from patients with cystic fibrosis (CF) and from experimental animal models developed by the chronic administration of either isoproterenol (IPR) or reserpine." | 3.65 | The chronically reserpinized rat as a possible model for cystic fibrosis. VI. Synergistic effects of isoproterenol on Ca++ and protein in the submaxillary gland. ( Martinez, R; Wood, DL, 1977) |
| "Trapidil increases the isoprenalin-induced necrosis of the myocardium in the rat." | 3.65 | [Modification of the isoprenaline-induced myocardial necrosis using trapidil]. ( Lampe, D; Lange, B; Mai, I, 1976) |
| "Submaxillary saliva from reserpine-treated rats was found to have alterations in composition similar to those reported in the same secretion from patients with cystic fibrosis." | 3.65 | The chronically reserpinized rat as a possible model for cystic fibrosis. II. Comparison and cilioinhibitory effects of submaxillary saliva. ( Adshead, PC; Barbero, GJ; Martinez, JR; Quissell, DO, 1975) |
| "Male and female, arteriosclerotic and nonarteriosclerotic rats were subjected to acute myocardial infarction by two, subcutaneous injections (spaced 24 hr apart) of isoproterenol." | 3.65 | Metabolic and histopathologic changes in arteriosclerotic versus nonarteriosclerotic rats following isoproterenol-induced myocardial infarction with superimposed diabetes. ( Wexler, BC, 1975) |
| "Hyperammonemia is a feature of liver failure, which is associated with increased risk of infection." | 2.73 | Ammonia impairs neutrophil phagocytic function in liver disease. ( Davies, NA; Hodges, SJ; Jalan, R; Pitsillides, AA; Shawcross, DL; Stadlbauer, V; Wheeler-Jones, C; Wright, GA, 2008) |
| "Isoproterenol signaling was inhibited by administration of propranolol." | 1.91 | Radiation Therapy Exacerbates Tumor-Promoting Innervation and Nerve Signaling in Rectal Cancer. ( Drage, MG; Fleming, FJ; Garrett-Larsen, J; Gavras, NW; Gerber, SA; Gradzewicz, LB; Johnston, CJ; Kintzel, SA; Lesch, ML; Linehan, DC; Lord, EM; Love, TMT; Mills, BN; Murphy, JD; Qiu, H; Repasky, EA; Uccello, TP; Ullman, NA; Velagaleti, T; Ye, J, 2023) |
| "Rats were injected with ISO to induce cardiac hypertrophy and treated with MCP." | 1.62 | Modified citrus pectin prevents isoproterenol-induced cardiac hypertrophy associated with p38 signalling and TLR4/JAK/STAT3 pathway. ( Li, AY; Li, Y; Liu, WZ; Liu, XC; Song, QH; Sun, JH; Xu, GR; Yang, HX; Zhang, C; Zhang, Y; Zhou, WW, 2021) |
| "Ferruginol (FGL) is a major polyphenols and terpenoids with numerous pharmacological activities including antioxidant and anti-inflammatory." | 1.62 | Ameliorative effect of ferruginol on isoprenaline hydrochloride-induced myocardial infarction in rats. ( Ali Alharbi, S; Chen, Y; Deng, Y; Feng, J; Li, H; Li, X; Wang, C; Wang, L; Zhang, X, 2021) |
| " The ß-adrenergic agonist isoproterenol hydrochloride is used for its cardiac effects in a variety of different dosing regimens with high doses causing acute cardiomyocyte necrosis." | 1.62 | Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart. ( Baxan, N; Bedard, O; Benson, L; Boyle, JJ; Branca, J; Forte, E; Harding, SE; Hasham, MG; Ng, FS; Panahi, M; Rosenthal, N; Sattler, S, 2021) |
| "However, it failed to affect left ventricular hypertrophy and even aggravated the impaired positive and negative lusitropic effects elicited by isoprenaline and carbachol, respectively." | 1.62 | Chronic cannabidiol treatment reduces the carbachol-induced coronary constriction and left ventricular cardiomyocyte width of the isolated hypertensive rat heart. ( Gajo, B; Harasim-Symbor, E; Kasacka, I; Malinowska, B; Pędzińska-Betiuk, A; Schlicker, E; Toczek, M; Weresa, J, 2021) |
| "Isoproterenol was used as a surrogate for adrenergic stimulation both in vivo and in cardiomyocytes." | 1.62 | Discrete sites of frequent premature ventricular complexes cluster within the infarct border zone and coincide with high frequency of delayed afterdepolarizations under adrenergic stimulation. ( Amoni, M; Claus, P; De Buck, S; Dries, E; Ingelaere, S; Nagaraju, C; Roderick, HL; Sipido, KR; Vandenberk, B; Vermoortele, D; Willems, R, 2021) |
| " For pharmacodynamic study, histopathological and biochemical analysis were performed to assess the anti-myocardial ischemic effects." | 1.56 | Pharmacodynamics and pharmacokinetics of Danshen in isoproterenol-induced acute myocardial ischemic injury combined with Honghua. ( Bai, JQ; Chen, YY; Duan, JA; Liu, F; Qu, C; Shen, LF; Tang, YP; Wang, XP; Xu, DQ; Yue, SJ; Zhao, BC; Zhou, GS, 2020) |
| "Cardiac fibrosis is a common characteristic of many cardiac diseases." | 1.56 | Astragaloside IV inhibits cardiac fibrosis via miR-135a-TRPM7-TGF-β/Smads pathway. ( Feng, K; Tang, Y; Tao, R; Wei, Y; Wu, Y; Xu, H; Zhao, Y, 2020) |
| "A rat model of cardiac hypertrophy was induced by isoproterenol treatment (5 mg·kg-1·day-1) for 4 weeks, with or without ALS treatment at 20 mg·kg-1·day-1." | 1.56 | Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways. ( Guo, D; Liu, H; Zhao, Z, 2020) |
| "Cardiac hypertrophy was induced in the zebrafish following a pretreatment with erythromycin (ERY), and the onset and reconciliation of disease by YDR were determined using a treadmill electrocardiogram, heart anatomy analysis, C-reactive protein release, and platelet aggregation time-analysis." | 1.56 | Application of Zebrafish Model in the Suppression of Drug-Induced Cardiac Hypertrophy by Traditional Indian Medicine Yogendra Ras. ( Balkrishna, A; Bhattacharya, K; Rustagi, Y; Varshney, A, 2020) |
| "Ginkgolides are widely used in cardio-protective therapy; however, poor bioavailability currently limits their application." | 1.56 | Preparation of Ginkgolide Solid Dispersions with Low-Molecular-Weight Chitosan and Assessment of their Protective Effect on Isoproterenol- Induced Myocardial Injury. ( Cui, L; Ding, W; Liu, B; Liu, D; Xia, Z; Zhang, L, 2020) |
| " We hypothesized that experimental diabetes in rats combined with a cardiac or renal stressor, would mimic diabetic cardiomyopathy and nephropathy, respectively." | 1.56 | Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy. ( Fink, LN; Jelsing, J; Johansen, TT; Lindsay, RT; Murray, AJ; Pedersen, AA; Pedersen, PJ; Pedersen, TX; Secher, T; Skarsfeldt, T; Thisted, L; Thomsen, MB; Thrane, ST; Zois, NE; Østergaard, MV, 2020) |
| "Cardiac fibrosis is a crucial aspect of cardiac remodeling that can severely affect cardiac function." | 1.51 | Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats. ( Che, Y; Jin, YG; Shen, DF; Wang, SS; Wang, ZP; Wu, QQ; Yuan, Y, 2019) |
| "Isoproterenol (ISO), is a non-selective beta-adrenergic agonist, that is used widely to induce cardiac injury in mice." | 1.51 | Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice. ( Chang, S; Mandelli, A; Ren, S; Tran, A; Wang, JJ; Wang, Y, 2019) |
| "Patients with Duchenne muscular dystrophy (DMD) commonly present with severe ventricular arrhythmias that contribute to heart failure." | 1.51 | S-nitrosylation of connexin43 hemichannels elicits cardiac stress-induced arrhythmias in Duchenne muscular dystrophy mice. ( Contreras, JE; Fraidenraich, D; Himelman, E; Lillo, MA; Shirokova, N; Xie, LH, 2019) |
| "Plantamajoside (PMS) is an active component extracted from Herba Plantaginis, which is a traditional Chinese medicine, and many biological activities of PMS have been reported." | 1.51 | Plantamajoside attenuates isoproterenol-induced cardiac hypertrophy associated with the HDAC2 and AKT/ GSK-3β signaling pathway. ( Hou, M; Liu, Y; Pin, L; Shang, L; Shun, M; Zhang, Y; Zhong, X; Zhu, S, 2019) |
| "Diosmin pretreatment showed significant preventive effects on all the biochemical parameters, and the structure of mitochondria was evaluated." | 1.48 | Diosmin Prevents Isoproterenol-Induced Heart Mitochondrial Oxidative Stress in Rats. ( John, B; Sharmila Queenthy, S; Stanely Mainzen Prince, P, 2018) |
| "Pretreatment with kaempferol at highest dose showed mild mononuclear infiltration and degenerative changes in heart tissue section of myocardial injured rats." | 1.48 | Effect of Kaempferol Pretreatment on Myocardial Injury in Rats. ( Kandasamy, A; Kumar, A; Kumar, D; Kumar, T; Lingaraju, MC; Parida, S; Rungsung, S; Singh, TU; Vishwakarma, A, 2018) |
| " Wistar rats were dosed once with either isoproterenol (1." | 1.48 | miR-21-5p as a potential biomarker of inflammatory infiltration in the heart upon acute drug-induced cardiac injury in rats. ( De Ron, P; Fleming, A; Fleurance, R; Gryshkova, V; McGhan, P; Nogueira da Costa, A; Valentin, JP, 2018) |
| "Levosimendan has vasorelaxant and anti-aggregatory properties." | 1.48 | Cardioprotective and Anti-Aggregatory Effects of Levosimendan on Isoproterenol-Induced Myocardial Injury in High-Fat-Fed Rats Involves Modulation of PI3K/Akt/mTOR Signaling Pathway and Inhibition of Apoptosis: Comparison to Cilostazol. ( El-Kherbetawy, MK; Makary, S; Tawfik, MK, 2018) |
| "Cardiac fibrosis is a common feature of many cardiac pathophysiologic conditions." | 1.48 | Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome. ( Qi, R; Tuerdi, N; Wan, Y; Wang, Y; Xu, L; Ye, M, 2018) |
| "Sudden cardiac death from ventricular arrhythmias is more common in adult patients with with heart failure compared with pediatric patients with heart failure." | 1.48 | Acute isoproterenol leads to age-dependent arrhythmogenesis in guinea pigs. ( Chau, S; Miyamoto, SD; Nau, S; Phillips, EK; Stauffer, BL; Sucharov, CC; Tompkins, C; Wilson, CE; Woulfe, KC; Zang, S, 2018) |
| "The treatment of cycloastragenol improved deranged cardiac parameters in the isoproterenol-induced heart damage model in a dose-dependent manner." | 1.48 | Cycloastragenol ameliorates experimental heart damage in rats by promoting myocardial autophagy via inhibition of AKT1-RPS6KB1 signaling. ( Cai, H; Cao, SP; Song, YH; Wang, J; Wu, ML; Zhao, ZM, 2018) |
| "Hypertension is a major cause of left ventricular (LV) diastolic dysfunction." | 1.48 | Limited Impact of β-Adrenergic Receptor Activation on Left Ventricular Diastolic Function in Rat Models of Hypertensive Heart Disease. ( Bamaiyi, AJ; Mojiminiyi, FB; Norman, G; Norton, GR; Peterson, V; Woodiwiss, AJ, 2018) |
| " At the end of dosing left ventricular functions was assessed to estimate its effect on cardiac functions." | 1.46 | Cardiaprotective effect of crocetin by attenuating apoptosis in isoproterenol induced myocardial infarction rat model. ( Ge, Z; Li, Y; Zhang, W, 2017) |
| "Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions." | 1.43 | HDAC6 Promotes Cardiac Fibrosis Progression through Suppressing RASSF1A Expression. ( Hu, W; Li, J; Shi, KH; Tao, H; Yang, JJ, 2016) |
| "While Huntington's disease (HD) is classified as a neurological disorder, HD patients exhibit a high incidence of cardiovascular events leading to heart failure and death." | 1.43 | Cardiac Dysfunction in the BACHD Mouse Model of Huntington's Disease. ( Colwell, CS; Coppola, G; Fishbein, MC; Gao, F; Ghiani, CA; Jordan, MC; Park, S; Roos, KP; Schroeder, AM; Wang, HB, 2016) |
| "Acute myocardial infarction is a serious acute cardiac disorder and heart disease is still a major public health problem in adults." | 1.43 | Molecular and biochemical evidence on the protective effects of embelin and carnosic acid in isoproterenol-induced acute myocardial injury in rats. ( Akcilar, R; Altuntas, I; Bayat, Z; Isiklar, OO; Kocak, C; Kocak, FE; Kocak, H; Simsek, H; Taser, F, 2016) |
| "However, early detection of cardiac hypertrophy is difficult by the currently used non-invasive method and new approaches are in urgent need for efficient diagnosis of cardiac malfunction." | 1.43 | Speckle Tracking Based Strain Analysis Is Sensitive for Early Detection of Pathological Cardiac Hypertrophy. ( An, X; Bai, Y; Li, H; Lu, Z; Song, Y; Wang, J; Xiao, H; Zhang, Y, 2016) |
| "To evaluate the role of miR-99a in cardiac hypertrophy, we assessed the expression of miR-99a in hypertrophic cardiomyocytes induced by isoprenaline (ISO)/angiotensin-II (Ang II) and in mice model of cardiac hypertrophy induced by transverse aortic constriction (TAC)." | 1.43 | Overexpression of microRNA-99a Attenuates Cardiac Hypertrophy. ( Bai, J; Ding, L; Gu, R; Li, Q; Li, R; Wang, B; Wang, L; Xie, J; Xu, B, 2016) |
| "Isorhapontigenin is a derivative of stilbene with chemical structure similar to resveratrol." | 1.43 | Cardioprotective effect of resveratrol analogue isorhapontigenin versus omega-3 fatty acids in isoproterenol-induced myocardial infarction in rats. ( Abbas, AM, 2016) |
| "We used a mouse model of Chuvash polycythemia (CP), a rare genetic disorder that modestly increases expression of HIF target genes in normoxia, to understand what these effects might be within the heart." | 1.43 | The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high-energy phosphate metabolism. ( Carr, C; Clarke, K; Cole, M; Curtis, MK; Dodd, M; Giles, L; Heather, LC; Robbins, PA; Slingo, M; Tyler, D, 2016) |
| "Zingerone pretreatment significantly (P<0." | 1.43 | Anti-inflammatory and anti-thrombotic effects of zingerone in a rat model of myocardial infarction. ( Hemalatha, KL; Stanely Mainzen Prince, P, 2016) |
| "Gallic acid pretreatment attenuated concentric cardiac hypertrophy." | 1.43 | Gallic acid prevents isoproterenol-induced cardiac hypertrophy and fibrosis through regulation of JNK2 signaling and Smad3 binding activity. ( Cho, JY; Choi, SY; Jeong, MH; Jin, L; Kee, HJ; Kim, GR; Lin, MQ; Piao, ZH; Ryu, Y, 2016) |
| " In conclusion, the present study indicated that chronic use of KATP channel agonists following cardiac hypertrophy can attenuate ventricular remodeling and upregulate the expression level and spatial distribution of Cx43." | 1.42 | Reduction of isoproterenol-induced cardiac hypertrophy and modulation of myocardial connexin43 by a KATP channel agonist. ( Gu, J; Guo, Z; Hao, YY; Sun, JM; Wang, AL; Wang, CM; Xie, YJ, 2015) |
| "Pretreatment with zingerone (vanillyl acetone) revealed preventive effects on tachycardia, LVH, ECG, and all the above mentioned biochemical parameters evaluated in isoproterenol induced myocardial infarcted rats." | 1.42 | A biochemical and 2, 3, 5-triphenyl tetrazolium chloride staining study on the preventive effects of zingerone (vanillyl acetone) in experimentally induced myocardial infarcted rats. ( Hemalatha, KL; Stanely Mainzen Prince, P, 2015) |
| "In pilocarpine-treated animals, β-AR-mediated LTP was strongly reduced in the distal subiculum." | 1.42 | Gating of hippocampal output by β-adrenergic receptor activation in the pilocarpine model of epilepsy. ( Bartsch, JC; Behr, J; Gilling, KE; Grosser, S; Heinemann, U; Hollnagel, JO, 2015) |
| "Dantrolene treatment markedly reduced the rise of [Ca(2+)]i levels caused by chronic administration of ISO (P < ." | 1.42 | Effects of Dantrolene Treatment on Ventricular Electrophysiology and Arrhythmogenesis in Rats With Chronic β-Adrenergic Receptor Activation. ( Huang, CX; Liu, T; Qin, M; Shi, SB, 2015) |
| "Fibrosis was markedly increased by ISO." | 1.42 | l-Arginine Attenuates Cardiac Dysfunction, But Further Down-Regulates α-Myosin Heavy Chain Expression in Isoproterenol-Induced Cardiomyopathy. ( Babal, P; Doka, G; Janega, P; Klimas, J; Kralova, E; Krenek, P; Kuracinova, K; Pivackova, L; Srankova, J, 2015) |
| "No mouse showed ventricular arrhythmias in all of the 4 groups." | 1.42 | [Combined transgenic inhibition of CaMKII and Ik1 on cardiac remodeling]. ( Cui, TP; Dai, M; Du, XL; Du, YM; Huang, Y; Li, JD; Shu, YW; Su, GH; Yao, YF; Zhang, JM, 2015) |
| "Nephrotic syndrome is a renal disease accompanied by abnormal body fluid balance." | 1.42 | Thirst and sodium appetite in rats with experimental nephrotic syndrome. ( Johnson, AK; Thunhorst, RL; Xu, J, 2015) |
| "Hypertrophy was restored on NOS or protein kinase G inhibition." | 1.40 | Enhanced expression of β3-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase. ( Balligand, JL; Beauloye, C; Belge, C; Bertrand, L; Dessy, C; Dubois-Deruy, E; Esfahani, H; Götz, KR; Hamelet, J; Hammond, J; Herijgers, P; Hilfiker-Kleiner, D; Iaccarino, G; Jnaoui, K; Langin, D; Lobysheva, I; Manoury, B; Markl, A; Nikolaev, VO; Pouleur, AC; Tavernier, G; Vanderper, A, 2014) |
| "Isoproterenol (ISO) has been reported to inhibit high mobility group box 1 (HMGB1) protein release via heme oxygenase-1 (HO-1) induction in lipopolysaccharide (LPS)-activated RAW 264." | 1.40 | Isoproterenol‑mediated heme oxygenase‑1 induction inhibits high mobility group box 1 protein release and protects against rat myocardial ischemia/reperfusion injury in vivo. ( Fu, W; Hu, X; Jiang, H; Wang, J; Xie, J; Zhou, X, 2014) |
| "Isoproterenol twice treated fetuses exhibited significant changes in histological evaluation, and mitochondrial damages were significantly severe with increased apoptotic rate." | 1.40 | The study of fetal rat model of intra-amniotic isoproterenol injection induced heart dysfunction and phenotypic switch of contractile proteins. ( Fang, J; Hua, Y; Li, Y; Mu, D; Wang, C; Zhou, K, 2014) |
| "Isoproterenol (100 mg/kg) was injected subcutaneously for two consecutive days to induce myocardial infarction, and simultaneously tacrolimus was administered orally twice a day for three days." | 1.40 | Tacrolimus ameliorates functional disturbances and oxidative stress in isoproterenol-induced myocardial infarction. ( Garjani, A; Garjani, M; Hammami, M; Khorrami, A; Maleki-Dizaji, N, 2014) |
| "Also HRC-null mice exhibited severe cardiac hypertrophy, fibrosis, pulmonary edema and decreased survival after TAC." | 1.39 | Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress. ( Bers, DM; Cha, H; Chen, S; Cho, C; Franzini-Armstrong, C; Ginsburg, KS; Han, P; Hong, S; Jin, S; Kim, DH; Kranias, EG; Lee, H; Oh, JG; Park, CS; Park, I; Park, WJ; Singh, VP; Wang, HS, 2013) |
| "Isoproterenol was administered twice to female Wistar rats (170 mg/kg, s." | 1.39 | Ventricular repolarization in a rat model of global heart failure. ( Kharin, S; Krandycheva, V; Shmakov, D; Shumikhin, K; Sobolev, A; Strelkova, M, 2013) |
| "In isoproterenol-treated DBA/2 mice, there was also a greater expression level of the hypertrophy marker, ANF, compared to C57BL/6 mice." | 1.39 | Mouse strain determines cardiac growth potential. ( Grimes, B; Kiper, C; Satin, J; Van Zant, G, 2013) |
| "Heart failure was induced by isoprenaline s." | 1.39 | Chronic inhibition of cGMP-specific phosphodiesterase 5 suppresses endoplasmic reticulum stress in heart failure. ( Cai, Z; Chen, C; Cianflone, K; Duan, Q; Gong, W; Ni, L; Wang, DW; Wang, X; Yan, M, 2013) |
| "Cardiac hypertrophy is associated with a switch towards increased glucose metabolism and decreased fatty acid metabolism." | 1.39 | Cardiac-specific hexokinase 2 overexpression attenuates hypertrophy by increasing pentose phosphate pathway flux. ( Baines, CP; Douglas, DL; Krenz, M; McCommis, KS, 2013) |
| "Isoproterenol was injected subcutaneously (30 mg/kg BW, twice, at an interval of 24 hours) on the day 70 of the study, when plasma and erythrocyte Mg level in rats fed a low Mg diet were significantly decreased by 47% and 45% compared to intact animals." | 1.39 | [Correction of isoproterenol-induced myocardial injury with magnesium salts in magnesium-deficient rats]. ( Iezhitsa, IN; Kharitonova, MV; Pan'shin, NG; Smirnov, AV; Spasov, AA; Zheltova, AA, 2013) |
| "Isoproterenol treatment caused significant increase in mitochondrial lipid peroxides and lipids except phospholipids with significant decrease in mitochondrial antioxidants." | 1.39 | An in vivo and in vitro study on the protective effects of N-acetylcysteine on mitochondrial dysfunction in isoproterenol treated myocardial infarcted rats. ( Basha, RH; Priscilla, DH, 2013) |
| "In addition, induction of cardiac hypertrophy by ISO caused remarkable induction in CT-1 mRNA and protein expression levels by approximately 3." | 1.39 | Downregulation of the cardiotrophin-1 gene expression by valsartan and spironolactone in hypertrophied heart rats in vivo and rat cardiomyocyte H9c2 cell line in vitro: a novel mechanism of cardioprotection. ( Al-Mazroua, HA; Al-Rasheed, NM; Korashy, HM, 2013) |
| "We also observed polymorphic ventricular tachycardia in the CASQ2(D307H) mice, although lesser than in the CASQ2 null mice." | 1.38 | Functional consequences of stably expressing a mutant calsequestrin (CASQ2D307H) in the CASQ2 null background. ( Belevych, AE; Gyorke, S; Hwang, HS; Kalyanasundaram, A; Knollmann, BC; Lacombe, VA; Periasamy, M; Viatchenko-Karpinski, S, 2012) |
| "Isoproterenol was administered subcutaneously." | 1.38 | Beta-adrenoreceptor agonism influences retinal responses to hypoxia in a model of retinopathy of prematurity. ( Bagnoli, P; Dal Monte, M; Filippi, L; Latina, V; Martini, D; Pavan, B, 2012) |
| "Catecholaminergic polymorphic ventricular tachycardia is characterized by stress-triggered syncope and sudden death." | 1.38 | Paradoxical effect of increased diastolic Ca(2+) release and decreased sinoatrial node activity in a mouse model of catecholaminergic polymorphic ventricular tachycardia. ( Benitah, JP; Gómez, AM; Liu, N; Mangoni, ME; Mesirca, P; Napolitano, C; Neco, P; Priori, SG; Richard, S; Torrente, AG; Zorio, E, 2012) |
| "AV block was created in dogs to induce ventricular remodeling, including enhanced susceptibility to dofetilide-induced torsades de pointes arrhythmias." | 1.38 | Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog. ( Antoons, G; Beekman, JD; Bourgonje, VJ; de Windt, LJ; Houtman, MJ; Miedema, LF; Schoenmakers, M; Sipido, K; van der Nagel, R; van Veen, TA; Vos, MA, 2012) |
| "Therefore, we can conclude that cardiac hypertrophy led to a reduced sensitivity of baroreflex control of RSNA." | 1.38 | Baroreflex control of renal sympathetic nerve activity in mice with cardiac hypertrophy. ( Abreu, GR; Balarini, CM; Cabral, AM; Gava, AL; Meyrelles, SS; Peotta, VA; Vasquez, EC, 2012) |
| "Sesamol is a potent phenolic antioxidant contained only in processed sesame oil and possesses potent chemopreventive, antimutagenic, antihepatotoxic and antioxidation properties." | 1.38 | Efficacy of sesamol on plasma and tissue lipids in isoproterenol-induced cardiotoxicity in Wistar rats. ( Pugalendi, KV; Vennila, L, 2012) |
| "Isoproterenol is a synthetic catecholamine found to cause toxicity leading to severe stress in the myocardium of experimental animals." | 1.37 | Cardioprotective effect of lemon grass as evidenced by biochemical and histopathological changes in experimentally induced cardiotoxicity. ( Gayathri, K; Jayachandran, KS; Rajamanickam, GV; Vasanthi, HR, 2011) |
| "Vanillic acid pretreated isoproterenol-induced rats positively altered all the above-mentioned biochemical parameters." | 1.37 | Preventive effects of vanillic acid on lipids, bax, bcl-2 and myocardial infarct size on isoproterenol-induced myocardial infarcted rats: a biochemical and in vitro study. ( Dhanasekar, K; Prince, PS; Rajakumar, S, 2011) |
| " Isoprenaline (ISO), a β-adrenoceptor agonist, was infused at variable dosage and duration using either subcutaneously implanted osmotic minipumps or daily injections, in an attempt to establish the relevant treatment protocol." | 1.37 | Myocardial structural, contractile and electrophysiological changes in the guinea-pig heart failure model induced by chronic sympathetic activation. ( Olesen, SP; Osadchii, OE; Soltysinska, E, 2011) |
| "Cardiomyopathy in Duchenne muscular dystrophy (DMD) is an increasing cause of death in patients." | 1.37 | Membrane sealant Poloxamer P188 protects against isoproterenol induced cardiomyopathy in dystrophin deficient mice. ( Guerron, AD; Hoffman, EP; Nagaraju, K; Sali, A; Spurney, CF; van der Meulen, JH; Yu, Q, 2011) |
| "Nearly universal cardiomyopathy in Duchenne muscular dystrophy (DMD) contributes to heart failure and death." | 1.37 | Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice. ( Canan, BD; Chimanji, NS; Delfín, DA; Ganguly, R; Janssen, PM; Martin, CD; Mays, TA; Murray, JD; Rafael-Fortney, JA; Raman, SV; Schill, KE; Stangland, JE; Tran, T; Xu, Y, 2011) |
| "ISO-induced cardiac hypertrophy and Erk1/2 activation in Pak-1-KO/ISO were attenuated when the selective Erk1/2 inhibitor FR180204 was administered." | 1.37 | Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. ( Chernoff, J; Ke, Y; Knezevic, I; Lei, M; Monasky, MM; Sheehan, KA; Solaro, RJ; Taglieri, DM; Wang, X; Wolska, BM, 2011) |
| "The hydroxyproline contents were investigated by spectrophotometric measurement." | 1.37 | [Protective effects of Leonurus japonicas on myocardial remodeling induced by isoproterenol in rats]. ( Gu, YP; Guo, W; Liu, Y; Lv, R; Wei, HC; Yuan, BP; Zhang, C, 2011) |
| "In vivo, cardiac hypertrophy was induced by injection of ISO (5 mg." | 1.36 | KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways. ( Chen, IJ; Dai, ZK; Hsu, JH; Liou, SF; Liu, CP; Wu, BN; Wu, JR; Wu, PJ; Yeh, JL, 2010) |
| "Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by a single point mutation in a well-defined region of the cardiac type 2 ryanodine receptor (RyR)2." | 1.36 | Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor. ( Doi, M; Ikeda, Y; Ikemoto, N; Kobayashi, S; Matsuzaki, M; Oda, T; Ohkusa, T; Okuda, S; Ono, M; Suetomi, T; Tateishi, H; Uchinoumi, H; Xu, X; Yamamoto, T; Yano, M, 2010) |
| "Isoproterenol-induced PAD was unchanged by H/I, EEIIMD, SB-203580, and SP-600125." | 1.36 | PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia. ( Armstead, WM; Cines, DB; Higazi, AA; Kiessling, JW; Riley, J, 2010) |
| "Isoprenaline-induced cardiac hypertrophy was associated with increased expression of beta myosin heavy chain, which was also prevented by Ro5-4864." | 1.36 | Peripheral benzodiazepine receptor ligand Ro5-4864 inhibits isoprenaline-induced cardiac hypertrophy in rats. ( Dinda, AK; Enjamoori, R; Jaiswal, A; Kumar, S; Maulik, SK; Seth, S, 2010) |
| "Subclinical hypothyroidism has been linked to cystic fibrosis, and the cystic fibrosis transmembrane conductance regulator (CFTR) shown to be expressed in the thyroid." | 1.36 | Altered ion transport by thyroid epithelia from CFTR(-/-) pigs suggests mechanisms for hypothyroidism in cystic fibrosis. ( Fong, P; Ganta, S; Li, H, 2010) |
| "Verapamil response was significantly correlated with cTnI." | 1.36 | Drug-disease interaction: reduced verapamil response in isoproterenol-induced myocardial injury in rats. ( El-Kadi, AO; Hanafy, S; Jamali, F, 2010) |
| "The ventricular remodeling of mice were induced by subcutaneous injection of ISO with the dosage of 2 mg/kg daily for 7 d and the rats with L-Thy intraperitoneally with the dosage of 0." | 1.36 | [Effect of Chrysanthemum indicum on ventricular remodeling in rats]. ( Chen, CX; Gao, JP; Gu, WL; Lv, J; Wan, Y; Wu, Q, 2010) |
| "Treatment with isoproterenol (iso) for 7 days caused myocardial damage and left ventricular (LV) dysfunction in the cardiomyopathic mice." | 1.35 | Granulocyte-colony stimulating factor increases donor mesenchymal stem cells in bone marrow and their mobilization into peripheral circulation but does not repair dystrophic heart after bone marrow transplantation. ( Adachi, Y; Enoki, C; Ikehara, S; Imamura, H; Iwasaka, T; Kaneko, K; Otani, H; Sato, D; Taniuchi, S; Tatsumi, K, 2008) |
| "Pretreatment with mangiferin (100 mg/kg body weight, intraperitoneally) for 28 days, significantly prevented the alterations and restored the enzyme activities to near-normal status." | 1.35 | Mechanism of protective action of mangiferin on suppression of inflammatory response and lysosomal instability in rat model of myocardial infarction. ( Devi, CS; Narayan, S; Prabhu, S, 2009) |
| "However, the role of RALT in cardiac hypertrophy remains unclear." | 1.35 | Targeted expression of receptor-associated late transducer inhibits maladaptive hypertrophy via blocking epidermal growth factor receptor signaling. ( Bian, ZY; Cai, J; Ghosh, AK; Li, A; Li, H; Shen, DF; Tang, QZ; Yan, L; Yang, L; Yang, Q; Yang, XC; Yi, FF, 2009) |
| "Pretreatment with gallic acid (15 mg/kg) to isoproterenol treated rats significantly (P<0." | 1.35 | Gallic acid prevents lysosomal damage in isoproterenol induced cardiotoxicity in Wistar rats. ( Devika, PT; Priscilla, H; Stanely Mainzen Prince, P, 2009) |
| "Cardiac hypertrophy is associated with a reduction in the contractile response to beta-adrenergic stimulation, and with re-expression of foetal genes such as beta-myosin heavy chain (MHC)." | 1.35 | Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain. ( Pandya, K; Porter, K; Rockman, HA; Smithies, O, 2009) |
| "Cardiac hypertrophy is accompanied by maladaptive cardiac remodeling, which leads to heart failure or sudden death." | 1.35 | miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy. ( Gao, J; Jiao, J; Li, PF; Lin, Z; Murtaza, I; Wang, K, 2009) |
| "Isoproterenol treatment (80 mg/kg given over 2 days in two equal doses) caused arrhythmias and 60% mortality within 24 h of the last injection in the control group (C + ISO) group when compared with the saline control group (saline)." | 1.35 | Exercise training provides cardioprotection via a reduction in reactive oxygen species in rats submitted to myocardial infarction induced by isoproterenol. ( Barbosa, VA; Boeck, CR; Da Luz, G; Da Silva, S; De Pinho, RA; De Souza, CT; Frederico, MJ; Justo, SL; Medeiros, C; Silva, LA, 2009) |
| "Amiodarone was administered to groups of rats once per day for 30 days." | 1.35 | Preventive effect of amiodarone during acute period in isoproterenol-induced myocardial injury in Wistar rats. ( Albayrak, F; Bakan, E; Bayir, Y; Bayram, E; Halici, Z; Kabalar, E; Keles, MS; Kurt, M; Ozturk, C; Suleyman, H, 2009) |
| "Approximately 40% of patients with type 2 diabetes present with concurrent hypertension at the time of diabetes diagnosis." | 1.35 | Decreased NO signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertension. ( Behnke, BJ; Delp, MD; Donato, AJ; Laughlin, MH; Lesniewski, LA; Ray, CA; Woodman, CR, 2008) |
| " By 48 hours the hearts of rats dosed with 125-500 mug/kg Iso had developed interstitial fibrosis, and serum cTnT had declined to near control levels (0." | 1.35 | Isoproterenol-induced cardiotoxicity in sprague-dawley rats: correlation of reversible and irreversible myocardial injury with release of cardiac troponin T and roles of iNOS in myocardial injury. ( Herman, EH; Knapton, A; Lipshultz, SE; Weaver, JL; Zhang, J, 2008) |
| "It is now well established that hydrocephalus is associated with impaired bladder function." | 1.35 | Alterations in the mechanical properties of bladder smooth muscle in hydrocephalus rat model. ( Etuş, V; Tugay, M; Tugay, S; Utkan, T; Yazir, Y, 2008) |
| "Rats with congestive heart failure (CHF) develop ventricular inotropic responsiveness to serotonin (5-HT), mediated through 5-HT(2A) and 5-HT(4) receptors." | 1.34 | Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes. ( Birkeland, JA; Enger, U; Levy, FO; Lunde, PK; Qvigstad, E; Sejersted, OM; Sjaastad, I; Swift, F; Tovsrud, N, 2007) |
| "Hyperthyroidism was induced by subcutaneous injections of L-thyroxine (T4) (0." | 1.33 | Comparison of muscarinic receptor- and beta-adrenoceptor-mediated vasorelaxation between euthyroid and acute hyperthyroid rats. ( Honda, H; Iwata, T; Kondo, M; Kumasaka, K; Matsuda, H; Moroe, H, 2005) |
| " All agents were also toxic to the soleus muscle (range 0." | 1.33 | Relative toxicity of cardiotonic agents: some induce more cardiac and skeletal myocyte apoptosis and necrosis in vivo than others. ( Burniston, JG; Clark, WA; Ellison, GM; Goldspink, DF; Tan, LB, 2005) |
| "Pretreatment with mangiferin (100 mg/kg b." | 1.33 | Effect of mangiferin on mitochondrial energy production in experimentally induced myocardial infarcted rats. ( Jainu, M; Prabhu, S; Sabitha, KE; Shyamala Devi, CS, 2006) |
| "Because heart failure is a progressive disease that often evolves from hypertrophy, we analyzed the RyR2 macromolecular complex in several animal models of cardiomyopathy that lead to heart failure, including hypertrophy, and at different stages of disease progression." | 1.32 | Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts. Role of phosphatases and response to isoproterenol. ( Burkhoff, D; D'Armiento, J; Gaburjakova, M; Gomez, AM; Guatimosim, S; Lederer, WJ; Marks, AR; Reiken, S; Vassort, G; Wang, J, 2003) |
| "The isoproterenol-stimulated increase in I Ca(L) was significantly smaller in postinfarction myocytes (Emax: 63." | 1.32 | Impaired beta-adrenergic response and decreased L-type calcium current of hypertrophied left ventricular myocytes in postinfarction heart failure. ( Chedid, NG; Díaz G, LE; Masuda, MO; Quintero H, CC; Saraiva, RM, 2003) |
| "Isoproterenol caused an increase in the level of cyclic AMP (rho;moles/10(5) myocytes) in the control (from 2." | 1.32 | Effects of triiodothyronine pretreatment on beta-adrenergic responses in stunned cardiac myocytes. ( Gandhi, A; He, YQ; Tse, J; Weiss, HR; Yan, L, 2003) |
| "The present study was designed to investigate the effects of chronic administration of the alcoholic extract of Terminalia arjuna (TAAE) bark on isoproterenol induced myocardial injury." | 1.32 | Cardioprotective effect of the alcoholic extract of Terminalia arjuna bark in an in vivo model of myocardial ischemic reperfusion injury. ( Bai, BR; Devaraj, SN; Gauthaman, K; Karthikeyan, K; Sathish, KS, 2003) |
| "Moreover, scar size was significantly smaller (16 +/- 6% vs." | 1.32 | Treatment of acute myocardial infarction by hepatocyte growth factor gene transfer: the first demonstration of myocardial transfer of a "functional" gene using ultrasonic microbubble destruction. ( Fuke, S; Kohno, M; Kondo, I; Namba, T; Noma, T; Ohmori, K; Oshita, A; Shinomiya, K; Takeuchi, H, 2004) |
| "Since heart failure is also associated with attenuated responses to catecholamines, we examined the effects of imidapril, an ACE inhibitor, on the beta-adrenoceptor (beta-AR) signal transduction in the failing heart." | 1.32 | Changes in beta-adrenoceptors in heart failure due to myocardial infarction are attenuated by blockade of renin-angiotensin system. ( Dhalla, NS; Ren, B; Saini, HK; Sethi, R; Shao, Q; Takeda, N, 2004) |
| "Myocardial infarction is usually induced in small animals by means of invasive procedures: the aim of this study was to cause heart necrosis lesions by non-invasive means." | 1.32 | Myocardial infarction non-invasively induced in rabbits by administering isoproterenol and vasopressin: protective effects exerted by verapamil. ( Bertolini, B; Bonacina, E; Brenna, S; Pinelli, A; Tomasoni, L; Trivulzio, S; Vignati, S, 2004) |
| " This toxic damage was initiated at lower doses of isoprenaline than in the myocardium (1 vs." | 1.31 | Characterisation of isoprenaline myotoxicity on slow-twitch skeletal versus cardiac muscle. ( Burniston, JG; Clark, WA; Colyer, J; Goldspink, DF; Ng, Y; Tan, LB, 2002) |
| "Stunned myocardium is a syndrome of reversible contractile failure that frequently complicates coronary artery disease." | 1.31 | Transgenic mouse model of stunned myocardium. ( Georgakopoulos, D; Kass, DA; Kögler, H; Marbán, E; McDonough, JL; Murphy, AM; Van Eyk, JE, 2000) |
| "The effects of high-dose epinephrine (HDE) combined with isoprenaline (Iso) on myocardial hemodynamics of isolated rabbit heart were studied." | 1.31 | The effects of high-dose epinephrine combined with isoprenaline on isolated rabbit heart and cardiomyocytes after cardioversion of ventricular fibrillation. ( Zhang, W; Zhao, L; Zheng, Y, 2000) |
| "Selegiline is a centrally acting sympatholytic agent with neuroprotective properties." | 1.31 | Selegiline improves cardiac sympathetic terminal function and beta-adrenergic responsiveness in heart failure. ( Dong, E; Kawai, H; Liang, CS; Shite, J; Stevens, SY, 2000) |
| "Cardiac hypertrophy was induced in rats by chronic s." | 1.31 | Protein phosphatase activity is increased in a rat model of long-term beta-adrenergic stimulation. ( Bokník, P; Fockenbrock, M; Herzig, S; Knapp, J; Linck, B; Lüss, H; Müller, FU; Müller, T; Neumann, J; Schmitz, W; Schröder, F, 2000) |
| "The transition from compensated left ventricular hypertrophy (LVH) to heart failure is associated with alterations in the myocardial interstitium." | 1.31 | Reduction in myocardial collagen cross-linking parallels left ventricular dilatation in rat models of systolic chamber dysfunction. ( Chung, ES; Lancaster, EJ; Mela, T; Meyer, TE; Norton, GR; Sprott, S; Tsotetsi, OJ; Woodiwiss, AJ, 2001) |
| "V-O cardiac hypertrophy was induced in rabbits by the formation of an arterio-venous shunt between the carotid artery and jugular vein 12 to 15 weeks after the operation." | 1.31 | Differential alteration of cardiotonic effects of EMD 57033 and beta-adrenoceptor agonists in volume-overload rabbit ventricular myocytes. ( Atsumi, H; Endoh, M; Nakada, S; Sakurai, K; Sugawara, H; Tomoike, H, 2000) |
| "The isoproterenol group had a lower global critical oxygen delivery than the other groups (8." | 1.31 | Effects of alpha - and beta -adrenergic stimulation on hepatosplanchnic perfusion and oxygen extraction in endotoxic shock. ( Cherkaoui, S; De Backer, D; De Jongh, R; Vincent, JL; Vray, B; Zhang, H, 2001) |
| "Ventricular arrhythmias and contractile dysfunction are the main causes of death in human heart failure (HF)." | 1.31 | Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. ( Bers, DM; Li, L; Pogwizd, SM; Schlotthauer, K; Yuan, W, 2001) |
| "The objective of this study was to assess the structural, mechanical and electrophysiological changes associated with chronic administration of epirubicin (Pharmorubicin), which is a cardiotoxic anthracycline antibiotic used in conventional cancer chemotherapy." | 1.30 | Characterisation of a cellular model of cardiomyopathy, in the rabbit, produced by chronic administration of the anthracycline, epirubicin. ( Cameron, CH; Geraghty, RF; Kelso, EJ; McDermott, BJ; Nicholls, DP; Silke, B, 1997) |
| "Caffeine (10 mM) was used to release calcium from the SR." | 1.30 | Effects of cyclic adenosine monophosphate (cAMP) on sarcoplasmic reticulum Ca(2+)-loading in failing rabbit and human cardiac trabeculae. ( Cobbe, SM; Denvir, MA; MacFarlane, NG; Miller, DJ, 1998) |
| " Intratracheal administration of IL-1beta or chronic administration of albuterol significantly decreased (p < 0." | 1.30 | An in vivo model of beta-adrenoceptor desensitization. ( Agrawal, DK; Chong, BT; Romero, FA; Townley, RG, 1998) |
| "Regional myocardial ischemia is associated with increased levels of adenosine and norepinephrine, factors that may alter activation of the beta-adrenergic receptor (beta AR)-G protein-adenylyl cyclase pathway in the heart." | 1.29 | Regional myocardial downregulation of the inhibitory guanosine triphosphate-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model of chronic episodic myocardial ischemia. ( Hammond, HK; McKirnan, MD; Ping, P; Roth, DA, 1993) |
| "In this model of dilated cardiomyopathy: (1) relaxation is markedly prolonged; (2) the response to beta adrenergic stimulation is diminished; (3) Mg-ATPase activities and myofibrillar protein content are reduced; and (4) sympathetic activity in the heart is markedly increased with depletion of noradrenaline stores." | 1.29 | Pathophysiological and biochemical characterisation of an avian model of dilated cardiomyopathy: comparison to findings in human dilated cardiomyopathy. ( Fuleihan, F; Glass, MG; Gwathmey, JK; Hajjar, RJ; Liao, R; Young, JB, 1993) |
| " Pretreatment of muscle strips from BG dogs with isoproterenol had no effect on subsequent dose-response curves to methacholine (pD2 = 7." | 1.29 | Impaired beta-adrenergic receptor activation of adenylyl cyclase in airway smooth muscle in the basenji-greyhound dog model of airway hyperresponsiveness. ( Black, C; Curry, C; Emala, C; Hirshman, CA; Levine, MA, 1993) |
| "These findings indicate that hyperlipidemia can potentiate the cardiovascular responses to adrenergic stimulation, whereas reflex cardiovascular regulation is somewhat altered by hyperlipidemia." | 1.28 | Effect of hyperlipidemia on cardiovascular responses to adrenergic stimulation in piglets. ( Doi, K; Hirose, H; Kuwahara, M; Sugano, S, 1992) |
| "Metoprolol (6 mg." | 1.28 | Metoprolol and ventricular repolarisation and refractoriness: lack of chronic adaptational class III effects in rabbit. ( Barr, SM; Cobbe, SM; Manley, BS, 1991) |
| "In previous work, we have shown that the chronic administration of verapamil, a calcium channel blocker, ameliorated the mortality, pathology, and biochemical alterations associated with acute murine Chagas' disease." | 1.28 | Effect of verapamil on the development of chronic experimental Chagas' disease. ( Bilezikian, JP; Factor, SM; Morris, SA; Tanowitz, HB; Weiss, LM; Wittner, M, 1989) |
| "Murine trisomy 16 (Ts16) has been proposed as a model to study Down's syndrome (DS), because mouse chromosome 16 carries several genes homologous to loci on the human chromosome 21." | 1.27 | Adrenergic sensitivity of cultured murine trisomy 16 cells. ( Ozand, PT; Reed, WD, 1985) |
| "Isoproterenol responses were determined against a half-maximal methacholine contraction." | 1.27 | Comparison of drug responses in vivo and in vitro in airways of dogs with and without airway hyperresponsiveness. ( Austin, DR; Downes, H; Hirshman, CA; Parks, CM, 1986) |
| "Histamine release was significantly increased in 4 day-vaccinated animals but not 1 or 10 days after vaccination, while broncho-constriction was potentiated in 1 and in 4 day-vaccinated animals." | 1.26 | The effects of Haemophilus influenzae vaccination on anaphylactic mediator release and isoprenaline-induced inhibition of mediator release. ( Nijkamp, FP; Raaijmakers, JA; Schreurs, AJ; Terpstra, GK, 1980) |
| "The necrosis was confirmed by ECG changes, increased serum activities of AspAT, AlAT, GPT and LDH, and by histological examination." | 1.26 | A temporal profile of changes in myocardial manganese after isoprenaline induced cardiac necrosis in albino rats. ( Ahmad, M; Hasan, MZ; Jameel, SA; Kumar, S; Mathew, BM; Seth, TD, 1979) |
| " When keeping the heart rate constant by means of a pace maker, carbocromen even at higher dosage caused a clear-cut improvement." | 1.26 | [The effect of carbocromen on the ST segment of the epicardial electrocardiogram in a model of intermitting myocardial ischemia (author's transl)]. ( Kunath, B; Nitz, RE; Scholtholt, J; Sirbulescu, R, 1976) |
| "The incidence of ventricular arrhythmias was increased by aprindine (from 1 in 11 to 8 in 11 dogs), decresed by verapamil (from 3 in 7 to 0 in 7 dogs) and was not changes by quinidine or isoproterenol." | 1.26 | Effect of drugs on conduction delay and incidence of ventricular arrhythmias induced by acute coronary occlusion in dogs. ( Elharrar, V; Gaum, WE; Zipes, DP, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 158 (18.44) | 18.7374 |
| 1990's | 75 (8.75) | 18.2507 |
| 2000's | 183 (21.35) | 29.6817 |
| 2010's | 346 (40.37) | 24.3611 |
| 2020's | 95 (11.09) | 2.80 |
| Authors | Studies |
|---|---|
| Nakajima, Y | 1 |
| Imanishi, M | 1 |
| Itou, S | 1 |
| Hamashima, H | 1 |
| Tomishima, Y | 1 |
| Washizuka, K | 1 |
| Sakurai, M | 1 |
| Matsui, S | 1 |
| Imamura, E | 1 |
| Ueshima, K | 1 |
| Yamamoto, T | 2 |
| Yamamoto, N | 1 |
| Ishikawa, H | 1 |
| Nakano, K | 1 |
| Unami, N | 1 |
| Hamada, K | 1 |
| Hattori, K | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 2 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Wang, Y | 16 |
| Zhang, X | 7 |
| Fu, Y | 1 |
| Fu, D | 1 |
| Zhen, D | 1 |
| Xing, A | 1 |
| Chen, Y | 6 |
| Gong, G | 1 |
| Wei, C | 1 |
| Zhang, Y | 20 |
| Shang, Z | 1 |
| Liu, A | 1 |
| Asdaq, SMB | 1 |
| Alamri, AS | 1 |
| Alsanie, WF | 1 |
| Alhomrani, M | 1 |
| Flamant, M | 1 |
| Mougenot, N | 2 |
| Balse, E | 1 |
| Le Fèvre, L | 1 |
| Atassi, F | 1 |
| Gautier, EL | 1 |
| Le Goff, W | 1 |
| Keck, M | 1 |
| Nadaud, S | 1 |
| Combadière, C | 1 |
| Boissonnas, A | 1 |
| Pavoine, C | 1 |
| Emran, T | 1 |
| Chowdhury, NI | 1 |
| Sarker, M | 1 |
| Bepari, AK | 1 |
| Hossain, M | 1 |
| Rahman, GMS | 2 |
| Reza, HM | 2 |
| Liu, C | 2 |
| Li, B | 3 |
| Yan, Q | 1 |
| Niu, S | 1 |
| Zhao, Y | 4 |
| Xiong, C | 1 |
| Zhang, T | 2 |
| Wei, J | 1 |
| Joo, NS | 1 |
| Cho, HJ | 1 |
| Shinbashi, M | 1 |
| Choi, JY | 1 |
| Milla, CE | 1 |
| Engelhardt, JF | 1 |
| Wine, JJ | 1 |
| Cinar, I | 1 |
| Yayla, M | 1 |
| Tavaci, T | 1 |
| Toktay, E | 1 |
| Ugan, RA | 1 |
| Bayram, P | 1 |
| Halici, H | 1 |
| Li, Y | 13 |
| Zhou, WW | 1 |
| Sun, JH | 1 |
| Yang, HX | 1 |
| Xu, GR | 1 |
| Song, QH | 1 |
| Zhang, C | 3 |
| Liu, WZ | 1 |
| Liu, XC | 1 |
| Li, AY | 1 |
| Yáñez-Bisbe, L | 1 |
| Garcia-Elias, A | 1 |
| Tajes, M | 1 |
| Almendros, I | 2 |
| Rodríguez-Sinovas, A | 1 |
| Inserte, J | 2 |
| Ruiz-Meana, M | 1 |
| Farré, R | 2 |
| Farré, N | 2 |
| Benito, B | 2 |
| Liao, M | 1 |
| Xie, Q | 2 |
| Yang, C | 2 |
| Lin, C | 1 |
| Wang, G | 2 |
| Liu, B | 5 |
| Zhu, L | 2 |
| Gonçalves, MSS | 1 |
| Silva, EAP | 1 |
| Santos, DM | 1 |
| Santana, IR | 1 |
| Souza, DS | 2 |
| Araujo, AM | 1 |
| Heimfarth, L | 1 |
| Vasconcelos, CML | 1 |
| Santos, VCO | 1 |
| Santos, MRV | 1 |
| de S S Barreto, R | 1 |
| Quintans Júnior, LJ | 1 |
| Barreto, AS | 1 |
| Pan, Y | 1 |
| Gao, J | 3 |
| Gu, R | 2 |
| Song, W | 2 |
| Li, H | 11 |
| Wang, J | 14 |
| Gu, Y | 1 |
| Chen, H | 2 |
| Zhang, H | 8 |
| Uccello, TP | 1 |
| Lesch, ML | 1 |
| Ullman, NA | 1 |
| Kintzel, SA | 1 |
| Gradzewicz, LB | 1 |
| Velagaleti, T | 1 |
| Fleming, FJ | 1 |
| Mills, BN | 1 |
| Murphy, JD | 1 |
| Garrett-Larsen, J | 1 |
| Qiu, H | 2 |
| Drage, MG | 1 |
| Ye, J | 2 |
| Gavras, NW | 1 |
| Johnston, CJ | 1 |
| Love, TMT | 1 |
| Repasky, EA | 1 |
| Linehan, DC | 1 |
| Lord, EM | 1 |
| Gerber, SA | 1 |
| Liu, Z | 1 |
| Chen, X | 6 |
| Ye, T | 1 |
| Wan, W | 1 |
| Yu, Y | 1 |
| Yang, B | 2 |
| Hayashi, T | 1 |
| Tiwary, SK | 1 |
| Lim, KRQ | 1 |
| Rocha-Resende, C | 1 |
| Kovacs, A | 1 |
| Weinheimer, C | 1 |
| Mann, DL | 1 |
| Wu, W | 1 |
| Lu, Q | 2 |
| Ma, S | 1 |
| Du, JC | 1 |
| Huynh, K | 1 |
| Duong, T | 1 |
| Pang, ZD | 1 |
| Donner, D | 1 |
| Meikle, PJ | 1 |
| Deng, XL | 1 |
| Du, XJ | 1 |
| Horowitz, JD | 1 |
| Surikow, SY | 1 |
| Madias, JE | 1 |
| Aodah, AH | 1 |
| Devi, S | 1 |
| Alkholifi, FK | 1 |
| Yusufoglu, HS | 1 |
| Foudah, AI | 1 |
| Alam, A | 1 |
| Logantha, SJRJ | 1 |
| Kharche, SR | 1 |
| Atkinson, AJ | 1 |
| Hao, G | 1 |
| Boyett, MR | 1 |
| Dobrzynski, H | 1 |
| Ghazouani, L | 1 |
| Khdhiri, E | 1 |
| Elmufti, A | 1 |
| Feriani, A | 1 |
| Tir, M | 1 |
| Baaziz, I | 1 |
| Hajji, R | 2 |
| Ben Mansour, H | 1 |
| Ammar, H | 1 |
| Abid, S | 1 |
| Mnafgui, K | 3 |
| Nalban, N | 1 |
| Sangaraju, R | 1 |
| Alavala, S | 1 |
| Mir, SM | 1 |
| Jerald, MK | 1 |
| Sistla, R | 2 |
| Aa, N | 2 |
| Guo, JH | 1 |
| Cao, B | 2 |
| Sun, RB | 1 |
| Ma, XH | 1 |
| Chu, Y | 1 |
| Zhou, SP | 1 |
| Aa, JY | 1 |
| Yang, ZJ | 1 |
| Sun, H | 3 |
| Wang, GJ | 1 |
| Zheng, A | 1 |
| Yi, H | 1 |
| Li, F | 2 |
| Han, L | 1 |
| Yu, J | 2 |
| Cheng, X | 1 |
| Su, H | 2 |
| Hong, K | 2 |
| Li, J | 11 |
| Qu, C | 1 |
| Xu, DQ | 1 |
| Yue, SJ | 1 |
| Shen, LF | 1 |
| Zhou, GS | 1 |
| Chen, YY | 1 |
| Wang, XP | 1 |
| Bai, JQ | 1 |
| Liu, F | 2 |
| Tang, YP | 1 |
| Zhao, BC | 1 |
| Duan, JA | 1 |
| Che, Y | 1 |
| Shen, DF | 2 |
| Wang, ZP | 1 |
| Jin, YG | 1 |
| Wu, QQ | 1 |
| Wang, SS | 1 |
| Yuan, Y | 2 |
| Ren, S | 3 |
| Chang, S | 1 |
| Tran, A | 1 |
| Mandelli, A | 1 |
| Wang, JJ | 3 |
| Zhang, JC | 1 |
| Xia, L | 1 |
| Jiang, Y | 3 |
| Wu, DQ | 1 |
| Liu, SC | 1 |
| Zhou, XN | 1 |
| Zhang, FX | 1 |
| Tsorin, IB | 1 |
| Barchukov, VV | 1 |
| Vititnova, MB | 1 |
| Kryzhanovskii, SA | 1 |
| Seredenin, SB | 1 |
| Tu, L | 1 |
| Cheng, M | 1 |
| Sun, Y | 2 |
| Fang, Y | 1 |
| Liu, J | 5 |
| Liu, W | 3 |
| Feng, J | 4 |
| Jin, Y | 1 |
| Yang, Y | 4 |
| Ding, Z | 1 |
| Zhong, R | 1 |
| Xia, T | 1 |
| Wang, W | 4 |
| Zhao, H | 1 |
| Shu, Z | 1 |
| Wei, Y | 2 |
| Wu, Y | 2 |
| Feng, K | 2 |
| Tao, R | 1 |
| Xu, H | 3 |
| Tang, Y | 2 |
| Lillo, MA | 1 |
| Himelman, E | 1 |
| Shirokova, N | 1 |
| Xie, LH | 2 |
| Fraidenraich, D | 2 |
| Contreras, JE | 2 |
| Wang, M | 1 |
| Qian, L | 3 |
| Ming, H | 1 |
| Fang, L | 2 |
| Zhang, M | 6 |
| Xu, Y | 6 |
| Ban, Y | 1 |
| Zhang, W | 8 |
| Liu, Y | 6 |
| Wang, N | 2 |
| Ren, Q | 1 |
| Lin, P | 1 |
| Wang, Q | 3 |
| Zhang, B | 4 |
| Feng, L | 2 |
| Ouyang, F | 1 |
| Liu, X | 6 |
| Liu, G | 2 |
| He, Y | 2 |
| Hu, H | 2 |
| Jiang, P | 1 |
| Sun, L | 1 |
| Hu, Y | 3 |
| Mishra, A | 1 |
| Sreeharsha, N | 1 |
| Moktan, JB | 1 |
| Kumar, P | 2 |
| Wang, L | 9 |
| Zhao, Z | 1 |
| Liu, H | 4 |
| Guo, D | 1 |
| Guo, R | 1 |
| Liu, N | 4 |
| Zhang, J | 12 |
| Baruscotti, M | 1 |
| Zhao, L | 2 |
| Roos, KLT | 1 |
| Al-Jumaily, AM | 3 |
| Karam, S | 1 |
| Margaria, JP | 1 |
| Bourcier, A | 1 |
| Mika, D | 1 |
| Varin, A | 1 |
| Bedioune, I | 1 |
| Lindner, M | 1 |
| Bouadjel, K | 1 |
| Dessillons, M | 1 |
| Gaudin, F | 1 |
| Lefebvre, F | 1 |
| Mateo, P | 1 |
| Lechène, P | 1 |
| Gomez, S | 1 |
| Domergue, V | 1 |
| Robert, P | 1 |
| Coquard, C | 1 |
| Algalarrondo, V | 1 |
| Samuel, JL | 2 |
| Michel, JB | 1 |
| Charpentier, F | 1 |
| Ghigo, A | 1 |
| Hirsch, E | 1 |
| Fischmeister, R | 1 |
| Leroy, J | 1 |
| Vandecasteele, G | 1 |
| Xue, Y | 3 |
| Jin, W | 2 |
| Wang, H | 2 |
| Guan, S | 1 |
| Chu, X | 2 |
| Balkrishna, A | 1 |
| Rustagi, Y | 1 |
| Bhattacharya, K | 1 |
| Varshney, A | 1 |
| Alabi, B | 1 |
| Omobowale, T | 1 |
| Badejo, J | 1 |
| Adedapo, A | 1 |
| Fagbemi, O | 1 |
| Iwalewa, O | 1 |
| Ryu, B | 1 |
| Choi, SW | 1 |
| Lee, SG | 1 |
| Jeong, YH | 1 |
| Kim, U | 1 |
| Kim, J | 1 |
| Jung, CR | 1 |
| Chung, HM | 1 |
| Park, JH | 1 |
| Kim, CY | 1 |
| Liu, M | 1 |
| Du, Q | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-centre Randomized, Placebo-controlled Trial of Mirabegron, a New beta3-adrenergic Receptor Agonist on Left Ventricular Mass and Diastolic Function in Patients With Structural Heart Disease[NCT02599480] | Phase 2 | 296 participants (Actual) | Interventional | 2016-04-30 | Active, not recruiting | ||
| Scheme of Primary Prevention of Infection by COVID-19, in Workers: Phase II Controlled Clinical Trial, to be Carried Out in Medellín-Antioquia[NCT04420260] | 152 participants (Actual) | Interventional | 2021-03-18 | Completed | |||
| A Randomized Open Label Trial of Spironolactone Versus Prednisolone in Corticosteroid-naïve Boys With DMD[NCT03777319] | Phase 1 | 2 participants (Actual) | Interventional | 2018-12-05 | Terminated (stopped due to Inability to recruit participants.) | ||
| Pathogenesis of Acute Stress Induced (Tako-tsubo) Cardiomyopathy: Energy Shut-Down or Intense Inflammation? The TERRIFIC Study[NCT02897739] | 77 participants (Actual) | Observational [Patient Registry] | 2015-08-31 | Completed | |||
| Electromechanical Profiling of Arrhythmogenic Substrates and Triggers in the Long-QT Syndrome[NCT04074122] | 150 participants (Anticipated) | Observational | 2020-01-01 | Not yet recruiting | |||
| Impact of a Home-based Exercise Program on Prognostic Biomarkers in Men With Prostate Cancer[NCT03397030] | 27 participants (Actual) | Interventional | 2017-01-05 | Completed | |||
| A 3-arm Randomized Controlled Study Comparing Ultrasound-guided Cryoablation, Ultrasound-guided Perineural Lidocaine and Ultrasound-guided Perineural Saline to Treat Intermetatarsal Neuroma[NCT02838758] | Phase 1 | 10 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The determination of whether spironolactone has similar efficacy to glucocorticoids in improving muscle strength in steroid naïve DMD patients. This will be determined by measuring the time to complete a 100 meter timed test (100M). (NCT03777319)
Timeframe: 6 months
| Intervention | sec (Number) |
|---|---|
| Spironolactone | -0.6 |
| Prednisolone | -5.3 |
Secondary outcome measures will be Dynamometry score, which is a summation of maximum voluntary isometric contraction test values for knee flexion, knee extension, elbow flexion, and elbow extension (NCT03777319)
Timeframe: 6 months
| Intervention | kg (Number) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Elbow Flexion (Right)-Baseline | Elbow Flexion (Left)-Baseline | Elbow Extension (Right)-Baseline | Elbow Extension (Left)-Baseline | Knee Flexion (Right)-Baseline | Knee Flexion (Left)-Baseline | Knee Extension (Right)-Baseline | Knee Extension (Left)-Baseline | Elbow Flexion (Right)-Month 6 | Elbow Flexion (Left)-Month 6 | Elbow Extension (Right)-Month 6 | Elbow Extension (Left)-Month 6 | Knee Flexion (Right)-Month 6 | Knee Flexion (Left)-Month 6 | Knee Extension (Right)-Month 6 | Knee Extension (Left)-Month 6 | |
| Prednisolone | 3.6 | 4.1 | 5.3 | 4.1 | 3.3 | 3.4 | 4.8 | 5.2 | 2.9 | 3.4 | 4.3 | 3.8 | 4.1 | 3.9 | 6 | 5.1 |
| Spironolactone | 0 | 0 | 0 | 0 | 4.1 | 2.8 | 3.8 | 5.9 | 3.1 | 3.5 | 2.4 | 2.5 | 4.3 | 4.1 | 7.2 | 8.3 |
Electrolytes (Sodium, Potassium, Cloride and Carbon dioxide, mmol/L) will be measured on a monthly basis following initiation of either spironolactone or prednisolone. (NCT03777319)
Timeframe: 6 months
| Intervention | mmol/L (Number) | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sodium-Baseline | Sodium-Month 1 | Sodium-Month 2 | Sodium-Month 3 | Sodium-Month 4 | Sodium-Month 5 | Sodium-Month 6 | Potassium-Baseline | Potassium-Month 1 | Potassium-Month 2 | Potassium-Month 3 | Potassium-Month 4 | Potassium-Month 5 | Potassium-Month 6 | Chloride-Baseline | Chloride-Month 1 | Chloride-Month 2 | Chloride-Month 3 | Chloride-Month 4 | Chloride-Month 5 | Chloride-Month 6 | CO2-Baseline | CO2-Month 1 | CO2-Month 2 | CO2-Month 3 | CO2-Month 4 | CO2-Month 5 | CO2-Month 6 | |
| Prednisolone | 140 | 140 | 139 | 141 | 139 | 139 | 143 | 3.8 | 4 | 4.5 | 3.9 | 4.6 | 4.2 | 3.9 | 105 | 105 | 104 | 105 | 105 | 106 | 105 | 22 | 24 | 24 | 24 | 25 | 26 | 26 |
| Spironolactone | 142 | 142 | 141 | 142 | 139 | 139 | 140 | 4.5 | 4.7 | 4.2 | 4.1 | 4.5 | 4.5 | 4.3 | 103 | 109 | 107 | 103 | 103 | 103 | 101 | 29 | 22 | 25 | 27 | 28 | 28 | 26 |
10 reviews available for isoproterenol and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of myocardial hypertrophy by magnesium isoglycyrrhizinate through the TLR4/NF-κB signaling pathway in mice.
Topics: Animals; Anti-Inflammatory Agents; Atrial Natriuretic Factor; bcl-2-Associated X Protein; Creatine K | 2018 |
Morphological and functional characteristics of models of experimental myocardial injury induced by isoproterenol.
Topics: Animals; Disease Models, Animal; Heart Conduction System; Humans; Isoproterenol; Myocardial Contract | 2012 |
A novel scheme of dystrophin disruption for the progression of advanced heart failure.
Topics: Animals; Calcium-Binding Proteins; Calpain; Cardiomyopathy, Dilated; Cell Membrane Permeability; Cri | 2005 |
Influence of environmental stress on pathogenesis of sudden cardiac death.
Topics: Adenosine Triphosphate; Animals; Catecholamines; Coronary Circulation; Coronary Disease; Death, Sudd | 1977 |
Importance of receptor regulation in the pathophysiology and therapy of congestive heart failure.
Topics: Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Disease Models, Animal; Dobutamine; Dogs; | 1986 |
Psychobiology of anxiety and anxiety disorders.
Topics: Animals; Anxiety; Anxiety Disorders; Blood Platelets; Caffeine; Carbolines; Carbon Dioxide; Cats; Di | 1985 |
Autonomic imbalance in asthma with special reference to beta adrenergic blockade.
Topics: Acetylcholine; Adenylyl Cyclases; Adrenergic alpha-Antagonists; Animals; Asthma; Blood Glucose; Brad | 1972 |
Toxic agents and cardiomyopathies.
Topics: Alcoholism; Animals; Autopsy; Cardiomyopathies; Cobalt; Disease Models, Animal; Drug-Related Side Ef | 1972 |
Cerebral arterial spasm: current concepts.
Topics: Anesthesia, General; Animals; Blood Coagulation; Blood Platelets; Brain; Catecholamines; Cerebral Ar | 1974 |
Pathophysiology and therapy of the shock of myocardial infarction.
Topics: Acute Disease; Animals; Coronary Vessels; Digitalis Glycosides; Dilatation; Disease Models, Animal; | 1970 |
1 trial available for isoproterenol and Disease Models, Animal
| Article | Year |
|---|---|
Ammonia impairs neutrophil phagocytic function in liver disease.
Topics: Amino Acids; Ammonia; Animals; Cell Survival; Cells, Cultured; Disease Models, Animal; Double-Blind | 2008 |
846 other studies available for isoproterenol and Disease Models, Animal
| Article | Year |
|---|---|
Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human beta(3)-adrenergic receptor agonists: Part IV.
Topics: Adrenergic Agonists; Adrenergic beta-3 Receptor Agonists; Animals; Benzoates; Biphenyl Compounds; Co | 2008 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
1, 8-cineole protects against ISO-induced heart failure by inhibiting oxidative stress and ER stress in vitro and in vivo.
Topics: Animals; Apoptosis; Cell Line; Disease Models, Animal; Endoplasmic Reticulum Stress; Eucalyptol; Hea | 2021 |
Angiotensin-(3-7) alleviates isoprenaline-induced cardiac remodeling via attenuating cAMP-PKA and PI3K/Akt signaling pathways.
Topics: Angiotensin II; Animals; Cardiomegaly; Cardiovascular Agents; Cells, Cultured; Cyclic AMP; Cyclic AM | 2021 |
Cardioprotective Potential of Garlic Oil and Its Active Constituent, Diallyl Disulphide, in Presence of Carvedilol during Chronic Isoprenaline Injection-Mediated Myocardial Necrosis in Rats.
Topics: Allyl Compounds; Animals; Antioxidants; Cardiotonic Agents; Carvedilol; Catalase; Disease Models, An | 2021 |
Early activation of the cardiac CX3CL1/CX3CR1 axis delays β-adrenergic-induced heart failure.
Topics: Adrenergic beta-Agonists; Animals; Cell Communication; Cell Proliferation; Cells, Cultured; Chemokin | 2021 |
L-carnitine protects cardiac damage by reducing oxidative stress and inflammatory response via inhibition of tumor necrosis factor-alpha and interleukin-1beta against isoproterenol-induced myocardial infarction.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carnitine; Disease Models, Animal; Fibrosis; Inflam | 2021 |
Protective Effects and Mechanisms of Recombinant Human Glutathione Peroxidase 4 on Isoproterenol-Induced Myocardial Ischemia Injury.
Topics: Animals; Apoptosis; Biomarkers; Cell Line; Disease Models, Animal; Electrocardiography; Humans; Isop | 2021 |
Combined agonists act synergistically to increase mucociliary clearance in a cystic fibrosis airway model.
Topics: Animals; Carbachol; Colforsin; Cystic Fibrosis; Disease Models, Animal; Drug Synergism; Drug Therapy | 2021 |
In Vivo and In Vitro Cardioprotective Effect of Gossypin Against Isoproterenol-Induced Myocardial Infarction Injury.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Cardiotox | 2022 |
Modified citrus pectin prevents isoproterenol-induced cardiac hypertrophy associated with p38 signalling and TLR4/JAK/STAT3 pathway.
Topics: Animals; Atrial Natriuretic Factor; Cardiomegaly; Cardiovascular Agents; Disease Models, Animal; Gal | 2021 |
Aging Impairs Reverse Remodeling and Recovery of Ventricular Function after Isoproterenol-Induced Cardiomyopathy.
Topics: Aging; Animals; Cardiomyopathies; Collagen; Disease Models, Animal; Female; Fibrosis; Gene Expressio | 2021 |
Main active components of Si-Miao-Yong-An decoction (SMYAD) attenuate autophagy and apoptosis via the PDE5A-AKT and TLR4-NOX4 pathways in isoproterenol (ISO)-induced heart failure models.
Topics: Animals; Apoptosis; Autophagy; Cell Line; Cell Survival; Chlorogenic Acid; Coumaric Acids; Cyclic Nu | 2022 |
Nerolidol attenuates isoproterenol-induced acute myocardial infarction in rats.
Topics: Animals; Antioxidants; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; | 2022 |
Effect of injection of different doses of isoproterenol on the hearts of mice.
Topics: Animals; Disease Models, Animal; Heart; Heart Failure; Humans; Isoproterenol; Mice; Mice, Inbred C57 | 2022 |
Radiation Therapy Exacerbates Tumor-Promoting Innervation and Nerve Signaling in Rectal Cancer.
Topics: Animals; Disease Models, Animal; Humans; Isoproterenol; Mice; Mice, Inbred C57BL; Propranolol; Recta | 2023 |
Pinocembrin alleviates the susceptibility to atrial fibrillation in isoproterenol-induced rats.
Topics: Animals; Atrial Fibrillation; Atrial Remodeling; Caspase 1; Collagen Type I; Connexins; Disease Mode | 2022 |
Refining the reproducibility of a murine model of stress-induced reversible cardiomyopathy.
Topics: Animals; Cardiomyopathies; Disease Models, Animal; Female; Humans; Isoproterenol; Mice; Mice, Inbred | 2023 |
Mitochondrial damage in a Takotsubo syndrome-like mouse model mediated by activation of β-adrenoceptor-Hippo signaling pathway.
Topics: Animals; Disease Models, Animal; Female; Hippo Signaling Pathway; Isoproterenol; Mice; Reactive Oxyg | 2023 |
Understanding Takotsubo syndrome: first evaluate your mouse model.
Topics: Animals; Disease Models, Animal; Isoproterenol; Mice; Reproducibility of Results; Takotsubo Cardiomy | 2023 |
Further refining of the murine model of intraperitoneal injection of isoproterenol-induced takotsubo syndrome.
Topics: Animals; Disease Models, Animal; Humans; Injections, Intraperitoneal; Isoproterenol; Mice; Takotsubo | 2023 |
Effects of Taraxerol on Oxidative and Inflammatory Mediators in Isoproterenol-Induced Cardiotoxicity in an Animal Model.
Topics: Animals; Antioxidants; Cardiotoxicity; Disease Models, Animal; Inflammation Mediators; Isoproterenol | 2023 |
Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring.
Topics: Action Potentials; Animals; Atrioventricular Node; Calcium Signaling; Carbachol; Cardiac Electrophys | 2019 |
Cardioprotective effects of (
Topics: Animals; Benzopyrans; Biomarkers; Cardiotonic Agents; Coumarins; Disease Models, Animal; Electrocard | 2019 |
Arbutin Attenuates Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting TLR-4/NF-κB Pathway in Mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arbutin; Atrial Natriuretic Factor; Cardiomegaly; C | 2020 |
Compound danshen dripping pills normalize a reprogrammed metabolism of myocardial ischemia rats to interpret its time-dependent efficacy in clinic trials: a metabolomic study.
Topics: Animals; Camphanes; Cohort Studies; Disease Models, Animal; Drugs, Chinese Herbal; Female; Isoproter | 2019 |
Changes in Gut Microbiome Structure and Function of Rats with Isoproterenol-Induced Heart Failure.
Topics: Animals; Bacteria; Disease Models, Animal; Echocardiography; Gastrointestinal Microbiome; Heart Fail | 2019 |
Pharmacodynamics and pharmacokinetics of Danshen in isoproterenol-induced acute myocardial ischemic injury combined with Honghua.
Topics: Administration, Oral; Animals; Carthamus tinctorius; China; Disease Models, Animal; Drug Combination | 2020 |
Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats.
Topics: Animals; Berberine; Cardiomyopathies; Cell Transdifferentiation; Cells, Cultured; Coculture Techniqu | 2019 |
Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice.
Topics: Adrenergic beta-Agonists; Anesthesia; Animals; Disease Models, Animal; Echocardiography; Heart Failu | 2019 |
Effect of lncRNA GAS5 on rats with acute myocardial infarction through regulating miR-21.
Topics: Acute Disease; Animals; Disease Models, Animal; Injections, Subcutaneous; Isoproterenol; MicroRNAs; | 2019 |
Anti-Ischemic Activity of Fabomotizole Hydrochloride under Conditions of Endothelial Dysfunction.
Topics: Animals; Animals, Outbred Strains; Benzimidazoles; Cardiotonic Agents; Disease Models, Animal; Endoc | 2019 |
Fabrication of ultra-small nanocrystals by formation of hydrogen bonds: In vitro and in vivo evaluation.
Topics: Animals; Biological Availability; Caco-2 Cells; Cardiovascular Agents; Diffusion; Disease Models, An | 2020 |
Cardioprotective effects of a Fructus Aurantii polysaccharide in isoproterenol-induced myocardial ischemic rats.
Topics: Adrenergic beta-Agonists; Animals; Antioxidants; Cardiotonic Agents; Citrus; Disease Models, Animal; | 2020 |
Astragaloside IV inhibits cardiac fibrosis via miR-135a-TRPM7-TGF-β/Smads pathway.
Topics: Animals; Animals, Newborn; Astragalus Plant; Cardiomyopathy, Hypertrophic; Cells, Cultured; Disease | 2020 |
S-nitrosylation of connexin43 hemichannels elicits cardiac stress-induced arrhythmias in Duchenne muscular dystrophy mice.
Topics: Adrenergic beta-Agonists; Animals; Arrhythmias, Cardiac; Cell Membrane; Cell Membrane Permeability; | 2019 |
GHSR deficiency exacerbates cardiac fibrosis: role in macrophage inflammasome activation and myofibroblast differentiation.
Topics: Animals; Cardiomyopathies; Cell Transdifferentiation; Cells, Cultured; Disease Models, Animal; Extra | 2020 |
Chronic peripheral ghrelin injection exerts antifibrotic effects by increasing growth differentiation factor 15 in rat hearts with myocardial fibrosis induced by isoproterenol.
Topics: Adrenergic beta-Agonists; Animals; Cardiomyopathies; Disease Models, Animal; Fibrosis; Ghrelin; Grow | 2020 |
Long non-coding RNA RNF7 promotes the cardiac fibrosis in rat model via miR-543/THBS1 axis and TGFβ1 activation.
Topics: Animals; Biomarkers; Biopsy; Cardiomyopathies; Disease Models, Animal; Disease Susceptibility; Extra | 2020 |
Protective role of poly(lactic-co-glycolic) acid nanoparticle loaded with resveratrol against isoproterenol-induced myocardial infarction.
Topics: Animals; Antioxidants; Biocompatible Materials; Cardiotonic Agents; Disease Models, Animal; Isoprote | 2020 |
Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways.
Topics: Amides; Angiotensin II; Animals; Apoptosis; Blotting, Western; Cardiomegaly; Disease Models, Animal; | 2020 |
High content screening identifies licoisoflavone A as a bioactive compound of Tongmaiyangxin Pills to restrain cardiomyocyte hypertrophy via activating Sirt3.
Topics: Acetylation; Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Drug Ev | 2020 |
Effects of superimposed pressure oscillations on a chronic sensitized airways mouse model.
Topics: Acetylcholine; Allergens; Animals; Antigens, Plant; Aspergillus; Asthma; Biomechanical Phenomena; Br | 2020 |
Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure.
Topics: Adrenergic beta-Agonists; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease | 2020 |
Safranal, an active constituent of saffron, ameliorates myocardial ischemia via reduction of oxidative stress and regulation of Ca
Topics: Animals; Calcium; Cardiotonic Agents; Cells, Cultured; Crocus; Cyclohexenes; Disease Models, Animal; | 2020 |
Application of Zebrafish Model in the Suppression of Drug-Induced Cardiac Hypertrophy by Traditional Indian Medicine Yogendra Ras.
Topics: Animals; Antioxidants; Biomarkers; C-Reactive Protein; Cardiomegaly; Disease Models, Animal; Erythro | 2020 |
Protective effects and chemical composition of Corchorus olitorius leaf fractions against isoproterenol-induced myocardial injury through p65NFkB-dependent anti-apoptotic pathway in rats.
Topics: Animals; Apoptosis; Cardiotonic Agents; Corchorus; Disease Models, Animal; Dose-Response Relationshi | 2020 |
Development and evaluation of next-generation cardiotoxicity assay based on embryonic stem cell-derived cardiomyocytes.
Topics: Animals; Cardiotoxicity; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Doxorubicin; | 2020 |
Paeoniflorin Attenuates Myocardial Fibrosis in Isoprenaline-induced Chronic Heart Failure Rats via Inhibiting P38 MAPK Pathway.
Topics: Animals; Cardiomyopathies; Disease Models, Animal; Down-Regulation; Fibrosis; Gene Expression Regula | 2020 |
Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Carboxypeptidases A; Cardiomegaly; Case-Contr | 2020 |
Ergosterol Attenuates Isoproterenol-Induced Myocardial Cardiotoxicity.
Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Cardiotoxicity; Cell Line; Disease | 2020 |
Beneficial effects of benfotiamine, a NADPH oxidase inhibitor, in isoproterenol-induced myocardial infarction in rats.
Topics: Animals; Biomarkers; Cardiotoxins; Disease Models, Animal; Electrocardiography; Enzyme Inhibitors; H | 2020 |
Alterations of medial prefrontal cortex bioelectrical activity in experimental model of isoprenaline-induced myocardial infarction.
Topics: Animals; Brain Waves; Disease Models, Animal; Electrocardiography; Electrocorticography; Electroence | 2020 |
Manipulation of beta-adrenergic receptor in pressure-overloaded murine hearts mimics adverse and reverse cardiac remodeling.
Topics: Adrenergic beta-Agonists; Animals; Disease Models, Animal; Heart; Heart Failure; Isoproterenol; Mice | 2020 |
Effect of Gonadectomy and Angiotensin II Receptor Blockade in a Mouse Model of Isoproterenol-induced Cardiac Diastolic Dysfunction.
Topics: Angiotensin Receptor Antagonists; Animals; Cardiomegaly; Castration; Diastole; Disease Models, Anima | 2021 |
Effects of β-Adrenergic Blockade on Metabolic and Inflammatory Responses in a Rat Model of Ischemic Stroke.
Topics: Adrenergic beta-Antagonists; Animals; Brain Injuries; Cell Line; Cytokines; Disease Models, Animal; | 2020 |
Investigation on protective effect of Terminalia bellirica (Roxb.) against drugs induced cardiotoxicity in wistar albino rats.
Topics: Animals; Biomarkers; Cardiomyopathies; Cardiotoxicity; Disease Models, Animal; Doxorubicin; Fruit; I | 2020 |
Noninvasive assessment of autonomic modulation of heart rate variability in the Ts65Dn mouse model of Down syndrome: A proof of principle study.
Topics: Adrenergic beta-Agonists; Animals; Autonomic Nervous System; Carbachol; Cholinergic Agonists; Diseas | 2020 |
Preparation of Ginkgolide Solid Dispersions with Low-Molecular-Weight Chitosan and Assessment of their Protective Effect on Isoproterenol- Induced Myocardial Injury.
Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Cardiotonic Agents; Chitos | 2020 |
Interleukin-9 Aggravates Isoproterenol-Induced Heart Failure by Activating Signal Transducer and Activator of Transcription 3 Signalling.
Topics: Animals; Animals, Newborn; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Hear | 2020 |
Lack of sexual dimorphism in a mouse model of isoproterenol-induced cardiac dysfunction.
Topics: Animals; Biomarkers; Cardiomegaly; Disease Models, Animal; Echocardiography; Female; Heart Diseases; | 2020 |
The Protective Effects of Compound 21 and Valsartan in Isoproterenol-Induced Myocardial Injury in Rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Drug Therapy, Combination; | 2021 |
The conventional isoproterenol-induced heart failure model does not consistently mimic the diaphragmatic dysfunction observed in patients.
Topics: Adrenergic beta-Agonists; Animals; Diaphragm; Disease Models, Animal; Heart Failure; Humans; Isoprot | 2020 |
Protective Effects of Allicin on ISO-Induced Rat Model of Myocardial Infarction via JNK Signaling Pathway.
Topics: Animals; Antioxidants; Apoptosis; Disease Models, Animal; Disulfides; Isoproterenol; JNK Mitogen-Act | 2020 |
Novel thiazole-pyrazolone hybrids as potent ACE inhibitors and their cardioprotective effect on isoproterenol-induced myocardial infarction.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Apoptosis; Apoptosis Regulatory Proteins; Cytokin | 2020 |
Deletion of Microfibrillar-Associated Protein 4 Attenuates Left Ventricular Remodeling and Dysfunction in Heart Failure.
Topics: Adrenergic beta-Agonists; Animals; Aorta; Biomechanical Phenomena; Cardiomegaly; Carrier Proteins; C | 2020 |
Beneficial effect of sodium thiosulfate extends beyond myocardial tissue in isoproterenol model of infarction: Implication for nootropic effects.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Heart; Hydrogen Sulfide; Isoproterenol; Male; Mit | 2020 |
Canagliflozin attenuates isoprenaline-induced cardiac oxidative stress by stimulating multiple antioxidant and anti-inflammatory signaling pathways.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Canagliflozin; Disease Models, Animal; H | 2020 |
Canagliflozin ameliorates renal oxidative stress and inflammation by stimulating AMPK-Akt-eNOS pathway in the isoprenaline-induced oxidative stress model.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Antioxidants; Canagliflozin; Cells | 2020 |
Regenerative Potential of a Suspension and Spheroids of Multipotent Mesenchymal Stromal Cells from Human Umbilical Cord on the Model of Myocardial Infarction in Rats.
Topics: Animals; Disease Models, Animal; Endomyocardial Fibrosis; Heart Ventricles; Humans; Isoproterenol; M | 2020 |
Ameliorative effect of ferruginol on isoprenaline hydrochloride-induced myocardial infarction in rats.
Topics: Abietanes; Animals; Antioxidants; Biomarkers; Catalase; Disease Models, Animal; Glutathione Peroxida | 2021 |
Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy.
Topics: Albuminuria; Animals; C-Peptide; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Diabeti | 2020 |
The cardioprotective effects of the new crystal form of puerarin in isoproterenol-induced myocardial ischemia rats based on metabolomics.
Topics: Animals; Cardiotonic Agents; Crystallization; Disease Models, Animal; Heart; Humans; Isoflavones; Is | 2020 |
Ivabradine improves survival and attenuates cardiac remodeling in isoproterenol-induced myocardial injury.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Heart Failure; Isoproterenol; Ivabradine; Male; | 2021 |
Role of β
Topics: Acetanilides; Adrenergic beta-1 Receptor Agonists; Adrenergic beta-3 Receptor Agonists; Adrenergic b | 2020 |
Xanthohumol attenuates isoprenaline-induced cardiac hypertrophy and fibrosis through regulating PTEN/AKT/mTOR pathway.
Topics: Animals; Disease Models, Animal; Fibrosis; Flavonoids; Hypertrophy, Left Ventricular; Isoproterenol; | 2021 |
Inhibition of ATGL in adipose tissue ameliorates isoproterenol-induced cardiac remodeling by reducing adipose tissue inflammation.
Topics: Adipose Tissue, White; Animals; Anti-Inflammatory Agents; Cells, Cultured; Disease Models, Animal; E | 2021 |
Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart.
Topics: Adaptive Immunity; Adoptive Transfer; Animals; Dendritic Cells; Disease Models, Animal; Female; Fibr | 2021 |
MBNL1 regulates isoproterenol-induced myocardial remodelling in vitro and in vivo.
Topics: 3' Untranslated Regions; Animals; Animals, Newborn; Apoptosis; Base Sequence; Cardiomegaly; Disease | 2021 |
Chronic cannabidiol treatment reduces the carbachol-induced coronary constriction and left ventricular cardiomyocyte width of the isolated hypertensive rat heart.
Topics: Adrenergic beta-Agonists; Animals; Antihypertensive Agents; Cannabidiol; Carbachol; Cell Size; Coron | 2021 |
Therapeutic effects of medicinal plants on isoproterenol-induced heart failure in rats.
Topics: Animals; Apium; Berberis; Disease Models, Animal; Echocardiography; Garlic; Heart Failure; Humans; I | 2021 |
Calycosin reduces infarct size, oxidative stress and preserve heart function in isoproterenol-induced myocardial infarction model.
Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Cardiovascular Agents; Disease Mode | 2020 |
Two-hit mechanism of cardiac arrhythmias in diabetic hyperglycaemia: reduced repolarization reserve, neurohormonal stimulation, and heart failure exacerbate susceptibility.
Topics: Action Potentials; Angiotensin II; Animals; Arrhythmias, Cardiac; Blood Glucose; Calcium Signaling; | 2021 |
Pinoresinol diglucoside (PDG) attenuates cardiac hypertrophy via AKT/mTOR/NF-κB signaling in pressure overload-induced rats.
Topics: Animals; Animals, Newborn; Aorta, Abdominal; Cardiomegaly; Constriction, Pathologic; Disease Models, | 2021 |
Gαi-biased apelin analog protects against isoproterenol-induced myocardial dysfunction in rats.
Topics: Adenylyl Cyclases; Animals; Apelin; Apelin Receptors; Calcium-Binding Proteins; Cells, Cultured; Cyc | 2021 |
α7-nAChRs-mediated therapeutic angiogenesis accounts for the advantageous effect of low nicotine doses against myocardial infarction in rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Angiogenesis Inducing Agents; Animals; Disease Models, Anim | 2021 |
Alleviation of isoprenaline hydrochloride induced myocardial ischemia injury by brucine through the inhibition of Na+/K+-ATPase.
Topics: Animals; Disease Models, Animal; Isoproterenol; Myocardium; Rats; Strychnine | 2021 |
Origanum majorana L. Extract Protects Against Isoproterenol-Induced Cardiotoxicity in Rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Cardiotoxicity; Disease Models, Animal; | 2021 |
Huoxin Pill inhibits isoproterenol-induced transdifferentiation and collagen synthesis in cardiac fibroblasts through the TGF-β/Smads pathway.
Topics: Animals; Cardiotonic Agents; Cell Differentiation; Cell Movement; Cell Proliferation; Cell Survival; | 2021 |
Time-dependent influence of infliximab on hemodynamic responses and cardiac injuries of isoproterenol-induced myocardial infarction in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Body Weight; Disease Models, Animal; Heart Injuries | 2021 |
Cardiac Fibroblasts Mediate a Sexually Dimorphic Fibrotic Response to β-Adrenergic Stimulation.
Topics: Adrenergic beta-Agonists; Animals; Disease Models, Animal; Disease Progression; Female; Fibroblasts; | 2021 |
Andrographolide protects against isoproterenol-induced myocardial infarction in rats through inhibition of L-type Ca
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cardiotonic Agents; | 2021 |
Rosuvastatin and low-dose carvedilol combination protects against isoprenaline-induced myocardial infarction in rats: Role of PI3K/Akt/Nrf2/HO-1 signalling.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Anticholesteremic Agents; Apoptosis; | 2021 |
Inhibition of double stranded RNA dependent protein kinase (PKR) abrogates isoproterenol induced myocardial ischemia in vitro in cultured cardiomyocytes and in vivo in wistar rats.
Topics: Animals; Cell Line; Disease Models, Animal; eIF-2 Kinase; Fibrosis; Heart; Humans; Isoproterenol; Ma | 2021 |
Quercetin prevents isoprenaline-induced myocardial fibrosis by promoting autophagy via regulating miR-223-3p/FOXO3.
Topics: Animals; Atrial Fibrillation; Atrial Remodeling; Autophagy; Autophagy-Related Proteins; Case-Control | 2021 |
Cardioprotective effect of nicorandil on isoproterenol induced cardiomyopathy in the Mdx mouse model.
Topics: Animals; Cardiomyopathies; Disease Models, Animal; Female; Fibrosis; Isoproterenol; Mice, Inbred mdx | 2021 |
Evolution of β-catenin-independent Wnt-GSK3-mTOR signalling in regulation of energy metabolism in isoproterenol-induced cardiotoxicity model.
Topics: Adrenergic beta-Agonists; Animals; beta Catenin; Cardiotoxicity; Disease Models, Animal; Energy Meta | 2021 |
Betalain exerts cardioprotective and anti-inflammatory effects against the experimental model of heart failure.
Topics: Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents; Antioxidants; Betalains; Biomarkers; Ca | 2021 |
Liver X Receptor Agonist AZ876 Induces Beneficial Endogenous Cardiac Lipid Reprogramming and Protects Against Isoproterenol-Induced Cardiac Damage.
Topics: Aniline Compounds; Animals; Cellular Reprogramming; Disease Models, Animal; Fatty Acids; Fibrosis; H | 2021 |
Compound Danshen Dripping Pill inhibits doxorubicin or isoproterenol-induced cardiotoxicity.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Camphanes; Cardiotoxicity; Cell Line; Di | 2021 |
Discrete sites of frequent premature ventricular complexes cluster within the infarct border zone and coincide with high frequency of delayed afterdepolarizations under adrenergic stimulation.
Topics: Animals; Disease Models, Animal; Epicardial Mapping; Isoproterenol; Magnetic Resonance Imaging, Cine | 2021 |
Immune cell β
Topics: Adoptive Transfer; Animals; Bone Marrow Transplantation; Cell Death; Cell Proliferation; Cells, Cult | 2021 |
Lutein exerts its cardioprotective effect against the experimental model of isoprenaline-induced myocardial infarction via MIAT/miR-200a/Nrf2/TXINP pathway.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Isoproterenol; Lutein; MicroRNAs; Myocardial In | 2021 |
Cimicifugamide from Cimicifuga rhizomes functions as a nonselective β-AR agonist for cardiac and sudorific effects.
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Cell Line; CHO Cells; Cimicifuga; Cricetulus; Disease | 2017 |
Chronic inhibition of fatty acid amide hydrolase by URB597 produces differential effects on cardiac performance in normotensive and hypertensive rats.
Topics: Amidohydrolases; Animals; Antihypertensive Agents; Benzamides; Blood Pressure; Carbamates; Cyclohexa | 2017 |
Protective Role of N-Acetylcysteine on Isoprenaline-Induced Myocardial Injury: Histological, Immunohistochemical and Morphometric Study.
Topics: Acetylcysteine; Actins; Animals; Collagen; Cytoprotection; Disease Models, Animal; Immunohistochemis | 2018 |
β
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Blood Pressure; Diabetes Mellitus, Experimental; Dia | 2017 |
Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Disease Models, Animal; Echocardiography; Heart; Heart D | 2017 |
Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway.
Topics: Animals; Casein Kinases; Cyclooxygenase 2; Diethylcarbamazine; Disease Models, Animal; I-kappa B Pro | 2017 |
Cardiopreventive effect of ethanolic extract of Date Palm Pollen against isoproterenol induced myocardial infarction in rats through the inhibition of the angiotensin-converting enzyme.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Biomarkers; Cardiotonic Agents; Disease Models, A | 2017 |
Cardiaprotective effect of crocetin by attenuating apoptosis in isoproterenol induced myocardial infarction rat model.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Biomarkers; Cardiotonic Agents; Carotenoids; Caspase | 2017 |
Cardioprotective effect of nesfatin-1 against isoproterenol-induced myocardial infarction in rats: Role of the Akt/GSK-3β pathway.
Topics: Animals; Apoptosis; Calcium-Binding Proteins; Cardiotonic Agents; Disease Models, Animal; DNA-Bindin | 2017 |
Protective effects of ethanolic peel and pulp extracts of Citrus macroptera fruit against isoproterenol-induced myocardial infarction in rats.
Topics: Animals; Antioxidants; Cardiotonic Agents; Citrus; Disease Models, Animal; Fruit; Isoproterenol; Mal | 2017 |
G3BP2 is involved in isoproterenol-induced cardiac hypertrophy through activating the NF-κB signaling pathway.
Topics: Animals; Cardiomegaly; Cell Nucleus; Disease Models, Animal; Gene Knockdown Techniques; GTP-Binding | 2018 |
Diosmin Prevents Isoproterenol-Induced Heart Mitochondrial Oxidative Stress in Rats.
Topics: Animals; Antioxidants; Biomarkers; Calcium Signaling; Cardiotoxicity; Cytoprotection; Diosmin; Disea | 2018 |
Renal sympathetic denervation alleviates myocardial fibrosis following isoproterenol-induced heart failure.
Topics: Animals; Biomarkers; Connective Tissue Growth Factor; Disease Models, Animal; Echocardiography; Fibr | 2017 |
The Effects of Periostin in a Rat Model of Isoproterenol: Mediated Cardiotoxicity.
Topics: Animals; Apoptosis; Cardiotoxicity; Cell Adhesion Molecules; Cell Proliferation; Cytoprotection; Dis | 2018 |
Histological and immunohistochemical study of cardiac telocytes in a rat model of isoproterenol-induced myocardial infarction with a reference to the effect of grape seed extract.
Topics: Animals; Antioxidants; Disease Models, Animal; Grape Seed Extract; Heart Ventricles; Immunohistochem | 2017 |
Oligomeric proanthocyanidins protect myocardium by mitigating left ventricular remodeling in isoproterenol-induced postmyocardial infarction.
Topics: Animals; Antioxidants; Bone Morphogenetic Protein 4; Cardiovascular Agents; Collagen; Disease Models | 2018 |
Novel Mesenchymal Stem Cell Strategy in Alleviating Toll-Like Receptor-4, p53 and Nrf2 Signaling in Isoproterenol-Induced Myocardial Infarction in Rat Model.
Topics: Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Isoproterenol; Male; Mesenchymal Stem C | 2018 |
Protective effect of diltiazem on myocardial ischemic rats induced by isoproterenol.
Topics: Animals; Calcium; Cardiotonic Agents; Connexin 43; Diltiazem; Disease Models, Animal; Isoproterenol; | 2018 |
ClC-3 chloride channel is involved in isoprenaline-induced cardiac hypertrophy.
Topics: Animals; Animals, Newborn; Cardiomegaly; Cell Line; Chloride Channels; Dependovirus; Disease Models, | 2018 |
Proinflammatory Cytokines Are Soluble Mediators Linked with Ventricular Arrhythmias and Contractile Dysfunction in a Rat Model of Metabolic Syndrome.
Topics: Adrenergic beta-Agonists; Animals; Arrhythmias, Cardiac; Cells, Cultured; Cytokines; Disease Models, | 2017 |
Cardioprotective Mechanisms of Exenatide in Isoprenaline-induced Myocardial Infarction: Novel Effects on Myocardial α-Estrogen Receptor Expression and IGF-1/IGF-2 System.
Topics: Animals; Apoptosis; Cytoprotection; Disease Models, Animal; Estradiol; Estrogen Receptor alpha; Exen | 2018 |
β-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56δ at S573.
Topics: Adenoviridae; Adrenergic beta-Agonists; Amino Acid Sequence; Animals; Cardiomegaly; Disease Models, | 2018 |
Effect of Kaempferol Pretreatment on Myocardial Injury in Rats.
Topics: Animals; Antioxidants; Biomarkers; Cytoprotection; Disease Models, Animal; Dose-Response Relationshi | 2018 |
miR-21-5p as a potential biomarker of inflammatory infiltration in the heart upon acute drug-induced cardiac injury in rats.
Topics: Allylamine; Animals; Cardiotoxicity; Disease Models, Animal; Gene Expression Profiling; Gene Express | 2018 |
Imaging of isoproterenol-induced myocardial injury with
Topics: Animals; Biological Transport; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; | 2018 |
Cardioprotective Role of Myeloid-Derived Suppressor Cells in Heart Failure.
Topics: Aged; Animals; Cell Proliferation; Cells, Cultured; Coculture Techniques; Cytokines; Disease Models, | 2018 |
A Strategy for Optimizing the Combination of Active Components Based on Chinese Medicinal Formula Sheng-Mai-San for Myocardial Ischemia.
Topics: Animals; Creatine Kinase, MB Form; Cyclooctanes; Disease Models, Animal; Drug Combinations; Drugs, C | 2018 |
Analyzing gene expression profiles with preliminary validations in cardiac hypertrophy induced by pressure overload.
Topics: Animals; Cardiomegaly; Databases, Genetic; Disease Models, Animal; Gene Expression Profiling; Gene E | 2018 |
A simple blood microdialysis in freely-moving rats for pharmacokinetic-pharmacodynamic modeling study of Shengmai injection with simultaneous determination of drug concentrations and efficacy levels in dialysate.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Dialysis Solutions; Disease Models, Anima | 2018 |
INCREASED OXIDATIVE STRESS AND DOWN REGULATION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE (ENOS) IN THE KIDNEY ATTEN- UATE THE RESPONSIVENESS OF (XlB ADRENERGIC RECEPTORS IN THE KIDNEY OF RATS WITH LEFT VENTRICULAR HYPERTROPHY.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Caffeine; Disease Models, Animal; Dose-Response Relat | 2017 |
Cardioprotective and Anti-Aggregatory Effects of Levosimendan on Isoproterenol-Induced Myocardial Injury in High-Fat-Fed Rats Involves Modulation of PI3K/Akt/mTOR Signaling Pathway and Inhibition of Apoptosis: Comparison to Cilostazol.
Topics: Animals; Apoptosis; Cilostazol; Diet, High-Fat; Disease Models, Animal; Heart Rate; Inflammation Med | 2018 |
Cardioprotective effect of Amaranthus tricolor extract in isoprenaline induced myocardial damage in ovariectomized rats.
Topics: Amaranthus; Animals; Cardiotonic Agents; Disease Models, Animal; Female; Isoproterenol; Myocardial I | 2018 |
Effect of LCZ696, a dual angiotensin receptor neprilysin inhibitor, on isoproterenol-induced cardiac hypertrophy, fibrosis, and hemodynamic change in rats.
Topics: Aminobutyrates; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Disease Models, Anima | 2019 |
Catalpol pretreatment attenuates cardiac dysfunction following myocardial infarction in rats.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Drugs, Chinese Herbal; Iridoid Glucosides; Isop | 2018 |
Does prolonged severe hypercapnia interfere with normal cerebrovascular function in piglets?
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Animals, Newborn; Arter | 2018 |
Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome.
Topics: Animals; Cardiovascular Diseases; Cells, Cultured; Disease Models, Animal; Drugs, Chinese Herbal; Fi | 2018 |
Cyanobacteria as Nanogold Factories: Chemical and Anti-Myocardial Infarction Properties of Gold Nanoparticles Synthesized by
Topics: Animals; Antioxidants; Aquatic Organisms; Biomarkers; Biotechnology; Blood Pressure; Cardiotonic Age | 2018 |
Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis.
Topics: Animals; Cardiomyopathies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Fibr | 2018 |
[Establishment of cardiac remodeling model in FVB/N mice by intraperitoneal injection of isoproterenol].
Topics: Animals; Atrial Remodeling; Cardiovascular Diseases; Collagen; Disease Models, Animal; Humans; Injec | 2018 |
Isoproterenol-Induced Heart Failure Mouse Model Using Osmotic Pump Implantation.
Topics: Animals; Disease Models, Animal; Drug Delivery Systems; Echocardiography; Female; Heart Failure; Iso | 2018 |
A Novel Class of tRNA-Derived Small Non-Coding RNAs Respond to Myocardial Hypertrophy and Contribute to Intergenerational Inheritance.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Female; Gene Expression Profiling; Gene Regulatory Ne | 2018 |
Size dependent effects of Gold Nanoparticles in ISO-induced Hyperthyroid Rats.
Topics: Administration, Intravenous; Animals; Autophagy-Related Protein 7; Caspase 12; Cell Line; Disease Mo | 2018 |
Acute isoproterenol leads to age-dependent arrhythmogenesis in guinea pigs.
Topics: Action Potentials; Age Factors; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death, Sudden | 2018 |
Effect of ethanolic extract of Cyperus rotundus L. against isoprenaline induced cardiotoxicity.
Topics: Adrenergic beta-1 Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biomarker | 2016 |
Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β.
Topics: Adrenergic beta-Agonists; Amyloid beta-Peptides; Animals; Disease Models, Animal; Encephalitis; Envi | 2018 |
The effects of superparamagnetic iron oxide nanoparticles-labeled mesenchymal stem cells in the presence of a magnetic field on attenuation of injury after heart failure.
Topics: Animals; Disease Models, Animal; Ferric Compounds; Heart Failure; Heart Function Tests; Isoprotereno | 2018 |
Anti-fibrotic Actions of Roselle Extract in Rat Model of Myocardial Infarction.
Topics: Animals; Atrial Natriuretic Factor; Cardiovascular Agents; Collagen Type I; Collagen Type III; Disea | 2019 |
Dimethyl fumarate interferes with MyD88-dependent toll-like receptor signalling pathway in isoproterenol-induced cardiac hypertrophy model.
Topics: Animals; Cardiomegaly; Dimethyl Fumarate; Disease Models, Animal; Extracellular Signal-Regulated MAP | 2018 |
Role of type 2A phosphatase regulatory subunit B56α in regulating cardiac responses to β-adrenergic stimulation in vivo.
Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Disease Models, Animal; Dobutamine; Female; Heart R | 2019 |
Cycloastragenol ameliorates experimental heart damage in rats by promoting myocardial autophagy via inhibition of AKT1-RPS6KB1 signaling.
Topics: Animals; Astragalus propinquus; Autophagy; Cardiotonic Agents; Disease Models, Animal; Dose-Response | 2018 |
Beta-adrenergic activation induces cardiac collapse by aggravating cardiomyocyte contractile dysfunction in bupivacaine intoxication.
Topics: Anesthesia; Animals; Blood Pressure; Bupivacaine; Cardiotoxicity; Chloral Hydrate; Disease Models, A | 2018 |
Topics: Animals; Cardiomegaly; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Isoproterenol; Male; M | 2019 |
Periostin alters transcriptional profile in a rat model of isoproterenol-induced cardiotoxicity.
Topics: Animals; Cardiotoxicity; Cell Adhesion Molecules; Disease Models, Animal; Isoproterenol; Male; Rats, | 2019 |
Protective Action of Diazoxide on Isoproterenol-Induced Hypertrophy Is Mediated by Reduction in MicroRNA-132 Expression.
Topics: Animals; Animals, Newborn; Cardiomegaly; Cardiovascular Agents; Cells, Cultured; Cyclic AMP Response | 2018 |
Limited Impact of β-Adrenergic Receptor Activation on Left Ventricular Diastolic Function in Rat Models of Hypertensive Heart Disease.
Topics: Adrenergic beta-Agonists; Animals; Diastole; Disease Models, Animal; Echocardiography, Doppler, Puls | 2018 |
Limb Blood Flow Restriction Plus Mild Aerobic Exercise Training Protects the Heart Against Isoproterenol-Induced Cardiac Injury in Old Rats: Role of GSK-3β.
Topics: Age Factors; Animals; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Heart Diseases; Hindl | 2019 |
Galectin-1 attenuates cardiomyocyte hypertrophy through splice-variant specific modulation of Ca
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2019 |
The relationship between visfatin and cardiac markers on induced myocardial infarction in rats.
Topics: Animals; Biomarkers; Disease Models, Animal; Female; Heart; Isoproterenol; Myocardial Infarction; My | 2019 |
Ankyrin-B Q1283H Variant Linked to Arrhythmias Via Loss of Local Protein Phosphatase 2A Activity Causes Ryanodine Receptor Hyperphosphorylation.
Topics: Action Potentials; Animals; Ankyrins; Arrhythmias, Cardiac; Calcium; Disease Models, Animal; Electro | 2018 |
Oltipraz attenuates the progression of heart failure in rats through inhibiting oxidative stress and inflammatory response.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Cytokines; Disease Models, Animal; Fibr | 2018 |
Chronic CaMKII inhibition reverses cardiac function and cardiac reserve in HF mice.
Topics: Animals; Benzylamines; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Diseas | 2019 |
Composition and cardioprotective effects of Primula veris L. solid herbal extract in experimental chronic heart failure.
Topics: Animals; Cardiotonic Agents; Chromatography, High Pressure Liquid; Chronic Disease; Disease Models, | 2019 |
Histone deacetylase inhibition attenuates atrial arrhythmogenesis in sterile pericarditis.
Topics: Acetylcholine; Action Potentials; Animals; Atrial Fibrillation; Collagen; Disease Models, Animal; El | 2018 |
Adipocyte Death Preferentially Induces Liver Injury and Inflammation Through the Activation of Chemokine (C-C Motif) Receptor 2-Positive Macrophages and Lipolysis.
Topics: Adipocytes; Adipose Tissue; Animals; Bacteriocins; Cell Death; Disease Models, Animal; Epinephrine; | 2019 |
Phosphocreatine Attenuates Isoproterenol-Induced Cardiac Fibrosis and Cardiomyocyte Apoptosis.
Topics: Animals; Apoptosis; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Heart Diseases; Hu | 2019 |
Linagliptin Suppresses Electrical and Structural Remodeling in the Isoproterenol Induced Myocardial Injury Model.
Topics: Animals; Antioxidants; Atrial Remodeling; Cardiotonic Agents; Dipeptidyl Peptidase 4; Dipeptidyl-Pep | 2019 |
Cardioprotective Effect of Rhapontigenin in Isoproterenol-Induced Myocardial Infarction in a Rat Model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cardiotonic Agents; Disease Models, Anim | 2019 |
Contrasting Effects of Inhibition of Phosphodiesterase 3 and 5 on Cardiac Function and Interstitial Fibrosis in Rats With Isoproterenol-Induced Cardiac Dysfunction.
Topics: Animals; Arrhythmias, Cardiac; Collagen Type I; Collagen Type III; Disease Models, Animal; Fibrosis; | 2019 |
Acupuncture at PC6 prevents cardiac hypertrophy in isoproterenol-treated mice.
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Atrial Natriuretic Factor; Cardiomegaly; Disease M | 2019 |
Calpains mediate isoproterenol-induced hypertrophy through modulation of GRK2.
Topics: Animals; Calpain; Carbamates; Disease Models, Animal; G-Protein-Coupled Receptor Kinase 2; Hypertrop | 2019 |
Exchange-protein activated by cAMP (EPAC) regulates L-type calcium channel in atrial fibrillation of heart failure model.
Topics: Animals; Atrial Fibrillation; Calcium Channels, L-Type; Cells, Cultured; Disease Models, Animal; Ele | 2019 |
Transient inhibition of neddylation at neonatal stage evokes reversible cardiomyopathy and predisposes the heart to isoproterenol-induced heart failure.
Topics: Animals; Animals, Newborn; Cell Proliferation; Cells, Cultured; Cyclopentanes; Disease Models, Anima | 2019 |
In utero exposure to nicotine abolishes the postnatal response of the cardiac sodium current to isoproterenol in newborn rabbit atrium.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Animals, Newborn; Disease Models, Animal; Fema | 2019 |
Growth differentiation factor 11 is involved in isoproterenol‑induced heart failure.
Topics: Animals; Apoptosis; Biomarkers; Cells, Cultured; Disease Models, Animal; Disease Susceptibility; Gen | 2019 |
Plantamajoside attenuates isoproterenol-induced cardiac hypertrophy associated with the HDAC2 and AKT/ GSK-3β signaling pathway.
Topics: Animals; Cardiomegaly; Catechols; Cell Line; Cell Survival; Disease Models, Animal; Glucosides; Glyc | 2019 |
Comprehensive Analysis of Animal Models of Cardiovascular Disease using Multiscale X-Ray Phase Contrast Tomography.
Topics: Adrenergic beta-Agonists; Animals; Coronary Vessels; Disease Models, Animal; Heart; Heart Failure; I | 2019 |
Proinflammatory Effect of Endothelial Microparticles Is Mitochondria Mediated and Modulated Through MAPKAPK2 (MAPK-Activated Protein Kinase 2) Leading to Attenuation of Cardiac Hypertrophy.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Blotting, Western; Cardiomegaly; Cell-Derived | 2019 |
Oleic Acid Prevents Isoprenaline-Induced Cardiac Injury: Effects on Cellular Oxidative Stress, Inflammation and Histopathological Alterations.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cardiotoxicity; Disease Models, Animal; Inflammatio | 2020 |
Exercise Attenuates Acute β-Adrenergic Overactivation-Induced Cardiac Fibrosis by Modulating Cytokines.
Topics: Animals; Cytokines; Disease Models, Animal; Exercise Therapy; Fibrosis; Gene Expression Regulation; | 2019 |
2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation.
Topics: Animals; Animals, Newborn; Cardiomegaly; Disease Models, Animal; Fibroblasts; Glycogen Synthase Kina | 2019 |
Pharmacological Evaluation of the Effects of Phenylcarbamic Acid Derivatives on Cardiovascular Functions in Rats.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Carbamates; Disease Models, Animal; Electroca | 2018 |
The cardioprotective effects of icariin on the isoprenaline-induced takotsubo-like rat model: Involvement of reactive oxygen species and the TLR4/NF-κB signaling pathway.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Echocardiography; Fibrosis; Flavonoids; Humans; | 2019 |
Characterization of Myocardial Microstructure and Function in an Experimental Model of Isolated Subendocardial Damage.
Topics: Animals; Biopsy, Needle; Disease Models, Animal; Echocardiography; Endocardium; Fibrosis; Germany; H | 2019 |
HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling.
Topics: Animals; Calcium Signaling; Calcium-Binding Proteins; Cell Line; Disease Models, Animal; ELAV-Like P | 2020 |
Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats.
Topics: Administration, Oral; Animals; Arterial Pressure; Cardiotonic Agents; Disease Models, Animal; Dose-R | 2012 |
β2-Adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis.
Topics: Adrenergic beta-Agonists; Animals; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, C | 2013 |
Examining the relationship between exercise tolerance and isoproterenol-based cardiac reserve in murine models of heart failure.
Topics: Adrenergic beta-Agonists; Animals; Cardiotonic Agents; Disease Models, Animal; Exercise Test; Exerci | 2013 |
Limited recovery of pineal function after regeneration of preganglionic sympathetic axons: evidence for loss of ganglionic synaptic specificity.
Topics: Animals; Arylalkylamine N-Acetyltransferase; Autonomic Nervous System Diseases; Axons; Biophysics; B | 2013 |
MicroRNA-22 regulates cardiac hypertrophy and remodeling in response to stress.
Topics: Amino Acid Sequence; Animals; Calcineurin; Cardiomegaly; Cardiomyopathy, Dilated; Disease Models, An | 2013 |
Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress.
Topics: Animals; Calcium Signaling; Calcium-Binding Proteins; Cardiac Pacing, Artificial; Cardiomegaly; Dise | 2013 |
Tomato lycopene attenuates myocardial infarction induced by isoproterenol: electrocardiographic, biochemical and anti-apoptotic study.
Topics: Animals; Antioxidants; Apoptosis; Cardiotonic Agents; Carotenoids; Caspase 3; Disease Models, Animal | 2012 |
Catecholamine-Induced β2-adrenergic receptor activation mediates desensitization of gastric cancer cells to trastuzumab by upregulating MUC4 expression.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Catecholamines; Cell Line, Tumor; | 2013 |
Ventricular repolarization in a rat model of global heart failure.
Topics: Action Potentials; Animals; Cardiac Output; Disease Models, Animal; Electrocardiography; Female; Hea | 2013 |
Novel role for cystic fibrosis transmembrane conductance regulator in alveolar fluid clearance in lipopolysaccharide-induced acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Disease | 2013 |
A proteomic view of isoproterenol induced cardiac hypertrophy: prohibitin identified as a potential biomarker in rats.
Topics: Animals; Biomarkers; Cardiomegaly; Disease Models, Animal; Gene Expression Profiling; Gene Expressio | 2013 |
N-acetylcysteine reverses cardiac myocyte dysfunction in a rodent model of behavioral stress.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Calcium; Calcium Signaling; Cardiomyopathies; Catal | 2013 |
Screening and identifying the myocardial-injury protective ingredients from Sheng-Mai-San.
Topics: Animals; Biomarkers; Cardiovascular Agents; Chromatography, Liquid; Creatine Kinase; Cytoprotection; | 2013 |
Contrast echocardiography reveals apparently normal coronary perfusion in a rat model of stress-induced (Takotsubo) cardiomyopathy.
Topics: Animals; Contrast Media; Coronary Circulation; Disease Models, Animal; Echocardiography; Image Proce | 2014 |
Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2013 |
β-Adrenergic receptor antagonism in mice: a model for pediatric heart disease.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Child; Disease Models, Animal; Heart; Heart Disease | 2013 |
Contractile abnormalities and altered drug response in engineered heart tissue from Mybpc3-targeted knock-in mice.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Calcium Channel Blockers; Cardiomyopathy, Hypertrophic; | 2013 |
No overt structural or functional changes associated with PEG-coated gold nanoparticles accumulation with acute exposure in the mouse heart.
Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Cardiotoxins; Disease Models, Animal; Drug Delivery | 2013 |
Mouse strain determines cardiac growth potential.
Topics: Animals; Disease Models, Animal; Echocardiography; Heart; Isoproterenol; Mice; Mice, Inbred C57BL; M | 2013 |
Regulation of antioxidant system, lipids and fatty acid β-oxidation contributes to the cardioprotective effect of sodium tanshinone IIA sulphonate in isoproterenol-induced myocardial infarction in rats.
Topics: Animals; Antioxidants; Cardiotonic Agents; Disease Models, Animal; Fatty Acids; Gene Expression Regu | 2013 |
Chronic inhibition of cGMP-specific phosphodiesterase 5 suppresses endoplasmic reticulum stress in heart failure.
Topics: Animals; Aorta; Apoptosis; Calcium-Binding Proteins; Cardiomegaly; Constriction; Cyclic GMP-Dependen | 2013 |
The metabolic disturbances of isoproterenol induced myocardial infarction in rats based on a tissue targeted metabonomics.
Topics: Animals; Biomarkers; Disease Models, Animal; Isoproterenol; Male; Mass Spectrometry; Metabolic Netwo | 2013 |
Physiology and analysis of the electrocardiographic T wave in mice.
Topics: Adrenergic beta-Agonists; Animals; Calcium Channel Blockers; Chronic Disease; Disease Models, Animal | 2013 |
Cardiac-specific hexokinase 2 overexpression attenuates hypertrophy by increasing pentose phosphate pathway flux.
Topics: Adrenergic alpha-Agonists; Animals; Animals, Newborn; Cardiomegaly; Cell Death; Cells, Cultured; Deh | 2013 |
Enhanced expression of β3-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase.
Topics: Angiotensin II; Animals; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease | 2014 |
B-type natriuretic peptide and adiponectin releases in rat model of myocardial damage induced by isoproterenol administration.
Topics: Adiponectin; Animals; Biomarkers; Disease Models, Animal; Heart Injuries; Isoproterenol; Male; Myoca | 2013 |
Metabolic pathways involved in Xin-Ke-Shu protecting against myocardial infarction in rats using ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.
Topics: Administration, Oral; Animals; Biomarkers; Cardiotonic Agents; Chromatography, High Pressure Liquid; | 2014 |
Cardioprotective effect of rhizomes of Acorus gramineus against isoproterenol-induced cardiac damage in pigs.
Topics: Acorus; Animals; Antioxidants; Biomarkers; Cardiotonic Agents; Cytoprotection; Disease Models, Anima | 2014 |
Cardioprotective effect of mumie (shilajit) on experimentally induced myocardial injury.
Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Heart | 2014 |
Isoproterenol‑mediated heme oxygenase‑1 induction inhibits high mobility group box 1 protein release and protects against rat myocardial ischemia/reperfusion injury in vivo.
Topics: Adrenergic beta-Agonists; Animals; Creatine Kinase; Disease Models, Animal; Heme Oxygenase-1; Hemody | 2014 |
[Correction of isoproterenol-induced myocardial injury with magnesium salts in magnesium-deficient rats].
Topics: Animals; Aspartic Acid; Diet; Disease Models, Animal; Isoproterenol; Magnesium; Magnesium Chloride; | 2013 |
[The influence of dietary omega-3 polyunsaturated fatty acids on functional parameters of myocardial mitochondria during isoproterenol-induced heart injury].
Topics: Administration, Oral; Animals; Calcium; Disease Models, Animal; Fatty Acids, Omega-3; Isoproterenol; | 2014 |
Pentoxifylline alleviates cardiac ischemia and dysfunction following experimental angina in insulin resistance.
Topics: Adiponectin; Administration, Oral; Angina Pectoris; Animals; Diet; Disease Models, Animal; Electroca | 2014 |
Carnosic acid promotes myocardial antioxidant response and prevents isoproterenol-induced myocardial oxidative stress and apoptosis in mice.
Topics: Abietanes; Active Transport, Cell Nucleus; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Pr | 2014 |
Beneficial role of tamoxifen in experimentally induced cardiac hypertrophy.
Topics: Animals; Blood Pressure; C-Reactive Protein; Cardiomegaly; Disease Models, Animal; Female; Heart Rat | 2014 |
Can early myocardial infarction-related deaths be diagnosed using postmortem urotensin receptor expression levels?
Topics: Animals; Autopsy; Biomarkers; Disease Models, Animal; Forensic Genetics; Isoproterenol; Male; Myocar | 2014 |
Interleukin-1β blockade improves left ventricular systolic/diastolic function and restores contractility reserve in severe ischemic cardiomyopathy in the mouse.
Topics: Animals; Antibodies, Monoclonal; Disease Models, Animal; Echocardiography; Interleukin-1beta; Isopro | 2014 |
Changes in cardiac aldosterone and its synthase in rats with chronic heart failure: an intervention study of long-term treatment with recombinant human brain natriuretic peptide.
Topics: Aldosterone; Animals; Cardiotonic Agents; Chronic Disease; Collagen; Cytochrome P-450 CYP11B2; Disea | 2014 |
The effect of caffeic acid phenethyl ester on isoproterenol-induced myocardial injury in hypertensive rats.
Topics: Animals; Antioxidants; Blood Pressure; Caffeic Acids; Disease Models, Animal; Hypertension; Injectio | 2014 |
[Complex study of the rat heart at isoproterenol damage].
Topics: Adrenergic beta-Agonists; Animals; Cardiac Catheterization; Cardiography, Impedance; Disease Models, | 2014 |
The study of fetal rat model of intra-amniotic isoproterenol injection induced heart dysfunction and phenotypic switch of contractile proteins.
Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Disease Models, Animal; Female; Gene Expression Regula | 2014 |
Disruption of type 5 adenylyl cyclase prevents β-adrenergic receptor cardiomyopathy: a novel approach to β-adrenergic receptor blockade.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Apoptosis; Cardiomyopathies; Cell Size; Diseas | 2014 |
Pak1 is required to maintain ventricular Ca²⁺ homeostasis and electrophysiological stability through SERCA2a regulation in mice.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Cardiac Pacing, Artificial; Cardiomegaly; Cells, Culture | 2014 |
Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying β-adrenergic stimulation in the rat left ventricle.
Topics: Adrenergic beta-Agonists; Animals; Calcium Signaling; Computer Simulation; Disease Models, Animal; H | 2014 |
Anti-fibrosis effect of scutellarin via inhibition of endothelial-mesenchymal transition on isoprenaline-induced myocardial fibrosis in rats.
Topics: Actins; Animals; Apigenin; Basic Helix-Loop-Helix Transcription Factors; Calcium-Binding Proteins; D | 2014 |
The Huntington's disease-related cardiomyopathy prevents a hypertrophic response in the R6/2 mouse model.
Topics: Adrenergic beta-Antagonists; Animals; Brain-Derived Neurotrophic Factor; Cardiomyopathies; Collagen | 2014 |
Benidipine prevents oxidative stress, inflammatory changes and apoptosis related myofibril damage in isoproterenol-induced myocardial infarction in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Biomarkers; Cytoprotection; Dihydropyrid | 2015 |
Impaired heart rate regulation and depression of cardiac chronotropic and dromotropic function in polymicrobial sepsis.
Topics: Adrenergic beta-Agonists; Adrenergic Uptake Inhibitors; Animals; Coinfection; Disease Models, Animal | 2015 |
Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in rats.
Topics: Alkaloids; Amidohydrolases; Animals; Arginine; Cardiotonic Agents; Disease Models, Animal; Female; H | 2014 |
Tacrolimus ameliorates functional disturbances and oxidative stress in isoproterenol-induced myocardial infarction.
Topics: Administration, Cutaneous; Animals; Disease Models, Animal; Drug Administration Schedule; Electrocar | 2014 |
Reduction of isoproterenol-induced cardiac hypertrophy and modulation of myocardial connexin43 by a KATP channel agonist.
Topics: Animals; Cardiomegaly; Connexin 43; Disease Models, Animal; Gene Expression; Heart Ventricles; Immun | 2015 |
A biochemical and 2, 3, 5-triphenyl tetrazolium chloride staining study on the preventive effects of zingerone (vanillyl acetone) in experimentally induced myocardial infarcted rats.
Topics: Adenosine Triphosphatases; Animals; Biomarkers; Coloring Agents; Disease Models, Animal; Electrocard | 2015 |
Relaxant effect of superimposed length oscillation on sensitized airway smooth muscle.
Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fe | 2015 |
Gating of hippocampal output by β-adrenergic receptor activation in the pilocarpine model of epilepsy.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Disease Models, Animal; Electric Stimulation; | 2015 |
[Activation of transcription factor NF-κB in a rat model of cardiac fibrosis induced by β-adrenoceptor stimulation].
Topics: Animals; Collagen Type I; Collagen Type III; Disease Models, Animal; Fibrosis; Interleukin-6; Isopro | 2014 |
[Establishment of a FVB/N mouse model of cardiac hypertrophy by isoprenaline].
Topics: Animals; Cardiomegaly; Disease Models, Animal; Fibrosis; Isoproterenol; Mice; Mice, Inbred Strains | 2014 |
Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats.
Topics: Analysis of Variance; Animals; Biomarkers; Biopsy, Needle; Cardiotonic Agents; Cytokines; Disease Mo | 2015 |
Combined Effects of Vincristine and Quercetin in Reducing Isoproterenol-Induced Cardiac Necrosis in Rats.
Topics: Animals; Antioxidants; Biomarkers; Cardiomyopathies; Cytoprotection; Disease Models, Animal; Drug Th | 2015 |
Preventive effect of phytic acid on lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats.
Topics: Acetylglucosaminidase; Animals; Antioxidants; Cathepsin B; Cathepsin D; Cytoprotection; Disease Mode | 2015 |
Mst1 inhibition rescues β1-adrenergic cardiomyopathy by reducing myocyte necrosis and non-myocyte apoptosis rather than myocyte apoptosis.
Topics: Adrenergic beta-1 Receptor Agonists; Animals; Blotting, Western; Cardiomyopathies; Disease Models, A | 2015 |
Effects of Dantrolene Treatment on Ventricular Electrophysiology and Arrhythmogenesis in Rats With Chronic β-Adrenergic Receptor Activation.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Calcium; Cardiotonic Agents; Dantrolene; Disease M | 2015 |
SERCA-2a is involved in the right ventricular function following myocardial infarction in rats.
Topics: Animals; Disease Models, Animal; Gene Expression Regulation; Heart Failure; Isometric Contraction; I | 2015 |
Autologous c-Kit+ Mesenchymal Stem Cell Injections Provide Superior Therapeutic Benefit as Compared to c-Kit+ Cardiac-Derived Stem Cells in a Feline Model of Isoproterenol-Induced Cardiomyopathy.
Topics: Animals; Biomarkers; Cardiomyopathies; Cats; Cell Proliferation; Cells, Cultured; Disease Models, An | 2015 |
Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Agonists; Animals; Atrial Natriuretic Factor; B | 2015 |
β-Adrenergic stimulation and rapid pacing mutually promote heterogeneous electrical failure and ventricular fibrillation in the globally ischemic heart.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Cardiac Pacing, Artificial; Death, Sudden, Car | 2015 |
Nitric oxide synthase inhibition abolishes exercise-mediated protection against isoproterenol-induced cardiac hypertrophy in female mice.
Topics: Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Echocardiography; Enzyme Inhibitors; | 2015 |
Protective effects of Labisia pumila var. alata on biochemical and histopathological alterations of cardiac muscle cells in isoproterenol-induced myocardial infarction rats.
Topics: Administration, Oral; Animals; Cardiotonic Agents; Cell Membrane; Disease Models, Animal; Dose-Respo | 2015 |
l-Arginine Attenuates Cardiac Dysfunction, But Further Down-Regulates α-Myosin Heavy Chain Expression in Isoproterenol-Induced Cardiomyopathy.
Topics: Amidohydrolases; Animals; Arginine; Cardiomyopathies; Cardiotonic Agents; Disease Models, Animal; Do | 2015 |
Edaravone protects rats against oxidative stress and apoptosis in experimentally induced myocardial infarction: Biochemical and ultrastructural evidence.
Topics: Animals; Antioxidants; Antipyrine; Apoptosis; C-Reactive Protein; Caspase 3; Creatine Kinase, MB For | 2015 |
[Combined transgenic inhibition of CaMKII and Ik1 on cardiac remodeling].
Topics: Animals; Arrhythmias, Cardiac; Brugada Syndrome; Calcium-Calmodulin-Dependent Protein Kinase Type 2; | 2015 |
In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease.
Topics: Adrenergic beta-Agonists; Animals; Biosensing Techniques; Calcium-Binding Proteins; Cardiomegaly; Ce | 2015 |
Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal versus heart failure.
Topics: Angiotensin I; Animals; Bradykinin; Calcium Channels, L-Type; Calcium Signaling; Cardiotonic Agents; | 2015 |
Protective effect of low dose gadolinium chloride against isoproterenol-induced myocardial injury in rat.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Apoptosis; Arachidonic Acid; Bronchodilator Age | 2015 |
Thirst and sodium appetite in rats with experimental nephrotic syndrome.
Topics: Angiotensin II; Animals; Antibiotics, Antineoplastic; Appetite; Blood Pressure; Bronchodilator Agent | 2015 |
Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway.
Topics: Animals; Biomarkers; Cardiomegaly; Creatine Kinase, MB Form; Cytoprotection; Disease Models, Animal; | 2015 |
Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System.
Topics: Animals; Antioxidants; Apigenin; Biomarkers; Catalase; Creatine Kinase, MB Form; Cytoprotection; Dis | 2016 |
Puerarin prevents cardiac hypertrophy induced by pressure overload through activation of autophagy.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Cardiomegaly; Carrier Proteins; Disease | 2015 |
Roles of heat shock factor 1 in isoproterenol‑induced myocardial fibrosis in mice.
Topics: Animals; Cardiomyopathies; Collagen; Disease Models, Animal; DNA-Binding Proteins; Fibrosis; Gene Ex | 2015 |
Urinary Bladder Dysfunction in Transgenic Sickle Cell Disease Mice.
Topics: Acetanilides; Adenosine Triphosphate; Anemia, Sickle Cell; Animals; Atropine; Calcium Chloride; Carb | 2015 |
Protective effect of a polysaccharide from Salvia miltiorrhiza on isoproterenol (ISO)-induced myocardial injury in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Cardiotonic Agents; Creati | 2015 |
[Impact of transfection with recombinant adenovirus vector-mediated Klotho gene on myocardial remodeling in a rat model of heart failure].
Topics: Adenoviridae; Animals; Disease Models, Animal; Echocardiography; Gene Expression; Genetic Vectors; G | 2015 |
Cardioprotective effects of timosaponin B II from Anemarrhenae asphodeloides Bge on isoproterenol-induced myocardial infarction in rats.
Topics: Anemarrhena; Animals; Biomarkers; Blotting, Western; Cardiotonic Agents; Disease Models, Animal; Iso | 2015 |
Selective Connexin43 Inhibition Prevents Isoproterenol-Induced Arrhythmias and Lethality in Muscular Dystrophy Mice.
Topics: Adolescent; Animals; Arrhythmias, Cardiac; Connexin 43; Disease Models, Animal; Female; Humans; Isop | 2015 |
Relaxin inhibits cardiac fibrosis and endothelial-mesenchymal transition via the Notch pathway.
Topics: Animals; Cardiomyopathies; Cell Movement; Cells, Cultured; Collagen; Dipeptides; Disease Models, Ani | 2015 |
[THE STATUS OF CERTAIN PHYSIOLOGICAL ADRENERGIC RESPONSES IN ALBINO RATS DURING DEVELOPMENT OF EXPERIMENTAL HYPERTHYROIDISM].
Topics: Adrenergic alpha-Agonists; Animals; Body Temperature; Disease Models, Animal; Heart Rate; Hyperthyro | 2015 |
Anti-inflammatory, Antithrombotic and Cardiac Remodeling Preventive Effects of Eugenol in Isoproterenol-Induced Myocardial Infarction in Wistar Rat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarker | 2016 |
Insulin-like growth factor 1 prevents diastolic and systolic dysfunction associated with cardiomyopathy and preserves adrenergic sensitivity.
Topics: Animals; Cardiomyopathies; Cardiotonic Agents; Chromatography, High Pressure Liquid; Disease Models, | 2016 |
HDAC6 Promotes Cardiac Fibrosis Progression through Suppressing RASSF1A Expression.
Topics: Actins; Anilides; Animals; Cell Proliferation; Cells, Cultured; Collagen Type I; Collagen Type I, al | 2016 |
Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT.
Topics: Animals; Calcium; Calcium-Binding Proteins; Calsequestrin; Disease Models, Animal; Echocardiography; | 2015 |
Anti-platelet effects of nimesulide in isoproterenol-induced myocardial ischaemia and infarction in rabbits.
Topics: Animals; Disease Models, Animal; Isoproterenol; Myocardial Infarction; Platelet Activating Factor; P | 2015 |
Protective Effects of Cardamom in Isoproterenol-Induced Myocardial Infarction in Rats.
Topics: Animals; Antioxidants; Biomarkers; Cardiotonic Agents; Catalase; Creatine Kinase, MB Form; Disease M | 2015 |
[Effect of edaravone on oxidative stress and myocardial fibrosis induced by isoproterenol in rats].
Topics: Animals; Antipyrine; Cardiomyopathies; Collagen; Disease Models, Animal; Drugs, Chinese Herbal; Edar | 2015 |
Bone marrow mesenchymal stromal cells with CD47 high expression via the signal transducer and activators of transcription signaling pathway preventing myocardial fibrosis.
Topics: Animals; Antibodies, Bispecific; Cardiomyopathies; CD47 Antigen; Cells, Cultured; Collagen; Disease | 2015 |
[The Action of Apelin-12 and Its Analog on Hemodynamics and Cardiac Contractile Function of Rats With Isoproterenol-Induced Myocardial Lesion].
Topics: Animals; Disease Models, Animal; Hemodynamics; Intercellular Signaling Peptides and Proteins; Isopro | 2015 |
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety; Arrhythmias, Cardiac; Behavior, Animal; Biph | 2015 |
Amelioration of inflammation by phenolic rich methanolic extract of Ocimum sanctum Linn. leaves in isoproterenol induced myocardial infarction.
Topics: Animals; Antioxidants; Disease Models, Animal; Inflammation; Isoproterenol; Leukotriene B4; Male; Me | 2015 |
Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups.
Topics: Adrenergic beta-Agonists; Alzheimer Disease; Animals; Behavior, Animal; Blotting, Western; Brain; Ca | 2015 |
Terminalia arjuna (Roxb.) Wight & Arn. augments cardioprotection via antioxidant and antiapoptotic cascade in isoproterenol induced cardiotoxicity in rats.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Cytoprotection; Disease Models, Animal; Heart Diseases | 2015 |
Inhibition of Galectin-3 Pathway Prevents Isoproterenol-Induced Left Ventricular Dysfunction and Fibrosis in Mice.
Topics: Animals; Disease Models, Animal; Echocardiography; Fibrosis; Galectin 3; Gene Expression Regulation; | 2016 |
Cardiac Dysfunction in the BACHD Mouse Model of Huntington's Disease.
Topics: Adrenergic beta-Agonists; Aging; Animals; Apoptosis; Cardiomegaly; Disease Models, Animal; Fibrosis; | 2016 |
Cellular and ionic mechanisms underlying the effects of cilostazol, milrinone, and isoproterenol to suppress arrhythmogenesis in an experimental model of early repolarization syndrome.
Topics: Action Potentials; Animals; Cardiac Electrophysiology; Cardiovascular Agents; Cilostazol; Death, Sud | 2016 |
Molecular and biochemical evidence on the protective effects of embelin and carnosic acid in isoproterenol-induced acute myocardial injury in rats.
Topics: Abietanes; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Benzoquinones; Cardiotonic Ag | 2016 |
Selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model.
Topics: Actin Cytoskeleton; Animals; Calcium-Binding Proteins; Cardiomyopathy, Hypertrophic; Carrier Protein | 2016 |
Salivary Alterations in Rats with Experimental Chronic Kidney Disease.
Topics: Amylases; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Isoproterenol; Male; Nep | 2016 |
Speckle Tracking Based Strain Analysis Is Sensitive for Early Detection of Pathological Cardiac Hypertrophy.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Early Diagnosis; Echocardiography; Heart; Isoproteren | 2016 |
Overexpression of microRNA-99a Attenuates Cardiac Hypertrophy.
Topics: Angiotensin II; Animals; Cardiomegaly; Cell Enlargement; Cells, Cultured; Disease Models, Animal; Ge | 2016 |
Effect of aliskiren and carvedilol on expression of Ca(2+)/calmodulin-dependent protein kinase II δ-subunit isoforms in cardiac hypertrophy rat model.
Topics: Amides; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Carbazoles; Cardiomegaly; Carve | 2016 |
Paricalcitol Attenuates Cardiac Fibrosis and Expression of Endothelial Cell Transition Markers in Isoproterenol-Induced Cardiomyopathic Rats.
Topics: Actins; Animals; Cardiomyopathies; Disease Models, Animal; Endothelial Cells; Epithelial-Mesenchymal | 2016 |
Suppression of calcium‑sensing receptor ameliorates cardiac hypertrophy through inhibition of autophagy.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Calcium; Calcium-Calmodulin-Dependent Protein Kin | 2016 |
Cardioprotective effect of resveratrol analogue isorhapontigenin versus omega-3 fatty acids in isoproterenol-induced myocardial infarction in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biomarkers; Cardiotonic Agents; Diet | 2016 |
Mechanisms underlying the cardioprotective effect of Salvianic acid A against isoproterenol-induced myocardial ischemia injury in rats: Possible involvement of L-type calcium channels and myocardial contractility.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; C | 2016 |
Cardiac Specific Overexpression of hHole Attenuates Isoproterenol-Induced Hypertrophic Remodeling through Inhibition of Extracellular Signal-Regulated Kinases (ERKs) Signalling.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Fibrosis; Humans; Intracellular Signaling Peptides an | 2016 |
Role of SERCA and the sarcoplasmic reticulum calcium content on calcium waves propagation in rat ventricular myocytes.
Topics: Animals; Calcium; Calcium Signaling; Calcium-Binding Proteins; Cytosol; Disease Models, Animal; Hear | 2016 |
miR-218 Involvement in Cardiomyocyte Hypertrophy Is Likely through Targeting REST.
Topics: Animals; Cells, Cultured; Constriction, Pathologic; Disease Models, Animal; Down-Regulation; Gene Ex | 2016 |
Effect of Cardiovascular Injury on Catabolism of Adenosine and Adenosine 5-'Triphosphate in Systemic Blood in a Freely Moving Rat Model In Vivo.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cardiova | 2016 |
Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model.
Topics: Animals; Disease Models, Animal; Echocardiography; Galectin 3; Gene Expression Regulation; Heart Fai | 2016 |
The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high-energy phosphate metabolism.
Topics: Adenosine Triphosphate; Animals; Apoptosis Regulatory Proteins; Aryl Hydrocarbon Receptor Nuclear Tr | 2016 |
Type III Transforming Growth Factor-β Receptor Drives Cardiac Hypertrophy Through β-Arrestin2-Dependent Activation of Calmodulin-Dependent Protein Kinase II.
Topics: Analysis of Variance; Animals; beta-Arrestin 2; Biopsy, Needle; Calcium-Calmodulin-Dependent Protein | 2016 |
Spironolactone Prevents Endothelial Nitric Oxide Synthase Uncoupling and Vascular Dysfunction Induced by β-Adrenergic Overstimulation: Role of Perivascular Adipose Tissue.
Topics: Adipose Tissue; Analysis of Variance; Animals; Cardiomegaly; Disease Models, Animal; Isoproterenol; | 2016 |
Anti-inflammatory and anti-thrombotic effects of zingerone in a rat model of myocardial infarction.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Disease Models, Animal; Fibrinolytic Agents; Glyceral | 2016 |
A Periodontal pathogen Porphyromonas gingivalis deteriorates Isoproterenol-Induced myocardial remodeling in mice.
Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Disease Models, Animal; Heart; Isoproterenol; Mice, | 2017 |
Chlorogenic acid a dietary polyphenol attenuates isoproterenol induced myocardial oxidative stress in rat myocardium: An in vivo study.
Topics: Animals; Antioxidants; Biomarkers; Chlorogenic Acid; Disease Models, Animal; Dose-Response Relations | 2016 |
Sex-Specific Effects of Adrenergic-Induced Left Ventricular Remodeling in Spontaneously Hypertensive Rats.
Topics: Adrenergic Agents; Animals; Cells, Cultured; Disease Models, Animal; Female; Isoproterenol; Male; My | 2017 |
Chronic stress accelerates the development of endometriosis in mouse through adrenergic receptor β2.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals | 2016 |
Gallic acid prevents isoproterenol-induced cardiac hypertrophy and fibrosis through regulation of JNK2 signaling and Smad3 binding activity.
Topics: Animals; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Fibrosis; Gallic Acid; Gene Expressi | 2016 |
Impact of cardiac-specific expression of CD39 on myocardial infarct size in mice.
Topics: Animals; Antigens, CD; Apyrase; Calcium; Disease Models, Animal; Echocardiography; Gene Expression; | 2017 |
Reduction of atrial fibrillation by Tanshinone IIA in chronic heart failure.
Topics: Abietanes; Acetylcholine; Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; A | 2016 |
Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve.
Topics: A Kinase Anchor Proteins; Animals; Calcineurin; Calcium Signaling; Calcium-Binding Proteins; Cardiom | 2017 |
Compound danshen dripping pills modulate the perturbed energy metabolism in a rat model of acute myocardial ischemia.
Topics: Animals; Camphanes; Disease Models, Animal; Drugs, Chinese Herbal; Energy Metabolism; Fatty Acids; G | 2016 |
Nutraceutical inherent of Spinacia oleracea Linn. methanolic leaf extract ameliorates isoproterenol induced myocardial necrosis in male albino Wistar rats via mitigating inflammation.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cardiomyopathies; Chromatography, High Pressure Liquid | 2017 |
Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma.
Topics: Animals; Asthma; Cell Adhesion; Cell Line; Chymases; Disease Models, Animal; Humans; Integrin alpha5 | 2017 |
Protective effects of low-dose rosuvastatin on isoproterenol-induced chronic heart failure in rats by regulation of DDAH-ADMA-NO pathway.
Topics: Amidohydrolases; Animals; Biomarkers; Cardiotonic Agents; Disease Models, Animal; Fibrosis; Heart Fa | 2017 |
Superimposed pressure oscillations: An alternative to treat airway hyperresponsiveness in an acute sensitized airways mouse model.
Topics: Acetylcholine; Acute Disease; Animals; Bronchodilator Agents; Disease Models, Animal; Female; Isopro | 2017 |
Anaesthetic-induced cardioprotection in an experimental model of the Takotsubo syndrome - isoflurane vs. propofol.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Disease Models, Animal; Echocardiography | 2017 |
CaMKII inhibition reduces isoproterenol-induced ischemia and arrhythmias in hypertrophic mice.
Topics: Animals; Arrhythmias, Cardiac; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; Car | 2017 |
Comparison of pharmacodynamics between carvedilol and metoprolol in rats with isoproterenol-induced cardiac hypertrophy: effects of carvedilol enantiomers.
Topics: Adenylyl Cyclases; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressur | 2008 |
Serotonin 5-HT(2B) receptor blockade prevents reactive oxygen species-induced cardiac hypertrophy in mice.
Topics: Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Echocardiography, Doppler; Indoles; I | 2008 |
Granulocyte-colony stimulating factor increases donor mesenchymal stem cells in bone marrow and their mobilization into peripheral circulation but does not repair dystrophic heart after bone marrow transplantation.
Topics: Adrenergic beta-Agonists; Animals; Bone Marrow Transplantation; Cardiomyopathies; Cell Differentiati | 2008 |
Combined transplantation of endothelial progenitor cells and mesenchymal stem cells into a rat model of isoproterenol-induced myocardial injury.
Topics: Angiopoietin-2; Animals; Cardiotonic Agents; Disease Models, Animal; Endothelium, Vascular; Female; | 2008 |
Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy.
Topics: Adrenergic beta-Agonists; Animals; Arrhythmias, Cardiac; Calcium; Calcium-Binding Proteins; Catechol | 2008 |
Protective effect of aspartate and glutamate on cardiac mitochondrial function during myocardial infarction in experimental rats.
Topics: Animals; Aspartic Acid; Disease Models, Animal; Enzyme Activation; Glutamic Acid; Glutathione; Gluta | 2008 |
Naringin ameliorates mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol-induced myocardial infarction in Wistar rats.
Topics: Animals; Antioxidants; Cardiotonic Agents; Disease Models, Animal; Flavanones; Isoproterenol; Lipid | 2009 |
Dissociation between cardiomyocyte function and remodeling with beta-adrenergic receptor blockade in isolated canine mitral regurgitation.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Anima | 2008 |
Prophylactic role of oral L-arginine on histological and contractile changes in a rat chronic bladder injury model.
Topics: Administration, Oral; Adrenergic beta-Agonists; Animals; Arginine; Carbachol; Cholinergic Agonists; | 2008 |
Limited functional and metabolic improvements in hypertrophic and healthy rat heart overexpressing the skeletal muscle isoform of SERCA1 by adenoviral gene transfer in vivo.
Topics: Adenosine Triphosphate; Adenoviridae; Adrenergic beta-Agonists; Animals; Calcium-Binding Proteins; C | 2008 |
Activation of endothelial nitric oxide synthase by a vanadium compound ameliorates pressure overload-induced cardiac injury in ovariectomized rats.
Topics: Animals; Blood Pressure; Calcium-Binding Proteins; Cardiotonic Agents; Disease Models, Animal; Dose- | 2009 |
N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin.
Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Body Weight; Cardiac Output; Cardiomegaly; Cardio | 2009 |
[Fenofibrate improves energy metabolism and attenuates isoproterenol induced acute myocardial ischemic injury in rats via PPAR alpha activation].
Topics: Animals; Disease Models, Animal; Energy Metabolism; Fenofibrate; Isoproterenol; Male; Myocardial Isc | 2008 |
Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biomarkers; Cardiotonic Ag | 2009 |
Influence of autonomic stimulation on the genesis of atrial fibrillation in remodeled canine atria not the same as in normal atria.
Topics: Action Potentials; Animals; Atrial Fibrillation; Atrioventricular Node; Cardiotonic Agents; Catheter | 2009 |
Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation.
Topics: Animals; Blood Pressure; Calcium; Carbachol; Cardiac Myosins; Cardiotonic Agents; Disease Models, An | 2009 |
Inhibition of integrin alphavbeta3 prevents urokinase plasminogen activator-mediated impairment of cerebrovasodilation after cerebral hypoxia/ischemia.
Topics: Adrenergic beta-Agonists; Animals; Animals, Newborn; Antibodies; Cerebrovascular Circulation; Diseas | 2009 |
Mechanism of protective action of mangiferin on suppression of inflammatory response and lysosomal instability in rat model of myocardial infarction.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Hydrolases; Isoproterenol; Lysosomes; Male; Myo | 2009 |
Chronic partial unloading restores beta-adrenergic responsiveness and reverses receptor downregulation in failing rat hearts.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Gene Expression; Heart Failure; Heart Transplan | 2009 |
Efficacy of grape seed proanthocyanidins on cardioprotection during isoproterenol-induced myocardial injury in rats.
Topics: Administration, Oral; Animals; Antioxidants; Biomarkers; Blood Chemical Analysis; Cardiotonic Agents | 2009 |
Targeted expression of receptor-associated late transducer inhibits maladaptive hypertrophy via blocking epidermal growth factor receptor signaling.
Topics: Adenoviridae; Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Collagen; Disease Models, Anim | 2009 |
Stimulation of kappa-opioid receptor reduces isoprenaline-induced cardiac hypertrophy and fibrosis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; A | 2009 |
Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth.
Topics: Adaptation, Physiological; Animals; Apoptosis; Blood Pressure; Cardiomegaly; Disease Models, Animal; | 2009 |
Partial downregulation of junctin enhances cardiac calcium cycling without eliciting ventricular arrhythmias in mice.
Topics: Aging; Animals; Arrhythmias, Cardiac; Caffeine; Calcium Signaling; Calcium-Binding Proteins; Disease | 2009 |
Cardioprotective potential of myricetin in isoproterenol-induced myocardial infarction in Wistar rats.
Topics: Animals; Aspartate Aminotransferases; Biomarkers; Catalase; Creatine Kinase; Disease Models, Animal; | 2009 |
Increased leukotriene concentration in submandibular glands from rats with experimental periodontitis.
Topics: Adrenergic beta-Agonists; Animals; Disease Models, Animal; Isoproterenol; Leukotrienes; Male; Mucins | 2009 |
Oestrogen confers cardioprotection by suppressing Ca2+/calmodulin-dependent protein kinase II.
Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Benzylamines; Calcium Signaling; Calcium-Calmodulin-De | 2009 |
Pulmonary hypertension modifies responsiveness of sinoatrial cells of rat hearts to adrenomimetics and activators of ATP-sensitive K+ channels in a gender-dependent way.
Topics: Adrenergic beta-Agonists; Animals; Anti-Arrhythmia Agents; Chromans; Disease Models, Animal; Female; | 2009 |
Gallic acid prevents lysosomal damage in isoproterenol induced cardiotoxicity in Wistar rats.
Topics: Acetylglucosaminidase; Adrenergic beta-Agonists; Animals; Antioxidants; beta-Galactosidase; Biomarke | 2009 |
Cardioprotective actions of ascorbic acid during isoproterenol-induced acute myocardial infarction in rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Do | 2009 |
IL-17 induces myocardial fibrosis and enhances RANKL/OPG and MMP/TIMP signaling in isoproterenol-induced heart failure.
Topics: Animals; Disease Models, Animal; Fibrosis; Heart Failure; Interleukin-17; Isoproterenol; Male; Matri | 2009 |
Regulation of renovascular adenosine 3',5'-cyclic monophosphate in spontaneously hypertensive rats.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Analysis of Variance; Animals; Blood Pressure; Blood | 2009 |
Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain.
Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Cardiomyopathies; Disease Models, Animal; Isoproter | 2009 |
Delayed restoration of Mg2+ content and transport in liver cells following ethanol withdrawal.
Topics: Adrenergic Agonists; Alcohol Drinking; Alcoholism; Animals; Biological Transport; Bucladesine; Cell | 2009 |
Mechanisms of stretch-induced atrial fibrillation in the presence and the absence of adrenocholinergic stimulation: interplay between rotors and focal discharges.
Topics: Acetylcholine; Adrenergic beta-Agonists; Animals; Atrial Fibrillation; Cholinergic Agents; Disease M | 2009 |
[Protective effect of Buyanghuanwu Decoction on myocardial ischemia induced by isoproterenol in rats].
Topics: Animals; Aspartate Aminotransferases; Cardiotonic Agents; CD40 Antigens; CD40 Ligand; Creatine Kinas | 2009 |
miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy.
Topics: Aldosterone; Animals; Base Sequence; Calcineurin; Cardiomegaly; Cell Line; Disease Models, Animal; G | 2009 |
MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotection.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Cyclic AMP-Dep | 2009 |
Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction.
Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-Agonists; Animals; Apoptosis; Calcium-Calmoduli | 2009 |
Myocardial salvaging effect of telmisartan in experimental model of myocardial infarction.
Topics: Animals; Benzimidazoles; Benzoates; Biomarkers; Body Weight; Cardiotonic Agents; Catalase; Disease M | 2009 |
Exercise training provides cardioprotection via a reduction in reactive oxygen species in rats submitted to myocardial infarction induced by isoproterenol.
Topics: Animals; Biomarkers; Catalase; Creatine Kinase, MB Form; Disease Models, Animal; Isoproterenol; Male | 2009 |
The phenotype and potential origin of nestin+ cardiac myocyte-like cells following infarction.
Topics: Adrenergic beta-Agonists; Animals; Cell Differentiation; Cell Movement; Connexin 43; Disease Models, | 2009 |
Preventive effect of amiodarone during acute period in isoproterenol-induced myocardial injury in Wistar rats.
Topics: Amiodarone; Animals; Cardiotonic Agents; Disease Models, Animal; Isoproterenol; Male; Myocardial Inf | 2009 |
Left ventricular function of isoproterenol-induced hypertrophied rat hearts perfused with blood: mechanical work and energetics.
Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Blotting, Western; Calcium-Binding Proteins; Card | 2009 |
Gene expression profiling: classification of mice with left ventricle systolic dysfunction using microarray analysis.
Topics: Animals; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Isoprotereno | 2010 |
Cardiac biomarkers in a model of acute catecholamine cardiotoxicity.
Topics: Animals; Antioxidants; Ascorbic Acid; Biomarkers; Blood Pressure; Calcium; Catecholamines; Disease M | 2009 |
Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity.
Topics: Adrenergic beta-Agonists; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Exercise; Gene | 2009 |
Isoproterenol induces in vivo functional and metabolic abnormalities: similar to those found in the infarcted rat heart.
Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Disease Models, Animal; Fatty Acid Transport Prot | 2009 |
Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness.
Topics: Animals; Cardiomegaly; Cell Size; Disease Models, Animal; Gene Expression Regulation; Humans; Inosit | 2009 |
Mechanisms of sinoatrial node dysfunction in a canine model of pacing-induced atrial fibrillation.
Topics: Adrenergic beta-Agonists; Animals; Atrial Fibrillation; Caffeine; Calcium; Calcium Channels, L-Type; | 2010 |
Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure.
Topics: Animals; Arrhythmias, Cardiac; Benzylamines; Calcium; Calcium Channels, L-Type; Calcium Signaling; C | 2009 |
Adrenergic stimulation promotes T-wave alternans and arrhythmia inducibility in a TNF-alpha genetic mouse model of congestive heart failure.
Topics: Adrenergic beta-Agonists; Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Disease Models, A | 2010 |
Pretreatment with a combination of quercetin and alpha-tocopherol ameliorates adenosine triphosphatases and lysosomal enzymes in myocardial infarcted rats.
Topics: Adenosine Triphosphatases; alpha-Tocopherol; Animals; Antioxidants; Ca(2+) Mg(2+)-ATPase; Cell Membr | 2010 |
[Effects of extracts of Ginkgo biloba leaves on apelin concentration and expressions in plasma and myocardium of rats with myocardial ischemia injury].
Topics: Animals; Apelin; Cardiotonic Agents; Carrier Proteins; Disease Models, Animal; Female; Ginkgo biloba | 2009 |
Aspartate and glutamate prevents isoproterenol-induced cardiac toxicity by alleviating oxidative stress in rats.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Aspartic Acid; Cardiotonic Agents; Disease Models, An | 2011 |
Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure.
Topics: Analysis of Variance; Animals; Cardiomegaly; Cell Size; Cluster Analysis; Disease Models, Animal; Ge | 2009 |
Dose-dependent actions of curcumin in experimentally induced myocardial necrosis: a biochemical, histopathological, and electron microscopic evidence.
Topics: Administration, Oral; Animals; Creatine Kinase; Curcumin; Disease Models, Animal; Dose-Response Rela | 2010 |
Analysis of isovolumic relaxation in failing hearts by monoexponential time constants overestimates lusitropic change and load dependence: mechanisms and advantages of alternative logistic fit.
Topics: Animals; Chi-Square Distribution; Diastole; Disease Models, Animal; Dogs; Heart Failure; Hemodynamic | 2010 |
Cellular basis for atrial fibrillation in an experimental model of short QT1: implications for a pharmacological approach to therapy.
Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atri | 2010 |
Attenuation of isoproterenol-induced cardiac fibrosis in transgenic rats harboring an angiotensin-(1-7)-producing fusion protein in the heart.
Topics: Angiotensin I; Animals; Arrhythmias, Cardiac; Blood Pressure; Calcium; Disease Models, Animal; Fibro | 2010 |
Particulate matter inhalation exacerbates cardiopulmonary injury in a rat model of isoproterenol-induced cardiomyopathy.
Topics: Adrenergic beta-Agonists; Air Pollutants; Animals; Cardiomyopathies; Disease Models, Animal; Drug Sy | 2010 |
KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways.
Topics: Animals; Calcineurin; Cardiomegaly; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models | 2010 |
Myoglobin-deficient mice activate a distinct cardiac gene expression program in response to isoproterenol-induced hypertrophy.
Topics: Adaptation, Physiological; Animals; Cluster Analysis; Disease Models, Animal; Gene Expression Profil | 2010 |
Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.
Topics: Animals; Caffeine; Calcium Signaling; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Disease | 2010 |
Constitutive glycogen synthase kinase-3alpha/beta activity protects against chronic beta-adrenergic remodelling of the heart.
Topics: Adrenergic beta-Agonists; Age Factors; Animals; Apoptosis; Cardiomegaly; Disease Models, Animal; Enz | 2010 |
Isoproterenol-induced myocardial injury: a systematic comparison of subcutaneous versus intraperitoneal delivery in a rat model.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Female; Heart Injuries; Humans; Injections, Int | 2010 |
Prolonged mechanical unloading preserves myocardial contractility but impairs relaxation in rat heart of dilated cardiomyopathy accompanied by myocardial stiffness and apoptosis.
Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Cardiomyopathy, Dilated; Collagen Type I; Diastole; Di | 2010 |
PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia.
Topics: Animals; Animals, Newborn; Anthracenes; Blood Pressure; Carbon Dioxide; Cardiovascular Agents; Cereb | 2010 |
[Evaluation on a fast weight reduction model in vitro].
Topics: Adipocytes; Animals; Anti-Obesity Agents; Caffeine; Cells, Cultured; Curcumin; Disease Models, Anima | 2010 |
Cardioprotective effects of aqueous extract of Oxalis corniculata in experimental myocardial infarction.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Free Radical Scavengers; Isoproterenol; Magnoli | 2011 |
The IP3 receptor regulates cardiac hypertrophy in response to select stimuli.
Topics: Age Factors; Angiotensin II; Animals; Arrhythmias, Cardiac; Calcineurin; Calcium Signaling; Cardiome | 2010 |
Peripheral benzodiazepine receptor ligand Ro5-4864 inhibits isoprenaline-induced cardiac hypertrophy in rats.
Topics: Animals; Antioxidants; Benzodiazepinones; Cardiomegaly; Disease Models, Animal; Dose-Response Relati | 2010 |
Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: A biochemical, electrocardiographic and histoarchitectural evaluation.
Topics: Animals; Antioxidants; Cardiotonic Agents; Disease Models, Animal; Electrocardiography; Inflammation | 2010 |
CPU228, a derivative of dofetilide, relieves cardiac dysfunction by normalizing FKBP12.6, NADPH oxidase and protein kinase C epsilon in the myocardium.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regu | 2010 |
Anti-hypoxia activity and related components of Rhodobryum giganteum par.
Topics: Animals; Bryophyta; Cinnamates; Coumarins; Disease Models, Animal; Hypoxia; Isoproterenol; Male; Mic | 2011 |
Altered ion transport by thyroid epithelia from CFTR(-/-) pigs suggests mechanisms for hypothyroidism in cystic fibrosis.
Topics: Amiloride; Animals; Cells, Cultured; Chloride Channels; Chlorides; Cystic Fibrosis; Cystic Fibrosis | 2010 |
Myocardial function with reduced expression of the sodium-calcium exchanger.
Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Aorta; Cardiac Output; Disease Models, Anim | 2010 |
Drug-disease interaction: reduced verapamil response in isoproterenol-induced myocardial injury in rats.
Topics: Animals; Blotting, Western; Calcium Channel Blockers; Calcium Channels, L-Type; Disease Models, Anim | 2010 |
Ramipril-like activity of Spondias mombin linn against no-flow ischemia and isoproterenol-induced cardiotoxicity in rat heart.
Topics: Anacardiaceae; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiovascular Agents; Catalase; C | 2010 |
Lipotab, a polyherbal formulation, attenuates isoprenaline-induced left ventricular remodeling and heart failure in rats.
Topics: Administration, Oral; Animals; Antioxidants; Body Weight; Disease Models, Animal; Female; Glutathion | 2011 |
Ca2+ clock malfunction in a canine model of pacing-induced heart failure.
Topics: Adrenergic beta-Agonists; Animals; Caffeine; Calcium Signaling; Cardiac Pacing, Artificial; Circadia | 2010 |
Cardioprotective effect of lemon grass as evidenced by biochemical and histopathological changes in experimentally induced cardiotoxicity.
Topics: Animals; Antioxidants; Cymbopogon; Disease Models, Animal; Dose-Response Relationship, Drug; Heart D | 2011 |
The study of ISO induced heart failure rat model, Exp Mol Pathol. 2010;88:299-304.
Topics: Animal Experimentation; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Fai | 2011 |
In the RyR2(R4496C) mouse model of CPVT, β-adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves.
Topics: Adrenergic Agents; Animals; Calcium; Calcium Signaling; Disease Models, Animal; Isoproterenol; Mice; | 2010 |
Pyruvate attenuates cardiac dysfunction and oxidative stress in isoproterenol-induced cardiotoxicity.
Topics: Adrenergic beta-Agonists; Animals; Cardiotonic Agents; Disease Models, Animal; Heart; Hemodynamics; | 2012 |
Oligomerized grape seed proanthocyanidins ameliorates isoproterenol-induced cardiac remodeling in rats: role of oxidative stress.
Topics: Animals; Antioxidants; Cardiotonic Agents; Cyclooxygenase 2; Disease Models, Animal; Grape Seed Extr | 2011 |
Efficacy of hesperidin on plasma, heart and liver tissue lipids in rats subjected to isoproterenol-induced cardiotoxicity.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Heart; Hesperidin; Isoproterenol; Lipid Metabol | 2012 |
Mechanistic clues in the cardioprotective effect of Terminalia arjuna bark extract in isoproterenol-induced chronic heart failure in rats.
Topics: Animals; Cardiac Output; Cardiotonic Agents; Chronic Disease; Creatine Kinase, MB Form; Disease Mode | 2011 |
Acid-sensing ion channel 3, but not capsaicin receptor TRPV1, plays a protective role in isoproterenol-induced myocardial ischemia in mice.
Topics: Acid Sensing Ion Channels; Animals; Disease Models, Animal; Electrocardiography, Ambulatory; Fibrosi | 2011 |
[Effect of Chrysanthemum indicum on ventricular remodeling in rats].
Topics: Aldosterone; Angiotensin II; Animals; Chrysanthemum; Disease Models, Animal; Drugs, Chinese Herbal; | 2010 |
Crocus sativus L. (saffron) attenuates isoproterenol-induced myocardial injury via preserving cardiac functions and strengthening antioxidant defense system.
Topics: Animals; Antioxidants; Cardiotonic Agents; Crocus; Disease Models, Animal; Heart; Heart Diseases; He | 2012 |
Preventive effects of vanillic acid on lipids, bax, bcl-2 and myocardial infarct size on isoproterenol-induced myocardial infarcted rats: a biochemical and in vitro study.
Topics: Animals; bcl-2-Associated X Protein; Biphenyl Compounds; Creatine Kinase, MB Form; Disease Models, A | 2011 |
Time-dependent responses of rat troponin I and cardiac injury following isoproterenol administration.
Topics: Animals; Biomarkers; Cardiotonic Agents; Disease Models, Animal; Heart; Isoproterenol; Male; Myocard | 2011 |
Chronic and acute exposure of mouse hearts to fatty acids increases oxygen cost of excitation-contraction coupling.
Topics: Animals; Basal Metabolism; Cardiotonic Agents; Diabetes Mellitus, Type 2; Disease Models, Animal; Do | 2011 |
Ureteral selectivity of intravenous β-adrenoceptor agonists in pig model of acute ureteral obstruction: comparison of KUL-7211, a selective β2/β3 agonist, with isoproterenol, terbutaline, and CL-316243.
Topics: Acetates; Acute Disease; Adrenergic beta-Agonists; Animals; Dioxoles; Disease Models, Animal; Inject | 2011 |
Icariin attenuates cardiac remodelling through down-regulating myocardial apoptosis and matrix metalloproteinase activity in rats with congestive heart failure.
Topics: Angiotensin II; Animals; Apoptosis; Cardiotonic Agents; Disease Models, Animal; Down-Regulation; Fla | 2011 |
Myocardial structural, contractile and electrophysiological changes in the guinea-pig heart failure model induced by chronic sympathetic activation.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Cardiomyopathies; Disease Models, Animal; Guin | 2011 |
Membrane sealant Poloxamer P188 protects against isoproterenol induced cardiomyopathy in dystrophin deficient mice.
Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Aortic Valve; Blood Pressure; Body Weight; | 2011 |
An in vivo and in vitro study on the protective effects of N-acetylcysteine on mitochondrial dysfunction in isoproterenol treated myocardial infarcted rats.
Topics: Acetylcysteine; Animals; Antioxidants; Creatine Kinase; Data Interpretation, Statistical; Disease Mo | 2013 |
Sex differences in the electrophysiological characteristics of pulmonary veins and left atrium and their clinical implication in atrial fibrillation.
Topics: Acetylcholine; Action Potentials; Adenosine; Animals; Atrial Fibrillation; Autonomic Nervous System; | 2011 |
Short communication: flecainide exerts an antiarrhythmic effect in a mouse model of catecholaminergic polymorphic ventricular tachycardia by increasing the threshold for triggered activity.
Topics: Animals; Anti-Arrhythmia Agents; Calcium Signaling; Disease Models, Animal; Extracellular Space; Fle | 2011 |
Isoproterenol-induced cardiomyopathy in rats: influence of Acorus calamus Linn.: A. calamus attenuates cardiomyopathy.
Topics: Acorus; Amlodipine; Animals; Antioxidants; Calcineurin; Cardiomyopathies; Catalase; Disease Models, | 2011 |
Pretreatment with morin, a flavonoid, ameliorates adenosine triphosphatases and glycoproteins in isoproterenol-induced myocardial infarction in rats.
Topics: Adenosine Triphosphatases; Animals; Biomarkers; Disease Models, Animal; Flavonoids; Glycoproteins; I | 2012 |
Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice.
Topics: Animals; Cardiac Imaging Techniques; Cardiomyopathies; Cardiotonic Agents; Disease Models, Animal; D | 2011 |
Terminalia arjuna enhances baroreflex sensitivity and myocardial function in isoproterenol-induced chronic heart failure rats.
Topics: Animals; Antioxidants; Baroreflex; Chronic Disease; Cytokines; Disease Models, Animal; Fatty Acids, | 2012 |
NHE-1 participates in isoproterenol-induced downregulation of SERCA2a and development of cardiac remodeling in rat hearts.
Topics: Animals; Calcium Signaling; Calcium-Binding Proteins; Cardiomegaly; Collagen; Disease Models, Animal | 2011 |
Impact of L-NAME on the cardiopulmonary reflex in cardiac hypertrophy.
Topics: Animals; Baroreflex; Blood Pressure; Blood Volume; Caffeine; Cardiomegaly; Disease Models, Animal; D | 2011 |
G-protein-associated signal transduction processes are restored after postweaning environmental enrichment in Ts65Dn, a Down syndrome mouse model.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic alpha-Agonists; Adrenergic be | 2011 |
GATA6 reporter gene reveals myocardial phenotypic heterogeneity that is related to variations in gap junction coupling.
Topics: Adherens Junctions; Animals; beta-Galactosidase; Cardiomegaly; Cell Communication; Cells, Cultured; | 2011 |
Cold exposure down-regulates adiponutrin/PNPLA3 mRNA expression and affects its nutritional regulation in adipose tissues of lean and obese Zucker rats.
Topics: Adipocytes; Adipose Tissue; Animal Nutrition Sciences; Animals; Blood Glucose; Body Weight; Cells, C | 2012 |
Seabuckthorn attenuates cardiac dysfunction and oxidative stress in isoproterenol-induced cardiotoxicity in rats.
Topics: Animals; Antioxidants; Blood Pressure; Catalase; Creatine Kinase, MB Form; Disease Models, Animal; G | 2011 |
Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A.
Topics: Animals; Calcium; Cardiomegaly; Disease Models, Animal; Echocardiography; Enzyme Activation; Extrace | 2011 |
Functional consequences of stably expressing a mutant calsequestrin (CASQ2D307H) in the CASQ2 null background.
Topics: Animals; Calcium; Calcium Signaling; Calsequestrin; Cardiac Pacing, Artificial; Cardiotonic Agents; | 2012 |
Attenuated ventricular β-adrenergic response and reduced repolarization reserve in a rabbit model of chronic heart failure.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Cardiac Pacing, Artificial; Chronic Disease; D | 2012 |
Protective effects of Carthamus tinctorius injection on isoprenaline-induced myocardial injury in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cardiovascular Agents; Carthamus tinctorius; Disease | 2011 |
Puerarin prevents isoprenaline-induced myocardial fibrosis in mice by reduction of myocardial TGF-β1 expression.
Topics: Animals; Biological Products; Cardiomyopathies; Cardiotonic Agents; Collagen; Disease Models, Animal | 2012 |
Cytoskeletal role in protection of the failing heart by β-adrenergic blockade.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Agon | 2012 |
Identification of proteins responding to adrenergic receptor subtype-specific hypertrophy in cardiomyocytes by proteomic approaches.
Topics: Acetylcysteine; Animals; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Electrophoresis, Gel | 2011 |
Catecholamine-induced cardiac mitochondrial dysfunction and mPTP opening: protective effect of curcumin.
Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Cardiomegaly; Cardiotonic Agents; Catecholamines; Curc | 2012 |
Heart-type fatty acid-binding protein and its relation with morphological changes in rat myocardial damage model induced by isoproterenol.
Topics: Animals; Biomarkers; Cardiomyopathies; Disease Models, Animal; Fatty Acid Binding Protein 3; Fatty A | 2011 |
Cardioprotective effect of water and ethanol extract of Salvia miltiorrhiza in an experimental model of myocardial infarction.
Topics: Administration, Oral; Animals; Biomarkers; Camphanes; Cardiotonic Agents; Disease Models, Animal; Dr | 2012 |
Focal initiation of sustained and nonsustained ventricular tachycardia in a canine model of ischemic cardiomyopathy.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Cardiac Pacing, Artificial; Cardiomyopathies; | 2012 |
Altered β-adrenergic response in mice lacking myotonic dystrophy protein kinase.
Topics: Adrenergic beta-Agonists; Animals; Cell Membrane; Disease Models, Animal; Dose-Response Relationship | 2012 |
Shortened Ca2+ signaling refractoriness underlies cellular arrhythmogenesis in a postinfarction model of sudden cardiac death.
Topics: Adrenergic beta-Agonists; Animals; Benzylamines; Caffeine; Calcium Channel Agonists; Calcium Signali | 2012 |
The autoimmune nature of post-infarct myocardial healing: oral tolerance to cardiac antigens as a novel strategy to improve cardiac healing.
Topics: Animals; Autoantigens; Autoimmunity; Cytokines; Disease Models, Animal; Female; Forkhead Transcripti | 2012 |
Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.
Topics: Adrenergic beta-Agonists; Animals; Autonomic Nervous System; Biopterins; Bradycardia; Disease Models | 2012 |
[Protective effects of Leonurus japonicas on myocardial remodeling induced by isoproterenol in rats].
Topics: Animals; Antioxidants; Collagen; Disease Models, Animal; Hemodynamics; Hydroxyproline; Immunohistoch | 2011 |
In vivo β-adrenergic blockade by propranolol prevents isoproterenol-induced polycystic ovary in adult rats.
Topics: Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Female; Humans; Isoproterenol; Luteini | 2012 |
Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired β-adrenoceptor-mediated relaxation of renal arteries in hypertension.
Topics: Adrenergic beta-Agonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Kn | 2012 |
Cardioprotective effect of HPLC standardized ethanolic extract of Terminalia pallida fruits against isoproterenol-induced myocardial infarction in albino rats.
Topics: Adenosine Triphosphatases; Animals; Antioxidants; Biomarkers; Cardiovascular Agents; Chromatography, | 2012 |
[Effect of compatibilities and proportions of shuanglong formula on acute myocardial infarction in rats].
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Electrocardiography; Isoproterenol; Male; My | 2011 |
Acute initial haemodynamic changes in a rat isoprenaline model of cardiotoxicity.
Topics: Adrenergic beta-Agonists; Animals; Cardiotoxins; Disease Models, Animal; Heart; Hemodynamics; Isopro | 2012 |
Combined effects of quercetin and atenolol in reducing isoproterenol-induced cardiotoxicity in rats: possible mediation through scavenging free radicals.
Topics: Administration, Oral; Adrenergic beta-Agonists; Animals; Antihypertensive Agents; Atenolol; Cardioto | 2012 |
Beta-adrenoreceptor agonism influences retinal responses to hypoxia in a model of retinopathy of prematurity.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Arrestins; beta-Arrestins; Blood Pressure; Blo | 2012 |
Testosterone improves cardiac function and alters angiotensin II receptors in isoproterenol-induced heart failure.
Topics: Animals; Apoptosis; Blotting, Western; Disease Models, Animal; Fibrosis; Heart Failure; Hemodynamics | 2012 |
Dexrazoxane provided moderate protection in a catecholamine model of severe cardiotoxicity.
Topics: Animals; Calcium; Cardiotonic Agents; Disease Models, Animal; Hemodynamics; Iron; Iron Chelating Age | 2012 |
Genetic suppression of Gαs protein provides rate control in atrial fibrillation.
Topics: Adrenergic beta-Agonists; Animals; Atrial Fibrillation; Atrioventricular Node; Cardiac Pacing, Artif | 2012 |
Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats.
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Cardiotonic Agents; Creatine Kinase; Disease Mod | 2012 |
Velocity vector imaging fails to quantify regional myocardial dysfunction in a mouse model of isoprenaline-induced cardiotoxicity.
Topics: Algorithms; Animals; Disease Models, Animal; Echocardiography; Elasticity Imaging Techniques; Humans | 2012 |
[Antibodies against the second extracellular loop of beta1-adrenergic receptor induce aortic endothelial dysfunction in Wistar rat].
Topics: Acetylcholine; Adrenergic beta-Agonists; Algorithms; Animals; Aorta; Autoantibodies; Computer Graphi | 2012 |
Beneficial role of spironolactone, telmisartan and their combination on isoproterenol-induced cardiac hypertrophy.
Topics: Adrenergic beta-Agonists; Algorithms; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazol | 2012 |
Effect of ginsenoside Rh1 on myocardial injury and heart function in isoproterenol-induced cardiotoxicity in rats.
Topics: Animals; Blood Pressure; Cardiotonic Agents; Creatine Kinase; Disease Models, Animal; Ginsenosides; | 2012 |
Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Disease Susceptibility; Fibrosis; Interleukin-10; Iso | 2012 |
Paradoxical effect of increased diastolic Ca(2+) release and decreased sinoatrial node activity in a mouse model of catecholaminergic polymorphic ventricular tachycardia.
Topics: Action Potentials; Adrenergic beta-Agonists; Adult; Aged; Animals; Calcium; Calcium Signaling; Disea | 2012 |
An analysis of the myocardial transcriptome in a mouse model of cardiac dysfunction with decreased cholinergic neurotransmission.
Topics: Animals; Cholinergic Agents; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regu | 2012 |
Sulfur dioxide restores calcium homeostasis disturbance in rat with isoproterenol-induced myocardial injury.
Topics: Animals; Blotting, Western; Calcium; Cardiotonic Agents; Disease Models, Animal; Heart Diseases; Hea | 2012 |
Genistein prevents isoproterenol-induced cardiac hypertrophy in rats.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Catalase; Disease Models, Animal; Enzyme Inhibitors; Fibr | 2012 |
Granulocyte colony-stimulating factor improves early remodeling in isoproterenol-induced cardiac injury in rats.
Topics: Animals; Collagen; Dilatation, Pathologic; Disease Models, Animal; Echocardiography; Fibrosis; Granu | 2012 |
Turbinaria conoides (J. Agardh) sulfated polysaccharide protects rat's heart against myocardial injury.
Topics: Adenosine Triphosphatases; Animals; Calcium; Cell Membrane; Creatine Kinase; Disease Models, Animal; | 2012 |
Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog.
Topics: Animals; Arrhythmias, Cardiac; Atrioventricular Block; Benzylamines; Calcineurin; Calcium-Binding Pr | 2012 |
Adrenergic nerves govern circadian leukocyte recruitment to tissues.
Topics: Adrenergic Fibers; Adrenergic Neurons; Anemia, Sickle Cell; Animals; Bone Marrow; Bone Marrow Transp | 2012 |
Baroreflex control of renal sympathetic nerve activity in mice with cardiac hypertrophy.
Topics: Animals; Arterial Pressure; Baroreflex; Cardiomegaly; Disease Models, Animal; Isoproterenol; Kidney; | 2012 |
Efficacy of sesamol on plasma and tissue lipids in isoproterenol-induced cardiotoxicity in Wistar rats.
Topics: Animals; Antioxidants; Benzodioxoles; Disease Models, Animal; Dose-Response Relationship, Drug; Hypo | 2012 |
AAV-mediated knock-down of HRC exacerbates transverse aorta constriction-induced heart failure.
Topics: Animals; Aorta; Calcium; Calcium-Binding Proteins; Cardiomegaly; Carrier Proteins; Constriction; Cyt | 2012 |
Preconditioning with diosgenin and treadmill exercise preserves the cardiac toxicity of isoproterenol in rats.
Topics: Adrenergic beta-Agonists; Animals; Antioxidants; Diosgenin; Disease Models, Animal; Free Radicals; G | 2013 |
Anchored p90 ribosomal S6 kinase 3 is required for cardiac myocyte hypertrophy.
Topics: A Kinase Anchor Proteins; Adaptor Proteins, Signal Transducing; Animals; Animals, Newborn; Binding S | 2013 |
Preventive effects of Egyptian sweet marjoram (Origanum majorana L.) leaves on haematological changes and cardiotoxicity in isoproterenol-treated albino rats.
Topics: Animals; Blood Coagulation; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, | 2013 |
A mouse model reveals an important role for catecholamine-induced lipotoxicity in the pathogenesis of stress-induced cardiomyopathy.
Topics: Animals; Apolipoproteins B; Biopsy; Disease Models, Animal; Gene Expression Regulation; Humans; Isop | 2013 |
Further insights into the underlying electrophysiological mechanisms for reduction of atrial fibrillation by ranolazine in an experimental model of chronic heart failure.
Topics: Acetanilides; Acetylcholine; Animals; Atrial Fibrillation; Disease Models, Animal; Electrocardiograp | 2012 |
Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling.
Topics: Adrenergic beta-Antagonists; Animals; Apoptosis; Calcium; Calcium-Calmodulin-Dependent Protein Kinas | 2013 |
Activation of glibenclamide-sensitive ATP-sensitive K+ channels during β-adrenergically induced metabolic stress produces a substrate for atrial tachyarrhythmia.
Topics: Adrenergic beta-Agonists; Animals; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; G | 2012 |
Preventive effects of p-coumaric acid on lysosomal dysfunction and myocardial infarct size in experimentally induced myocardial infarction.
Topics: Animals; Antioxidants; Coumaric Acids; Disease Models, Animal; Free Radical Scavengers; Isoprotereno | 2013 |
Increased passive stiffness of cardiomyocytes in the transverse direction and residual actin and myosin cross-bridge formation in hypertrophied rat hearts induced by chronic β-adrenergic stimulation.
Topics: Actins; Adrenergic beta-Agonists; Animals; Cardiomegaly; Cells, Cultured; Diacetyl; Disease Models, | 2013 |
An increased TREK-1-like potassium current in ventricular myocytes during rat cardiac hypertrophy.
Topics: Animals; Benzofurans; Blotting, Western; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; | 2013 |
[The application of isoprenaline provocation test on rat model of alcoholic cardiomyopathy].
Topics: Animals; Cardiomyopathy, Alcoholic; Disease Models, Animal; Isoproterenol; Male; Rats; Rats, Sprague | 2012 |
(-) Epicatechin attenuates mitochondrial damage by enhancing mitochondrial multi-marker enzymes, adenosine triphosphate and lowering calcium in isoproterenol induced myocardial infarcted rats.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Biomarkers; Calcium; Catechin; Citric Acid Cycle; Cre | 2013 |
Downregulation of the cardiotrophin-1 gene expression by valsartan and spironolactone in hypertrophied heart rats in vivo and rat cardiomyocyte H9c2 cell line in vitro: a novel mechanism of cardioprotection.
Topics: Animals; Blotting, Western; Cardiomegaly; Cardiotonic Agents; Cell Line; Cytokines; Disease Models, | 2013 |
Novel rat model reveals important roles of β-adrenoreceptors in stress-induced cardiomyopathy.
Topics: Adrenergic beta-Agonists; Animals; Biopsy; Disease Models, Animal; Dose-Response Relationship, Drug; | 2013 |
Cardiac troponin T variants produced by aberrant splicing of multiple exons in animals with high instances of dilated cardiomyopathy.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Cardiomyopathy, Dilated; Cats; Cl | 2002 |
Autonomic control of the location and rate of the cardiac pacemaker in the sinoatrial fat pad of parasympathetically denervated dog hearts.
Topics: Adipose Tissue; Adrenergic beta-Agonists; Animals; Atropine; Autonomic Nervous System; Disease Model | 2002 |
Overexpression of Na+/Ca2+ exchanger gene attenuates postinfarction myocardial dysfunction.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Disease Models, Animal; Disease Progression; Electrocard | 2002 |
Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts. Role of phosphatases and response to isoproterenol.
Topics: Animals; Calcium; Calcium-Binding Proteins; Cyclic AMP-Dependent Protein Kinases; Disease Models, An | 2003 |
Characterisation of isoprenaline myotoxicity on slow-twitch skeletal versus cardiac muscle.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Isoproterenol | 2002 |
G-protein coupled receptor kinase 2 is altered during septic shock in rats.
Topics: Adrenergic beta-Agonists; Animals; beta-Adrenergic Receptor Kinases; Cyclic AMP-Dependent Protein Ki | 2002 |
Decreased beta-adrenergic responsiveness of Na/Ca exchange current in failing pig myocytes.
Topics: Adrenergic beta-Agonists; Animals; Disease Models, Animal; Enzyme Inhibitors; Heart Failure; Heart V | 2002 |
Overexpression of Na+/Ca2+ exchanger attenuates postinfarcted myocardial dysfunction.
Topics: Adrenergic beta-Agonists; Animals; Disease Models, Animal; Gene Expression Regulation; Hemodynamics; | 2002 |
Inhaled nitric oxide modifies left ventricular diastolic stress in the presence of vasoactive agents in heart failure.
Topics: Acetylcholine; Administration, Inhalation; Angiotensin II; Animals; Diastole; Disease Models, Animal | 2003 |
Exaggerated cardiovascular effects of cocaine in conscious dogs with pacing-induced dilated cardiomyopathy.
Topics: Adrenergic beta-Agonists; Animals; Baroreflex; Biomarkers; Cardiac Pacing, Artificial; Cardiomyopath | 2002 |
Abnormal contractile activity and calcium cycling in cardiac myocytes isolated from DMPK knockout mice.
Topics: Animals; Calcium; Disease Models, Animal; Heart; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Mice | 2003 |
Isolated heart responsiveness to beta-simulation after exercise training in obesity.
Topics: Adrenergic beta-Agonists; Animals; Disease Models, Animal; Exercise Therapy; Female; Humans; Isoprot | 2003 |
Impaired beta-adrenergic response and decreased L-type calcium current of hypertrophied left ventricular myocytes in postinfarction heart failure.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Calcium Channels, L-Type; Colforsin; Disease M | 2003 |
Changes of adrenomedullin and receptor activity modifying protein 2 (RAMP2) in myocardium and aorta in rats with isoproterenol-induced myocardial ischemia.
Topics: Adrenomedullin; Animals; Aorta; Disease Models, Animal; Heart; Intracellular Signaling Peptides and | 2003 |
Effect of D-003 on isoproterenol-induced myocardial necrosis in rats.
Topics: Animals; Aspirin; Disease Models, Animal; Fatty Acids; Isoproterenol; Male; Myocardial Infarction; M | 2003 |
Effect of L-arginine and L-lysine on lysosomal hydrolases and membrane bound phosphatases in experimentally induced myocardial infarction in rats.
Topics: Animals; Arginine; Cell Membrane; Disease Models, Animal; Hydrolases; Isoproterenol; Lysine; Lysosom | 2003 |
Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat.
Topics: Actin Cytoskeleton; Adrenergic beta-Agonists; Animals; Biomechanical Phenomena; Body Weight; Calcium | 2003 |
Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.
Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Catalytic Domain; Disease Models, Animal; Fibrosis; | 2003 |
Effects of triiodothyronine pretreatment on beta-adrenergic responses in stunned cardiac myocytes.
Topics: Adrenergic beta-Agonists; Animals; Cyclic AMP; Disease Models, Animal; Heart Ventricles; Isoproteren | 2003 |
Cardioprotective effect of the alcoholic extract of Terminalia arjuna bark in an in vivo model of myocardial ischemic reperfusion injury.
Topics: Administration, Oral; Animals; Catalase; Disease Models, Animal; Dose-Response Relationship, Drug; G | 2003 |
Effects of in vivo treatment with interleukins 1beta and 6 on rat mesenteric vascular bed reactivity.
Topics: Acetylcholine; Animals; Arginine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Syn | 2003 |
Anterior hypothalamic beta-adrenergic activity in the maintenance of hypertension in aortic coarctated rats.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Anterior Hypothalamic Nucleus; Aorti | 2004 |
Depressed contractile function and adrenergic responsiveness of cardiac myocytes in an experimental model of Parkinson disease, the MPTP-treated mouse.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding Sites; Caffeine; Calcium; Cell Size; | 2004 |
Potassium canrenoate, an aldosterone receptor antagonist, reduces isoprenaline-induced cardiac fibrosis in the rat.
Topics: Animals; Blood Pressure; Canrenoic Acid; Cardiomyopathies; Disease Models, Animal; Dose-Response Rel | 2004 |
Changes in the vascular beta-adrenoceptor-activated signalling pathway in 2Kidney-1Clip hypertensive rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta, Thoracic; Caffeine; Calcium-Transporting ATP | 2004 |
Increased tracheal responsiveness to beta-adrenergic agonist and antagonist in ovalbumin-sensitized guinea pigs.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aerosols; Animals | 2004 |
Improvement of cardiac function and beta-adrenergic signal transduction by propionyl L-carnitine in congestive heart failure due to myocardial infarction.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiotonic Agent | 2004 |
Comparative account of certain enzymes in the serum of homo-iothermal vertebrates subjected to production of myocardial infarction by isoproterenol hydrochloride.
Topics: Acetylcholinesterase; Alanine Transaminase; Animals; Aspartate Aminotransferases; Columbidae; Diseas | 2003 |
Decreased baroreflex sensitivity in isoproterenol-treated mice with cardiac hypertrophy.
Topics: Animals; Baroreflex; Blood Pressure; Body Weight; Bronchodilator Agents; Cardiomegaly; Disease Model | 2004 |
Treatment of acute myocardial infarction by hepatocyte growth factor gene transfer: the first demonstration of myocardial transfer of a "functional" gene using ultrasonic microbubble destruction.
Topics: Animals; Capillaries; Cicatrix; Disease Models, Animal; Gene Expression Regulation; Gene Transfer Te | 2004 |
Furosemide and the progression of left ventricular dysfunction in experimental heart failure.
Topics: Adrenergic beta-Agonists; Aldosterone; Animals; Biomarkers; Disease Models, Animal; Disease Progress | 2004 |
Measuring transient systemic conductance and capacitance responses using a modified Brooksby-Donald technique in anesthetized, autonomically intact rabbits.
Topics: Analysis of Variance; Animals; Blood Flow Velocity; Disease Models, Animal; Female; Injections, Intr | 2004 |
Changes in beta-adrenoceptors in heart failure due to myocardial infarction are attenuated by blockade of renin-angiotensin system.
Topics: Adenylyl Cyclases; Angiotensin-Converting Enzyme Inhibitors; Animals; Disease Models, Animal; Enalap | 2004 |
Myocardial infarction non-invasively induced in rabbits by administering isoproterenol and vasopressin: protective effects exerted by verapamil.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Disease Models, Animal; Electrocardiography; Hear | 2004 |
Salivary secretion assay for drug efficacy for cystic fibrosis in mice.
Topics: Acetylcholine; Animals; Cystic Fibrosis; Disease Models, Animal; Drug Evaluation, Preclinical; Isopr | 2005 |
Correlation of behavior changes and BOLD signal in Alzheimer-like rat model.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Hippocampus; Isoproterenol; Magnetic Resonance I | 2004 |
Down-regulation of Na+ pump alpha 2 isoform in isoprenaline-induced cardiac hypertrophy in rat: evidence for increased receptor binding affinity but reduced inotropic potency of digoxin.
Topics: Animals; Digoxin; Disease Models, Animal; Down-Regulation; Hypertrophy, Left Ventricular; Isoprotere | 2005 |
Protective effects of dantrolene against myocardial injury induced by isoproterenol in rats: biochemical and histological findings.
Topics: Adrenergic beta-Agonists; Animals; Dantrolene; Disease Models, Animal; Heart; Isoproterenol; Male; M | 2005 |
Repeated daily injections and osmotic pump infusion of isoproterenol cause similar increases in cardiac mass but have different effects on blood pressure.
Topics: Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Infusion Pumps; Infusions, Intravenou | 2005 |
Sex modulates the arrhythmogenic substrate in prepubertal rabbit hearts with Long QT 2.
Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Fe | 2005 |
Cellular mechanisms underlying the development of catecholaminergic ventricular tachycardia.
Topics: Action Potentials; Animals; Caffeine; Calcium; Catecholamines; Disease Models, Animal; Dogs; Dose-Re | 2005 |
Limited additional release of cardiac troponin I and T in isoproterenol-treated beagle dogs with cardiac injury.
Topics: Adrenergic beta-Agonists; Animals; Biomarkers; Creatine Kinase; Disease Models, Animal; Dogs; Female | 2005 |
Comparison of muscarinic receptor- and beta-adrenoceptor-mediated vasorelaxation between euthyroid and acute hyperthyroid rats.
Topics: Acetylcholine; Adrenergic beta-Agonists; Animals; Aorta, Thoracic; Disease Models, Animal; Dose-Resp | 2005 |
Agonist-independent alteration in beta-adrenoceptor-G-protein-adenylate cyclase system in an equine model of recurrent airway obstruction.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Airway Obstruction; Animal | 2006 |
Effect of relaxin on myocardial ischemia injury induced by isoproterenol.
Topics: Animals; Cardiomegaly; Creatine Kinase; Disease Models, Animal; Endothelins; Gene Expression; Heart; | 2005 |
Animal models of cardiac fibrosis.
Topics: Aldosterone; Angiotensin II; Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Heart Diseases; | 2005 |
Enhanced inhibition of L-type Ca2+ current by beta3-adrenergic stimulation in failing rat heart.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Calcium Channels, L-Type; Disease Mo | 2005 |
Mechanisms of preserved baseline cardiac systolic function in rats with adrenergic inotropic downregulation.
Topics: Adrenergic beta-Agonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Re | 2005 |
Contribution of cytochrome P450 metabolites of arachidonic acid to hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME.
Topics: Animals; Arachidonic Acid; Blood Pressure; Blood Vessels; Collagen Type III; Coronary Vessels; Cytoc | 2005 |
[PTEN negatively regulates isoproterenol-induced cardiac hypertrophy and effects of captopril on PTEN expression].
Topics: Animals; Captopril; Cardiomegaly; Disease Models, Animal; Gene Expression Regulation; Isoproterenol; | 2005 |
Contribution of endogenous opioids and nitric oxide to papillary muscle contractile impairment in cholestatic rats.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Analysis of Variance; Animals; Bile Ducts; Card | 2005 |
Induction of heparanase gene expression in ventricular myocardium of rats with isoproterenol-induced cardiac hypertrophy.
Topics: Animals; Blotting, Northern; Cardiomegaly; Disease Models, Animal; Drug Administration Schedule; Enz | 2005 |
Relative toxicity of cardiotonic agents: some induce more cardiac and skeletal myocyte apoptosis and necrosis in vivo than others.
Topics: Animals; Apoptosis; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; He | 2005 |
Trimetazidine improved Ca2+ handling in isoprenaline-mediated myocardial injury of rats.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Signaling; Cardiomyopathies; Cardiotonic Agents; D | 2006 |
Heart failure reduces both the effects and interaction between cyclic GMP and cyclic AMP.
Topics: Animals; Cardiac Output, Low; Cardiotonic Agents; Coronary Circulation; Coronary Vessels; Cyclic AMP | 2006 |
Effect of mangiferin on mitochondrial energy production in experimentally induced myocardial infarcted rats.
Topics: Animals; Antioxidants; Blood Glucose; Disease Models, Animal; Energy Metabolism; Glutathione; Isopro | 2006 |
Cardioprotective effect of grape seed proanthocyanidins on isoproterenol-induced myocardial injury in rats.
Topics: Animals; Biomarkers; Biopsy, Needle; Blood Chemical Analysis; Cardiotonic Agents; Disease Models, An | 2007 |
Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Benzylamines; Brain; C | 2007 |
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma.
Topics: Animals; Carcinoma; Cell Line, Tumor; Disease Models, Animal; Drug Combinations; Enzyme Inhibitors; | 2006 |
Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Apoptosis; Arrhythmias, Cardiac; Benzylamines; Calci | 2006 |
Cardioprotective effect of the Hibiscus rosa sinensis flowers in an oxidative stress model of myocardial ischemic reperfusion injury in rat.
Topics: Administration, Oral; Animals; Antioxidants; Catalase; Disease Models, Animal; Flowers; Glutathione; | 2006 |
Pharmacokinetics and pharmacodynamics of bisoprolol in rats with bilateral ureter ligation-induced renal failure.
Topics: Acute Kidney Injury; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Analysis of Variance; An | 2006 |
Maintaining serum response factor activity in the older heart equal to that of the young adult is associated with better cardiac response to isoproterenol stress.
Topics: Age Factors; Animals; Blotting, Western; Disease Models, Animal; Gene Expression Regulation; Heart; | 2007 |
Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block.
Topics: Adrenergic beta-Agonists; Animals; Buffers; Calcium; Calcium Channels, L-Type; Cardiomegaly; Chronic | 2007 |
Extracellular signal-regulated kinase pathway is differentially involved in beta-agonist-induced hypertrophy in slow and fast muscles.
Topics: Adrenergic beta-Agonists; Animals; Cell Cycle Proteins; Cell Line; Clenbuterol; Disease Models, Anim | 2007 |
The myocardial response to adrenomedullin involves increased cAMP generation as well as augmented Akt phosphorylation.
Topics: Adrenomedullin; Animals; Blotting, Western; Calcitonin Receptor-Like Protein; Cardiotonic Agents; Cy | 2007 |
Muscarinic modulation of the sodium-calcium exchanger in heart failure.
Topics: Adrenergic beta-Agonists; Animals; Carbachol; Cardiac Pacing, Artificial; Cell Separation; Cells, Cu | 2007 |
Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis.
Topics: Actin Cytoskeleton; Adrenergic beta-Agonists; Animals; Calcium; Cardiomyopathy, Hypertrophic, Famili | 2007 |
Lovastatin specifically prevents focal ischemic ventricular tachycardia due to triggered activity.
Topics: Action Potentials; Adrenergic beta-Agonists; Analysis of Variance; Animals; Anti-Arrhythmia Agents; | 2007 |
Increased expression of endothelial nitric oxide synthase and caveolin-1 in the aorta of rats with isoproterenol-induced cardiac hypertrophy.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Cardiomegaly; Caveolin 1; Disease Models, Animal; Dos | 2006 |
Effects of a novel histone deacetylase inhibitor, N-(2-aminophenyl) benzamide, on a reversible hypertrophy induced by isoproterenol in in situ rat hearts.
Topics: Analysis of Variance; Animals; Benzamides; Cardiac Catheterization; Cardiac Output; Cardiomegaly; Co | 2007 |
Temporal changes in myocardial adrenergic regulation with the progression to pump dysfunction after chronic beta-adrenoreceptor activation in rats.
Topics: Adrenergic beta-Agonists; Animals; Disease Models, Animal; Heart Ventricles; Isoproterenol; Male; My | 2007 |
Cerebroprotective effects of the CO-releasing molecule CORM-A1 against seizure-induced neonatal vascular injury.
Topics: Administration, Topical; Animals; Animals, Newborn; Bicuculline; Blood Pressure; Boranes; Bradykinin | 2007 |
Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice.
Topics: Animals; Calbindin 2; Calcium; Calcium Channels; Calcium Signaling; Calsequestrin; Cardiac Pacing, A | 2007 |
Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Calcium Channels, L-Type; Calcium Signaling; C | 2007 |
In vivo mechanisms precipitating torsades de pointes in a canine model of drug-induced long-QT1 syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium; Chromans; Disease Models, Animal; Dogs; | 2007 |
Isoproterenol-induced impairment of heart function and remodeling are attenuated by the nonpeptide angiotensin-(1-7) analogue AVE 0991.
Topics: Angiotensins; Animals; Cardiomegaly; Collagen; Disease Models, Animal; Extracellular Matrix; Fibrone | 2007 |
Drug-induced torsades de pointes--a form of mechano-electric feedback?
Topics: Action Potentials; Animals; Disease Models, Animal; Dogs; Electrocardiography; Feedback, Physiologic | 2007 |
Linking calsequestrin to lumenal control of SR Ca2+ release.
Topics: Animals; Calbindin 2; Calcium; Calcium Channels; Calcium Signaling; Calsequestrin; Cardiac Pacing, A | 2007 |
Susceptibility to systolic dysfunction in the myocardium from chronically infarcted spontaneously hypertensive rats.
Topics: Animals; Apoptosis; Cardiotonic Agents; Coronary Vessels; Disease Models, Animal; Hypertension; Isop | 2008 |
In vitro sensitivity of mouse esophagus to agonists in different pH medium values.
Topics: Acetylcholine; Adrenergic beta-Agonists; Analysis of Variance; Animals; Carbachol; Cholinergic Agoni | 2007 |
Doxycycline attenuates isoproterenol- and transverse aortic banding-induced cardiac hypertrophy in mice.
Topics: Animals; Aorta; Cardiomegaly; Disease Models, Animal; Doxycycline; Isoproterenol; Male; Mice; Mice, | 2008 |
Exercise promotes angiogenesis and improves beta-adrenergic receptor signalling in the post-ischaemic failing rat heart.
Topics: Adrenergic beta-Agonists; Animals; Coronary Circulation; Coronary Vessels; Disease Models, Animal; D | 2008 |
Comparison of the cardioprotective effects of cardos and losartan in rats with experimental chronic cardiac insufficiency.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antibodies; Cardiotonic Agents; Chronic Disease; D | 2007 |
Effects of diesel exhaust particles on left ventricular function in isoproterenol-induced myocardial injury and healthy rats.
Topics: Air Pollutants; Animals; Disease Models, Animal; Drug Synergism; Electrocardiography; Heart; Intubat | 2008 |
Decreased NO signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertension.
Topics: Animals; Arterioles; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Disease Models, Anima | 2008 |
Mice lacking the transient receptor vanilloid potential 1 channel display normal thirst responses and central Fos activation to hypernatremia.
Topics: Adrenergic beta-Agonists; Animals; Blood Proteins; Disease Models, Animal; Diuretics; Drinking; Furo | 2008 |
Preventive effect of (-)epigallocatechin-gallate (EGCG) on lysosomal enzymes in heart and subcellular fractions in isoproterenol-induced myocardial infarcted Wistar rats.
Topics: Animals; Cardiovascular Agents; Catechin; Disease Models, Animal; Heart; Isoproterenol; Lysosomes; M | 2008 |
Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification.
Topics: Adrenergic beta-Agonists; Animals; Calcinosis; Calcium-Binding Proteins; Cardiomyopathies; Cell Adhe | 2008 |
Isoproterenol-induced cardiotoxicity in sprague-dawley rats: correlation of reversible and irreversible myocardial injury with release of cardiac troponin T and roles of iNOS in myocardial injury.
Topics: Adrenergic beta-Antagonists; Animals; Apoptosis; Cell Count; Disease Models, Animal; Dose-Response R | 2008 |
Electrocardiography in two models of isoproterenol-induced left ventricular remodeling.
Topics: Action Potentials; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiog | 2008 |
Protective role of curcumin in myocardial oxidative damage induced by isoproterenol in rats.
Topics: Adrenergic beta-Agonists; Alanine Transaminase; Animals; Aspartate Aminotransferases; Cardiotonic Ag | 2007 |
[Autologous sinoatrial node cells heterotopic transplantation for treating bradycardia: an experiment with dogs].
Topics: Animals; Atropine; Bradycardia; Bronchodilator Agents; Cell Survival; Cell Transplantation; Connexin | 2007 |
Alterations in the mechanical properties of bladder smooth muscle in hydrocephalus rat model.
Topics: Adrenergic beta-Agonists; Animals; Biomechanical Phenomena; Disease Models, Animal; Dose-Response Re | 2008 |
Temporal gene expression profiling indicates early up-regulation of interleukin-6 in isoproterenol-induced myocardial necrosis in rat.
Topics: Adrenergic beta-Agonists; Animals; Disease Models, Animal; Gene Expression Profiling; Heart; Injecti | 2008 |
Reduced levels of cyclic AMP contribute to the enhanced oxidative stress in vascular smooth muscle cells from spontaneously hypertensive rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Angiotensin II; Animals; Cell Line; Cells | 2008 |
Isoproterenol-induced hypertrophied rat hearts: does short-term treatment correspond to long-term treatment?
Topics: Animals; Blood Pressure; Blotting, Western; Cardiac Volume; Cardiotonic Agents; Disease Models, Anim | 2008 |
Protective effect of the endothelin antagonist CPU0213 against isoprenaline-induced heart failure by suppressing abnormal expression of leptin, calcineurin and SERCA2a in rats.
Topics: Animals; Calcineurin; Cardiotonic Agents; Disease Models, Animal; Endothelin Receptor Antagonists; E | 2008 |
Islet secretion in a new experimental model for non-insulin-dependent diabetes.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Glucagon; Glucos | 1981 |
[Effect of central effective substances on alcohol preference].
Topics: Alcohol Drinking; Alcoholism; Animals; Arecoline; Atropine; Central Nervous System Stimulants; Cypro | 1983 |
The effects of Haemophilus influenzae vaccination on anaphylactic mediator release and isoprenaline-induced inhibition of mediator release.
Topics: Anaphylaxis; Animals; Arachidonic Acids; Asthma; Autacoids; Bradykinin; Bronchial Spasm; Disease Mod | 1980 |
Some functional changes in experimentally induced cardiac overload.
Topics: Aminooxyacetic Acid; Animals; Atropine; Cardiomegaly; Disease Models, Animal; Drug Combinations; Ele | 1983 |
Increased pulmonary alpha-adrenergic and reduced beta-adrenergic receptors in experimental asthma.
Topics: Adenylyl Cyclases; Animals; Asthma; Dihydroalprenolol; Disease Models, Animal; Enzyme Activation; Gu | 1980 |
Changes in beta adrenergic receptors in submaxillary glands of chronically reserpine- or isoproterenol-treated rats.
Topics: Animals; Cystic Fibrosis; Disease Models, Animal; Feedback; Isoproterenol; Kinetics; Nucleotidases; | 1981 |
Impairment of hormone-stimulated cardiac adenylate cyclase activity in the genetically obese (fa/fa) Zucker rat.
Topics: Adenylyl Cyclases; Age Factors; Animals; Disease Models, Animal; Enzyme Activation; Food Deprivation | 1981 |
An overall review on prenylamine mechanisms of action in experimental models of myocardial damage.
Topics: Angina Pectoris; Animals; Calcium; Cebus; Disease Models, Animal; Electrocardiography; Female; Heart | 1982 |
Beta-adrenoceptors and responsiveness in cardiac hypertrophy associated with renal hypertension in renovascular hypertensive rats.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Dose-Response Relationship, Drug; Heart; Heart Rate; | 1984 |
Experimental observations on peritoneal transport in rabbits.
Topics: Animals; Biological Transport; Creatinine; Disease Models, Animal; Dopamine; Fenoterol; Inulin; Isop | 1983 |
[Behavior of adenylate cyclase in ischemic and necrotic myocardial tissue].
Topics: Adenylyl Cyclases; Animals; Coronary Disease; Disease Models, Animal; Histocytochemistry; Isoprotere | 1984 |
Myocardial hypertrophy in the rat. Correlation between two experimental models.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Heart; Hypoxia; Isoproterenol; Male; Myocardial Infar | 1980 |
Blood flow in the hypertrophied right ventricular myocardium of unanesthetized ponies.
Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Coronary Circulation; Disease Models, Animal; He | 1981 |
Effects of atrial pacing, isoprenaline and lignocaine on experimental polymorphous ventricular tachycardia.
Topics: Animals; Blood Pressure; Cardiac Pacing, Artificial; Disease Models, Animal; Dogs; Electrocardiograp | 1984 |
Pulmonary function of the reserpine and isoproterenol models of cystic fibrosis.
Topics: Airway Resistance; Animals; Cystic Fibrosis; Disease Models, Animal; Isoproterenol; Lung Volume Meas | 1984 |
[Adaptative cardiac changes in arterial hypertension].
Topics: Adaptation, Physiological; Animals; Blood Pressure; Cell Membrane; Disease Models, Animal; Heart Rat | 1984 |
A canine model of transient myocardial dysfunction regional shortening in the presence of critical stenosis and cardiac stimulation.
Topics: Anesthesia; Angina Pectoris; Animals; Blood Pressure; Coronary Circulation; Coronary Vessels; Diseas | 1984 |
[A model for anaphylactic asthma in dogs and the effects of isoproterenol].
Topics: Animals; Antigens; Ascaris; Asthma; Disease Models, Animal; Dogs; Female; Isoproterenol; Male | 1983 |
The chronically isoproterenol-treated rat in the study of cystic fibrosis: X-ray microanalysis of the submandibular gland.
Topics: Animals; Calcium; Cystic Fibrosis; Disease Models, Animal; Drug Interactions; Electron Probe Microan | 1984 |
Detection of acute myocardial infarction in spontaneously hypertensive rats by 99mTc-pyrrolidino methyl tetracycline.
Topics: Animals; Disease Models, Animal; Female; Hypertension; Isoproterenol; Male; Myocardial Infarction; M | 1983 |
Responsiveness of isolated tracheal smooth muscle in a canine model of asthma.
Topics: Animals; Antigens; Asthma; Disease Models, Animal; Dogs; In Vitro Techniques; Isoproterenol; Methach | 1982 |
Changes in glycoproteins in isoproterenol-induced myocardial infarction in rats.
Topics: Animals; Disease Models, Animal; Glycoproteins; Isoproterenol; Male; Myocardial Infarction; Myocardi | 1982 |
Effect of oxyfedrine on myocardial glycolytic flux during ischaemia in rats.
Topics: Animals; Coronary Disease; Disease Models, Animal; Female; Glycolysis; Heart; Isoproterenol; Male; M | 1980 |
Development of a severe model of early coronary artery ligation-induced dysrhythmias in the anaesthetized rat.
Topics: Androstanols; Angiotensin II; Animals; Arrhythmias, Cardiac; Atropine; Catecholamines; Coronary Vess | 1981 |
Effect of perhexilene on 86Rb uptake in experimental myocardial infarction.
Topics: Animals; Biological Transport, Active; Disease Models, Animal; Female; Heart; Isoproterenol; Male; M | 1981 |
Composition of pulmonary lavage fluid in control and reserpine-treated rats following chronic isoproterenol and pilocarpine administration.
Topics: Animals; Body Fluids; Carbohydrates; Cystic Fibrosis; Disease Models, Animal; Isoproterenol; Lipids; | 1980 |
Detection of latent coronary stenosis in conscious dogs: regional functional and electrocardiographic responses to isoprenaline.
Topics: Animals; Coronary Disease; Disease Models, Animal; Dogs; Electrocardiography; Heart; Isoproterenol | 1980 |
[Importance of microcirculation in myocardial circulatory disorders].
Topics: Animals; Capillaries; Coronary Circulation; Coronary Disease; Coronary Vessels; Disease Models, Anim | 1980 |
Functional characteristics of atrophic parotid acinar cells from rats after liquid feeding.
Topics: Amylases; Animals; Atrophy; Chlorides; Disease Models, Animal; Exocytosis; Food, Formulated; Ion Tra | 1994 |
Mechanisms of cardiac cell damage due to catecholamines: significance of drugs regulating central sympathetic outflow.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; Calcium; Catecholamines; Clo | 1994 |
Changes in sympathetic neurotransmission and adrenergic control of cardiac contractility during 1,3-dipropyl-8-sulfophenylxanthine-induced hypertension.
Topics: Adenosine; Adrenergic beta-Agonists; Animals; Calcium; Cardiotonic Agents; Depression, Chemical; Dis | 1995 |
Desensitization of myocardial beta-adrenergic receptors and deterioration of left ventricular function after brain death.
Topics: Adenylyl Cyclases; Animals; Brain Death; Colforsin; Cyclic AMP; Disease Models, Animal; GTP-Binding | 1995 |
Cell deletion by apoptosis during regression of rat parotid sialadenosis.
Topics: Animals; Apoptosis; Disease Models, Animal; Isoproterenol; Male; Mitotic Index; Organ Size; Parotid | 1995 |
Relation between myocardial beta-adrenoceptor density and hemodynamic and neurohumoral changes in a rat model of chronic myocardial infarction: effects of ibopamine and captopril.
Topics: Adrenergic beta-Agonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Chronic Dise | 1995 |
Cardiac hypertrophy induced by alpha- and beta-adrenergic receptor stimulation.
Topics: Animals; Disease Models, Animal; Female; Glucosephosphate Dehydrogenase; Hemodynamics; Hypertrophy, | 1995 |
The effect of flunarizine and ryanodine on acquired torsades de pointes arrhythmias in the intact canine heart.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Channels; Disease Models, Animal; Dogs; | 1995 |
Parathyroid hormone (PTH)/PTH-related protein receptor messenger ribonucleic acid expression and PTH response in a rat model of secondary hyperparathyroidism associated with vitamin D deficiency.
Topics: Adenylyl Cyclases; Animals; Calcium; Cell Membrane; Colforsin; Diaphyses; Disease Models, Animal; Fe | 1995 |
Bovine hereditary cardiomyopathy: an animal model of human dilated cardiomyopathy.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cardiomyopathies; Cardiomyopathy, Dilated; Cate | 1995 |
Distinct modulation of myocardial performance, energy metabolism, and [Ca2+]i transients by positive inotropic drugs in normal and severely failing hamster hearts.
Topics: Amrinone; Animals; Blood Pressure; Bucladesine; Calcium; Cardiomyopathies; Cardiotonic Agents; Crice | 1995 |
Transition from compensatory hypertrophy to dilated, failing left ventricles in Dahl salt-sensitive rats.
Topics: Animals; Blood Pressure; Calcium; Cardiomegaly; Disease Models, Animal; Echocardiography; Heart Fail | 1994 |
Anti-arrhythmic profile of a garlic dialysate assayed in dogs and isolated atrial preparations.
Topics: Aconitine; Animals; Arrhythmias, Cardiac; Dialysis; Disease Models, Animal; Dogs; Dose-Response Rela | 1994 |
Effects of beta-blockers and Ca(2+)-antagonists on the response of the isolated working rat heart to adrenergic stimulants after cardioplegic arrest.
Topics: Adenine Nucleotides; Animals; Cardiac Output; Cardiotonic Agents; Disease Models, Animal; Dobutamine | 1993 |
Adrenoceptor-linked [45Ca2+] uptake in platelets from diabetic rats: a model for human platelets.
Topics: Animals; Blood Platelets; Calcium; Calcium Radioisotopes; Diabetes Mellitus, Experimental; Disease M | 1994 |
Effects of metoprolol on left ventricular function in rats with myocardial infarction.
Topics: Animals; Blood Pressure; Coronary Vessels; Diastole; Disease Models, Animal; Dose-Response Relations | 1994 |
Elevated lung G protein levels and muscarinic receptor affinity in a mouse model of airway hyperreactivity.
Topics: Animals; Binding, Competitive; Bronchial Hyperreactivity; Cell Membrane; Dihydroalprenolol; Disease | 1993 |
Regional myocardial downregulation of the inhibitory guanosine triphosphate-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model of chronic episodic myocardial ischemia.
Topics: Adenylyl Cyclases; Animals; Base Sequence; Cell Membrane; Coronary Circulation; Disease Models, Anim | 1993 |
Effect of KRN2391, a novel vasodilator, on various experimental anginal models in rats.
Topics: Angina Pectoris; Animals; Disease Models, Animal; Electrocardiography; Injections, Intravenous; Isop | 1993 |
Pathophysiological and biochemical characterisation of an avian model of dilated cardiomyopathy: comparison to findings in human dilated cardiomyopathy.
Topics: Adenosine Triphosphatases; Animals; Calcium; Cardiomyopathy, Dilated; Culture Techniques; Disease Mo | 1993 |
Preliminary evaluation of a series of amphiphilic timolol prodrugs: possible evidence for transscleral absorption.
Topics: Absorption; Animals; Cell Membrane Permeability; Cornea; Disease Models, Animal; Esters; Evaluation | 1993 |
Hypoxia enhances isoproterenol-induced increase in heart interstitial adenosine, depressing beta-adrenergic contractile responses.
Topics: Adenosine; Animals; Cell Hypoxia; Disease Models, Animal; Heart; Isoproterenol; Male; Myocardial Con | 1993 |
Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Animals; Asthma; Bronchodilator Agents; Cyclic Nuc | 1993 |
Cardiac beta-adrenoceptors, G-proteins and adenylate cyclase regulation during myocardial hypertrophy.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Carbachol; Cardiomegaly; Cholera Toxin; Colfors | 1993 |
Impaired beta-adrenergic receptor activation of adenylyl cyclase in airway smooth muscle in the basenji-greyhound dog model of airway hyperresponsiveness.
Topics: Adenylyl Cyclases; Analysis of Variance; Animals; Bronchial Hyperreactivity; Bucladesine; Cholera To | 1993 |
Analysis of responses to pentoxifylline in the pulmonary vascular bed of the cat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Arginine | 1996 |
Hemodynamic effects of intravenous isoproterenol versus epinephrine in the chronic maternal-fetal sheep preparation.
Topics: Acid-Base Equilibrium; Adrenergic beta-Agonists; Amniotic Fluid; Animals; Blood Pressure; Cardiac Ou | 1996 |
Triggered activity as a mechanism for inherited ventricular arrhythmias in German shepherd Dogs.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Arrhythmias, Cardiac; Disease Models, | 1996 |
Impaired activation of adenylyl cyclase in lung of the Basenji-greyhound model of airway hyperresponsiveness: decreased numbers of high affinity beta-adrenoceptors.
Topics: Adenylyl Cyclases; Animals; Asthma; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; | 1996 |
Spinal somatosensory evoked potentials after epidural isoproterenol in awake sheep.
Topics: Adrenergic beta-Agonists; Anesthesia, Epidural; Anesthetics, Local; Animals; Disease Models, Animal; | 1997 |
Differential regulation of natriuretic peptide genes in infarcted rat hearts.
Topics: Animals; Atrial Natriuretic Factor; Creatine Kinase; Disease Models, Animal; Gene Expression Regulat | 1997 |
Coronary artery stenosis in rats affects beta-adrenergic receptor signaling in myocytes.
Topics: Adrenergic beta-Agonists; Animals; Binding Sites; Binding, Competitive; Cell Membrane; Coronary Dise | 1997 |
Increased cardiac workload by adrenoceptor agonists for the estimation of potential antiischemic activity in a conscious rabbit model.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Cardiac Pacing, Artificial; Disease Mo | 1997 |
Role of beta-adrenoceptors in gastric mucosal integrity and gastroprotection induced by epidermal growth factor.
Topics: Adrenalectomy; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Clonidine; Culture Tech | 1997 |
Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer.
Topics: Adenoviridae; Animals; beta-Adrenergic Receptor Kinases; Cyclic AMP; Cyclic AMP-Dependent Protein Ki | 1997 |
Characterisation of a cellular model of cardiomyopathy, in the rabbit, produced by chronic administration of the anthracycline, epirubicin.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Electrophysiology; Epirubicin; Heart; Heart Fai | 1997 |
Allylamine and beta-aminopropionitrile-induced vascular injury: enhanced expression of high-molecular-weight proteins.
Topics: Administration, Oral; Allylamine; Aminopropionitrile; Animals; Aorta; Collagen; Disease Models, Anim | 1998 |
Development of heart failure following isoproterenol administration in the rat: role of the renin-angiotensin system.
Topics: Adrenergic beta-Agonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Disease Models, Animal; | 1998 |
Temporal relation of ATP-sensitive potassium-channel activation and contractility before cardioplegia.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Cardioplegic Solutions; Cardiotonic Agent | 1998 |
New in situ mouse model to quantify alveolar epithelial fluid clearance.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Amiloride; Animals; Atenolol; Bronchoalveolar | 1998 |
Effect of left ventricular sphericity on the evolution of ventricular dysfunction in rats with diffuse isoproterenol-induced myocardial necrosis.
Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Cardiac Output; Cardiomyopathies; Disease M | 1998 |
Involvement of IsK-associated K+ channel in heart rate control of repolarization in a murine engineered model of Jervell and Lange-Nielsen syndrome.
Topics: Aging; Animals; Blotting, Northern; Cardiotonic Agents; Cells, Cultured; Disease Models, Animal; Ele | 1998 |
Effect of a novel tetrapeptide derivative in a model of isoproterenol induced myocardial necrosis.
Topics: Adrenergic beta-Agonists; Animals; Aspirin; Body Weight; Creatine Kinase; Disease Models, Animal; Fe | 1998 |
Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: effects of beta-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Dogs; Dose-R | 1998 |
Effects of cyclic adenosine monophosphate (cAMP) on sarcoplasmic reticulum Ca(2+)-loading in failing rabbit and human cardiac trabeculae.
Topics: Actin Cytoskeleton; Adrenergic beta-Agonists; Animals; Caffeine; Calcium; Coronary Circulation; Cycl | 1998 |
The myocardial beta-adrenergic system in spontaneously hypertensive heart failure (SHHF) rats.
Topics: Aging; Animals; beta-Adrenergic Receptor Kinases; Cyclic AMP-Dependent Protein Kinases; Disease Mode | 1999 |
An in vivo model of beta-adrenoceptor desensitization.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Animals; Asthma; Bronchoconstrictor | 1998 |
Tritiated thymidine and bromodeoxyuridine double-labelling studies on growth factors and oral epithelial proliferation in the mouse.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Antimetabolites; Bromodeoxyuridine; Ca | 1999 |
Inducible nitric oxide synthase and tumor necrosis factor in animal models of myocardial necrosis induced by coronary artery ligation or isoproterenol injection.
Topics: Animals; Biomarkers; Blotting, Northern; Coronary Vessels; Disease Models, Animal; Heart Ventricles; | 1999 |
Noninvasive evaluation of cardiac dysfunction by echocardiography in streptozotocin-induced diabetic rats.
Topics: Animals; Cardiomyopathies; Cardiotonic Agents; Diabetes Mellitus, Experimental; Disease Models, Anim | 1999 |
Transgenic mouse model of stunned myocardium.
Topics: Actin Cytoskeleton; Adrenergic beta-Agonists; Animals; Calcium; Cardiomegaly; Dilatation, Pathologic | 2000 |
Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome.
Topics: Action Potentials; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiotonic Agent | 2000 |
Down regulation of myocardial beta1-adrenoceptor signal transduction system in pacing-induced failure in dogs with aortic stenosis-induced left ventricular hypertrophy.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Adrenergic beta-Agonists; Analysis of Varian | 2000 |
Remodelling of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing calsequestrin.
Topics: Action Potentials; Animals; Calcium Channels, L-Type; Calcium Signaling; Calsequestrin; Cardiomegaly | 2000 |
The effects of high-dose epinephrine combined with isoprenaline on isolated rabbit heart and cardiomyocytes after cardioversion of ventricular fibrillation.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Calcium Channels, L-Type; Disease Models, Anim | 2000 |
Cardiac excitation-contraction coupling in the portal hypertensive rat.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |
[Hemodynamic consequences of endogenous hyperinsulinism in obese rats with lesions of the ventromedial hypothalamus].
Topics: Adrenergic Agonists; Adrenergic beta-Agonists; Animals; Atropine; Baroreflex; Blood Pressure; Bradyc | 2000 |
Selegiline improves cardiac sympathetic terminal function and beta-adrenergic responsiveness in heart failure.
Topics: Analysis of Variance; Animals; Baroreflex; Binding Sites; Cardiac Pacing, Artificial; Disease Models | 2000 |
Protein phosphatase activity is increased in a rat model of long-term beta-adrenergic stimulation.
Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Calcium-Binding Proteins; Cardiomegaly; Dis | 2000 |
Comparison of bisoprolol and carvedilol cardioprotection in a rabbit ischemia and reperfusion model.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Antioxidants; Bisoprolol; Carbazoles | 2000 |
Altered beta-adrenergic signal transduction in nonfailing hypertrophied myocytes from Dahl salt-sensitive rats.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Calcium; Calcium Chan | 2000 |
Ischemic inactivation of G protein-coupled receptor kinase and altered desensitization of canine cardiac beta-adrenergic receptors.
Topics: Adenylyl Cyclases; Animals; beta-Adrenergic Receptor Kinases; Binding, Competitive; Blotting, Wester | 2000 |
Dyssynchronous Ca(2+) sparks in myocytes from infarcted hearts.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Calcium; Calcium Channels, L-Type; Calcium Sig | 2000 |
Effect of SMP-300, a new Na+/H+ exchange inhibitor, on myocardial ischemia and experimental angina models in rats.
Topics: Amiloride; Angina Pectoris; Animals; Azocines; Blood Pressure; Disease Models, Animal; Electrocardio | 2000 |
Reduction in myocardial collagen cross-linking parallels left ventricular dilatation in rat models of systolic chamber dysfunction.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Abdominal; Body Weight; Captopril; Collage | 2001 |
Differential alteration of cardiotonic effects of EMD 57033 and beta-adrenoceptor agonists in volume-overload rabbit ventricular myocytes.
Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Cardiotonic Agents; Disease Models, Animal; Dobutam | 2000 |
[Effects of isoprenaline on apoptosis related gene expression in rat myocardium cells].
Topics: Animals; Apoptosis; Cardiotonic Agents; Disease Models, Animal; Gene Expression; Isoproterenol; Male | 2000 |
Antiadrenergic effects of adenosine in pressure overload hypertrophy.
Topics: Adenosine; Adrenergic Antagonists; Adrenergic beta-Agonists; Animals; Blood Pressure; Body Weight; C | 2001 |
Impaired neurotransmitter release from lacrimal and salivary gland nerves of a murine model of Sjögren's syndrome.
Topics: Acetylcholine; Animals; Choline; Disease Models, Animal; Female; Injections, Intraperitoneal; Isopro | 2001 |
Impaired sarcoplasmic reticulum function leads to contractile dysfunction and cardiac hypertrophy.
Topics: Animals; Atrial Natriuretic Factor; Calcium; Calcium-Transporting ATPases; Cardiomegaly; Cardiotonic | 2001 |
Maintained contractile reserve in a transgenic mouse model of myocardial stunning.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Calcium-Transporting ATPases; Disease Models, Animal; Do | 2001 |
Effects of alpha - and beta -adrenergic stimulation on hepatosplanchnic perfusion and oxygen extraction in endotoxic shock.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Blood Flow Velocity; Cardiac Output; D | 2001 |
Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Caffeine; Calc | 2001 |
In vitro therapy with dobutamine, isoprenaline and sodium nitroprusside protects vascular smooth muscle metabolism from subarachnoid haemorrhage induced cerebral vasospasm.
Topics: Adrenergic beta-Agonists; Animals; Carotid Arteries; Disease Models, Animal; Dobutamine; Humans; In | 2001 |
Phenotypic deficits in mice expressing a myosin binding protein C lacking the titin and myosin binding domains.
Topics: Adrenergic beta-Agonists; Animals; Cardiomyopathy, Hypertrophic; Carrier Proteins; Connectin; Desmin | 2001 |
[Myocyte apoptosis in catecholamine-induced cardiomyopathy].
Topics: Animals; Apoptosis; Calcineurin; Cardiomyopathies; Disease Models, Animal; Isoproterenol; Male; Myoc | 2001 |
Salivary growth factors in health and disease.
Topics: Animals; Atrophy; Cell Division; Cells, Cultured; Disease Models, Animal; Epithelium; Fibroblast Gro | 2000 |
beta(1)-Receptors increase cAMP and induce abnormal Ca(i) cycling in the German shepherd sudden death model.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Calcium Signaling; Catecholamines; Cell Differentiation; | 2002 |
Effect of diabetes mellitus on hemodynamic and cardiometabolic correlates in experimental myocardial infarction.
Topics: Analysis of Variance; Animals; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Animal; | 2001 |
Heart function challenged with beta-receptor agonism or antagonism in a heart failure model.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Animals, Newborn; Blood Pressure; Ca | 2001 |
Beta-adrenergic stimulation of pig myocytes with decreased cytosolic free magnesium prolongs the action potential and enhances triggered activity.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Calcium Channels; Disease Models, Animal; Inci | 2002 |
Comparison of the effects of timolol and other adrenergic agents on intraocular pressure in the rabbit.
Topics: Adrenergic beta-Antagonists; Animals; Aqueous Humor; Chymotrypsin; Disease Models, Animal; Epinephri | 1977 |
Modification of mucus in animal models of disease.
Topics: Animals; Bronchi; Disease Models, Animal; Epithelium; Glycoproteins; Hydrogen-Ion Concentration; Hyp | 1977 |
Adenosine 3':5'-monophosphate and guanosine 3':5'-monophosphate: levels and cyclase activities in liver and adipose tissue from diabetic mice (db/db).
Topics: Adenylyl Cyclases; Adipose Tissue; Animals; Cell Membrane; Cyclic AMP; Cyclic GMP; Diabetes Mellitus | 1978 |
An in vitro model of canine immediate-type hypersensitivity reactions.
Topics: Animals; Antigens; Ascaris; Carbachol; Cromolyn Sodium; Disease Models, Animal; Dogs; Guanidines; Hi | 1976 |
Early demonstration of experimental aludrin-induced myocardial damage by the stain according to Lie et al. (HBFP).
Topics: Animals; Coronary Disease; Disease Models, Animal; Dogs; Isoproterenol; Oxygen Consumption; Rats; St | 1977 |
Pharmacologic profile of a new antiallergic compound PRD-92-Ea.
Topics: Animals; Asthma; Benzopyrans; Cromolyn Sodium; Disease Models, Animal; Haplorhini; Histamine Release | 1977 |
Conscious primate model for evaluating antiallergic drugs.
Topics: Albuterol; Animals; Ascaris; Cromolyn Sodium; Disease Models, Animal; Haplorhini; Histamine Release; | 1979 |
Adrenergaically mediated ventricular fibrillation in probucol-treated dogs: roles of alpha and beta adrenergic receptors.
Topics: Angiotensin II; Animals; Death, Sudden; Disease Models, Animal; Dogs; Dose-Response Relationship, Dr | 1979 |
The isoproterenol stress test in unanesthetized atherosclerotic rabbits.
Topics: Animals; Arteriosclerosis; Coronary Disease; Dipyridamole; Disease Models, Animal; Electrocardiograp | 1978 |
Ascaris-induced respiratory responses in the conscious rhesus monkey.
Topics: Aerosols; Animals; Antigens; Ascaris; Cromolyn Sodium; Disease Models, Animal; Female; Haplorhini; H | 1979 |
Experimental myocardial infarction with left ventricular failure in the isolated perfused rat heart. Effects of isoproterenol and pacing.
Topics: Animals; Blood Pressure; Cardiac Output; Cardiomegaly; Disease Models, Animal; Heart; Heart Failure; | 1975 |
Comparison of heart sarcolemmal enzyme activities in normal and cardiomyopathic (UM-X7.1) hamsters.
Topics: Adenosine Triphosphatases; Adenylyl Cyclases; Animals; Calcium; Cricetinae; Disease Models, Animal; | 1976 |
Role of hypertension in ischemic heart disease and cerebral vascular disease in the cynomolgus monkey with coarctation of the aorta.
Topics: Animals; Aortic Coarctation; Blood Pressure; Cardiomegaly; Cardiovascular Diseases; Cerebral Arterie | 1977 |
Protein fractions and antigens of the heart muscle in isoproterenol induced cardiac hypertrophy.
Topics: Animals; Antigens; Cardiomegaly; Disease Models, Animal; Heart Ventricles; Isoproterenol; Muscle Pro | 1976 |
The chronically reserpinized rat as a possible model for cystic fibrosis. I. Submaxillary gland morphology and ultrastructure.
Topics: Animals; Body Weight; Cell Nucleus; Cystic Fibrosis; Cytoplasm; Disease Models, Animal; Endoplasmic | 1975 |
Cyclic AMP metabolism in the cardiac tissue of the spontaneously hypertensive rat.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Crosses, Genetic; Cyclic AMP; Disea | 1976 |
[Qualitative and quantitative histoenzymatic study on isoproterenol induced myocardial necroses in rats (author's transl)].
Topics: Animals; Cardiomyopathies; Disease Models, Animal; Electron Transport Complex IV; Isoproterenol; Mal | 1976 |
Changes of adrenoceptor-mediated responses in the pithed rat during propylthiouracil-induced hypothyroidism.
Topics: Animals; Atropine; Blood Pressure; Bupranolol; Clonidine; Disease Models, Animal; Electric Stimulati | 1979 |
The effects of common bile duct ligation upon the rat liver beta-adrenergic receptor-adenylate cylase system.
Topics: Adenylyl Cyclases; Animals; Bile Ducts; Cell Membrane; Cholestasis; Dihydroalprenolol; Disease Model | 1979 |
Haemodynamics of ACTH-induced hypertension in sheep.
Topics: Acebutolol; Adrenocorticotropic Hormone; Animals; Blood Pressure; Cardiac Output; Disease Models, An | 1979 |
[Protective action of drugs against myocardial damage in rats].
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Disease Mode | 1975 |
[Animal model for the etiopathogenesis of sialadenitis].
Topics: Animals; Castration; Disease Models, Animal; Female; Isoproterenol; Parotid Gland; Rats; Salivary Gl | 1977 |
Inotropic agents and functional recovery from ischemic cardiac arrest.
Topics: Animals; Cardiopulmonary Bypass; Catecholamines; Disease Models, Animal; Dobutamine; Heart; Heart Ar | 1979 |
A temporal profile of changes in myocardial manganese after isoprenaline induced cardiac necrosis in albino rats.
Topics: Animals; Aspartate Aminotransferases; Disease Models, Animal; Electrocardiography; Isoproterenol; L- | 1979 |
Myocardial anaerobic metabolism during isoprenaline infusion in a cyanotic animal model: possible cause of myocardial dysfunction in cyanotic congential heart disease.
Topics: Anaerobiosis; Animals; Cardiac Pacing, Artificial; Cyanosis; Disease Models, Animal; Dogs; Heart; He | 1979 |
Creating permanent complete heart block by indirect cauterization without atriotomy.
Topics: Animals; Atrioventricular Node; Cautery; Disease Models, Animal; Dogs; Heart Atria; Heart Block; Hea | 1977 |
[Accumulation of tetracycline, Sn-tetracycline, and 99mTc-Sn-tetracykline in isoprenaline-damaged rat myocardium (author's transl)].
Topics: Animals; Cardiomyopathies; Disease Models, Animal; Isoproterenol; Myocardium; Rats; Technetium; Tetr | 1978 |
Subcutaneous isoproterenol: a convenient rat model for early detection of myocardial necrosis.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Radiation; Isoproterenol; Myocardial In | 1978 |
[Modification of isoprenaline-induced myocardial necrosis in the rat by means of pre-treatment with cerutil and piracetam].
Topics: Animals; Coronary Disease; Disease Models, Animal; Glycolates; Heart; Isoproterenol; Male; Meclofeno | 1976 |
[The effect of carbocromen on the ST segment of the epicardial electrocardiogram in a model of intermitting myocardial ischemia (author's transl)].
Topics: Animals; Blood Pressure; Chromonar; Coronary Circulation; Coronary Disease; Coumarins; Disease Model | 1976 |
Anaphylactic contraction of pulmonary blood vessels of chicken.
Topics: Acetylcholine; Anaphylaxis; Animals; Bradykinin; Chickens; Coronary Vessels; Disease Models, Animal; | 1977 |
Effect of drugs on conduction delay and incidence of ventricular arrhythmias induced by acute coronary occlusion in dogs.
Topics: Animals; Aprindine; Arrhythmias, Cardiac; Coronary Disease; Disease Models, Animal; Dogs; Heart Cond | 1977 |
The chronically reserpinized rat as a possible model for cystic fibrosis. VI. Synergistic effects of isoproterenol on Ca++ and protein in the submaxillary gland.
Topics: Animals; Calcium; Cystic Fibrosis; Disease Models, Animal; Drug Synergism; Isoproterenol; Male; Prot | 1977 |
Effect of regional myocardial ischaemia on left ventricular isovolumic contraction.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Disease Models, Animal; Dogs; Femal | 1977 |
Pharmacological effect on shock conditions. V communication. Effect on experimental anaphylactic shock using neurotropic drugs and substances suppressing cellular reactivity.
Topics: Aminophylline; Anaphylaxis; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 1977 |
Animal model of human disease: chronic bronchitis.
Topics: Animals; Bronchi; Bronchitis; Disease Models, Animal; Isoproterenol; Swine; Swine Diseases | 1976 |
Localization by autoradiography of tritiated isoproterenol in "infarct-like" lesions of rat myocardium.
Topics: Animals; Autoradiography; Disease Models, Animal; Isoproterenol; Myocardial Infarction; Myocardium; | 1976 |
[Quantitative evaluation of histochemical examinations of the protective effect of KMg-aspartate upon necroses of the myocardium experimentally induced by isoproterenol (author's transl)].
Topics: Animals; Aspartic Acid; Cardiomyopathies; Disease Models, Animal; Dogs; Isoproterenol; Magnesium; Ne | 1976 |
Coronary steal: its role in detrimental effect of isoproterenol after acute coronary occlusion in dogs.
Topics: Adenosine; Animals; Blood Pressure; Collateral Circulation; Coronary Circulation; Disease Models, An | 1976 |
[Modification of the isoprenaline-induced myocardial necrosis using trapidil].
Topics: Animals; Cardiomyopathies; Disease Models, Animal; Isoproterenol; Male; Myocardial Infarction; Necro | 1976 |
[Influence of trimepranol and practolol on the heart damaged by isoprenaline].
Topics: Animals; Disease Models, Animal; Heart Diseases; Isoproterenol; Phenyl Ethers; Practolol; Propanolam | 1976 |
Prenylamine inhibition of isoproterenol induced myocardial lesions. Histochemical and ultrastructural findings.
Topics: Animals; Calcium; Disease Models, Animal; Isoproterenol; Myocardial Infarction; Myocardium; Oxygen C | 1976 |
Brain amines and models of experimental hypertension.
Topics: Animals; Blood Pressure; Brain Stem; Cerebral Ventricles; Corticosterone; Disease Models, Animal; Do | 1975 |
Evaluation of precordial electrocardiographic mapping as a means of assessing changes in myocardial ischemic injury.
Topics: Acute Disease; Animals; Creatine Kinase; Disease Models, Animal; Dogs; Electrocardiography; Evaluati | 1975 |
The chronically reserpinized rat as a possible model for cystic fibrosis. II. Comparison and cilioinhibitory effects of submaxillary saliva.
Topics: Animals; Biological Assay; Bivalvia; Calcium; Carbohydrates; Cilia; Cystic Fibrosis; Disease Models, | 1975 |
Isoprenaline-induced cardiac necroses in normotensive and in spontaneously hypertensive rats.
Topics: Animals; Disease Models, Animal; Electrocardiography; Female; Heart Diseases; Hypertension; Isoprote | 1975 |
Letter: Experimental asthma in conscious allergic dogs.
Topics: Airway Resistance; Animals; Antigens; Asthma; Atropine; Disease Models, Animal; Dogs; Histamine; Iso | 1975 |
Pulmonary capillary permeability in man and a canine model of chemical pulmonary edema.
Topics: Adult; Alloxan; Animals; Blood Flow Velocity; Blood Pressure; Blood Volume; Capillaries; Capillary P | 1975 |
Metabolic and histopathologic changes in arteriosclerotic versus nonarteriosclerotic rats following isoproterenol-induced myocardial infarction with superimposed diabetes.
Topics: Acute Disease; Animals; Arteriosclerosis; Diabetes Mellitus, Experimental; Disease Models, Animal; F | 1975 |
Method for the production of severe ventricular dysrhythmias in small laboratory animals.
Topics: Animals; Animals, Laboratory; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Desoxycorticosterone; Di | 1975 |
Electrolytes in myocardial infarction.
Topics: Animals; Calcium; Cell Membrane Permeability; Disease Models, Animal; Humans; Isoproterenol; Magnesi | 1975 |
Regulation of cardiac adenylate cyclase activity in rodent models of obesity.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Binding, Competitive; Disease Models, Animal; | 1992 |
Effect of hyperlipidemia on cardiovascular responses to adrenergic stimulation in piglets.
Topics: Analysis of Variance; Animals; Blood Pressure; Cholesterol; Disease Models, Animal; Heart Rate; Hemo | 1992 |
Alterations in G-protein expression, Gi function and stimulatory receptor-mediated regulation of adipocyte adenylyl cyclase in a model of insulin-resistant diabetes with obesity.
Topics: Adenylyl Cyclases; Adipose Tissue; Animals; Cell Membrane; Cells, Cultured; Colforsin; Diabetes Mell | 1992 |
Vasodepressor reaction induced by inferior vena caval occlusion and isoproterenol.
Topics: Animals; Atropine; Disease Models, Animal; Drug Administration Routes; Heart Rate; Hypotension; Infu | 1992 |
Localization of the reflex pathway responsible for the vasodepressor reaction induced by inferior vena caval occlusion and isoproterenol.
Topics: Animals; Atropine Derivatives; Bradycardia; Disease Models, Animal; Heart; Heart Ventricles; Hypoten | 1992 |
The effects of sympathetic denervation on spontaneous ventricular defibrillation in the rat.
Topics: Animals; Blood Pressure; Disease Models, Animal; Heart; Heart Ventricles; Isoproterenol; Male; Neuro | 1992 |
Functional changes in the right and left ventricle during development of cardiac hypertrophy and after its regression.
Topics: Animals; Cardiomegaly; Collagen; Disease Models, Animal; Heart Ventricles; Isoproterenol; Male; Rats | 1992 |
Interaction of catecholamine and acetazolamide in the action on the endolymphatic sac direct current potential.
Topics: Acetazolamide; Action Potentials; Animals; Disease Models, Animal; Drug Synergism; Endolymphatic Sac | 1992 |
Nanomolar L-dopa facilitates release of dopamine via presynaptic beta-adrenoceptors: comparative studies on the actions in striatal slices from control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated C57 black mice, an animal model for Par
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Disease Models, Animal; Dopa | 1991 |
Thermogenic responses to selective and nonselective beta-adrenerg agonists in hypothyroidism of Sprague-Dawley rats.
Topics: Adipose Tissue; Adrenergic beta-Agonists; Animals; Body Weight; Disease Models, Animal; Guanosine Di | 1991 |
Effect of bladder outflow obstruction on the innervation of the rabbit urinary bladder.
Topics: Animals; Denervation; Disease Models, Animal; Isoproterenol; Male; Muscle, Smooth; Parasympathetic N | 1990 |
Eosinophil accumulation in rats injected with Sephadex particles.
Topics: Animals; Dapsone; Dexamethasone; Dextrans; Disease Models, Animal; Eosinophilia; Eosinophils; Inject | 1990 |
Left ventricular function in dogs 1 year after coarctectomy.
Topics: Animals; Aortic Coarctation; Dextrans; Disease Models, Animal; Dogs; Exercise Test; Heart Ventricles | 1991 |
Converting enzyme inhibition after experimental myocardial infarction in rats: comparative study between spirapril and zofenopril.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Disease Models, Animal; Enalapril; Hea | 1991 |
[Dynamic biochemical, metrometric and histomorphological studies in isoproterenol-induced myocardial hypertrophy and its regression in rats].
Topics: Animals; Body Weight; Cardiomegaly; Connective Tissue; Disease Models, Animal; Heart; Isoproterenol; | 1991 |
Oxygen metabolism of the hypertrophic right ventricle in open chest dogs.
Topics: Animals; Cardiomegaly; Coronary Vessels; Disease Models, Animal; Dogs; Female; Isoproterenol; Male; | 1991 |
Metoprolol and ventricular repolarisation and refractoriness: lack of chronic adaptational class III effects in rabbit.
Topics: Animals; Disease Models, Animal; Electrophysiology; Epinephrine; Heart; Isoproterenol; Male; Metopro | 1991 |
Changes in performance of the surviving myocardium after left ventricular infarction in rats.
Topics: Animals; Blood Pressure; Calcium; Cardiomegaly; Disease Models, Animal; Female; Heart; Isoproterenol | 1990 |
Reactive and reparative fibrillar collagen remodelling in the hypertrophied rat left ventricle: two experimental models of myocardial fibrosis.
Topics: Animals; Cardiomegaly; Collagen; Disease Models, Animal; Fibrosis; Heart; Ischemia; Isoproterenol; K | 1990 |
Ultrastructural and electrophysiological alterations during the development of catecholamine-induced cardiac hypertrophy and failure.
Topics: Action Potentials; Animals; Body Weight; Cardiomegaly; Disease Models, Animal; Heart Failure; Isopro | 1990 |
Differential regulation of right and left ventricular beta-adrenergic receptors in newborn lambs with experimental cyanotic heart disease.
Topics: Adenylyl Cyclases; Animals; Animals, Newborn; Cyanosis; Disease Models, Animal; Epinephrine; Heart; | 1990 |
Serum angiotensin converting enzyme activity and plasma renin activity in experimental models of rats.
Topics: Animals; Disease Models, Animal; Hypertension, Renovascular; Isoproterenol; Kidney Diseases; Male; N | 1990 |
Desensitization of myocardial beta-adrenergic receptors in cirrhotic rats.
Topics: Animals; Disease Models, Animal; Down-Regulation; Heart; Heart Rate; Hypertension, Portal; Isoproter | 1990 |
Raised vascular calcium in an animal model: effects on aortic function.
Topics: Animals; Aorta; Calcinosis; Calcium; Cardiomyopathies; Disease Models, Animal; Ergocalciferols; Fema | 1990 |
Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Disease Models, Animal; Hernia, Diaphragmatic; Hernias | 1990 |
Cardiovascular adrenoreceptor number and function in experimental hypertension in the baboon.
Topics: Animals; Disease Models, Animal; Hemodynamics; Hypertension; Isoproterenol; Muscle, Smooth, Vascular | 1985 |
Effect of verapamil on the development of chronic experimental Chagas' disease.
Topics: Adenylyl Cyclases; Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Models, | 1989 |
Isoproterenol-induced alterations in myocardial blood flow, systolic and diastolic function in conscious dogs with heart failure.
Topics: Animals; Cardiomegaly; Coronary Circulation; Diastole; Disease Models, Animal; Dogs; Female; Heart F | 1989 |
Elevated blood pressure and heart rate in rats exposed to a coal-derived complex organic mixture.
Topics: Administration, Inhalation; Animals; Blood Pressure; Coal Tar; Diphosphates; Disease Models, Animal; | 1989 |
Isoproterenol sensitivity of isolated cardiac myocytes from rats with monocrotaline-induced right-sided hypertrophy and heart failure.
Topics: Animals; Calcium-Transporting ATPases; Cardiomegaly; Catecholamines; Cells, Cultured; Disease Models | 1989 |
Hemodynamics and blood flow distribution in experimental shock. The effect of noradrenaline and isoproterenol.
Topics: Animals; Cardiac Output; Disease Models, Animal; Dogs; Female; Hemodynamics; Isoproterenol; Male; No | 1989 |
Cyclic nucleotide function in trachealis muscle of dogs with and without airway hyperresponsiveness.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Asthma; Cyclic AM | 1987 |
Effects of chronic ethanol ingestion on mouse brain beta-adrenergic receptors (BAR) and adenylate cyclase.
Topics: Adenylyl Cyclases; Alcoholism; Animals; Cerebellum; Cerebral Cortex; Disease Models, Animal; Guanine | 1988 |
Adrenergic sensitivity of cultured murine trisomy 16 cells.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Alprostadil; Animals; Cell Line; Cells, Cultured; Disea | 1985 |
X-ray microanalysis of exocrine glands in animal models for cystic fibrosis.
Topics: Adrenergic beta-Agonists; Animals; Cystic Fibrosis; Cytoplasmic Granules; Disease Models, Animal; El | 1985 |
[Effects of prazosin, SGB-1534, dobutamine and isoproterenol on congestive heart failure in dogs].
Topics: Adrenergic alpha-Antagonists; Animals; Disease Models, Animal; Dobutamine; Dogs; Heart Failure; Hemo | 1988 |
The protective mechanism of thyroidectomy in a rat model of chronic renal failure.
Topics: Animals; Disease Models, Animal; Glomerular Filtration Rate; Hemodynamics; Isoproterenol; Kidney Fai | 1989 |
Impaired inotropic responses to alpha-adrenergic stimulation in experimental left ventricular hypertrophy.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Heart Ventricles; Hypertension, Renal; Isoproterenol; | 1985 |
Decreased membrane fluidity and beta-adrenergic responsiveness in atherosclerotic quail.
Topics: Animals; Arteriosclerosis; Cholesterol; Cholesterol, Dietary; Coturnix; Cyclic AMP; Disease Models, | 1985 |
Loss of high affinity cardiac beta adrenergic receptors in dogs with heart failure.
Topics: Adenylyl Cyclases; Animals; Disease Models, Animal; Dogs; Female; Guanylyl Imidodiphosphate; Heart F | 1985 |
Prevention of canine anaphylaxis with isoproterenol.
Topics: Airway Resistance; Anaphylaxis; Animals; Blood Pressure; Cardiac Output; Cyclic AMP; Disease Models, | 1986 |
[Absence, in the hypertrophied rat heart caused by aortocaval fistula, of several metabolic and electrophysiological changes seen in other models of hypertrophy].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Aorta, Abdominal; Aortic Valve Stenosis; Cardiom | 1985 |
Changes in glycoconjugates in rat submandibular gland after chronic treatment with reserpine and isoproterenol.
Topics: Animals; Cystic Fibrosis; Cytoplasmic Granules; Disease Models, Animal; Glycoconjugates; Isoproteren | 1988 |
Effects of chronic furosemide treatment on rat exocrine glands.
Topics: Animals; Biological Transport; Cations; Chlorides; Cystic Fibrosis; Disease Models, Animal; Exocrine | 1988 |
Dietary potassium, blood pressure and peripheral adrenergic responsiveness in the deoxycorticosterone acetate-salt rat.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Diet; Disease Models, Animal; Hypertension; Isoproter | 1988 |
An experimental model for myocardial ischaemia in rabbits.
Topics: Animals; Coronary Angiography; Coronary Disease; Disease Models, Animal; Electrocardiography; Female | 1987 |
Comparison of drug responses in vivo and in vitro in airways of dogs with and without airway hyperresponsiveness.
Topics: Aerosols; Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Disease Models, Animal; D | 1986 |
Comparative circulatory effects of isoproterenol, dopamine, and dobutamine in conscious lambs with and without aortopulmonary left-to-right shunts.
Topics: Animals; Blood Circulation; Disease Models, Animal; Dobutamine; Dopamine; Drug Evaluation, Preclinic | 1987 |
Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death.
Topics: Animals; Anti-Arrhythmia Agents; Body Weight; Bretylium Tosylate; Death, Sudden; Disease Models, Ani | 1986 |
Ventricular fibrillation threshold in canine hearts with quinidine induced prolonged QT interval: effects of atrial pacing, isoproterenol, and lignocaine.
Topics: Animals; Cardiac Pacing, Artificial; Disease Models, Animal; Dogs; Female; Heart; Isoproterenol; Lid | 1986 |
Left ventricular function in myocardial ischaemia.
Topics: Angiography; Animals; Cineangiography; Coronary Disease; Coronary Vasospasm; Disease Models, Animal; | 1985 |
Angiotensin-induced hypertension in conscious dogs: biochemical parameters and baroreceptor reflex.
Topics: Aldosterone; Angiotensin II; Animals; Body Weight; Consciousness; Disease Models, Animal; Dogs; Fema | 1985 |
Effects of noradrenaline and isoproterenol on cardiopulmonary function in a canine model of acute pulmonary hypertension.
Topics: Animals; Blood Pressure; Cardiac Output; Disease Models, Animal; Dogs; Heart Rate; Hemodynamics; Hyp | 1985 |
Inhomogeneity of ventricular refractory period in canine heart with quinidine-induced long QT interval: a comparative study on effects of heart rate, isoprenaline, and lignocaine.
Topics: Animals; Disease Models, Animal; Dogs; Electric Stimulation; Female; Heart; Heart Rate; Isoprotereno | 1985 |
A new model of ventricular fibrillation induced by isoprenaline and catechol-O-methyl transferase inhibitor at a high perfusion temperature in isolated rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Catechol O-Methyltransferase Inhibitors; Disease Models, Animal; El | 1985 |
[Influencing of the circulation rate and oxygen metabolism in the ischemic myocardium. Comparison with the effect on the normal myocardium].
Topics: Adrenergic beta-Agonists; Animals; Blood Flow Velocity; Cardiac Catheterization; Chemotherapy, Cance | 1974 |
Experimental cardiomyopathies in poikilotherms.
Topics: Alligators and Crocodiles; Amphibians; Animals; Anura; Arteries; Bufo bufo; Cardiomyopathies; Corona | 1973 |
[Influencing of the isoprenaline necrosis of the myocardium by ATP-Spofa administration].
Topics: Adenosine Triphosphate; Animals; Cardiomegaly; Disease Models, Animal; Female; Heart; Isoproterenol; | 1971 |
Isoproterenol-induced cardiomegaly: assessment of myocardial protein content, actomyosin ATPase and heart rate.
Topics: Actomyosin; Adenosine Triphosphatases; Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal | 1972 |
Comparative morphological study of some experimental models of myocardial hypertrophy.
Topics: Animals; Aortic Valve Stenosis; Cardiomegaly; Disease Models, Animal; Isoproterenol; Male; Mice; Myo | 1971 |
Role of endocrine factors in the pathogenesis of cardiac hypertrophy.
Topics: Acromegaly; Animals; Body Weight; Cardiomegaly; Catecholamines; Disease Models, Animal; Growth Hormo | 1974 |
Instrumented primates as cardiovascular models.
Topics: Acetylcholine; Animals; Blood Circulation; Blood Pressure Determination; Capillary Resistance; Cardi | 1974 |
Experimental left ventricular akinesis: results of excision.
Topics: Acetylcholine; Angiocardiography; Angiotensin II; Animals; Blood Pressure; Cardiac Output; Cineangio | 1970 |
Pharmacological studies on active bronchial anaphylaxis in the rat.
Topics: Aluminum Hydroxide; Anaphylaxis; Animals; Atropine; Bordetella pertussis; Bronchial Spasm; Cromolyn | 1974 |
Nutritional circulation in the heart. 3. Effect of isoproterenol and beta adrenergic blockade on myocardial hemodynamics and rubicium-86 extraction in the isolated supported heart preparation.
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Animals; Blood Circulation; Blood Flow V | 1970 |
Protective effect of beta adrenoceptor blockade in experimental coronary occlusion in conscious dogs.
Topics: Acetanilides; Adrenergic beta-Antagonists; Amino Alcohols; Animals; Coronary Disease; Disease Models | 1972 |
Rat salivary glands after long-term isoproterenol administration.
Topics: Animals; Cell Membrane; Cell Nucleolus; Cyclophosphamide; Cytoplasm; Disease Models, Animal; Endopla | 1974 |
The pathophysiology of tachycardia-dependent paroxysmal atrioventricular block after acute myocardial ischemia. Experimental and clinical observations.
Topics: Adams-Stokes Syndrome; Aged; Animals; Bundle of His; Coronary Disease; Coronary Vessels; Disease Mod | 1974 |
[Dynamic follow-up study of the influence of K and Mg asparaginate (Cardilan Spofa) on the development of isoprenaline-induced myocardial necroses in the electron microscopy picture].
Topics: Animals; Asparagine; Cardiomyopathies; Disease Models, Animal; Heart; Isoproterenol; Magnesium; Micr | 1974 |
Immunofluorescent studies in isoproterenol-induced myocardial necrosis in rats.
Topics: Animals; Antibodies; Disease Models, Animal; Fluorescent Antibody Technique; Injections, Subcutaneou | 1974 |
Studies of immunoreactive insulin secretion in NZO mice in vivo.
Topics: Aminophylline; Animals; Antigens; Arginine; Diabetes Mellitus; Disease Models, Animal; Fasting; Gluc | 1974 |
[Pressure and contractility of the left ventricle under various conditions in the Syrian golden hamster with hereditary cardiomyopathy].
Topics: Animals; Blood Pressure; Cardiomyopathies; Cricetinae; Dextrans; Disease Models, Animal; Heart Ventr | 1972 |
Subendocardial anaerobic metabolism in experimental aortic stenosis.
Topics: Adenosine Triphosphate; Anaerobiosis; Animals; Aorta, Thoracic; Aortic Valve Stenosis; Blood Pressur | 1973 |
Effects of isoproterenol, l-norepinephrine, and glucagon on myocardial gas tensions in animals with coronary artery stenosis.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Disease Models, Animal; Dogs; Gluca | 1973 |
Effects of isoproterenol during hemorrhagic shock in the rat.
Topics: Animals; Behavior, Animal; Bicarbonates; Blood Pressure; Body Temperature; Disease Models, Animal; D | 1973 |
[Various factors influencing the development of experimental myocardial necrosis].
Topics: Animals; Cardiomyopathies; Disease Models, Animal; Isoproterenol; Lipid Metabolism; Necrosis; Rats | 1973 |
Ultrastructural changes in isoproterenol-induced atrial necrosis.
Topics: Animals; Cardiomyopathies; Desoxycorticosterone; Disease Models, Animal; Isoproterenol; Male; Micros | 1973 |
Modification of experimental myocardial infarct size by cardiac drugs.
Topics: Animals; Blood Pressure; Cardiac Catheterization; Cardiac Volume; Coronary Circulation; Coronary Ves | 1974 |
Isoproterenol-induced myocardial infarction in the gerbil (Meriones unguiculatus).
Topics: Adrenal Glands; Animals; Blood Glucose; Blood Urea Nitrogen; Cholesterol; Creatine Kinase; Disease M | 1974 |
Ongoing activity in peripheral nerves: the physiology and pharmacology of impulses originating from a neuroma.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Evoked Potentials; Isoproterenol; Nerve Degen | 1974 |
Relationships between increased automaticity and depressed conduction in the main intraventricular conducting fascicles of the human and canine heart.
Topics: Aged; Animals; Bundle-Branch Block; Carotid Sinus; Disease Models, Animal; Dogs; Electrocardiography | 1974 |
Model of human coronary artery disease for acute experimentation.
Topics: Animals; Arteries; Blood Flow Velocity; Blood Pressure; Cardiac Output; Coronary Circulation; Corona | 1974 |
Reactive pulmonary arterial hypertension after pulmonary venous constriction in the calf.
Topics: Acetylcholine; Animals; Blood Pressure; Carbon Dioxide; Cardiac Catheterization; Cardiac Output; Cat | 1972 |
[Effect of vasoactive drugs and conditioning on histologic changes of liver tissues in rats subjected to tourniquet trauma].
Topics: Animals; Conditioning, Psychological; Disease Models, Animal; Epinephrine; Isoproterenol; Liver; Rat | 1972 |
The development of resistance to the ischemic cardiopathic effect of isoproterenol.
Topics: Animals; Blood Pressure; Coronary Disease; Disease Models, Animal; Dogs; Drug Resistance; Electrocar | 1972 |
Effects of intraaortic balloon counterpulsation on the severity of myocardial ischemic injury following acute coronary occlusion. Counterpulsation and myocardial injury.
Topics: Acute Disease; Animals; Assisted Circulation; Coronary Circulation; Coronary Disease; Coronary Vesse | 1972 |
[Effect of Cardilan infusion on the arrhythmic and lethal dose of g-strophantin in a model of experimental isoprenaline necrosis].
Topics: Animals; Arrhythmias, Cardiac; Asparagine; Disease Models, Animal; Heart; Heart Rate; Injections, In | 1972 |
[Experimental study on drugs for the treatment of myocardial infarction].
Topics: Angiography; Animals; Benzyl Compounds; Body Weight; Carboxylic Acids; Dipyridamole; Disease Models, | 1972 |
An experimental model of micronecrosis in the myocardium in rats.
Topics: Animals; Disease Models, Animal; Heart Diseases; Injections, Intraperitoneal; Isoproterenol; Myocard | 1971 |
Effect of pretreatment and treatment with isoproterenol on experimental massive pulmonary embolism in the rat.
Topics: Animals; Arrhythmia, Sinus; Blood Pressure; Bradycardia; Disease Models, Animal; Isoproterenol; Pulm | 1971 |
[Effect of ATP-Spofa on the level of total lactate dehydrogenase in the blood of rats following administration of isoprenaline (IP)].
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Female; Heart; Heart Diseases; Isoprotereno | 1971 |
The effects of dimethylsulfoxide (DMSO) on the healing of experimental myocardial necrosis.
Topics: Animals; Dimethyl Sulfoxide; Disease Models, Animal; Isoproterenol; Male; Myocardial Infarction; Myo | 1970 |
Isoproterenol-induced cardiac lesions in frog observed in vivo.
Topics: Animals; Anura; Blood Pressure; Disease Models, Animal; Female; Heart; Heart Aneurysm; Heart Disease | 1970 |
[Influence of adenosine triphorphoric acid on fat infiltration of the rat liver induced by isoproterenol].
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Fatty Liver; Infusions, Parenteral; Injecti | 1970 |
Therapeutic studies in experimental amniotic fluid embolism in rabbits.
Topics: Anaphylaxis; Animals; Atropine; Bronchial Spasm; Disease Models, Animal; Electrocardiography; Emboli | 1970 |
[Role of the lysosome system in the preventive effect of adaptation to high-altitude hypoxia in heart diseases].
Topics: Acid Phosphatase; Adaptation, Physiological; Animals; Aortic Coarctation; Deoxyribonucleases; Diseas | 1970 |
Experimental study of the effects of infusions of isoprenaline sulphate and low molecular weight dextran in haemorrhagic shock in the dog.
Topics: Animals; Dextrans; Disease Models, Animal; Dogs; Injections, Intravenous; Isoproterenol; Shock, Hemo | 1969 |