isoproterenol has been researched along with Diabetes Mellitus, Type 2 in 41 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Excerpt | Relevance | Reference |
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" This work investigated the protective effect of pioglitazone on myocardial infarction (MI) in non-diabetic and diabetic rats, focusing on its role on advanced glycated endproducts (AGEs) and cardiac apoptotic machinery." | 7.83 | Cardioprotective effect of pioglitazone in diabetic and non-diabetic rats subjected to acute myocardial infarction involves suppression of AGE-RAGE axis and inhibition of apoptosis. ( Farag, NE; Khodeer, DM; Moustafa, YM; Zaitone, SA, 2016) |
" This work investigated the protective effect of pioglitazone on myocardial infarction (MI) in non-diabetic and diabetic rats, focusing on its role on advanced glycated endproducts (AGEs) and cardiac apoptotic machinery." | 3.83 | Cardioprotective effect of pioglitazone in diabetic and non-diabetic rats subjected to acute myocardial infarction involves suppression of AGE-RAGE axis and inhibition of apoptosis. ( Farag, NE; Khodeer, DM; Moustafa, YM; Zaitone, SA, 2016) |
"Curcumin, an active component derived from dietary spice turmeric (Curcuma longa), has been demonstrated antihyperglycemic, antiinflammatory and hypocholesterolemic activities in obesity and diabetes." | 3.78 | Curcumin attenuates lipolysis stimulated by tumor necrosis factor-α or isoproterenol in 3T3-L1 adipocytes. ( Kong, PR; Li, Y; Li, YX; Wu, JF; Xie, XY, 2012) |
"In the search for potent and selective human beta3-adrenergic receptor (AR) agonists as potential drugs for the treatment of obesity and noninsulin-dependent (type II) diabetes, we prepared a novel series of phenoxypropanolamine derivatives containing the thiourea moiety and evaluated their biological activities at human beta3-, beta2-, and beta1-ARs." | 3.75 | Discovery of novel thiourea derivatives as potent and selective beta3-adrenergic receptor agonists. ( Hayakawa, M; Kawazoe, S; Maruyama, T; Matsui, T; Ohta, M; Onda, K; Seki, N; Suzuki, T; Takasu, T, 2009) |
"Obesity is an important risk factor for diabetes mellitus (DM) which is a major global health problem." | 1.72 | Effects of Isoprenaline on ventricular myocyte shortening and Ca ( Howarth, FC; Qureshi, MA; Sultan, A, 2022) |
"Type 2 diabetes mellitus is a complex metabolic disease, and cardiovascular disease is a leading complication of diabetes." | 1.43 | Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes. ( Antunes, M; Burgeiro, A; Carvalho, E; Carvalho, RA; Cherian, S; Espinoza, D; Fuhrmann, A; Jarak, I; Loureiro, M; Patrício, M, 2016) |
"One of the common complications of type 2 diabetes mellitus (DM2) are cardiovascular diseases and dysfunctions of the reproductive system, indicating the urgency of developing new approaches to their correction." | 1.40 | [The influence of two-month treatment with bromocryptine on activity of the adenylyl cyclase signaling system in the myocardium and testes of rats with type 2 diabetes mellitus]. ( Bondareva, VM; Derkach, KV; Moyseyuk, IV; Shpakov, AO, 2014) |
"Obesity is a common and rapidly growing health problem today." | 1.35 | Human mesenteric adipose tissue plays unique role versus subcutaneous and omental fat in obesity related diabetes. ( Abrams, GA; Aprahamian, CJ; Chen, M; Clements, RH; Harmon, CM; Yang, YK, 2008) |
"Approximately 40% of patients with type 2 diabetes present with concurrent hypertension at the time of diabetes diagnosis." | 1.35 | Decreased NO signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertension. ( Behnke, BJ; Delp, MD; Donato, AJ; Laughlin, MH; Lesniewski, LA; Ray, CA; Woodman, CR, 2008) |
"6." | 1.29 | The effects of glyburide and insulin on the cardiac performance in rats with non-insulin-dependent diabetes mellitus. ( Altan, VM; Ozçelkay, AT; Oztürk, Y; Ozüari, A; Yildizoğlu-Ari, N, 1993) |
"Risk factors for NIDDM were estimated by proportional-hazards analysis and risk ratios (RR) with 95% confidence intervals (95% CI) calculated at the 90th and 10th percentile of the predictor variables." | 1.29 | A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM. ( Bogardus, C; Foley, JE; Howard, BV; Paolisso, G; Ravussin, E; Tataranni, PA, 1995) |
"Treatment with isoproterenol plus adenosine deaminase rapidly inhibited insulin-stimulated glucose transport by 40%, and at the same time GLUT4 disappeared from the caveolae-rich fraction and from plasma membranes as a whole." | 1.29 | Insulin-stimulated glucose uptake involves the transition of glucose transporters to a caveolae-rich fraction within the plasma membrane: implications for type II diabetes. ( Gustavsson, J; Parpal, S; Strålfors, P, 1996) |
" In order to evaluate the importance of the Iso dose, dose-response studies were performed in 9 diabetics (fasting plasma glucose greater than 150 mg/dl) and 10 age-matched controls." | 1.26 | Mechanisms of impaired acute insulin release in adult onset diabetes: studies with isoproterenol and secretin. ( Halter, JB; Porte, D, 1978) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 5 (12.20) | 18.7374 |
1990's | 16 (39.02) | 18.2507 |
2000's | 8 (19.51) | 29.6817 |
2010's | 8 (19.51) | 24.3611 |
2020's | 4 (9.76) | 2.80 |
Authors | Studies |
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Bloom, JD | 1 |
Dutia, MD | 1 |
Johnson, BD | 1 |
Wissner, A | 1 |
Burns, MG | 1 |
Largis, EE | 1 |
Dolan, JA | 1 |
Claus, TH | 1 |
Maruyama, T | 1 |
Seki, N | 1 |
Onda, K | 1 |
Suzuki, T | 1 |
Kawazoe, S | 1 |
Hayakawa, M | 1 |
Matsui, T | 1 |
Takasu, T | 1 |
Ohta, M | 1 |
Nureki, I | 1 |
Kobayashi, K | 1 |
Tanaka, T | 1 |
Demura, K | 1 |
Inoue, A | 1 |
Shihoya, W | 1 |
Nureki, O | 1 |
Sultan, A | 1 |
Qureshi, MA | 1 |
Howarth, FC | 1 |
Bajic, Z | 1 |
Sobot, T | 1 |
Uletilovic, S | 1 |
Mandic-Kovacevic, N | 1 |
Cvjetkovic, T | 1 |
Malicevic, U | 1 |
Djukanovic, D | 1 |
Duran, M | 1 |
Vesic, N | 1 |
Avram, S | 1 |
Jovicic, S | 1 |
Katana, M | 1 |
Matavulj, A | 1 |
Ponorac, N | 1 |
Djuric, DM | 1 |
Stojiljkovic, MP | 1 |
Skrbić, R | 1 |
Trinh, MD | 1 |
Plihalova, A | 1 |
Gojda, J | 1 |
Westlake, K | 1 |
Spicka, J | 1 |
Lattova, Z | 1 |
Pretl, M | 1 |
Polak, J | 1 |
Cook, RF | 2 |
Bussey, CT | 2 |
Mellor, KM | 1 |
Cragg, PA | 2 |
Lamberts, RR | 2 |
Fomison-Nurse, IC | 1 |
Hughes, G | 1 |
Bahn, A | 1 |
Derkach, KV | 1 |
Bondareva, VM | 1 |
Moyseyuk, IV | 1 |
Shpakov, AO | 1 |
Burgeiro, A | 1 |
Fuhrmann, A | 1 |
Cherian, S | 1 |
Espinoza, D | 1 |
Jarak, I | 1 |
Carvalho, RA | 1 |
Loureiro, M | 1 |
Patrício, M | 1 |
Antunes, M | 1 |
Carvalho, E | 1 |
Khodeer, DM | 1 |
Zaitone, SA | 1 |
Farag, NE | 1 |
Moustafa, YM | 1 |
Yang, YK | 1 |
Chen, M | 1 |
Clements, RH | 1 |
Abrams, GA | 1 |
Aprahamian, CJ | 1 |
Harmon, CM | 1 |
Lessard, SJ | 1 |
Rivas, DA | 1 |
Chen, ZP | 1 |
van Denderen, BJ | 1 |
Watt, MJ | 1 |
Koch, LG | 1 |
Britton, SL | 1 |
Kemp, BE | 1 |
Hawley, JA | 1 |
Boardman, NT | 1 |
Larsen, TS | 2 |
Severson, DL | 2 |
Essop, MF | 1 |
Aasum, E | 1 |
Tocchetti, CG | 1 |
Caceres, V | 1 |
Stanley, BA | 1 |
Xie, C | 1 |
Shi, S | 1 |
Watson, WH | 1 |
O'Rourke, B | 1 |
Spadari-Bratfisch, RC | 1 |
Cortassa, S | 1 |
Akar, FG | 1 |
Paolocci, N | 1 |
Aon, MA | 1 |
Xie, XY | 1 |
Kong, PR | 1 |
Wu, JF | 1 |
Li, Y | 1 |
Li, YX | 1 |
Lam, TY | 1 |
Seto, SW | 1 |
Lau, YM | 1 |
Au, LS | 1 |
Kwan, YW | 1 |
Ngai, SM | 1 |
Tsui, KW | 1 |
Lesniewski, LA | 1 |
Donato, AJ | 1 |
Behnke, BJ | 1 |
Woodman, CR | 1 |
Laughlin, MH | 1 |
Ray, CA | 1 |
Delp, MD | 1 |
Israelsson, B | 1 |
Malmquist, J | 1 |
Kjellström, T | 1 |
Hu, Y | 1 |
Purushotham, KR | 1 |
Wang, P | 1 |
Dawson, R | 1 |
Humphreys-Beher, MG | 1 |
Ozüari, A | 1 |
Oztürk, Y | 1 |
Yildizoğlu-Ari, N | 1 |
Ozçelkay, AT | 1 |
Altan, VM | 1 |
Paolisso, G | 1 |
Tataranni, PA | 1 |
Foley, JE | 1 |
Bogardus, C | 1 |
Howard, BV | 1 |
Ravussin, E | 1 |
Gustavsson, J | 1 |
Parpal, S | 1 |
Strålfors, P | 1 |
Hellström, L | 1 |
Langin, D | 2 |
Reynisdottir, S | 2 |
Dauzats, M | 1 |
Arner, P | 2 |
Bányász, T | 1 |
Kalapos, I | 1 |
Kelemen, SZ | 1 |
Kovács, T | 1 |
Stenbit, AE | 1 |
Tsao, TS | 1 |
Li, J | 1 |
Burcelin, R | 1 |
Geenen, DL | 1 |
Factor, SM | 1 |
Houseknecht, K | 1 |
Katz, EB | 1 |
Charron, MJ | 1 |
Yu, ZW | 1 |
Jansson, PA | 1 |
Posner, BI | 1 |
Smith, U | 1 |
Eriksson, JW | 1 |
Gür, S | 1 |
Klannemark, M | 1 |
Orho, M | 1 |
Laurell, H | 1 |
Holm, C | 1 |
Groop, L | 1 |
Harada, K | 1 |
Ohmori, M | 1 |
Kitoh, Y | 1 |
Sugimoto, K | 1 |
Fujimura, A | 1 |
Blaak, EE | 3 |
Saris, WH | 2 |
Wolffenbuttel, BH | 2 |
Kemerink, GJ | 1 |
Pakbiers, MT | 1 |
Heidendal, GA | 1 |
Huisamen, B | 1 |
van Zyl, M | 1 |
Keyser, A | 1 |
Lochner, A | 1 |
Wagenmakers, AJ | 1 |
Belke, DD | 1 |
Halter, JB | 1 |
Porte, D | 1 |
Palmer, TM | 1 |
Taberner, PV | 1 |
Houslay, MD | 1 |
Schaffer, SW | 1 |
Allo, S | 1 |
Punna, S | 1 |
White, T | 1 |
Gøtzsche, O | 1 |
Panacek, EA | 1 |
Sherman, B | 1 |
Davidson, MB | 1 |
2 reviews available for isoproterenol and Diabetes Mellitus, Type 2
Article | Year |
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Early abnormalities in myocardial cell function in experimental diabetes.
Topics: Adenosine Triphosphate; Adult; Animals; Blood Glucose; Calcium; Calcium-Transporting ATPases; Catech | 1986 |
Pathogenesis of impaired glucose tolerance and type II diabetes mellitus--current status.
Topics: Administration, Oral; Blood Glucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Gl | 1985 |
39 other studies available for isoproterenol and Diabetes Mellitus, Type 2
Article | Year |
---|---|
Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.
Topics: Adipose Tissue; Adrenergic beta-Agonists; Animals; Diabetes Mellitus, Type 2; Hypoglycemic Agents; L | 1992 |
Discovery of novel thiourea derivatives as potent and selective beta3-adrenergic receptor agonists.
Topics: Adrenergic Agonists; Adrenergic beta-3 Receptor Antagonists; Animals; Diabetes Mellitus, Type 2; Hum | 2009 |
Cryo-EM structures of the β
Topics: Adrenergic beta-3 Receptor Agonists; Aniline Compounds; Benzoates; Biphenyl Compounds; Cryoelectron | 2022 |
Effects of Isoprenaline on ventricular myocyte shortening and Ca
Topics: Animals; Caffeine; Diabetes Mellitus; Diabetes Mellitus, Type 2; Isoproterenol; Myocytes, Cardiac; O | 2022 |
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Glucagon-Like Peptide-1 Receptor; Heart Injuries; | 2023 |
Obstructive sleep apnoea increases lipolysis and deteriorates glucose homeostasis in patients with type 2 diabetes mellitus.
Topics: Adipose Tissue; Aged; Diabetes Mellitus, Type 2; Epinephrine; Female; Glucose; Homeostasis; Humans; | 2021 |
β
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Blood Pressure; Diabetes Mellitus, Experimental; Dia | 2017 |
β
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Diabetes Mellitus, Type 2; Heart; He | 2019 |
[The influence of two-month treatment with bromocryptine on activity of the adenylyl cyclase signaling system in the myocardium and testes of rats with type 2 diabetes mellitus].
Topics: Adenylyl Cyclases; Administration, Oral; Animals; Blood Glucose; Bromocriptine; Diabetes Mellitus, E | 2014 |
Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes.
Topics: Adipocytes; Adipose Tissue; Adrenergic beta-Agonists; Aged; Blood Glucose; Carbon Radioisotopes; Cas | 2016 |
Cardioprotective effect of pioglitazone in diabetic and non-diabetic rats subjected to acute myocardial infarction involves suppression of AGE-RAGE axis and inhibition of apoptosis.
Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Cardiotonic Agents; Diabetes Mellitus, Type 2; Diabeti | 2016 |
Human mesenteric adipose tissue plays unique role versus subcutaneous and omental fat in obesity related diabetes.
Topics: Adiponectin; CD36 Antigens; Diabetes Mellitus, Type 2; Fatty Acids; Gene Expression Regulation; Glyc | 2008 |
Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity.
Topics: Adrenergic beta-Agonists; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Exercise; Gene | 2009 |
Chronic and acute exposure of mouse hearts to fatty acids increases oxygen cost of excitation-contraction coupling.
Topics: Animals; Basal Metabolism; Cardiotonic Agents; Diabetes Mellitus, Type 2; Disease Models, Animal; Do | 2011 |
GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice.
Topics: Animals; Diabetes Mellitus, Type 2; Glucose; Glutathione; Isoproterenol; Mice; Mitochondria; Models, | 2012 |
Curcumin attenuates lipolysis stimulated by tumor necrosis factor-α or isoproterenol in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Carrier Proteins; Curcuma; Curcumin; Diabetes Mellitus, Type 2; D | 2012 |
Impairment of the vascular relaxation and differential expression of caveolin-1 of the aorta of diabetic +db/+db mice.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Glucose; Blotting, Western; Caveolin 1; Cromakalim; D | 2006 |
Decreased NO signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertension.
Topics: Animals; Arterioles; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Disease Models, Anima | 2008 |
Cyclic AMP accumulation in human fibroblast cultures: diabetics compared with normals.
Topics: Adult; Cells, Cultured; Cyclic AMP; Diabetes Mellitus, Type 2; Fibroblasts; Humans; Isoproterenol; M | 1983 |
Downregulation of beta-adrenergic receptors and signal transduction response in salivary glands of NOD mice.
Topics: Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 2; Down-Regulatio | 1994 |
The effects of glyburide and insulin on the cardiac performance in rats with non-insulin-dependent diabetes mellitus.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dri | 1993 |
A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM.
Topics: Adipocytes; Adipose Tissue; Adult; Arizona; Biomarkers; Blood Glucose; Cells, Cultured; Confidence I | 1995 |
Insulin-stimulated glucose uptake involves the transition of glucose transporters to a caveolae-rich fraction within the plasma membrane: implications for type II diabetes.
Topics: Adenosine Deaminase; Adipocytes; Animals; Biological Transport; Cell Fractionation; Cell Membrane; C | 1996 |
Adipocyte lipolysis in normal weight subjects with obesity among first-degree relatives.
Topics: Adipocytes; Adrenergic beta-Agonists; Adult; Body Mass Index; Bucladesine; Clonidine; Colforsin; Dia | 1996 |
Changes in cardiac contractility in IDDM and NIDDM diabetic rats.
Topics: Animals; Cardiotonic Agents; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Me | 1996 |
GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes.
Topics: Animals; Blood Glucose; Blood Pressure; Deoxyglucose; Diabetes Mellitus, Type 2; Glucose Transporter | 1997 |
Peroxovanadate and insulin action in adipocytes from NIDDM patients. Evidence against a primary defect in tyrosine phosphorylation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; Adrenergic beta-Agonists; Adult; Animals; Blood | 1997 |
Effects of adenosine and isoprenaline in left atria from both neonatal and middle-aged noninsulin-dependent diabetic rat models.
Topics: Adenosine; Aging; Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Experimental; Diabete | 1997 |
The putative role of the hormone-sensitive lipase gene in the pathogenesis of Type II diabetes mellitus and abdominal obesity.
Topics: Abdomen; Adipose Tissue; Adrenergic beta-Agonists; Aged; Alleles; Body Constitution; Diabetes Mellit | 1998 |
Impaired beta-adrenoceptor mediated venodilation in patients with diabetes mellitus.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Glyburide; Humans; Isoproterenol; Male; Middle Aged; Nitrogl | 1999 |
Substrate utilization and thermogenic responses to beta-adrenergic stimulation in obese subjects with NIDDM.
Topics: Adrenergic beta-Agonists; Blood Glucose; Body Composition; Body Temperature Regulation; Diabetes Mel | 1999 |
Microdialysis assessment of local adipose tissue lipolysis during beta-adrenergic stimulation in upper-body-obese subjects with type II diabetes.
Topics: Adipose Tissue; Adrenergic beta-Agonists; Blood Glucose; Diabetes Mellitus, Type 2; Energy Metabolis | 1999 |
The effects of insulin and beta-adrenergic stimulation on glucose transport, glut 4 and PKB activation in the myocardium of lean and obese non-insulin dependent diabetes mellitus rats.
Topics: Adrenergic beta-Agonists; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mell | 2001 |
The fate of [U-(13)C]palmitate extracted by skeletal muscle in subjects with type 2 diabetes and control subjects.
Topics: Adrenergic beta-Agonists; Arteries; Blood Flow Velocity; Carbon Dioxide; Carbon Isotopes; Diabetes M | 2002 |
Cardiac function in perfused hearts from diabetic mice.
Topics: Animals; Diabetes Mellitus, Type 2; Heart; In Vitro Techniques; Isoproterenol; Mice; Mice, Inbred C5 | 2001 |
Mechanisms of impaired acute insulin release in adult onset diabetes: studies with isoproterenol and secretin.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Humans; Insulin; Insulin Sec | 1978 |
Alterations in G-protein expression, Gi function and stimulatory receptor-mediated regulation of adipocyte adenylyl cyclase in a model of insulin-resistant diabetes with obesity.
Topics: Adenylyl Cyclases; Adipose Tissue; Animals; Cell Membrane; Cells, Cultured; Colforsin; Diabetes Mell | 1992 |
Defective response to cAMP-dependent protein kinase in non-insulin-dependent diabetic heart.
Topics: Adenylyl Cyclases; Animals; Animals, Newborn; Calcium; Cells, Cultured; Cyclic AMP; Diabetes Mellitu | 1991 |
Lactic acidosis and insulin resistance associated with epinephrine in a patient with noninsulin-dependent diabetes mellitus.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Epinephrine; Humans; Insulin Resistance; Isoprot | 1988 |