isoproterenol has been researched along with Diabetes Mellitus, Adult-Onset in 41 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This work investigated the protective effect of pioglitazone on myocardial infarction (MI) in non-diabetic and diabetic rats, focusing on its role on advanced glycated endproducts (AGEs) and cardiac apoptotic machinery." | 7.83 | Cardioprotective effect of pioglitazone in diabetic and non-diabetic rats subjected to acute myocardial infarction involves suppression of AGE-RAGE axis and inhibition of apoptosis. ( Farag, NE; Khodeer, DM; Moustafa, YM; Zaitone, SA, 2016) |
| " This work investigated the protective effect of pioglitazone on myocardial infarction (MI) in non-diabetic and diabetic rats, focusing on its role on advanced glycated endproducts (AGEs) and cardiac apoptotic machinery." | 3.83 | Cardioprotective effect of pioglitazone in diabetic and non-diabetic rats subjected to acute myocardial infarction involves suppression of AGE-RAGE axis and inhibition of apoptosis. ( Farag, NE; Khodeer, DM; Moustafa, YM; Zaitone, SA, 2016) |
| "Curcumin, an active component derived from dietary spice turmeric (Curcuma longa), has been demonstrated antihyperglycemic, antiinflammatory and hypocholesterolemic activities in obesity and diabetes." | 3.78 | Curcumin attenuates lipolysis stimulated by tumor necrosis factor-α or isoproterenol in 3T3-L1 adipocytes. ( Kong, PR; Li, Y; Li, YX; Wu, JF; Xie, XY, 2012) |
| "In the search for potent and selective human beta3-adrenergic receptor (AR) agonists as potential drugs for the treatment of obesity and noninsulin-dependent (type II) diabetes, we prepared a novel series of phenoxypropanolamine derivatives containing the thiourea moiety and evaluated their biological activities at human beta3-, beta2-, and beta1-ARs." | 3.75 | Discovery of novel thiourea derivatives as potent and selective beta3-adrenergic receptor agonists. ( Hayakawa, M; Kawazoe, S; Maruyama, T; Matsui, T; Ohta, M; Onda, K; Seki, N; Suzuki, T; Takasu, T, 2009) |
| "Obesity is an important risk factor for diabetes mellitus (DM) which is a major global health problem." | 1.72 | Effects of Isoprenaline on ventricular myocyte shortening and Ca ( Howarth, FC; Qureshi, MA; Sultan, A, 2022) |
| "Type 2 diabetes mellitus is a complex metabolic disease, and cardiovascular disease is a leading complication of diabetes." | 1.43 | Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes. ( Antunes, M; Burgeiro, A; Carvalho, E; Carvalho, RA; Cherian, S; Espinoza, D; Fuhrmann, A; Jarak, I; Loureiro, M; Patrício, M, 2016) |
| "One of the common complications of type 2 diabetes mellitus (DM2) are cardiovascular diseases and dysfunctions of the reproductive system, indicating the urgency of developing new approaches to their correction." | 1.40 | [The influence of two-month treatment with bromocryptine on activity of the adenylyl cyclase signaling system in the myocardium and testes of rats with type 2 diabetes mellitus]. ( Bondareva, VM; Derkach, KV; Moyseyuk, IV; Shpakov, AO, 2014) |
| "Obesity is a common and rapidly growing health problem today." | 1.35 | Human mesenteric adipose tissue plays unique role versus subcutaneous and omental fat in obesity related diabetes. ( Abrams, GA; Aprahamian, CJ; Chen, M; Clements, RH; Harmon, CM; Yang, YK, 2008) |
| "Approximately 40% of patients with type 2 diabetes present with concurrent hypertension at the time of diabetes diagnosis." | 1.35 | Decreased NO signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertension. ( Behnke, BJ; Delp, MD; Donato, AJ; Laughlin, MH; Lesniewski, LA; Ray, CA; Woodman, CR, 2008) |
| "6." | 1.29 | The effects of glyburide and insulin on the cardiac performance in rats with non-insulin-dependent diabetes mellitus. ( Altan, VM; Ozçelkay, AT; Oztürk, Y; Ozüari, A; Yildizoğlu-Ari, N, 1993) |
| "Risk factors for NIDDM were estimated by proportional-hazards analysis and risk ratios (RR) with 95% confidence intervals (95% CI) calculated at the 90th and 10th percentile of the predictor variables." | 1.29 | A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM. ( Bogardus, C; Foley, JE; Howard, BV; Paolisso, G; Ravussin, E; Tataranni, PA, 1995) |
| "Treatment with isoproterenol plus adenosine deaminase rapidly inhibited insulin-stimulated glucose transport by 40%, and at the same time GLUT4 disappeared from the caveolae-rich fraction and from plasma membranes as a whole." | 1.29 | Insulin-stimulated glucose uptake involves the transition of glucose transporters to a caveolae-rich fraction within the plasma membrane: implications for type II diabetes. ( Gustavsson, J; Parpal, S; Strålfors, P, 1996) |
| " In order to evaluate the importance of the Iso dose, dose-response studies were performed in 9 diabetics (fasting plasma glucose greater than 150 mg/dl) and 10 age-matched controls." | 1.26 | Mechanisms of impaired acute insulin release in adult onset diabetes: studies with isoproterenol and secretin. ( Halter, JB; Porte, D, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (12.20) | 18.7374 |
| 1990's | 16 (39.02) | 18.2507 |
| 2000's | 8 (19.51) | 29.6817 |
| 2010's | 8 (19.51) | 24.3611 |
| 2020's | 4 (9.76) | 2.80 |
| Authors | Studies |
|---|---|
| Bloom, JD | 1 |
| Dutia, MD | 1 |
| Johnson, BD | 1 |
| Wissner, A | 1 |
| Burns, MG | 1 |
| Largis, EE | 1 |
| Dolan, JA | 1 |
| Claus, TH | 1 |
| Maruyama, T | 1 |
| Seki, N | 1 |
| Onda, K | 1 |
| Suzuki, T | 1 |
| Kawazoe, S | 1 |
| Hayakawa, M | 1 |
| Matsui, T | 1 |
| Takasu, T | 1 |
| Ohta, M | 1 |
| Nureki, I | 1 |
| Kobayashi, K | 1 |
| Tanaka, T | 1 |
| Demura, K | 1 |
| Inoue, A | 1 |
| Shihoya, W | 1 |
| Nureki, O | 1 |
| Sultan, A | 1 |
| Qureshi, MA | 1 |
| Howarth, FC | 1 |
| Bajic, Z | 1 |
| Sobot, T | 1 |
| Uletilovic, S | 1 |
| Mandic-Kovacevic, N | 1 |
| Cvjetkovic, T | 1 |
| Malicevic, U | 1 |
| Djukanovic, D | 1 |
| Duran, M | 1 |
| Vesic, N | 1 |
| Avram, S | 1 |
| Jovicic, S | 1 |
| Katana, M | 1 |
| Matavulj, A | 1 |
| Ponorac, N | 1 |
| Djuric, DM | 1 |
| Stojiljkovic, MP | 1 |
| Skrbić, R | 1 |
| Trinh, MD | 1 |
| Plihalova, A | 1 |
| Gojda, J | 1 |
| Westlake, K | 1 |
| Spicka, J | 1 |
| Lattova, Z | 1 |
| Pretl, M | 1 |
| Polak, J | 1 |
| Cook, RF | 2 |
| Bussey, CT | 2 |
| Mellor, KM | 1 |
| Cragg, PA | 2 |
| Lamberts, RR | 2 |
| Fomison-Nurse, IC | 1 |
| Hughes, G | 1 |
| Bahn, A | 1 |
| Derkach, KV | 1 |
| Bondareva, VM | 1 |
| Moyseyuk, IV | 1 |
| Shpakov, AO | 1 |
| Burgeiro, A | 1 |
| Fuhrmann, A | 1 |
| Cherian, S | 1 |
| Espinoza, D | 1 |
| Jarak, I | 1 |
| Carvalho, RA | 1 |
| Loureiro, M | 1 |
| Patrício, M | 1 |
| Antunes, M | 1 |
| Carvalho, E | 1 |
| Khodeer, DM | 1 |
| Zaitone, SA | 1 |
| Farag, NE | 1 |
| Moustafa, YM | 1 |
| Yang, YK | 1 |
| Chen, M | 1 |
| Clements, RH | 1 |
| Abrams, GA | 1 |
| Aprahamian, CJ | 1 |
| Harmon, CM | 1 |
| Lessard, SJ | 1 |
| Rivas, DA | 1 |
| Chen, ZP | 1 |
| van Denderen, BJ | 1 |
| Watt, MJ | 1 |
| Koch, LG | 1 |
| Britton, SL | 1 |
| Kemp, BE | 1 |
| Hawley, JA | 1 |
| Boardman, NT | 1 |
| Larsen, TS | 2 |
| Severson, DL | 2 |
| Essop, MF | 1 |
| Aasum, E | 1 |
| Tocchetti, CG | 1 |
| Caceres, V | 1 |
| Stanley, BA | 1 |
| Xie, C | 1 |
| Shi, S | 1 |
| Watson, WH | 1 |
| O'Rourke, B | 1 |
| Spadari-Bratfisch, RC | 1 |
| Cortassa, S | 1 |
| Akar, FG | 1 |
| Paolocci, N | 1 |
| Aon, MA | 1 |
| Xie, XY | 1 |
| Kong, PR | 1 |
| Wu, JF | 1 |
| Li, Y | 1 |
| Li, YX | 1 |
| Lam, TY | 1 |
| Seto, SW | 1 |
| Lau, YM | 1 |
| Au, LS | 1 |
| Kwan, YW | 1 |
| Ngai, SM | 1 |
| Tsui, KW | 1 |
| Lesniewski, LA | 1 |
| Donato, AJ | 1 |
| Behnke, BJ | 1 |
| Woodman, CR | 1 |
| Laughlin, MH | 1 |
| Ray, CA | 1 |
| Delp, MD | 1 |
| Israelsson, B | 1 |
| Malmquist, J | 1 |
| Kjellström, T | 1 |
| Hu, Y | 1 |
| Purushotham, KR | 1 |
| Wang, P | 1 |
| Dawson, R | 1 |
| Humphreys-Beher, MG | 1 |
| Ozüari, A | 1 |
| Oztürk, Y | 1 |
| Yildizoğlu-Ari, N | 1 |
| Ozçelkay, AT | 1 |
| Altan, VM | 1 |
| Paolisso, G | 1 |
| Tataranni, PA | 1 |
| Foley, JE | 1 |
| Bogardus, C | 1 |
| Howard, BV | 1 |
| Ravussin, E | 1 |
| Gustavsson, J | 1 |
| Parpal, S | 1 |
| Strålfors, P | 1 |
| Hellström, L | 1 |
| Langin, D | 2 |
| Reynisdottir, S | 2 |
| Dauzats, M | 1 |
| Arner, P | 2 |
| Bányász, T | 1 |
| Kalapos, I | 1 |
| Kelemen, SZ | 1 |
| Kovács, T | 1 |
| Stenbit, AE | 1 |
| Tsao, TS | 1 |
| Li, J | 1 |
| Burcelin, R | 1 |
| Geenen, DL | 1 |
| Factor, SM | 1 |
| Houseknecht, K | 1 |
| Katz, EB | 1 |
| Charron, MJ | 1 |
| Yu, ZW | 1 |
| Jansson, PA | 1 |
| Posner, BI | 1 |
| Smith, U | 1 |
| Eriksson, JW | 1 |
| Gür, S | 1 |
| Klannemark, M | 1 |
| Orho, M | 1 |
| Laurell, H | 1 |
| Holm, C | 1 |
| Groop, L | 1 |
| Harada, K | 1 |
| Ohmori, M | 1 |
| Kitoh, Y | 1 |
| Sugimoto, K | 1 |
| Fujimura, A | 1 |
| Blaak, EE | 3 |
| Saris, WH | 2 |
| Wolffenbuttel, BH | 2 |
| Kemerink, GJ | 1 |
| Pakbiers, MT | 1 |
| Heidendal, GA | 1 |
| Huisamen, B | 1 |
| van Zyl, M | 1 |
| Keyser, A | 1 |
| Lochner, A | 1 |
| Wagenmakers, AJ | 1 |
| Belke, DD | 1 |
| Halter, JB | 1 |
| Porte, D | 1 |
| Palmer, TM | 1 |
| Taberner, PV | 1 |
| Houslay, MD | 1 |
| Schaffer, SW | 1 |
| Allo, S | 1 |
| Punna, S | 1 |
| White, T | 1 |
| Gøtzsche, O | 1 |
| Panacek, EA | 1 |
| Sherman, B | 1 |
| Davidson, MB | 1 |
2 reviews available for isoproterenol and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Early abnormalities in myocardial cell function in experimental diabetes.
Topics: Adenosine Triphosphate; Adult; Animals; Blood Glucose; Calcium; Calcium-Transporting ATPases; Catech | 1986 |
Pathogenesis of impaired glucose tolerance and type II diabetes mellitus--current status.
Topics: Administration, Oral; Blood Glucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Gl | 1985 |
39 other studies available for isoproterenol and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.
Topics: Adipose Tissue; Adrenergic beta-Agonists; Animals; Diabetes Mellitus, Type 2; Hypoglycemic Agents; L | 1992 |
Discovery of novel thiourea derivatives as potent and selective beta3-adrenergic receptor agonists.
Topics: Adrenergic Agonists; Adrenergic beta-3 Receptor Antagonists; Animals; Diabetes Mellitus, Type 2; Hum | 2009 |
Cryo-EM structures of the β
Topics: Adrenergic beta-3 Receptor Agonists; Aniline Compounds; Benzoates; Biphenyl Compounds; Cryoelectron | 2022 |
Effects of Isoprenaline on ventricular myocyte shortening and Ca
Topics: Animals; Caffeine; Diabetes Mellitus; Diabetes Mellitus, Type 2; Isoproterenol; Myocytes, Cardiac; O | 2022 |
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Glucagon-Like Peptide-1 Receptor; Heart Injuries; | 2023 |
Obstructive sleep apnoea increases lipolysis and deteriorates glucose homeostasis in patients with type 2 diabetes mellitus.
Topics: Adipose Tissue; Aged; Diabetes Mellitus, Type 2; Epinephrine; Female; Glucose; Homeostasis; Humans; | 2021 |
β
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Blood Pressure; Diabetes Mellitus, Experimental; Dia | 2017 |
β
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Diabetes Mellitus, Type 2; Heart; He | 2019 |
[The influence of two-month treatment with bromocryptine on activity of the adenylyl cyclase signaling system in the myocardium and testes of rats with type 2 diabetes mellitus].
Topics: Adenylyl Cyclases; Administration, Oral; Animals; Blood Glucose; Bromocriptine; Diabetes Mellitus, E | 2014 |
Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes.
Topics: Adipocytes; Adipose Tissue; Adrenergic beta-Agonists; Aged; Blood Glucose; Carbon Radioisotopes; Cas | 2016 |
Cardioprotective effect of pioglitazone in diabetic and non-diabetic rats subjected to acute myocardial infarction involves suppression of AGE-RAGE axis and inhibition of apoptosis.
Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Cardiotonic Agents; Diabetes Mellitus, Type 2; Diabeti | 2016 |
Human mesenteric adipose tissue plays unique role versus subcutaneous and omental fat in obesity related diabetes.
Topics: Adiponectin; CD36 Antigens; Diabetes Mellitus, Type 2; Fatty Acids; Gene Expression Regulation; Glyc | 2008 |
Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity.
Topics: Adrenergic beta-Agonists; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Exercise; Gene | 2009 |
Chronic and acute exposure of mouse hearts to fatty acids increases oxygen cost of excitation-contraction coupling.
Topics: Animals; Basal Metabolism; Cardiotonic Agents; Diabetes Mellitus, Type 2; Disease Models, Animal; Do | 2011 |
GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice.
Topics: Animals; Diabetes Mellitus, Type 2; Glucose; Glutathione; Isoproterenol; Mice; Mitochondria; Models, | 2012 |
Curcumin attenuates lipolysis stimulated by tumor necrosis factor-α or isoproterenol in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Carrier Proteins; Curcuma; Curcumin; Diabetes Mellitus, Type 2; D | 2012 |
Impairment of the vascular relaxation and differential expression of caveolin-1 of the aorta of diabetic +db/+db mice.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Glucose; Blotting, Western; Caveolin 1; Cromakalim; D | 2006 |
Decreased NO signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertension.
Topics: Animals; Arterioles; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Disease Models, Anima | 2008 |
Cyclic AMP accumulation in human fibroblast cultures: diabetics compared with normals.
Topics: Adult; Cells, Cultured; Cyclic AMP; Diabetes Mellitus, Type 2; Fibroblasts; Humans; Isoproterenol; M | 1983 |
Downregulation of beta-adrenergic receptors and signal transduction response in salivary glands of NOD mice.
Topics: Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 2; Down-Regulatio | 1994 |
The effects of glyburide and insulin on the cardiac performance in rats with non-insulin-dependent diabetes mellitus.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dri | 1993 |
A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM.
Topics: Adipocytes; Adipose Tissue; Adult; Arizona; Biomarkers; Blood Glucose; Cells, Cultured; Confidence I | 1995 |
Insulin-stimulated glucose uptake involves the transition of glucose transporters to a caveolae-rich fraction within the plasma membrane: implications for type II diabetes.
Topics: Adenosine Deaminase; Adipocytes; Animals; Biological Transport; Cell Fractionation; Cell Membrane; C | 1996 |
Adipocyte lipolysis in normal weight subjects with obesity among first-degree relatives.
Topics: Adipocytes; Adrenergic beta-Agonists; Adult; Body Mass Index; Bucladesine; Clonidine; Colforsin; Dia | 1996 |
Changes in cardiac contractility in IDDM and NIDDM diabetic rats.
Topics: Animals; Cardiotonic Agents; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Me | 1996 |
GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes.
Topics: Animals; Blood Glucose; Blood Pressure; Deoxyglucose; Diabetes Mellitus, Type 2; Glucose Transporter | 1997 |
Peroxovanadate and insulin action in adipocytes from NIDDM patients. Evidence against a primary defect in tyrosine phosphorylation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; Adrenergic beta-Agonists; Adult; Animals; Blood | 1997 |
Effects of adenosine and isoprenaline in left atria from both neonatal and middle-aged noninsulin-dependent diabetic rat models.
Topics: Adenosine; Aging; Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Experimental; Diabete | 1997 |
The putative role of the hormone-sensitive lipase gene in the pathogenesis of Type II diabetes mellitus and abdominal obesity.
Topics: Abdomen; Adipose Tissue; Adrenergic beta-Agonists; Aged; Alleles; Body Constitution; Diabetes Mellit | 1998 |
Impaired beta-adrenoceptor mediated venodilation in patients with diabetes mellitus.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Glyburide; Humans; Isoproterenol; Male; Middle Aged; Nitrogl | 1999 |
Substrate utilization and thermogenic responses to beta-adrenergic stimulation in obese subjects with NIDDM.
Topics: Adrenergic beta-Agonists; Blood Glucose; Body Composition; Body Temperature Regulation; Diabetes Mel | 1999 |
Microdialysis assessment of local adipose tissue lipolysis during beta-adrenergic stimulation in upper-body-obese subjects with type II diabetes.
Topics: Adipose Tissue; Adrenergic beta-Agonists; Blood Glucose; Diabetes Mellitus, Type 2; Energy Metabolis | 1999 |
The effects of insulin and beta-adrenergic stimulation on glucose transport, glut 4 and PKB activation in the myocardium of lean and obese non-insulin dependent diabetes mellitus rats.
Topics: Adrenergic beta-Agonists; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mell | 2001 |
The fate of [U-(13)C]palmitate extracted by skeletal muscle in subjects with type 2 diabetes and control subjects.
Topics: Adrenergic beta-Agonists; Arteries; Blood Flow Velocity; Carbon Dioxide; Carbon Isotopes; Diabetes M | 2002 |
Cardiac function in perfused hearts from diabetic mice.
Topics: Animals; Diabetes Mellitus, Type 2; Heart; In Vitro Techniques; Isoproterenol; Mice; Mice, Inbred C5 | 2001 |
Mechanisms of impaired acute insulin release in adult onset diabetes: studies with isoproterenol and secretin.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Humans; Insulin; Insulin Sec | 1978 |
Alterations in G-protein expression, Gi function and stimulatory receptor-mediated regulation of adipocyte adenylyl cyclase in a model of insulin-resistant diabetes with obesity.
Topics: Adenylyl Cyclases; Adipose Tissue; Animals; Cell Membrane; Cells, Cultured; Colforsin; Diabetes Mell | 1992 |
Defective response to cAMP-dependent protein kinase in non-insulin-dependent diabetic heart.
Topics: Adenylyl Cyclases; Animals; Animals, Newborn; Calcium; Cells, Cultured; Cyclic AMP; Diabetes Mellitu | 1991 |
Lactic acidosis and insulin resistance associated with epinephrine in a patient with noninsulin-dependent diabetes mellitus.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Epinephrine; Humans; Insulin Resistance; Isoprot | 1988 |