isoproterenol has been researched along with Depressive Disorder in 16 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 17-year-old male with anorexia nervosa developed atypical prolongation of his corrected QT interval (QTc) when placed on isoproterenol for profound sinus bradycardia." | 7.68 | QT prolongation by isoproterenol in anorexia nervosa. ( Harris, JP; Kreipe, RE; Rossbach, CN, 1993) |
| "in seven male depressed patients with melancholia and five healthy male control subjects." | 5.27 | Patterns of melatonin rhythms in depression. ( Amsterdam, J; Brown, R; Caroff, S; Frazer, A; Kocsis, J; Stokes, P; Sweeney, J; Winokur, A, 1986) |
| "A 17-year-old male with anorexia nervosa developed atypical prolongation of his corrected QT interval (QTc) when placed on isoproterenol for profound sinus bradycardia." | 3.68 | QT prolongation by isoproterenol in anorexia nervosa. ( Harris, JP; Kreipe, RE; Rossbach, CN, 1993) |
| "The cyclic adenosine monophosphate (cAMP) responses to histamine, prostaglandin-E1, and isoproterenol in polymorphonuclear leukocytes from drug-free normal controls and patients with schizophrenia or major depressive disorder were compared." | 3.67 | Cyclic-AMP production by polymorphonuclear leukocytes in psychiatric disorders. ( Coccaro, EF; Davidson, M; Davis, KL; Johns, CA; Kanof, PD; Siever, LJ, 1989) |
| " Dose-response curves on cyclic AMP mediated activation of PKA confirmed the previously reported reduction in activation of PKA in patients with major depression but demonstrated that this reduction occurs without a change in the EC50 values of cyclic AMP (approximately 20 nmol/L)." | 1.29 | Beta-adrenoceptor-linked protein kinase A (PKA) activity in human fibroblasts from normal subjects and from patients with major depression. ( Eiring, A; Manier, DH; Shelton, RC; Sulser, F, 1996) |
| " We now report results of isoproterenol dose-response studies that indicate lower basal levels of cyclic AMP as well as diminished cyclic AMP levels in response to isoproterenol stimulation at concentrations ranging from 10(-10) to 10(-5) mol/L in drug-free, hospitalized patients with endogenous depression." | 1.27 | Blunted beta-adrenergic responsivity of peripheral blood mononuclear cells in endogenous depression. Isoproterenol dose-response studies. ( Brown, RP; Halper, JP; Kocsis, JH; Mann, JJ; Peters, A; Sweeney, JA, 1988) |
| "Late-night (terminal) insomnia was significantly associated with the blunted response to beta-adrenergic stimulation." | 1.27 | Cyclic AMP second-messenger signal amplification in depression. ( Ebstein, RP; Kindler, S; Lerer, B; Moscovich, DG; Shapira, B; Shemesh, Z, 1988) |
| "We found that drug-free inpatients with endogenous depression had lower isoproterenol-stimulated cyclic AMP levels in intact lymphocytes than did healthy control subjects (3." | 1.27 | Reduced sensitivity of lymphocyte beta-adrenergic receptors in patients with endogenous depression and psychomotor agitation. ( Bilezikian, JP; Brown, RP; Halper, JP; Kocsis, JH; Mann, JJ; Stokes, PE; Sweeney, JA, 1985) |
| "in seven male depressed patients with melancholia and five healthy male control subjects." | 1.27 | Patterns of melatonin rhythms in depression. ( Amsterdam, J; Brown, R; Caroff, S; Frazer, A; Kocsis, J; Stokes, P; Sweeney, J; Winokur, A, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (56.25) | 18.7374 |
| 1990's | 7 (43.75) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nurse, B | 1 |
| Russell, VA | 1 |
| Taljaard, JJ | 1 |
| Harris, JP | 1 |
| Kreipe, RE | 1 |
| Rossbach, CN | 1 |
| Avissar, S | 2 |
| Schreiber, G | 2 |
| Manier, DH | 1 |
| Eiring, A | 1 |
| Shelton, RC | 1 |
| Sulser, F | 2 |
| Mann, JJ | 4 |
| Halper, JP | 4 |
| Wilner, PJ | 2 |
| Sweeney, JA | 3 |
| Mieczkowski, TA | 1 |
| Chen, JS | 2 |
| Stokes, PE | 2 |
| Brown, RP | 4 |
| Nechamkin, Y | 1 |
| Roitman, G | 1 |
| Extein, I | 1 |
| Tallman, J | 1 |
| Smith, CC | 1 |
| Goodwin, FK | 1 |
| Mahler, JC | 1 |
| Johnson, KS | 1 |
| Kocsis, JH | 3 |
| Bertschy, G | 2 |
| Vandel, S | 2 |
| Puech, A | 2 |
| Blum, D | 1 |
| Vandel, B | 2 |
| Allers, G | 2 |
| Kanof, PD | 1 |
| Coccaro, EF | 1 |
| Johns, CA | 1 |
| Davidson, M | 1 |
| Siever, LJ | 1 |
| Davis, KL | 1 |
| Sandoz, M | 1 |
| Peters, A | 1 |
| Ebstein, RP | 1 |
| Lerer, B | 1 |
| Shapira, B | 1 |
| Shemesh, Z | 1 |
| Moscovich, DG | 1 |
| Kindler, S | 1 |
| Bilezikian, JP | 1 |
| Frazer, A | 1 |
| Brown, R | 1 |
| Kocsis, J | 1 |
| Caroff, S | 1 |
| Amsterdam, J | 1 |
| Winokur, A | 1 |
| Sweeney, J | 1 |
| Stokes, P | 1 |
1 trial available for isoproterenol and Depressive Disorder
| Article | Year |
|---|---|
Changes in lymphocyte beta-adrenergic receptors in depression and mania.
Topics: Adult; Bipolar Disorder; Clinical Trials as Topic; Cyclic AMP; Depressive Disorder; Desipramine; Dih | 1979 |
15 other studies available for isoproterenol and Depressive Disorder
| Article | Year |
|---|---|
Alpha 2 and beta-adrenoceptor agonists modulate [3H]dopamine release from rat nucleus accumbens slices: implications for research into depression.
Topics: Animals; Calcium; Clonidine; Depressive Disorder; Dopamine; Humans; In Vitro Techniques; Isoproteren | 1984 |
QT prolongation by isoproterenol in anorexia nervosa.
Topics: Adolescent; Anorexia Nervosa; Depressive Disorder; Electrocardiography; Heart Rate; Humans; Infusion | 1993 |
Measurement of early events in signal transduction beyond receptors involving G proteins function in mononuclear leucocytes.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Adult; Aged; Carbachol; Depressive Disorder; Dopamine; | 1996 |
Beta-adrenoceptor-linked protein kinase A (PKA) activity in human fibroblasts from normal subjects and from patients with major depression.
Topics: Adrenergic beta-Agonists; Adult; Case-Control Studies; Cyclic AMP; Cyclic AMP-Dependent Protein Kina | 1996 |
Subsensitivity of adenylyl cyclase-coupled receptors on mononuclear leukocytes from drug-free inpatients with a major depressive episode.
Topics: Adenylyl Cyclases; Adolescent; Adrenergic beta-Agonists; Adult; Age Distribution; Aged; Catecholamin | 1997 |
Dynamics of ECT normalization of low G protein function and immunoreactivity in mononuclear leukocytes of patients with major depression.
Topics: Biomarkers; Carbachol; Depressive Disorder; Electroconvulsive Therapy; GTP-Binding Proteins; Guanyly | 1998 |
Normalization of blunted lymphocyte beta-adrenergic responsivity in melancholic inpatients by a course of electroconvulsive therapy.
Topics: Cyclic AMP; Depressive Disorder; Down-Regulation; Electroconvulsive Therapy; Humans; Isoproterenol; | 1990 |
Desipramine induces cardiac beta-adrenergic sensitivity decrease in major depressed patients without relationship to therapeutic response.
Topics: Depressive Disorder; Desipramine; Down-Regulation; Heart; Heart Rate; Hospitalization; Humans; Isopr | 1990 |
Cyclic-AMP production by polymorphonuclear leukocytes in psychiatric disorders.
Topics: Adult; Alprostadil; Chronic Disease; Cimetidine; Cyclic AMP; Depressive Disorder; Female; Humans; Is | 1989 |
Cardiac beta-adrenergic sensitivity in depression: relation with endogenous subtype and desipramine response.
Topics: Adjustment Disorders; Arousal; Depressive Disorder; Desipramine; Electrocardiography, Ambulatory; He | 1989 |
Blunted beta-adrenergic responsivity of peripheral blood mononuclear cells in endogenous depression. Isoproterenol dose-response studies.
Topics: Adult; Aged; Cyclic AMP; Depressive Disorder; Dose-Response Relationship, Drug; Female; Hospitalizat | 1988 |
Cyclic AMP second-messenger signal amplification in depression.
Topics: Adult; Aged; Antidepressive Agents; Colforsin; Cyclic AMP; Depressive Disorder; Female; Humans; In V | 1988 |
Reduced sensitivity of lymphocyte beta-adrenergic receptors in patients with endogenous depression and psychomotor agitation.
Topics: Cyclic AMP; Depressive Disorder; Female; Humans; Hydrocortisone; In Vitro Techniques; Isoproterenol; | 1985 |
Serotonin-norepinephrine receptor interactions in the brain: implications for the pharmacology and pathophysiology of affective disorders.
Topics: Adenylyl Cyclases; Animals; Antidepressive Agents; Brain; Cyclic AMP; Depressive Disorder; Desiprami | 1987 |
Patterns of melatonin rhythms in depression.
Topics: Adult; Circadian Rhythm; Depression; Depressive Disorder; Desipramine; Female; Humans; Isoproterenol | 1986 |