isoproterenol has been researched along with Cystic Fibrosis in 133 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The peptide drug Moli1901 activates an alternative chloride channel that is present in cystic fibrosis (CF) nasal and airway epithelia." | 9.11 | A phase I trial of intranasal Moli1901 for cystic fibrosis. ( Boyle, MP; Guggino, WB; Molina, L; Zeitlin, PL, 2004) |
| "Previous studies have indicated that milrinone, a specific type III phosphodiesterase inhibitor, may be able to induce chloride secretion in cystic fibrosis (CF) tissues." | 7.70 | The in vivo effects of milrinone on the airways of cystic fibrosis mice and human subjects. ( Alton, EW; Bush, KA; Chadwick, S; Delaney, SJ; Farley, R; Geddes, DM; Jaffe, A; Middleton, PG; Rolleston, S; Smith, SN; Wainwright, B, 1999) |
| "Two experimental animal models exhibiting functional and morphologic changes of exocrine glands similar to those seen in patients with cystic fibrosis (CF) have been reported in the rat: chronic stimulation with reserpine (Martinez et al." | 7.67 | Pulmonary function of the reserpine and isoproterenol models of cystic fibrosis. ( Boyd, RL; Fletcher, MT; Francis, EM; Mangos, JA, 1984) |
| "The chronically isoproterenol-treated rat has been proposed as an animal model for cystic fibrosis." | 7.67 | The chronically isoproterenol-treated rat in the study of cystic fibrosis: X-ray microanalysis of the submandibular gland. ( Müller, RM; Roomans, GM, 1984) |
| "Thirteen cystic fibrosis and 12 normal strains of skin fibroblasts obtained from the Institute for Medical Research were compared for their degree of production of cyclic adenosine 3':5'-monophosphate in response to isoproterenol and prostaglandin E1." | 7.66 | Cystic fibrosis fibroblasts respond normally to isoproterenol. ( Kurz, JB; Perkins, JP, 1981) |
| "The effect of isoproterenol inhalations was studied on 95 occasions in 47 patients with cystic fibrosis." | 7.65 | The effect of isoproterenol on airway obstruction in cystic fibrosis. ( Featherby, EA; Levison, H; Weng, TR, 1970) |
| "Elevated calcium and protein concentration are a consistent abnormality in submaxillary saliva from patients with cystic fibrosis (CF) and from experimental animal models developed by the chronic administration of either isoproterenol (IPR) or reserpine." | 7.65 | The chronically reserpinized rat as a possible model for cystic fibrosis. VI. Synergistic effects of isoproterenol on Ca++ and protein in the submaxillary gland. ( Martinez, R; Wood, DL, 1977) |
| "To determine if the abnormalities of exocrine secretion characteristic of cystic fibrosis could be investigated in vitro, I studied the synthesis of 3':5'-cyclic AMP after isoproterenol stimulation in skin fibroblasts derived from patients with cystic fibrosis and from normal individuals." | 7.65 | Abnormal levels of 3':5'-cyclic AMP in isoproterenol-stimulated fibroblasts from patients with cystic fibrosis. ( Buchwald, M, 1976) |
| "Curcumin is a nontoxic Ca-adenosine triphosphatase pump inhibitor that can be administered to humans safely." | 5.32 | Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. ( Canny, S; Caplan, MJ; Du, K; Egan, ME; Glöckner-Pagel, J; Lukacs, GL; Pearson, M; Rajendran, V; Rubin, D; Weiner, SA, 2004) |
| "The peptide drug Moli1901 activates an alternative chloride channel that is present in cystic fibrosis (CF) nasal and airway epithelia." | 5.11 | A phase I trial of intranasal Moli1901 for cystic fibrosis. ( Boyle, MP; Guggino, WB; Molina, L; Zeitlin, PL, 2004) |
| "This study examined the effect of aerosolized isoproterenol and oral theophylline on pulmonary function in cystic fibrosis (CF) to determine how often these drugs are beneficial and whether there is a correlation between response to isoproterenol and response to oral theophylline." | 5.04 | The paradoxical effect of adrenergic and methylxanthine drugs in cystic fibrosis. ( Bamman, J; Bierman, CW; Kanarek, P; Shapiro, GG, 1976) |
| " Changes in nasal PD in response to amiloride, chloride-free medium, and chloride-free medium containing isoproterenol were measured, and responses of asthmatics and healthy control subjects were compared." | 3.72 | Measurement of nasal potential difference in mild asthmatics. ( Chung, NC; Fischer, H; Illek, B; Widdicombe, JH, 2003) |
| "We investigated cystic fibrosis (CF) transmembrane conductance regulator (CFTR) regulation by A2 adenosine (Ado) receptors and beta2 adrenergic receptors in CFTR-corrected CFBE41o- airway cells and human subjects." | 3.72 | Activation of airway cl- secretion in human subjects by adenosine. ( Clancy, JP; Cobb, B; Eubanks-Tarn, V; Fan, L; Hentchel-Franks, K; Lozano, D; Oster, R; Sorscher, E, 2004) |
| "Direct measurement of CFTR function in nasal epithelium in response to isoproterenol demonstrated that the values for PD/RAP were intermediate between those observed for healthy controls and cystic fibrosis patients." | 3.72 | Analysis of cystic fibrosis gener product (CFTR) function in patients with pancreas divisum and recurrent acute pancreatitis. ( Banerjee, S; Carr-Locke, DL; Chuttani, R; Durie, PR; Ellis, L; Freedman, SD; Gelrud, A; Howell, DA; Regan, MM; Shea, J; Sheth, S; Telford, JJ; Weed, D, 2004) |
| "Previous studies have indicated that milrinone, a specific type III phosphodiesterase inhibitor, may be able to induce chloride secretion in cystic fibrosis (CF) tissues." | 3.70 | The in vivo effects of milrinone on the airways of cystic fibrosis mice and human subjects. ( Alton, EW; Bush, KA; Chadwick, S; Delaney, SJ; Farley, R; Geddes, DM; Jaffe, A; Middleton, PG; Rolleston, S; Smith, SN; Wainwright, B, 1999) |
| " In our pursuit to identify potent modulators of Cl(-) secretion that may be useful to overcome the Cl(-) secretory defect in cystic fibrosis (CF), we have identified chlorzoxazone [5-chloro-2(3H)-benzoxazolone], a clinically used centrally acting muscle relaxant, as a stimulator of Cl(-) secretion in several epithelial cell types, including T84, Calu-3, and human bronchial epithelium." | 3.70 | Stimulation of Cl(-) secretion by chlorzoxazone. ( Bridges, RJ; Devor, DC; Gerlach, AC; Gondor, M; Pilewski, JM; Singh, AK, 2000) |
| " In cells prelabeled with [3H]arachidonic acid, alpha 1-AR agents produced a biphasic DG generation in normal and cystic fibrosis (CF) cells that is blocked by pertussis toxin." | 3.69 | The role of protein kinase C in alpha-adrenergic regulation of NaCl(K) cotransport in human airway epithelial cells. ( Liedtke, CM, 1995) |
| "In comparison to skin fibroblasts from normal subjects, those from patients with cystic fibrosis (CF): (1) bound [20-3H] phorbol 12,13-dibutyrate (PDBu) with a higher affinity Kd = 25." | 3.68 | Further evidence for abnormal protein kinase C regulation of macromolecule secretion in fibroblasts from cystic fibrosis patients. ( Bertrand, F; Capeau, J; Cherqui, G; Garcia, I; Hermelin, B; Paul, A; Picard, J, 1990) |
| " isoproterenol) to activate a specific apical membrane chloride channel in epithelial cells is characteristic of cystic fibrosis (CF)." | 3.68 | Chloride ion transport in transformed normal and cystic fibrosis epithelial cells. ( Chin, L; Cozens, AL; Friend, DS; Gruenert, DC; Simon, EM; Yezzi, MJ, 1991) |
| "To investigate cellular mechanisms involved in the regulation of basolateral Na-K-Cl cotransport in airway epithelia, we determined saturable basolateral [3H]bumetanide binding, a measure of functioning cotransporters, in primary cultures of canine tracheal and human nasal epithelial cells, including cells from patients with cystic fibrosis (CF)." | 3.68 | Dual mechanisms for Na-K-Cl cotransport regulation in airway epithelial cells. ( Haas, M; McBrayer, DG; Yankaskas, JR, 1993) |
| "Two experimental animal models exhibiting functional and morphologic changes of exocrine glands similar to those seen in patients with cystic fibrosis (CF) have been reported in the rat: chronic stimulation with reserpine (Martinez et al." | 3.67 | Pulmonary function of the reserpine and isoproterenol models of cystic fibrosis. ( Boyd, RL; Fletcher, MT; Francis, EM; Mangos, JA, 1984) |
| "Transepithelial potential difference (PD) of isolated segments of the secretory coil of both human control and cystic fibrosis (CF) eccrine sweat glands was measured during stimulation with methacholine (MCh) and isoproterenol (ISO) in vitro." | 3.67 | Differing luminal potential difference of cystic fibrosis and control sweat secretory coils in vitro. ( Sato, K, 1984) |
| "The chronically isoproterenol-treated rat has been proposed as an animal model for cystic fibrosis." | 3.67 | The chronically isoproterenol-treated rat in the study of cystic fibrosis: X-ray microanalysis of the submandibular gland. ( Müller, RM; Roomans, GM, 1984) |
| "The in-vitro investigation of secretory responses of submandibular tissues from three cystic fibrosis (CF) patients and four control subjects showed that responses to a beta-adrenergic stimulus (isoproterenol) were much poorer in CF cells than in control cells." | 3.67 | Defective beta-adrenergic secretory responses in submandibular acinar cells from cystic fibrosis patients. ( Bradbury, NA; Dodge, JA; Dormer, RL; Goodchild, MC; McPherson, MA, 1986) |
| "Airway reactivity to cold air and methacholine, alpha-adrenergic and cholinergic reactivity measured as pupillary responses to phenylephrine and carbachol, respectively, and beta-adrenergic reactivity assessed by lymphocyte adenosine 3',5'-cyclic monophosphate (cAMP) response to isoproterenol were compared in 108 parents of patients with cystic fibrosis (CF) and 133 healthy adult controls." | 3.67 | Heterozygotes for cystic fibrosis: models for study of airway and autonomic reactivity. ( Byard, PJ; Davis, PB, 1989) |
| "To determine whether epithelial ion transport abnormalities in cystic fibrosis (CF) might reflect abnormal regulation of intracellular Ca2+ levels, cytosolic free calcium (Cai2+) was measured using fura-2 or quin2 in suspensions of normal or CF nasal epithelial cells derived from primary cell culture." | 3.67 | Cell calcium levels of normal and cystic fibrosis nasal epithelium. ( Boucher, RC; Cheng, E; Murphy, E; Stutts, MJ; Yankaskas, J, 1988) |
| "Elemental distribution and ultrastructure of the submandibular gland, the parotid gland and the pancreas were investigated in three suggested animal models of the disease cystic fibrosis: the chronically reserpinized rat, the chronically isoproterenol-treated rat, and the chronically pilocarpine-treated rat." | 3.67 | X-ray microanalysis of exocrine glands in animal models for cystic fibrosis. ( Müller, RM; Roomans, GM, 1985) |
| "Because patients with cystic fibrosis (CF) consistently lack sweating response to isoproterenol (ISO) in vivo and in vitro, we studied to what extent beta-adrenergic defect is expressed in CF heterozygotes." | 3.67 | Variable reduction in beta-adrenergic sweat secretion in cystic fibrosis heterozygotes. ( Sato, F; Sato, K, 1988) |
| "Chronic treatment of rats with reserpine, isoproterenol, or a combination of these two agents has been suggested as a means to produce an experimental animal model for the chronic exocrinopathy cystic fibrosis." | 3.67 | Changes in glycoconjugates in rat submandibular gland after chronic treatment with reserpine and isoproterenol. ( Maltarello, MC; Müller, RM; Roomans, GM; Versura, P, 1988) |
| " For both normal and cystic fibrosis fibroblasts, the isoproterenol stimulation ratio was maximal 2 to 3 days after subculture and declined thereafter; prostaglandin E1 stimulation ratio was maximal 7 to 10 days after subculture." | 3.66 | Hormone-stimulated cyclic AMP production by skin fibroblasts cultured from healthy persons and patients with cystic fibrosis. ( Davis, PB; Hill, SC; Ulane, MM, 1980) |
| "The specific induction of alkaline phosphatase with Tamm-Horsfall glycoprotein, isoproterenol, and theophylline in skin-derived fibroblast cultures from patients with cystic fibrosis permits one to reliably discriminate between cystic fibrosis patients on the one hand, and heterozygotes and normals on the other." | 3.66 | Reliable detection of cystic fibrosis in skin-derived fibroblast cultures. ( Hösli, P; Vogt, E, 1978) |
| "Skin fibroblasts derived from 6 patients with cystic fibrosis (CF), 1-6 months old, and from 6 age matched donors were investigated for their ability to accumulate cyclic adenosine 3':5'-monophosphate (c-AMP) in response to isoproterenol and prostaglandin E1 (PGE1) using strictly defined culture conditions." | 3.66 | Enhanced adenosine 3':5' - monophosphate response to beta-adrenergic stimulation in cystic fibrosis fibroblasts after removal of conditioned medium. ( Hadorn, B; Roscher, AA; Schmid, AJ; Wiesmann, UN, 1980) |
| "Thirteen cystic fibrosis and 12 normal strains of skin fibroblasts obtained from the Institute for Medical Research were compared for their degree of production of cyclic adenosine 3':5'-monophosphate in response to isoproterenol and prostaglandin E1." | 3.66 | Cystic fibrosis fibroblasts respond normally to isoproterenol. ( Kurz, JB; Perkins, JP, 1981) |
| "Alkaline phosphatase (ALP) activities were compared in fibroblasts from three cystic fibrosis patients and two normal controls after culturing the cells in normal growth medium and in medium containing Tamm-Horsfall glycoprotein, isoproterenol, and theophylline." | 3.66 | Alkaline phosphatase activity of normal and cystic fibrosis fibroblasts. ( Aitken, DA; Hoogeveen, A, 1980) |
| "Granulocytes from 21 nonasthmatic cystic fibrosis (CF) patients were isolated and the effects of isoproterenol, histamine, and prostaglandin E1 upon zymosan-induced beta-glucuronidase release was measured." | 3.66 | Analysis of granulocyte beta-adrenergic response in cystic fibrosis: correlation of decreased responsiveness with disease severity. ( Anderson, C; Busse, WW; Farrell, PM; Lemanske, RF; Mischler, EH, 1981) |
| "Elevated calcium and protein concentration are a consistent abnormality in submaxillary saliva from patients with cystic fibrosis (CF) and from experimental animal models developed by the chronic administration of either isoproterenol (IPR) or reserpine." | 3.65 | The chronically reserpinized rat as a possible model for cystic fibrosis. VI. Synergistic effects of isoproterenol on Ca++ and protein in the submaxillary gland. ( Martinez, R; Wood, DL, 1977) |
| "Rats treated for 7 days with reserpine develop structural changes in the submaxillary gland that resemble those that have been reported in cystic fibrosis." | 3.65 | The chronically reserpinized rat as a possible model for cystic fibrosis. I. Submaxillary gland morphology and ultrastructure. ( Adelstein, E; Barbero, GJ; Martinez, JR; Quissel, D, 1975) |
| "To determine if the abnormalities of exocrine secretion characteristic of cystic fibrosis could be investigated in vitro, I studied the synthesis of 3':5'-cyclic AMP after isoproterenol stimulation in skin fibroblasts derived from patients with cystic fibrosis and from normal individuals." | 3.65 | Abnormal levels of 3':5'-cyclic AMP in isoproterenol-stimulated fibroblasts from patients with cystic fibrosis. ( Buchwald, M, 1976) |
| "The effect of isoproterenol inhalations was studied on 95 occasions in 47 patients with cystic fibrosis." | 3.65 | The effect of isoproterenol on airway obstruction in cystic fibrosis. ( Featherby, EA; Levison, H; Weng, TR, 1970) |
| "Submaxillary saliva from reserpine-treated rats was found to have alterations in composition similar to those reported in the same secretion from patients with cystic fibrosis." | 3.65 | The chronically reserpinized rat as a possible model for cystic fibrosis. II. Comparison and cilioinhibitory effects of submaxillary saliva. ( Adshead, PC; Barbero, GJ; Martinez, JR; Quissell, DO, 1975) |
| "Pilocarpine was used at a concentration ∼130-times lower than that used in the classical Gibson and Cooke sweat test." | 1.72 | Needle-free iontophoresis-driven β-adrenergic sweat rate test. ( Frédérick, R; Gohy, S; Leal, T; Lebecque, P; Mottais, A; Reynaerts, A; Vanbever, R; Vermeulen, F, 2022) |
| "Subclinical hypothyroidism has been linked to cystic fibrosis, and the cystic fibrosis transmembrane conductance regulator (CFTR) shown to be expressed in the thyroid." | 1.36 | Altered ion transport by thyroid epithelia from CFTR(-/-) pigs suggests mechanisms for hypothyroidism in cystic fibrosis. ( Fong, P; Ganta, S; Li, H, 2010) |
| "Curcumin is a nontoxic Ca-adenosine triphosphatase pump inhibitor that can be administered to humans safely." | 1.32 | Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. ( Canny, S; Caplan, MJ; Du, K; Egan, ME; Glöckner-Pagel, J; Lukacs, GL; Pearson, M; Rajendran, V; Rubin, D; Weiner, SA, 2004) |
| "Treatment with carbachol, calcium ionophores or phorbol ester did not acutely affect chloride efflux." | 1.29 | Effects of mutations in cAMP-dependent protein kinase on chloride efflux in Caco-2 human colonic carcinoma cells. ( Bear, CE; Krolczyk, AJ; Lai, PF; Schimmer, BP, 1995) |
| " No effects specific to cystic fibrosis serum were demonstrated using the following parameters for evaluation: (1) maximal stimulation of mucin release by a beta-adrenergic agonist, (-)-isoproterenol; (2) basal release (unstimulated secretion) of mucin material; and (3) the dose-response relationship for mucin release after beta-adrenergic receptor stimulation." | 1.27 | Effect of serum from normal and cystic fibrosis subjects on mucin secretion from dispersed rat submandibular cells. ( Barzen, KA; Deisher, LM; McDonald, RJ; Quissell, DO, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 69 (51.88) | 18.7374 |
| 1990's | 32 (24.06) | 18.2507 |
| 2000's | 18 (13.53) | 29.6817 |
| 2010's | 11 (8.27) | 24.3611 |
| 2020's | 3 (2.26) | 2.80 |
| Authors | Studies |
|---|---|
| Reynaerts, A | 1 |
| Vermeulen, F | 3 |
| Mottais, A | 1 |
| Gohy, S | 1 |
| Lebecque, P | 2 |
| Frédérick, R | 1 |
| Vanbever, R | 1 |
| Leal, T | 4 |
| Joo, NS | 3 |
| Cho, HJ | 2 |
| Shinbashi, M | 1 |
| Choi, JY | 1 |
| Milla, CE | 1 |
| Engelhardt, JF | 1 |
| Wine, JJ | 3 |
| Kyrilli, S | 1 |
| Henry, T | 1 |
| Wilschanski, M | 3 |
| Fajac, I | 1 |
| Davies, JC | 1 |
| Jais, JP | 1 |
| Sermet-Gaudelus, I | 2 |
| Matusovsky, OS | 2 |
| Kachmar, L | 2 |
| Ijpma, G | 1 |
| Panariti, A | 1 |
| Benedetti, A | 1 |
| Martin, JG | 2 |
| Lauzon, AM | 2 |
| Naehrlich, L | 1 |
| Ballmann, M | 1 |
| Davies, J | 1 |
| Derichs, N | 1 |
| Gonska, T | 2 |
| Hjelte, L | 1 |
| van Konigsbruggen-Rietschel, S | 1 |
| Melotti, P | 3 |
| Middleton, P | 1 |
| Tümmler, B | 1 |
| Char, JE | 1 |
| Chen, J | 1 |
| Dunn, C | 1 |
| Frisbee, E | 1 |
| Milla, C | 1 |
| Modlin, SE | 1 |
| Park, IH | 1 |
| Thomas, EA | 1 |
| Tran, KV | 1 |
| Verma, R | 1 |
| Wolfe, MH | 1 |
| Jeong, JH | 1 |
| Hwang, PH | 1 |
| Tridello, G | 1 |
| Menin, L | 1 |
| Pintani, E | 1 |
| Bergamini, G | 1 |
| Assael, BM | 1 |
| Ip, W | 1 |
| Turner, D | 1 |
| Han, WS | 1 |
| Rose, J | 1 |
| Durie, P | 1 |
| Quinton, P | 1 |
| Schmitt, L | 1 |
| Wiebel, M | 1 |
| Frese, F | 1 |
| Dehnert, C | 1 |
| Zugck, C | 1 |
| Bärtsch, P | 1 |
| Mairbäurl, H | 1 |
| Middleton, PG | 5 |
| House, HH | 1 |
| Li, H | 1 |
| Ganta, S | 1 |
| Fong, P | 1 |
| Finkbeiner, WE | 2 |
| Zlock, LT | 1 |
| Morikawa, M | 1 |
| Lao, AY | 1 |
| Dasari, V | 1 |
| Widdicombe, JH | 5 |
| Risse, PA | 1 |
| Novali, M | 1 |
| Gil, FR | 1 |
| Javeshghani, S | 1 |
| Keary, R | 1 |
| Haston, CK | 1 |
| Michoud, MC | 1 |
| Bronsveld, I | 1 |
| Sands, D | 1 |
| Leonard, A | 1 |
| Yaakov, Y | 1 |
| de Nooijer, R | 1 |
| De Boeck, K | 1 |
| Sermet, I | 1 |
| Lebacq, J | 1 |
| Cumps, J | 1 |
| Wallemacq, P | 1 |
| Trout, L | 1 |
| Townsley, MI | 1 |
| Bowden, AL | 1 |
| Ballard, ST | 1 |
| Chung, NC | 1 |
| Illek, B | 1 |
| Fischer, H | 1 |
| Boyle, MP | 2 |
| Diener-West, M | 2 |
| Milgram, L | 1 |
| Knowles, M | 1 |
| Foy, C | 1 |
| Zeitlin, P | 1 |
| Standaert, T | 1 |
| Pollard, KA | 1 |
| Donohoo, E | 1 |
| Wheatley, JR | 1 |
| Geddes, DM | 6 |
| Alton, EW | 7 |
| SNELL, JD | 1 |
| MATTHEWS, LW | 2 |
| DOERSHUK, CF | 3 |
| WISE, M | 1 |
| EDDY, G | 1 |
| NUDELMAN, H | 1 |
| SPECTOR, S | 1 |
| Zeitlin, PL | 2 |
| Guggino, WB | 1 |
| Molina, L | 1 |
| Hentchel-Franks, K | 1 |
| Lozano, D | 1 |
| Eubanks-Tarn, V | 1 |
| Cobb, B | 1 |
| Fan, L | 1 |
| Oster, R | 1 |
| Sorscher, E | 1 |
| Clancy, JP | 2 |
| Egan, ME | 2 |
| Pearson, M | 1 |
| Weiner, SA | 1 |
| Rajendran, V | 1 |
| Rubin, D | 1 |
| Glöckner-Pagel, J | 2 |
| Canny, S | 2 |
| Du, K | 1 |
| Lukacs, GL | 1 |
| Caplan, MJ | 2 |
| Gelrud, A | 1 |
| Sheth, S | 1 |
| Banerjee, S | 1 |
| Weed, D | 1 |
| Shea, J | 1 |
| Chuttani, R | 1 |
| Howell, DA | 1 |
| Telford, JJ | 1 |
| Carr-Locke, DL | 1 |
| Regan, MM | 1 |
| Ellis, L | 1 |
| Durie, PR | 1 |
| Freedman, SD | 1 |
| Best, JA | 1 |
| Quinton, PM | 1 |
| Davies, MG | 1 |
| Roussel, D | 1 |
| Bui, S | 1 |
| Deneuville, E | 1 |
| Huet, F | 1 |
| Reix, P | 1 |
| Bellon, G | 1 |
| Lenoir, G | 1 |
| Edelman, A | 1 |
| Hebestreit, A | 1 |
| Kersting, U | 1 |
| Hebestreit, H | 1 |
| Kurz, JB | 1 |
| Perkins, JP | 1 |
| Davis, PB | 7 |
| Shelhamer, JR | 1 |
| Kaliner, M | 2 |
| Roscher, AA | 2 |
| Schmid, AJ | 1 |
| Hadorn, B | 2 |
| Wiesmann, UN | 3 |
| Hill, SC | 1 |
| Ulane, MM | 1 |
| Honegger, UE | 1 |
| Dieckman, L | 1 |
| Boat, TF | 1 |
| Stern, RC | 1 |
| Fraser, CM | 1 |
| Venter, JC | 1 |
| Sato, K | 4 |
| Sato, F | 3 |
| Boyd, RL | 2 |
| Francis, EM | 1 |
| Fletcher, MT | 1 |
| Mangos, JA | 3 |
| Quissell, DO | 2 |
| McDonald, RJ | 1 |
| Barzen, KA | 1 |
| Deisher, LM | 1 |
| Müller, RM | 3 |
| Roomans, GM | 5 |
| Bouchlas, D | 1 |
| Farnham, W | 1 |
| Dantzker, DR | 1 |
| Patten, GA | 1 |
| Bower, JS | 1 |
| Lemanske, RF | 1 |
| Mischler, EH | 1 |
| Farrell, PM | 1 |
| Anderson, C | 1 |
| Busse, WW | 1 |
| Aitken, DA | 1 |
| Hoogeveen, A | 1 |
| Mawhinney, TP | 2 |
| Martinez, JR | 4 |
| Feather, MS | 2 |
| Barbero, GJ | 4 |
| Davies, H | 1 |
| Lewis, MJ | 1 |
| Goodchild, MC | 4 |
| McPherson, MA | 7 |
| Krolczyk, AJ | 1 |
| Bear, CE | 1 |
| Lai, PF | 1 |
| Schimmer, BP | 1 |
| Levesque, PC | 1 |
| Hume, JR | 1 |
| Knowles, MR | 6 |
| Paradiso, AM | 2 |
| Boucher, RC | 8 |
| Birnbaum, AK | 1 |
| Wotta, DR | 1 |
| Law, PY | 1 |
| Wilcox, GL | 1 |
| Cuthbert, AW | 1 |
| Halstead, J | 1 |
| Ratcliff, R | 1 |
| Colledge, WH | 1 |
| Evans, MJ | 1 |
| Liedtke, CM | 3 |
| Bernstein, JM | 1 |
| Yankaskas, JR | 4 |
| Tsang, VT | 1 |
| Hodson, ME | 2 |
| Yacoub, M | 2 |
| Haas, M | 1 |
| McBrayer, DG | 1 |
| Kelley, TJ | 1 |
| Al-Nakkash, L | 1 |
| Cotton, CU | 3 |
| Drumm, ML | 1 |
| Kester, M | 1 |
| Walker, LC | 1 |
| Venglarik, CJ | 1 |
| Aubin, G | 1 |
| Weatherly, MR | 1 |
| McCarty, NA | 1 |
| Lesnick, B | 1 |
| Ruiz, F | 1 |
| Sorscher, EJ | 1 |
| Ho, LP | 1 |
| Samways, JM | 1 |
| Porteous, DJ | 1 |
| Dorin, JR | 1 |
| Carothers, A | 1 |
| Greening, AP | 1 |
| Innes, JA | 1 |
| Kammouni, W | 1 |
| Figarella, C | 1 |
| Baeza, N | 1 |
| Marchand, S | 1 |
| Merten, MD | 1 |
| Pradal, U | 1 |
| Castellani, C | 1 |
| Delmarco, A | 1 |
| Mastella, G | 1 |
| Smith, SN | 1 |
| Chadwick, S | 1 |
| Jaffe, A | 2 |
| Bush, KA | 1 |
| Rolleston, S | 1 |
| Farley, R | 1 |
| Delaney, SJ | 1 |
| Wainwright, B | 1 |
| Danner, I | 1 |
| Boisseau, P | 1 |
| Chailleux, E | 1 |
| Escande, D | 1 |
| Thomas, SR | 1 |
| Singh, AK | 1 |
| Devor, DC | 1 |
| Gerlach, AC | 1 |
| Gondor, M | 1 |
| Pilewski, JM | 1 |
| Bridges, RJ | 1 |
| Callen, A | 1 |
| Rubenstein, RC | 1 |
| Pereira, MM | 2 |
| Russell, D | 1 |
| McNeilly, CM | 1 |
| Morris, RM | 1 |
| Stratford, FL | 1 |
| Dormer, RL | 6 |
| Ambrose, C | 1 |
| Cahill, PA | 1 |
| Pappoe, L | 1 |
| Balamuth, N | 1 |
| Cho, E | 1 |
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| Vayo, MM | 1 |
| Hösli, P | 2 |
| Kollberg, H | 1 |
| Vogt, E | 2 |
| Larsen, GL | 1 |
| Barron, RJ | 1 |
| Cotton, EK | 1 |
| Brooks, JG | 1 |
| Shapiro, GG | 1 |
| Bamman, J | 1 |
| Kanarek, P | 1 |
| Bierman, CW | 1 |
| Wood, DL | 1 |
| Martinez, R | 1 |
| Tecklin, JS | 1 |
| Holsclaw, DS | 1 |
| Adshead, PC | 1 |
| Mills, CL | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-Blind, Placebo-Controlled, Dose-finding Study to Evaluate the Efficacy and Safety of Aerosolized Moli1901 in Adolescents (12 Years of Age or Older) and Adults With Cystic Fibrosis[NCT00671736] | Phase 2 | 160 participants (Anticipated) | Interventional | 2007-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for isoproterenol and Cystic Fibrosis
| Article | Year |
|---|---|
Autoantibodies to beta 2-adrenergic receptors and allergic respiratory disease.
Topics: Animals; Antigen-Antibody Reactions; Asthma; Autoantibodies; Cattle; Cross Reactions; Cystic Fibrosi | 1982 |
Fluid transport by airway epithelia.
Topics: Animals; Biological Transport, Active; Cystic Fibrosis; Dogs; Epithelium; Humans; Isoproterenol; Met | 1987 |
7 trials available for isoproterenol and Cystic Fibrosis
| Article | Year |
|---|---|
A multicenter study of the effect of solution temperature on nasal potential difference measurements.
Topics: Adult; Amiloride; Bronchodilator Agents; Chloride Channels; Chlorides; Confidence Intervals; Cystic | 2003 |
A phase I trial of intranasal Moli1901 for cystic fibrosis.
Topics: Administration, Intranasal; Adolescent; Adult; Amiloride; Biological Transport; Chloride Channels; C | 2004 |
Hypertonic saline inhibits luminal sodium channels in respiratory epithelium.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Amiloride; Case-Control Studies; Cystic Fibrosis; Dose- | 2007 |
Reliable diagnosis of the major type of cystic fibrosis with fibroblast cultures. A double blind study.
Topics: Adolescent; Adult; Alkaline Phosphatase; Cells, Cultured; Child; Child, Preschool; Clinical Trials a | 1978 |
The paradoxical effect of adrenergic and methylxanthine drugs in cystic fibrosis.
Topics: Administration, Oral; Adolescent; Adult; Aerosols; Child; Clinical Trials as Topic; Cystic Fibrosis; | 1976 |
Bronchial drainage with aerosol medications in cystic fibrosis.
Topics: Acetylcysteine; Adolescent; Adult; Aerosols; Bronchi; Child; Cystic Fibrosis; Drainage; Drug Evaluat | 1976 |
Assessment of bronchospasm in patients with cystic fibrosis.
Topics: Adolescent; Adult; Aerosols; Bronchial Spasm; Child; Child, Preschool; Clinical Trials as Topic; Cys | 1969 |
124 other studies available for isoproterenol and Cystic Fibrosis
| Article | Year |
|---|---|
Needle-free iontophoresis-driven β-adrenergic sweat rate test.
Topics: Adrenergic Agents; Aminophylline; Ascorbic Acid; Child; Chlorides; Cystic Fibrosis; Cystic Fibrosis | 2022 |
Combined agonists act synergistically to increase mucociliary clearance in a cystic fibrosis airway model.
Topics: Animals; Carbachol; Colforsin; Cystic Fibrosis; Disease Models, Animal; Drug Synergism; Drug Therapy | 2021 |
Insights into the variability of nasal potential difference, a biomarker of CFTR activity.
Topics: Adult; Amiloride; Biological Transport; Bronchodilator Agents; Chlorides; Cystic Fibrosis; Cystic Fi | 2020 |
Contractile Properties of Intrapulmonary Airway Smooth Muscle in Cystic Fibrosis.
Topics: Adult; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Cystic Fibrosis; Cystic Fibrosis Tr | 2019 |
Nasal potential difference measurements in diagnosis of cystic fibrosis: an international survey.
Topics: Adrenergic beta-Agonists; Amiloride; Chlorides; Cystic Fibrosis; Diagnostic Techniques, Respiratory | 2014 |
In vivo readout of CFTR function: ratiometric measurement of CFTR-dependent secretion by individual, identifiable human sweat glands.
Topics: Adrenergic beta-Agonists; Adult; Aminophylline; Atropine; Cystic Fibrosis; Cystic Fibrosis Transmemb | 2013 |
Mucociliary clearance and submucosal gland secretion in the ex vivo ferret trachea.
Topics: Analgesics, Non-Narcotic; Angiogenesis Inhibitors; Animals; Bronchodilator Agents; Bumetanide; Calci | 2014 |
Nasal potential difference outcomes support diagnostic decisions in cystic fibrosis.
Topics: Adrenergic beta-Agonists; Adult; Amiloride; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductan | 2016 |
Sweat gland bioelectrics differ in cystic fibrosis: a new concept for potential diagnosis and assessment of CFTR function in cystic fibrosis.
Topics: Adrenergic beta-Agonists; Adult; Biomarkers; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembra | 2009 |
Exercise reduces airway sodium ion reabsorption in cystic fibrosis but not in exercise asthma.
Topics: Adult; Amiloride; Asthma, Exercise-Induced; Chloride Channels; Cystic Fibrosis; Exercise; Exercise T | 2011 |
Measurement of airway ion transport assists the diagnosis of cystic fibrosis.
Topics: Adolescent; Adult; Amiloride; Chlorides; Cohort Studies; Cystic Fibrosis; Epithelium; Female; Humans | 2010 |
Altered ion transport by thyroid epithelia from CFTR(-/-) pigs suggests mechanisms for hypothyroidism in cystic fibrosis.
Topics: Amiloride; Animals; Cells, Cultured; Chloride Channels; Chlorides; Cystic Fibrosis; Cystic Fibrosis | 2010 |
Cystic fibrosis and the relationship between mucin and chloride secretion by cultures of human airway gland mucous cells.
Topics: Adenosine Triphosphate; Adrenergic alpha-1 Receptor Agonists; Adrenergic beta-Agonists; Adult; Bronc | 2011 |
Ileal smooth muscle dysfunction and remodeling in cystic fibrosis.
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Blotting, Western; Cystic Fibrosis; Cystic Fibrosis Tr | 2012 |
Influence of perfusate temperature on nasal potential difference.
Topics: Adolescent; Adult; Amiloride; Chloride Channels; Chlorides; Cystic Fibrosis; Healthy Volunteers; Hum | 2013 |
Modified method to measure nasal potential difference.
Topics: Adolescent; Adult; Amiloride; Biological Transport, Active; Case-Control Studies; Child; Chlorides; | 2003 |
Disruptive effects of anion secretion inhibitors on airway mucus morphology in isolated perfused pig lung.
Topics: Adrenergic beta-Agonists; Algorithms; Amiloride; Animals; Anions; Bethanechol; Bicarbonates; Bronchi | 2003 |
Measurement of nasal potential difference in mild asthmatics.
Topics: Adolescent; Adult; Amiloride; Asthma; Cystic Fibrosis; Female; Humans; Ion Transport; Isoproterenol; | 2003 |
Airway surface liquid calcium modulates chloride permeability in the cystic fibrosis airway.
Topics: Adolescent; Adult; Amiloride; Bronchodilator Agents; Calcium; Calcium Signaling; Cations, Divalent; | 2003 |
BRONCHIECTASIS AND CHRONIC PULMONARY SUPPURATION.
Topics: Aerosols; Anti-Bacterial Agents; Bronchial Diseases; Bronchiectasis; Bronchodilator Agents; Child; C | 1964 |
A THERAPEUTIC REGIMEN FOR PATIENTS WITH CYSTIC FIBROSIS.
Topics: Adolescent; Anti-Bacterial Agents; Breathing Exercises; Child; Cystic Fibrosis; Escherichia coli Inf | 1964 |
Activation of airway cl- secretion in human subjects by adenosine.
Topics: Adenosine; Adolescent; Adrenergic beta-Agonists; Adult; Bronchi; Case-Control Studies; Cell Line; Ch | 2004 |
Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects.
Topics: Animals; Calcium; Calnexin; Cell Line; Cell Membrane; Cricetinae; Curcumin; Cystic Fibrosis; Cystic | 2004 |
Analysis of cystic fibrosis gener product (CFTR) function in patients with pancreas divisum and recurrent acute pancreatitis.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Chloride Channels; Cystic Fibrosis; Cystic Fibrosis T | 2004 |
Salivary secretion assay for drug efficacy for cystic fibrosis in mice.
Topics: Acetylcholine; Animals; Cystic Fibrosis; Disease Models, Animal; Drug Evaluation, Preclinical; Isopr | 2005 |
The effect of varying tonicity on nasal epithelial ion transport in cystic fibrosis.
Topics: Adult; Amiloride; Case-Control Studies; Culture Techniques; Cystic Fibrosis; Cystic Fibrosis Transme | 2005 |
The CF-CIRC study: a French collaborative study to assess the accuracy of cystic fibrosis diagnosis in neonatal screening.
Topics: Amiloride; Catheterization; Child, Preschool; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembr | 2006 |
Cystic fibrosis fibroblasts respond normally to isoproterenol.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adolescent; Adult; Cell | 1981 |
Abnormal adrenergic and cholinergic sensitivity in cystic fibrosis.
Topics: Adolescent; Adult; Autonomic Nervous System; Carbachol; Cystic Fibrosis; Female; Humans; Isoproteren | 1980 |
Enhanced adenosine 3':5' - monophosphate response to beta-adrenergic stimulation in cystic fibrosis fibroblasts after removal of conditioned medium.
Topics: Cells, Cultured; Culture Media; Cyclic AMP; Cystic Fibrosis; Fibroblasts; Humans; Infant; Isoprotere | 1980 |
Hormone-stimulated cyclic AMP production by skin fibroblasts cultured from healthy persons and patients with cystic fibrosis.
Topics: Adolescent; Adult; Cells, Cultured; Culture Media; Cyclic AMP; Cystic Fibrosis; Fibroblasts; Humans; | 1980 |
Changes in beta adrenergic receptors in submaxillary glands of chronically reserpine- or isoproterenol-treated rats.
Topics: Animals; Cystic Fibrosis; Disease Models, Animal; Feedback; Isoproterenol; Kinetics; Nucleotidases; | 1981 |
Beta adrenergic receptors in lymphocytes and granulocytes from patients with cystic fibrosis.
Topics: Adolescent; Adult; Cyclic AMP; Cystic Fibrosis; Dihydroalprenolol; Granulocytes; Heterozygote; Human | 1983 |
Defective beta adrenergic response of cystic fibrosis sweat glands in vivo and in vitro.
Topics: Atropine; Child; Cystic Fibrosis; Humans; Isoproterenol; Methacholine Chloride; Methacholine Compoun | 1984 |
Autonomic and airway reactivity in obligate heterozygotes for cystic fibrosis.
Topics: Adult; Autonomic Nervous System; Bronchi; Bronchial Provocation Tests; Carbachol; Cyclic AMP; Cystic | 1984 |
Pulmonary function of the reserpine and isoproterenol models of cystic fibrosis.
Topics: Airway Resistance; Animals; Cystic Fibrosis; Disease Models, Animal; Isoproterenol; Lung Volume Meas | 1984 |
Differing luminal potential difference of cystic fibrosis and control sweat secretory coils in vitro.
Topics: Adult; Cystic Fibrosis; Epithelium; Evoked Potentials; Humans; Isoproterenol; Male; Membrane Potenti | 1984 |
Effect of serum from normal and cystic fibrosis subjects on mucin secretion from dispersed rat submandibular cells.
Topics: Adolescent; Adult; Animals; Child; Cystic Fibrosis; Dose-Response Relationship, Drug; Humans; Isopro | 1983 |
The chronically isoproterenol-treated rat in the study of cystic fibrosis: X-ray microanalysis of the submandibular gland.
Topics: Animals; Calcium; Cystic Fibrosis; Disease Models, Animal; Drug Interactions; Electron Probe Microan | 1984 |
Isolated parotid acinar cells from DL-isoproterenol-treated rats. A cellular model for cystic fibrosis.
Topics: Animals; Cell Separation; Cell Survival; Cystic Fibrosis; Hypertrophy; Isoproterenol; Male; Models, | 1981 |
Gas exchange at rest and during exercise in adults with cystic fibrosis.
Topics: Adolescent; Adult; Arteries; Biomechanical Phenomena; Cystic Fibrosis; Female; Hemodynamics; Humans; | 1982 |
Analysis of granulocyte beta-adrenergic response in cystic fibrosis: correlation of decreased responsiveness with disease severity.
Topics: Adolescent; Airway Obstruction; Child; Cystic Fibrosis; Dose-Response Relationship, Drug; Female; Fo | 1981 |
Alkaline phosphatase activity of normal and cystic fibrosis fibroblasts.
Topics: Alkaline Phosphatase; Cells, Cultured; Child; Cystic Fibrosis; Female; Glycoproteins; Humans; Isopro | 1980 |
Composition of pulmonary lavage fluid in control and reserpine-treated rats following chronic isoproterenol and pilocarpine administration.
Topics: Animals; Body Fluids; Carbohydrates; Cystic Fibrosis; Disease Models, Animal; Isoproterenol; Lipids; | 1980 |
Actions of isoprenaline on amylase and total protein content of whole saliva in control, cystic fibrosis and cystic fibrosis heterozygote individuals.
Topics: Adolescent; Adult; Amylases; Child; Cystic Fibrosis; Heterozygote; Humans; Isoproterenol; Proteins; | 1994 |
Effects of mutations in cAMP-dependent protein kinase on chloride efflux in Caco-2 human colonic carcinoma cells.
Topics: Carbachol; Chloride Channels; Colforsin; Colonic Neoplasms; Cyclic AMP; Cyclic AMP-Dependent Protein | 1995 |
ATPo but not cAMPi activates a chloride conductance in mouse ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Triphosphate; Animals; Cells, Cultured; Chloride C | 1995 |
In vivo nasal potential difference: techniques and protocols for assessing efficacy of gene transfer in cystic fibrosis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amiloride; Biological Transport; Calcium; Child; Child, | 1995 |
Functional expression of adrenergic and opioid receptors in Xenopus oocytes: interaction between alpha 2- and beta 2-adrenergic receptors.
Topics: Adenylyl Cyclases; Animals; Brimonidine Tartrate; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; | 1995 |
The genetic advantage hypothesis in cystic fibrosis heterozygotes: a murine study.
Topics: Animals; Bacterial Toxins; Calcium; Carbachol; Chloride Channels; Cholera Toxin; Colforsin; Colon; C | 1995 |
Protocols for in vivo measurement of the ion transport defects in cystic fibrosis nasal epithelium.
Topics: Adult; Amiloride; Biological Transport, Active; Chlorides; Cystic Fibrosis; Electric Conductivity; F | 1994 |
The role of protein kinase C in alpha-adrenergic regulation of NaCl(K) cotransport in human airway epithelial cells.
Topics: Alkaloids; Arachidonic Acid; Carrier Proteins; Chlorides; Cystic Fibrosis; Diglycerides; Epinephrine | 1995 |
Increased ion transport in cultured nasal polyp epithelial cells.
Topics: Absorption; Adenosine Triphosphate; Amiloride; Cell Membrane Permeability; Cells, Cultured; Chloride | 1994 |
In vitro bioelectric properties of bronchial epithelium from transplanted lungs in recipients with cystic fibrosis.
Topics: Adolescent; Adult; Amiloride; Biopsy; Bronchi; Child; Cystic Fibrosis; Electrophysiology; Epithelium | 1993 |
Dual mechanisms for Na-K-Cl cotransport regulation in airway epithelial cells.
Topics: Adenosine Triphosphate; Animals; Bumetanide; Carrier Proteins; Cells, Cultured; Cystic Fibrosis; Dog | 1993 |
Activation of endogenous deltaF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Albuterol; Base Sequence; Calcium; Cell Line; | 1996 |
Alpha 1-adrenergic stimulation differentially regulates ether-linked diacylglycerols in airway epithelial cells from normal and cystic fibrosis patients.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A | 1996 |
Relationship between airway ion transport and a mild pulmonary disease mutation in CFTR.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Amiloride; Animals; Child; Chlorides; COS Cells; Cyclic | 1997 |
Correlation between nasal potential difference measurements, genotype and clinical condition in patients with cystic fibrosis.
Topics: Adult; Amiloride; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; F | 1997 |
Pseudomonas aeruginosa lipopolysaccharide induces CF-like alteration of protein secretion by human tracheal gland cells.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Carbachol; Cells, Cultured; Cholinergic Agonists; | 1997 |
Nasal potential difference in congenital bilateral absence of the vas deferens.
Topics: Adrenergic beta-Agonists; Adult; Amiloride; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembran | 1998 |
The in vivo effects of milrinone on the airways of cystic fibrosis mice and human subjects.
Topics: Amiloride; Animals; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; | 1999 |
Respiratory epithelial ion transport in patients with disseminated bronchiectasis.
Topics: Adolescent; Adult; Amiloride; Bronchiectasis; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conduct | 1999 |
Pulmonary disease severity in men with deltaF508 cystic fibrosis and residual chloride secretion.
Topics: Adenosine Triphosphate; Adult; Amiloride; Bronchodilator Agents; Chloride Channels; Chlorides; Cysti | 1999 |
Stimulation of Cl(-) secretion by chlorzoxazone.
Topics: Amiloride; Anions; Bronchi; Bumetanide; Cell Membrane; Cells, Cultured; Charybdotoxin; Chlorine; Chl | 2000 |
A simplified cyclic adenosine monophosphate-mediated sweat rate test for quantitative measure of cystic fibrosis transmembrane regulator (CFTR) function.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aminophylline; Atropine; Child; Cyclic AMP; Cystic Fibr | 2000 |
The CFTR-mediated protein secretion defect: pharmacological correction.
Topics: Adrenergic beta-Agonists; Animals; Cell Line; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmemb | 2001 |
Calcium-pump inhibitors induce functional surface expression of Delta F508-CFTR protein in cystic fibrosis epithelial cells.
Topics: Amiloride; Calcium Channel Blockers; Cell Membrane; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosi | 2002 |
Relevance of second messengers in cystic fibrosis.
Topics: Adrenergic beta-Antagonists; Cyclic AMP; Cystic Fibrosis; Fibroblasts; Humans; Isoproterenol; Neurot | 1979 |
The chronically reserpinized rat as a possible model for cystic fibrosis. I. Submaxillary gland morphology and ultrastructure.
Topics: Animals; Body Weight; Cell Nucleus; Cystic Fibrosis; Cytoplasm; Disease Models, Animal; Endoplasmic | 1975 |
Abnormal levels of 3':5'-cyclic AMP in isoproterenol-stimulated fibroblasts from patients with cystic fibrosis.
Topics: Age Factors; Cell Division; Cells, Cultured; Cyclic AMP; Cystic Fibrosis; Dose-Response Relationship | 1976 |
Decreased adenosine 3':5'-monophosphate response to isoproterenol in cystic fibrosis leukocytes.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Cyclic AMP; Cystic Fibrosis; Digoxin; Female; Granulocytes | 1978 |
Pleiotropic drug resistance in cystic fibrosis fibroblasts: increased resistance to cyclic AMP.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Bucladesine; Cell Line; Cell Survival; Cystic Fibrosis; Drug Re | 1978 |
A comparative study of inhaled atropine sulfate and isoproterenol hydrochloride in cystic fibrosis.
Topics: Adolescent; Aerosols; Airway Resistance; Atropine; Child; Cystic Fibrosis; Dose-Response Relationshi | 1979 |
The chronically reserpinized rat as an animal model for cystic fibrosis: I. Acute effect of isoproterenol and pilocarpine upon pulmonary lavage fluid.
Topics: Animals; Carbohydrate Metabolism; Cholesterol; Cystic Fibrosis; Isoproterenol; Lipid Metabolism; Lun | 1979 |
Cystic fibrosis: potential management through manipulation of the secretory process in affected exocrine glands.
Topics: Animals; Cats; Cystic Fibrosis; Exocrine Glands; Ferrets; Isoproterenol; Macromolecular Substances; | 1979 |
Reliable detection of cystic fibrosis in skin-derived fibroblast cultures.
Topics: Alkaline Phosphatase; Cells, Cultured; Cystic Fibrosis; Enzyme Induction; Female; Fibroblasts; Glyco | 1978 |
The chronically reserpinized rat as a possible model for cystic fibrosis. VI. Synergistic effects of isoproterenol on Ca++ and protein in the submaxillary gland.
Topics: Animals; Calcium; Cystic Fibrosis; Disease Models, Animal; Drug Synergism; Isoproterenol; Male; Prot | 1977 |
The chronically reserpinized rat as a possible model for cystic fibrosis. II. Comparison and cilioinhibitory effects of submaxillary saliva.
Topics: Animals; Biological Assay; Bivalvia; Calcium; Carbohydrates; Cilia; Cystic Fibrosis; Disease Models, | 1975 |
An antibody against a CFTR-derived synthetic peptide, incorporated into living submandibular cells, inhibits beta-adrenergic stimulation of mucin secretion.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Antibodies; | 1992 |
The kallikrein-kinin system of sweat in normal and cystic fibrosis subjects.
Topics: Child; Cystic Fibrosis; Female; Humans; Isoproterenol; Kallikreins; Male; Pilocarpine; Prekallikrein | 1992 |
Bioelectric properties of cystic fibrosis airways obtained at heart-lung transplantation.
Topics: Amiloride; Bronchi; Cystic Fibrosis; Heart-Lung Transplantation; Humans; Ion Transport; Isoprotereno | 1992 |
Functional insertion of the SV40 large T oncogene in cystic fibrosis intestinal epithelium. Characterization of CFI-3 cells.
Topics: Antigens, Polyomavirus Transforming; Base Sequence; Cell Line; Cell Transformation, Viral; Chloride | 1991 |
Roles of Ca and cAMP on C1 channel activity in cystic fibrosis sweat clear cells as studied by microsuperfusion and cell volume analysis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Chloride Channels; Chlorides; Cyclic AMP; Cystic Fibr | 1991 |
Altered biochemical regulation of secretion in cystic fibrosis epithelial cells.
Topics: Adolescent; Adult; Calcium; Calmodulin-Binding Proteins; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosi | 1991 |
X-ray microanalysis of cAMP-induced ion transport in cystic fibrosis fibroblasts.
Topics: Cells, Cultured; Chlorine; Cyclic AMP; Cystic Fibrosis; Electron Probe Microanalysis; Fibroblasts; H | 1991 |
Chloride ion transport in transformed normal and cystic fibrosis epithelial cells.
Topics: Biological Transport, Active; Cell Line, Transformed; Chlorides; Cystic Fibrosis; Epinephrine; Epith | 1991 |
Further evidence for abnormal protein kinase C regulation of macromolecule secretion in fibroblasts from cystic fibrosis patients.
Topics: Binding Sites; Bucladesine; Calcimycin; Cells, Cultured; Colforsin; Cystic Fibrosis; Dose-Response R | 1990 |
Dissociation between cyclic AMP rise and mucin secretion in response to a beta-adrenergic agonist.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic AMP; Cystic Fibrosis; Humans; In Vitro Techniqu | 1990 |
The response of chloride transport to cyclic AMP, calcium and hypotonic shock in normal and cystic fibrosis fibroblasts.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Bucladesine; Calcimycin; Calcium; Cell Line; Cells, Cultured | 1990 |
Longitudinal response of pulmonary function to bronchodilators in cystic fibrosis.
Topics: Aerosols; Bronchodilator Agents; Cross-Sectional Studies; Cystic Fibrosis; Female; Forced Expiratory | 1990 |
Adrenergic secretory responses of submandibular tissues from control subjects and cystic fibrosis patients.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Amylases; Child; Cyclic AMP; Cystic Fibrosis; Dose-Response Rela | 1985 |
An apical-membrane chloride channel in human tracheal epithelium.
Topics: Anthracenes; Cell Membrane; Chlorides; Cystic Fibrosis; Epithelium; Ion Channels; Isoproterenol; Tra | 1986 |
Defective beta-adrenergic secretory responses in submandibular acinar cells from cystic fibrosis patients.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Amylases; Cells, Cultured; Child; Cystic Fibrosis; Humans; Infan | 1986 |
Activation of an apical Cl- conductance by Ca2+ ionophores in cystic fibrosis airway epithelia.
Topics: Adolescent; Adult; Amiloride; Calcimycin; Calcium; Cells, Cultured; Chloride Channels; Chlorides; Cy | 1989 |
Chloride secretory response of cystic fibrosis human airway epithelia. Preservation of calcium but not protein kinase C- and A-dependent mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Amiloride; Bradykinin; Calcimycin; Calcium; Child; C | 1989 |
Heterozygotes for cystic fibrosis: models for study of airway and autonomic reactivity.
Topics: Adult; Aged; Autonomic Nervous System; Carbachol; Cold Temperature; Cyclic AMP; Cystic Fibrosis; Gen | 1989 |
Alpha-adrenergic regulation of Na-Cl cotransport in human airway epithelium.
Topics: Carrier Proteins; Chlorides; Cystic Fibrosis; Epinephrine; Epithelium; Furosemide; Humans; Intracell | 1989 |
Cell calcium levels of normal and cystic fibrosis nasal epithelium.
Topics: Adolescent; Adult; Aged; Aminoquinolines; Benzofurans; Calcium; Cells, Cultured; Child; Cyclic AMP; | 1988 |
Persistence of abnormal chloride ion permeability in cystic fibrosis nasal epithelial cells in heterologous culture.
Topics: Adolescent; Adult; Aged; Amiloride; Animals; Cell Membrane Permeability; Cells, Cultured; Child; Chl | 1985 |
X-ray microanalysis of exocrine glands in animal models for cystic fibrosis.
Topics: Adrenergic beta-Agonists; Animals; Cystic Fibrosis; Cytoplasmic Granules; Disease Models, Animal; El | 1985 |
Variable reduction in beta-adrenergic sweat secretion in cystic fibrosis heterozygotes.
Topics: Acclimatization; Adrenergic beta-Agonists; Adult; Cystic Fibrosis; Dose-Response Relationship, Drug; | 1988 |
Responsiveness of superficial hand veins to adrenergic stimuli in patients with cystic fibrosis.
Topics: Adult; Cystic Fibrosis; Dose-Response Relationship, Drug; Hand; Humans; Isoproterenol; Male; Muscle, | 1989 |
HLA-B18 is associated with decreased levels of isoproterenol-stimulated cAMP in lymphocytes.
Topics: Adolescent; Adult; Child; Child, Preschool; Cleft Palate; Cyclic AMP; Cystic Fibrosis; Female; Gene | 1985 |
Conditioned media from cultured cystic fibrosis fibroblasts inhibits Na/K ATPase activity.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; Cell-Free System; Culture Media; Cyclic AMP; C | 1985 |
Cystic fibrosis and beta-adrenergic response of airway epithelial cell cultures.
Topics: Cells, Cultured; Cyclic AMP; Cystic Fibrosis; Electrophysiology; Epithelial Cells; Epithelium; Isopr | 1986 |
Lymphocyte and granulocyte phosphatidylethanolamine N-methyltransferase: properties and activity in cystic fibrosis.
Topics: Adolescent; Adult; Cell Membrane; Cyclic AMP; Cystic Fibrosis; Female; Granulocytes; Humans; Isoprot | 1986 |
Changes in glycoconjugates in rat submandibular gland after chronic treatment with reserpine and isoproterenol.
Topics: Animals; Cystic Fibrosis; Cytoplasmic Granules; Disease Models, Animal; Glycoconjugates; Isoproteren | 1988 |
Evidence for reduced Cl- and increased Na+ permeability in cystic fibrosis human primary cell cultures.
Topics: Adolescent; Adult; Amiloride; Biological Transport, Active; Cell Membrane Permeability; Cells, Cultu | 1988 |
Effects of chronic furosemide treatment on rat exocrine glands.
Topics: Animals; Biological Transport; Cations; Chlorides; Cystic Fibrosis; Disease Models, Animal; Exocrine | 1988 |
Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation.
Topics: Adenylyl Cyclases; Adolescent; Adult; Child; Cystic Fibrosis; Enzyme Activation; Epithelium; Female; | 1986 |
Abnormal apical cell membrane in cystic fibrosis respiratory epithelium. An in vitro electrophysiologic analysis.
Topics: Amiloride; Cell Membrane; Cell Membrane Permeability; Chlorides; Cystic Fibrosis; Epithelium; Humans | 1987 |
Cystic fibrosis decreases the apical membrane chloride permeability of monolayers cultured from cells of tracheal epithelium.
Topics: Animals; Cell Membrane Permeability; Cells, Cultured; Child; Chlorides; Cystic Fibrosis; Dogs; Elect | 1985 |
Immunologic release of chemical mediators from human nasal polyps.
Topics: Allergens; Anaphylaxis; Butyrates; Carbachol; Chemotaxis; Cholera; Cyclic AMP; Cystic Fibrosis; Depr | 1973 |
Hyperpermeable mucus in cystic fibrosis.
Topics: Animals; Biological Transport, Active; Calcium; Cell Membrane Permeability; Cystic Fibrosis; Dialysi | 1970 |
Coexistent respiratory allergy and cystic fibrosis.
Topics: Adolescent; Adult; Airway Obstruction; Asthma; California; Child; Child, Preschool; Cystic Fibrosis; | 1974 |
Inhalation therapy and postural drainage for the treatment of cystic fibrosis.
Topics: Acetylcysteine; Aerosols; Cystic Fibrosis; Drainage; Humans; Isoproterenol; Methicillin; Neomycin; O | 1967 |
The effect of a nebulized bronchodilator administered with or without intermittent positive pressure breathing on ventilatory function in children with cystic fibrosis and asthma.
Topics: Adult; Aerosols; Airway Obstruction; Airway Resistance; Asthma; Child; Cystic Fibrosis; Humans; Isop | 1972 |
The effect of isoprenaline and pilocarpine on (a) bronchial mucus-secreting tissue and (b) pancreas, salivary glands, heart, thymus, liver and spleen.
Topics: Animals; Bronchi; Cystic Fibrosis; Glycoproteins; Heart; Isoproterenol; Liver; Mucous Membrane; Mucu | 1973 |
The effect of isoproterenol on airway obstruction in cystic fibrosis.
Topics: Adolescent; Adult; Airway Resistance; Child; Cystic Fibrosis; Female; Humans; Isoproterenol; Lung; M | 1970 |
Pulmonary mechanics in asthma and cystic fibrosis.
Topics: Adolescent; Airway Obstruction; Asthma; Child; Cystic Fibrosis; Female; Glycols; Humans; Isoproteren | 1971 |
Use of pulmonary function tests in asthma and cystic fibrosis.
Topics: Adolescent; Adult; Asthma; Blood Gas Analysis; Child; Cystic Fibrosis; Humans; Isoproterenol; Plethy | 1971 |
The effect of adrenergic stimulation upon sweating in normal children and cystic fibrosis patients.
Topics: Adolescent; Adult; Atropine; Child; Child, Preschool; Cystic Fibrosis; Epinephrine; Humans; Iontopho | 1968 |
Simple tests of ventilatory capacity in children with cystic fibrosis. I. Clinical and radiological findings in 85 patients. II. Three-year follow-up on 50 patients.
Topics: Adolescent; Body Height; Child; Child, Preschool; Cystic Fibrosis; Female; Follow-Up Studies; Humans | 1968 |