Compounds > isoproterenol
Page last updated: 2024-10-29

isoproterenol and Cardiomyopathies

isoproterenol has been researched along with Cardiomyopathies in 340 studies

Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.

Cardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).

Research Excerpts

ExcerptRelevanceReference
" However, its effects on isoproterenol-induced myocardial fibrosis in mice remain unknown."8.12Apigenin inhibits isoproterenol-induced myocardial fibrosis and Smad pathway in mice by regulating oxidative stress and miR-122-5p/155-5p expressions. ( Li, C; Niu, G; Sun, K; Wang, F; Weng, J; Xie, M; Zhang, J; Zhang, Q, 2022)
"This study aimed to investigate the anti-fibrotic effects of ghrelin in isoproterenol (ISO)-induced myocardial fibrosis and the underlying mechanism."7.96Chronic peripheral ghrelin injection exerts antifibrotic effects by increasing growth differentiation factor 15 in rat hearts with myocardial fibrosis induced by isoproterenol. ( Feng, L; Lin, P; Ren, Q; Wang, Q; Zhang, B, 2020)
"Isoproterenol (ISO) induced oxidative stress and inflammation is involved in the pathogenesis of myocardial necrosis."7.96Erdosteine salvages cardiac necrosis: Novel effect through modulation of MAPK and Nrf-2/HO-1 pathway. ( Arya, DS; Bhatia, J; Malik, S; Mutneja, E; Ray, R; Sahu, AK; Verma, VK, 2020)
"Stevioside, a natural glycoside compound, has many beneficial biological activities, but its protective effect on myocardial fibrosis has not been reported yet."7.91Stevioside attenuates isoproterenol-induced mouse myocardial fibrosis through inhibition of the myocardial NF-κB/TGF-β1/Smad signaling pathway. ( Jia, CH; Shen, W; Wang, J; Xie, ML; Zhang, JY, 2019)
"We hypothesized that Chikusetsusaponin IVa (CS), a major component of Saponins from Panaxjaponicus, may improve isoprenaline induced myocardial fibrosis via AMPK/mTOR/ULK1 mediated autophagy METHODS: Continuous subcutaneous injection of isoproterenol for 21 days was used to induce myocardial fibrosis in mice and high and low doses (15 mg/kg and 5 mg/kg) of CS was administered by oral gavage to observe the efficacy."7.91Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling. ( He, Y; Liu, C; Liu, X; Wang, J; Wang, L; Wang, T; Wu, X; Yuan, D; Zhang, C; Zheng, J; Zhou, Z, 2019)
"We previously reported a genetic analysis of heart failure traits in a population of inbred mouse strains treated with isoproterenol to mimic catecholamine-driven cardiac hypertrophy."7.85Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice. ( Karma, A; Lusis, AJ; Rau, CD; Ren, S; Romay, MC; Santolini, M; Tuteryan, M; Wang, JJ; Wang, Y; Weiss, JN, 2017)
" The present study was intended to appraise the nutraceutical inherent of HPLC standardized Spinacia oleracea methanolic leaf extract (SoLE) in isoproterenol (ISO) induced male albino Wistar rats via activation of pro-inflammatory signaling pathway that drives myocardial necrosis."7.85Nutraceutical inherent of Spinacia oleracea Linn. methanolic leaf extract ameliorates isoproterenol induced myocardial necrosis in male albino Wistar rats via mitigating inflammation. ( Jolapuram, U; Kodidhela, LD; Vutharadhi, S, 2017)
"Isoproterenol infusions generated significant cardiac fibrosis (p < 0."7.83Paricalcitol Attenuates Cardiac Fibrosis and Expression of Endothelial Cell Transition Markers in Isoproterenol-Induced Cardiomyopathic Rats. ( Cheng, PW; Hsiao, M; Lai, CC; Liou, JC; Liu, CP; Lu, PJ; Lu, WH; Sun, GC; Tseng, CJ, 2016)
"Combined effects of vincristine and quercetin in the regulation of isoproterenol (ISO)-induced cardiac necrosis have been evaluated in rats."7.81Combined Effects of Vincristine and Quercetin in Reducing Isoproterenol-Induced Cardiac Necrosis in Rats. ( Kar, A; Panda, S, 2015)
"Although it is well known that isoproterenol (ISO) causes myocardial hypertrophy and myocardial fibrosis in rats, it has remained elusive whether heat shock factor 1 (HSF1) has a role in this process."7.81Roles of heat shock factor 1 in isoproterenol‑induced myocardial fibrosis in mice. ( Fang, L; Xie, Y; Zhang, B; Zhang, L, 2015)
"Our study concluded that ritonavir, a nonspecific GLUT inhibitors showed complete protection in catecholamine induced myocardial necrosis."7.79Cardioprotective effect of ritonavir, an antiviral drug, in isoproterenol induced myocardial necrosis: a new therapeutic implication. ( Banerjee, SK; Bulani, Y; Gupta, P; Kanwal, A; Khatua, TN; Kuncha, M; Putcha, UK; Sojitra, B, 2013)
"To explore the effects of Sini Decoction (SD) on the expressions of Samd2 and Smad7 isoproterenol (Iso) induced myocardial fibrosis rats."7.78[Effects of Sini decoction on the expressions of Smad2 and Smad7 in isoproterenol induced myocardial fibrosis rats]. ( Liao, HC; Liu, Y; Zhou, B, 2012)
"This study demonstrates that isoproterenol-induced myocardial necrosis resulted in progressive hemodynamic dysfunction of the left ventricle which most closely correlated with alterations in LV geometry."7.70Effect of left ventricular sphericity on the evolution of ventricular dysfunction in rats with diffuse isoproterenol-induced myocardial necrosis. ( Pfeffer, JM; Pfeffer, MA; Teerlink, JR, 1998)
"The present study was undertaken to compare the cardiomyopathies induced by experimental diabetes mellitus and chronic isoproterenol (ISO) pretreatment on inotropic reactivity of right ventricular strips from rats."7.68Pharmacological study of isoproterenol and diabetic cardiomyopathies in rat right ventricular strips. ( Gunasekaran, S; Tenner, TE; Young, JA, 1993)
"A study was designed to determine whether phenytoin (PHE) prevents the myocardial necrosis and subsequent fibrosis produced by isoproterenol (ISO)."7.68Influence of phenytoin on isoproterenol-induced myocardial fibrosis in rats. ( Besbasi, FS; Hamlin, RL, 1990)
"Administration of a single high dose or multiple low doses of isoproterenol (ISO) to rats induces myocardial necrosis and cardiac hypertrophy."7.67Quantification of myocardial necrosis and cardiac hypertrophy in isoproterenol-treated rats. ( Brinkman, CJ; Knufman, NM; van der Laarse, A; Vliegen, HW, 1987)
"Isoproterenol-induced myocardial necrosis was examined in male mice with alloxan-induced and genetically transmitted diabetes."7.67Influence of the diabetic state on isoproterenol-induced cardiac necrosis. ( el-Hage, AN; Ferrans, VJ; Herman, EH; Jordan, AW, 1985)
"The new calcium antagonist anipamil (1,7-bis-(3-methoxyphenyl)-3-methylaza-7-cyano-nonadecane) exhibited a pronounced protective effect against isoprenaline-induced myocardial necrosis in rats."7.67Protective effect of the new calcium antagonist anipamil against isoprenaline-induced cardionecrosis in rats. ( Ciplea, AG; Heimann, W; Kirchengast, M; Kretzschmar, R; Safer, A, 1988)
"The changes in myocardial copper were studied over a period of five days after producing myocardial necrosis in albino rats by subcutaneous injection of isoproterenol."7.66A temporal profile of changes in myocardial copper after isoproterenol induced cardiac necrosis. ( Ahmad, M; Jamil, SA; Kumar, S; Mahdi, SQ; Mathew, BM; Seth, TD, 1978)
"Trapidil increases the isoprenalin-induced necrosis of the myocardium in the rat."7.65[Modification of the isoprenaline-induced myocardial necrosis using trapidil]. ( Lampe, D; Lange, B; Mai, I, 1976)
" This is true for systemic hypoxia, hemorrhagic shock, and isoproterenol infusion."7.65Transmural metabolic gradients of the canine left ventricle in coronary constriction, systemic hypoxia, hemorrhagic shock, and isoproterenol infusion. ( Leunissen, RL, 1975)
"Heart failure (HF), caused by stress cardiomyopathy, is a major cause of mortality."5.91Sodium houttuyfonate against cardiac fibrosis attenuates isoproterenol-induced heart failure by binding to MMP2 and p38. ( Adu-Amankwaah, J; An, K; Cui, J; Lin, L; Song, N; Sun, H; Tan, R; Wang, M; You, Q; Yuan, J, 2023)
"Crocin has a protective effect on ISO-induced MF, which may be associated with the TLR4/NF-κB (p65) signal transduction pathway."5.56Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis. ( Cheng, J; Chu, L; Chu, X; Guan, S; Han, X; Jin, W; Li, Z; Ma, Z; Sun, S; Xue, Y; Zhang, X; Zhang, Y, 2020)
"Fibrosis was induced by ISO administration (5 mg/kg/d subcutaneously) for 10 days."5.51Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats. ( Che, Y; Jin, YG; Shen, DF; Wang, SS; Wang, ZP; Wu, QQ; Yuan, Y, 2019)
"However, its potential effect on cardiac hypertrophy remains unclear."5.51Chrysophanol attenuated isoproterenol-induced cardiac hypertrophy by inhibiting Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway. ( Bi, X; Hong, H; Lu, J; Wang, J; Ye, J; Yu, Y; Yuan, J; Zhang, Y, 2019)
"Isoproterenol (ISO) has been widely used to establish cardiac injury in vivo and in vitro."5.46Shikonin ameliorates isoproterenol (ISO)-induced myocardial damage through suppressing fibrosis, inflammation, apoptosis and ER stress. ( Chen, DL; Wang, Z; Yang, J, 2017)
"Propranolol pretreatment decreased the accumulation of radioactivity in a dose-dependent fashion."5.26Quantitation of isoproterenol-induced myocardial necrosis with 3H-tetracycline. ( Athari-Nejad, A; Holcslaw, TL; Ryan, CF, 1979)
"This study aims to shed light on aconite's potential as an anti-fibrotic agent and elucidate its mechanisms in a rat model of isoproterenol (ISO)-induced cardiac fibrosis."4.84Understanding aconite's anti-fibrotic effects in cardiac fibrosis. ( Feng, Y; He, J; Li, D; Peng, C; Xing, Z; Yang, C, 2024)
" These studies disclosed the unique nature of isoproterenol in producing 'infarct-like' myocardial necrosis."4.77Catecholamine cardiotoxicity. ( Rona, G, 1985)
" However, its effects on isoproterenol-induced myocardial fibrosis in mice remain unknown."4.12Apigenin inhibits isoproterenol-induced myocardial fibrosis and Smad pathway in mice by regulating oxidative stress and miR-122-5p/155-5p expressions. ( Li, C; Niu, G; Sun, K; Wang, F; Weng, J; Xie, M; Zhang, J; Zhang, Q, 2022)
"This study aimed to investigate the anti-fibrotic effects of ghrelin in isoproterenol (ISO)-induced myocardial fibrosis and the underlying mechanism."3.96Chronic peripheral ghrelin injection exerts antifibrotic effects by increasing growth differentiation factor 15 in rat hearts with myocardial fibrosis induced by isoproterenol. ( Feng, L; Lin, P; Ren, Q; Wang, Q; Zhang, B, 2020)
" Doxorubicin (DOX) and Isoproterenol (ISO) induced cardiotoxicity in wistar albino rats."3.96Investigation on protective effect of Terminalia bellirica (Roxb.) against drugs induced cardiotoxicity in wistar albino rats. ( Chaudhary, R; Kumar S, S; Kumar, N; Kumar, P; Singh, L; Singh, R; Verma, R, 2020)
"Isoproterenol (ISO) induced oxidative stress and inflammation is involved in the pathogenesis of myocardial necrosis."3.96Erdosteine salvages cardiac necrosis: Novel effect through modulation of MAPK and Nrf-2/HO-1 pathway. ( Arya, DS; Bhatia, J; Malik, S; Mutneja, E; Ray, R; Sahu, AK; Verma, VK, 2020)
"Stevioside, a natural glycoside compound, has many beneficial biological activities, but its protective effect on myocardial fibrosis has not been reported yet."3.91Stevioside attenuates isoproterenol-induced mouse myocardial fibrosis through inhibition of the myocardial NF-κB/TGF-β1/Smad signaling pathway. ( Jia, CH; Shen, W; Wang, J; Xie, ML; Zhang, JY, 2019)
"We hypothesized that Chikusetsusaponin IVa (CS), a major component of Saponins from Panaxjaponicus, may improve isoprenaline induced myocardial fibrosis via AMPK/mTOR/ULK1 mediated autophagy METHODS: Continuous subcutaneous injection of isoproterenol for 21 days was used to induce myocardial fibrosis in mice and high and low doses (15 mg/kg and 5 mg/kg) of CS was administered by oral gavage to observe the efficacy."3.91Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling. ( He, Y; Liu, C; Liu, X; Wang, J; Wang, L; Wang, T; Wu, X; Yuan, D; Zhang, C; Zheng, J; Zhou, Z, 2019)
"We previously reported a genetic analysis of heart failure traits in a population of inbred mouse strains treated with isoproterenol to mimic catecholamine-driven cardiac hypertrophy."3.85Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice. ( Karma, A; Lusis, AJ; Rau, CD; Ren, S; Romay, MC; Santolini, M; Tuteryan, M; Wang, JJ; Wang, Y; Weiss, JN, 2017)
" The present study was intended to appraise the nutraceutical inherent of HPLC standardized Spinacia oleracea methanolic leaf extract (SoLE) in isoproterenol (ISO) induced male albino Wistar rats via activation of pro-inflammatory signaling pathway that drives myocardial necrosis."3.85Nutraceutical inherent of Spinacia oleracea Linn. methanolic leaf extract ameliorates isoproterenol induced myocardial necrosis in male albino Wistar rats via mitigating inflammation. ( Jolapuram, U; Kodidhela, LD; Vutharadhi, S, 2017)
" The β-AR agonist isoproterenol (Iso) induced heart failure with high mortality in postpartum female, in non-pregnant female and in male CKO, but not in wild-type mice."3.85Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum cardiomyopathy. ( Bauersachs, J; Bengel, FM; Bogeski, I; Erschow, S; Haghikia, A; Hagl, C; Hilfiker-Kleiner, D; Jauhiainen, M; Kappl, R; Knuuti, J; Kohlhaas, M; Maack, C; Müller, M; Nickel, AG; Pietzsch, S; Ricke-Hoch, M; Roivainen, A; Saar, JA; Saraste, A; Scherr, M; Sieve, I; Silvola, JM; Stapel, B; Thackeray, JT; Tudorache, I, 2017)
"Isoproterenol infusions generated significant cardiac fibrosis (p < 0."3.83Paricalcitol Attenuates Cardiac Fibrosis and Expression of Endothelial Cell Transition Markers in Isoproterenol-Induced Cardiomyopathic Rats. ( Cheng, PW; Hsiao, M; Lai, CC; Liou, JC; Liu, CP; Lu, PJ; Lu, WH; Sun, GC; Tseng, CJ, 2016)
"Combined effects of vincristine and quercetin in the regulation of isoproterenol (ISO)-induced cardiac necrosis have been evaluated in rats."3.81Combined Effects of Vincristine and Quercetin in Reducing Isoproterenol-Induced Cardiac Necrosis in Rats. ( Kar, A; Panda, S, 2015)
" Cardiomyopathy results from cardiac injury, is the leading cause of heart failure, and can be induced in heart failure-prone rats through sub-chronic infusion of isoproterenol (ISO)."3.81Cardiomyopathy confers susceptibility to particulate matter-induced oxidative stress, vagal dominance, arrhythmia and pulmonary inflammation in heart failure-prone rats. ( Carll, AP; Cascio, WE; Costa, DL; Farraj, AK; Haykal-Coates, N; Hazari, MS; Ledbetter, AD; Richards, JH; Winsett, DW, 2015)
"Although it is well known that isoproterenol (ISO) causes myocardial hypertrophy and myocardial fibrosis in rats, it has remained elusive whether heat shock factor 1 (HSF1) has a role in this process."3.81Roles of heat shock factor 1 in isoproterenol‑induced myocardial fibrosis in mice. ( Fang, L; Xie, Y; Zhang, B; Zhang, L, 2015)
"Isoproterenol (5 mg·kg(-1)·d(-1)) was used to establish the cardiac fibrosis model in rats, which were administered RLX."3.81Relaxin inhibits cardiac fibrosis and endothelial-mesenchymal transition via the Notch pathway. ( Cai, JJ; Chen, LZ; Chen, X; Gao, Z; Gong, YS; Huang, WJ; Wang, LX; Zhang, HQ; Zhou, H; Zhou, X, 2015)
"Our study concluded that ritonavir, a nonspecific GLUT inhibitors showed complete protection in catecholamine induced myocardial necrosis."3.79Cardioprotective effect of ritonavir, an antiviral drug, in isoproterenol induced myocardial necrosis: a new therapeutic implication. ( Banerjee, SK; Bulani, Y; Gupta, P; Kanwal, A; Khatua, TN; Kuncha, M; Putcha, UK; Sojitra, B, 2013)
"To explore the effects of Sini Decoction (SD) on the expressions of Samd2 and Smad7 isoproterenol (Iso) induced myocardial fibrosis rats."3.78[Effects of Sini decoction on the expressions of Smad2 and Smad7 in isoproterenol induced myocardial fibrosis rats]. ( Liao, HC; Liu, Y; Zhou, B, 2012)
" Isoproterenol (ISO) infusion can accelerate cardiomyopathy in young SHHFs, while dietary salt loading in hypertensive rats induces cardiac fibrosis, hypertrophy, and--in a minority-congestive HF."3.77Dietary salt exacerbates isoproterenol-induced cardiomyopathy in rats. ( Carll, AP; Costa, DL; Farraj, AK; Haykal-Coates, N; Hazari, MS; Nyska, A; Richards, JH; Willis, MS; Winsett, DW, 2011)
" Similarly, adult beta1KOmdx males were more prone to isoproterenol-induced heart failure and death compared with control groups."3.74Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification. ( Chu, AL; Chun, J; Elsherif, L; Huang, MS; Kaufman, SJ; Li, RY; Mekany, MA; Ross, RS; Shai, SY; Yang, Y, 2008)
"Isoproterenol could induce myocardial necrosis and apoptosis, TXLC could alleviate the myocardial injury through preventing myocardial cell necrosis and apoptosis."3.71[Experimental study of protective effect of tongxinluo capsule on isoproterenol induced myocardial injury in rats]. ( Liu, L; Wang, JR; Zhao, MZ, 2001)
"This study demonstrates that isoproterenol-induced myocardial necrosis resulted in progressive hemodynamic dysfunction of the left ventricle which most closely correlated with alterations in LV geometry."3.70Effect of left ventricular sphericity on the evolution of ventricular dysfunction in rats with diffuse isoproterenol-induced myocardial necrosis. ( Pfeffer, JM; Pfeffer, MA; Teerlink, JR, 1998)
"The present study compared the effects of amrinone, dobutamine, dibutyryl cAMP, digoxin, and isoproterenol on mechanical performance, the high energy phosphate metabolites, and the [Ca2+]i transients in normal and cardiomyopathic hamster hearts with severe heart failure."3.69Distinct modulation of myocardial performance, energy metabolism, and [Ca2+]i transients by positive inotropic drugs in normal and severely failing hamster hearts. ( Buser, PT; Jasmin, G; Parmley, WW; Wikman-Coffelt, J; Wu, SY, 1995)
"The present study was undertaken to compare the cardiomyopathies induced by experimental diabetes mellitus and chronic isoproterenol (ISO) pretreatment on inotropic reactivity of right ventricular strips from rats."3.68Pharmacological study of isoproterenol and diabetic cardiomyopathies in rat right ventricular strips. ( Gunasekaran, S; Tenner, TE; Young, JA, 1993)
"A study was designed to determine whether phenytoin (PHE) prevents the myocardial necrosis and subsequent fibrosis produced by isoproterenol (ISO)."3.68Influence of phenytoin on isoproterenol-induced myocardial fibrosis in rats. ( Besbasi, FS; Hamlin, RL, 1990)
"Lipid peroxidation as well as enzyme and isoenzyme activities in heart and blood plasma were investigated in 8- and 20-week-old SHR after administration of 40 mg/kg body weight isoproterenol in comparison to WKY rats in order to examine the susceptibility of the hearts of hypertensive animals towards catecholamine-induced damage."3.67Enhanced formation of lipid peroxides might contribute to the high sensitivity of spontaneously hypertensive rats towards isoproterenol-induced myocardial damage. ( Moritz, V; Papies, B; Schimke, I, 1989)
"Administration of a single high dose or multiple low doses of isoproterenol (ISO) to rats induces myocardial necrosis and cardiac hypertrophy."3.67Quantification of myocardial necrosis and cardiac hypertrophy in isoproterenol-treated rats. ( Brinkman, CJ; Knufman, NM; van der Laarse, A; Vliegen, HW, 1987)
"Isoproterenol-induced myocardial necrosis was examined in male mice with alloxan-induced and genetically transmitted diabetes."3.67Influence of the diabetic state on isoproterenol-induced cardiac necrosis. ( el-Hage, AN; Ferrans, VJ; Herman, EH; Jordan, AW, 1985)
"The new calcium antagonist anipamil (1,7-bis-(3-methoxyphenyl)-3-methylaza-7-cyano-nonadecane) exhibited a pronounced protective effect against isoprenaline-induced myocardial necrosis in rats."3.67Protective effect of the new calcium antagonist anipamil against isoprenaline-induced cardionecrosis in rats. ( Ciplea, AG; Heimann, W; Kirchengast, M; Kretzschmar, R; Safer, A, 1988)
"The role of thrombocytes in the production of isoproterenol-induced cardiac necrosis was investigated in rats rendered thrombocytopenic (A) as well as in rats treated with a prostacyclin analogue (B)."3.67Essential contribution of thrombocytes to the occurrence of catecholamine-induced cardiac necroses. ( Kammermeier, H; Ober, M, 1985)
"Studies on the rats with genetically-controlled hypertension (spontaneously hypertensive rats, SHR) in which myocardiopathy had been produced by isoproterenol (ISP) administration (2 X 80 mg/kg sc daily for two days) have shown that the myocardiopathy results in a fall of the activity of adenylate cyclase (AC) lasting from the second to the fourth day after administration of ISP, while the activity of phosphodiesterase (PDE) remained unchanged."3.66The activity of adenylate cyclase and phosphodiesterase in the isoproterenol-damaged cardiac muscle of spontaneously hypertensive rats. ( Piekarska, T, 1983)
"Isoproterenol-induced (5 mg/kg) disseminated necrosis of the rabbit myocardium led to a decrease in the efficiency of calcium pump of sarcoplasmic reticulum fragments."3.66[Effect of disseminated myocardial necrosis on ATPase activity, Ca2+ transport, and lipid peroxidation in cardiac mitochondrial and microsomal membranes]. ( Amarantova, GG; Chernysheva, GV; Kuz'mina, IL; Stoĭda, LV, 1980)
"Induction of myocardial necrosis by isoproterenol produces resistance to the necrogenic effects of subsequent doses of the drug."3.66Determinants of resistance to the cardiotoxicity of isoproterenol in rats. ( Balazs, T; Bloom, S; Joseph, X; Pledger, G, 1983)
" Isoproterenol-induced necrosis of the heart muscle leads to a decrease in both glutamine and alanine ability to bind ammonia (20--40 and 30--45%, respectively)."3.66[Neutralization of ammonia in cardiac muscle]. ( Minkovskiĭ, EB; Pisarenko, OI; Studneva, IM, 1980)
"The changes in myocardial copper were studied over a period of five days after producing myocardial necrosis in albino rats by subcutaneous injection of isoproterenol."3.66A temporal profile of changes in myocardial copper after isoproterenol induced cardiac necrosis. ( Ahmad, M; Jamil, SA; Kumar, S; Mahdi, SQ; Mathew, BM; Seth, TD, 1978)
"Trapidil increases the isoprenalin-induced necrosis of the myocardium in the rat."3.65[Modification of the isoprenaline-induced myocardial necrosis using trapidil]. ( Lampe, D; Lange, B; Mai, I, 1976)
" This is true for systemic hypoxia, hemorrhagic shock, and isoproterenol infusion."3.65Transmural metabolic gradients of the canine left ventricle in coronary constriction, systemic hypoxia, hemorrhagic shock, and isoproterenol infusion. ( Leunissen, RL, 1975)
" Therefore, the myocardial metabolism was studied at different environmental temperatures in albino rats with isoproterenol-induced infarct-like myocardial necrosis."3.65Myocardial metabolism at different environmental temperatures in experimental myocardial necrosis. ( Ahmad, M; Tajuddin, M; Tariq, M, 1975)
"Heart failure (HF), caused by stress cardiomyopathy, is a major cause of mortality."1.91Sodium houttuyfonate against cardiac fibrosis attenuates isoproterenol-induced heart failure by binding to MMP2 and p38. ( Adu-Amankwaah, J; An, K; Cui, J; Lin, L; Song, N; Sun, H; Tan, R; Wang, M; You, Q; Yuan, J, 2023)
"In 6 patients, arrhythmias were controlled after extracorporeal membrane oxygenation (ECMO) support; 5 of these patients survived."1.72Cardiac crises: Cardiac arrhythmias and cardiomyopathy during TANGO2 deficiency related metabolic crises. ( Azamian, M; Beach, CM; Ceresnak, SR; Delauz, CM; Ehsan, SA; Glinton, KE; Houck, KM; Howard, TS; Janson, CM; Jardine, K; Kannankeril, PJ; Kava, M; Kim, JJ; Lalani, SR; Lay, EJ; Li, N; Liberman, L; Macicek, SL; Milewicz, DM; Miyake, CY; Pham, TD; Robertson, T; Soler-Alfonso, C; Stephens, SB; Tosur, M; Valdes, SO; Webster, G; Xu, W; Zhang, L, 2022)
"Crocin has a protective effect on ISO-induced MF, which may be associated with the TLR4/NF-κB (p65) signal transduction pathway."1.56Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis. ( Cheng, J; Chu, L; Chu, X; Guan, S; Han, X; Jin, W; Li, Z; Ma, Z; Sun, S; Xue, Y; Zhang, X; Zhang, Y, 2020)
"Myocardial fibrosis is well-known to be the aberrant deposition of extracellular matrix (ECM), which may cause cardiac dysfunction, morbidity, and death."1.56Si-Miao-Yong-An Decoction attenuates isoprenaline-induced myocardial fibrosis in AMPK-driven Akt/mTOR and TGF-β/SMAD3 pathways. ( Chen, Y; Meng, Q; Sun, D; Yao, X; Zhan, K; Zhang, X; Zhao, Y; Zhu, L, 2020)
"Fibrosis was induced by ISO administration (5 mg/kg/d subcutaneously) for 10 days."1.51Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats. ( Che, Y; Jin, YG; Shen, DF; Wang, SS; Wang, ZP; Wu, QQ; Yuan, Y, 2019)
"However, its potential effect on cardiac hypertrophy remains unclear."1.51Chrysophanol attenuated isoproterenol-induced cardiac hypertrophy by inhibiting Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway. ( Bi, X; Hong, H; Lu, J; Wang, J; Ye, J; Yu, Y; Yuan, J; Zhang, Y, 2019)
"Isoproterenol (ISO) has been widely used to establish cardiac injury in vivo and in vitro."1.46Shikonin ameliorates isoproterenol (ISO)-induced myocardial damage through suppressing fibrosis, inflammation, apoptosis and ER stress. ( Chen, DL; Wang, Z; Yang, J, 2017)
"Carnitine deficiency was induced in Wistar rats by adding 20 mmol/L of sodium pivalate to drinking water (P)."1.43A Moderate Carnitine Deficiency Exacerbates Isoproterenol-Induced Myocardial Injury in Rats. ( Arduini, A; Bonomini, M; Giudice, PL, 2016)
"The metabolic syndrome is associated with prolonged stress and hyperactivity of the sympathetic nervous system and afflicted subjects are prone to develop cardiovascular disease."1.43The Role of Reactive Oxygen Species in β-Adrenergic Signaling in Cardiomyocytes from Mice with the Metabolic Syndrome. ( Andersson, DC; Fauconnier, J; Jardemark, K; Katz, A; Lanner, JT; Llano-Diez, M; Sinclair, J; Westerblad, H; Yamada, T; Zhang, SJ; Zong, M, 2016)
"Fibrosis was markedly increased by ISO."1.42l-Arginine Attenuates Cardiac Dysfunction, But Further Down-Regulates α-Myosin Heavy Chain Expression in Isoproterenol-Induced Cardiomyopathy. ( Babal, P; Doka, G; Janega, P; Klimas, J; Kralova, E; Krenek, P; Kuracinova, K; Pivackova, L; Srankova, J, 2015)
"Transgenic overexpression of SSPN in Duchenne muscular dystrophy mice (mdx(TG)) improved cardiomyofiber cell adhesion, sarcolemma integrity, cardiac functional parameters, as well as increased expression of compensatory transmembrane proteins that mediate attachment to the extracellular matrix."1.42Sarcospan Regulates Cardiac Isoproterenol Response and Prevents Duchenne Muscular Dystrophy-Associated Cardiomyopathy. ( Crosbie-Watson, RH; Jordan, MC; Marshall, JL; Nguyen, RT; Parvatiyar, MS; Richardson, VA; Roos, KP, 2015)
"Cardiac fibrosis is an important process in pathological cardiac remodeling and leads to heart failure."1.40Danshensu inhibits β-adrenergic receptors-mediated cardiac fibrosis by ROS/p38 MAPK axis. ( Jia, P; Li, Z; Lu, H; Tian, A; Wu, J; Xing, R; Yang, C; Yang, L; Zhang, Y; Zheng, X, 2014)
" This reduction was maintained throughout chronic dosing at day 15."1.39Interleukin-1β induces a reversible cardiomyopathy in the mouse. ( Abbate, A; Mezzaroma, E; Seropian, IM; Toldo, S; Van Tassell, BW, 2013)
" Isoprenaline (ISO), a β-adrenoceptor agonist, was infused at variable dosage and duration using either subcutaneously implanted osmotic minipumps or daily injections, in an attempt to establish the relevant treatment protocol."1.37Myocardial structural, contractile and electrophysiological changes in the guinea-pig heart failure model induced by chronic sympathetic activation. ( Olesen, SP; Osadchii, OE; Soltysinska, E, 2011)
"Cardiomyopathy in Duchenne muscular dystrophy (DMD) is an increasing cause of death in patients."1.37Membrane sealant Poloxamer P188 protects against isoproterenol induced cardiomyopathy in dystrophin deficient mice. ( Guerron, AD; Hoffman, EP; Nagaraju, K; Sali, A; Spurney, CF; van der Meulen, JH; Yu, Q, 2011)
"Nearly universal cardiomyopathy in Duchenne muscular dystrophy (DMD) contributes to heart failure and death."1.37Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice. ( Canan, BD; Chimanji, NS; Delfín, DA; Ganguly, R; Janssen, PM; Martin, CD; Mays, TA; Murray, JD; Rafael-Fortney, JA; Raman, SV; Schill, KE; Stangland, JE; Tran, T; Xu, Y, 2011)
"Treatment with isoproterenol (iso) for 7 days caused myocardial damage and left ventricular (LV) dysfunction in the cardiomyopathic mice."1.35Granulocyte-colony stimulating factor increases donor mesenchymal stem cells in bone marrow and their mobilization into peripheral circulation but does not repair dystrophic heart after bone marrow transplantation. ( Adachi, Y; Enoki, C; Ikehara, S; Imamura, H; Iwasaka, T; Kaneko, K; Otani, H; Sato, D; Taniuchi, S; Tatsumi, K, 2008)
"Cardiac hypertrophy is associated with a reduction in the contractile response to beta-adrenergic stimulation, and with re-expression of foetal genes such as beta-myosin heavy chain (MHC)."1.35Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain. ( Pandya, K; Porter, K; Rockman, HA; Smithies, O, 2009)
"Pre-treatment with ocotillol could attenuate the changes of both SOD and MDA."1.34Cardioprotective effect of ocotillol, a derivate of pseudoginsenoside F11, on myocardial injury induced by isoproterenol in rats. ( Fu, F; Han, B; Yu, C; Yu, X; Zhu, M, 2007)
"These changes predispose to cardiac arrhythmias and terminal heart failure and are thus important in the pathogenesis of mitochondrial cardiomyopathy."1.33Abnormal Ca(2+) release and catecholamine-induced arrhythmias in mitochondrial cardiomyopathy. ( Hansson, A; Larsson, NG; Tavi, P; Westerblad, H; Zhang, SJ, 2005)
" Thus, a range of low Iso doses can cause myocardial lesions, and serum cTnT levels can be monitored to detect the onset and progression of this type of acute cardiac injury in rats; however, careful attention to dosing and sampling times is critical to interpretation."1.33Serum cardiac troponin T as a biomarker for acute myocardial injury induced by low doses of isoproterenol in rats. ( Herman, E; Knapton, A; Lipshultz, SE; Rifai, N; Sistare, F; Zhang, J, 2006)
"The tachycardias were nonsustained in 24 patients, sustained (greater than 30 sec) in six patients, and provocable by exercise in 14 of 23 patients undergoing a standard Bruce protocol."1.27Right ventricular tachycardia: clinical and electrophysiologic characteristics. ( Buxton, AE; Cassidy, D; Josephson, ME; Marchlinski, FE; Simson, MB; Waxman, HL, 1983)
"Isoproterenol treatment (80 mg/kg given over two days in two equal doses) caused more than 100 percent increase in the MDA content which was prevented by pretreatment of the animals with vitamin E (alpha-tocopherol acetate, 10 mg/kg) for two weeks."1.27Potential oxidative pathways of catecholamines in the formation of lipid peroxides and genesis of heart disease. ( Beamish, RE; Dhalla, NS; Singal, PK, 1983)
" The phenomenon described might elucidate pathogenetic mechanisms behind toxic myocardial cell degeneration and may possibly have relevance for acute cardiovascular complications in diabetic patients."1.27Acute insulin treatment normalizes the resistance to the cardiotoxic effect of isoproterenol in streptozotocin diabetic rats. A morphometric study of isoproterenol induced myocardial fibrosis. ( Gøtzsche, O, 1985)
" Changes in hydrazinophthalazine-treated rats after dosing them with isoprenaline had a similar tendency but they were significantly lower than those found in healthy animals receiving isoprenaline only."1.27Effect of isoprenaline on tissue elastin content and serum elastolytic activity in normal and hydrazinophthalazine-treated rats. ( Drózdz, M; Kucharz, E; Olczyk, K; Wieczorek, M, 1987)
"Isoproterenol has been used experimentally and clinically to elicit ischemia."1.27Relation between graded, subcritical impairments of coronary flow reserve and regional myocardial dysfunction induced by isoproterenol infusion in dogs. ( DeBoe, SF; Friedman, HZ; Hramiec, JE; Mancini, GB, 1987)
"Rats were injected intraperitoneally with isoproterenol in dosage of 40 mg/kg body weight and heart microsomal and mitochondrial fractions were isolated 3, 9 and 24 h later."1.27Adaptive changes in subcellular calcium transport during catecholamine-induced cardiomyopathy. ( Beamish, RE; Dhalla, KS; Dhalla, NS; Ganguly, PK; Panagia, V; Pierce, GN, 1985)
" Repetition of the dose-response to isoprenaline in the presence of the beta-adrenergic antagonist propranolol (0."1.27Isoprenaline-evinced disturbances in action potentials from hearts of young cardiomyopathic hamsters. ( Rossner, KL, 1985)
"Furthermore, the resistance to anoxia of their isolated right ventricle was higher than that of virgin females."1.26The effect of pregnancy and lactation on the development of experimental heart lesions. ( Faltová, E; Mráz, M; Procházka, J; Sedivý, J, 1980)
"Isoproterenol treatment (80 mg/kg given over 2 days in two equal doses) caused arrhythmias and 25% mortality within 24 h of the last injection."1.26Role of free radicals in catecholamine-induced cardiomyopathy. ( Beamish, RE; Dhalla, NS; Dhillon, KS; Kapur, N; Singal, PK, 1982)
"The effect of inhibiting isoprenaline-induced intracellular calcium accumulation on the degree of damage produced in the rat myocardium by this amine has been investigated by simultaneously dosing rats with the calcium antagonistic drug D600."1.26The effect of a calcium antagonist (D600) on isoprenaline-induced myocardial necrosis in the rat. ( Powell, T; Rowles, PM; Steen, E; Woolf, N, 1979)
"Propranolol pretreatment decreased the accumulation of radioactivity in a dose-dependent fashion."1.26Quantitation of isoproterenol-induced myocardial necrosis with 3H-tetracycline. ( Athari-Nejad, A; Holcslaw, TL; Ryan, CF, 1979)
"Pretreatment with propranolol and pargyline protected against ISO-induced necrosis and myocardial hypertrophy, but did not influence the ISO-induced depletion of NE stores."1.25Alterations in norepinephrine pattern in the damaged myocardium in the rat. ( Bhagat, B; Dhalla, NS; Sullivan, JM, 1975)
"Patients with cardiac disorders have defective parasympathetic control of heart rate."1.25Impairment of autonomically mediated heart rate control in patients with cardiac dysfunction. ( Beiser, GD; Epstein, SE; Goldstein, RE; Stampfer, M, 1975)
"In patients with constrictive pericarditis, peak negative dp/dt varied during pulsus paradoxus: the linear relationship to peak positive dp/dt was maintained throughout the respiratory cycle."1.25Maximal rate of fall of left ventricular pressure in cardiomyopathy and constrictive pericarditis. ( Gotsman, MS; Lewis, BS, 1975)

Research

Studies (340)

TimeframeStudies, this research(%)All Research%
pre-1990167 (49.12)18.7374
1990's38 (11.18)18.2507
2000's40 (11.76)29.6817
2010's72 (21.18)24.3611
2020's23 (6.76)2.80

Authors

AuthorsStudies
Yáñez-Bisbe, L1
Garcia-Elias, A1
Tajes, M1
Almendros, I1
Rodríguez-Sinovas, A1
Inserte, J1
Ruiz-Meana, M1
Farré, R1
Farré, N1
Benito, B1
Wang, F2
Zhang, J3
Niu, G1
Weng, J1
Zhang, Q3
Xie, M2
Li, C1
Sun, K1
Miyake, CY1
Lay, EJ1
Beach, CM1
Ceresnak, SR1
Delauz, CM1
Howard, TS1
Janson, CM1
Jardine, K1
Kannankeril, PJ1
Kava, M1
Kim, JJ1
Liberman, L1
Macicek, SL1
Pham, TD1
Robertson, T1
Valdes, SO1
Webster, G1
Stephens, SB1
Milewicz, DM1
Azamian, M1
Ehsan, SA1
Houck, KM1
Soler-Alfonso, C1
Glinton, KE1
Tosur, M1
Li, N2
Xu, W2
Lalani, SR1
Zhang, L2
Li, M1
Tan, H1
Gao, T1
Han, L1
Teng, X1
Zhang, X4
Lunardon, G1
de Oliveira Silva, T1
Lino, CA1
Lu, YW1
Miranda, JB1
Asprino, PF1
de Almeida Silva, A1
Nepomuceno, GT1
Irigoyen, MCC1
Carneiro-Ramos, MS1
Takano, APC1
Martinho, HDS1
Barreto-Chaves, MLM1
Wang, DZ1
Diniz, GP1
Hayashi, T1
Tiwary, SK1
Lim, KRQ1
Rocha-Resende, C1
Kovacs, A1
Weinheimer, C1
Mann, DL1
Tan, R1
You, Q1
Cui, J2
Wang, M2
Song, N1
An, K1
Lin, L1
Adu-Amankwaah, J1
Yuan, J2
Sun, H1
Lillo, MA1
Muñoz, M1
Rhana, P1
Gaul-Muller, K1
Quan, J1
Shirokova, N1
Xie, LH1
Santana, LF1
Fraidenraich, D1
Contreras, JE1
Xing, Z1
Yang, C2
Feng, Y1
He, J1
Peng, C1
Li, D1
Jin, W1
Zhang, Y6
Xue, Y1
Han, X1
Ma, Z2
Sun, S1
Chu, X1
Cheng, J2
Guan, S1
Li, Z3
Chu, L1
Che, Y1
Shen, DF1
Wang, ZP1
Jin, YG1
Wu, QQ1
Wang, SS1
Yuan, Y1
Qian, L2
Li, J1
Ming, H1
Fang, L2
Li, Y1
Zhang, M1
Xu, Y2
Ban, Y1
Zhang, W1
Liu, Y3
Wang, N1
Ren, Q1
Lin, P1
Wang, Q1
Zhang, B2
Feng, L2
Ouyang, F1
Liu, X2
Liu, G1
Qiu, H1
He, Y2
Hu, H1
Jiang, P1
Sun, W1
Han, J1
Cheng, S1
Yu, P1
Shen, L1
Fan, M1
Tong, H1
Zhang, H2
Chen, J1
Chen, X4
Zhou, T1
Wang, J5
Xu, J1
Zheng, C1
Niu, Y1
Wang, C1
Xu, F1
Yuan, L1
Zhao, X1
Liang, L1
Xu, P1
Liu, M2
Feng, J1
Du, Q1
Ai, J1
Lv, Z1
Chaudhary, R1
Singh, R1
Verma, R1
Kumar, P1
Kumar, N1
Singh, L1
Kumar S, S1
Hu, C1
Zhang, N1
Wei, WY1
Li, LL1
Wu, HM1
Ma, ZG1
Tang, QZ1
Zhao, Y1
Sun, D1
Chen, Y4
Zhan, K1
Meng, Q2
Zhu, L1
Yao, X1
Mutneja, E1
Verma, VK1
Malik, S1
Sahu, AK1
Ray, R1
Bhatia, J1
Arya, DS1
Petersen, J1
Kloth, B1
Iqbal, S1
Reichenspurner, H1
Geelhoed, B1
Schnabel, R1
Eschenhagen, T3
Christ, T1
Girdauskas, E1
Yun, W1
Yuan, R1
Xu, H2
Sullivan, RT1
Lam, NT1
Haberman, M1
Beatka, MJ1
Afzal, MZ1
Lawlor, MW1
Strande, JL1
Viczenczova, C1
Kura, B1
Chaudagar, KK1
Szeiffova Bacova, B1
Egan Benova, T1
Barancik, M1
Knezl, V1
Ravingerova, T1
Tribulova, N3
Slezak, J3
Yang, J2
Wang, Z1
Chen, DL1
Ben-Shoshan, J1
Jubran, A1
Levy, R1
Keren, G1
Entin-Meer, M1
Kalkan, F1
Parlakpinar, H1
Disli, OM1
Tanriverdi, LH1
Ozhan, O1
Polat, A1
Cetin, A1
Vardi, N1
Otlu, YO1
Acet, A1
Park, S1
Ranjbarvaziri, S1
Lay, FD1
Zhao, P1
Miller, MJ1
Dhaliwal, JS1
Huertas-Vazquez, A1
Wu, X2
Qiao, R1
Soffer, JM1
Rau, C1
Wang, Y3
Mikkola, HKA1
Lusis, AJ2
Ardehali, R1
Pinotti, MF1
Matias, AM1
Sugizaki, MM1
Nascimento, AFD1
Pai, MD1
Leopoldo, APL1
Cicogna, AC1
Leopoldo, AS1
Koga, M1
Kuramochi, M1
Karim, MR1
Izawa, T1
Kuwamura, M1
Yamate, J1
Li, AY1
Wang, JJ2
Yang, SC1
Zhao, YS1
Li, JR1
Sun, JH1
An, LP1
Guan, P1
Ji, ES1
Meyers, TA1
Heitzman, JA1
Krebsbach, AM1
Aufdembrink, LM1
Hughes, R1
Bartolomucci, A1
Townsend, D1
Shen, W1
Zhang, JY1
Jia, CH1
Xie, ML1
Hong, H1
Lu, J1
Yu, Y1
Bi, X1
Ye, J1
Wang, L3
Yuan, D1
Zheng, J1
Zhang, C1
Liu, C1
Wang, T2
Zhou, Z1
Sadayappan, S1
Gilbert, RJ1
Gupta, P1
Kanwal, A1
Putcha, UK1
Bulani, Y1
Sojitra, B1
Khatua, TN1
Kuncha, M1
Banerjee, SK1
Lai, L1
Yan, L3
Gao, S1
Hu, CL1
Ge, H1
Davidow, A1
Park, M1
Bravo, C1
Iwatsubo, K1
Ishikawa, Y1
Auwerx, J1
Sinclair, DA1
Vatner, SF3
Vatner, DE3
Van Tassell, BW1
Seropian, IM1
Toldo, S1
Mezzaroma, E1
Abbate, A1
Jin, H2
Liu, AD1
Holmberg, L1
Zhao, M1
Chen, S3
Sun, Y1
Tang, C2
Du, J2
Chen, F2
Hadfield, JM1
Berzingi, C1
Hollander, JM1
Miller, DB1
Nichols, CE1
Finkel, MS2
Merlet, N1
Piriou, N1
Rozec, B1
Grabherr, A1
Lauzier, B1
Trochu, JN1
Gauthier, C1
Nayyar, S1
Roberts-Thomson, KC1
Hasan, MA1
Sullivan, T1
Harrington, J1
Sanders, P3
Baumert, M1
Al-Yahya, MA1
Mothana, RA2
Al-Said, MS1
El-Tahir, KE1
Al-Sohaibani, M2
Rafatullah, S2
Liu, L4
Aguirre, SA1
Evering, WE1
Hirakawa, BP1
May, JR1
Palacio, K1
Stevens, GJ1
Yang, Q1
Jia, C1
Xiong, M1
Ning, B1
Du, X1
Wang, P1
Yu, X3
Li, L1
Wang, W2
Zhang, T2
Lu, H1
Tian, A1
Wu, J1
Xing, R1
Jia, P1
Yang, L1
Zheng, X1
Mielcarek, M1
Bondulich, MK1
Inuabasi, L1
Franklin, SA1
Muller, T1
Bates, GP1
Kasa, JK1
Singh, TU1
Parida, S1
Addison, MP1
Darzi, SA1
Choudhury, S2
Kandasamy, K1
Singh, V1
Dash, JR1
Shanker, K1
Mishra, SK1
Willis, BC1
Salazar-Cantú, A1
Silva-Platas, C1
Fernández-Sada, E1
Villegas, CA1
Rios-Argaiz, E1
González-Serrano, P1
Sánchez, LA1
Guerrero-Beltrán, CE1
García, N1
Torre-Amione, G1
García-Rivas, GJ1
Altamirano, J1
Panda, S1
Kar, A1
Carll, AP3
Haykal-Coates, N3
Winsett, DW3
Hazari, MS3
Ledbetter, AD2
Richards, JH2
Cascio, WE2
Costa, DL3
Farraj, AK3
Lee, GJ1
Taghavi, S1
Sharp, TE1
Duran, JM1
Makarewich, CA1
Berretta, RM2
Starosta, T1
Kubo, H2
Barbe, M2
Houser, SR2
Kralova, E1
Doka, G1
Pivackova, L1
Srankova, J1
Kuracinova, K1
Janega, P1
Babal, P1
Klimas, J1
Krenek, P1
Thoonen, R1
Ernande, L1
Nagasaka, Y1
Yao, V1
Miranda-Bezerra, A1
Chen, C1
Chao, W1
Panagia, M1
Sosnovik, DE1
Puppala, D1
Armoundas, AA1
Hindle, A1
Bloch, KD1
Buys, ES1
Scherrer-Crosbie, M1
Grimm, M1
Ling, H1
Willeford, A1
Pereira, L1
Gray, CB1
Erickson, JR1
Sarma, S2
Respress, JL1
Wehrens, XH2
Bers, DM1
Brown, JH1
Xie, Y1
Montaudon, E1
Dubreil, L1
Lalanne, V1
Vermot Des Roches, M1
Toumaniantz, G1
Fusellier, M1
Desfontis, JC1
Martignat, L1
Mallem, MY1
Zhou, X1
Cai, JJ1
Chen, LZ1
Gong, YS1
Wang, LX1
Gao, Z1
Zhang, HQ1
Huang, WJ1
Zhou, H1
Roof, SR1
Boslett, J1
Russell, D1
del Rio, C1
Alecusan, J1
Zweier, JL1
Ziolo, MT1
Hamlin, R1
Mohler, PJ1
Curran, J1
Wang, S2
Lu, Z1
Deng, W1
Chen, QW1
Li, XS1
Yuan, ZM1
Li, GQ1
Ke, DZ1
Wu, ZQ1
Luo, SL1
Liu, Q1
Wang, K1
Lu, D1
Geng, J1
Fang, P1
Shan, Q1
Parvatiyar, MS1
Marshall, JL1
Nguyen, RT1
Jordan, MC1
Richardson, VA1
Roos, KP1
Crosbie-Watson, RH1
Al-Yahya, M1
Raish, M1
AlSaid, MS1
Ahmad, A1
Al-Dosari, MS1
Parvez, MK1
Giudice, PL1
Bonomini, M1
Arduini, A1
Lai, CC1
Liu, CP1
Cheng, PW1
Lu, PJ1
Hsiao, M1
Lu, WH1
Sun, GC1
Liou, JC1
Tseng, CJ1
Saeedi Saravi, SS1
Ghazi-Khansari, M1
Ejtemaei Mehr, S1
Nobakht, M1
Mousavi, SE1
Dehpour, AR2
Rau, CD1
Romay, MC1
Tuteryan, M1
Santolini, M1
Ren, S1
Karma, A1
Weiss, JN1
Llano-Diez, M1
Sinclair, J1
Yamada, T1
Zong, M1
Fauconnier, J1
Zhang, SJ2
Katz, A1
Jardemark, K1
Westerblad, H2
Andersson, DC1
Lanner, JT1
Vutharadhi, S1
Jolapuram, U1
Kodidhela, LD1
Ning, BB1
Wu, DD1
Cui, JG1
Wang, PW1
Wang, WJ1
Zhu, WL1
Stapel, B1
Kohlhaas, M1
Ricke-Hoch, M1
Haghikia, A1
Erschow, S1
Knuuti, J1
Silvola, JM1
Roivainen, A1
Saraste, A1
Nickel, AG1
Saar, JA1
Sieve, I1
Pietzsch, S1
Müller, M1
Bogeski, I1
Kappl, R1
Jauhiainen, M1
Thackeray, JT1
Scherr, M1
Bengel, FM1
Hagl, C1
Tudorache, I1
Bauersachs, J1
Maack, C1
Hilfiker-Kleiner, D1
Angelone, T1
Quintieri, AM1
Brar, BK1
Limchaiyawat, PT1
Tota, B1
Mahata, SK1
Cerra, MC1
Tatsumi, K1
Otani, H1
Sato, D1
Enoki, C1
Iwasaka, T1
Imamura, H1
Taniuchi, S1
Kaneko, K1
Adachi, Y1
Ikehara, S1
Amour, J1
Loyer, X1
Michelet, P1
Birenbaum, A1
Riou, B1
Heymes, C1
Campos, EC1
Romano, MM1
Prado, CM1
Rossi, MA1
Ceolotto, G1
Papparella, I1
Sticca, A1
Bova, S1
Cavalli, M1
Cargnelli, G1
Semplicini, A1
Gatta, A1
Angeli, P1
Gao, HC1
Ren, LQ1
Yu, XY1
Sun, B1
Miao, CS1
Shi, Y1
Li, XJ1
Wang, D1
Zhao, J1
Kan, H1
Hobbs, G1
Hu, Y1
Guo, DH1
Liu, P1
Rahman, K1
Wang, DX1
Wang, B1
Bilginoglu, A1
Seymen, A1
Tuncay, E1
Zeydanli, E1
Aydemir-Koksoy, A1
Turan, B1
Pandya, K1
Porter, K1
Rockman, HA1
Smithies, O1
Minomo, H1
Torikai, Y1
Furukawa, T1
Uchino, H1
Kadokura, H1
Nakama, K1
Maeda, H1
Kamenosono, T1
Sukamoto, T1
Fukuzaki, K1
Nagata, R1
Rowan, WH1
Nyska, A2
Watkinson, WP1
Mori, Y1
Kondo, C1
Tonomura, Y1
Torii, M1
Uehara, T1
Qu, S1
Han, B3
Sui, D1
Serra, AJ1
Santos, MH1
Bocalini, DS1
Antônio, EL1
Levy, RF1
Santos, AA1
Higuchi, ML1
Silva, JA1
Magalhães, FC1
Baraúna, VG1
Krieger, JE1
Tucci, PJ1
van Oort, RJ1
Reynolds, C1
Skapura, DG1
Liang, Y1
Liu, D1
Ochs, T1
Zhang, S1
Geng, B1
Angert, D1
Ogorek, B1
Li, Q1
Bi, Y1
Jiang, N1
Soltysinska, E1
Olesen, SP1
Osadchii, OE1
Spurney, CF1
Guerron, AD1
Yu, Q1
Sali, A1
van der Meulen, JH1
Hoffman, EP1
Nagaraju, K1
Singh, BK1
Pillai, KK1
Kohli, K1
Haque, SE1
Rafael-Fortney, JA1
Chimanji, NS1
Schill, KE1
Martin, CD1
Murray, JD1
Ganguly, R1
Stangland, JE1
Tran, T1
Canan, BD1
Mays, TA1
Delfín, DA1
Janssen, PM1
Raman, SV1
Willis, MS1
Chen, R1
Xue, J1
Hasić, S1
Jadrić, R1
Cosović, E1
Kiseljaković, E1
Mornjaković, Z1
Winterhalter-Jadrić, M1
Johnson, CM1
Pogwizd, SM1
Vaseghi, M1
Lux, RL1
Mahajan, A1
Shivkumar, K1
Shetty, AK1
Linton, NW1
Wright, M1
O'Neill, MD1
Liao, HC1
Zhou, B1
Remião, F1
Carmo, H1
Carvalho, F1
Bastos, ML1
Morton, JB2
Morgan, JG1
Davidson, NC1
Spence, SJ1
Vohra, JK2
Kalman, JM2
Sparks, PB2
Zhao, MZ1
Wang, JR1
RONA, G6
CHAPPEL, CI1
BALAZS, T3
GAUDRY, R1
WIGLE, ED2
DAVID, PR1
LABROOSE, CJ1
MCMEEKAN, J1
KLEIN, MD1
LANE, FJ1
GORLIN, R1
Kistler, PM1
Bos, R1
Mougenot, N1
Médiani, O1
Vanhoutte, PM1
Lechat, P1
Elsherif, L2
Saari, JT1
Kang, YJ1
Yue, Y1
Skimming, JW1
Strawn, T1
Duan, D1
Frey, N1
Barrientos, T1
Shelton, JM1
Frank, D1
Rütten, H1
Gehring, D1
Kuhn, C1
Lutz, M1
Rothermel, B1
Bassel-Duby, R1
Richardson, JA1
Katus, HA1
Hill, JA1
Olson, EN1
Tavi, P1
Hansson, A1
Larsson, NG1
Hassan, MA1
Ketat, AF1
Woldbaek, PR1
Sande, JB1
Strømme, TA1
Lunde, PK1
Djurovic, S1
Lyberg, T1
Christensen, G1
Tønnessen, T1
Cole, MP1
Chaiswing, L1
Oberley, TD1
Edelmann, SE1
Piascik, MT1
Lin, SM1
Kiningham, KK1
St Clair, DK1
Ebrahimi, F1
Tavakoli, S1
Hajrasouliha, AR1
Shafaroodi, H1
Sadeghipour, H1
Riazi, K1
Borhani, AA1
Houshmand, G1
Ahmadi, SH1
Meng, D1
Chen, XJ1
Yang, D1
Zhang, JN1
Matkovich, SJ1
Diwan, A1
Klanke, JL1
Hammer, DJ1
Marreez, Y1
Odley, AM1
Brunskill, EW1
Koch, WJ1
Schwartz, RJ1
Dorn, GW2
Herman, E1
Knapton, A1
Lipshultz, SE1
Rifai, N1
Sistare, F1
de Boer, TP1
van Rijen, HV1
Van der Heyden, MA1
Kok, B1
Opthof, T1
Vos, MA1
Jongsma, HJ1
de Bakker, JM1
van Veen, TA1
Yu, C1
Fu, F1
Zhu, M1
Karthikeyan, K1
Sarala Bai, BR1
Niranjali Devaraj, S1
Xu, XL1
Ji, H1
Gu, SY1
Shao, Q1
Huang, QJ1
Cheng, YP1
Huang, MS1
Shai, SY1
Yang, Y1
Li, RY1
Chun, J1
Mekany, MA1
Chu, AL1
Kaufman, SJ1
Ross, RS1
Wexler, BC1
Kittinger, GW1
Judd, JT1
Bajusz, E2
Homburger, F1
Nellen, M1
Gotsman, MS2
Vogelpoel, L1
Beck, W1
Schrire, V1
Marquis, Y1
Aucer, P1
Mangold, I1
Bittmann, S1
Mester, B1
Uhlenhop, B1
Thäter, G1
Lindner, J1
Buxton, AE1
Waxman, HL1
Marchlinski, FE1
Simson, MB1
Cassidy, D1
Josephson, ME1
Nepomniashchikh, LM1
Lushnikova, EL2
Chernokalova, MG1
Tumanov, VP1
Cabrol, C1
Gandjbakhch, I1
Pavie, A1
Cabrol, A1
Mattei, MF1
Lienhart, A1
Gluckman, JC1
Rottembourg, J1
Tanaka, M2
Tsuchihashi, Y1
Katsume, H1
Ijichi, H1
Ibata, Y1
Bobik, A1
Korner, P1
Drózdz, M2
Piwowarczyk, B1
Olczyk, K2
Wieczorek, M2
Wróblewska-Adamek, I1
Piekarska, T1
Artman, M1
Parrish, MD1
Graham, TP1
Chernysheva, GV1
Stoĭda, LV1
Amarantova, GG1
Kuz'mina, IL1
Faltová, E6
Mráz, M4
Procházka, J1
Sedivý, J2
Protivová, L1
Pilný, J3
Jasmin, G3
Proschek, L1
Seth, SD4
Gupta, MP3
Gupta, M2
Manchanda, SC3
Fleckenstein, A7
Frey, M1
Fleckenstein-Grün, G1
Darsinos, JT1
Karli, JN1
Stathaki, SN1
Ziroyannis, PN1
Pistevos, AC1
Levis, GM1
Moulopoulos, SD1
Schulze, W1
Ostadal, B2
Pelouch, V2
Parizková, J1
Spátová, M1
Joseph, X1
Bloom, S4
Pledger, G1
Singal, PK2
Beamish, RE5
Dhalla, NS7
Welty, MC1
Welty, JD1
McBroom, MJ1
Jacobs, RL1
Koppes, GM1
Kapur, N1
Dhillon, KS1
Saxena, KK3
Gupta, B3
Srivastava, RK1
Singh, RC1
Prasad, DN3
Pinot, JJ1
Nebunu, JC1
Baille, Y1
Karliner, JS1
Alabaster, C1
Stephens, H1
Barnes, P1
Dollery, C1
Borgers, M1
Hara, H1
Ostrowski, J1
Pisarenko, OI1
Minkovskiĭ, EB1
Studneva, IM1
Kapiĭ, LP1
Boor, PJ2
Witte, K1
Olbrich, HG1
Langer, L1
Lemmer, B1
Bleuel, H1
Deschl, U1
Bertsch, T1
Bölz, G1
Rebel, W1
Gunasekaran, S1
Young, JA1
Tenner, TE1
Ouadid, H1
Albat, B1
Nargeot, J1
Diederich, M1
Kluge, SH1
Magnussen, O1
Mene, U1
Müller, F1
Schmitz, W4
Scholz, H4
Weil, J1
Sent, U1
Buser, PT1
Wu, SY1
Parmley, WW2
Wikman-Coffelt, J2
Spinale, FG1
Tempel, GE1
Mukherjee, R1
Eble, DM1
Brown, R1
Vacchiano, CA1
Zile, MR1
Kolin, A2
Brezina, A2
Mamelak, M2
Pandula, E2
Noda, N1
Hayashi, H1
Satoh, H1
Terada, H1
Hirano, M1
Kobayashi, A1
Yamazaki, N1
De Mello, WC1
Miyamoto, A1
Lee, SS3
Ishido, S1
Yokoyama, M1
Kitazawa, S1
Maeda, S1
Hasenfuss, G1
Mulieri, LA1
Allen, PD1
Just, H1
Alpert, NR1
Chernysh, IN1
Sadovnikov, VB1
Maulik, M1
Katiyar, CK1
Maulik, SK1
Teerlink, JR1
Pfeffer, JM1
Pfeffer, MA1
Kmonícková, E1
Nováková, O1
Tvrzická, E1
Hynie, S1
Maeda, A1
Honda, M1
Kuramochi, T1
Takabatake, T1
Flammang, D1
Erickson, M1
McCarville, S1
Church, T1
Hamani, D1
Donal, E1
Hoit, BD2
Castro, C1
Bultron, G1
Knight, S1
Matlib, MA1
Gordon, EA1
Guppy, LJ1
Bertinchant, JP1
Robert, E1
Polge, A1
Marty-Double, C1
Fabbro-Peray, P1
Poirey, S1
Aya, G1
Juan, JM1
Ledermann, B1
de la Coussaye, JE1
Dauzat, M1
Liu, H2
Song, D1
Dash, R1
Kadambi, V1
Schmidt, AG1
Tepe, NM1
Biniakiewicz, D1
Gerst, MJ1
Canning, AM1
Abraham, WT1
Liggett, SB1
Lorenz, JN1
Kranias, EG1
Beranek, JT1
Nepomnyashchikh, LM1
Semenov, DE1
Saito, T1
Ward, CA1
Funakoshi, H1
Kubota, T1
Kawamura, N1
Machida, Y1
Feldman, AM2
Tsutsui, H1
Shimokawa, H1
Takeshita, A1
Strubelt, O1
Siegers, CP1
Bhagat, B1
Sullivan, JM1
Janke, J5
Hein, B2
Leder, O4
Sigel, H2
Milei, J1
Vazquez, A1
Bolomo, N1
Ensslen, R1
Schwarz, F1
Thormann, J1
Schlepper, M1
Ciplea, AG3
Bock, PR2
Severson, JA1
Fell, RD1
Griffith, DR1
Amorim, DS1
Carneiro, JJ1
Gallo, L1
Rossi, A1
Manço, JC1
Neto, JA1
Sader, AA1
Morace, G1
Padeletti, L1
Porciani, MC1
Fantini, F1
Steen, E1
Woolf, N1
Powell, T1
Rowles, PM1
Strozzi, C1
Cocco, G1
Padovan, GC1
Srivastava, VK1
Kulshrestha, VK2
Ryan, CF1
Athari-Nejad, A1
Holcslaw, TL1
Bier, CB1
Recusani, F1
Sgalambro, A1
Fea, M1
Sarasso, G1
Richichi, I1
Tronconi, L1
Godfraind, T2
Sturbois, X2
Barnová, E1
Machán, V1
Kalincák, M1
Vilcek, S1
Barna, K1
Danis, J1
Mathew, BM1
Ahmad, M2
Kumar, S1
Seth, TD1
Mahdi, SQ1
Jamil, SA1
Gronert, GA1
Theye, RA1
Milde, JH1
Tinker, JH1
Goldstein, RE1
Beiser, GD1
Stampfer, M1
Epstein, SE1
Mai, I1
Lampe, D1
Lange, B1
Lewis, BS1
Leunissen, RL1
Tajuddin, M1
Tariq, M1
Vorbeck, ML1
Malewski, EF1
Erhart, LS1
Martin, AP1
Gudbjarnason, S1
Oskarsdóttir, G1
Lossnitzer, K2
Stauch, M2
Kanke, J1
Döring, HJ3
Adler, CP1
Lee, SL1
Ostadalova, I1
Kolar, F1
Bethke, T1
Klimkiewicz, A1
Kohl, C1
von der Leyen, H1
Mehl, H1
Mende, U3
Meyer, W1
Neumann, J1
Rosswag, S1
Raper, R1
Fisher, M1
Bihari, D1
Rote, WE1
Connor, JD1
Manjula, TS1
Geetha, A1
Ramesh, TG1
Devi, CS1
Chidiac, P1
Nagy, A1
Sole, MJ1
Wells, JW1
Schwinger, RH1
Böhm, M4
Erdmann, E1
Noguchi, K1
Kato, T1
Kinjo, N1
Moromizato, H1
Sakanashi, M1
Uzunova, P1
Sokolova, TZ1
Galabova, T1
Peneva, V2
Taskov, M2
Ribarov, S1
Harding, SE2
MacLeod, KT1
Jones, SM2
Vescovo, G1
Poole-Wilson, PA2
Klebanov, GI1
Naumov, OG1
Vladimirov, IuA1
Ribarov, SR1
Curti, C1
Uyemura, SA1
Grecchi, MJ1
Leone, FA1
Kirby, MS1
Vescova, G1
Wanless, RB1
Dalla Libera, LD1
Awaji, Y1
Hashimoto, H1
Matsui, Y1
Kawaguchi, K1
Okumura, K2
Ito, T1
Satake, T1
Besbasi, FS1
Hamlin, RL1
Cannon, EP1
Williams, BJ1
Kessler, PD1
Cates, AE1
Van Dop, C1
Stefenelli, T1
Wu, ST1
Mason, DT2
Papies, B1
Schimke, I1
Moritz, V1
Gendzhev, Z1
Petrova, V1
Stroev, EA1
Stroitelev, VV1
Astrakhantsev, AF1
Yunge, L1
Bruneval, P1
Cokay, MS1
Berry, B1
Peters, H2
Poulsen, R1
Hüttner, I3
Knufman, NM1
van der Laarse, A1
Vliegen, HW1
Brinkman, CJ1
el-Hage, AN1
Herman, EH1
Jordan, AW1
Ferrans, VJ2
Makino, N1
Janatová, T1
Krause, EG1
Galdiero, F1
Tufano, MA1
Rossi, F1
Filippelli, W1
De Santis, D1
Matera, C1
Berrino, L1
Marmo, E1
Kretzschmar, R1
Heimann, W1
Kirchengast, M1
Safer, A1
Gøtzsche, O1
Brückner, R1
Schäfer, H1
Mikisková, H1
Frantík, E1
Bestetti, RB1
Ramos, CP1
Figuerêdo-Silva, J1
Sales-Neto, VN1
Oliveira, JS1
Kucharz, E1
Mancini, GB1
Friedman, HZ1
Hramiec, JE1
DeBoe, SF1
Panagia, V2
Rossner, KL3
Mascarenhas, DA1
Mitova, M1
Bednarík, B1
Lupínek, Z1
Cerný, E1
Coudrai, PR1
Todd, GL2
Baroldi, G2
Pieper, GM2
Clayton, FC2
Eliot, RS2
Pavlenko, VS1
Slepushkin, VD1
Zoloev, GK1
Titov, MI1
Okerberg, CV1
Van Vleet, JF1
Meng, XZ1
Yu, WH1
Su, Y1
Gupta, JB1
Kammermeier, H1
Ober, M1
Pierce, GN1
Dhalla, KS1
Ganguly, PK1
Charnock, JS1
McLennan, PL1
Abeywardena, MY1
Dryden, WF1
Goodwin, JF2
Webb-Peplos, MM1
Croxson, RS1
Khanna, P1
Raphael, MJ1
Steiner, RE1
Oakley, CM1
Ohtake, S1
Cummings, JR1
Noble, JF1
Poupa, O2
Carlsten, A1
Stanton, HC1
Tourniaire, A1
Deyrieux, F1
Blum, J1
Tartulier, M1
Knieriem, HJ1
Meerson, FZ1
Mueller, RA1
Thoenen, H1
Koji, T1
Holub, P1
Weiss, M1
Inczinger, F2
Bózner, A1
Lukaciková, E1
Branzi, A1
Binetti, G1
Zannoli, R1
Magnani, B1
Davis, D1
Morin, Y1
Côté, G1
Horwitz, LD1
Curry, GC1
Parkey, RW1
Bonte, FJ1
Besse, P2
Daubeze, J1
Lardeau, P1
Choussat, A1
Bricaud, H2
Boutet, M3
Deyl, Z1
King, JF1
Salel, AF1
Amsterdam, EA1
Massumi, RA1
Zelis, R1
Albrecht, I1
Parízková, F1
Pilný, F1
Magnusson, G1
Hansson, E1
Dusek, J1
Pachinger, O1
Grimberg, D1
Acar, J1
Joly, F1
Humbert, G1
Terrasson, C1
Choussat, CA1
Broustet, JP1
Abbasi, AS1
MacAlpin, RN1
Eber, LM1
Pearce, ML1
Schlüter, G1
Kiefer, G1
Ino, T1
Toshima, H1
Fukami, T1
Hirzel, H1
Mahler, F1
Escher, J1
Ratti, R1
Wirz, P1
Bourdarias, JP3
Ourbak, P3
Penther, P1
Scebat, L3
Lenegre, J2
Chaturvedi, UC1
Mehrotra, RM1
Gvozdják, J1
Bada, V1
Kapeller, K1
Mráz, P1
Dornetzhuber, V1
Takatsu, T1
Kawai, C1
Tsutsumi, J1
Yamashita, K1
Inoue, K1
Schreiner, BF1
Murphy, CW1
James, DH1
Yu, PN1
Gould, L1
Zahir, M1
Calder, B1
Lyon, AF1
Saavedra, J1
Bianchi, C1
Vicuña, JP1
Escobar, E1
Meruane, J1
Duran, G1
Reyes, J1
Rodriguez, R1
Pfau, J1
Gehrung, E1
Maggiolo, P1
Rossler, E1
Gattiker, H1
Lichtlen, P1
Williams, JF1
Childress, RH1
Chip, JN1
Border, JF1
Moudgil, LR1
Lockhart, A2
Charpentier, A2
Hibbs, RG1
Walsh, JJ1
Burch, GE1
Ismail, MB1
Scriabine, A1
Stebbins, RB1
Wenzel, DG1
Chau, RY1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
BAT as a Therapeutic for the Metabolic and Cardiac Dysfunction With Senescence Pilot[NCT03793127]24 participants (Actual)Interventional2019-01-23Active, not recruiting
A Randomized Open Label Trial of Spironolactone Versus Prednisolone in Corticosteroid-naïve Boys With DMD[NCT03777319]Phase 12 participants (Actual)Interventional2018-12-05Terminated (stopped due to Inability to recruit participants.)
Cardiac Allograft Remodeling and Effects of Sirolimus on Its Progression[NCT01889992]Phase 142 participants (Actual)Interventional2013-04-24Terminated (stopped due to PI left University and project not continued)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Efficacy: Change in Time to Complete a 100 Meter Timed Test.

The determination of whether spironolactone has similar efficacy to glucocorticoids in improving muscle strength in steroid naïve DMD patients. This will be determined by measuring the time to complete a 100 meter timed test (100M). (NCT03777319)
Timeframe: 6 months

Interventionsec (Number)
Spironolactone-0.6
Prednisolone-5.3

Efficacy: Dynamometry Score

Secondary outcome measures will be Dynamometry score, which is a summation of maximum voluntary isometric contraction test values for knee flexion, knee extension, elbow flexion, and elbow extension (NCT03777319)
Timeframe: 6 months

,
Interventionkg (Number)
Elbow Flexion (Right)-BaselineElbow Flexion (Left)-BaselineElbow Extension (Right)-BaselineElbow Extension (Left)-BaselineKnee Flexion (Right)-BaselineKnee Flexion (Left)-BaselineKnee Extension (Right)-BaselineKnee Extension (Left)-BaselineElbow Flexion (Right)-Month 6Elbow Flexion (Left)-Month 6Elbow Extension (Right)-Month 6Elbow Extension (Left)-Month 6Knee Flexion (Right)-Month 6Knee Flexion (Left)-Month 6Knee Extension (Right)-Month 6Knee Extension (Left)-Month 6
Prednisolone3.64.15.34.13.33.44.85.22.93.44.33.84.13.965.1
Spironolactone00004.12.83.85.93.13.52.42.54.34.17.28.3

Safety Will be Monitored Through Regular Review of Electrolytes.

Electrolytes (Sodium, Potassium, Cloride and Carbon dioxide, mmol/L) will be measured on a monthly basis following initiation of either spironolactone or prednisolone. (NCT03777319)
Timeframe: 6 months

,
Interventionmmol/L (Number)
Sodium-BaselineSodium-Month 1Sodium-Month 2Sodium-Month 3Sodium-Month 4Sodium-Month 5Sodium-Month 6Potassium-BaselinePotassium-Month 1Potassium-Month 2Potassium-Month 3Potassium-Month 4Potassium-Month 5Potassium-Month 6Chloride-BaselineChloride-Month 1Chloride-Month 2Chloride-Month 3Chloride-Month 4Chloride-Month 5Chloride-Month 6CO2-BaselineCO2-Month 1CO2-Month 2CO2-Month 3CO2-Month 4CO2-Month 5CO2-Month 6
Prednisolone1401401391411391391433.844.53.94.64.23.910510510410510510610522242424252626
Spironolactone1421421411421391391404.54.74.24.14.54.54.310310910710310310310129222527282826

Reviews

8 reviews available for isoproterenol and Cardiomyopathies

ArticleYear
Congestive heart failure in childhood and adolescence: recognition and management.
    American heart journal, 1983, Volume: 105, Issue:3

    Topics: Adolescent; Captopril; Cardiomyopathies; Child; Digoxin; Dobutamine; Dopamine; Echocardiography; Ele

1983
Effects of magnesium deficiency on the pathogenesis of myocardial infarction.
    Magnesium, 1986, Volume: 5, Issue:3-4

    Topics: Action Potentials; Animals; Arteritis; Calcium; Cardiomyopathies; Cricetinae; Dogs; Electrolytes; Is

1986
Magnesium deficiency cardiomyopathy.
    The American journal of cardiovascular pathology, 1988, Volume: 2, Issue:1

    Topics: Animals; Cardiomyopathies; Coronary Vessels; Humans; Isoproterenol; Magnesium Deficiency; Myocardial

1988
Catecholamine cardiotoxicity.
    Journal of molecular and cellular cardiology, 1985, Volume: 17, Issue:4

    Topics: Animals; Calcium; Cardiomyopathies; Catecholamines; Cell Membrane Permeability; Coronary Circulation

1985
Experimental catecholamine-induced myocardial necrosis. I. Morphology, quantification and regional distribution of acute contraction band lesions.
    Journal of molecular and cellular cardiology, 1985, Volume: 17, Issue:4

    Topics: Animals; Cardiomyopathies; Catecholamines; Constriction, Pathologic; Dogs; Hemodynamics; Isoproteren

1985
Treatment of the cardiomyopathies.
    The American journal of cardiology, 1973, Sep-07, Volume: 32, Issue:3

    Topics: Adrenergic beta-Antagonists; Alcoholism; Angina Pectoris; Anticoagulants; Atrial Fibrillation; Blood

1973
[Morphological principles of cardiac hypertrophy].
    Verhandlungen der Deutschen Gesellschaft fur Kreislaufforschung, 1972, Volume: 38

    Topics: Adult; Anemia, Hypochromic; Animals; Cardiomegaly; Cardiomyopathies; Cardiomyopathy, Hypertrophic; C

1972
Toxic agents and cardiomyopathies.
    Cardiovascular clinics, 1972, Volume: 4, Issue:1

    Topics: Alcoholism; Animals; Autopsy; Cardiomyopathies; Cobalt; Disease Models, Animal; Drug-Related Side Ef

1972

Trials

2 trials available for isoproterenol and Cardiomyopathies

ArticleYear
Reversal of atrial mechanical stunning after cardioversion of atrial arrhythmias: implications for the mechanisms of tachycardia-mediated atrial cardiomyopathy.
    Circulation, 2002, Oct-01, Volume: 106, Issue:14

    Topics: Atrial Flutter; Atrial Function, Left; Calcium Chloride; Cardiac Pacing, Artificial; Cardiomyopathie

2002
Reversal of atrial mechanical dysfunction after cardioversion of atrial fibrillation: implications for the mechanisms of tachycardia-mediated atrial cardiomyopathy.
    Circulation, 2003, Oct-21, Volume: 108, Issue:16

    Topics: Adrenergic beta-Agonists; Atrial Fibrillation; Cardiac Pacing, Artificial; Cardiomyopathies; Chronic

2003

Other Studies

330 other studies available for isoproterenol and Cardiomyopathies

ArticleYear
Aging Impairs Reverse Remodeling and Recovery of Ventricular Function after Isoproterenol-Induced Cardiomyopathy.
    International journal of molecular sciences, 2021, Dec-24, Volume: 23, Issue:1

    Topics: Aging; Animals; Cardiomyopathies; Collagen; Disease Models, Animal; Female; Fibrosis; Gene Expressio

2021
Apigenin inhibits isoproterenol-induced myocardial fibrosis and Smad pathway in mice by regulating oxidative stress and miR-122-5p/155-5p expressions.
    Drug development research, 2022, Volume: 83, Issue:4

    Topics: Animals; Apigenin; Cardiomyopathies; Collagen; Fibrosis; Isoproterenol; Mice; MicroRNAs; NF-kappa B;

2022
Cardiac crises: Cardiac arrhythmias and cardiomyopathy during TANGO2 deficiency related metabolic crises.
    Heart rhythm, 2022, Volume: 19, Issue:10

    Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiomyopathies; Child; Heart Arrest; Humans; Isoprot

2022
Gypensapogenin I Ameliorates Isoproterenol (ISO)-Induced Myocardial Damage through Regulating the TLR4/NF-κB/NLRP3 Pathway.
    Molecules (Basel, Switzerland), 2022, Aug-19, Volume: 27, Issue:16

    Topics: Animals; Cardiomyopathies; Fibrosis; Isoproterenol; Mice; Mice, Inbred C57BL; Molecular Docking Simu

2022
Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction.
    Clinical science (London, England : 1979), 2022, 11-30, Volume: 136, Issue:21

    Topics: Animals; Cardiomegaly; Cardiomyopathies; Fibrosis; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Mi

2022
Refining the reproducibility of a murine model of stress-induced reversible cardiomyopathy.
    American journal of physiology. Heart and circulatory physiology, 2023, Feb-01, Volume: 324, Issue:2

    Topics: Animals; Cardiomyopathies; Disease Models, Animal; Female; Humans; Isoproterenol; Mice; Mice, Inbred

2023
Sodium houttuyfonate against cardiac fibrosis attenuates isoproterenol-induced heart failure by binding to MMP2 and p38.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 109

    Topics: Animals; Cardiomyopathies; Fibrosis; Heart Failure; Isoproterenol; Matrix Metalloproteinase 2; Mice;

2023
Remodeled connexin 43 hemichannels alter cardiac excitability and promote arrhythmias.
    The Journal of general physiology, 2023, 07-03, Volume: 155, Issue:7

    Topics: Animals; Arrhythmias, Cardiac; Cardiomyopathies; Connexin 43; Gap Junctions; Ion Channels; Isoproter

2023
Understanding aconite's anti-fibrotic effects in cardiac fibrosis.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2024, Volume: 122

    Topics: Aconitum; Animals; Cardiomyopathies; Collagen; Fibrosis; Galactose; Isoproterenol; Myocardium; Rats;

2024
Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis.
    Naunyn-Schmiedeberg's archives of pharmacology, 2020, Volume: 393, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Cardiomyopathies; Cardiotonic Agents; Carotenoids; Fibrosis; Isop

2020
Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats.
    BMC cardiovascular disorders, 2019, 10-15, Volume: 19, Issue:1

    Topics: Animals; Berberine; Cardiomyopathies; Cell Transdifferentiation; Cells, Cultured; Coculture Techniqu

2019
GHSR deficiency exacerbates cardiac fibrosis: role in macrophage inflammasome activation and myofibroblast differentiation.
    Cardiovascular research, 2020, 11-01, Volume: 116, Issue:13

    Topics: Animals; Cardiomyopathies; Cell Transdifferentiation; Cells, Cultured; Disease Models, Animal; Extra

2020
Chronic peripheral ghrelin injection exerts antifibrotic effects by increasing growth differentiation factor 15 in rat hearts with myocardial fibrosis induced by isoproterenol.
    Physiological research, 2020, 07-16, Volume: 69, Issue:3

    Topics: Adrenergic beta-Agonists; Animals; Cardiomyopathies; Disease Models, Animal; Fibrosis; Ghrelin; Grow

2020
Long non-coding RNA RNF7 promotes the cardiac fibrosis in rat model via miR-543/THBS1 axis and TGFβ1 activation.
    Aging, 2020, 01-08, Volume: 12, Issue:1

    Topics: Animals; Biomarkers; Biopsy; Cardiomyopathies; Disease Models, Animal; Disease Susceptibility; Extra

2020
The circular RNA hsa_circ_0007623 acts as a sponge of microRNA-297 and promotes cardiac repair.
    Biochemical and biophysical research communications, 2020, 03-19, Volume: 523, Issue:4

    Topics: Animals; Base Sequence; Cardiomyopathies; Cell Movement; Cell Proliferation; Gene Expression Regulat

2020
A Smart Fluorescent Probe for NO Detection and Application in Myocardial Fibrosis Imaging.
    Analytical chemistry, 2020, 04-07, Volume: 92, Issue:7

    Topics: Animals; Cardiomyopathies; Cells, Cultured; Electron Transport; Fibrosis; Fluorescent Dyes; Humans;

2020
Paeoniflorin Attenuates Myocardial Fibrosis in Isoprenaline-induced Chronic Heart Failure Rats via Inhibiting P38 MAPK Pathway.
    Current medical science, 2020, Volume: 40, Issue:2

    Topics: Animals; Cardiomyopathies; Disease Models, Animal; Down-Regulation; Fibrosis; Gene Expression Regula

2020
Investigation on protective effect of Terminalia bellirica (Roxb.) against drugs induced cardiotoxicity in wistar albino rats.
    Journal of ethnopharmacology, 2020, Oct-28, Volume: 261

    Topics: Animals; Biomarkers; Cardiomyopathies; Cardiotoxicity; Disease Models, Animal; Doxorubicin; Fruit; I

2020
Matrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice.
    Acta pharmacologica Sinica, 2021, Volume: 42, Issue:4

    Topics: Alkaloids; Animals; Cardiomyopathies; Cardiotonic Agents; Cell Movement; Cell Proliferation; Cell Tr

2021
Si-Miao-Yong-An Decoction attenuates isoprenaline-induced myocardial fibrosis in AMPK-driven Akt/mTOR and TGF-β/SMAD3 pathways.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 130

    Topics: Adrenergic beta-Agonists; Animals; Cardiomyopathies; Collagen; Drugs, Chinese Herbal; Echocardiograp

2020
Erdosteine salvages cardiac necrosis: Novel effect through modulation of MAPK and Nrf-2/HO-1 pathway.
    Journal of biochemical and molecular toxicology, 2020, Volume: 34, Issue:12

    Topics: Animals; Biomarkers; Cardiomyopathies; Cytokines; Dose-Response Relationship, Drug; Heme Oxygenase (

2020
Blunted beta-adrenoceptor-mediated inotropy in valvular cardiomyopathy: another piece of the puzzle in human aortic valve disease.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2021, 07-14, Volume: 60, Issue:1

    Topics: Aortic Valve; Aortic Valve Disease; Aortic Valve Insufficiency; Cardiomyopathies; Humans; Isoprotere

2021
Periplocymarin protects against myocardial fibrosis induced by β-adrenergic activation in mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 139

    Topics: Adrenergic beta-Agonists; Animals; Cardiac Glycosides; Cardiomyopathies; Cyclooxygenase 2; Echocardi

2021
Cardioprotective effect of nicorandil on isoproterenol induced cardiomyopathy in the Mdx mouse model.
    BMC cardiovascular disorders, 2021, 06-15, Volume: 21, Issue:1

    Topics: Animals; Cardiomyopathies; Disease Models, Animal; Female; Fibrosis; Isoproterenol; Mice, Inbred mdx

2021
Myocardial connexin-43 is upregulated in response to acute cardiac injury in rats.
    Canadian journal of physiology and pharmacology, 2017, Volume: 95, Issue:8

    Topics: Animals; Cardiomyopathies; Connexin 43; Extracellular Space; Isoproterenol; Male; Matrix Metalloprot

2017
Shikonin ameliorates isoproterenol (ISO)-induced myocardial damage through suppressing fibrosis, inflammation, apoptosis and ER stress.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 93

    Topics: Animals; Apoptosis; Cardiomyopathies; Caspase 3; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Re

2017
Increased CD11b+ cells and Interleukin-1 (IL-1) alpha levels during cardiomyopathy induced by chronic adrenergic activation.
    The Israel Medical Association journal : IMAJ, 2017, Volume: 19, Issue:9

    Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Cardiomyopathies; CD11b Antigen; Interleukin-1alpha

2017
Protective and therapeutic effects of dexpanthenol on isoproterenol-induced cardiac damage in rats.
    Journal of cellular biochemistry, 2018, Volume: 119, Issue:9

    Topics: Animals; Antioxidants; Cardiomyopathies; Catalase; Glutathione; Glutathione Peroxidase; Isoprotereno

2018
Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis.
    Circulation, 2018, 09-18, Volume: 138, Issue:12

    Topics: Animals; Cardiomyopathies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Fibr

2018
Fasting/Refeeding Cycles Prevent Myocardial Dysfunction and Morphology Damage in the Spontaneously Hypertensive Rats.
    Arquivos brasileiros de cardiologia, 2018, Volume: 111, Issue:3

    Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Calcium; Caloric Restriction; Card

2018
Immunohistochemical characterization of myofibroblasts appearing in isoproterenol-induced rat myocardial fibrosis.
    The Journal of veterinary medical science, 2019, Jan-25, Volume: 81, Issue:1

    Topics: Adrenergic beta-Agonists; Animals; Cardiomyopathies; Endomyocardial Fibrosis; Gene Expression Regula

2019
Protective role of Gentianella acuta on isoprenaline induced myocardial fibrosis in rats via inhibition of NF-κB pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 110

    Topics: Animals; Cardiomyopathies; Cardiotonic Agents; Dose-Response Relationship, Drug; Gentianella; Isopro

2019
Acute AT
    Journal of molecular and cellular cardiology, 2019, Volume: 128

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Cardiomyopathies; Dystrophin; Heart; Humans; Isopr

2019
Stevioside attenuates isoproterenol-induced mouse myocardial fibrosis through inhibition of the myocardial NF-κB/TGF-β1/Smad signaling pathway.
    Food & function, 2019, Feb-20, Volume: 10, Issue:2

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cardiomyopathies; Cell Line; Diterpene

2019
Chrysophanol attenuated isoproterenol-induced cardiac hypertrophy by inhibiting Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway.
    Cell biology international, 2019, Volume: 43, Issue:6

    Topics: Animals; Animals, Newborn; Anthraquinones; Cardiomegaly; Cardiomyopathies; Isoproterenol; Janus Kina

2019
Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Volume: 58

    Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Cardiomyopat

2019
The potential role of neddylation in pre- and postnatal cardiac remodeling.
    American journal of physiology. Heart and circulatory physiology, 2019, Aug-01, Volume: 317, Issue:2

    Topics: Cardiomyopathies; Heart Failure; Humans; Infant, Newborn; Isoproterenol; Signal Transduction; Ventri

2019
Cardioprotective effect of ritonavir, an antiviral drug, in isoproterenol induced myocardial necrosis: a new therapeutic implication.
    Journal of translational medicine, 2013, Mar-26, Volume: 11

    Topics: Animals; Antioxidants; Body Weight; Cardiomyopathies; Cardiotonic Agents; Glucose Transporter Type 4

2013
Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway.
    Circulation, 2013, Apr-23, Volume: 127, Issue:16

    Topics: Adenylyl Cyclases; Animals; Cardiomyopathies; Crosses, Genetic; Cyclic N-Oxides; Enzyme Induction; F

2013
Interleukin-1β induces a reversible cardiomyopathy in the mouse.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2013, Volume: 62, Issue:7

    Topics: Adrenergic beta-Agonists; Animals; Cardiomyopathies; Interleukin-1beta; Isoproterenol; Male; Mice; M

2013
The role of sulfur dioxide in the regulation of mitochondrion-related cardiomyocyte apoptosis in rats with isopropylarterenol-induced myocardial injury.
    International journal of molecular sciences, 2013, May-21, Volume: 14, Issue:5

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cardiomyopathies; Caspase 3; Casp

2013
N-acetylcysteine reverses cardiac myocyte dysfunction in a rodent model of behavioral stress.
    Journal of applied physiology (Bethesda, Md. : 1985), 2013, Aug-15, Volume: 115, Issue:4

    Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Calcium; Calcium Signaling; Cardiomyopathies; Catal

2013
Increased beta2-adrenoceptors in doxorubicin-induced cardiomyopathy in rat.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Adrenergic beta-Antagonists; Animals; Cardiomyopathies; Cardiotonic Agents; Colforsin; Doxorubicin;

2013
Autonomic modulation of repolarization instability in patients with heart failure prone to ventricular tachycardia.
    American journal of physiology. Heart and circulatory physiology, 2013, Oct-15, Volume: 305, Issue:8

    Topics: Adolescent; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Agonists; Adult; Aged; Autonomic

2013
Citrus medica "Otroj": attenuates oxidative stress and cardiac dysrhythmia in isoproterenol-induced cardiomyopathy in rats.
    Nutrients, 2013, Oct-28, Volume: 5, Issue:11

    Topics: Animals; Antioxidants; Biomarkers; Biphenyl Compounds; Cardiomyopathies; Citrus; Female; Flavonoids;

2013
miR-208a as a biomarker of isoproterenol-induced cardiac injury in Sod2+/- and C57BL/6J wild-type mice.
    Toxicologic pathology, 2014, Volume: 42, Issue:7

    Topics: Animals; Biomarkers; Cardiac Myosins; Cardiomyopathies; Caspase 3; Female; Heart; Isoproterenol; Mal

2014
Apocynin attenuates isoproterenol-induced myocardial injury and fibrogenesis.
    Biochemical and biophysical research communications, 2014, Jun-20, Volume: 449, Issue:1

    Topics: Acetophenones; Animals; Antioxidants; Cardiomyopathies; Female; Fibrosis; Humans; Isoproterenol; Mal

2014
Danshensu inhibits β-adrenergic receptors-mediated cardiac fibrosis by ROS/p38 MAPK axis.
    Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:6

    Topics: Adrenergic beta-Agonists; Animals; Cardiomyopathies; Cell Proliferation; Cells, Cultured; Collagen T

2014
Disruption of type 5 adenylyl cyclase prevents β-adrenergic receptor cardiomyopathy: a novel approach to β-adrenergic receptor blockade.
    American journal of physiology. Heart and circulatory physiology, 2014, Nov-15, Volume: 307, Issue:10

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Apoptosis; Cardiomyopathies; Cell Size; Diseas

2014
The Huntington's disease-related cardiomyopathy prevents a hypertrophic response in the R6/2 mouse model.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Adrenergic beta-Antagonists; Animals; Brain-Derived Neurotrophic Factor; Cardiomyopathies; Collagen

2014
Assessment of Indian Rosewood (Dalbergia sissoo) Standardized Leaf Extract on Isoproterenol-Induced Myocardial Injury in Rats.
    Cardiovascular toxicology, 2015, Volume: 15, Issue:3

    Topics: Animals; Cardiomyopathies; Cardiotonic Agents; Dalbergia; Isoproterenol; Male; Myocardium; Oxidative

2015
Impaired oxidative metabolism and calcium mishandling underlie cardiac dysfunction in a rat model of post-acute isoproterenol-induced cardiomyopathy.
    American journal of physiology. Heart and circulatory physiology, 2015, Mar-01, Volume: 308, Issue:5

    Topics: Adrenergic Agonists; Animals; Calcium Signaling; Calcium-Binding Proteins; Cardiomyopathies; Cells,

2015
Combined Effects of Vincristine and Quercetin in Reducing Isoproterenol-Induced Cardiac Necrosis in Rats.
    Cardiovascular toxicology, 2015, Volume: 15, Issue:4

    Topics: Animals; Antioxidants; Biomarkers; Cardiomyopathies; Cytoprotection; Disease Models, Animal; Drug Th

2015
Cardiomyopathy confers susceptibility to particulate matter-induced oxidative stress, vagal dominance, arrhythmia and pulmonary inflammation in heart failure-prone rats.
    Inhalation toxicology, 2015, Volume: 27, Issue:2

    Topics: Administration, Inhalation; Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Cardiomyopathie

2015
Mst1 inhibition rescues β1-adrenergic cardiomyopathy by reducing myocyte necrosis and non-myocyte apoptosis rather than myocyte apoptosis.
    Basic research in cardiology, 2015, Volume: 110, Issue:2

    Topics: Adrenergic beta-1 Receptor Agonists; Animals; Blotting, Western; Cardiomyopathies; Disease Models, A

2015
Autologous c-Kit+ Mesenchymal Stem Cell Injections Provide Superior Therapeutic Benefit as Compared to c-Kit+ Cardiac-Derived Stem Cells in a Feline Model of Isoproterenol-Induced Cardiomyopathy.
    Clinical and translational science, 2015, Volume: 8, Issue:5

    Topics: Animals; Biomarkers; Cardiomyopathies; Cats; Cell Proliferation; Cells, Cultured; Disease Models, An

2015
l-Arginine Attenuates Cardiac Dysfunction, But Further Down-Regulates α-Myosin Heavy Chain Expression in Isoproterenol-Induced Cardiomyopathy.
    Basic & clinical pharmacology & toxicology, 2015, Volume: 117, Issue:4

    Topics: Amidohydrolases; Animals; Arginine; Cardiomyopathies; Cardiotonic Agents; Disease Models, Animal; Do

2015
Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy.
    Journal of molecular and cellular cardiology, 2015, Volume: 84

    Topics: Adipose Tissue, Brown; Animals; Biomarkers; Blood Pressure; Body Weight; Cardiomyopathies; Cardioton

2015
CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic β-adrenergic stimulation.
    Journal of molecular and cellular cardiology, 2015, Volume: 85

    Topics: Adrenergic beta-Agonists; Animals; Calcium; Calcium Signaling; Calcium-Binding Proteins; Calcium-Cal

2015
Roles of heat shock factor 1 in isoproterenol‑induced myocardial fibrosis in mice.
    Molecular medicine reports, 2015, Volume: 12, Issue:4

    Topics: Animals; Cardiomyopathies; Collagen; Disease Models, Animal; DNA-Binding Proteins; Fibrosis; Gene Ex

2015
Cardiac effects of long-term active immunization with the second extracellular loop of human β1- and/or β3-adrenoceptors in Lewis rats.
    Pharmacological research, 2015, Volume: 100

    Topics: Animals; Cardiomyopathies; Humans; Isoproterenol; Male; Myocardial Contraction; Myocytes, Cardiac; P

2015
Relaxin inhibits cardiac fibrosis and endothelial-mesenchymal transition via the Notch pathway.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Animals; Cardiomyopathies; Cell Movement; Cells, Cultured; Collagen; Dipeptides; Disease Models, Ani

2015
Insulin-like growth factor 1 prevents diastolic and systolic dysfunction associated with cardiomyopathy and preserves adrenergic sensitivity.
    Acta physiologica (Oxford, England), 2016, Volume: 216, Issue:4

    Topics: Animals; Cardiomyopathies; Cardiotonic Agents; Chromatography, High Pressure Liquid; Disease Models,

2016
[Effect of edaravone on oxidative stress and myocardial fibrosis induced by isoproterenol in rats].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2015, Volume: 35, Issue:11

    Topics: Animals; Antipyrine; Cardiomyopathies; Collagen; Disease Models, Animal; Drugs, Chinese Herbal; Edar

2015
Bone marrow mesenchymal stromal cells with CD47 high expression via the signal transducer and activators of transcription signaling pathway preventing myocardial fibrosis.
    International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:9

    Topics: Animals; Antibodies, Bispecific; Cardiomyopathies; CD47 Antigen; Cells, Cultured; Collagen; Disease

2015
Renal Denervation Findings on Cardiac and Renal Fibrosis in Rats with Isoproterenol Induced Cardiomyopathy.
    Scientific reports, 2015, Dec-22, Volume: 5

    Topics: Angiotensin II; Animals; Biomarkers; Cardiomyopathies; Cytokines; Denervation; Fibrosis; Heart Atria

2015
Sarcospan Regulates Cardiac Isoproterenol Response and Prevents Duchenne Muscular Dystrophy-Associated Cardiomyopathy.
    Journal of the American Heart Association, 2015, Dec-23, Volume: 4, Issue:12

    Topics: Animals; Cardiomyopathies; Carrier Proteins; Creatine Kinase, MB Form; Echocardiography; Fluorescent

2015
'Ajwa' dates (Phoenix dactylifera L.) extract ameliorates isoproterenol-induced cardiomyopathy through downregulation of oxidative, inflammatory and apoptotic molecules in rodent model.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, Oct-15, Volume: 23, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cardiomyopathies; Cardiotonic Agents; Do

2016
A Moderate Carnitine Deficiency Exacerbates Isoproterenol-Induced Myocardial Injury in Rats.
    Cardiovascular drugs and therapy, 2016, Volume: 30, Issue:2

    Topics: Animals; Cardiomyopathies; Carnitine; Diastole; Heart; Heart Diseases; Heart Rate; Hyperammonemia; I

2016
Paricalcitol Attenuates Cardiac Fibrosis and Expression of Endothelial Cell Transition Markers in Isoproterenol-Induced Cardiomyopathic Rats.
    Critical care medicine, 2016, Volume: 44, Issue:9

    Topics: Actins; Animals; Cardiomyopathies; Disease Models, Animal; Endothelial Cells; Epithelial-Mesenchymal

2016
Contribution of mammalian target of rapamycin in the pathophysiology of cirrhotic cardiomyopathy.
    World journal of gastroenterology, 2016, May-21, Volume: 22, Issue:19

    Topics: Action Potentials; Animals; Carbon Tetrachloride; Cardiomyopathies; Cardiotonic Agents; Chemical and

2016
Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice.
    Cell systems, 2017, 01-25, Volume: 4, Issue:1

    Topics: ADAMTS Proteins; Animals; Cardiomegaly; Cardiomyopathies; Cardiotonic Agents; Catecholamines; Gene E

2017
The Role of Reactive Oxygen Species in β-Adrenergic Signaling in Cardiomyocytes from Mice with the Metabolic Syndrome.
    PloS one, 2016, Volume: 11, Issue:12

    Topics: Adrenergic beta-Agonists; Animals; Calcium; Cardiomyopathies; Diet, High-Fat; Electric Stimulation;

2016
Nutraceutical inherent of Spinacia oleracea Linn. methanolic leaf extract ameliorates isoproterenol induced myocardial necrosis in male albino Wistar rats via mitigating inflammation.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 85

    Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cardiomyopathies; Chromatography, High Pressure Liquid

2017
Luteolin-7-diglucuronide attenuates isoproterenol-induced myocardial injury and fibrosis in mice.
    Acta pharmacologica Sinica, 2017, Volume: 38, Issue:3

    Topics: Animals; Antioxidants; Cardiomyopathies; Cardiotonic Agents; Extracellular Matrix Proteins; Fibrosis

2017
Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum cardiomyopathy.
    European heart journal, 2017, 02-01, Volume: 38, Issue:5

    Topics: Adrenergic beta-1 Receptor Agonists; Adult; Animals; Blood Glucose; Cardiomyopathies; Dobutamine; Fe

2017
The antihypertensive chromogranin a peptide catestatin acts as a novel endocrine/paracrine modulator of cardiac inotropism and lusitropism.
    Endocrinology, 2008, Volume: 149, Issue:10

    Topics: Animals; Antihypertensive Agents; Cardiomyopathies; Cardiotonic Agents; Chromogranin A; Coronary Cir

2008
Granulocyte-colony stimulating factor increases donor mesenchymal stem cells in bone marrow and their mobilization into peripheral circulation but does not repair dystrophic heart after bone marrow transplantation.
    Circulation journal : official journal of the Japanese Circulation Society, 2008, Volume: 72, Issue:8

    Topics: Adrenergic beta-Agonists; Animals; Bone Marrow Transplantation; Cardiomyopathies; Cell Differentiati

2008
Preservation of the positive lusitropic effect of beta-adrenoceptors stimulation in diabetic cardiomyopathy.
    Anesthesia and analgesia, 2008, Volume: 107, Issue:4

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiomyopathies; Colforsin; Diabete

2008
Isoproterenol induces primary loss of dystrophin in rat hearts: correlation with myocardial injury.
    International journal of experimental pathology, 2008, Volume: 89, Issue:5

    Topics: Actins; Adrenergic beta-Agonists; Animals; Apoptosis; Cardiomyopathies; Dystroglycans; Dystrophin; E

2008
An abnormal gene expression of the beta-adrenergic system contributes to the pathogenesis of cardiomyopathy in cirrhotic rats.
    Hepatology (Baltimore, Md.), 2008, Volume: 48, Issue:6

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Carbon Tetrachloride; Cardiomyopathies; Cyclic

2008
[Expression and implication of angiotensin II type 1 receptor in myocardial fibrosis of rats].
    Zhonghua bing li xue za zhi = Chinese journal of pathology, 2008, Volume: 37, Issue:10

    Topics: Animals; Aspartate Aminotransferases; Cardiomyopathies; Cell Differentiation; Creatine Kinase; Fibro

2008
p38 MAP kinase inhibitor reverses stress-induced myocardial dysfunction in vivo.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 106, Issue:4

    Topics: Adrenergic beta-Agonists; Anesthesia; Animals; Cardiomyopathies; Dose-Response Relationship, Drug; E

2009
Antioxidant effects of a Rhodobryum roseum extract and its active components in isoproterenol-induced myocardial injury in rats and cardiac myocytes against oxidative stress-triggered damage.
    Die Pharmazie, 2009, Volume: 64, Issue:1

    Topics: Adrenergic beta-Agonists; Animals; Animals, Newborn; Antioxidants; Aspartate Aminotransferases; Bryo

2009
Antioxidants but not doxycycline treatments restore depressed beta-adrenergic responses of the heart in diabetic rats.
    Cardiovascular toxicology, 2009, Volume: 9, Issue:1

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Antioxidants; Cardiomyopathies; Diabetes Melli

2009
Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain.
    European journal of heart failure, 2009, Volume: 11, Issue:7

    Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Cardiomyopathies; Disease Models, Animal; Isoproter

2009
Characteristics of troponins as myocardial damage biomarkers in cynomolgus monkeys.
    The Journal of toxicological sciences, 2009, Volume: 34, Issue:6

    Topics: Animals; Biomarkers; Cardiomyopathies; Isoproterenol; Macaca fascicularis; Male; Myocardium; Necrosi

2009
Particulate matter inhalation exacerbates cardiopulmonary injury in a rat model of isoproterenol-induced cardiomyopathy.
    Inhalation toxicology, 2010, Volume: 22, Issue:5

    Topics: Adrenergic beta-Agonists; Air Pollutants; Animals; Cardiomyopathies; Disease Models, Animal; Drug Sy

2010
Identification of potential genomic biomarkers for early detection of chemically induced cardiotoxicity in rats.
    Toxicology, 2010, Apr-30, Volume: 271, Issue:1-2

    Topics: Animals; Antigens, Neoplasm; Biomarkers; Biomarkers, Tumor; Carbofuran; Cardiomyopathies; Cardiotoxi

2010
Effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats.
    European journal of pharmacology, 2010, Jun-25, Volume: 636, Issue:1-3

    Topics: Animals; Cardiomyopathies; Catalase; Creatine Kinase; Ginsenosides; Heart; Heart Injuries; Heart Ven

2010
Exercise training inhibits inflammatory cytokines and more than prevents myocardial dysfunction in rats with sustained beta-adrenergic hyperactivity.
    The Journal of physiology, 2010, Jul-01, Volume: 588, Issue:Pt 13

    Topics: Adrenergic beta-Agonists; Animals; Blotting, Western; Cardiomegaly; Cardiomyopathies; Cardiotonic Ag

2010
Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Jul-20, Volume: 107, Issue:29

    Topics: Aging; Animals; Calcium; Cardiomyopathies; Cyclic AMP-Dependent Protein Kinases; Death, Sudden; Fibr

2010
Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats.
    Laboratory investigation; a journal of technical methods and pathology, 2011, Volume: 91, Issue:1

    Topics: Animals; Antioxidants; Aspartate Aminotransferases; Cardiomyopathies; Gene Expression; Glutathione P

2011
Repair of the injured adult heart involves new myocytes potentially derived from resident cardiac stem cells.
    Circulation research, 2011, May-13, Volume: 108, Issue:10

    Topics: Age Factors; Animals; Cardiomyopathies; Cats; Cell Differentiation; Isoproterenol; Myocytes, Cardiac

2011
Effect of 20(S)-protopanaxatriol and its epimeric derivatives on myocardial injury induced by isoproterenol.
    Arzneimittel-Forschung, 2011, Volume: 61, Issue:3

    Topics: Adrenergic beta-Agonists; Animals; Antioxidants; Cardiomyopathies; Creatine Kinase; Glutathione Pero

2011
Myocardial structural, contractile and electrophysiological changes in the guinea-pig heart failure model induced by chronic sympathetic activation.
    Experimental physiology, 2011, Volume: 96, Issue:7

    Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Cardiomyopathies; Disease Models, Animal; Guin

2011
Membrane sealant Poloxamer P188 protects against isoproterenol induced cardiomyopathy in dystrophin deficient mice.
    BMC cardiovascular disorders, 2011, May-16, Volume: 11

    Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Aortic Valve; Blood Pressure; Body Weight;

2011
Isoproterenol-induced cardiomyopathy in rats: influence of Acorus calamus Linn.: A. calamus attenuates cardiomyopathy.
    Cardiovascular toxicology, 2011, Volume: 11, Issue:3

    Topics: Acorus; Amlodipine; Animals; Antioxidants; Calcineurin; Cardiomyopathies; Catalase; Disease Models,

2011
Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice.
    Circulation, 2011, Aug-02, Volume: 124, Issue:5

    Topics: Animals; Cardiac Imaging Techniques; Cardiomyopathies; Cardiotonic Agents; Disease Models, Animal; D

2011
Dietary salt exacerbates isoproterenol-induced cardiomyopathy in rats.
    Toxicologic pathology, 2011, Volume: 39, Issue:6

    Topics: Animals; Atrial Natriuretic Factor; Biomarkers; Bronchoalveolar Lavage Fluid; Cardiomyopathies; Fibr

2011
Puerarin prevents isoprenaline-induced myocardial fibrosis in mice by reduction of myocardial TGF-β1 expression.
    The Journal of nutritional biochemistry, 2012, Volume: 23, Issue:9

    Topics: Animals; Biological Products; Cardiomyopathies; Cardiotonic Agents; Collagen; Disease Models, Animal

2012
Heart-type fatty acid-binding protein and its relation with morphological changes in rat myocardial damage model induced by isoproterenol.
    Bosnian journal of basic medical sciences, 2011, Volume: 11, Issue:4

    Topics: Animals; Biomarkers; Cardiomyopathies; Disease Models, Animal; Fatty Acid Binding Protein 3; Fatty A

2011
Focal initiation of sustained and nonsustained ventricular tachycardia in a canine model of ischemic cardiomyopathy.
    Journal of cardiovascular electrophysiology, 2012, Volume: 23, Issue:5

    Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Cardiac Pacing, Artificial; Cardiomyopathies;

2012
Sympathetic stimulation increases dispersion of repolarization in humans with myocardial infarction.
    American journal of physiology. Heart and circulatory physiology, 2012, May-01, Volume: 302, Issue:9

    Topics: Action Potentials; Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Cardiomyopathies; Catheter Abl

2012
Alternating RBBB and LBBB post-AV node ablation: what is the mechanism?
    Pacing and clinical electrophysiology : PACE, 2012, Volume: 35, Issue:12

    Topics: Adrenergic beta-Agonists; Atrial Fibrillation; Atrioventricular Node; Bundle-Branch Block; Cardiomyo

2012
[Effects of Sini decoction on the expressions of Smad2 and Smad7 in isoproterenol induced myocardial fibrosis rats].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2012, Volume: 32, Issue:7

    Topics: Animals; Cardiomyopathies; Drugs, Chinese Herbal; Fibrosis; Isoproterenol; Male; Myocardium; Rats; R

2012
Copper enhances isoproterenol toxicity in isolated rat cardiomyocytes: effects on oxidative stress.
    Cardiovascular toxicology, 2001, Volume: 1, Issue:3

    Topics: Adrenergic beta-Agonists; Animals; Antioxidants; Cardiomyopathies; Cell Separation; Cell Survival; C

2001
[Experimental study of protective effect of tongxinluo capsule on isoproterenol induced myocardial injury in rats].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2001, Volume: 21, Issue:1

    Topics: Animals; Apoptosis; Capsules; Cardiomyopathies; Drug Combinations; Drugs, Chinese Herbal; Isoprotere

2001
The effect of breed, age, and sex on myocardial necrosis produced by isoproterenol in the rat.
    Journal of gerontology, 1959, Volume: 14, Issue:2

    Topics: Aging; Animals; Cardiomyopathies; Disease; Heart Diseases; Isoproterenol; Myocardial Infarction; Myo

1959
MUSCULAR SUBAORTIC STENOSIS; THE INTERRELATION OF WALL TENSION, OUTFLOW TRACT "DISTENDING PRESSURE" AND ORIFICE RADIUS.
    The American journal of cardiology, 1965, Volume: 15

    Topics: Amyl Nitrite; Angiotensins; Blood Pressure; Cardiac Catheterization; Cardiac Surgical Procedures; Ca

1965
EFFECT OF LEFT VENTRICULAR SIZE AND SHAPE UPON THE HEMODYNAMICS OF SUBAORTIC STENOSIS.
    The American journal of cardiology, 1965, Volume: 15

    Topics: Angiocardiography; Blood Pressure; Cardiac Catheterization; Cardiomyopathies; Cardiomyopathy, Hypert

1965
Potassium canrenoate, an aldosterone receptor antagonist, reduces isoprenaline-induced cardiac fibrosis in the rat.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:3

    Topics: Animals; Blood Pressure; Canrenoic Acid; Cardiomyopathies; Disease Models, Animal; Dose-Response Rel

2004
Regression of dietary copper restriction-induced cardiomyopathy by copper repletion in mice.
    The Journal of nutrition, 2004, Volume: 134, Issue:4

    Topics: Adrenergic beta-Agonists; Animals; Cardiomyopathies; Copper; Diet; Female; Heart Rate; Isoproterenol

2004
Full-length dystrophin expression in half of the heart cells ameliorates beta-isoproterenol-induced cardiomyopathy in mdx mice.
    Human molecular genetics, 2004, Aug-01, Volume: 13, Issue:15

    Topics: Animals; Cardiomyopathies; Cardiotonic Agents; Dystrophin; Female; Genetic Therapy; Heterozygote; Is

2004
Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress.
    Nature medicine, 2004, Volume: 10, Issue:12

    Topics: Adrenergic beta-Agonists; Animals; beta-Galactosidase; Biomechanical Phenomena; Calcineurin; Calcine

2004
Abnormal Ca(2+) release and catecholamine-induced arrhythmias in mitochondrial cardiomyopathy.
    Human molecular genetics, 2005, Apr-15, Volume: 14, Issue:8

    Topics: Adrenergic beta-Agonists; Animals; Arrhythmias, Cardiac; Calcium; Cardiomyopathies; Catecholamines;

2005
Sildenafil citrate increases myocardial cGMP content in rat heart, decreases its hypertrophic response to isoproterenol and decreases myocardial leak of creatine kinase and troponin T.
    BMC pharmacology, 2005, Apr-06, Volume: 5

    Topics: Adrenergic beta-Agonists; Animals; Cardiomyopathies; Creatine Kinase; Guanosine Monophosphate; Isopr

2005
Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 289, Issue:2

    Topics: Adrenergic beta-Agonists; Animals; Atrial Natriuretic Factor; Calcium; Calcium-Binding Proteins; Cal

2005
The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity.
    Cardiovascular research, 2006, Volume: 69, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; Cardiomyopathies; Cardiotonic Agents; Cytoplasm; Doxorubicin;

2006
Contribution of endogenous opioids and nitric oxide to papillary muscle contractile impairment in cholestatic rats.
    European journal of pharmacology, 2005, Oct-31, Volume: 523, Issue:1-3

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Analysis of Variance; Animals; Bile Ducts; Card

2005
Trimetazidine improved Ca2+ handling in isoprenaline-mediated myocardial injury of rats.
    Experimental physiology, 2006, Volume: 91, Issue:3

    Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Signaling; Cardiomyopathies; Cardiotonic Agents; D

2006
Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling.
    Circulation research, 2006, Oct-27, Volume: 99, Issue:9

    Topics: Adrenergic beta-Agonists; Animals; beta-Adrenergic Receptor Kinases; Cardiomyopathies; Cardiotonic A

2006
Serum cardiac troponin T as a biomarker for acute myocardial injury induced by low doses of isoproterenol in rats.
    Cardiovascular toxicology, 2006, Volume: 6, Issue:3-4

    Topics: Acute Disease; Adrenergic beta-Agonists; Animals; Biomarkers; Cardiomyopathies; Dose-Response Relati

2006
Beta-, not alpha-adrenergic stimulation enhances conduction velocity in cultures of neonatal cardiomyocytes.
    Circulation journal : official journal of the Japanese Circulation Society, 2007, Volume: 71, Issue:6

    Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Animals, Newborn; C

2007
Cardioprotective effect of ocotillol, a derivate of pseudoginsenoside F11, on myocardial injury induced by isoproterenol in rats.
    Arzneimittel-Forschung, 2007, Volume: 57, Issue:9

    Topics: Adrenergic beta-Agonists; Animals; Antioxidants; Biomarkers; Cardiomyopathies; Cardiotonic Agents; G

2007
Grape seed proanthocyanidins ameliorates isoproterenol-induced myocardial injury in rats by stabilizing mitochondrial and lysosomal enzymes: an in vivo study.
    Life sciences, 2007, Nov-30, Volume: 81, Issue:23-24

    Topics: Adrenergic beta-Agonists; Animals; Cardiomyopathies; Cardiotonic Agents; Electron Transport; Isoprot

2007
Cardioprotective effects of Astragali Radix against isoproterenol-induced myocardial injury in rats and its possible mechanism.
    Phytotherapy research : PTR, 2008, Volume: 22, Issue:3

    Topics: Animals; Astragalus Plant; Cardiomegaly; Cardiomyopathies; Cardiotonic Agents; Carrier Proteins; Cyc

2008
Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification.
    Circulation research, 2008, May-09, Volume: 102, Issue:9

    Topics: Adrenergic beta-Agonists; Animals; Calcinosis; Calcium-Binding Proteins; Cardiomyopathies; Cell Adhe

2008
Responses to drug-induced myocardial necrosis in rats with various degrees of arteriosclerosis.
    Circulation research, 1967, Volume: 20, Issue:1

    Topics: Adrenal Glands; Animals; Arteriosclerosis; Blood Circulation; Cardiomyopathies; Cholesterol; Coronar

1967
Cardiomyopathies.
    Science (New York, N.Y.), 1967, Jun-23, Volume: 156, Issue:3782

    Topics: Brain Diseases; Cardiomyopathies; Electrolytes; Isoproterenol; Myocardial Infarction; Myocarditis; N

1967
Effects of prompt squatting on the systolic murmur in idiopathic hypertrophic obstructive cardiomyopathy.
    British medical journal, 1967, Jul-15, Volume: 3, Issue:5558

    Topics: Adolescent; Adult; Aged; Amyl Nitrite; Aortic Valve Stenosis; Blood Pressure; Cardiomyopathies; Chil

1967
Muscular subaortic stenosis. Initial left ventricular inflow tract pressure in the assessment of intraventricular pressure differences in man.
    Circulation, 1967, Volume: 35, Issue:6

    Topics: Blood Pressure; Cardiac Catheterization; Cardiomyopathies; Cardiomyopathy, Hypertrophic; Humans; Iso

1967
[Physiology and pathology of connective tissue in heart muscle with age-related differences (so-called isoproterenol-cardiopathy of the rat) (author's transl)].
    Aktuelle Gerontologie, 1981, Volume: 11, Issue:6

    Topics: Age Factors; Animals; Aorta; Cardiomyopathies; Energy Metabolism; Hexosamines; Hydroxyproline; Isopr

1981
Right ventricular tachycardia: clinical and electrophysiologic characteristics.
    Circulation, 1983, Volume: 68, Issue:5

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Anti-Arrhythmia Agents; Bundle-Branch Block; C

1983
[Ultrastructure and metabolic heterogeneity of cardiomyocytes in acute myocardial injury during aging].
    Biulleten' eksperimental'noi biologii i meditsiny, 1982, Volume: 94, Issue:10

    Topics: Aging; Animals; Autoradiography; Cardiomyopathies; Histocytochemistry; Isoproterenol; Male; Microsco

1982
[Heart transplantation. Current status at La Pitié Hospital].
    Presse medicale (Paris, France : 1983), 1983, Nov-12, Volume: 12, Issue:40

    Topics: Cardiomyopathies; Coronary Disease; Graft Rejection; Heart Transplantation; Hemodynamics; Humans; Im

1983
Comparison of cardiac lesions induced in rats by isoproterenol and by repeated stress of restraint and water immersion with special reference to etiology of cardiomyopathy.
    Japanese circulation journal, 1980, Volume: 44, Issue:12

    Topics: Adrenal Glands; Animals; Cardiomegaly; Cardiomyopathies; Catecholamines; Heart; Immersion; Isoproter

1980
Cardiac beta adrenoceptors and adenylate cyclase in normotensive and renal hypertensive rabbits during changes in autonomic activity.
    Clinical and experimental hypertension, 1981, Volume: 3, Issue:2

    Topics: Adenosine Triphosphatases; Adenylyl Cyclases; Animals; Autonomic Nervous System; Blood Pressure; Car

1981
Electron microscopic study of cardiac lesions induced in rats by isoproterenol and by repeated stress. With suggestion that idiopathic cardiomyopathy may be a "disease of adaptation".
    Japanese circulation journal, 1981, Volume: 45, Issue:12

    Topics: Adaptation, Physiological; Animals; Cardiomyopathies; Heart; Isoproterenol; Microscopy, Electron; My

1981
Leukocyte collagenolytic activity in normal and hydrazinophthalazine-treated rats during isoprenaline-induced cardiomyopathy.
    Experimental pathology, 1983, Volume: 23, Issue:4

    Topics: Animals; Cardiomyopathies; Cathepsins; Collagen; Hydralazine; Isoproterenol; Leukocytes; Macrophages

1983
The activity of adenylate cyclase and phosphodiesterase in the isoproterenol-damaged cardiac muscle of spontaneously hypertensive rats.
    Polish journal of pharmacology and pharmacy, 1983, Volume: 35, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Cardiomyopathies; Cell Membrane; Cy

1983
[Effect of disseminated myocardial necrosis on ATPase activity, Ca2+ transport, and lipid peroxidation in cardiac mitochondrial and microsomal membranes].
    Biulleten' eksperimental'noi biologii i meditsiny, 1980, Volume: 89, Issue:5

    Topics: Adenosine Triphosphatases; Animals; Calcium; Cardiomyopathies; Dinitrophenols; Isoproterenol; Lipid

1980
The effect of pregnancy and lactation on the development of experimental heart lesions.
    Physiologia Bohemoslovaca, 1980, Volume: 29, Issue:4

    Topics: Animals; Cardiomyopathies; Female; Hypoxia; In Vitro Techniques; Isoproterenol; Lactation; Myocardia

1980
Quantitative evaluation of the development of isoprenaline-induced heart lesions.
    Physiologia Bohemoslovaca, 1980, Volume: 29, Issue:4

    Topics: Animals; Cardiomyopathies; Isoproterenol; Male; Mercury Radioisotopes; Myocardium; Rats

1980
Calcium and myocardial cell injury. An appraisal in the cardiomyopathic hamster.
    Canadian journal of physiology and pharmacology, 1984, Volume: 62, Issue:7

    Topics: Animals; Calcium; Calcium Channel Blockers; Cardiomyopathies; Cricetinae; Female; Isoproterenol; Mal

1984
Oxyfedrine and propranolol. A comparative experimental approach to protect myocardium against isoprenaline-induced myocardial necrosis.
    Arzneimittel-Forschung, 1984, Volume: 34, Issue:6

    Topics: Animals; Cardiomyopathies; Female; Glycolysis; Isoproterenol; Male; Myocardium; Necrosis; Oxyfedrine

1984
Mechanism of action of dimethyl quaternary propranolol (UM-272) in isoproterenol-induced cardiomyopathy in rats.
    The Indian journal of medical research, 1983, Volume: 77

    Topics: Animals; Anti-Arrhythmia Agents; Anura; Cardiomyopathies; Coronary Disease; Female; Isoproterenol; M

1983
Consequences of uncontrolled calcium entry and its prevention with calcium antagonists.
    European heart journal, 1983, Volume: 4 Suppl H

    Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Cardiomyopathies; Isoproterenol;

1983
Effect of hypocalcemia on isoproterenol induced cardiotoxicity in dogs.
    Angiology, 1984, Volume: 35, Issue:3

    Topics: Animals; Calcium; Cardiomyopathies; Creatine Kinase; Dogs; Electrocardiography; Heart; Hypocalcemia;

1984
Adenylate cyclase activity and localization in necrotic and non-necrotic areas of rat myocardium after injection of high doses of isoproterenol.
    Biomedica biochimica acta, 1984, Volume: 43, Issue:1

    Topics: Adenylyl Cyclases; Animals; Cardiomyopathies; Histocytochemistry; Isoproterenol; Male; Myocardium; N

1984
Growth, food intake, motor activity and experimental cardiac necrosis in early malnourished male rats.
    Annals of nutrition & metabolism, 1982, Volume: 26, Issue:2

    Topics: Aging; Animals; Cardiomyopathies; Diet; Growth; Isoproterenol; Male; Motor Activity; Myocardium; Nec

1982
Determinants of resistance to the cardiotoxicity of isoproterenol in rats.
    Toxicology and applied pharmacology, 1983, Jun-30, Volume: 69, Issue:2

    Topics: Animals; Cardiomyopathies; Drug Resistance; Drug Tolerance; Isoproterenol; Male; Necrosis; Rats; Rat

1983
Potential oxidative pathways of catecholamines in the formation of lipid peroxides and genesis of heart disease.
    Advances in experimental medicine and biology, 1983, Volume: 161

    Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Cardiomyopathies; Catecholamines; Isoproteren

1983
Effect of isoproterenol and taurine on heart calcium in normal and cardiomyopathic hamsters.
    Journal of molecular and cellular cardiology, 1982, Volume: 14, Issue:6

    Topics: Animals; Calcium; Cardiomyopathies; Cricetinae; Isoproterenol; Mesocricetus; Myocardium; Taurine

1982
Myocardial necrosis associated with isoproterenol abuse: a ten-year follow-up.
    Texas medicine, 1982, Volume: 78, Issue:8

    Topics: Adult; Cardiomyopathies; Female; Follow-Up Studies; Humans; Isoproterenol; Necrosis; Substance-Relat

1982
Role of free radicals in catecholamine-induced cardiomyopathy.
    Canadian journal of physiology and pharmacology, 1982, Volume: 60, Issue:11

    Topics: Animals; Cardiomyopathies; Catecholamines; Coronary Disease; Electrocardiography; Free Radicals; Iso

1982
Clofibrate, fibrinolysis and experimental myocardial damage.
    Journal of postgraduate medicine, 1981, Volume: 27, Issue:1

    Topics: Animals; Cardiomyopathies; Clofibrate; Fibrinolysis; Isoproterenol; Male; Rats

1981
[Severe myocardial bridge on the anterior interventricular artery. Demonstration by coronarography using isoprenaline].
    La Nouvelle presse medicale, 1981, May-09, Volume: 10, Issue:21

    Topics: Adult; Cardiomyopathies; Coronary Angiography; Coronary Disease; Humans; Isoproterenol; Male

1981
Enhanced noradrenaline response in cardiomyopathic hamsters: possible relation to changes in adrenoceptors studied by radioligand binding.
    Cardiovascular research, 1981, Volume: 15, Issue:5

    Topics: Animals; Cardiomyopathies; Cricetinae; Heart Ventricles; In Vitro Techniques; Isoproterenol; Myocard

1981
The role of calcium in the toxicity of the myocardium.
    The Histochemical journal, 1981, Volume: 13, Issue:5

    Topics: Acute Disease; Animals; Calcium; Cardiomyopathies; Chronic Disease; Coronary Disease; Daunorubicin;

1981
Experimental study on the effect of CoQ-10 administration to isoproterenol-induced cardiomyopathy of rats.
    The Kurume medical journal, 1981, Volume: 28, Issue:2

    Topics: Animals; Cardiomyopathies; Cytochromes; Isoproterenol; Lipid Peroxides; Mitochondria, Heart; Oxygen

1981
[Vitamin E (tocopherol) levels in the blood serum and myocardium of rats with myocardial micronecrosis caused by stimulation with isoprenaline].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1980, Jan-14, Volume: 35, Issue:2

    Topics: Animals; Cardiomyopathies; Isoproterenol; Male; Muscular Atrophy; Myocardium; Necrosis; Rats; Stimul

1980
[Neutralization of ammonia in cardiac muscle].
    Biulleten' eksperimental'noi biologii i meditsiny, 1980, Volume: 89, Issue:3

    Topics: Alanine; Ammonia; Animals; Aspartic Acid; Cardiomyopathies; Glutamates; Glutamine; Isoproterenol; Ma

1980
[Histometric characteristics of capillary-glio-neurocytic relationships of cervicothoracic (stellate) ganglia of cats during experimental isadrine-induced myocardial necrosis].
    Biulleten' eksperimental'noi biologii i meditsiny, 1980, Volume: 89, Issue:5

    Topics: Animals; Capillaries; Cardiomyopathies; Cats; Isoproterenol; Necrosis; Neuroglia; Stellate Ganglion

1980
Studies of hypotension and cardiac flow in isoproterenol-induced myocardial necrosis.
    Experimental and molecular pathology, 1981, Volume: 34, Issue:1

    Topics: Animals; Calcium; Cardiomyopathies; Coronary Circulation; Heart; Hypotension; Isoproterenol; Male; M

1981
Uncoupling of beta 1-adrenoceptors from cardiac adenylyl cyclase in cardiomyopathic and control hamsters.
    European journal of pharmacology, 1993, Oct-15, Volume: 247, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Binding, Compe

1993
Diagnostic efficiency of troponin T measurements in rats with experimental myocardial cell damage.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 1995, Volume: 47, Issue:2-3

    Topics: Animals; Aspartate Aminotransferases; Biomarkers; Cardiomyopathies; Creatine Kinase; Isoproterenol;

1995
Pharmacological study of isoproterenol and diabetic cardiomyopathies in rat right ventricular strips.
    Pharmacology, 1993, Volume: 46, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1993
Calcium currents in diseased human cardiac cells.
    Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:2

    Topics: Adult; Aged; Calcium; Calcium Channels; Cardiac Surgical Procedures; Cardiomyopathies; Cyclic AMP; E

1995
Bovine hereditary cardiomyopathy: an animal model of human dilated cardiomyopathy.
    Journal of molecular and cellular cardiology, 1995, Volume: 27, Issue:1

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cardiomyopathies; Cardiomyopathy, Dilated; Cate

1995
Distinct modulation of myocardial performance, energy metabolism, and [Ca2+]i transients by positive inotropic drugs in normal and severely failing hamster hearts.
    Cardiovascular drugs and therapy, 1995, Volume: 9, Issue:1

    Topics: Amrinone; Animals; Blood Pressure; Bucladesine; Calcium; Cardiomyopathies; Cardiotonic Agents; Crice

1995
Cellular and molecular alterations in the beta adrenergic system with cardiomyopathy induced by tachycardia.
    Cardiovascular research, 1994, Volume: 28, Issue:8

    Topics: Adenylyl Cyclases; Animals; Cardiomyopathies; Cell Size; Colforsin; GTP-Binding Proteins; Isoprotere

1994
Morphometry of reversible myocardial damage.
    Annals of the New York Academy of Sciences, 1994, Jun-17, Volume: 723

    Topics: Allopurinol; Animals; Cardiomyopathies; Cytoplasm; Diltiazem; Gerbillinae; Hydroxybutyrates; Isoprot

1994
Cardioprotective action of sodium gamma-hydroxybutyrate against isoproterenol induced myocardial damage.
    International journal of experimental pathology, 1993, Volume: 74, Issue:3

    Topics: Animals; Cardiomyopathies; Gerbillinae; Isoproterenol; Lipids; Male; Microscopy, Electron; Mitochond

1993
Ca2+ transients and cell shortening in diabetic rat ventricular myocytes.
    Japanese circulation journal, 1993, Volume: 57, Issue:5

    Topics: Animals; Biological Transport; Calcium; Cardiomegaly; Cardiomyopathies; Cell Size; Diabetes Mellitus

1993
Impaired regulation of cell communication by beta-adrenergic receptor activation in the failing heart.
    Hypertension (Dallas, Tex. : 1979), 1996, Volume: 27, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Cardiomyopathies;

1996
Role of altered beta-adrenoceptor signal transduction in the pathogenesis of cirrhotic cardiomyopathy in rats.
    Gastroenterology, 1996, Volume: 110, Issue:4

    Topics: Adrenergic beta-Agonists; Animals; Blotting, Western; Cardiomyopathies; Cell Membrane; Colforsin; Cy

1996
DNA resynthesis and binucleated metamorphosis in cardiac muscle cells after isoproterenol-induced injury: bromodeoxyuridine immunohistochemistry.
    The American journal of cardiovascular pathology, 1995, Volume: 5, Issue:1

    Topics: Animals; Bromodeoxyuridine; Cardiomyopathies; Cardiotonic Agents; Cell Nucleus; DNA; Immunohistochem

1995
Influence of isoproterenol and ouabain on excitation-contraction coupling, cross-bridge function, and energetics in failing human myocardium.
    Circulation, 1996, Dec-15, Volume: 94, Issue:12

    Topics: Cardiomyopathies; Energy Metabolism; Heart; Heart Failure; Heart Transplantation; Humans; In Vitro T

1996
[The effect of dithiothreitol on the ultrastructure of cardiomyocytes from the pro-oxidant heart region in rats with experimental cardiac insufficiency].
    Biulleten' eksperimental'noi biologii i meditsiny, 1997, Volume: 123, Issue:4

    Topics: Adenosine Triphosphatases; Adrenergic beta-Agonists; Animals; Cardiomyopathies; Dithiothreitol; Isop

1997
Role of Lipistat in protection against isoproterenol induced myocardial necrosis in rats: a biochemical and histopathological study.
    Indian journal of physiology and pharmacology, 1998, Volume: 42, Issue:1

    Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Cardiomyopathies; Fat Necrosis; Female; H

1998
Effect of left ventricular sphericity on the evolution of ventricular dysfunction in rats with diffuse isoproterenol-induced myocardial necrosis.
    Journal of cardiac failure, 1998, Volume: 4, Issue:1

    Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Cardiac Output; Cardiomyopathies; Disease M

1998
Differences in heart phospholipids in two inbred rat strains differing in sensitivity to the development of heart lesions.
    Physiological research, 1998, Volume: 47, Issue:2

    Topics: Animals; Cardiomyopathies; Fatty Acids; Isoproterenol; Linoleic Acid; Membrane Lipids; Myocardium; N

1998
A calcium antagonist protects against doxorubicin-induced impairment of calcium handling in neonatal rat cardiac myocytes.
    Japanese circulation journal, 1999, Volume: 63, Issue:2

    Topics: Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Calcium Signaling; Cardiomyopathies; C

1999
Contribution of head-up tilt testing and ATP testing in assessing the mechanisms of vasovagal syndrome: preliminary results and potential therapeutic implications.
    Circulation, 1999, May-11, Volume: 99, Issue:18

    Topics: Adenosine Triphosphate; Age Factors; Aged; Bradycardia; Cardiac Pacing, Artificial; Cardiomyopathies

1999
Noninvasive evaluation of cardiac dysfunction by echocardiography in streptozotocin-induced diabetic rats.
    Journal of cardiac failure, 1999, Volume: 5, Issue:4

    Topics: Animals; Cardiomyopathies; Cardiotonic Agents; Diabetes Mellitus, Experimental; Disease Models, Anim

1999
Cardiomyopathic changes in streptozotocin-induced diabetes.
    Proceedings of the Western Pharmacology Society, 1999, Volume: 42

    Topics: Adenosine Triphosphatases; Animals; Body Weight; Calcium Channel Blockers; Cardiomyopathies; Cardiot

1999
Comparison of the diagnostic value of cardiac troponin I and T determinations for detecting early myocardial damage and the relationship with histological findings after isoprenaline-induced cardiac injury in rats.
    Clinica chimica acta; international journal of clinical chemistry, 2000, Volume: 298, Issue:1-2

    Topics: Animals; Antibodies, Monoclonal; Cardiomyopathies; Creatine Kinase; Heart Diseases; Isoproterenol; K

2000
Role of heme oxygenase-carbon monoxide pathway in pathogenesis of cirrhotic cardiomyopathy in the rat.
    American journal of physiology. Gastrointestinal and liver physiology, 2001, Volume: 280, Issue:1

    Topics: Animals; Blotting, Western; Carbon Monoxide; Cardiomyopathies; Cardiotonic Agents; Cyclic GMP; DNA P

2001
Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality.
    Circulation, 2001, Feb-13, Volume: 103, Issue:6

    Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Aging; Animals; Calcium-Binding Proteins; Cardiomyop

2001
Cardiomyocyte apoptosis contributes to the development of catacholamine cardiomyopathy.
    Clinica chimica acta; international journal of clinical chemistry, 2001, Volume: 308, Issue:1-2

    Topics: Animals; Apoptosis; Biomarkers; Cardiomyopathies; Isoproterenol; Macrophages; Myocardium; Necrosis;

2001
Alterative and plastic insufficiency of cardiomyocytes: isoproterenol-induced damage to myocardium during anthracycline cardiomyopathy.
    Bulletin of experimental biology and medicine, 2001, Volume: 131, Issue:6

    Topics: Animals; Antibiotics, Antineoplastic; Cardiomyopathies; Cardiotonic Agents; Cell Death; Daunorubicin

2001
[Myocyte apoptosis in catecholamine-induced cardiomyopathy].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 2001, Volume: 76, Issue:5

    Topics: Animals; Apoptosis; Calcineurin; Cardiomyopathies; Disease Models, Animal; Isoproterenol; Male; Myoc

2001
Altered cellular calcium regulatory systems in a rat model of cirrhotic cardiomyopathy.
    Gastroenterology, 2001, Volume: 121, Issue:5

    Topics: Animals; Calcium; Calcium-Transporting ATPases; Cardiomyopathies; Colforsin; Isoproterenol; Liver Ci

2001
Disruption of inducible nitric oxide synthase improves beta-adrenergic inotropic responsiveness but not the survival of mice with cytokine-induced cardiomyopathy.
    Circulation research, 2002, May-17, Volume: 90, Issue:9

    Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Blotting, Western; Cardiomyopathies; Enzyme Induc

2002
Role of cardiovascular and ionic changes in pathogenesis and prevention of isoprenaline-induced cardiac necrosis.
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 6

    Topics: Animals; Blood Pressure; Carbon Dioxide; Cardiomyopathies; Heart Rate; Hydrogen-Ion Concentration; I

1975
Alterations in norepinephrine pattern in the damaged myocardium in the rat.
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 6

    Topics: Animals; Cardiomegaly; Cardiomyopathies; Isoproterenol; Male; Monoamine Oxidase; Myocardium; Necrosi

1975
Prevention of myocardial Ca overload and necrotization by Mg and K salts or acidosis.
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 6

    Topics: Adenosine Triphosphate; Animals; Calcium; Cardiomyopathies; Dose-Response Relationship, Drug; Hydrog

1975
Effects of a CA-antagonist (prenylamine) on isoproterenol-induced myocardial lesions in the monkey (Cebus paraguayenses). Electrocardiographic and anatomopathological findings.
    Acta cardiologica, 1979, Volume: 34, Issue:6

    Topics: Animals; Calcium; Cardiomyopathies; Cytoskeleton; Electrocardiography; Female; Haplorhini; Heart Rat

1979
[Left ventricular ejection and ejection reserve during isoproterenol infusion in hypertrophic obstructive cardiomyopathy (author's transl)].
    Zeitschrift fur Kardiologie, 1977, Volume: 66, Issue:11

    Topics: Adult; Cardiac Catheterization; Cardiomegaly; Cardiomyopathies; Female; Heart Ventricles; Hemodynami

1977
[Qualitative and quantitative histoenzymatic study on isoproterenol induced myocardial necroses in rats (author's transl)].
    Arzneimittel-Forschung, 1976, Volume: 26, Issue:5

    Topics: Animals; Cardiomyopathies; Disease Models, Animal; Electron Transport Complex IV; Isoproterenol; Mal

1976
[Cardioprotection by oral application of the calcium antagonist fendiline. Prevention of isoproterenol-induced myocardial necroses in rats (author's transl)].
    Arzneimittel-Forschung, 1976, Volume: 26, Issue:10

    Topics: Animals; Calcium; Cardiomyopathies; Electron Transport Complex IV; Isoproterenol; Male; Myocardium;

1976
Adrenocortical function in response to myocardial necrosis in exercise-trained rats.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1978, Volume: 44, Issue:1

    Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aldosterone; Animals; Body Weight; Cardiomyopathies; Co

1978
Chronic Chagas' heart block: acute hemodynamic alterations during surgically implanted internal pacemakers.
    Arquivos brasileiros de cardiologia, 1977, Volume: 30, Issue:3

    Topics: Adult; Aged; Cardiomyopathies; Chagas Disease; Chronic Disease; Electrocardiography; Female; Heart B

1977
Effect of isoproterenol on the "early repolarization" syndrome.
    American heart journal, 1979, Volume: 97, Issue:3

    Topics: Adult; Aged; Cardiomyopathies; Electrocardiography; Electrophysiology; Female; Heart; Heart Diseases

1979
The effect of a calcium antagonist (D600) on isoprenaline-induced myocardial necrosis in the rat.
    British journal of experimental pathology, 1979, Volume: 60, Issue:3

    Topics: Animals; Calcium; Cardiomyopathies; Gallopamil; Isoproterenol; Male; Myocardium; Necrosis; Rats; Ver

1979
[Changes in precordial movements in non-ischaemic heart disease patients after i.v. administration of isoproterenol and dopamine. Comparison between normal and cardiopathic subjects (author's transl)].
    Giornale italiano di cardiologia, 1979, Volume: 9, Issue:6

    Topics: Adolescent; Adult; Cardiomyopathies; Child; Dopamine; Electrocardiography; Female; Heart Diseases; H

1979
On significance of plasma fibrinogen level to assess severity of myocardial damage--an experimental study.
    Indian journal of experimental biology, 1979, Volume: 17, Issue:6

    Topics: Animals; Cardiomyopathies; Female; Fibrinogen; Isoproterenol; Male; Myocardial Infarction; Myocardiu

1979
Quantitation of isoproterenol-induced myocardial necrosis with 3H-tetracycline.
    Research communications in chemical pathology and pharmacology, 1979, Volume: 25, Issue:3

    Topics: Animals; Cardiomyopathies; Dose-Response Relationship, Drug; Isoproterenol; Male; Myocardium; Necros

1979
Mineralocorticoid potentiation of isoproterenol-induced myocardial injury: Ultrastructural equivalent.
    Journal of molecular and cellular cardiology, 1979, Volume: 11, Issue:10

    Topics: Animals; Cardiomyopathies; Desoxycorticosterone; Drug Synergism; Heart; Isoproterenol; Male; Microsc

1979
An experimental investigation to correlate changes in plasma fibrinolytic activity with isoprenaline induced myocardial damage.
    Journal of postgraduate medicine, 1979, Volume: 25, Issue:3

    Topics: Animals; Blood Coagulation Tests; Cardiomyopathies; Female; Fibrinolysis; Heart; Isoproterenol; Male

1979
[The phonocardiogram in the cardiomyopathies (author's transl)].
    Giornale italiano di cardiologia, 1978, Volume: 8, Issue:2

    Topics: Adult; Amyl Nitrite; Cardiomyopathies; Cardiomyopathy, Hypertrophic; Carotid Arteries; Female; Human

1978
Cardiac glutathione: diurnal rhythm and variation in drug-induced cardiomyopathy.
    Research communications in chemical pathology and pharmacology, 1979, Volume: 24, Issue:1

    Topics: Animals; Cardiomyopathies; Circadian Rhythm; Doxorubicin; Glutathione; Isoproterenol; Liver; Male; M

1979
The prevention by creatinol O-phosphate of myocardial lesions evoked by isoprenaline.
    Archives internationales de pharmacodynamie et de therapie, 1979, Volume: 237, Issue:2

    Topics: Animals; Cardiomyopathies; Creatine; Female; Ions; Isoproterenol; Myocardium; Necrosis; Rats; Time F

1979
An analysis of the reduction by creatinol O-phosphate of the myocardial lesions evoked by isoprenaline in the rat.
    Arzneimittel-Forschung, 1979, Volume: 29, Issue:9a

    Topics: Animals; Cardiomyopathies; Coronary Circulation; Creatine; Isoproterenol; Male; Microcirculation; My

1979
[Accumulation of tetracycline, Sn-tetracycline, and 99mTc-Sn-tetracykline in isoprenaline-damaged rat myocardium (author's transl)].
    Casopis lekaru ceskych, 1978, May-05, Volume: 117, Issue:18

    Topics: Animals; Cardiomyopathies; Disease Models, Animal; Isoproterenol; Myocardium; Rats; Technetium; Tetr

1978
A temporal profile of changes in myocardial copper after isoproterenol induced cardiac necrosis.
    Japanese circulation journal, 1978, Volume: 42, Issue:6

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cardiomyopathies; Copper; Electrocardiog

1978
Catecholamine stimulation of myocardial oxygen consumption in porcine malignant hyperthermia.
    Anesthesiology, 1978, Volume: 49, Issue:5

    Topics: Animals; Cardiomyopathies; Catecholamines; Fever; Halothane; Isoproterenol; Oxygen Consumption; Prop

1978
Impairment of autonomically mediated heart rate control in patients with cardiac dysfunction.
    Circulation research, 1975, Volume: 36, Issue:5

    Topics: Adolescent; Adult; Atropine; Autonomic Nervous System; Cardiomyopathies; Exercise Test; Female; Hear

1975
[Quantitative evaluation of histochemical examinations of the protective effect of KMg-aspartate upon necroses of the myocardium experimentally induced by isoproterenol (author's transl)].
    Bratislavske lekarske listy, 1976, Volume: 65, Issue:3

    Topics: Animals; Aspartic Acid; Cardiomyopathies; Disease Models, Animal; Dogs; Isoproterenol; Magnesium; Ne

1976
[Modification of the isoprenaline-induced myocardial necrosis using trapidil].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1976, Sep-15, Volume: 31, Issue:18

    Topics: Animals; Cardiomyopathies; Disease Models, Animal; Isoproterenol; Male; Myocardial Infarction; Necro

1976
Maximal rate of fall of left ventricular pressure in cardiomyopathy and constrictive pericarditis.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1975, Jul-26, Volume: 49, Issue:32

    Topics: Adolescent; Adult; Aged; Calcium; Cardiac Output; Cardiomyopathies; Female; Heart; Heart Ventricles;

1975
Restriction of isoproterenol-induced myocardial Ca uptake and necrotization in rats by a new Ca-antagonistic compound (ethyl-4-(3,4,5-trimethoxycinnamoyl) piperazinyl acetate (Vascordil)).
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 6

    Topics: Animals; Biological Transport; Calcium; Cardiomyopathies; Cinnamates; Dose-Response Relationship, Dr

1975
Transmural metabolic gradients of the canine left ventricle in coronary constriction, systemic hypoxia, hemorrhagic shock, and isoproterenol infusion.
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 6

    Topics: Adenine Nucleotides; Animals; Cardiomyopathies; Coronary Disease; Dogs; Hypoxia; Isoproterenol; Lact

1975
Myocardial metabolism at different environmental temperatures in experimental myocardial necrosis.
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 6

    Topics: Adrenal Glands; Alanine Transaminase; Animals; Ascorbic Acid; Aspartate Aminotransferases; Cardiomyo

1975
Membrane phospholipid metabolism in the isoproterenol-induced cardiomyopathy of the rat.
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 6

    Topics: Animals; Cardiolipins; Cardiomyopathies; Cell Membrane; Cytidine Monophosphate; Isoproterenol; Liver

1975
Changes in fatty acid composition of cardiac lipids accompanying myocardial necrosis.
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 6

    Topics: Animals; Cardiomyopathies; Cod Liver Oil; Fatty Acids; Fatty Acids, Unsaturated; Isoproterenol; Lipi

1975
Disturbed myocardial calcium metabolism: a possible pathogenetic factor in the hereditary cardiomyopathy of the Syrian hamster.
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 6

    Topics: Age Factors; Animals; Calcium; Cardiomyopathies; Cricetinae; Female; Heart; Isoproterenol; Male; Ver

1975
Key role of Ca in the production of noncoronarogenic myocardial necroses.
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 6

    Topics: Adenosine Triphosphate; Animals; Calcium; Cardiomyopathies; Heart; Humans; Isoproterenol; Muscles; N

1975
Morphological changes after combined administration of isoproterenol and K+,Mg2+-aspartate as a physiological Ca2+ antagonist.
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 6

    Topics: Animals; Aspartic Acid; Calcium; Cardiomyopathies; Dogs; Glycogen; Isoproterenol; Magnesium; Male; M

1975
[Myocardial DNA and cell count following isoproterenol-induced myocardial necrosis in the rat].
    Verhandlungen der Deutschen Gesellschaft fur Pathologie, 1975, Volume: 59

    Topics: Animals; Cardiomyopathies; Cell Count; DNA; Female; Heart; Isoproterenol; Myocardium; Necrosis; Rats

1975
[Isoproterenol-induced changes of autoradiographic 45 Ca-distribution in the myocardium. Inhibition by Ca-antagonists].
    Verhandlungen der Anatomischen Gesellschaft, 1975, Volume: 69

    Topics: Animals; Autoradiography; Calcium; Calcium Radioisotopes; Cardiomyopathies; Heart; Isoproterenol; My

1975
Alterations in Ca(2+)-channels during the development of diabetic cardiomyopathy.
    Molecular and cellular biochemistry, 1992, Feb-12, Volume: 109, Issue:2

    Topics: Animals; Blood Glucose; Brain; Calcium; Calcium Channels; Calcium-Transporting ATPases; Cardiomyopat

1992
Phosphodiesterase inhibition by enoximone in preparations from nonfailing and failing human hearts.
    Arzneimittel-Forschung, 1992, Volume: 42, Issue:4

    Topics: Adult; Cardiomyopathies; Chromatography, DEAE-Cellulose; Enoximone; Female; Heart; Humans; Imidazole

1992
Profound, reversible, myocardial depression in acute asthma treated with high-dose catecholamines.
    Critical care medicine, 1992, Volume: 20, Issue:5

    Topics: Administration, Inhalation; Adult; Albuterol; Aminophylline; Asthma; Barotrauma; Cardiomyopathies; C

1992
Autonomic mechanisms in heart rate variability after isoproterenol-induced myocardial damage in rats.
    Journal of the autonomic nervous system, 1992, Volume: 38, Issue:1

    Topics: Animals; Autonomic Nervous System; Cardiomyopathies; Electrocardiography; Fourier Analysis; Heart Ra

1992
Reversal of changes of myocardial lipids by chronic administration of aspirin in isoproterenol-induced myocardial damage in rats.
    Indian journal of physiology and pharmacology, 1992, Volume: 36, Issue:1

    Topics: Animals; Aspirin; Cardiomyopathies; Cholesterol; Cholesterol, LDL; Fatty Acids, Nonesterified; Heart

1992
Inefficient muscarinic transduction in cardiomyopathic Syrian hamsters.
    Journal of molecular and cellular cardiology, 1991, Volume: 23, Issue:11

    Topics: Adenylyl Cyclases; Animals; Carbachol; Cardiomyopathies; Colforsin; Cricetinae; Cyclic AMP; GTP-Bind

1991
Effectiveness of cardiac glycosides in human myocardium with and without "downregulated" beta-adrenoceptors.
    Journal of cardiovascular pharmacology, 1990, Volume: 15, Issue:5

    Topics: Adult; Cardiac Glycosides; Cardiomyopathies; Down-Regulation; Female; Heart; Heart Failure; Humans;

1990
Comparative effects of arotinolol, labetalol and propranolol on regional myocardial dysfunction induced by flow-limiting coronary stenosis in anesthetized dogs.
    Japanese journal of pharmacology, 1990, Volume: 53, Issue:3

    Topics: Adrenergic beta-Antagonists; Anesthesia; Animals; Blood Pressure; Cardiomyopathies; Coronary Vessels

1990
Dynamics of lipid peroxidation in isoprenaline-induced myocardiopathy.
    Cor et vasa, 1991, Volume: 33, Issue:4

    Topics: Animals; Brain; Cardiomyopathies; Isoproterenol; Lipid Peroxidation; Liver; Luminescent Measurements

1991
Contractile responses of myocytes isolated from patients with cardiomyopathy.
    European heart journal, 1991, Volume: 12 Suppl D

    Topics: Action Potentials; Calcium; Cardiomyopathies; Electric Stimulation; Heart Defects, Congenital; Human

1991
[Functional activity of polymorphonuclear leukocytes in isoprenaline-induced cardiomyopathy in rats].
    Biulleten' eksperimental'noi biologii i meditsiny, 1990, Volume: 110, Issue:12

    Topics: Animals; Cardiomyopathies; Isoproterenol; Lipid Peroxidation; Liver; Luminescent Measurements; Lymph

1990
Kinetic properties of mitochondrial ATPase during isoproterenol-induced cardiomyopathy.
    The International journal of biochemistry, 1990, Volume: 22, Issue:6

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Cardiomyopathies; Detergents; Hydrogen-I

1990
Adriamycin cardiomyopathy in the rabbit: alterations in contractile proteins and myocyte function.
    Cardiovascular research, 1990, Volume: 24, Issue:10

    Topics: Animals; Calcium-Transporting ATPases; Cardiomyopathies; Collagen; Creatine Kinase; Doxorubicin; Ele

1990
Isoenzyme profiles of creatine kinase, lactate dehydrogenase, and aspartate aminotransferase in the diabetic heart: comparison with hereditary and catecholamine cardiomyopathies.
    Cardiovascular research, 1990, Volume: 24, Issue:7

    Topics: Animals; Aspartate Aminotransferases; Cardiomyopathies; Catecholamines; Creatine Kinase; Cricetinae;

1990
Influence of phenytoin on isoproterenol-induced myocardial fibrosis in rats.
    American journal of veterinary research, 1990, Volume: 51, Issue:1

    Topics: Animals; Cardiomyopathies; Female; Fibrosis; Isoproterenol; Myocardium; Phenytoin; Rats; Rats, Inbre

1990
Raised vascular calcium in an animal model: effects on aortic function.
    Cardiovascular research, 1990, Volume: 24, Issue:1

    Topics: Animals; Aorta; Calcinosis; Calcium; Cardiomyopathies; Disease Models, Animal; Ergocalciferols; Fema

1990
Decreased bioactivity of the guanine nucleotide-binding protein that stimulates adenylate cyclase in hearts from cardiomyopathic Syrian hamsters.
    The Journal of clinical investigation, 1989, Volume: 84, Issue:1

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Autoradiography; Blotting, Northern; Cardiomyop

1989
Influence of positive inotropic agents on intracellular calcium transients. Part II. Cardiomyopathic hamster hearts.
    American heart journal, 1989, Volume: 118, Issue:6

    Topics: Animals; Biomechanical Phenomena; Calcium; Cardiac Output, Low; Cardiomyopathies; Cardiotonic Agents

1989
Enhanced formation of lipid peroxides might contribute to the high sensitivity of spontaneously hypertensive rats towards isoproterenol-induced myocardial damage.
    Biomedica biochimica acta, 1989, Volume: 48, Issue:9

    Topics: Animals; Aspartate Aminotransferases; Body Weight; Cardiomyopathies; Coronary Disease; Creatine Kina

1989
[The effect of vitaton on a model of isoprenaline myocardiopathy in rats].
    Eksperimentalna meditsina i morfologiia, 1989, Volume: 28, Issue:4

    Topics: Animals; Cardiomyopathies; Electrocardiography; Heart; Isoproterenol; Male; Rats; Rats, Inbred Strai

1989
[Effect of estrogens and thyroid hormones on the development of isoprenaline-induced myocardiodystrophy].
    Kardiologiia, 1988, Volume: 28, Issue:8

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiomyopathies; Cyclic AMP; Estradiol; Estrogens; Fe

1988
Increased responsiveness to stimulation of alpha- but not beta-adrenoceptors in the hereditary cardiomyopathy of the Syrian hamster. Intact adenosine- and cholinoceptor-mediated isoprenaline antagonistic effect.
    European journal of pharmacology, 1986, Sep-09, Volume: 128, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Body Weight; Carbachol; Cardiomyopathi

1986
Perturbation of the sarcolemmal membrane in isoproterenol-induced myocardial injury of the rat. Permeability and freeze-fracture studies in vivo and in vitro.
    The American journal of pathology, 1989, Volume: 134, Issue:1

    Topics: Animals; Cardiomyopathies; Freeze Fracturing; Horseradish Peroxidase; In Vitro Techniques; Isoproter

1989
Quantification of myocardial necrosis and cardiac hypertrophy in isoproterenol-treated rats.
    Research communications in chemical pathology and pharmacology, 1987, Volume: 57, Issue:1

    Topics: Animals; Aspartate Aminotransferases; Cardiomegaly; Cardiomyopathies; Creatine Kinase; DNA; Isoprote

1987
Influence of the diabetic state on isoproterenol-induced cardiac necrosis.
    Journal of molecular and cellular cardiology, 1985, Volume: 17, Issue:4

    Topics: Animals; Cardiomyopathies; Cyclic AMP; Diabetes Mellitus, Experimental; Heart; Insulin; Isoprotereno

1985
Sarcolemmal Na+-Ca2+ exchange during the development of genetically determined cardiomyopathy.
    Biochemical and biophysical research communications, 1985, Dec-17, Volume: 133, Issue:2

    Topics: Aging; Animals; Biological Transport; Calcium; Cardiomyopathies; Cricetinae; Isoproterenol; Mesocric

1985
The effect of oxidized isoprenaline on the chick embryonic heart.
    Canadian journal of physiology and pharmacology, 1986, Volume: 64, Issue:7

    Topics: Adrenochrome; Animals; Body Weight; Cardiomyopathies; Chick Embryo; Cyclic AMP; Isoproterenol; Myoca

1986
Effect of Salmonella typhimurium porins on the cardiovascular and renal apparatus.
    Journal of medicine, 1986, Volume: 17, Issue:5-6

    Topics: Animals; Bacterial Outer Membrane Proteins; Barium; Barium Compounds; Blood Pressure; Cardiomyopathi

1986
Protective effect of the new calcium antagonist anipamil against isoprenaline-induced cardionecrosis in rats.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:2

    Topics: Acid Phosphatase; Animals; Calcium Channel Blockers; Cardiomyopathies; Glucosephosphate Dehydrogenas

1988
Acute insulin treatment normalizes the resistance to the cardiotoxic effect of isoproterenol in streptozotocin diabetic rats. A morphometric study of isoproterenol induced myocardial fibrosis.
    Virchows Archiv. A, Pathological anatomy and histopathology, 1985, Volume: 405, Issue:2

    Topics: Animals; Blood Glucose; Cardiomyopathies; Diabetes Mellitus, Experimental; Drug Resistance; Female;

1985
Inhibition of the effects of adenosine on force of contraction and the slow calcium inward current by pertussis toxin is associated with myocardial lesions.
    Cardiovascular research, 1988, Volume: 22, Issue:2

    Topics: Action Potentials; Adenosine; Animals; Calcium; Cardiomyopathies; Guinea Pigs; Isoproterenol; Myocar

1988
Carbon monoxide poisoning at a lowered myocardial adaptation capacity: animal ECG models.
    Activitas nervosa superior, 1988, Volume: 30, Issue:4

    Topics: Adaptation, Physiological; Animals; Carbon Monoxide Poisoning; Cardiomyopathies; Cholesterol; Electr

1988
Ability of the electrocardiogram to detect myocardial lesions in isoproterenol induced rat cardiomyopathy.
    Cardiovascular research, 1987, Volume: 21, Issue:12

    Topics: Ajmaline; Animals; Cardiomyopathies; Electrocardiography; Heart; Isoproterenol; Male; Myocardium; Ra

1987
Effect of isoprenaline on tissue elastin content and serum elastolytic activity in normal and hydrazinophthalazine-treated rats.
    Biomedica biochimica acta, 1987, Volume: 46, Issue:10

    Topics: Animals; Cardiomyopathies; Collagen Diseases; Elastin; Hydralazine; Isoproterenol; Male; Pancreatic

1987
Relation between graded, subcritical impairments of coronary flow reserve and regional myocardial dysfunction induced by isoproterenol infusion in dogs.
    American heart journal, 1987, Volume: 113, Issue:4

    Topics: Animals; Cardiomyopathies; Coronary Circulation; Coronary Disease; Dogs; Female; Hemodynamics; Isopr

1987
Biphasic changes in the sarcolemmal phosphatidylethanolamine N-methylation activity in catecholamine-induced cardiomyopathy.
    Journal of molecular and cellular cardiology, 1987, Volume: 19, Issue:4

    Topics: Animals; Cardiomyopathies; Isoproterenol; Male; Methylation; Methyltransferases; Phosphatidylethanol

1987
The effect of ouabain on hearts of cardiomyopathic hamsters: potentiation by isoproterenol.
    Journal of molecular and cellular cardiology, 1987, Volume: 19, Issue:6

    Topics: Animals; Cardiomyopathies; Cricetinae; Drug Synergism; Heart; Isoproterenol; Male; Myocardial Contra

1987
The effect of cordarone on isoproterenol-induced damage to the myocardium in rats.
    Experimental pathology, 1986, Volume: 29, Issue:4

    Topics: Amiodarone; Animals; Benzofurans; Cardiomyopathies; Isoproterenol; Male; Necrosis; Rats; Rats, Inbre

1986
Does an impaired adenosine mediated feedback control play a role in the development of hereditary dystrophic cardiomyopathy?
    Cardiovascular research, 1986, Volume: 20, Issue:8

    Topics: Adenosine; Animals; Cardiomyopathies; Cricetinae; Depression, Chemical; Feedback; Female; In Vitro T

1986
Contractile properties of papillary muscle from young cardiomyopathic hamsters: effects of isoprenaline.
    Cardiovascular research, 1986, Volume: 20, Issue:8

    Topics: Animals; Cardiomyopathies; Cricetinae; Female; Isoproterenol; Male; Mesocricetus; Myocardial Contrac

1986
[Effect of enkephalins on the course of experimental izadrin-induced myocardial necrosis in the rabbit].
    Kardiologiia, 1985, Volume: 25, Issue:12

    Topics: Animals; Cardiomyopathies; Creatine Kinase; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Isoe

1985
Myocardial ultrastructural alterations in ducklings with isoproterenol-induced cardiotoxicosis.
    American journal of veterinary research, 1986, Volume: 47, Issue:2

    Topics: Animals; Cardiomyopathies; Ducks; Isoproterenol; Male; Microscopy, Electron; Myocardium; Necrosis

1986
[Prophylactic effect of coenzyme Q10 on isoproterenol-induced myocardial necrosis in rats].
    Zhonghua xin xue guan bing za zhi, 1985, Volume: 13, Issue:1

    Topics: Animals; Cardiomyopathies; Coenzymes; Female; Isoproterenol; Male; Mitochondria, Heart; Myocardium;

1985
Alterations in isoproterenol-induced cardiac metabolic changes by perhexiline.
    The Indian journal of medical research, 1985, Volume: 81

    Topics: Adenosine Triphosphate; Animals; Cardiomyopathies; Female; Glycogen; Isoproterenol; L-Lactate Dehydr

1985
Essential contribution of thrombocytes to the occurrence of catecholamine-induced cardiac necroses.
    Journal of molecular and cellular cardiology, 1985, Volume: 17, Issue:4

    Topics: Animals; Blood Platelets; Cardiomyopathies; Catecholamines; Female; Isoproterenol; Microcirculation;

1985
Adaptive changes in subcellular calcium transport during catecholamine-induced cardiomyopathy.
    Journal of molecular and cellular cardiology, 1985, Volume: 17, Issue:4

    Topics: Animals; Biological Transport, Active; Calcium; Cardiomyopathies; Catecholamines; Isoproterenol; Kin

1985
Experimental catecholamine-induced myocardial necrosis. II. Temporal development of isoproterenol-induced contraction band lesions correlated with ECG, hemodynamic and biochemical changes.
    Journal of molecular and cellular cardiology, 1985, Volume: 17, Issue:7

    Topics: Adenosine Triphosphate; Animals; Cardiomyopathies; Dogs; Electrocardiography; Female; Glycogen; Hemo

1985
Isoprenaline-evinced disturbances in action potentials from hearts of young cardiomyopathic hamsters.
    Cardiovascular research, 1985, Volume: 19, Issue:9

    Topics: Action Potentials; Animals; Cardiomyopathies; Cricetinae; Dose-Response Relationship, Drug; Female;

1985
Diet and cardiac arrhythmia: effects of lipids on age-related changes in myocardial function in the rat.
    Annals of nutrition & metabolism, 1985, Volume: 29, Issue:5

    Topics: Age Factors; Animals; Arrhythmias, Cardiac; Blood Pressure; Calcium; Cardiomyopathies; Dietary Fats;

1985
Panel discussion: the treatment of hypertrophic cardiomyopathy with beta-adrenergic blockade.
    Postgraduate medical journal, 1972, Volume: 48, Issue:566

    Topics: Acetanilides; Adrenergic beta-Antagonists; Amino Alcohols; Cardiomyopathies; Cardiomyopathy, Hypertr

1972
Cardioselective beta blockade in hypertrophic cardiomyopathy.
    Acta cardiologica, 1972

    Topics: Adolescent; Adrenergic beta-Antagonists; Blood Pressure; Cardiac Catheterization; Cardiac Output; Ca

1972
Ventricular extrasystoles induced by epinephrine, nicotine, ethanol, and vasopressin in dogs with myocardial lesions.
    Toxicology and applied pharmacology, 1969, Volume: 15, Issue:1

    Topics: Animals; Aspartate Aminotransferases; Cardiac Complexes, Premature; Cardiomyopathies; Creatine Kinas

1969
Experimental cardiomyopathies in poikilotherms.
    Recent advances in studies on cardiac structure and metabolism, 1973, Volume: 2

    Topics: Alligators and Crocodiles; Amphibians; Animals; Anura; Arteries; Bufo bufo; Cardiomyopathies; Corona

1973
Estimation of grossly detectable isoproterenol-induced myocardiopathies in rats using the ridit transformation.
    Toxicology and applied pharmacology, 1966, Volume: 9, Issue:2

    Topics: Animals; Cardiomegaly; Cardiomyopathies; Female; Isoproterenol; Necrosis; Organ Size; Rats; Statisti

1966
[Idiopathic myocardiopathy without obstructive or constrictive complications, well tolerated for 24 years].
    Archives des maladies du coeur et des vaisseaux, 1967, Volume: 60, Issue:11

    Topics: Adult; Bundle-Branch Block; Cardiac Catheterization; Cardiomegaly; Cardiomyopathies; Electrocardiogr

1967
Development of modern components of the mechanism of cardiac hypertrophy.
    Circulation research, 1974, Volume: 35, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cardiomegaly; Cardiomyopathies; Cold Tempera

1974
Cardiac catecholamine synthesis, turnover, and metabolism with isoproterenol-induced myocytolysis.
    Cardiovascular research, 1971, Volume: 5, Issue:3

    Topics: Adrenal Glands; Animals; Brain; Cardiac Output; Cardiomyopathies; Catechols; Dogs; In Vitro Techniqu

1971
[3d heart sound].
    Japanese circulation journal, 1971, Volume: 35, Issue:10

    Topics: Adult; Animals; Arrhythmias, Cardiac; Cardiac Catheterization; Cardiomyopathies; Dogs; Ductus Arteri

1971
[Effect of Cardilan Spofa (K and Mg asparaginate) on the acid-base equilibrium during experimental isoprenaline lesions of the myocardium].
    Ceskoslovenska farmacie, 1974, Volume: 23, Issue:7

    Topics: Acid-Base Equilibrium; Acidosis; Animals; Aspartic Acid; Cardiomyopathies; Heart; Isoproterenol; Mag

1974
[Dynamic follow-up study of the influence of K and Mg asparaginate (Cardilan Spofa) on the development of isoprenaline-induced myocardial necroses in the electron microscopy picture].
    Ceskoslovenska patologie, 1974, Volume: 10, Issue:4

    Topics: Animals; Asparagine; Cardiomyopathies; Disease Models, Animal; Heart; Isoproterenol; Magnesium; Micr

1974
[A new method of evaluation of ventricular contractility].
    Bollettino della Societa italiana di cardiologia, 1974, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Cardiomyopathies; Child; Female; Heart Function Tests; Heart Valve Diseases; Hear

1974
Myocardial fiber necrosis due to intracellular Ca overload-a new principle in cardiac pathophysiology.
    Recent advances in studies on cardiac structure and metabolism, 1974, Volume: 4

    Topics: Ammonium Chloride; Animals; Biological Transport; Calcitonin; Calcium; Cardiomyopathies; Dihydrotach

1974
Isoproterenol myocytolysis and myocardial calcium.
    Recent advances in studies on cardiac structure and metabolism, 1974, Volume: 4

    Topics: Animals; Biological Transport; Calcium; Cardiomyopathies; Dose-Response Relationship, Drug; Isoprote

1974
Effect of isoproterenol on coronary blood flow in primary myocardial disease.
    Circulation, 1974, Volume: 50, Issue:3

    Topics: Blood Pressure; Cardiac Catheterization; Cardiac Output; Cardiomyopathies; Coronary Circulation; Hea

1974
[Mechanical properties of the heart in apparently primary non-obstructive myocardiopathies].
    Archives des maladies du coeur et des vaisseaux, 1972, Volume: 65, Issue:1

    Topics: Angiocardiography; Cardiac Volume; Cardiomyopathies; Heart; Heart Failure; Heart Function Tests; Hea

1972
[Myocardial lesions induced by isoproterenol with the aid of diffusion tracers].
    La Vie medicale au Canada francais, 1972, Volume: 1, Issue:6

    Topics: Animals; Cardiomyopathies; Isoproterenol; Methods; Rats

1972
Concerning the problem of granular disintegration in experimental cardiomyopathies.
    Canadian journal of physiology and pharmacology, 1972, Volume: 50, Issue:11

    Topics: Animals; Birefringence; Cardiomyopathies; Coronary Vessels; Heart; Isoproterenol; Ligation; Male; My

1972
[Pressure and contractility of the left ventricle under various conditions in the Syrian golden hamster with hereditary cardiomyopathy].
    Verhandlungen der Deutschen Gesellschaft fur Kreislaufforschung, 1972, Volume: 38

    Topics: Animals; Blood Pressure; Cardiomyopathies; Cricetinae; Dextrans; Disease Models, Animal; Heart Ventr

1972
Recent advances in therapy for refractory congestive heart failure.
    Geriatrics, 1973, Volume: 28, Issue:3

    Topics: Adrenal Cortex Hormones; Aminophylline; Cardiac Catheterization; Cardiomyopathies; Dextrothyroxine;

1973
[Various factors influencing the development of experimental myocardial necrosis].
    Ceskoslovenska fysiologie, 1973, Volume: 22, Issue:1

    Topics: Animals; Cardiomyopathies; Disease Models, Animal; Isoproterenol; Lipid Metabolism; Necrosis; Rats

1973
Myocardial necrosis in the rat: a comparison between isoprenaline, orciprenaline, salbutamol and terbutaline.
    Cardiology, 1973, Volume: 58, Issue:3

    Topics: Albuterol; Animals; Cardiomyopathies; Female; Heart; Isoproterenol; Male; Metaproterenol; Myocardium

1973
Pathogenesis of isoproterenol-induced myocardial alterations: functional and morphological correlates.
    Recent advances in studies on cardiac structure and metabolism, 1973, Volume: 3

    Topics: Animals; Blood Pressure; Cardiomyopathies; Coronary Circulation; Isoproterenol; Male; Myocardium; Ra

1973
Ultrastructural changes in isoproterenol-induced atrial necrosis.
    Recent advances in studies on cardiac structure and metabolism, 1973, Volume: 2

    Topics: Animals; Cardiomyopathies; Desoxycorticosterone; Disease Models, Animal; Isoproterenol; Male; Micros

1973
Ca overload as the determinant factor in the production of catecholamine-induced myocardial lesions.
    Recent advances in studies on cardiac structure and metabolism, 1973, Volume: 2

    Topics: Adenosine Triphosphate; Animals; Calcium; Cardiomyopathies; Dihydrotachysterol; Heart; Hydrocortison

1973
[Value of the carotidogram in idiopathic muscular stenosis of the left ventricle. Study of 50 cases of 1,668 diverse cardiopathies].
    Archives des maladies du coeur et des vaisseaux, 1969, Volume: 62, Issue:2

    Topics: Adolescent; Adult; Aged; Cardiomyopathies; Cardiomyopathy, Hypertrophic; Carotid Arteries; Child; El

1969
[Mechanical and contractile properties of human myocardium. 3. Application of the automatic analysis system of contraction to the study of nonobstructive myocardiopathies].
    Archives des maladies du coeur et des vaisseaux, 1971, Volume: 64, Issue:4

    Topics: Cardiac Catheterization; Cardiac Output; Cardiac Volume; Cardiomyopathies; Computers; Heart Ventricl

1971
Echocardiographic diagnosis of idiopathic hypertrophic cardiomyopathy without outflow obstruction.
    Circulation, 1972, Volume: 46, Issue:5

    Topics: Adult; Amyl Nitrite; Angiocardiography; Cardiac Catheterization; Cardiomyopathies; Coronary Angiogra

1972
[Various principles in the determination of cytoplasm birefringence in cardiomyopathies].
    Microscopica acta, 1971, Volume: 71, Issue:2

    Topics: Animals; Birefringence; Cardiomyopathies; Cytoplasm; Isoproterenol; Light; Methods; Microscopy, Pola

1971
Study on the idiopathic cardiomyopathy. Diagnostic value of the apexcardiogram, 131 Cs scintiscanning of the heart and plasma hydroxyproline.
    Japanese circulation journal, 1971, Volume: 35, Issue:7

    Topics: Adult; Amyl Nitrite; Autopsy; Cardiomyopathies; Cesium Isotopes; Child; Collagen; Collagen Diseases;

1971
Clinical features of idiopathic hypertrophic cardiomyopathy.
    Japanese circulation journal, 1971, Volume: 35, Issue:7

    Topics: Adolescent; Adult; Amyl Nitrite; Angiocardiography; Blood Pressure; Cardiac Catheterization; Cardiom

1971
[Carotid pulse curve in obstructive cardiomyopathy during treatment with isoproterenol and propranolol].
    Helvetica medica acta. Supplementum, 1970

    Topics: Angiocardiography; Cardiac Catheterization; Cardiomyopathies; Carotid Arteries; Humans; Isoprotereno

1970
Experimental "metabolic" cardiopathies and their relationship to human heart diseases. Concluding remarks.
    Annals of the New York Academy of Sciences, 1969, Jan-31, Volume: 156, Issue:1

    Topics: Animals; Cardiomyopathies; Heart Diseases; Heart Failure; Humans; Ischemia; Isoproterenol; Myocardia

1969
[Hemodynamic study of non obstructive myocardiopathies of undetermined origin].
    Acta cardiologica, 1966, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Cardiomyopathies; Female; Humans; Isoproterenol; Male; Middle Aged

1966
Effect of isoprenaline on experimentally produced immunologic cardiac lesions.
    Indian journal of medical sciences, 1969, Volume: 23, Issue:2

    Topics: Animals; Antibodies, Anti-Idiotypic; Cardiomyopathies; Female; Heart; Isoproterenol; Male; Myocardiu

1969
Morphological changes in the myocardium in experimental cardiomyofibrosis.
    Cor et vasa, 1969, Volume: 11, Issue:3

    Topics: Animals; Cardiomyopathies; Diet; Isoproterenol; Myocardium; Rats

1969
[Clinical findings in idiopathic myocardial diseases].
    Naika. Internal medicine, 1971, Volume: 28, Issue:2

    Topics: Adolescent; Adult; Biopsy; Cardiomyopathies; Catheterization; Electrocardiography; Female; Humans; I

1971
Effects of isoproterenol on the pulmonary blood volume in patients with valvular heart disease and primary myocardial disease.
    Circulation, 1968, Volume: 37, Issue:2

    Topics: Adult; Blood Flow Velocity; Blood Pressure; Blood Volume; Cardiac Catheterization; Cardiomyopathies;

1968
Nonobstructive primary myocardial disease. Hemodynamic studies in fourteen cases.
    The American journal of cardiology, 1968, Volume: 22, Issue:4

    Topics: Blood Pressure; Brachial Artery; Cardiac Catheterization; Cardiac Output; Cardiomyopathies; Cineangi

1968
[Isoproterenol in the hemodynamic study of obstructive heart disease].
    Revista medica de Chile, 1968, Volume: 96, Issue:10

    Topics: Blood Pressure; Cardiomyopathies; Heart Rate; Humans; Isoproterenol; Thrombosis

1968
[On the continuous treatment of Adams-Stokes paroxysms and conduction disorders of the heart with a long-acting isoprenaline preparation].
    Praxis, 1968, Jul-30, Volume: 57, Issue:30

    Topics: Adams-Stokes Syndrome; Adult; Aged; Arrhythmias, Cardiac; Cardiomyopathies; Delayed-Action Preparati

1968
Temperature and experimental acute cardiac necrosis.
    Canadian journal of physiology and pharmacology, 1969, Volume: 47, Issue:3

    Topics: Animals; Body Temperature Regulation; Cardiomyopathies; Crowding; Environment; Isoproterenol; Male;

1969
Hemodynamic effects of glucagon in patients with heart disease.
    Circulation, 1969, Volume: 39, Issue:1

    Topics: Blood Glucose; Blood Pressure; Cardiac Catheterization; Cardiac Output; Cardiomyopathies; Glucagon;

1969
Possible protective action of antialdosterone compounds in myocardial necrosis in rats.
    British journal of pharmacology, 1969, Volume: 35, Issue:3

    Topics: Animals; Cardiomyopathies; Isoproterenol; Mineralocorticoid Receptor Antagonists; Necrosis; Rats; Sp

1969
[Effect of isoproterenol on the hemodyanmics of obstructive myocardiopathies].
    Revue francaise d'etudes cliniques et biologiques, 1965, Volume: 10, Issue:10

    Topics: Cardiomyopathies; Hemodynamics; Humans; Isoproterenol

1965
Electron microscopic observations on lysosomes and related cytoplasmic components of normal and pathological cardiac muscle.
    The Anatomical record, 1965, Volume: 153, Issue:2

    Topics: Animals; Cardiomyopathies; Cytoplasmic Granules; Epinephrine; Humans; Isoproterenol; Lysosomes; Micr

1965
Right ventricular involvement in obstructive cardiomyopathies: haemodynamic studies in 13 cases.
    British heart journal, 1966, Volume: 28, Issue:1

    Topics: Adolescent; Adult; Aged; Cardiac Catheterization; Cardiomyopathies; Cineangiography; Female; Heart A

1966
Protection of rats from isoproterenol induced myocardial necrosis by trolnitrate phosphate (Metamine).
    Experientia, 1966, Feb-15, Volume: 22, Issue:2

    Topics: Animals; Cardiomyopathies; Drug Antagonism; Isoproterenol; Necrosis; Nitrates; Rats; Vasodilator Age

1966
Dose-time effect of isoproterenol on aspartate amino-transferase and necrosis of the rat heart.
    Toxicology and applied pharmacology, 1966, Volume: 8, Issue:3

    Topics: Animals; Aspartate Aminotransferases; Cardiomyopathies; Isoproterenol; Male; Myocardium; Necrosis; R

1966