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isoproterenol and Cancer of Pancreas

isoproterenol has been researched along with Cancer of Pancreas in 9 studies

Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.

Research Excerpts

ExcerptRelevanceReference
"Neuropeptide Y (NPY) has been shown to inhibit insulin secretion from the islets of Langerhans."5.30Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells. ( Bloom, SR; Ghatei, MA; Hurley, JD; Karlsen, AE; Kulkarni, RN; Morgan, DG; Smith, DM; Wang, RM; Wang, ZL, 1998)
" Amylin significantly reduced insulin secretion in rat insulinoma cell lines (Rin m5F cells) that were stimulated by either isoproterenol and forskolin, but it did not affect insulin secretion stimulated by isobutyl-methylxanthine (IBMX) or dibutyryl cyclic-adenosine monophosphate (db-cAMP)."3.68The effects of amylin on insulin secretion from Rin m5F cells and glycogen synthesis and lipogenesis in rat primary cultured hepatocytes. ( Abe, S; Ishizuka, J; Murakami, M; Satoh, Y; Shintani, S; Suzuki, K; Suzuki, S; Thompson, JC; Toyota, T, 1992)
"The response of insulinoma tissue to glucose, alpha-ketoisocaproate, and the modifiers of insulin release, tolbutamide, isoproterenol, and acetylcholine, was studied."3.67Pharmacological modifications of insulin release in vitro from fuel-responsive transplantable insulinomas. ( Ferguson, DC; Hoenig, M; Matschinsky, FM, 1984)
"Neuropeptide Y (NPY) has been shown to inhibit insulin secretion from the islets of Langerhans."1.30Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells. ( Bloom, SR; Ghatei, MA; Hurley, JD; Karlsen, AE; Kulkarni, RN; Morgan, DG; Smith, DM; Wang, RM; Wang, ZL, 1998)
"One of the major manifestations of the carcinoid syndrome is secretory diarrhea thought to be due to overproduction of 5-hydroxytryptamine (5-HT)."1.28The effect of somatostatin on 5-hydroxytryptamine release from a carcinoid tumor. ( Haber, B; Ishizuka, J; Lawrence, JP; Thompson, JC; Townsend, CM, 1990)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19902 (22.22)18.7374
1990's4 (44.44)18.2507
2000's2 (22.22)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Eng, JW1
Reed, CB1
Kokolus, KM1
Pitoniak, R1
Utley, A1
Bucsek, MJ1
Ma, WW1
Repasky, EA1
Hylander, BL1
Askari, MD1
Tsao, MS1
Schuller, HM2
Al-Wadei, HA1
Majidi, M1
Hoenig, M1
Ferguson, DC1
Matschinsky, FM1
Vea, H1
Trovik, TS1
Sager, G1
Birkeland, K1
Revhaug, A1
Sundsfjord, J1
Jorde, R1
Morgan, DG1
Kulkarni, RN1
Hurley, JD1
Wang, ZL1
Wang, RM1
Ghatei, MA1
Karlsen, AE1
Bloom, SR1
Smith, DM1
Suzuki, S1
Murakami, M1
Abe, S1
Satoh, Y1
Shintani, S1
Ishizuka, J2
Suzuki, K1
Thompson, JC2
Toyota, T1
Lawrence, JP1
Haber, B1
Townsend, CM1
Pasmantier, R1
Danoff, A1
Fleischer, N1
Schubart, UK1

Other Studies

9 other studies available for isoproterenol and Cancer of Pancreas

ArticleYear
Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β2-adrenergic receptor activation.
    Nature communications, 2015, Mar-10, Volume: 6

    Topics: Adrenergic beta-Agonists; Albumins; Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Cell L

2015
The tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone stimulates proliferation of immortalized human pancreatic duct epithelia through beta-adrenergic transactivation of EGF receptors.
    Journal of cancer research and clinical oncology, 2005, Volume: 131, Issue:10

    Topics: Adrenergic beta-Agonists; Blotting, Western; Carcinogens; Carcinoma, Pancreatic Ductal; Cell Line, T

2005
GABA B receptor is a novel drug target for pancreatic cancer.
    Cancer, 2008, Feb-15, Volume: 112, Issue:4

    Topics: Adrenergic beta-Agonists; Baclofen; Blotting, Western; Bromodeoxyuridine; Cell Line; Cell Line, Tumo

2008
Pharmacological modifications of insulin release in vitro from fuel-responsive transplantable insulinomas.
    Endocrinology, 1984, Volume: 115, Issue:4

    Topics: Acetylcholine; Adenoma, Islet Cell; Animals; Blood Glucose; Glucagon; Glucose; Insulin; Insulinoma;

1984
Return of beta-adrenergic sensitivity in a patient with insulinoma after removal of the tumour.
    Diabetic medicine : a journal of the British Diabetic Association, 1997, Volume: 14, Issue:11

    Topics: Adrenergic beta-Agonists; Adult; Blood Glucose; Epinephrine; Glucagon; Human Growth Hormone; Humans;

1997
Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells.
    Diabetologia, 1998, Volume: 41, Issue:12

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Blotting, Northern; Cyclic AMP; Glucagon; G

1998
The effects of amylin on insulin secretion from Rin m5F cells and glycogen synthesis and lipogenesis in rat primary cultured hepatocytes.
    Diabetes research and clinical practice, 1992, Volume: 15, Issue:1

    Topics: Acetates; Amyloid; Animals; Arginine; Blood Glucose; Cell Line; Cells, Cultured; Colforsin; Cyclic A

1992
The effect of somatostatin on 5-hydroxytryptamine release from a carcinoid tumor.
    Surgery, 1990, Volume: 108, Issue:6

    Topics: Acetylcholine; Carcinoid Tumor; Humans; Isoproterenol; Octreotide; Pancreatic Neoplasms; Pentagastri

1990
P19, a hormonally regulated phosphoprotein of peptide hormone-producing cells: secretagogue-induced phosphorylation in AtT-20 mouse pituitary tumor cells and in rat and hamster insulinoma cells.
    Endocrinology, 1986, Volume: 119, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenoma, Islet Cell; Adrenocort

1986