Page last updated: 2024-10-29

isoproterenol and Brugada Syndrome

isoproterenol has been researched along with Brugada Syndrome in 31 studies

Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.

Brugada Syndrome: An autosomal dominant defect of cardiac conduction that is characterized by an abnormal ST-segment in leads V1-V3 on the ELECTROCARDIOGRAM resembling a right BUNDLE-BRANCH BLOCK; high risk of VENTRICULAR TACHYCARDIA; or VENTRICULAR FIBRILLATION; SYNCOPAL EPISODE; and possible sudden death. This syndrome is linked to mutations of gene encoding the cardiac SODIUM CHANNEL alpha subunit.

Research Excerpts

ExcerptRelevanceReference
"Isoproterenol (ISP), a beta-adrenergic agonist, suppresses arrhythmic storm in patients with sporadic Brugada syndrome (BS)."7.78Effects of isoproterenol and propranolol on the inducibility and frequency of ventricular fibrillation in patients with Brugada syndrome. ( Doi, M; Fukuda, M; Hiratsuka, A; Matsuzaki, M; Omiya, T; Shimizu, A; Ueyama, T; Yoshida, M; Yoshiga, Y, 2012)
"Isoproterenol (ISP), a beta-adrenergic agonist, suppresses arrhythmic storm in patients with sporadic Brugada syndrome (BS)."3.78Effects of isoproterenol and propranolol on the inducibility and frequency of ventricular fibrillation in patients with Brugada syndrome. ( Doi, M; Fukuda, M; Hiratsuka, A; Matsuzaki, M; Omiya, T; Shimizu, A; Ueyama, T; Yoshida, M; Yoshiga, Y, 2012)
"No mouse showed ventricular arrhythmias in all of the 4 groups."1.42[Combined transgenic inhibition of CaMKII and Ik1 on cardiac remodeling]. ( Cui, TP; Dai, M; Du, XL; Du, YM; Huang, Y; Li, JD; Shu, YW; Su, GH; Yao, YF; Zhang, JM, 2015)
"Isoproterenol infusion was effective as an acute treatment in suppressing electrical storm of VF and was successfully replaced with chronic oral medications."1.34Acute and chronic management in patients with Brugada syndrome associated with electrical storm of ventricular fibrillation. ( Aihara, N; Kamakura, S; Kurita, T; Noda, T; Ohe, T; Ohgo, T; Okamura, H; Satomi, K; Shimizu, W; Suyama, K, 2007)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199010 (32.26)18.7374
1990's0 (0.00)18.2507
2000's6 (19.35)29.6817
2010's13 (41.94)24.3611
2020's2 (6.45)2.80

Authors

AuthorsStudies
Kokawa, T1
Yamamoto, H1
Itoh, M1
Shimane, A1
Kawai, H1
Takaya, T1
Călburean, PA1
Pannone, L1
Sorgente, A1
Gauthey, A1
Monaco, C1
Strazdas, A1
Almorad, A1
Bisignani, A1
Bala, G1
Ramak, R1
Overeinder, I1
Ströker, E1
Pappaert, G1
Van Dooren, S1
de Ravel, T1
La Meir, M1
Brugada, P1
Sieira, J1
Chierchia, GB1
de Asmundis, C1
Kataoka, H1
Shimizu, A2
Omiya, T2
Ueyama, T2
Yoshiga, Y2
Doi, M2
Hiratsuka, A2
Fukuda, M2
Yoshida, M2
Matsuzaki, M2
Yano, M1
Vega, J1
Enríquez, A1
Vergara, I1
Frangini, P1
Baeza, M1
Millapán, I1
González, R1
Huang, Y1
Dai, M1
Du, YM1
Yao, YF1
Zhang, JM1
Su, GH1
Shu, YW1
Cui, TP1
Du, XL1
Li, JD1
Yang, Y2
Liu, W1
Lu, X1
Zhang, G1
He, J1
Hu, C1
Lin, YC1
Chen, CC1
Yang, CC1
Allocca, G1
Proclemer, A1
Nucifora, G1
Dall'Armellina, E1
Rebellato, L1
Nam, GB1
Ko, KH1
Kim, J1
Park, KM1
Rhee, KS1
Choi, KJ1
Kim, YH1
Antzelevitch, C1
Morita, H2
Zipes, DP1
Morita, ST1
Wu, J1
Maesato, A1
Higa, S1
Lin, YJ1
Chinen, I1
Ishigaki, S1
Yajima, M1
Masuzaki, H1
Chen, SA1
Roten, L1
Derval, N1
Sacher, F1
Pascale, P1
Scherr, D1
Komatsu, Y1
Ramoul, K1
Daly, M1
Denis, A1
Shah, AJ1
Hocini, M1
Jaïs, P1
Haïssaguerre, M1
Furniss, G1
Chinushi, M1
Iijima, K1
Sato, A1
Furushima, H1
LINENTHAL, AJ1
ZOLL, PM1
RIDDELL, DH1
SCHULL, LG1
FRIST, TF1
BAKER, TD1
SEKIYA, A1
VAUGHANWILLIAMS, EM1
KNOPP, A1
ROE, BB1
BRUNS, DL1
SURAWICZ, B1
CHLEBUS, H1
REEVES, JT1
GETTES, LS1
GROSSE-BROCKHOFF, F1
TAKAORI, M1
LOEHNING, RW1
MORTARI, A1
SIOLI, G1
LUCCHESI, BR1
Watanabe, A1
Fukushima Kusano, K1
Miura, D1
Sumida, W1
Hiramatsu, S1
Banba, K1
Nishii, N1
Nagase, S1
Nakamura, K1
Sakuragi, S1
Ohe, T2
Yodogawa, K1
Morita, N1
Kobayashi, Y1
Takayama, H1
Ohara, T1
Katoh, T1
Takano, T1
Ohgo, T1
Okamura, H1
Noda, T1
Satomi, K1
Suyama, K1
Kurita, T1
Aihara, N1
Kamakura, S1
Shimizu, W1
Shvilkin, A1
Joshi, S1
Raiszadeh, F1
Pierce, W1
Steinberg, JS1

Reviews

1 review available for isoproterenol and Brugada Syndrome

ArticleYear
[MEDICAL MEASURES IN HEART FIBRILLATION AND HEART ARREST].
    Verhandlungen der Deutschen Gesellschaft fur Kreislaufforschung, 1964, Volume: 30

    Topics: Arrhythmias, Cardiac; Atrial Fibrillation; Brugada Syndrome; Cardiac Conduction System Disease; Drug

1964

Trials

1 trial available for isoproterenol and Brugada Syndrome

ArticleYear
Impact of pacing and high-pass filter settings on ventricular bipolar electrograms in implantable cardioverter defibrillator systems. - Implication of predictors for inappropriate therapy caused by oversensing of repolarization electrograms-.
    Circulation journal : official journal of the Japanese Circulation Society, 2011, Volume: 75, Issue:9

    Topics: Adrenergic beta-Agonists; Adult; Brugada Syndrome; Defibrillators, Implantable; Electrocardiography;

2011

Other Studies

29 other studies available for isoproterenol and Brugada Syndrome

ArticleYear
Fever-Related Ventricular Fibrillation - Potential Adverse Effect of SARS-CoV-2 Vaccination in Patients With Brugada Syndrome.
    Circulation journal : official journal of the Japanese Circulation Society, 2022, Feb-25, Volume: 86, Issue:3

    Topics: Acetaminophen; Adult; Anti-Arrhythmia Agents; Antipyretics; Arrhythmias, Cardiac; Brugada Syndrome;

2022
Heart rate variability and microvolt T wave alternans changes during ajmaline test may predict prognosis in Brugada syndrome.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2023, Volume: 33, Issue:1

    Topics: Ajmaline; Arrhythmias, Cardiac; Brugada Syndrome; Electrocardiography; Heart Rate; Humans; Isoproter

2023
Effects of isoproterenol infusion on the ST segment and r' of the QRS complex in the right precordial leads of the Brugada-type electrocardiogram pattern.
    Journal of cardiology, 2013, Volume: 61, Issue:4

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Brugada Syndrome; Humans; Isoproterenol; Male

2013
Effects of isoproterenol infusion on the ST segment and r of the QRS complex in the right precordial leads of the Brugada-type electrocardiogram pattern--author's reply.
    Journal of cardiology, 2013, Volume: 61, Issue:4

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Brugada Syndrome; Humans; Isoproterenol; Male

2013
[Electrical storm in Brugada syndrome successfully treated with isoproterenol. Report of a case].
    Revista medica de Chile, 2013, Volume: 141, Issue:10

    Topics: Adrenergic beta-Agonists; Brugada Syndrome; Defibrillators, Implantable; Electrocardiography; Humans

2013
[Combined transgenic inhibition of CaMKII and Ik1 on cardiac remodeling].
    Sheng li xue bao : [Acta physiologica Sinica], 2015, Apr-25, Volume: 67, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Brugada Syndrome; Calcium-Calmodulin-Dependent Protein Kinase Type 2;

2015
[2-Methylthio-adenosine-5'-triphosphate inhibits ventricular arrhythmogenesis in rabbits with chronic heart failure].
    Zhonghua xin xue guan bing za zhi, 2015, Volume: 43, Issue:3

    Topics: Action Potentials; Adenosine Triphosphate; Animals; Brugada Syndrome; Cardiac Conduction System Dise

2015
Perioperative isoproterenol infusion in a patient with Brugada syndrome.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2017, Volume: 64, Issue:5

    Topics: Adult; Brugada Syndrome; Cardiotonic Agents; Electrocardiography; Emergency Medical Services; Humans

2017
Monomorphic ventricular tachycardia in 'Brugada syndrome': clinical case and literature review.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2008, Volume: 9, Issue:8

    Topics: Adrenergic beta-Agonists; Adult; Brugada Syndrome; Electrocardiography; Follow-Up Studies; Heart Rat

2008
Mode of onset of ventricular fibrillation in patients with early repolarization pattern vs. Brugada syndrome.
    European heart journal, 2010, Volume: 31, Issue:3

    Topics: Adult; Aged; Brugada Syndrome; Cardiac Pacing, Artificial; Cardiotonic Agents; Case-Control Studies;

2010
Genotype-phenotype correlation in tissue models of Brugada syndrome simulating patients with sodium and calcium channelopathies.
    Heart rhythm, 2010, Volume: 7, Issue:6

    Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Anti-Arrhythmia Agents; Body Surface Potential

2010
Effects of isoproterenol and propranolol on the inducibility and frequency of ventricular fibrillation in patients with Brugada syndrome.
    Journal of cardiology, 2012, Volume: 60, Issue:1

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Brugada Syndrome; Electrocardiog

2012
Heterogeneous response of J-wave syndromes to beta-adrenergic stimulation.
    Heart rhythm, 2012, Volume: 9, Issue:12

    Topics: Adrenergic beta-Agonists; Adult; Brugada Syndrome; Electrocardiography; Female; Follow-Up Studies; H

2012
Isoprenaline and quinidine to calm Brugada VF storm.
    BMJ case reports, 2012, Aug-13, Volume: 2012

    Topics: Adrenergic beta-Agonists; Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Humans; Isoproterenol; Ma

2012
Short-coupling premature ventricular complexes from the left ventricle triggered isoproterenol-resistant electrical storm in a patient with Brugada syndrome.
    Heart rhythm, 2013, Volume: 10, Issue:6

    Topics: Adult; Anti-Arrhythmia Agents; Bepridil; Brugada Syndrome; Cardiotonic Agents; Electrocardiography;

2013
Prevention of ventricular tachycardia and fibrillation by intravenous isoproterenol and epinephrine.
    Circulation, 1963, Volume: 27

    Topics: Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Epinephrine; Heart Block;

1963
Experience with pheochromocytoma in 21 patients: use of dichloroisoproterenol hydrochloride for cardiac arrhythmia.
    Annals of surgery, 1963, Volume: 157

    Topics: Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Dibucaine; Heart Conducti

1963
THE EFFECTS OF PRONETHALOL, DICHLOROISOPRENALINE AND DISOPYRAMIDE ON THE TOXICITY TO THE HEART OF OUABAIN AND ANAESTHETICS.
    British journal of pharmacology and chemotherapy, 1963, Volume: 21

    Topics: Anesthetics; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Brugada Syndrome; Cardiac

1963
[CLINICO-THERAPEUTIC EXPERIENCES WITH ALUPENT IN DEFECTS OF THE RHYTHM CENTER AND CONDUCTION SYSTEM OF THE HEART].
    Die Medizinische Welt, 1964, Jun-27, Volume: 26

    Topics: Adams-Stokes Syndrome; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Di

1964
THE ARTIFICIAL CARDIAC PACEMAKER. INDICATIONS FOR IMPLANTATION.
    California medicine, 1964, Volume: 101

    Topics: Adams-Stokes Syndrome; Arrhythmias, Cardiac; Atrioventricular Block; Bradycardia; Brugada Syndrome;

1964
INCREASE OF VENTRICULAR EXCITABILITY THRESHOLD BY HYPERPOTASSEMIA: POSSIBLE CAUSE OF INTERNAL PACEMAKER FAILURE.
    JAMA, 1965, Mar-29, Volume: 191

    Topics: Adams-Stokes Syndrome; Arrhythmias, Cardiac; Biomedical Research; Brugada Syndrome; Cardiac Conducti

1965
VENTRICULAR ARRHYTHMIAS DURING HALOTHANE ANAESTHESIA: EFFECT OF ISOPROTERENOL, AMINOPHYLLINE, AND EPHEDRINE.
    Canadian Anaesthetists' Society journal, 1965, Volume: 12

    Topics: Aminophylline; Anesthesia; Anesthesia, Inhalation; Animals; Arrhythmias, Cardiac; Brugada Syndrome;

1965
[RESEARCH ON TH EFFECT OF OXYTOCIN ON CARDIAC ARRHYTHMIA].
    Cor et vasa, 1965, Volume: 7

    Topics: Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Electrocardiography; Ephe

1965
The action of dichloroisoproterenol (DCI) and several other pharmacological agents upon the aconitine-induced ventricular arrhythmia in the isolated rabbit heart.
    The Journal of pharmacology and experimental therapeutics, 1962, Volume: 137

    Topics: Acetylcholine; Aconitine; Aconitum; Animals; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduct

1962
Low-dose isoproterenol for repetitive ventricular arrhythmia in patients with Brugada syndrome.
    European heart journal, 2006, Volume: 27, Issue:13

    Topics: Adrenergic beta-Agonists; Adult; Brugada Syndrome; Cardiotonic Agents; Female; Humans; Injections, I

2006
High-frequency potentials developed in wavelet-transformed electrocardiogram as a novel indicator for detecting Brugada syndrome.
    Heart rhythm, 2006, Volume: 3, Issue:12

    Topics: Action Potentials; Adrenergic beta-Agonists; Adult; Aged; Anti-Arrhythmia Agents; Brugada Syndrome;

2006
Acute and chronic management in patients with Brugada syndrome associated with electrical storm of ventricular fibrillation.
    Heart rhythm, 2007, Volume: 4, Issue:6

    Topics: Acute Disease; Adult; Aged; Brugada Syndrome; Chronic Disease; Death, Sudden, Cardiac; Female; Human

2007
Treatment of ventricular fibrillation storm in Brugada syndrome: weathering the storm but staying in hot water?
    Heart rhythm, 2007, Volume: 4, Issue:6

    Topics: Brugada Syndrome; Death, Sudden, Cardiac; Humans; Isoproterenol; Quinidine; Ventricular Fibrillation

2007
Antiarrhythmic induced electrical storm in Brugada syndrome: a case report.
    Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2007, Volume: 12, Issue:3

    Topics: Adrenergic beta-Agonists; Amiodarone; Anti-Arrhythmia Agents; Brugada Syndrome; Defibrillators, Impl

2007