isoproterenol has been researched along with Bronchial Hyperreactivity in 22 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Bronchial Hyperreactivity: Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intraperitoneal injection of endotoxin resulted in bronchial hyperreactivity to histamine in guinea pigs." | 3.69 | Effect of Apafant on bronchial hyperresponsiveness and down-regulation of beta-adrenoceptors induced by endotoxin in guinea pigs. ( Hayakawa, T; Kamei, C; Kishida, H; Mihara, T; Nakayama, Y; Sugimoto, Y, 1997) |
| "Treatment with indomethacin reduced IP response in the hyper-reactive model, and did not produce any change in diabetic model with hyper-reactive airways, indicating further disruption of the COX pathway." | 1.43 | Deterioration of epithelium mediated mechanisms in diabetic-antigen sensitized airways of guinea pigs. ( Bano, S; Kambadur, M; Mohammad, F; Swati, O, 2016) |
| "Ozone is a potent oxidizing agent with a variety of potential uses, including its antimicrobial and deodorising properties." | 1.34 | The pharmacological effects of ozone on isolated guinea pig tracheal preparations. ( Lotriet, CJ; Oliver, DW; Venter, DP, 2007) |
| "There are reports regarding harmful effect of long-term use of beta2-agonist drugs on asthma severity and airway responsiveness." | 1.33 | Influence of epithelium and isoprenaline incubation on responsiveness of guinea-pig trachea to methacholine. ( Aslani, MR; Boskabady, MH; Tabatabaei, A, 2006) |
| "In human non-smokers without airway obstruction, increased BAT was correlated with bronchial hyperreactivity." | 1.33 | Bronchial hyperreactivity is correlated with increased baseline airway tone. ( Bergner, A; Fischer, R; Gamarra, F; Huber, RM; Kellner, J; Kemp da Silva, A, 2006) |
| " infusion of each agonist by constructing cumulative dose-response curves from breath-by-breath measurements of the effect of different rates of i." | 1.29 | Enhancement of airway reactivity to histamine by isoprenaline and related beta-adrenoceptor agonists in the guinea-pig. ( Blackman, JG; Galland, BC, 1993) |
| " Pretreatment of muscle strips from BG dogs with isoproterenol had no effect on subsequent dose-response curves to methacholine (pD2 = 7." | 1.29 | Impaired beta-adrenergic receptor activation of adenylyl cyclase in airway smooth muscle in the basenji-greyhound dog model of airway hyperresponsiveness. ( Black, C; Curry, C; Emala, C; Hirshman, CA; Levine, MA, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 11 (50.00) | 18.2507 |
| 2000's | 9 (40.91) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bano, S | 1 |
| Swati, O | 1 |
| Kambadur, M | 1 |
| Mohammad, F | 1 |
| Long, JW | 1 |
| Yang, XD | 1 |
| Cao, L | 1 |
| Lu, SM | 1 |
| Cao, YX | 1 |
| Joos, L | 1 |
| Weir, TD | 1 |
| Connett, JE | 1 |
| Anthonisen, NR | 1 |
| Woods, R | 1 |
| Paré, PD | 1 |
| Sandford, AJ | 1 |
| Boskabady, MH | 2 |
| Zarei, A | 1 |
| Que, LG | 1 |
| Liu, L | 1 |
| Yan, Y | 1 |
| Whitehead, GS | 1 |
| Gavett, SH | 2 |
| Schwartz, DA | 1 |
| Stamler, JS | 1 |
| Gerard, C | 1 |
| Hansen, EF | 1 |
| Vestbo, J | 1 |
| Aslani, MR | 1 |
| Tabatabaei, A | 1 |
| Bergner, A | 1 |
| Kellner, J | 1 |
| Kemp da Silva, A | 1 |
| Fischer, R | 1 |
| Gamarra, F | 1 |
| Huber, RM | 1 |
| Lotriet, CJ | 1 |
| Oliver, DW | 1 |
| Venter, DP | 1 |
| Dooper, MW | 1 |
| Timmermans, A | 2 |
| Weersink, EJ | 1 |
| De Monchy, JG | 2 |
| Kauffman, HF | 2 |
| Mazzoni, L | 1 |
| Naef, R | 1 |
| Chapman, ID | 1 |
| Morley, J | 2 |
| Chen, JX | 1 |
| Wu, HX | 1 |
| Wang, Y | 1 |
| Santing, RE | 1 |
| Schraa, EO | 1 |
| Vos, BG | 1 |
| Gores, RJ | 1 |
| Olymulder, CG | 1 |
| Meurs, H | 2 |
| Zaagsma, J | 2 |
| Galland, BC | 1 |
| Blackman, JG | 1 |
| Wills-Karp, M | 1 |
| Emala, C | 1 |
| Black, C | 1 |
| Curry, C | 1 |
| Levine, MA | 1 |
| Hirshman, CA | 2 |
| van Hoof, HJ | 1 |
| Voss, HP | 1 |
| Kramer, K | 1 |
| Boere, AJ | 1 |
| Dormans, JA | 1 |
| van Bree, L | 1 |
| Bast, A | 1 |
| Sugimoto, Y | 1 |
| Mihara, T | 1 |
| Hayakawa, T | 1 |
| Nakayama, Y | 1 |
| Kishida, H | 1 |
| Kamei, C | 1 |
| Downes, H | 1 |
| Austin, DR | 1 |
| Parks, CM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methods to Identify and Treat Severe Asthma Patients Project 1: GSNOR Phenotyping and GSNO Challenge[NCT03926741] | Early Phase 1 | 60 participants (Anticipated) | Interventional | 2019-04-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
22 other studies available for isoproterenol and Bronchial Hyperreactivity
| Article | Year |
|---|---|
Deterioration of epithelium mediated mechanisms in diabetic-antigen sensitized airways of guinea pigs.
Topics: Acetylcholine; Animals; Antigens, Bacterial; Bacterial Proteins; Bronchial Hyperreactivity; Bronchoc | 2016 |
Alteration of airway responsiveness mediated by receptors in ovalbumin-induced asthmatic E3 rats.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchodilator Agents; Dose-Response Relationship, Drug; | 2009 |
Polymorphisms in the beta2 adrenergic receptor and bronchodilator response, bronchial hyperresponsiveness, and rate of decline in lung function in smokers.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Asthma; Bronchial Hyperreactivity; Bronchocons | 2003 |
Increased tracheal responsiveness to beta-adrenergic agonist and antagonist in ovalbumin-sensitized guinea pigs.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aerosols; Animals | 2004 |
Protection from experimental asthma by an endogenous bronchodilator.
Topics: Adrenergic beta-Agonists; Alcohol Dehydrogenase; Allergens; Animals; Asthma; Bronchi; Bronchial Hype | 2005 |
Biomedicine. Asthmatics breathe easier when it's SNO-ing.
Topics: Adrenergic beta-Agonists; Alcohol Dehydrogenase; Animals; Asthma; Bronchi; Bronchial Hyperreactivity | 2005 |
Bronchodilator reversibility in COPD: the roguish but harmless little brother of airway hyperresponsiveness?
Topics: Aged; Bronchial Hyperreactivity; Bronchodilator Agents; Comorbidity; Female; Forced Expiratory Volum | 2005 |
Influence of epithelium and isoprenaline incubation on responsiveness of guinea-pig trachea to methacholine.
Topics: Adrenergic beta-Agonists; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bro | 2006 |
Bronchial hyperreactivity is correlated with increased baseline airway tone.
Topics: Acetylcholine; Airway Obstruction; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Bronc | 2006 |
The pharmacological effects of ozone on isolated guinea pig tracheal preparations.
Topics: Animals; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Dose-Response | 2007 |
Defect in potentiation of adenylyl cyclase correlates with bronchial hyperreactivity.
Topics: Adenylyl Cyclases; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodil | 1995 |
Hyperresponsiveness of the airways following exposure of guinea-pigs to racemic mixtures and distomers of beta 2-selective sympathomimetics.
Topics: Administration, Topical; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Airway Resis | 1994 |
[The role of endotoxin in the bronchial hyperreactivity formation].
Topics: Animals; Bronchial Hyperreactivity; Endotoxins; Escherichia coli; Guinea Pigs; Histamine; In Vitro T | 1994 |
Dissociation between bronchial hyperreactivity in vivo and reduced beta-adrenoceptor sensitivity in vitro in allergen-challenged guinea pigs.
Topics: Allergens; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage F | 1994 |
Enhancement of airway reactivity to histamine by isoprenaline and related beta-adrenoceptor agonists in the guinea-pig.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Bronchi; Bronchial Hyperreactivity; Epinephrine; Guine | 1993 |
Elevated lung G protein levels and muscarinic receptor affinity in a mouse model of airway hyperreactivity.
Topics: Animals; Binding, Competitive; Bronchial Hyperreactivity; Cell Membrane; Dihydroalprenolol; Disease | 1993 |
Lack of coupling of muscarinic receptors to phosphoinositide metabolism and adenylyl cyclase in human lymphocytes and polymorphonuclear leukocytes: studies in healthy subjects and allergic asthmatic patients.
Topics: Adenylyl Cyclases; Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Cyclic AMP; Female; Humans; | 1993 |
Impaired beta-adrenergic receptor activation of adenylyl cyclase in airway smooth muscle in the basenji-greyhound dog model of airway hyperresponsiveness.
Topics: Adenylyl Cyclases; Analysis of Variance; Animals; Bronchial Hyperreactivity; Bucladesine; Cholera To | 1993 |
Changes in neuroreceptor function of tracheal smooth muscle following acute ozone exposure of guinea pigs.
Topics: Animals; Bronchial Hyperreactivity; Epithelium; Guinea Pigs; Isoproterenol; Male; Methacholine Chlor | 1997 |
Effect of Apafant on bronchial hyperresponsiveness and down-regulation of beta-adrenoceptors induced by endotoxin in guinea pigs.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Azepines; Binding Sites; Bronchial H | 1997 |
Asthma mortality and inhaled beta agonist therapy.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Asthma; Bronchial Hyperreactivity; Guinea Pigs; Humans | 1992 |
Comparison of in vitro drug responses in airways of atopic dogs with and without in vivo airway hyperresponsiveness.
Topics: Aerosols; Animals; Bronchial Hyperreactivity; Dogs; Hypersensitivity, Immediate; Isoproterenol; Meth | 1989 |