isoproterenol has been researched along with Autoimmune Diabetes in 36 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "beta-Adrenergic sensitivity was measured by isoproterenol testing before and at 2 and 4 months after strict avoidance of hypoglycemia." | 5.09 | Avoidance of hypoglycemia restores hypoglycemia awareness by increasing beta-adrenergic sensitivity in type 1 diabetes. ( Fritsche, A; Gerich, J; Häring, H; Stefan, N; Stumvoll, M, 2001) |
| "The sensitivity of components of the adenylate cyclase signaling system (heterotrimer G proteins and adenylate cyclase enzyme) to the regulatory effects of hormones mediated through G proteins (stimulatory effect of isoproterenol and relaxin and inhibitory effects of somatostatin) was decreased in the myocardium of hyperglycemic rats under conditions of transitory hyperglycemia caused by intravenous glucose and in hyperglycemia associated with insulin insufficiency in 24-h type 1 streptozotocin-induced diabetes mellitus." | 3.74 | Functional coupling of hormone receptors with G proteins in the adenylate cyclase system of the rat muscle tissues and brain under conditions of short-term hyperglycemia. ( Bondareva, VM; Kuznetsova, LA; Pertseva, MN; Plesneva, SA; Shpakov, AO, 2007) |
| " The dose-response curve of isoprenaline/HR was significantly shifted to the right after hypoglycemia." | 2.68 | Reduced beta-adrenergic sensitivity in healthy volunteers induced by hypoglycemia. ( Jaeger, R; Jorde, R; Sager, G; Trovik, TS, 1995) |
| "Metoprolol was given together with the dose of isoprenaline which increased heart rate by 25 beats min-1." | 2.67 | Reduced sensitivity to beta-adrenoceptor stimulation and blockade in insulin dependent diabetic patients with hypoglycaemia unawareness. ( Jaeger, R; Jorde, R; Sager, G; Trovik, TS, 1994) |
| "Type 1 diabetes was induced in male Sprague-Dawley rats using streptozotocin." | 1.35 | Exercise training initiated after the onset of diabetes preserves myocardial function: effects on expression of beta-adrenoceptors. ( Bidasee, KR; Parbhu, SK; Patel, KP; Rozanski, GJ; Shao, CH; Zheng, H, 2008) |
| "When glycosuria is high (20 to 500 mg/dL), there is a selective reduction in the response to alpha1 and beta2 agonists but not to dopamine or serotonin." | 1.32 | Diabetic mouse angiopathy is linked to progressive sympathetic receptor deletion coupled to an enhanced caveolin-1 expression. ( Brancaleone, V; Bucci, M; Cicala, C; Cirino, G; Di Lorenzo, A; Farneti, S; Fiorucci, S; Lin, MI; Pinto, A; Roviezzo, F; Sessa, WC, 2004) |
| "A total of 21 subjects with type 1 diabetes underwent a standardized insulin infusion protocol to produce a stepwise decrease in plasma glucose to 45-min plateaus of 4." | 1.30 | Reduced beta-adrenergic sensitivity in patients with type 1 diabetes and hypoglycemia unawareness. ( Cryer, PE; Gerich, JE; Korytkowski, MT; Mitrakou, A; Mokan, M; Veneman, TF, 1998) |
| "To determine if patients with IDDM have increased sensitivity of cellular beta 2-adrenergic receptor-effector systems, we assessed beta 2-adrenergic receptors and adenylate cyclase sensitivities to isoproterenol in partially purified mononuclear leukocyte (MNL) plasma membranes from 10 patients with IDDM (without adrenergic neuropathy) and 10 matched nondiabetic controls." | 1.27 | Mononuclear leukocyte beta 2-adrenergic receptors and adenylate cyclase sensitivity in insulin-dependent diabetes mellitus. ( Clutter, WE; Cryer, PE; Rosen, SG; Sérusclat, P; Shah, SD; Smith, EB, 1983) |
| "Isoproterenol was only taken up by a non-neuronal uptake; this finding may indicate that neuronal uptake is not important for the inactivation of circulating catecholamines." | 1.27 | Noradrenaline and isoproterenol kinetics in diabetic patients with and without autonomic neuropathy. ( Christensen, NJ; Dejgaard, A; Hilsted, J, 1986) |
| " The dose-response curve of renin secretion (as a proportion of total renal content) in response to isoproterenol was shifted downward." | 1.27 | Renin secretion by the spontaneously diabetic rat. ( Cohen, AJ; McCarthy, DM; Rossetti, RR, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (36.11) | 18.7374 |
| 1990's | 15 (41.67) | 18.2507 |
| 2000's | 5 (13.89) | 29.6817 |
| 2010's | 3 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmad, S | 1 |
| Giannopoulou, A | 1 |
| Owen, P | 1 |
| Kalhan, A | 1 |
| Shpakov, AO | 2 |
| Derkach, KV | 1 |
| Chistiakova, OV | 1 |
| Moĭseiuk, IV | 1 |
| Bondareva, VM | 2 |
| Kikuchi, C | 1 |
| Bienengraeber, M | 1 |
| Canfield, S | 1 |
| Koopmeiner, A | 1 |
| Schäfer, R | 1 |
| Bosnjak, ZJ | 1 |
| Bai, X | 1 |
| Bidasee, KR | 1 |
| Zheng, H | 1 |
| Shao, CH | 1 |
| Parbhu, SK | 1 |
| Rozanski, GJ | 1 |
| Patel, KP | 1 |
| Kuznetsova, LA | 1 |
| Plesneva, SA | 1 |
| Pertseva, MN | 1 |
| Bucci, M | 1 |
| Roviezzo, F | 1 |
| Brancaleone, V | 1 |
| Lin, MI | 1 |
| Di Lorenzo, A | 1 |
| Cicala, C | 1 |
| Pinto, A | 1 |
| Sessa, WC | 1 |
| Farneti, S | 1 |
| Fiorucci, S | 1 |
| Cirino, G | 1 |
| Sérusclat, P | 1 |
| Rosen, SG | 1 |
| Smith, EB | 1 |
| Shah, SD | 1 |
| Clutter, WE | 1 |
| Cryer, PE | 3 |
| Wingard, LB | 1 |
| Arner, P | 3 |
| Engfeldt, P | 3 |
| Ostman, J | 2 |
| Trovik, TS | 4 |
| Jaeger, R | 2 |
| Jorde, R | 3 |
| Sager, G | 4 |
| Silbiger, SR | 1 |
| Cohen, AJ | 2 |
| Fishman, JB | 1 |
| Stoff, JS | 1 |
| Schwab, KO | 1 |
| Bartels, H | 1 |
| Martin, C | 1 |
| Leichtenschlag, EM | 1 |
| Katovich, MJ | 1 |
| Marks, KS | 1 |
| Sninsky, CA | 1 |
| Vaartun, A | 2 |
| Zierath, JR | 1 |
| Handberg, A | 1 |
| Tally, M | 1 |
| Wallberg-Henriksson, H | 1 |
| Bányász, T | 1 |
| Kalapos, I | 1 |
| Kelemen, SZ | 1 |
| Kovács, T | 1 |
| Schmetterer, L | 1 |
| Findl, O | 1 |
| Strenn, K | 1 |
| Fasching, P | 1 |
| Zanaschka, G | 1 |
| Eichler, HG | 1 |
| Wolzt, M | 1 |
| Fritsche, A | 3 |
| Stumvoll, M | 3 |
| Grüb, M | 1 |
| Sieslack, S | 1 |
| Renn, W | 1 |
| Schmülling, RM | 1 |
| Häring, HU | 2 |
| Gerich, JE | 3 |
| Korytkowski, MT | 1 |
| Mokan, M | 1 |
| Veneman, TF | 1 |
| Mitrakou, A | 1 |
| Stefan, N | 1 |
| Häring, H | 1 |
| Gerich, J | 1 |
| Dejgaard, A | 2 |
| Liggett, SB | 1 |
| Christensen, NJ | 2 |
| Hilsted, J | 2 |
| Maraud, L | 1 |
| Gin, H | 1 |
| Roudaut, R | 1 |
| Aubertin, J | 1 |
| Bricaud, H | 1 |
| Wolf, JP | 1 |
| Massol, J | 1 |
| Nguyen, NU | 1 |
| Berthelay, S | 1 |
| Wahrenberg, H | 1 |
| Lönnqvist, F | 1 |
| Tatoń, J | 1 |
| Czech, A | 1 |
| Laz, R | 1 |
| Krone, W | 1 |
| Naegele, H | 1 |
| Behnke, B | 1 |
| Greten, H | 1 |
| Berlin, I | 2 |
| Grimaldi, A | 2 |
| Bosquet, F | 2 |
| Puech, AJ | 1 |
| Gøtzsche, O | 1 |
| McCarthy, DM | 1 |
| Rossetti, RR | 1 |
| Puech, A | 1 |
| Loggie, JM | 1 |
| Van Maanen, EF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ethnic Dependence of the Metabolic Defects in Prediabetic Individuals: Kuwaiti Arabs Versus Indians[NCT04268862] | 120 participants (Anticipated) | Observational | 2020-03-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for isoproterenol and Autoimmune Diabetes
| Article | Year |
|---|---|
Immobilized drugs and enzymes in biochemical pharmacology. Perspectives and critique.
Topics: Alprenolol; Animals; Blood Glucose; Cell Membrane; Diabetes Mellitus, Type 1; Enzymes, Immobilized; | 1983 |
Early abnormalities in myocardial cell function in experimental diabetes.
Topics: Adenosine Triphosphate; Adult; Animals; Blood Glucose; Calcium; Calcium-Transporting ATPases; Catech | 1986 |
The autonomic nervous system and some aspects of the use of autonomic drugs in children. II.
Topics: Adrenergic beta-Antagonists; Aortic Valve Stenosis; Asthma; Autonomic Agents; Bronchitis; Cardiomyop | 1972 |
3 trials available for isoproterenol and Autoimmune Diabetes
| Article | Year |
|---|---|
Reduced beta-adrenergic sensitivity in healthy volunteers induced by hypoglycemia.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Dose-Response Relationship, Drug; Humans; Hypoglyce | 1995 |
Reduced sensitivity to beta-adrenoceptor stimulation and blockade in insulin dependent diabetic patients with hypoglycaemia unawareness.
Topics: Adult; Analysis of Variance; Awareness; Blood Glucose; Blood Pressure; Chromatography, High Pressure | 1994 |
Avoidance of hypoglycemia restores hypoglycemia awareness by increasing beta-adrenergic sensitivity in type 1 diabetes.
Topics: Adult; Analysis of Variance; Blood Glucose; Diabetes Mellitus, Type 1; Epinephrine; Glucose Clamp Te | 2001 |
30 other studies available for isoproterenol and Autoimmune Diabetes
| Article | Year |
|---|---|
Polyglandular endocrine emergency: lessons from a patient, which a book cannot teach.
Topics: Addison Disease; Adrenergic beta-Agonists; Adult; Anti-Inflammatory Agents; Celiac Disease; Diabetes | 2018 |
[The influence of long-term diabetes mellitus induced by streptozotocin treatment of six-week rats on the functional activity of adenylyl cyclase system].
Topics: Adenylyl Cyclases; Adolescent; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adult; Animals; | 2013 |
Comparison of Cardiomyocyte Differentiation Potential Between Type 1 Diabetic Donor- and Nondiabetic Donor-Derived Induced Pluripotent Stem Cells.
Topics: Action Potentials; Adrenergic beta-Agonists; Biomarkers; Cell Differentiation; Cell- and Tissue-Base | 2015 |
Exercise training initiated after the onset of diabetes preserves myocardial function: effects on expression of beta-adrenoceptors.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blotting, Western; Diabetes Mellitus | 2008 |
Functional coupling of hormone receptors with G proteins in the adenylate cyclase system of the rat muscle tissues and brain under conditions of short-term hyperglycemia.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Brain; Cells; Cyclic AMP; Diabetes Mellitus, Typ | 2007 |
Diabetic mouse angiopathy is linked to progressive sympathetic receptor deletion coupled to an enhanced caveolin-1 expression.
Topics: Adrenergic beta-Agonists; Animals; Aorta; Cattle; Caveolin 1; Caveolins; Cell Line; Diabetes Mellitu | 2004 |
Mononuclear leukocyte beta 2-adrenergic receptors and adenylate cyclase sensitivity in insulin-dependent diabetes mellitus.
Topics: Adenylyl Cyclases; Adult; Autonomic Nervous System; Blood Pressure; Cell Membrane; Diabetes Mellitus | 1983 |
Blood glucose control and lipolysis in diabetes mellitus.
Topics: Adipose Tissue; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Glycerol; Humans; Insul | 1980 |
Defective glomerular beta-adrenergic signal transmission in spontaneously diabetic rats.
Topics: Animals; Blood Glucose; Colforsin; Cyclic AMP; Diabetes Mellitus, Type 1; Dinoprostone; Histamine; I | 1994 |
Decreased beta 2-adrenoceptor density and decreased isoproterenol induced c-AMP increase in juvenile type I diabetes mellitus: an additional cause of severe hypoglycaemia in childhood diabetes?
Topics: Adolescent; Adult; Child; Child, Preschool; Cyclic AMP; Diabetes Mellitus, Type 1; Granulocytes; Hum | 1993 |
Effect of insulin on the altered thyroid function and adrenergic responsiveness in the diabetic rat.
Topics: Animals; Body Temperature Regulation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; In | 1993 |
Altered cAMP response after isoprenaline stimulation of mononuclear leucocytes from insulin-dependent diabetic patients with hypoglycaemia unawareness.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Analysis of Variance; Binding, Competitive; C | 1995 |
Dysfunction in the beta 2-adrenergic signal pathway in patients with insulin dependent diabetes mellitus (IDDM) and unawareness of hypoglycaemia.
Topics: Adrenergic beta-Agonists; Adult; Binding, Competitive; Diabetes Mellitus, Type 1; Female; Humans; Hy | 1995 |
C-peptide stimulates glucose transport in isolated human skeletal muscle independent of insulin receptor and tyrosine kinase activation.
Topics: 3-O-Methylglucose; Adrenergic beta-Agonists; Adult; Biological Transport; Biopsy; Bucladesine; C-Pep | 1996 |
Changes in cardiac contractility in IDDM and NIDDM diabetic rats.
Topics: Animals; Cardiotonic Agents; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Me | 1996 |
Ocular and systemic reactivity to isoprenaline in patients with insulin-dependent diabetes mellitus.
Topics: Adrenergic beta-Agonists; Adult; Blood Pressure; Diabetes Mellitus, Type 1; Eye; Fundus Oculi; Hemod | 1997 |
Effect of hypoglycemia on beta-adrenergic sensitivity in normal and type 1 diabetic subjects.
Topics: Adrenergic beta-Agonists; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Epinephrine; Female; Gluc | 1998 |
Reduced beta-adrenergic sensitivity in patients with type 1 diabetes and hypoglycemia unawareness.
Topics: Adrenergic beta-Agonists; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Epinephrine; Female; Hear | 1998 |
Reversal of hypoglycemia unawareness in a long-term type 1 diabetic patient by improvement of beta-adrenergic sensitivity after prevention of hypoglycemia.
Topics: Adrenergic beta-Agonists; Adult; Awareness; Blood Glucose; Chronic Disease; Diabetes Mellitus, Type | 2000 |
Relationship between lipolysis, cyclic AMP, and fat-cell size in human adipose tissue during fasting and in diabetes mellitus.
Topics: Adipose Tissue; Adult; Cyclic AMP; Diabetes Mellitus; Diabetes Mellitus, Type 1; Fasting; Female; Hu | 1979 |
Adrenergic receptors are a fallible index of adrenergic denervation hypersensitivity.
Topics: Adult; Cell Membrane; Cyclic AMP; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Epinephrine; Hum | 1991 |
Echocardiographic study of left ventricular function in type 1 diabetes mellitus: hypersensitivity of beta-adrenergic stimulation.
Topics: Adult; Blood Pressure; Diabetes Mellitus, Type 1; Echocardiography; Female; Heart; Heart Rate; Heart | 1991 |
Arginine vasopressin response to insulin-induced hypoglycemia in insulin-dependent diabetics with asymptomatic hypoglycemia.
Topics: Adult; Arginine Vasopressin; Diabetes Mellitus, Type 1; Epinephrine; Female; Heart Rate; Humans; Hyd | 1990 |
Abnormal action of catecholamines on lipolysis in adipocytes of type I diabetic patients treated with insulin.
Topics: Adipose Tissue; Adult; Cells, Cultured; Diabetes Mellitus, Type 1; Epinephrine; Humans; Insulin; Iso | 1989 |
[Evaluation of the reactivity of the adrenergic system using the isoproterenol test in diabetes mellitus type 1].
Topics: Adult; Blood Pressure; Diabetes Mellitus, Type 1; Female; Heart Rate; Humans; Isoproterenol; Male; R | 1987 |
Opposite effects of insulin and catecholamines on LDL-receptor activity in human mononuclear leukocytes.
Topics: Catecholamines; Diabetes Mellitus, Type 1; Epinephrine; Humans; In Vitro Techniques; Insulin; Isopro | 1988 |
Decreased beta-adrenergic sensitivity in insulin-dependent diabetic subjects.
Topics: Adult; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Female; Glycated Hemoglobin; Heart Rate; Hu | 1986 |
Noradrenaline and isoproterenol kinetics in diabetic patients with and without autonomic neuropathy.
Topics: Adult; Autonomic Nervous System Diseases; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Neuropa | 1986 |
Renin secretion by the spontaneously diabetic rat.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diet, Sodium-Restricted; Dose-R | 1986 |
[Counterregulatory hormone response to insulin-induced hypoglycemia in insulin-dependent diabetics].
Topics: Adult; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Heart Rate; Humans; Isoproterenol | 1986 |