isoproterenol has been researched along with Alzheimer Disease in 29 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Time course of candidate gene expression following adrenergic stimulation with isoproterenol was assayed in neuroblastoma cells by quantitative reverse transcription (RT)-PCR." | 3.73 | Association of DSC1, a gene modulated by adrenergic stimulation, with Alzheimer's disease. ( Bullido, MJ; Frank, A; Martínez-García, A; Ramos, MC; Rosich-Estragó, M; Sastre, I; Tenorio, R; Valdivieso, F; Vilella-Cuadrada, E, 2006) |
| "To explore the correlation between cerebral functional alterations revealed by functional magnetic resonance imaging (fMRI) and Alzheimer disease- (AD)-like tau hyperphosphorylation, we injected bilaterally 2 microl each of 20 mM isoproterenol (IP), a PKA activator, or of saline as a vehicle control into the hippocampus of rats." | 3.72 | Correlation of Alzheimer-like tau hyperphosphorylation and fMRI bold intensity. ( Jian-Zhi, W; Qun, W; Xiao-Chuan, W; Xiao-Wei, T; Yi-Gen, W; Yue, F; Yun-Huang, Y; Zheng-Hui, H; Zheng-Yu, F, 2004) |
| "Caring for a spouse with Alzheimer's disease (AD) is associated with overall health decline and impaired cardiovascular functioning." | 1.35 | A 5-year longitudinal study of the relationships between stress, coping, and immune cell beta(2)-adrenergic receptor sensitivity. ( Ancoli-Israel, S; Aschbacher, K; Dimsdale, JE; Grant, I; Mausbach, BT; Mills, PJ; Patterson, TL; Roepke, SK; von Känel, R; Ziegler, MG, 2008) |
| "Previous studies have shown that in Alzheimer's disease post-mortem brain there are disruptions of both beta1-adrenoceptor-G-protein coupling and G-protein stimulation of adenylyl cyclase activity." | 1.30 | Decreased beta-adrenoceptor-stimulated adenylyl cyclase activity in lymphocytes from Alzheimer's disease patients. ( Algotsson, A; Cowburn, RF; Garlind, A; Johnston, JA; Winblad, B, 1997) |
| "The effects of Alzheimer's disease (AD) on [35S]GTP gamma S binding to G proteins was examined in postmortem cerebrocortex." | 1.29 | Receptor-mediated activation of G proteins is reduced in postmortem brains from Alzheimer's disease patients. ( Friedman, E; Wang, HY, 1994) |
| "Further, any hypothesis about Alzheimer's disease must explain why a reduced beta-adrenergic-stimulated cAMP formation persists in tissue culture." | 1.29 | Altered beta-adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors. ( Gibson, GE; Huang, HM, 1993) |
| "L-Carnitine was tested as a potential therapeutic agent, since it has been used to treat a variety of experimental metabolic encephalopathies." | 1.28 | Cultured cells as a screen for novel treatments of Alzheimer's disease. ( Baker, AC; Blass, JP; Malow, BA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (20.69) | 18.7374 |
| 1990's | 8 (27.59) | 18.2507 |
| 2000's | 13 (44.83) | 29.6817 |
| 2010's | 2 (6.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Soeda, Y | 1 |
| Yoshikawa, M | 1 |
| Almeida, OF | 1 |
| Sumioka, A | 1 |
| Maeda, S | 1 |
| Osada, H | 1 |
| Kondoh, Y | 1 |
| Saito, A | 1 |
| Miyasaka, T | 1 |
| Kimura, T | 1 |
| Suzuki, M | 1 |
| Koyama, H | 1 |
| Yoshiike, Y | 1 |
| Sugimoto, H | 1 |
| Ihara, Y | 1 |
| Takashima, A | 1 |
| Misra, S | 1 |
| Chopra, K | 1 |
| Saikia, UN | 1 |
| Sinha, VR | 1 |
| Sehgal, R | 1 |
| Modi, M | 1 |
| Medhi, B | 1 |
| Mausbach, BT | 2 |
| Aschbacher, K | 2 |
| Mills, PJ | 2 |
| Roepke, SK | 1 |
| von Känel, R | 2 |
| Patterson, TL | 2 |
| Dimsdale, JE | 2 |
| Ziegler, MG | 1 |
| Ancoli-Israel, S | 2 |
| Grant, I | 2 |
| Takaya, T | 1 |
| Okamoto, M | 1 |
| Yodoi, K | 1 |
| Hata, K | 1 |
| Kijima, Y | 1 |
| Nakajima, H | 1 |
| Nishikawa, Y | 1 |
| Kita, T | 1 |
| Ito, M | 1 |
| Seo, T | 1 |
| Kawashima, S | 1 |
| Wang, DL | 1 |
| Ling, ZQ | 1 |
| Cao, FY | 1 |
| Zhu, LQ | 1 |
| Wang, JZ | 3 |
| Hu, ZH | 1 |
| Wang, XC | 2 |
| Li, LY | 1 |
| Liu, ML | 1 |
| Liu, R | 1 |
| Ling, Z | 1 |
| Tian, Q | 1 |
| Tang, XW | 1 |
| Wu, YG | 1 |
| Sun, L | 1 |
| Wang, X | 1 |
| Liu, S | 1 |
| Wang, Q | 1 |
| Wang, J | 1 |
| Bennecib, M | 1 |
| Gong, CX | 1 |
| Sengupta, A | 2 |
| Grundke-Iqbal, I | 2 |
| Iqbal, K | 2 |
| Zhang, J | 1 |
| Yu, X | 1 |
| Han, L | 1 |
| Zhou, ZT | 1 |
| Zhang, Y | 1 |
| Xiao-Chuan, W | 1 |
| Zheng-Hui, H | 1 |
| Zheng-Yu, F | 1 |
| Yue, F | 1 |
| Yun-Huang, Y | 1 |
| Qun, W | 1 |
| Xiao-Wei, T | 1 |
| Yi-Gen, W | 1 |
| Jian-Zhi, W | 1 |
| Kalinin, S | 1 |
| Gavrilyuk, V | 1 |
| Polak, PE | 1 |
| Vasser, R | 1 |
| Zhao, J | 1 |
| Heneka, MT | 1 |
| Feinstein, DL | 1 |
| Ramos, MC | 1 |
| Tenorio, R | 1 |
| Martínez-García, A | 1 |
| Sastre, I | 1 |
| Vilella-Cuadrada, E | 1 |
| Frank, A | 1 |
| Rosich-Estragó, M | 1 |
| Valdivieso, F | 1 |
| Bullido, MJ | 1 |
| Bisel, BE | 1 |
| Henkins, KM | 1 |
| Parfitt, KD | 1 |
| Oppenheim, G | 2 |
| Mintzer, J | 1 |
| Halperin, Y | 1 |
| Eliakim, R | 1 |
| Stessman, J | 2 |
| Ebstein, RP | 2 |
| Wang, HY | 1 |
| Friedman, E | 1 |
| Huang, HM | 1 |
| Gibson, GE | 2 |
| Wolozin, B | 1 |
| Lesch, P | 1 |
| Lebovics, R | 1 |
| Sunderland, T | 1 |
| Cowburn, RF | 4 |
| Vestling, M | 2 |
| Fowler, CJ | 1 |
| Ravid, R | 1 |
| Winblad, B | 3 |
| O'Neill, C | 1 |
| Garlind, A | 1 |
| Johnston, JA | 1 |
| Algotsson, A | 1 |
| Adem, A | 1 |
| Racchi, M | 1 |
| Lannfelt, L | 1 |
| Cedazo-Mínguez, A | 1 |
| Hamker, U | 1 |
| Meske, V | 1 |
| Veh, RW | 1 |
| Hellweg, R | 1 |
| Jacobi, C | 1 |
| Albert, F | 1 |
| Ohm, TG | 3 |
| Liu, HC | 1 |
| Yang, JC | 1 |
| Chang, YF | 1 |
| Liu, TY | 1 |
| Chi, CW | 1 |
| Bohl, J | 2 |
| Lemmer, B | 2 |
| Gietzen, DW | 1 |
| Fregeau, D | 1 |
| Goodman, T | 1 |
| Weiler, PG | 1 |
| Graf, K | 1 |
| Magliozzi, J | 1 |
| Malow, BA | 1 |
| Baker, AC | 1 |
| Blass, JP | 1 |
| Hörnqvist, R | 1 |
| Henriksson, R | 1 |
| Bäck, O | 1 |
| Bucht, G | 1 |
29 other studies available for isoproterenol and Alzheimer Disease
| Article | Year |
|---|---|
Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups.
Topics: Adrenergic beta-Agonists; Alzheimer Disease; Animals; Behavior, Animal; Blotting, Western; Brain; Ca | 2015 |
Effect of mesenchymal stem cells and galantamine nanoparticles in rat model of Alzheimer's disease.
Topics: Adrenergic beta-Agonists; Alzheimer Disease; Animals; Behavior, Animal; Cells, Cultured; Combined Mo | 2016 |
A 5-year longitudinal study of the relationships between stress, coping, and immune cell beta(2)-adrenergic receptor sensitivity.
Topics: Adaptation, Psychological; Age Factors; Aged; Alzheimer Disease; Caregivers; Cyclic AMP; Emotions; F | 2008 |
Torsades de Pointes with QT prolongation related to donepezil use.
Topics: Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Colitis; Donepezil; Electrocardiogr | 2009 |
Melatonin attenuates isoproterenol-induced protein kinase A overactivation and tau hyperphosphorylation in rat brain.
Topics: Alzheimer Disease; Animals; Antioxidants; Brain; Cyclic AMP-Dependent Protein Kinases; Isoproterenol | 2004 |
Correlation of behavior changes and BOLD signal in Alzheimer-like rat model.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Hippocampus; Isoproterenol; Magnetic Resonance I | 2004 |
Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat.
Topics: Alzheimer Disease; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Prote | 2005 |
Prevention of isoproterenol-induced tau hyperphosphorylation by melatonin in the rat.
Topics: Alzheimer Disease; Animals; Brain; Isoproterenol; Male; Melatonin; Neurofibrillary Tangles; Phosphor | 2005 |
Correlation of Alzheimer-like tau hyperphosphorylation and fMRI bold intensity.
Topics: Alzheimer Disease; Animals; Cerebral Cortex; Cerebrovascular Circulation; Cyclic AMP-Dependent Prote | 2004 |
Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Benzylamines; Brain; C | 2007 |
Association of DSC1, a gene modulated by adrenergic stimulation, with Alzheimer's disease.
Topics: Adrenergic beta-Agonists; Aged; Aged, 80 and over; Alzheimer Disease; Cell Line, Tumor; Desmocollins | 2006 |
Stress-related reduction in personal mastery is associated with reduced immune cell beta2-adrenergic receptor sensitivity.
Topics: Adaptation, Psychological; Aged; Alzheimer Disease; Attitude of Health Personnel; Caregivers; Female | 2007 |
Regulation of phosphorylation of tau by protein kinases in rat brain.
Topics: Alzheimer Disease; Androstadienes; Animals; Blotting, Western; Bradykinin; Brain Chemistry; Calcium- | 2006 |
Alzheimer amyloid beta-peptide A-beta25-35 blocks adenylate cyclase-mediated forms of hippocampal long-term potentiation.
Topics: Adenylyl Cyclase Inhibitors; Adrenergic beta-Agonists; Alzheimer Disease; Amyloid beta-Peptides; Ani | 2007 |
Acute desensitization of lymphocyte beta-adrenergic-stimulated adenylate cyclase in old age and Alzheimer's disease.
Topics: Adenylyl Cyclases; Adult; Aged; Aging; Alzheimer Disease; Cyclic AMP; Female; Humans; In Vitro Techn | 1984 |
Alzheimer's disease: isoproterenol and prostaglandin E1-stimulated cyclic AMP accumulation in lymphocytes.
Topics: Adult; Age Factors; Aged; Alprostadil; Alzheimer Disease; Cyclic AMP; Female; Humans; Isoproterenol; | 1984 |
Receptor-mediated activation of G proteins is reduced in postmortem brains from Alzheimer's disease patients.
Topics: Aged; Alzheimer Disease; Biotransformation; Brain Chemistry; Carbachol; Female; GTP-Binding Proteins | 1994 |
Altered beta-adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors.
Topics: Adenylate Cyclase Toxin; Adrenergic beta-Agonists; Aged; Alzheimer Disease; Cells, Cultured; Cholera | 1993 |
A.E. Bennett Research Award 1993. Olfactory neuroblasts from Alzheimer donors: studies on APP processing and cell regulation.
Topics: Adenosine Monophosphate; Adolescent; Adult; Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; | 1993 |
Disrupted beta 1-adrenoceptor-G protein coupling in the temporal cortex of patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Binding, Competitive; Female; GTP-Binding Proteins; Guanylyl Imidodiphospha | 1993 |
Decreased beta-adrenoceptor-stimulated adenylyl cyclase activity in lymphocytes from Alzheimer's disease patients.
Topics: Adenylyl Cyclases; Aged; Alzheimer Disease; Colforsin; Dose-Response Relationship, Drug; Female; Hum | 1997 |
Differential regulation of adenylyl cyclase in fibroblasts from sporadic and familial Alzheimer's disease cases with PS1 and APP mutations.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyl | 1997 |
Regulation of apolipoprotein E secretion in rat primary hippocampal astrocyte cultures.
Topics: Alzheimer Disease; Animals; Animals, Newborn; Apolipoproteins E; Astrocytes; Bucladesine; Carbachol; | 2001 |
Analysis of monoamines in the cerebrospinal fluid of Chinese patients with Alzheimer's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alzheimer Disease; China; Chromatography, High Pressure Liquid; Dihy | 1991 |
Reduced basal and stimulated (isoprenaline, Gpp(NH)p, forskolin) adenylate cyclase activity in Alzheimer's disease correlated with histopathological changes.
Topics: Adenylyl Cyclases; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Colforsin; Female; Guanylyl Im | 1991 |
Lymphocyte beta-adrenoceptor/effector complex in aging and dementia of the Alzheimer type.
Topics: Adult; Aged; Aging; Alzheimer Disease; Cyclic AMP; Humans; Isoproterenol; Lymphocytes; Receptors, Ad | 1989 |
Cultured cells as a screen for novel treatments of Alzheimer's disease.
Topics: Alzheimer Disease; Carnitine; Cells, Cultured; Cyclic AMP; Fibroblasts; Humans; Hydrogen-Ion Concent | 1989 |
Reduced cAMP-signal transduction in postmortem hippocampus of demented old people.
Topics: Adenylyl Cyclases; Aged; Alzheimer Disease; Colforsin; Cyclic AMP; Enzyme Activation; Female; Guanyl | 1989 |
Iontophoretic study of adrenergic and cholinergic skin vessel reactivity in normal ageing and Alzheimer's disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Autonomic Agents; Humans; Iont | 1987 |