isoproterenol has been researched along with ANS (Autonomic Nervous System) Diseases in 31 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diseases characterized by neurogenic orthostatic hypotension (NOH), such as Parkinson disease (PD) and pure autonomic failure (PAF), are associated with cardiac sympathetic denervation, as reflected by low myocardial concentrations of 6-[(18)F]fluorodopamine-derived radioactivity." | 1.35 | Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension. ( Bentho, O; Eldadah, BA; Goldstein, DS; Grossman, E; Holmes, C; Imrich, R; Pechnik, S; Sharabi, Y, 2009) |
| "In 30 patients with AV nodal reentrant tachycardia, time- and frequency-domain measures of heart rate variability (HRV) were measured before, 30 minutes after, and 1 day after slow pathway ablation." | 1.32 | Time course and predictors of autonomic dysfunction after ablation of the slow atrioventricular nodal pathway. ( Christini, DJ; Iwai, S; Lerman, BB; Markowitz, SM; Mittal, S; Slotwiner, DJ; Stein, KM, 2004) |
| "Nine women with mitral valve prolapse and symptoms and signs of beta-adrenergic hypersensitivity and seven normal volunteer women were studied." | 1.27 | Mitral valve prolapse with symptoms of beta-adrenergic hypersensitivity. Beta 2-adrenergic receptor supercoupling with desensitization on isoproterenol exposure. ( Davies, AO; Mares, A; Pool, JL; Taylor, AA, 1987) |
| "Isoproterenol was only taken up by a non-neuronal uptake; this finding may indicate that neuronal uptake is not important for the inactivation of circulating catecholamines." | 1.27 | Noradrenaline and isoproterenol kinetics in diabetic patients with and without autonomic neuropathy. ( Christensen, NJ; Dejgaard, A; Hilsted, J, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (54.84) | 18.7374 |
| 1990's | 7 (22.58) | 18.2507 |
| 2000's | 4 (12.90) | 29.6817 |
| 2010's | 3 (9.68) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lingappa, JR | 1 |
| Zigmond, RE | 1 |
| Almeida, FR | 1 |
| Perry, JC | 1 |
| Futuro-Neto, HA | 1 |
| Almeida, VR | 1 |
| Sebastião, RM | 1 |
| Andersen, ML | 1 |
| Tufik, S | 1 |
| Campos, RR | 1 |
| Bergamaschi, CT | 1 |
| Baker, CN | 1 |
| Gidus, SA | 1 |
| Price, GF | 1 |
| Peoples, JN | 1 |
| Ebert, SN | 1 |
| Imrich, R | 1 |
| Eldadah, BA | 1 |
| Bentho, O | 1 |
| Pechnik, S | 1 |
| Sharabi, Y | 1 |
| Holmes, C | 1 |
| Grossman, E | 1 |
| Goldstein, DS | 1 |
| MITSUSE, J | 1 |
| FRICK, MH | 1 |
| HAERTEL, G | 1 |
| PUNSAR, S | 1 |
| Lavi, S | 1 |
| Aharon-Peretz, J | 1 |
| Haim, N | 1 |
| Vlodavsky, E | 1 |
| Jacob, G | 1 |
| Markowitz, SM | 1 |
| Christini, DJ | 1 |
| Stein, KM | 1 |
| Mittal, S | 1 |
| Iwai, S | 1 |
| Slotwiner, DJ | 1 |
| Lerman, BB | 1 |
| Man in't Veld, AJ | 1 |
| Boomsma, F | 1 |
| Schalekamp, MA | 1 |
| Bannister, R | 1 |
| Boylston, AW | 1 |
| Davies, IB | 1 |
| Mathias, CJ | 1 |
| Sever, PS | 1 |
| Sudera, D | 1 |
| Robertson, D | 1 |
| Hollister, AS | 1 |
| Carey, EL | 1 |
| Tung, CS | 1 |
| Goldberg, MR | 1 |
| Robertson, RM | 1 |
| Moreno Martínez, J | 1 |
| Gómez Marino, MA | 1 |
| Garrido Carríon, A | 1 |
| Navarro Ruiz, V | 1 |
| Uraoka, T | 1 |
| Sugimoto, T | 1 |
| Iuchi, K | 1 |
| Kaseno, K | 1 |
| Ohshiro, Y | 1 |
| Nohara, T | 1 |
| Boudoulas, H | 1 |
| Schaal, SF | 1 |
| Leier, CV | 1 |
| Lewis, RP | 1 |
| Williams, RS | 1 |
| Bashore, TM | 1 |
| Hirayama, M | 2 |
| Hakusui, S | 1 |
| Koike, Y | 2 |
| Ito, K | 1 |
| Kato, T | 1 |
| Ikeda, M | 1 |
| Hasegawa, Y | 1 |
| Takahashi, A | 1 |
| Biaggioni, I | 1 |
| Garcia, F | 1 |
| Inagami, T | 1 |
| Haile, V | 1 |
| Raj, SR | 1 |
| Brouillard, D | 1 |
| Simpson, CS | 1 |
| Hopman, WM | 1 |
| Abdollah, H | 1 |
| Perna, S | 1 |
| Leone, R | 1 |
| Farace, MJ | 1 |
| Brescia-Morra, V | 1 |
| Campanella, G | 1 |
| Brevetti, G | 1 |
| Baser, SM | 1 |
| Brown, RT | 1 |
| Curras, MT | 1 |
| Baucom, CE | 1 |
| Hooper, DR | 1 |
| Polinsky, RJ | 1 |
| Davies, AO | 3 |
| Su, CJ | 1 |
| Balasubramanyam, A | 1 |
| Codina, J | 1 |
| Birnbaumer, L | 1 |
| Hrushesky, WJ | 1 |
| Chida, K | 1 |
| Sakamaki, S | 1 |
| Takasu, T | 1 |
| Lehmann, KG | 1 |
| Shandling, AH | 1 |
| Yusi, AU | 1 |
| Froelicher, VF | 1 |
| Taylor, AA | 2 |
| Mares, A | 2 |
| Raschko, J | 1 |
| Pool, JL | 2 |
| Nelson, EB | 1 |
| Mitchell, JR | 1 |
| Dejgaard, A | 1 |
| Hilsted, J | 2 |
| Christensen, NJ | 2 |
| Nakashima, Y | 1 |
| Fouad, FM | 1 |
| Nakamoto, S | 1 |
| Textor, SC | 1 |
| Bravo, EL | 1 |
| Tarazi, RC | 1 |
| Eriksson, P | 1 |
| Boman, K | 1 |
| Jacobsson, B | 1 |
| Olofsson, BO | 1 |
| Dejgård, A | 1 |
| Kühl, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Identifying the Pathophysiology of Neurogenic Orthostatic Hypotension and the Effects of Melatonin on Reducing Supine Hypertension in Peripherally Intact Versus Denervated Post-ganglionic Sympathetic Nerves[NCT02963181] | Early Phase 1 | 10 participants (Actual) | Interventional | 2018-03-01 | Terminated (stopped due to PI leaving) | ||
| Effect of Nebivolol on Blood Pressure in a Model of Hypertension Sensitive to Potentiation of Nitric Oxide Bioactivity[NCT01044693] | 20 participants (Actual) | Interventional | 2010-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change from baseline (8 pm) in heart rate at the time of maximal BP-lowering effect (NCT01044693)
Timeframe: 8 pm - 8 am
| Intervention | bpm (Mean) |
|---|---|
| Placebo Capsule | -3 |
| Nebivolol 5 mg | -6 |
| Metoprolol Tartrate 50 mg | -6 |
| Sildenafil 25 mg | 0 |
Nocturnal sodium excretion was defined as the ratio of urinary sodium to urinary creatinine. (NCT01044693)
Timeframe: 8 pm - 8 am
| Intervention | mEq/mg (Mean) |
|---|---|
| Placebo Capsule | 0.145 |
| Nebivolol 5 mg | 0.127 |
| Metoprolol Tartrate 50 mg | 0.139 |
| Sildenafil 25 mg | 0.125 |
Orthostatic tolerance was defined as the area under the curve of standing systolic blood pressure calculated by the trapezoidal rule (upright systolic blood pressure multiplied by standing time) during a 10-minute standing test (NCT01044693)
Timeframe: 10 min standing
| Intervention | mm Hg*min (Mean) |
|---|---|
| Placebo Capsule | 594 |
| Nebivolol 5 mg | 675 |
| Metoprolol Tartrate 50 mg | 696 |
| Sildenafil 25 mg | 575 |
Maximal change from baseline in systolic blood pressure, measured from 8 pm to 8 am, after a single dose of the intervention (NCT01044693)
Timeframe: 8 pm - 8 am
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Baseline supine at 8 pm | Change in systolic BP | |
| Metoprolol Tartrate 50 mg | 157 | -7 |
| Nebivolol 5 mg | 162 | -24 |
| Placebo Capsule | 154 | 1 |
| Sildenafil 25 mg | 158 | -20 |
1 review available for isoproterenol and ANS (Autonomic Nervous System) Diseases
| Article | Year |
|---|---|
[Pharmacological test].
Topics: Arginine Vasopressin; Autonomic Nervous System; Autonomic Nervous System Diseases; Blood Pressure; H | 1997 |
30 other studies available for isoproterenol and ANS (Autonomic Nervous System) Diseases
| Article | Year |
|---|---|
Limited recovery of pineal function after regeneration of preganglionic sympathetic axons: evidence for loss of ganglionic synaptic specificity.
Topics: Animals; Arylalkylamine N-Acetyltransferase; Autonomic Nervous System Diseases; Axons; Biophysics; B | 2013 |
Cardiovascular function alterations induced by acute paradoxical sleep deprivation in rats.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System Diseases; Baroreflex; Blood Pressure; Heart | 2014 |
Impaired cardiac energy metabolism in embryos lacking adrenergic stimulation.
Topics: Adrenergic Agents; Animals; Autonomic Nervous System Diseases; Dopamine beta-Hydroxylase; Embryo, Ma | 2015 |
Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension.
Topics: Adrenergic beta-Agonists; Aged; Autonomic Nervous System Diseases; Blood Pressure; Dopamine; Female; | 2009 |
[RECURRENCE OF BRONCHIAL ASTHMA, FACTORS CAUSING EXACERBATION AND THERAPY].
Topics: Aminophylline; Anti-Allergic Agents; Asthma; Autonomic Nervous System Diseases; Ephedrine; Epinephri | 1963 |
ABNORMAL CIRCULATORY RESPONSES TO EXERCISE AS SEQUELAE TO ENCEPHALITIS.
Topics: Autonomic Nervous System Diseases; Cardiac Catheterization; Encephalitis; Exercise; Heart Rate; Hemo | 1964 |
Unusual cause of partially reversible severe cardiovascular autonomic failure.
Topics: Autonomic Nervous System; Autonomic Nervous System Diseases; Cardiovascular Diseases; Cardiovascular | 2003 |
Time course and predictors of autonomic dysfunction after ablation of the slow atrioventricular nodal pathway.
Topics: Adult; Autonomic Nervous System Diseases; Cardiotonic Agents; Catheter Ablation; Female; Follow-Up S | 2004 |
Effects of beta-adrenoceptor agonists and antagonists in patients with peripheral autonomic neuropathy.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Albuterol; Amyloidosis; Autonomi | 1982 |
beta-Receptor numbers and thermodynamics in denervation supersensitivity.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Dihydroalprenolol; Dose-Response Relationship, Drug; | 1981 |
Increased vascular beta2-adrenoceptor responsiveness in autonomic dysfunction.
Topics: Aged; Autonomic Nervous System Diseases; Blood Pressure; Blood Vessels; Epinephrine; Female; Heart R | 1984 |
[Shy-Drager syndrome: clinical and hemodynamic study].
Topics: Acetylcholine; Aged; Angiotensin II; Autonomic Nervous System Diseases; Catheterization; Hemodynamic | 1983 |
[Case of autonomic dystonia with "ischemic" ST-T abnormalities].
Topics: Adult; Autonomic Nervous System Diseases; Electrocardiography; Exercise Test; Humans; Isoproterenol; | 1983 |
The role of the autonomic nervous system in patients with sinoatrial and atrioventricular node dysfunction.
Topics: Adult; Aged; Atrioventricular Node; Atropine; Autonomic Nervous System Diseases; Bundle of His; Drug | 1981 |
Paroxysmal hypotension associated with sympathetic withdrawal. A new disorder of autonomic vasomotor regulation.
Topics: Atropine; Autonomic Nervous System Diseases; Blood Pressure; Cardiac Pacing, Artificial; Catecholami | 1980 |
A scintigraphical qualitative analysis of peripheral vascular sympathetic function with meta-[123I]iodobenzylguanidine in neurological patients with autonomic failure.
Topics: 3-Iodobenzylguanidine; Aged; Autonomic Nervous System Diseases; Female; Humans; Iodine Radioisotopes | 1995 |
Hyporeninemic normoaldosteronism in severe autonomic failure.
Topics: Aged; Aldosterone; Autonomic Nervous System Diseases; Dopamine beta-Hydroxylase; Female; Humans; Imm | 1993 |
Dysautonomia among patients with fibromyalgia: a noninvasive assessment.
Topics: Adult; Autonomic Nervous System Diseases; Electrocardiography, Ambulatory; Female; Fibromyalgia; Hea | 2000 |
Beta-adrenoceptor modulation in a case of pure autonomic failure.
Topics: Autonomic Nervous System Diseases; Blood Pressure; Catecholamines; Chromatography, High Pressure Liq | 1992 |
Beta-receptor sensitivity in autonomic failure.
Topics: Autonomic Nervous System Diseases; Cardiovascular System; Female; Humans; Isoproterenol; Male; Middl | 1991 |
Abnormal guanine nucleotide regulatory protein in MVP dysautonomia: evidence from reconstitution of Gs.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Adult; Animals; Autonomic Nervous System Diseases; | 1991 |
Quantitative respiratory sinus arrhythmia analysis. A simple noninvasive, reimbursable measure of cardiac wellness and dysfunction.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Atropine; Autonomic Nervous System Diseases | 1991 |
Alteration in autonomic function and cardiovascular regulation in amyotrophic lateral sclerosis.
Topics: Aged; Amyotrophic Lateral Sclerosis; Atropine; Autonomic Nervous System; Autonomic Nervous System Di | 1989 |
Altered ventricular repolarization in central sympathetic dysfunction associated with spinal cord injury.
Topics: Autonomic Nervous System Diseases; Cold Temperature; Electrocardiography; Exercise Test; Heart; Hear | 1989 |
Spectrum of dysautonomia in mitral valvular prolapse.
Topics: Adolescent; Adult; Autonomic Nervous System Diseases; Epinephrine; Female; Hemodynamics; Humans; Imm | 1989 |
Mitral valve prolapse with symptoms of beta-adrenergic hypersensitivity. Beta 2-adrenergic receptor supercoupling with desensitization on isoproterenol exposure.
Topics: Adult; Autonomic Nervous System Diseases; Blood Pressure; Epinephrine; Female; Heart Rate; Humans; I | 1987 |
Noradrenaline and isoproterenol kinetics in diabetic patients with and without autonomic neuropathy.
Topics: Adult; Autonomic Nervous System Diseases; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Neuropa | 1986 |
Localization of autonomic nervous system dysfunction in dialysis patients.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Blood Pressure; Female; Heart Rate; Humans; Isoprote | 1987 |
Cardiac arrhythmias in familial amyloid polyneuropathy during anaesthesia.
Topics: Adult; Aged; Amyloidosis; Anesthesia; Arrhythmias, Cardiac; Autonomic Nervous System Diseases; Brady | 1986 |
Noradrenaline kinetics in diabetic autonomic neuropathy.
Topics: Autonomic Nervous System Diseases; Diabetic Neuropathies; Humans; Isoproterenol; Kinetics; Metabolic | 1985 |