isoprodian and Leprosy

isoprodian has been researched along with Leprosy* in 10 studies

Trials

1 trial(s) available for isoprodian and Leprosy

ArticleYear
Comparison of DDS with two combined chemotherapy regimens for multibacillary leprosy. Results after 3 years of treatment. A prospective randomized multicentre study.
    Leprosy review, 1986, Volume: 57 Suppl 3

    Topics: Adult; Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Isoniazid; Isonicotinic Acids; Leprostatic Agents; Leprosy; Male; Prospective Studies; Prothionamide; Random Allocation; Rifampin

1986

Other Studies

9 other study(ies) available for isoprodian and Leprosy

ArticleYear
Can leprosy be eradicated with chemotherapy? An evaluation of the Malta Leprosy Eradication Project.
    Leprosy review, 2008, Volume: 79, Issue:4

    The Malta Leprosy Eradication Project (MLEP) was proposed in 1971 by Freerksen with the aim of eradicating leprosy in Malta. The project involved re-treatment of all known cases in Malta as of 1972 and all new cases thereafter with a regimen consisting of Isoprodian (a combination of dapsone, prothionamide and isoniazid) and rifampicin for varying intervals depending on the severity of their disease and their response to treatment. Overall the response to therapy was excellent with an extremely low relapse rate. During the 30 years of the project the incidence of leprosy steadily decreased continuing a decline that had started at least two decades earlier and Freerksen declared the disease eradicated from Malta in 2001. Although given the long incubation period of leprosy cases may still be occasionally detected in the future, the disease has been basically eradicated at this time and there are no patients currently receiving treatment. This work was done at the leprosy clinic, Boffa Hospital, Floriana, Malta.

    Topics: Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Isoniazid; Leprostatic Agents; Leprosy; Male; Malta; Program Evaluation; Prothionamide; Rifampin; Treatment Outcome

2008
Side-effects of Isoprodian compared with WHO-MDT in rural Nepal.
    Leprosy review, 1993, Volume: 64, Issue:3

    Topics: Adolescent; Adult; Aged; Child; Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Isoniazid; Leprostatic Agents; Leprosy; Male; Middle Aged; Prothionamide; Rural Health

1993
Isoprodian and rifampicin in the treatment of leprosy: a descriptive evaluation of therapy durations in 475 Paraguayan leprosy patients.
    Chemotherapy, 1989, Volume: 35, Issue:5

    In Paraguay, the National Leprosy/Tuberculosis Program is based on a combined chemotherapy with isoprodian and rifampicin. The aim of this descriptive study was to investigate the therapy durations used so far in the treatment of 475 leprosy patients and to analyze the criteria responsible for the wide-ranging differences in therapy durations. As initial criteria, the following parameters were identified to have a significant influence on the therapy duration: Patients never treated before or pretreated, clinical classification and initial bacteriological index (BI) value. During therapy, conditions like the attendance and BI decrease/year showed a significant correlation with the therapy duration. Even though the studied criteria did not allow to draw a definite conclusion with regard to an 'ideal' therapy duration, they proved to be reliable, as only 2 patients have relapsed so far.

    Topics: Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Isoniazid; Isonicotinic Acids; Leprostatic Agents; Leprosy; Leprosy, Borderline; Leprosy, Lepromatous; Leprosy, Tuberculoid; Mycobacterium leprae; Paraguay; Patient Compliance; Prothionamide; Rifampin; Time Factors

1989
The Malta experience. Isoprodian-rifampicin combination treatment for leprosy.
    Leprosy review, 1986, Volume: 57 Suppl 3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Isoniazid; Isonicotinic Acids; Leprostatic Agents; Leprosy; Male; Middle Aged; Prothionamide; Rifampin

1986
First assessment of the Malta Leprosy Eradication Project.
    Leprosy review, 1986, Volume: 57 Suppl 3

    Topics: Dapsone; Drug Combinations; Drug Therapy, Combination; Evaluation Studies as Topic; Follow-Up Studies; Humans; Isoniazid; Isonicotinic Acids; Leprostatic Agents; Leprosy; Malta; Prothionamide; Recurrence; Rifampin

1986
Report of the joint leprosy-tuberculosis project in Paraguay.
    Leprosy review, 1986, Volume: 57 Suppl 3

    Topics: Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Isoniazid; Leprostatic Agents; Leprosy; Paraguay; Prothionamide; Rifampin; Tuberculosis

1986
The impact of MDT implementation in the Tanzania National TB-Leprosy Programme.
    Leprosy review, 1986, Volume: 57 Suppl 3

    Topics: Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Isoniazid; Isonicotinic Acids; Leprostatic Agents; Leprosy; Male; Prothionamide; Rifampin; Tanzania

1986
Recent trends in chemotherapy of leprosy.
    The Journal of the Association of Physicians of India, 1985, Volume: 33, Issue:9

    Topics: Clofazimine; Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Isoniazid; Leprostatic Agents; Leprosy; Mycobacterium leprae; Prothionamide; Rifampin

1985
Combined therapy in leprosy. Background and findings.
    Chemotherapy, 1978, Volume: 24, Issue:3

    This report is based on data obtained from 64 lepromatous cases. Despite many years of DDS monotherapy, the homogenates from biopsies of these patients revealed 10(4) or more bacteria. From the beginning of combination therapy with synergistic-acting substances (rifampicin + isoprodian (INH + PTH + DDS) the logarithms of the number of bacteria in the homogenates decreased, both during treatment period and during treatment-free observation period (Figs. 3--8). During the whole time biopsies were taken almost monthly. A considerable regression of the bacterial mass or even "negativity" could be observed within a relatively short time. Once started, the process of reduction of bacteria continued also after termination of therapy. To be able to evaluate a medication, therapy-free observation periods (for a minimum of 5 years) are indispensable.

    Topics: Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Isoniazid; Leprostatic Agents; Leprosy; Prothionamide; Rifampin

1978
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