isopimaric-acid has been researched along with Atrial-Fibrillation* in 2 studies
2 other study(ies) available for isopimaric-acid and Atrial-Fibrillation
| Article | Year |
|---|---|
Isopimaric acid - a multi-targeting ion channel modulator reducing excitability and arrhythmicity in a spontaneously beating mouse atrial cell line.
Atrial fibrillation is the most common persistent cardiac arrhythmia, and it is not well controlled by present drugs. Because some resin acids open voltage-gated potassium channels and reduce neuronal excitability, we explored the effects of the resin acid isopimaric acid (IPA) on action potentials and ion currents in cardiomyocytes.. Spontaneously beating mouse atrial HL-1 cells were investigated with the whole-cell patch-clamp technique.. 1-25 μmol L. Low concentrations of IPA reduced the action potential frequency and restored regular firing by altering the voltage dependencies of several voltage-gated ion channels. These findings can form the basis for a new pharmacological strategy to treat atrial fibrillation. Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Carboxylic Acids; Cell Line; Heart Atria; Ion Channel Gating; Ion Channels; Mice; Phenanthrenes | 2018 |
Can principles of the surface potential be combined with knowledge of natural products to reduce atrial rhythm disturbances?
Topics: Animals; Atrial Fibrillation; Biological Products; Carboxylic Acids; Cell Line; Heart Atria; Ion Channels; Mice; Phenanthrenes | 2018 |