isoniazid and Thrombopenia studies

Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).

Research Excerpts

Excerpt	Relevance	Reference
"Isoniazid monotherapy was restarted after 2 weeks."	5.38	A case of isoniazid-induced thrombocytopenia: recovery with immunoglobulin therapy. ( Cho, YJ; Hwang, YS; Jeong, YY; Kim, HC; Kim, YE; Lee, EJ; Lee, JD; Lee, SH; Lee, SJ, 2012)
"We report the case of a 13-year-old girl with tuberculosis who developed persistent symptomatic thrombocytopenia whilst being treated with rifampicin and isoniazid."	3.75	Carry on doctor. ( Carroll, WD; Nair, S, 2009)
"Rifampin is a potent antituberculous drug."	2.35	Rifampin. ( Dorken, E; Grzybowski, S; Schonell, M, 1972)
"Isoniazid monotherapy was restarted after 2 weeks."	1.38	A case of isoniazid-induced thrombocytopenia: recovery with immunoglobulin therapy. ( Cho, YJ; Hwang, YS; Jeong, YY; Kim, HC; Kim, YE; Lee, EJ; Lee, JD; Lee, SH; Lee, SJ, 2012)
" This association of toxic reactions with antibodies is highly significant (P<0."	1.25	Potentially serious side effects of high-dose twice-weekly rifampicin. ( Poole, G; Stradling, P; Worlledge, S, 1971)

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (67.74)	18.7374
1990's	4 (12.90)	18.2507
2000's	1 (3.23)	29.6817
2010's	3 (9.68)	24.3611
2020's	2 (6.45)	2.80

Authors	Studies
Vargas, JC	1
Bezerra, PN	1
Sequeira, M	1
Oliveira, GH	1
Pegolo, CE	1
Fiore, L	1
Hamerschlak, N	1
Ferreira, PRA	1
Kuwabara, G	1
Tazoe, K	1
Imoto, W	1
Yamairi, K	1
Shibata, W	1
Oshima, K	1
Yamada, K	1
Takagi, Y	1
Shiraishi, S	1
Hino, M	1
Kawaguchi, T	1
Kakeya, H	1
Song, J	1
Liu, T	1
Zhao, Z	1
Hu, X	1
Wu, Q	1
Peng, W	1
Chen, X	1
Ying, B	1
Nair, S	1
Carroll, WD	1
Lee, EJ	1
Lee, SH	1
Kim, YE	1
Lee, SJ	1
Cho, YJ	1
Jeong, YY	1
Kim, HC	1
Lee, JD	1
Hwang, YS	1
Önem, Y	1
BAART DE LA FAILLE, RL	1
VERLOOP, MC	1
CARDINALI, G	1
MAJ, A	1
MUELLER, HC	1
HANSEN, JE	1
Wong, PC	1
Yew, WW	1
Wong, CF	1
Choi, HY	1
Kindelán, JM	1
Serrano, I	1
Jurado, R	1
Villanueva, JL	1
García-Lázaro, M	1
García-Herola, A	1
Torre Cisneros, J	1
Beji, M	1
Louzir, B	1
Ben Rhomdane, N	1
Zouari, M	1
Mtimet, B	1
Daghfous, J	1
Dutt, AK	1
Jones, L	1
Stead, WW	1
Addington, WW	1
Gravanis, MB	1
Majmudar, BN	1
Schlegel, H	1
Sadoun, D	1
Le Roux, G	1
Guillevin, L	1
Battesti, JP	1
Mühlberger, F	1
Chioléro, R	1
Cornet, A	1
Cornu, P	1
Dubrisay, J	1
Barbier, JP	1
Hirsch, JF	1
Carnot, F	1
Miele, JF	1
Rothstein, SS	1
Williams, AC	1
Feigin, RD	1
Zarkowsky, HF	1
Shearer, W	1
Anderson, DC	1
Schonell, M	1
Dorken, E	1
Grzybowski, S	1
Dickerman, JD	1
Holbrook, PR	1
Zinkham, WH	1
Favez, G	1
Wiser, H	1
Dormont, J	1
Schwarzenberg, L	1
Proust, AJ	1
Poole, G	2
Stradling, P	2
Worlledge, S	2
MacCurdy, RK	1
Simon, ER	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Rifampin to Reduce Elevated Levels of Blood and Urine Calcium in Patients With Idiopathic Infantile Hypercalcemia[NCT03384121]			Phase 1	5 participants (Anticipated)	Interventional	2018-02-22	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Controlled trial of intermittent regimens of rifampin plus isoniazid for pulmonary tuberculosis in Singapore. The results up to 30 months. The American review of respiratory disease, 1977, Volume: 116, Issue:5 Topics: Adolescent; Adult; Antibodies; Clinical Trials as Topic; Drug Resistance, Microbial; Drug Therapy, C	1977
[Rifampicin in the treatment of active pulmonary tuberculosis. Controlled trial of isoniazid-rifampicin-thiocarlide versus isoniazid-streptomycin-thiocarlide in untreated tuberculosis. Treatment of relapses with the combination rifampicin-ethambutol-thioc Schweizerische medizinische Wochenschrift, 1974, Mar-09, Volume: 104, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drug Hypersensitivity; Drug Therap	1974
The Australian rifampicin trial. The Medical journal of Australia, 1971, Jul-10, Volume: 2, Issue:2 Topics: Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Clinical Trials as Topic; Eosinophilia	1971

Article	Year
Immune thrombocytopenia associated with lymph node tuberculosis: a case report. Revista da Sociedade Brasileira de Medicina Tropical, 2023, Volume: 56 Topics: Adult; Antitubercular Agents; Humans; Isoniazid; Male; Platelet Count; Purpura, Thrombocytopenic, Id	2023
Isoniazid-induced Immune Thrombocytopenia. Internal medicine (Tokyo, Japan), 2021, Nov-15, Volume: 60, Issue:22 Topics: Aged; Humans; Isoniazid; Male; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Rifampin; Thro	2021
Genetic polymorphisms of long noncoding RNA RP11-37B2.1 associate with susceptibility of tuberculosis and adverse events of antituberculosis drugs in west China. Journal of clinical laboratory analysis, 2019, Volume: 33, Issue:5 Topics: Adult; Anemia; Antitubercular Agents; Asian People; Case-Control Studies; China; Female; Genetic Pre	2019
Carry on doctor. Archives of disease in childhood, 2009, Volume: 94, Issue:9 Topics: Adolescent; Antibiotics, Antitubercular; Female; Humans; Isoniazid; Lung; Radiography; Rifampin; Thr	2009
A case of isoniazid-induced thrombocytopenia: recovery with immunoglobulin therapy. Internal medicine (Tokyo, Japan), 2012, Volume: 51, Issue:7 Topics: Antitubercular Agents; Humans; Immunization, Passive; Immunoglobulins, Intravenous; Isoniazid; Male;	2012
Comments on: "a case of isoniazid-induced thrombocytopenia: recovery with immunoglobulin therapy". Internal medicine (Tokyo, Japan), 2012, Volume: 51, Issue:24 Topics: Antitubercular Agents; Humans; Immunoglobulins, Intravenous; Isoniazid; Male; Thrombocytopenia	2012
[A case of thrombopenic during administration of isonicotinic acid hydrazide (nidaton)]. Nederlands tijdschrift voor geneeskunde, 1953, Feb-28, Volume: 97, Issue:9 Topics: Isoniazid; Niacin; Nicotinic Acids; Purpura; Purpura, Thrombocytopenic; Thrombocytopenia	1953
[Hemorrhagic thrombopenia caused by isoniazid]. Minerva medica, 1955, Sep-05, Volume: 46, Issue:71 Topics: Humans; Isoniazid; Niacin; Nicotinic Acids; Purpura; Purpura, Thrombocytopenic; Thrombocytopenia; Tu	1955
[Werlhof's disease in isonicotinic acid hydrazide therapy]. Zeitschrift fur Tuberkulose, 1955, Volume: 106, Issue:4-5 Topics: Isomerism; Isoniazid; Niacin; Nicotinic Acids; Purpura; Purpura, Thrombocytopenic; Purpura, Thromboc	1955
Hypersensitivity to isoniazid with neutropenia and thrombocytopenia. The American review of respiratory disease, 1961, Volume: 83 Topics: Agranulocytosis; Humans; Isoniazid; Leukopenia; Neutropenia; Thrombocytopenia	1961
Ethambutol-induced pulmonary infiltrates with eosinophilia and skin involvement. The European respiratory journal, 1995, Volume: 8, Issue:5 Topics: Aged; Drug Eruptions; Drug Therapy, Combination; Eosinophilia; Ethambutol; Female; Humans; Isoniazid	1995
Rifampin-induced severe thrombocytopenia in a patient with pulmonary tuberculosis. The Annals of pharmacotherapy, 1994, Volume: 28, Issue:11 Topics: Adult; Drug Administration Schedule; Ethambutol; Humans; Isoniazid; Male; Rifampin; Thrombocytopenia	1994
[Thrombocytopenia following a re-introduction of rifampicin in a daily treatment. Apropos of a case]. La Tunisie medicale, 1995, Volume: 73, Issue:5 Topics: Adult; Antibiotics, Antitubercular; Antitubercular Agents; Chemical and Drug Induced Liver Injury; D	1995
Short-course chemotherapy of tuberculosis with largely twice-weekly isoniazid-rifampin. Chest, 1979, Volume: 75, Issue:4 Topics: Adolescent; Adult; Aged; Drug Hypersensitivity; Humans; Isoniazid; Jaundice; Middle Aged; Rifampin;	1979
The side effects and interactions of antituberculosis drugs. Chest, 1979, Volume: 76, Issue:6 Suppl Topics: Adult; Aminosalicylic Acid; Antitubercular Agents; Central Nervous System Diseases; Chemical and Dru	1979
Clinicopathologic conference: a case of multiple myeloma followed up for 15 years. Southern medical journal, 1976, Volume: 69, Issue:2 Topics: Ascites; Cyclophosphamide; Diagnosis, Differential; Edema; Fluoxymesterone; Follow-Up Studies; Heman	1976
[Thrombopenia induced by isoniazid]. Annales de medecine interne, 1991, Volume: 142, Issue:8 Topics: Humans; Isoniazid; Male; Middle Aged; Thrombocytopenia	1991
[Allergy to antitubercular agents; with special reference to new drugs]. Schweizerische medizinische Wochenschrift, 1973, Jan-27, Volume: 103, Issue:4 Topics: Adult; Aged; Agranulocytosis; Anaphylaxis; Antitubercular Agents; Capreomycin; Cycloserine; Drug Hyp	1973
[Hematopoietic tuberculosis]. Annales de medecine interne, 1974, Volume: 125, Issue:4 Topics: Bone Marrow; Bone Marrow Examination; Cholestasis; Erythema; Ethambutol; Humans; Isoniazid; Leukopen	1974
Thrombocytopenia. Secondary to antituberculous therapy. Journal of the New Jersey Dental Association, 1974,Spring, Volume: 45, Issue:3 Topics: Dentistry; Isoniazid; Oral Manifestations; Thrombocytopenia	1974
Thrombocytopenia following administration of para-aminosalicylic acid. The Journal of pediatrics, 1973, Volume: 83, Issue:3 Topics: Aminosalicylic Acids; Humans; Infant; Isoniazid; Male; Streptomycin; Thrombocytopenia; Tuberculosis,	1973
Etiology and therapy of thrombocytopenia associated with sarcoidosis. The Journal of pediatrics, 1972, Volume: 81, Issue:4 Topics: Adolescent; Adult; Blood Platelets; Child; Child, Preschool; Female; Hematocrit; Humans; Isoniazid;	1972
[Side effects of tuberculostatics (author's transl)]. Munchener medizinische Wochenschrift (1950), 1973, Sep-28, Volume: 115, Issue:39 Topics: Adult; Antitubercular Agents; Drug Hypersensitivity; Ear; Ethambutol; Female; Humans; Isoniazid; Liv	1973
[Immunosuppressive treatment for heterologous cardiac transplantation. Its possible efficacy in a rejection crisis]. Archives des maladies du coeur et des vaisseaux, 1969, Volume: 62, Issue:6 Topics: Animals; Azathioprine; Betamethasone; Dexamethasone; Glucocorticoids; Graft Rejection; Heart Transpl	1969
Potentially serious side-effects of high-dose twice-weekly rifampicin. Postgraduate medical journal, 1971, Volume: 47, Issue:553 Topics: Acute Kidney Injury; Adolescent; Adult; Antibodies; Child; Complement Fixation Tests; Epistaxis; Fem	1971
Potentially serious side effects of high-dose twice-weekly rifampicin. British medical journal, 1971, Aug-07, Volume: 3, Issue:5770 Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Antibodies; Child; Coombs Test; Epistaxis; Female; Fev	1971
Thrombocytopenia and sideroblastic anemia with pyrazinoic acid amide (pyrazinamide) therapy. Chest, 1970, Volume: 57, Issue:4 Topics: Adolescent; Adult; Aged; Aminosalicylic Acids; Anemia, Sideroblastic; Antitubercular Agents; Cyclose	1970

isoniazid and Thrombopenia

Research Excerpts

Research

Studies (31)

Authors

Clinical Trials (1)

Trial Overview

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Trials

Other Studies