isoniazid has been researched along with Seizures in 239 studies
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of the study is to evaluate the effect of simultaneously administered isoniazid (300 mg/day) and phenytoin (300 mg/day) on 60 patients with tuberculous meningitis or tuberculoma having seizures." | 9.17 | Phenotypic interaction of simultaneously administered isoniazid and phenytoin in patients with tuberculous meningitis or tuberculoma having seizures. ( Adole, PS; Kharbanda, PS; Sharma, S; Singh, A, 2013) |
| "Pyridoxine hydrochloride, the antidote for isonicotinic acid hydrazide (INH)--induced seizures, is available in solution at a concentration of 100 mg/mL at a pH of less than 3." | 9.09 | Intravenous pyridoxine-induced metabolic acidosis. ( Curry, SC; Graeme, KA; Lovecchio, F; Suchard, J; Wallace, KL, 2001) |
| "Simultaneous administration of phenytoin and isoniazid (INH) in tuberculous meningitis (TBM) or tuberculoma patients with seizures results in higher plasma phenytoin level and thus phenytoin intoxication." | 7.83 | N-acetyltransferase 2 (NAT2) gene polymorphism as a predisposing factor for phenytoin intoxication in tuberculous meningitis or tuberculoma patients having seizures - A pilot study. ( Adole, PS; Kharbanda, PS; Sharma, S, 2016) |
| " Here, we investigated pharmacologically the functional significance of taurine-induced increase in GAD expression by determining the threshold for kainic acid-induced seizures after partial inhibition of GAD activity with isoniazide." | 7.74 | Selective resistance of taurine-fed mice to isoniazide-potentiated seizures: in vivo functional test for the activity of glutamic acid decarboxylase. ( El Idrissi, A; L'Amoreaux, WJ, 2008) |
| "Both isoniazid (INH) and cefazolin (CEZ) can have serious adverse effects on the central nervous system (CNS), causing seizures." | 7.73 | Effect of isoniazid on the pharmacodynamics of cefazolin-induced seizures in rats. ( Ishiwata, Y; Nagata, M; Yasuhara, M, 2005) |
| " Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma." | 7.73 | Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. ( Ekici, NZ; Kefi, A; Sakarya, M; Topcu, I; Yentur, EA, 2005) |
| "Rhabdomyolysis is one of the reported complications of isoniazid poisoning, but relevant data are limited." | 7.71 | Rhabdomyolysis in isoniazid poisoning. ( Corte-Maramba, NP; Makalinao, IR; Panganiban, LR, 2001) |
| "Isoniazid-induced seizures resulted in rhabdomyolysis and associated acute renal tubular necrosis in a dog." | 7.71 | Isoniazid-induced seizures with secondary rhabdomyolysis and associated acute renal failure in a dog. ( Haburjak, JJ; Spangler, WL, 2002) |
| "Isoniazid-induced seizures respond poorly to anticonvulsants but well to pyridoxine (Vitamin B6); theophylline produces difficult-to-treat seizures with substantial morbidity and mortality." | 7.70 | Seizures induced by theophylline and isoniazid in mice. ( Bonner, AB; Peterson, SL; Weir, MR, 1999) |
| "To report a case of reversible seizures and mental status changes in a dialysis patient given preventive isoniazid therapy." | 7.68 | Reversible seizures and mental status changes in a dialysis patient on isoniazid preventive therapy. ( Asnis, DS; Bhat, JG; Melchert, AF, 1993) |
| "The anticonvulsant effects of felbamate alone or in combination with diazepam were investigated against maximal electroshock-, pentylenetetrazol-, isoniazid- and bicuculline-induced seizures in mice." | 7.68 | Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1991) |
| "In an experimental condition of hyperthyroidism, obtained by repeated administration of triiodothyronine in adult rats (100 micrograms/kg/day, sc for 7 consecutive days), there is an increased susceptibility to the convulsant effect of isoniazid (300 mg/kg, ip) and picrotoxin (4 mg/kg, ip)." | 7.68 | Repeated administration of triiodothyronine enhances the susceptibility of rats to isoniazid- and picrotoxin-induced seizures. ( Bertolini, A; Marrama, D; Sandrini, M; Vergoni, AV, 1992) |
| "Pilocarpine, given intraperitoneally to rats, reproduces the neuropathological sequelae of temporal lobe epilepsy and provides a relevant animal model for studying mechanisms of buildup of convulsive activity and pathways operative in the generalization and propagation of seizures within the forebrain." | 7.67 | Susceptibility to seizures produced by pilocarpine in rats after microinjection of isoniazid or gamma-vinyl-GABA into the substantia nigra. ( Bortolotto, ZA; Cavalheiro, EA; De Moraes Mello, LE; Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Turski, WA, 1986) |
| "Amino acid concentrations were measured in the cortex, cerebellum and hippocampus of the mouse brain before and during seizures induced by isoniazid (250 mg/kg i." | 7.67 | The specific protective effect of diazepam and valproate against isoniazid-induced seizures is not correlated with increased GABA levels. ( Baltzer, V; Bernasconi, R; Jones, RS; Klein, M; Maître, L; Martin, P; Portet, C; Schmutz, M, 1985) |
| ") protected against seizures induced by maximal electroshock and increased the incidence and severity of seizures induced by bicuculline, in rats." | 7.66 | Morphine potentiates seizures induced by GABA antagonists and attenuates seizures induced by electroshock in the rat. ( Foote, F; Gale, K, 1983) |
| "Caerulein, cholecystokinin octapeptide (CCK-8) and diazepam delayed the onset of seizures produced by harman and thiosemicarbazide (TSC)." | 7.66 | Anticonvulsant effects of caerulein, cholecystokinin octapeptide (CCK-8) and diazepam against seizures produced in mice by harman, thiosemicarbazide and isoniazid. ( Zetler, G, 1981) |
| "Most reported cases of isoniazid-induced convulsive seizures occurred as a result of an overdose due to attempted suicide." | 5.40 | Convulsive seizures with a therapeutic dose of isoniazid. ( Fujisawa, N; Harada, E; Hashisako, M; Ikematsu, Y; Miyagi, H; Tsubouchi, K, 2014) |
| "Isoniazid (INH) is an integral component of treatment of tuberculosis." | 5.38 | Seizures with single therapeutic dose of isoniazid. ( Behera, D; Kumar, L; Puri, MM; Vishwakarma, PD, 2012) |
| "She presented repetitive generalized convulsions with metabolic acidosis, treated with diazepam and 7." | 5.31 | [Acute isoniazid poisoning presenting convulsion and liver dysfunction]. ( Hamabe, Y; Kiyota, K, 2001) |
| "She was in respiratory failure, with seizures that could not be stopped with diazepam." | 5.29 | [Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose]. ( Adler, M; Girsh-Solomonovich, Z; Raikhlin-Eisenkraft, B, 1993) |
| "Isoniazid is a useful chemical convulsant in that metabolic events associated with the preseizure state can be easily examined." | 5.26 | Isoniazid induced seizures and cerebral cortical and cerebellar energy metabolism. ( Abel, MS; McCandless, DW; Schwartzenburg, FC, 1982) |
| " The aim of the study is to evaluate the effect of simultaneously administered isoniazid (300 mg/day) and phenytoin (300 mg/day) on 60 patients with tuberculous meningitis or tuberculoma having seizures." | 5.17 | Phenotypic interaction of simultaneously administered isoniazid and phenytoin in patients with tuberculous meningitis or tuberculoma having seizures. ( Adole, PS; Kharbanda, PS; Sharma, S; Singh, A, 2013) |
| "Pyridoxine hydrochloride, the antidote for isonicotinic acid hydrazide (INH)--induced seizures, is available in solution at a concentration of 100 mg/mL at a pH of less than 3." | 5.09 | Intravenous pyridoxine-induced metabolic acidosis. ( Curry, SC; Graeme, KA; Lovecchio, F; Suchard, J; Wallace, KL, 2001) |
| " polytricha aqueous extract; maximal electroshock (MES)- and isoniazid (INH)-induced seizures in albino mice were used to screen for the extract's antiepileptic activity." | 3.91 | Aqueous Extract of Wood Ear Mushroom, Auricularia polytricha (Agaricomycetes), Demonstrated Antiepileptic Activity against Seizure Induced by Maximal Electroshock and Isoniazid in Experimental Animals. ( Agrawal, M; Awasthi, R; Dahiya, R; Dua, K; Gupta, G; Mishra, A; Pathak, S; Sharma, RK, 2019) |
| " Though atonic seizures were observed during the treatment, it disappeared after isoniazid discontinuation and pyridoxal phosphate administration." | 3.91 | Clinical findings and treatment of disseminated 'Mycobacterium avium subspecies hominissuis' infection in a domestic cat. ( Hatoya, S; Hirai, K; Kanegi, R; Nabetani, T; Sugiura, K; Tanaka, T; Wada, Y; Yasugi, M, 2019) |
| "Simultaneous administration of phenytoin and isoniazid (INH) in tuberculous meningitis (TBM) or tuberculoma patients with seizures results in higher plasma phenytoin level and thus phenytoin intoxication." | 3.83 | N-acetyltransferase 2 (NAT2) gene polymorphism as a predisposing factor for phenytoin intoxication in tuberculous meningitis or tuberculoma patients having seizures - A pilot study. ( Adole, PS; Kharbanda, PS; Sharma, S, 2016) |
| " And the potency of compound 14 against seizures induced by Pentylenetetrazole, Isoniazid, Thiosemicarbazide and 3-Mercaptopropionic acid in the chemical-induced seizure tests suggested that compound 14 displayed wide spectrum of activity in several models." | 3.79 | Synthesis and anticonvulsant activity evaluation of 6-substituted-[1,2,4]triazolo[3,4-a](tetrazolo[5,1-a])phthalazine derivatives. ( Bian, M; Deng, XQ; Gong, GH; Quan, ZS; Wei, CX, 2013) |
| " In addition, the potence of compound 1i against seizures induced by Pentylenetetrazole, Isoniazid, Thiosemicarbazide, 3-Mercaptopropionic acid, and Bicuculline in the chemical-induced seizure tests suggested that compound 1i displayed broad spectrum activity in several models, and it is likely to have several mechanisms of action including inhibiting voltage-gated ion channels and modulating GABAergic activity." | 3.77 | Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives. ( Deng, XQ; Quan, LN; Quan, ZS; Song, MX; Wei, CX, 2011) |
| " Here, we investigated pharmacologically the functional significance of taurine-induced increase in GAD expression by determining the threshold for kainic acid-induced seizures after partial inhibition of GAD activity with isoniazide." | 3.74 | Selective resistance of taurine-fed mice to isoniazide-potentiated seizures: in vivo functional test for the activity of glutamic acid decarboxylase. ( El Idrissi, A; L'Amoreaux, WJ, 2008) |
| " Furthermore, we tested nefopam for protection against both, maximal electroshock-induced seizures (MES), and isoniazid-induced seizures in mice." | 3.74 | Nefopam is more potent than carbamazepine for neuroprotection against veratridine in vitro and has anticonvulsant properties against both electrical and chemical stimulation. ( Desogus, CM; Fernández-Sánchez, MT; Ferrero-Gutiérrez, A; Groppetti, A; Manfredi, B; Novelli, A; Pérez-Gómez, A; Rossoni, G, 2007) |
| " Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma." | 3.73 | Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. ( Ekici, NZ; Kefi, A; Sakarya, M; Topcu, I; Yentur, EA, 2005) |
| "Both isoniazid (INH) and cefazolin (CEZ) can have serious adverse effects on the central nervous system (CNS), causing seizures." | 3.73 | Effect of isoniazid on the pharmacodynamics of cefazolin-induced seizures in rats. ( Ishiwata, Y; Nagata, M; Yasuhara, M, 2005) |
| "Isoniazid-induced seizures resulted in rhabdomyolysis and associated acute renal tubular necrosis in a dog." | 3.71 | Isoniazid-induced seizures with secondary rhabdomyolysis and associated acute renal failure in a dog. ( Haburjak, JJ; Spangler, WL, 2002) |
| "Rhabdomyolysis is one of the reported complications of isoniazid poisoning, but relevant data are limited." | 3.71 | Rhabdomyolysis in isoniazid poisoning. ( Corte-Maramba, NP; Makalinao, IR; Panganiban, LR, 2001) |
| " Diazepam, but not the synthetic flavonoids increased the latency to clonic seizures produced by isoniazid, thereby indicating that neither 6-bromoflavone nor 6-bromo-3'-nitroflavone display detectable intrinsic activity at GABA(A) receptors in vivo." | 3.70 | Pharmacological studies on synthetic flavonoids: comparison with diazepam. ( Griebel, G; Perrault, G; Sanger, DJ; Schoemaker, H; Tan, S, 1999) |
| "Isoniazid-induced seizures respond poorly to anticonvulsants but well to pyridoxine (Vitamin B6); theophylline produces difficult-to-treat seizures with substantial morbidity and mortality." | 3.70 | Seizures induced by theophylline and isoniazid in mice. ( Bonner, AB; Peterson, SL; Weir, MR, 1999) |
| " The onset of isoniazid-induced seizures in LEC rats at 9 weeks of age was significantly delayed compared with that in LE rats." | 3.70 | Increased abundance of GABAA receptor subunit mRNAs in the brain of Long-Evans Cinnamon rats, an animal model of Wilson's disease. ( Biggio, G; Floris, S; Follesa, P; Mallei, A; Mostallino, MC; Sanna, E, 1999) |
| "This study investigated the ability of hyperbaric exposure to antagonize ethanol's anticonvulsant effect on isoniazid (INH)-induced seizures." | 3.69 | Low-level hyperbaric antagonism of ethanol's anticonvulsant property in C57BL/6J mice. ( Alkana, RL; Davies, DL; Jones, BL; Mørland, J, 1994) |
| "To identify more potent anticonvulsant agents and to gain insights into the structural properties determining the potency of a new class of anticonvulsants, some 3a-substituted tetrahydropyrrolo[2,1-b]benzothiazol-1-ones (1a-d) and the thiazole and oxazole analogues (2a-c and 3a-c, respectively) have been synthesized and tested for anticonvulsant activity against isoniazid-induced seizures in rodents." | 3.69 | Synthesis and anticonvulsant activity of some 1,2,3,3a-tetrahydropyrrolo[2,1-b]-benzothiazol-, -thiazol- or -oxazol-1-ones in rodents. ( Biggio, G; Carotti, A; Cellamare, S; Franco, M; Ghiani, CA; Latrofa, A; Liso, G; Serra, M; Trapani, G; Tuligi, G, 1996) |
| "In an experimental condition of hyperthyroidism, obtained by repeated administration of triiodothyronine in adult rats (100 micrograms/kg/day, sc for 7 consecutive days), there is an increased susceptibility to the convulsant effect of isoniazid (300 mg/kg, ip) and picrotoxin (4 mg/kg, ip)." | 3.68 | Repeated administration of triiodothyronine enhances the susceptibility of rats to isoniazid- and picrotoxin-induced seizures. ( Bertolini, A; Marrama, D; Sandrini, M; Vergoni, AV, 1992) |
| "The anticonvulsant effects of felbamate alone or in combination with diazepam were investigated against maximal electroshock-, pentylenetetrazol-, isoniazid- and bicuculline-induced seizures in mice." | 3.68 | Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1991) |
| " Similarly, following pretreatment with intranigral isoniazid, neither severity nor latency to onset of seizures elicited by systemic injection of kainic acid (9 mg/kg) were modified." | 3.68 | Lack of proconvulsant action of GABA depletion in substantia nigra in several seizure models. ( Gale, K; Maggio, R; Sohn, E, 1991) |
| "To report a case of reversible seizures and mental status changes in a dialysis patient given preventive isoniazid therapy." | 3.68 | Reversible seizures and mental status changes in a dialysis patient on isoniazid preventive therapy. ( Asnis, DS; Bhat, JG; Melchert, AF, 1993) |
| " The present study aimed at investigating the effects of microgram doses of this benzodiazepine on i) the threshold doses of either pentylenetetrazole, picrotoxin or bicuculline required to induce seizures in mice and ii) the suppression of lever pressing for food induced by the delivery of one electric footshock every ten presses in rats pretreated or not with isoniazid (64 mg/kg IP)." | 3.67 | Microgram doses of diazepam do not induce proconvulsant or proconflict effects in rodents. ( Laporte, AM; Soubrié, P; Thiébot, MH, 1987) |
| " GSH and its related aminoacids as cysteine and glycine greatly decreased the duration of INH-induced seizures, while glutamic acid did not protect against convulsions caused by INH." | 3.67 | Anti-convulsant effects by reduced glutathione and related aminoacids in rats treated with isoniazid. ( Colombo-Zefinetti, G; Pinelli, A; Tofanetti, O; Trivulzio, S, 1988) |
| " Picrotoxin and pentylenetrazol-induced seizures were also blocked with corresponding ED50 values for clonic convulsions of 224." | 3.67 | Anticonvulsant activity of the nipecotic acid ester, (+/-)-m-nitrophenyl-3-piperidinecarboxylate. ( Crider, AM; Hinko, CN; Seibert, K, 1984) |
| "Isoniazid (INH) poisoning is a known cause of metabolic acidosis and seizures." | 3.67 | Complete recovery from severe metabolic acidosis associated with isoniazid poisoning in a young boy. ( Black, LE; Ros, SP, 1989) |
| " A significant sensitization to seizures induced by isoniazid, a drug known to inhibit GABAergic transmission, was also found to occur after long-term (25 days) withdrawal." | 3.67 | Behavioural and biochemical evidence for a long-lasting decrease in GABAergic function elicited by chronic administration of FG 7142. ( Biggio, G; Corda, MG; Giorgi, O, 1986) |
| "Amino acid concentrations were measured in the cortex, cerebellum and hippocampus of the mouse brain before and during seizures induced by isoniazid (250 mg/kg i." | 3.67 | The specific protective effect of diazepam and valproate against isoniazid-induced seizures is not correlated with increased GABA levels. ( Baltzer, V; Bernasconi, R; Jones, RS; Klein, M; Maître, L; Martin, P; Portet, C; Schmutz, M, 1985) |
| " The GABA-T inhibitor dose-dependently protected mice against isoniazid-induced seizures, simultaneously causing an increase in brain GABA concentrations." | 3.67 | Gamma-vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice. ( Bernasconi, R; Christen, P; Hafner, T; Klein, M; Martin, P; Portet, C; Schmutz, M, 1988) |
| "Pilocarpine, given intraperitoneally to rats, reproduces the neuropathological sequelae of temporal lobe epilepsy and provides a relevant animal model for studying mechanisms of buildup of convulsive activity and pathways operative in the generalization and propagation of seizures within the forebrain." | 3.67 | Susceptibility to seizures produced by pilocarpine in rats after microinjection of isoniazid or gamma-vinyl-GABA into the substantia nigra. ( Bortolotto, ZA; Cavalheiro, EA; De Moraes Mello, LE; Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Turski, WA, 1986) |
| ") protected against seizures induced by maximal electroshock and increased the incidence and severity of seizures induced by bicuculline, in rats." | 3.66 | Morphine potentiates seizures induced by GABA antagonists and attenuates seizures induced by electroshock in the rat. ( Foote, F; Gale, K, 1983) |
| "Caerulein, cholecystokinin octapeptide (CCK-8) and diazepam delayed the onset of seizures produced by harman and thiosemicarbazide (TSC)." | 3.66 | Anticonvulsant effects of caerulein, cholecystokinin octapeptide (CCK-8) and diazepam against seizures produced in mice by harman, thiosemicarbazide and isoniazid. ( Zetler, G, 1981) |
| " Isoniazide and picrotoxin were used to increase motor activity and induce seizures associated with an increase in cerebellar cGMP content." | 3.66 | Halothane effect on cGMP and control of motor activity in mouse cerebellum. ( Alpert, M; Triner, L; Verosky, M; Vulliemoz, Y, 1981) |
| "Large doses of pyridoxine recently have been shown to prevent the seizures and acidosis caused by ingestion of more than two to three grams of isoniazid." | 3.66 | Isoniazid overdose treated with high-dose pyridoxine. ( Wood, JP; Yarbrough, BE, 1983) |
| " The onset of generalized seizures induced by isoniazid (800 mg/kg) or by thiosemicarbazide (64 mg/kg) i." | 3.66 | Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats. ( Hamon, M; Hery, F; Jobert, A; Montastruc, JL; Soubrie, P; Thiebot, MH, 1980) |
| "The intramuscular injection of aminooxyacetic acid (AOAA) into mice elevated the concentration of gamma-aminobutyric acid (GABA) in the brain, inhibited glutamic acid decarboxylase activity and delayed the onset of isonicotinic acid hydrazide induced seizures." | 3.65 | A dual mechanism for the anticonvulsant action of aminooxyacetic acid. ( Peesker, SJ; Wood, JD, 1976) |
| " It protects mice against seizures induced by audiogenic stimuli, electroshock, thiosemicarbazide, isoniazid and strychnine." | 3.65 | Antiseizure activity of gamma-acetylenic gamma-aminobutyric acid: a catalytic irreversible inhibitor of gamma-aminobutyric acid transaminase. ( Jung, MJ; Schechter, PJ; Sjoerdsma, A; Tranier, Y, 1977) |
| "Levofloxacin is an effective bactericidal category III antitubercular drug." | 2.82 | Safety and efficacy of additional levofloxacin in tuberculous meningitis: A randomized controlled pilot study. ( Betai, S; Bhoi, SK; Kalita, J; Misra, UK, 2016) |
| "Seizures are commonly encountered in patients who do not have epilepsy." | 2.40 | Medical causes of seizures. ( Delanty, N; French, JA; Vaughan, CJ, 1998) |
| "Isoniazid has a low therapeutic margin and produces life threatening signs in dogs ingesting single 300 mg human tablets." | 2.39 | Treatment of acute isoniazid overdose in dogs. ( Barret, GH; Buck, WB; Holding, J; Knight, MK; Villar, D, 1995) |
| "Isoniazid overdose is a potentially fatal intoxication." | 2.39 | Isoniazid overdose: four case reports and review of the literature. ( Alvarez, FG; Guntupalli, KK, 1995) |
| "Isoniazid (INH) is a well-known therapeutic and preventive agent against tuberculosis." | 1.48 | Isoniazid-induced hepatotoxicity and neurotoxicity in rats investigated by ( Chen, C; Fan, JT; Fu, YH; Hong, W; Jiang, L; Li, MH; Ruan, LY; Wang, JS; Xing, YX; Zhao, H, 2018) |
| "She had no recurrence of seizures but had acute liver injury subsequently which gradually improved with supportive care." | 1.46 | Oral pyridoxine can substitute for intravenous pyridoxine in managing patients with severe poisoning with isoniazid and rifampicin fixed dose combination tablets: a case report. ( Dilrukshi, MDSA; Gnanathasan, CA; Ratnayake, CAP, 2017) |
| "We report a case of isoniazid induced convulsions in 35 years old male alcoholic and smoker patient receiving intensive phase therapy for pulmonary tuberculosis." | 1.42 | Isoniazid induced convulsions at therapeutic dose in an alcoholic and smoker patient. ( Aiwale, AS; Barvaliya, MJ; Jha, PR; Patel, UA; Tripathi, C, 2015) |
| "Most reported cases of isoniazid-induced convulsive seizures occurred as a result of an overdose due to attempted suicide." | 1.40 | Convulsive seizures with a therapeutic dose of isoniazid. ( Fujisawa, N; Harada, E; Hashisako, M; Ikematsu, Y; Miyagi, H; Tsubouchi, K, 2014) |
| "Isoniazid (INH) is an integral component of treatment of tuberculosis." | 1.38 | Seizures with single therapeutic dose of isoniazid. ( Behera, D; Kumar, L; Puri, MM; Vishwakarma, PD, 2012) |
| "Pyridoxine was given intravenously as an antidote." | 1.34 | [Isoniazid intoxication]. ( Cyran, J; Graf, J; Radunz, W; Scheffold, N, 2007) |
| "Antituberculous drugs are generally safe but can occasionally be associated with life-threatening complications." | 1.32 | Antituberculous therapy-induced toxicity. ( Abraham, OC; Bharat, A; Mathai, D; Subhash, HS; Vedkumar, M, 2003) |
| "She presented repetitive generalized convulsions with metabolic acidosis, treated with diazepam and 7." | 1.31 | [Acute isoniazid poisoning presenting convulsion and liver dysfunction]. ( Hamabe, Y; Kiyota, K, 2001) |
| "GABA is crucial in the generation of absence seizures." | 1.31 | Selective susceptibility to inhibitors of GABA synthesis and antagonists of GABA(A) receptor in rats with genetic absence epilepsy. ( Boehrer, A; Marescaux, C; Reibel, S; Simler, S; Vergnes, M, 2000) |
| "At isoniazid-induced generalized tonic-clonic seizures, a significant increase in both enzyme activities was observed in adult rat brain." | 1.31 | Influence of convulsants on rat brain activities of alanine aminotransferase and aspartate aminotransferase. ( Drsata, J; Haugvicová, R; Kubová, H; Mares, P; Netopilová, M, 2001) |
| "She was in respiratory failure, with seizures that could not be stopped with diazepam." | 1.29 | [Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose]. ( Adler, M; Girsh-Solomonovich, Z; Raikhlin-Eisenkraft, B, 1993) |
| "Alpidem is a new anxiolytic of imidazopyridine structure which has a high affinity for the omega 1 (BZ1) modulatory site of the GABAA receptor." | 1.29 | Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence. ( Morel, E; Perrault, G; Sanger, DJ; Zivkovic, B, 1993) |
| "One patient presented twice with seizures." | 1.29 | Acute isoniazid neurotoxicity in an urban hospital. ( Santucci, K; Shah, BR; Sinert, R; Steiner, P, 1995) |
| "Abecarnil was able to antagonize the convulsions elicited by isoniazid in diazepam-tolerant mice." | 1.29 | Antagonism of isoniazid-induced convulsions by abecarnil in mice tolerant to diazepam. ( Biggio, G; Ghiani, CA; Motzo, C; Porceddu, ML; Serra, M, 1995) |
| "Of 233 charts coded as involving seizures, 191 occurred in humans and were available for analysis." | 1.29 | Seizures associated with poisoning and drug overdose. ( Benowitz, NL; Blanc, PD; Dyer, JE; Kearney, TE; Olson, KR, 1993) |
| "Motor seizures elicited by isonicotinehydrazide (INH) were studied in 188 male albino rats aged from 5 days to adulthood." | 1.28 | Ontogenetic development of isonicotinehydrazide-induced seizures in rats. ( Mares, P; Trojan, S, 1991) |
| "The isoniazid-induced increase in [35S]TBPS binding was markedly potentiated by foot-shock stress." | 1.28 | Foot-shock stress enhances the increase of [35S]TBPS binding in the rat cerebral cortex and the convulsions induced by isoniazid. ( Biggio, G; Concas, A; Foddi, C; Sanna, E; Serra, M, 1991) |
| "The antiseizure activity of the glia-selective GABA uptake inhibitor, 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]azepin-3-ol (THAO), was evaluated in rats in models of acute chemoconvulsion." | 1.28 | Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures. ( Gonsalves, SF; Harbaugh, RE; Krogsgaard-Larsen, P; Schousboe, A; Twitchell, B, 1989) |
| "Zolpidem is a new, short-acting hypnotic of imidazopyridine structure which binds selectively to a subpopulation of receptors involved in the action of benzodiazepines [omega 1 (BZ1) sites of the gamma-aminobutyric acidA receptors]." | 1.28 | Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem. ( Morel, E; Perrault, G; Sanger, DJ; Zivkovic, B, 1992) |
| "This diazepam-elicited increase in Bmax is blocked in mice receiving the diazepam antagonist Ro 15-1788 (ethyl-8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5a]-[1,4] benzodiazepine-3-carboxylate)." | 1.27 | Increase in the Bmax of gamma-aminobutyric acid-A recognition sites in brain regions of mice receiving diazepam. ( Costa, E; Ferrero, P; Guidotti, A, 1984) |
| "One patient presented with oliguria and coma whereas seizures were the dominant feature in the second case." | 1.27 | Acute isoniazid toxicity--report of 2 cases and review of literature. ( Gilhotra, R; Malik, SK; Sharma, BK; Singh, S, 1987) |
| "D-halothane and halothane were equipotent on both parameters." | 1.27 | Deuterated halothane--anesthetic potency, anticonvulsant activity, and effect on cerebellar cyclic guanosine 3',5'-monophosphate. ( Hamm, MW; Krishna, G; Triner, L; Verosky, M; Vulliemoz, Y, 1984) |
| "THPO was also effective in preventing seizures induced in epileptic chicks by intermittent photic stimulation." | 1.27 | Anticonvulsant activity of the glial-selective GABA uptake inhibitor, THPO. ( Johnson, DD; Krogsgaard-Larsen, P; Schousboe, A; Wood, JD, 1983) |
| "In all patients generalized seizures and metabolic acidosis developed." | 1.27 | Isoniazid overdose in the Cambodian population of Olmsted County, Minnesota. ( Blanchard, PD; Hurt, RD; McAlpine, DE; Yao, JD, 1986) |
| ", failed to produce any relevant shift of the isoniazid dose-response curves to the left (proconvulsant) or to the right (anticonvulsant)." | 1.27 | Isoniazid-induced convulsions in rats: effects of Ro 15-1788 and beta-CCE. ( Biry, P; Pieri, L, 1985) |
| "Isoniazid is a useful chemical convulsant in that metabolic events associated with the preseizure state can be easily examined." | 1.26 | Isoniazid induced seizures and cerebral cortical and cerebellar energy metabolism. ( Abel, MS; McCandless, DW; Schwartzenburg, FC, 1982) |
| "Only slight decreases in seizure responsiveness were observed with strychnine induced seizures at either 1 or 14 h." | 1.26 | Effect of trimethyltin on chemically-induced seizures. ( Costa, LG; Doctor, SV; Murphy, SD, 1982) |
| "We treated five isoniazid-overdosed patients each with a single dose of pyridoxine hydrochloride equivalent to the gram amount of isoniazid ingested and compared their outcome with that of 41 patients from the literature who received little or no pyridoxine." | 1.26 | Single high-dose pyridoxine treatment for isoniazid overdose. ( Lacouture, PG; Lovejoy, FH; Wason, S, 1981) |
| "Each had an obvious cause for repeated seizures." | 1.26 | Postictal pleocytosis. ( Schmidley, JW; Simon, RP, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 153 (64.02) | 18.7374 |
| 1990's | 42 (17.57) | 18.2507 |
| 2000's | 20 (8.37) | 29.6817 |
| 2010's | 21 (8.79) | 24.3611 |
| 2020's | 3 (1.26) | 2.80 |
| Authors | Studies |
|---|---|
| Shukurova, S | 1 |
| Sadek, R | 1 |
| Mekawy, N | 1 |
| Bendaoud, M | 1 |
| Yachou, Y | 1 |
| Mamchyn, A | 1 |
| El Idrissi, A | 2 |
| Kanegi, R | 1 |
| Yasugi, M | 1 |
| Nabetani, T | 1 |
| Tanaka, T | 1 |
| Wada, Y | 1 |
| Hirai, K | 1 |
| Sugiura, K | 1 |
| Hatoya, S | 1 |
| Kalita, J | 2 |
| Misra, UK | 2 |
| Singh, VK | 1 |
| Pandey, PC | 1 |
| Thomas, J | 1 |
| Polat, E | 1 |
| Senel, S | 1 |
| Dilrukshi, MDSA | 1 |
| Ratnayake, CAP | 1 |
| Gnanathasan, CA | 1 |
| Glatstein, M | 1 |
| Carbell, G | 1 |
| Scolnik, D | 1 |
| Rimon, A | 1 |
| Banerji, S | 1 |
| Hoyte, C | 1 |
| Mahendran, G | 1 |
| Vijayan, R | 1 |
| Mozhokina, GN | 1 |
| Elistratova, NA | 1 |
| Ruan, LY | 1 |
| Fan, JT | 1 |
| Hong, W | 1 |
| Zhao, H | 1 |
| Li, MH | 1 |
| Jiang, L | 1 |
| Fu, YH | 1 |
| Xing, YX | 1 |
| Chen, C | 1 |
| Wang, JS | 1 |
| Gupta, G | 2 |
| Pathak, S | 1 |
| Dahiya, R | 1 |
| Awasthi, R | 1 |
| Mishra, A | 1 |
| Sharma, RK | 1 |
| Agrawal, M | 2 |
| Dua, K | 1 |
| Pisu, MG | 2 |
| Boero, G | 1 |
| Garau, A | 1 |
| Casula, C | 1 |
| Cisci, S | 1 |
| Biggio, F | 1 |
| Concas, A | 7 |
| Follesa, P | 3 |
| Maciocco, E | 3 |
| Porcu, P | 1 |
| Serra, M | 8 |
| Uzman, S | 1 |
| Uludağ Yanaral, T | 1 |
| Toptaş, M | 1 |
| Koç, A | 1 |
| Taş, A | 1 |
| Bican, G | 1 |
| Adole, PS | 2 |
| Singh, A | 1 |
| Kharbanda, PS | 2 |
| Sharma, S | 2 |
| Muñoz Aguilar, G | 1 |
| Alcón Sáez, JJ | 1 |
| Gómez Zafra, R | 1 |
| Domingo Triadó, I | 1 |
| Tsubouchi, K | 1 |
| Ikematsu, Y | 1 |
| Hashisako, M | 1 |
| Harada, E | 1 |
| Miyagi, H | 1 |
| Fujisawa, N | 1 |
| Aiwale, AS | 1 |
| Patel, UA | 1 |
| Barvaliya, MJ | 1 |
| Jha, PR | 1 |
| Tripathi, C | 1 |
| Bhoi, SK | 1 |
| Betai, S | 1 |
| Wretman, M | 1 |
| Agrawal, RL | 1 |
| Dwivedi, NC | 1 |
| Jain, S | 1 |
| Agrawal, A | 1 |
| L'Amoreaux, WJ | 1 |
| Guan, LP | 1 |
| Wei, CX | 3 |
| Deng, XQ | 3 |
| Sui, X | 1 |
| Piao, HR | 1 |
| Quan, ZS | 3 |
| Quan, LN | 1 |
| Song, MX | 1 |
| Kumar, R | 1 |
| Sharma, AK | 1 |
| Saraf, SA | 1 |
| Gupta, R | 1 |
| Puri, MM | 1 |
| Kumar, L | 2 |
| Vishwakarma, PD | 1 |
| Behera, D | 1 |
| Kazmi, I | 1 |
| Afzal, M | 1 |
| Anwar, F | 1 |
| Bian, M | 1 |
| Gong, GH | 1 |
| Knapp, JF | 1 |
| Johnson, T | 1 |
| Alander, S | 1 |
| Shannon, M | 1 |
| McElroy, EA | 1 |
| Liebelt, EL | 1 |
| Bharat, A | 1 |
| Vedkumar, M | 1 |
| Subhash, HS | 1 |
| Abraham, OC | 1 |
| Mathai, D | 1 |
| REILLY, RH | 1 |
| KILLAM, KF | 3 |
| JENNEY, EH | 1 |
| MARSHALL, WH | 1 |
| TAUSIG, T | 1 |
| APTER, NS | 1 |
| PFEIFFER, CC | 1 |
| COGNI, G | 1 |
| MIHICH, E | 1 |
| CEDRANGOLO, F | 3 |
| GIOIA, A | 3 |
| BAGNULO, R | 3 |
| PERITI, P | 4 |
| BUFFONI NARDINI, F | 2 |
| COSTA, E | 8 |
| FERRARI, W | 1 |
| MANCINI, MA | 1 |
| KLINGHARDT, GW | 1 |
| RADENBACH, KL | 1 |
| MROWKA, S | 1 |
| PORCINO, F | 1 |
| PLEASURE, H | 1 |
| LUKAVSKY, J | 1 |
| PETROVICKY, O | 1 |
| LIVINGSTON, S | 1 |
| PETERSEN, D | 1 |
| PECK, JL | 1 |
| KLISSIUNIS, N | 1 |
| FOGEL DE KORC, E | 1 |
| BOTTINELLI, MD | 1 |
| BELEN DE BRIDA, D | 1 |
| KNOLL, J | 1 |
| KELEMEN, K | 1 |
| KNOLL, B | 1 |
| NIEVEL, JG | 1 |
| DELLA PIETRA, G | 1 |
| CAPANO, V | 1 |
| DE LORENZO, F | 1 |
| ROGLIANI, C | 1 |
| WEBER, B | 2 |
| LABORIT, H | 2 |
| BARRETO, RC | 1 |
| MANO, DB | 1 |
| ERDMANN, G | 1 |
| KUELZ, J | 1 |
| NIAUSSAT, MM | 1 |
| MEREU, T | 1 |
| MORETTI, M | 1 |
| STARKE, H | 1 |
| WILLIAMS, S | 1 |
| SPILLANE, JD | 1 |
| RAJTAR-LEONTIEW, Z | 1 |
| ZALEWSKI, T | 1 |
| TODD, RM | 1 |
| NEVILLE, JG | 1 |
| BESSON, H | 1 |
| DEBAY, A | 1 |
| BONAVITA, V | 2 |
| GUARNERI, R | 1 |
| MONACO, P | 1 |
| ADAMS, P | 1 |
| WHITE, C | 1 |
| NELSON, LG | 1 |
| SAKAI, K | 1 |
| YOSHIKAWA, N | 1 |
| KINOSHITA, Y | 1 |
| OSHIKA, H | 1 |
| NAKAI, K | 1 |
| FALK, A | 1 |
| LISSAC, J | 1 |
| POCIDALO, JJ | 1 |
| SACHS, C | 1 |
| KOHLI, RP | 1 |
| KISHOR, K | 1 |
| DEVADATTA, S | 1 |
| KOGUCHI, H | 1 |
| Ishiwata, Y | 1 |
| Nagata, M | 1 |
| Yasuhara, M | 1 |
| McLay, RN | 1 |
| Drake, A | 1 |
| Rayner, T | 1 |
| Sanna, E | 4 |
| Busonero, F | 1 |
| Talani, G | 1 |
| Mostallino, MC | 4 |
| Mura, ML | 1 |
| Biggio, G | 12 |
| Topcu, I | 1 |
| Yentur, EA | 1 |
| Kefi, A | 1 |
| Ekici, NZ | 1 |
| Sakarya, M | 1 |
| Novelli, A | 1 |
| Groppetti, A | 1 |
| Rossoni, G | 1 |
| Manfredi, B | 1 |
| Ferrero-Gutiérrez, A | 1 |
| Pérez-Gómez, A | 1 |
| Desogus, CM | 1 |
| Fernández-Sánchez, MT | 1 |
| Graf, J | 1 |
| Scheffold, N | 1 |
| Radunz, W | 1 |
| Cyran, J | 1 |
| Bonasera, N | 1 |
| Smorto, M | 1 |
| Noel, PR | 1 |
| Worden, AN | 1 |
| Palmer, AC | 1 |
| Bernardi, M | 1 |
| Bertolini, A | 2 |
| Ferrari, F | 1 |
| Greggia, A | 1 |
| Szczerbiński, A | 1 |
| Soubrie, P | 2 |
| Thiebot, MH | 2 |
| Jobert, A | 1 |
| Montastruc, JL | 1 |
| Hery, F | 1 |
| Hamon, M | 1 |
| Walther, JU | 1 |
| Triner, L | 2 |
| Vulliemoz, Y | 2 |
| Verosky, M | 2 |
| Alpert, M | 1 |
| Zetler, G | 1 |
| Corda, MG | 3 |
| Guidotti, A | 6 |
| Hamm, MW | 1 |
| Krishna, G | 1 |
| Ferrero, P | 1 |
| Salis, M | 1 |
| Nurchi, V | 1 |
| Crisponi, G | 1 |
| Toffano, G | 1 |
| Mazzari, S | 1 |
| Zanotti, A | 1 |
| Bruni, A | 1 |
| Hinko, CN | 1 |
| Seibert, K | 1 |
| Crider, AM | 1 |
| Yarbrough, BE | 1 |
| Wood, JP | 1 |
| Foote, F | 1 |
| Gale, K | 2 |
| McCandless, DW | 2 |
| Abel, MS | 1 |
| Schwartzenburg, FC | 1 |
| Wood, JD | 13 |
| Johnson, DD | 1 |
| Krogsgaard-Larsen, P | 2 |
| Schousboe, A | 2 |
| Youssef, W | 1 |
| Cahuana, A | 1 |
| Feijoo, B | 1 |
| Pou, J | 1 |
| Rosenkranz, RP | 2 |
| Miller, J | 1 |
| Robinson, A | 1 |
| Percy, AK | 1 |
| Clement, JG | 1 |
| Lee, MJ | 1 |
| Block, SH | 1 |
| Doctor, SV | 1 |
| Costa, LG | 1 |
| Murphy, SD | 1 |
| Doherty, T | 1 |
| Schmidley, JW | 1 |
| Simon, RP | 1 |
| Czuczwar, SJ | 1 |
| Turski, L | 2 |
| Kleinrok, Z | 1 |
| Satoh, T | 1 |
| Hara, S | 1 |
| Numata, Y | 1 |
| Kitagawa, H | 1 |
| Wason, S | 1 |
| Lacouture, PG | 1 |
| Lovejoy, FH | 1 |
| Kendall, DA | 1 |
| Fox, DA | 1 |
| Enna, SJ | 1 |
| Wood, ER | 1 |
| Lahori, UC | 1 |
| Sharma, DB | 1 |
| Blowey, DL | 1 |
| Johnson, D | 1 |
| Verjee, Z | 1 |
| Shah, BR | 1 |
| Santucci, K | 1 |
| Sinert, R | 1 |
| Steiner, P | 1 |
| Aggarwal, P | 1 |
| Davies, DL | 1 |
| Mørland, J | 1 |
| Jones, BL | 2 |
| Alkana, RL | 2 |
| Perrault, G | 3 |
| Morel, E | 2 |
| Sanger, DJ | 3 |
| Zivkovic, B | 2 |
| Biggs, CS | 1 |
| Pearce, BR | 1 |
| Fowler, LJ | 1 |
| Whitton, PS | 1 |
| Auta, J | 2 |
| Romeo, E | 2 |
| Kozikowski, A | 1 |
| Ma, D | 2 |
| Ghiani, CA | 3 |
| Motzo, C | 2 |
| Cuccheddu, T | 3 |
| Floris, S | 3 |
| Giusti, P | 1 |
| Olson, KR | 1 |
| Kearney, TE | 1 |
| Dyer, JE | 1 |
| Benowitz, NL | 1 |
| Blanc, PD | 1 |
| Santoro, G | 1 |
| Mascia, MP | 2 |
| Dazzi, L | 1 |
| Ongini, E | 1 |
| Adler, M | 1 |
| Girsh-Solomonovich, Z | 1 |
| Raikhlin-Eisenkraft, B | 1 |
| Cossu, A | 1 |
| Colombo, G | 1 |
| Asnis, DS | 1 |
| Bhat, JG | 1 |
| Melchert, AF | 1 |
| Alvarez, FG | 1 |
| Guntupalli, KK | 1 |
| Porceddu, ML | 1 |
| Villar, D | 1 |
| Knight, MK | 1 |
| Holding, J | 1 |
| Barret, GH | 1 |
| Buck, WB | 1 |
| Kurbasic, MP | 1 |
| Badgett, JT | 1 |
| Chang, YD | 1 |
| Yang, CC | 1 |
| Lin, TJ | 1 |
| Ger, J | 1 |
| Deng, JF | 1 |
| Perra, C | 2 |
| Lener, R | 1 |
| Roscetti, G | 1 |
| Barbaccia, ML | 1 |
| Purdy, RH | 1 |
| Satta, S | 1 |
| Trapani, G | 1 |
| Franco, M | 1 |
| Latrofa, A | 1 |
| Carotti, A | 1 |
| Cellamare, S | 1 |
| Tuligi, G | 1 |
| Liso, G | 1 |
| Martin, JR | 1 |
| Moreau, JL | 1 |
| Jenck, F | 1 |
| Pieri, L | 2 |
| Delanty, N | 1 |
| Vaughan, CJ | 1 |
| French, JA | 1 |
| Mallei, A | 1 |
| Bonner, AB | 1 |
| Peterson, SL | 1 |
| Weir, MR | 1 |
| Griebel, G | 1 |
| Tan, S | 1 |
| Schoemaker, H | 1 |
| Hahn, IH | 1 |
| Varney, S | 1 |
| Temmerman, W | 1 |
| Dhondt, A | 1 |
| Vandewoude, K | 1 |
| Vergnes, M | 1 |
| Boehrer, A | 1 |
| Reibel, S | 1 |
| Simler, S | 1 |
| Marescaux, C | 1 |
| Kiyota, K | 1 |
| Hamabe, Y | 1 |
| Panganiban, LR | 1 |
| Makalinao, IR | 1 |
| Corte-Maramba, NP | 1 |
| Lovecchio, F | 1 |
| Curry, SC | 1 |
| Graeme, KA | 1 |
| Wallace, KL | 1 |
| Suchard, J | 1 |
| Steinmann, RA | 1 |
| Rickel, MK | 1 |
| Ireland, JW | 1 |
| Aoki, B | 1 |
| Netopilová, M | 1 |
| Haugvicová, R | 1 |
| Kubová, H | 1 |
| Drsata, J | 1 |
| Mares, P | 3 |
| Haburjak, JJ | 1 |
| Spangler, WL | 1 |
| Chin, L | 2 |
| Sievers, ML | 3 |
| Herrier, RN | 3 |
| Picchioni, AL | 2 |
| Mao, CC | 2 |
| Suria, A | 1 |
| Feussner, GK | 1 |
| Lust, WD | 2 |
| Passonneau, JV | 1 |
| Matthews, WD | 1 |
| McCafferty, GP | 1 |
| Rokyta, R | 1 |
| Russell, MP | 1 |
| Kurylo, E | 1 |
| Newstead, JD | 1 |
| Matsuda, M | 2 |
| Abe, M | 1 |
| Hoshino, M | 1 |
| Sakurai, T | 1 |
| Lehmann, A | 1 |
| Laird, HE | 1 |
| Schechter, PJ | 1 |
| Tranier, Y | 1 |
| Jung, MJ | 1 |
| Sjoerdsma, A | 1 |
| Lembeck, F | 1 |
| Beubler, E | 1 |
| Frey, HH | 1 |
| Gorecki, DK | 1 |
| Peesker, SJ | 9 |
| Horton, RW | 1 |
| Meldrum, BS | 2 |
| McKenzie, SA | 1 |
| Macnab, AJ | 1 |
| Katz, G | 1 |
| Bear, ES | 1 |
| Hoffman, PF | 1 |
| Siegel, SR | 1 |
| Randal, RE | 1 |
| Coyer, JR | 1 |
| Nicholson, DP | 1 |
| Murakami, Y | 1 |
| Kozikowski, AP | 1 |
| Papadopoulos, V | 1 |
| Puia, G | 1 |
| Bernasconi, R | 3 |
| Martin, P | 3 |
| Steulet, AF | 1 |
| Portet, C | 3 |
| Leonhardt, T | 1 |
| Schmutz, M | 3 |
| Sandrini, M | 1 |
| Marrama, D | 1 |
| Vergoni, AV | 1 |
| Maggio, R | 1 |
| Sohn, E | 1 |
| Gordon, R | 1 |
| Gels, M | 1 |
| Diamantis, W | 1 |
| Sofia, RD | 1 |
| Hollinger, M | 1 |
| Orlandi, M | 1 |
| Lecca, D | 1 |
| Carboni, G | 1 |
| Frau, V | 1 |
| Giorgi, O | 2 |
| Trojan, S | 1 |
| Loubser, PG | 1 |
| Foddi, C | 1 |
| Kobayashi, LS | 1 |
| Finn, DA | 1 |
| Syapin, PJ | 1 |
| Bredemann, JA | 1 |
| Krechel, SW | 1 |
| Eggers, GW | 1 |
| Watkins, RC | 1 |
| Hambrick, EL | 1 |
| Benjamin, G | 1 |
| Chavda, SN | 1 |
| Singhi, PD | 1 |
| Pereira, BJ | 1 |
| Singh, U | 1 |
| Sakhuja, V | 1 |
| Chugh, KS | 1 |
| Gonsalves, SF | 1 |
| Twitchell, B | 1 |
| Harbaugh, RE | 1 |
| Black, LE | 1 |
| Ros, SP | 1 |
| Wall, GM | 1 |
| Baker, JK | 1 |
| Paul, V | 1 |
| Krishnamoorthy, MS | 1 |
| Pocchiari, M | 1 |
| Masullo, C | 1 |
| Gibbs, CJ | 1 |
| Gajdusek, DC | 1 |
| Pinelli, A | 1 |
| Trivulzio, S | 1 |
| Colombo-Zefinetti, G | 1 |
| Tofanetti, O | 1 |
| Laporte, AM | 1 |
| Orlowski, JP | 1 |
| Paganini, EP | 1 |
| Pippenger, CE | 1 |
| Klein, M | 2 |
| Christen, P | 1 |
| Hafner, T | 1 |
| Gilhotra, R | 1 |
| Malik, SK | 1 |
| Singh, S | 1 |
| Sharma, BK | 1 |
| Siefkin, AD | 1 |
| Albertson, TE | 1 |
| Corbett, MG | 1 |
| Cavalheiro, EA | 1 |
| Schwarz, M | 1 |
| Turski, WA | 1 |
| De Moraes Mello, LE | 1 |
| Bortolotto, ZA | 1 |
| Klockgether, T | 1 |
| Sontag, KH | 1 |
| Spalding, CT | 1 |
| Buss, WC | 1 |
| Blanchard, PD | 1 |
| Yao, JD | 1 |
| McAlpine, DE | 1 |
| Hurt, RD | 1 |
| Biry, P | 1 |
| Maître, L | 1 |
| Jones, RS | 1 |
| Baltzer, V | 1 |
| Pellock, JM | 1 |
| Howell, J | 1 |
| Kendig, EL | 1 |
| Baker, H | 1 |
| Balzano, E | 1 |
| Gadea, M | 1 |
| Naquet, R | 2 |
| Kar, PP | 2 |
| Matin, MA | 2 |
| Mellerio, F | 2 |
| Bleandonu, G | 2 |
| Boye, J | 2 |
| Mrozikiewicz, A | 1 |
| Strzyzewski, W | 1 |
| Reinken, L | 1 |
| Saad, SF | 1 |
| Gubanova, GF | 1 |
| Casey, RE | 1 |
| Mottram, PE | 1 |
| Johnson, PB | 1 |
| Hoffman, JE | 1 |
| Seidell, MA | 1 |
| Friedman, SA | 1 |
| Oehme, P | 1 |
| Hartmann, R | 1 |
| Friedrich, U | 1 |
| Schwarz, C | 1 |
| Komissarenko, BT | 1 |
| Terman, DS | 1 |
| Teitelbaum, DT | 1 |
| Földi, M | 2 |
| Zoltán, OT | 2 |
| Maurer, M | 1 |
| Abrahams, DE | 1 |
| Glogner, P | 1 |
| Vogt, O | 1 |
| Lange, H | 1 |
| Phatak, AT | 1 |
| Shah, SH | 1 |
| Bruncsák, A | 1 |
| Timár, S | 1 |
| Kosower, NS | 1 |
| Rock, RA | 1 |
| Dimitriu, CG | 1 |
| Klein, S | 1 |
| Cartier, F | 1 |
| Curtes, JP | 1 |
| Müller, F | 1 |
| María Palermo, F | 1 |
| Alberto Iannello, J | 1 |
| Klein, A | 1 |
| Iwainsky, H | 1 |
| Wiezorek, WD | 1 |
7 reviews available for isoniazid and Seizures
| Article | Year |
|---|---|
Isoniazid overdose: four case reports and review of the literature.
Topics: Acidosis; Adolescent; Adult; Antitubercular Agents; Drug Overdose; Female; Humans; Isoniazid; Male; | 1995 |
Treatment of acute isoniazid overdose in dogs.
Topics: Administration, Oral; Animals; Anticonvulsants; Antitubercular Agents; Cats; Diazepam; Dog Diseases; | 1995 |
Medical causes of seizures.
Topics: Acute Kidney Injury; Anticonvulsants; Antitubercular Agents; Blood Pressure; Brain Diseases; Broncho | 1998 |
Acute isoniazid intoxication: seizures, acidosis and coma.
Topics: Acidosis; Acute Disease; Adolescent; Antitubercular Agents; Coma; Diagnosis, Differential; Drug Over | 1999 |
New concepts on the mechanism of action of benzodiazepines.
Topics: Animals; Benzodiazepines; Cerebellum; Chlordiazepoxide; Cyclic AMP; Diazepam; gamma-Aminobutyric Aci | 1975 |
Evidence for involvement of GABA in the action of benzodiazepines: studies on rat cerebellum.
Topics: Aminobutyrates; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebellum; Cyclic GMP; gamma-Aminobu | 1975 |
[Scope and effect of vitamin B6 in newborn infants and children].
Topics: Amino Acids; Anemia, Hypochromic; Aspartate Aminotransferases; Brain; Coenzymes; Drug Antagonism; Fe | 1974 |
3 trials available for isoniazid and Seizures
| Article | Year |
|---|---|
Phenotypic interaction of simultaneously administered isoniazid and phenytoin in patients with tuberculous meningitis or tuberculoma having seizures.
Topics: Acetylation; Adult; Drug Interactions; Female; Humans; Isoniazid; Male; Phenotype; Phenytoin; Seizur | 2013 |
Safety and efficacy of additional levofloxacin in tuberculous meningitis: A randomized controlled pilot study.
Topics: Adolescent; Adult; Aged; Antitubercular Agents; Disability Evaluation; Drug Therapy, Combination; Et | 2016 |
Intravenous pyridoxine-induced metabolic acidosis.
Topics: Acidosis; Adult; Antidotes; Antitubercular Agents; Blood Gas Analysis; Cross-Over Studies; Drug Moni | 2001 |
229 other studies available for isoniazid and Seizures
| Article | Year |
|---|---|
Electrophysiological Evidence for Anti-epileptic Property of Taurine.
Topics: Amino Acids; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Isoniazid; Ka | 2022 |
Clinical findings and treatment of disseminated 'Mycobacterium avium subspecies hominissuis' infection in a domestic cat.
Topics: Animals; Anti-Bacterial Agents; Cat Diseases; Cats; Drug Therapy, Combination; Isoniazid; Liver; Lun | 2019 |
Inclusion of Mechanical Ventilation in Severity Staging of Tuberculous Meningitis Improves Outcome Prediction.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Antitubercular Agents; Child; Child, Preschool; Consciousn | 2020 |
Suicide attempt with isoniazid in adolescents receiving tuberculous prophylaxis: three cases.
Topics: Adolescent; Antitubercular Agents; Child; Humans; Isoniazid; Pyridoxine; Seizures; Suicide, Attempte | 2021 |
Oral pyridoxine can substitute for intravenous pyridoxine in managing patients with severe poisoning with isoniazid and rifampicin fixed dose combination tablets: a case report.
Topics: Administration, Oral; Antidotes; Antitubercular Agents; Diazepam; Drug Combinations; Female; Humans; | 2017 |
Pyridoxine for the treatment of isoniazid-induced seizures in intentional ingestions: The experience of a national poison center.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Antitubercular Agents; Female; Humans; Isoniaz | 2018 |
Neuropharmacological and molecular docking studies of xanthones from Swertia corymbosa.
Topics: Animals; Anticonvulsants; Anxiety; Electroshock; Epilepsy; Isoniazid; Male; Maze Learning; Mice; Mol | 2018 |
Experimental Substantiation of Taurine Use in Prophylaxis of Isoniazid-Induced Neurotoxic Reactions.
Topics: Animals; Anticonvulsants; Antitubercular Agents; Drug Combinations; Drug Synergism; Female; Isoniazi | 2016 |
Isoniazid-induced hepatotoxicity and neurotoxicity in rats investigated by
Topics: Animals; Antitubercular Agents; Behavior, Animal; Biomarkers; Brain; Chemical and Drug Induced Liver | 2018 |
Aqueous Extract of Wood Ear Mushroom, Auricularia polytricha (Agaricomycetes), Demonstrated Antiepileptic Activity against Seizure Induced by Maximal Electroshock and Isoniazid in Experimental Animals.
Topics: Agaricales; Animals; Anticonvulsants; Antitubercular Agents; Biological Products; Dose-Response Rela | 2019 |
Are preconceptional stressful experiences crucial elements for the aetiology of autism spectrum disorder? Insights from an animal model.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Brain-Derived Neurotrophic Factor; Disease Mode | 2019 |
Acute isoniazid intoxication: an uncommon cause of convulsion, coma and acidosis.
Topics: Acidosis; Antitubercular Agents; Coma; Humans; Infusions, Intravenous; Isoniazid; Male; Pyridoxine; | 2013 |
[Acute isoniazid poisoning: seizure in a patient on anti-tuberculosis treatment].
Topics: Acute Disease; Antitubercular Agents; Child, Preschool; Humans; Isoniazid; Male; Seizures; Tuberculo | 2014 |
Convulsive seizures with a therapeutic dose of isoniazid.
Topics: Aged, 80 and over; Antitubercular Agents; Female; Humans; Isoniazid; Seizures | 2014 |
Isoniazid induced convulsions at therapeutic dose in an alcoholic and smoker patient.
Topics: Adult; Alcoholism; Anticonvulsants; Antitubercular Agents; Humans; Isoniazid; Male; Pyridoxine; Risk | 2015 |
N-acetyltransferase 2 (NAT2) gene polymorphism as a predisposing factor for phenytoin intoxication in tuberculous meningitis or tuberculoma patients having seizures - A pilot study.
Topics: Acetylation; Adult; Arylamine N-Acetyltransferase; Drug Combinations; Drug-Related Side Effects and | 2016 |
[Overdose of tuberculosis drugs common among young asylum seekers].
Topics: Adolescent; Antitubercular Agents; Child; Drug Overdose; Humans; Isoniazid; Refugees; Seizures | 2016 |
Accidental isoniazid poisoning--a report.
Topics: Acidosis; Adolescent; Adult; Antitubercular Agents; Drug Overdose; Electroencephalography; Gastric L | 2008 |
Selective resistance of taurine-fed mice to isoniazide-potentiated seizures: in vivo functional test for the activity of glutamic acid decarboxylase.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Gene Expre | 2008 |
Synthesis and anticonvulsant activity of N-(2-hydroxyethyl) cinnamamide derivatives.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Cinnamates; Electroshock; Isoniazid; Mice; Penty | 2009 |
Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Electroshock; Isoniazid; Mice; Pent | 2011 |
CNS activity of aqueous extract of root of Cissus quadrangularis Linn. (Vitaceae).
Topics: Acute Pain; Analgesics; Animals; Anticonvulsants; Central Nervous System; Central Nervous System Age | 2010 |
Seizures with single therapeutic dose of isoniazid.
Topics: Aged; Antitubercular Agents; Drug Therapy, Combination; Humans; Isoniazid; Male; Seizures; Tuberculo | 2012 |
Antiepileptic potential of ursolic acid stearoyl glucoside by GABA receptor stimulation.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, | 2012 |
Synthesis and anticonvulsant activity evaluation of 6-substituted-[1,2,4]triazolo[3,4-a](tetrazolo[5,1-a])phthalazine derivatives.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Electroshock; Heterocyclic Compounds, 3-Ring; Is | 2013 |
Seizures in a 13-year-old girl.
Topics: Acidosis; Adolescent; Antitubercular Agents; Asia, Southeastern; Communication Barriers; Diagnosis, | 2003 |
Toxic seizures in children: case scenarios and treatment strategies.
Topics: Adolescent; Camphor; Child, Preschool; Cocaine; Drug Interactions; Emergencies; Female; GABA Antagon | 2003 |
Antituberculous therapy-induced toxicity.
Topics: Adult; Antitubercular Agents; Drug Therapy, Combination; Fever; Humans; Isoniazid; Male; Pyrazinamid | 2003 |
Convulsant effects of isoniazid.
Topics: Convulsants; Convulsive Therapy; Humans; Isoniazid; Niacin; Nicotinic Acids; Seizures | 1953 |
[Explication of antagonistic action of certain drugs toward preparations of isonicotinic acid hydrazide group producing convulsions].
Topics: Hostility; Hypnotics and Sedatives; Isomerism; Isoniazid; Niacin; Nicotinic Acids; Seizures | 1953 |
[Decreased toxicity of isonicotinic acid hydrazide in association with glutamic acid].
Topics: Glutamates; Glutamic Acid; Isomerism; Isoniazid; Niacin; Nicotinic Acids; Seizures | 1953 |
[Decreased toxicity of isonicotinic acid hydrazide in association with glutamic acid].
Topics: Glutamates; Glutamic Acid; Isomerism; Isoniazid; Niacin; Nicotinic Acids; Seizures | 1953 |
[Decreased toxicity of isonicotinic acid hydrazide in association with glutamic acid].
Topics: Glutamates; Glutamic Acid; Isomerism; Isoniazid; Niacin; Nicotinic Acids; Seizures | 1953 |
[Isoniazid concentration in the cerebrospinal fluid of the ape and dog after intravenous administration, and relation to its convulsant effect].
Topics: Administration, Intravenous; Animals; Convulsants; Dogs; Isomerism; Isoniazid; Niacin; Nicotinic Aci | 1953 |
[Latency period of the sensitivity to the convulsive effect of isoniazid in the dog and ape after intravenous administration].
Topics: Administration, Intravenous; Animals; Dogs; Isomerism; Isoniazid; Niacin; Nicotinic Acids; Seizures | 1953 |
[Mechanism of convulsive action of isonicotinic acid hydrazide].
Topics: Isomerism; Isoniazid; Niacin; Nicotinic Acids; Seizures | 1953 |
[Acute toxicity of isoniazid after intraspinal administration in monkey and in dog].
Topics: Animals; Dogs; Haplorhini; Isomerism; Isoniazid; Niacin; Nicotinic Acids; Seizures | 1953 |
[Experimental and clinical study of acute toxicology of isonicotinic acid hydrazide].
Topics: Barbiturates; Humans; Isoniazid; Niacin; Nicotinic Acids; Seizures | 1954 |
[Neurological complications of isoniazid therapy of tuberculosis].
Topics: Isoniazid; Nervous System; Neuritis; Niacin; Nicotinic Acids; Seizures; Tuberculosis | 1954 |
[Antagonistic effect of Indian hemp on toxic-convulsant syndrome due to isonicotinic acid hydrazide].
Topics: Apocynum; Cannabis; Convulsants; Hibiscus; Hostility; Isoniazid; Niacin; Nicotinic Acids; Seizures | 1954 |
Psychiatric and neurological side-effects of isoniazid and iproniazid.
Topics: Disease; Iproniazid; Isoniazid; Mental Disorders; Niacin; Nicotinic Acids; Psychotic Disorders; Seiz | 1954 |
[Two cases of toxic manifestations in the treatment of pulmonary tuberculosis with isonicotinic acid hydrazide].
Topics: Isoniazid; Kidney; Niacin; Nicotinic Acids; Seizures; Tuberculosis; Tuberculosis, Pulmonary | 1954 |
Convulsive reaction in a two-year-old child following the accidental ingestion of an overdosage of isoniazid.
Topics: Barbiturates; Child; Drug Overdose; Humans; Infant; Isoniazid; Niacin; Nicotinic Acids; Poisoning; S | 1956 |
Antagonistic action of paraldehyde toward convulsions produced by isonicotylhydrazide.
Topics: Isoniazid; Paraldehyde; Seizures | 1957 |
[Convulsive action of isoniazid (Apropos of 4 cases)].
Topics: Humans; Isoniazid; Seizures | 1960 |
Experimental analysis of the central effect of convulsive hydrazides.
Topics: Anti-Bacterial Agents; Isoniazid; Seizures; Thiosemicarbazones | 1961 |
[Anti-toxic action of glutamic acid, of vitamin B6 and of a combination of glutamic acid and vitamin B6 against the convulsant action and the lethal effects induced by isonicotinic acid hydrazide (INH) in the rat].
Topics: Animals; Convulsants; Glutamates; Glutamic Acid; Isoniazid; Rats; Seizures; Vitamin B 6 | 1959 |
[Protection of rats against isoniazid-induced convulsions by the potassium and magnesium salts of DL-aspartic acid].
Topics: Animals; Aspartic Acid; Isoniazid; Magnesium; Potassium; Rats; Salts; Seizures | 1959 |
Prevention of the convulsivant and lethal effects of isonicotinic acid hydrazide by pyruvic acid.
Topics: Biomedical Research; Convulsants; Isoniazid; Pyruvates; Pyruvic Acid; Seizures | 1961 |
[Experimental convulsions caused by isoniazid and their therapeutic control, also isoniazidrelated changes in the EEG in children].
Topics: Barbiturates; Child; Electroencephalography; Humans; Infant; Isoniazid; Muscle Relaxants, Central; S | 1962 |
[Electroencephalographic aspects of 2 convulsive seizures induced by hydrazines in the mouse].
Topics: Animals; Electroencephalography; Humans; Hydrazines; Isoniazid; Mice; Niacin; Nicotinic Acids; Seizu | 1963 |
[ACUTE ISONIAZID POISONING WITH PERMANENT CEREBRAL DAMAGE].
Topics: Atrophy; Brain Damage, Chronic; Cerebral Cortex; Child; Coma; Exchange Transfusion, Whole Blood; Int | 1963 |
ACUTE POISONING FROM OVERDOSE OF ISONIAZID; A CASE REPORT.
Topics: Black People; Drug Overdose; Humans; Infant; Isoniazid; Pyridoxine; Seizures; Toxicology | 1963 |
IATROGENIC NEUROLOGICAL DISEASES. DRUG-INDUCED NEUROLOGICAL DISORDERS.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antihypertensive Agents | 1964 |
[ACCIDENTAL INH POISONING IN A 2-YEAR-OLD GIRL].
Topics: Drug-Related Side Effects and Adverse Reactions; Infant; Isoniazid; Phenobarbital; Seizures; Toxicol | 1964 |
THE SEQUELAE OF TUBERCULOUS MENINGITIS.
Topics: Adolescent; Aminosalicylic Acid; Aminosalicylic Acids; Child; Child Behavior Disorders; Cortisone; D | 1964 |
[POTENTIATION BY THEOPHYLLINE AND CAFFEINE OF THE CONVULSANT EFFECTS AND TOXICITY OF ISONIAZID].
Topics: Caffeine; Convulsants; Isoniazid; Pharmacology; Rats; Research; Seizures; Theophylline; Toxicology | 1964 |
NEUROPHYSIOLOGICAL AND NEUROCHEMICAL STUDIES WITH THE ISONICOTINOYLHYDRAZONE OF PYRIDOXAL 5-PHOSPHATE.
Topics: Aminobutyrates; Brain; Brain Chemistry; Carboxy-Lyases; Cats; Cerebellum; Electrophysiology; Frontal | 1964 |
ISONIAZID-INDUCED ENCEPHALOPATHY.
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Brain Diseases; Diagnosis, Differential; Drug Therapy; Is | 1965 |
GRAND MAL SEIZURES FOLLOWING OVERDOSE OF ISONIAZID. A REPORT OF FOUR CASES.
Topics: Adolescent; Drug Therapy; Electroencephalography; Epilepsy; Epilepsy, Tonic-Clonic; Isoniazid; Liver | 1965 |
CORRELATION BETWEEN CONVULSIVE ACTION AND METABOLISM OF ISONIAZID.
Topics: Autoradiography; Brain Chemistry; Carbon Isotopes; Cats; Central Nervous System; Chromatography; Int | 1964 |
U. S. VETERANS ADMINISTRATION-ARMED FORCES COOPERATIVE STUDY ON THE CHEMOTHERAPY OF TUBERCULOSIS.13. TUBERCULOUS MENINGITIS IN ADULTS, WITH SPECIAL REFERENCE TO SURVIVAL, NEUROLOGIC RESIDUALS, AND WORK STATUS.
Topics: Adult; Antitubercular Agents; Black People; Brain; Brain Damage, Chronic; Drug Therapy; Hemiplegia; | 1965 |
[ON A CASE OF ACUTE ISONIAZID INTOXICATION. GRAND MAL EPILEPSY WITH SEVERE METABOLIC ACIDOSIS].
Topics: Acidosis; Epilepsy; Epilepsy, Tonic-Clonic; Isoniazid; Seizures; Toxicology | 1965 |
THE ANTICONVULSANT ACTIVITY OF HYDROXYLAMINE.
Topics: Anticonvulsants; Electric Stimulation; Electroshock; Hydroxylamine; Hydroxylamines; Isoniazid; Morta | 1965 |
ISONIAZID-INDUCED ENCEPHALOPATHY.
Topics: Brain Diseases; Drug Therapy; Epilepsy; Epilepsy, Tonic-Clonic; Isoniazid; Peripheral Nervous System | 1965 |
[Isonicotinic acid hydrazide in the cerebrospinal fluid; pharmacological and toxicological research on monkeys and dogs].
Topics: Animals; Cerebrospinal Fluid; Dogs; Haplorhini; Isomerism; Isoniazid; Niacin; Nicotinic Acids; Resea | 1954 |
[Protective effect of potassium and magnesium salts of DL-aspartic acid against convulsions caused by isoniazid and ammonium chloride in the rat].
Topics: Ammonium Chloride; Animals; Aspartic Acid; Isoniazid; Magnesium; Potassium; Rats; Salts; Seizures | 1959 |
Effects of pyridoxine, gamma-aminobutyric acid and gamma-amino-beta-hydroxybutyric acid on the convulsions of dogs caused by toxopyrimidine or isonicotinic acid hydrazide.
Topics: Amino Acids; Animals; Antifibrinolytic Agents; Dogs; gamma-Aminobutyric Acid; Isoniazid; Pyridoxine; | 1962 |
Effect of isoniazid on the pharmacodynamics of cefazolin-induced seizures in rats.
Topics: Animals; Anti-Bacterial Agents; Brain; Cefazolin; Drug Synergism; Isoniazid; Male; Pyridoxine; Rats; | 2005 |
Persisting dementia after isoniazid overdose.
Topics: Adult; Antitubercular Agents; Dementia; Drug Overdose; Humans; Isoniazid; Male; Neurologic Examinati | 2005 |
Low tolerance and dependence liabilities of etizolam: molecular, functional, and pharmacological correlates.
Topics: Animals; Animals, Newborn; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cul | 2005 |
Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication.
Topics: Acidosis; Acute Disease; Adolescent; Anticonvulsants; Antitubercular Agents; Charcoal; Child; Coma; | 2005 |
Nefopam is more potent than carbamazepine for neuroprotection against veratridine in vitro and has anticonvulsant properties against both electrical and chemical stimulation.
Topics: Analgesics, Non-Narcotic; Animals; Anticonvulsants; Antitubercular Agents; Calcium Channels, L-Type; | 2007 |
[Isoniazid intoxication].
Topics: Acidosis; Anticonvulsants; Antidotes; Antitubercular Agents; Diazepam; Female; Humans; Infusions, In | 2007 |
Isoniazid seizures in the developing rat and the content of pyridoxal 5-phosphate in the brain.
Topics: Animals; Animals, Newborn; Brain; Brain Chemistry; Fluorometry; Isoniazid; Pyridoxal Phosphate; Rats | 1967 |
Neuropathologic effects and comparative toxicity for dogs of isonicotinic acid hydrazide and its methanosulfonate derivative.
Topics: Animals; Brain; Cerebral Cortex; Dogs; Female; Isoniazid; Liver; Male; Myelin Sheath; Organ Size; Se | 1967 |
[Activation of the acetylation in vivo of sulfamide by DL-acetylcarnitine].
Topics: Acetates; Animals; Carbon Tetrachloride Poisoning; Carnitine; Chemical and Drug Induced Liver Injury | 1967 |
[Acute intoxication with isonicotinic acid hydrazide (diagnostic difficulties)].
Topics: Adolescent; Diagnosis, Differential; Humans; Isoniazid; Male; Seizures | 1967 |
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Antagonists; gamma-Amin | 1980 |
[Acute isoniazid poisoning in a young child (author's transl)].
Topics: Humans; IgA Vasculitis; Infant; Isoniazid; Male; Pyridoxine; Renal Dialysis; Seizures | 1981 |
Are benzodiazepine recognition sites functional entities for the action of endogenous effector(s) or merely drug receptor(s)?
Topics: Animals; Benzodiazepinones; Brain; Flumazenil; gamma-Aminobutyric Acid; Humans; Isoniazid; Neurotran | 1983 |
Halothane effect on cGMP and control of motor activity in mouse cerebellum.
Topics: Animals; Cerebellum; Cyclic GMP; Halothane; Isoniazid; Male; Mice; Motor Activity; Picrotoxin; Seizu | 1981 |
Anticonvulsant effects of caerulein, cholecystokinin octapeptide (CCK-8) and diazepam against seizures produced in mice by harman, thiosemicarbazide and isoniazid.
Topics: Animals; Anticonvulsants; Ceruletide; Cholecystokinin; Diazepam; Haloperidol; Harmine; Isoniazid; Ma | 1981 |
Specific proconvulsant action of an imidazobenzodiazepine (RO 15-1788) on isoniazid convulsions.
Topics: Animals; Benzodiazepinones; Brain; Convulsants; Drug Synergism; Flumazenil; gamma-Aminobutyric Acid; | 1982 |
Deuterated halothane--anesthetic potency, anticonvulsant activity, and effect on cerebellar cyclic guanosine 3',5'-monophosphate.
Topics: Animals; Cerebellum; Cyclic GMP; Deuterium; Drug Evaluation, Preclinical; Gas Chromatography-Mass Sp | 1984 |
Increase in the Bmax of gamma-aminobutyric acid-A recognition sites in brain regions of mice receiving diazepam.
Topics: Animals; Brain; Cerebellum; Diazepam; gamma-Aminobutyric Acid; Isoniazid; Kinetics; Mice; Motor Acti | 1984 |
Evidence for an involvement of GABA receptors in the mediation of the proconvulsant action of ethyl-beta-carboline-3-carboxylate.
Topics: Animals; Binding Sites; Carbolines; Cerebral Cortex; Drug Synergism; gamma-Aminobutyric Acid; Hippoc | 1984 |
Synergistic effect of phosphatidylserine with gamma-aminobutyric acid in antagonizing the isoniazid-induced convulsions in mice.
Topics: Animals; Drug Synergism; Drug Therapy, Combination; gamma-Aminobutyric Acid; Isoniazid; Liposomes; L | 1984 |
Anticonvulsant activity of the nipecotic acid ester, (+/-)-m-nitrophenyl-3-piperidinecarboxylate.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Nipecotic Acids; Pe | 1984 |
Isoniazid overdose treated with high-dose pyridoxine.
Topics: Acidosis; Adolescent; Adult; Female; Humans; Isoniazid; Male; Pyridoxine; Seizures | 1983 |
Morphine potentiates seizures induced by GABA antagonists and attenuates seizures induced by electroshock in the rat.
Topics: Animals; Bicuculline; Drug Synergism; Electroshock; GABA Antagonists; Isoniazid; Male; Morphine; Nal | 1983 |
Isoniazid induced seizures and cerebral cortical and cerebellar energy metabolism.
Topics: Adenosine Triphosphate; Animals; Cerebellar Cortex; Cerebral Cortex; Clonazepam; Energy Metabolism; | 1982 |
Anticonvulsant activity of the glial-selective GABA uptake inhibitor, THPO.
Topics: 4-Aminobutyrate Transaminase; Animals; Animals, Newborn; Anticonvulsants; Chickens; Cyclohexanecarbo | 1983 |
[Acute isoniazid poisoning].
Topics: Acidosis; Child; Coma; Female; Humans; Isoniazid; Seizures | 1983 |
Anticonvulsant effects of PGE2 on electrical, chemical and photomyoclonic animal models of epilepsy.
Topics: Animals; Anticonvulsants; Brain; Dinoprostone; Disease Models, Animal; Electric Stimulation; gamma-A | 1981 |
Acute isoniazid poisoning in childhood.
Topics: Adolescent; Child, Preschool; Coma; Female; Humans; Infant; Isoniazid; Male; Paraldehyde; Pyridoxine | 1980 |
Soman-induced convulsions: significance of changes in levels of blood electrolytes, gases, glucose, and insulin.
Topics: Animals; Blood Glucose; Electrolytes; Insulin; Isoniazid; Male; Organophosphorus Compounds; Rats; Se | 1980 |
Carbamazepine-isoniazid interaction.
Topics: Adolescent; Carbamazepine; Drug Interactions; Female; Humans; Isoniazid; Seizures | 1982 |
Effect of trimethyltin on chemically-induced seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Isoniazid; Male; Mice; Pentylenetetrazole; Seizures; Strychni | 1982 |
Isoniazid poisoning in a dog.
Topics: Animals; Diazepam; Dog Diseases; Dogs; Fluid Therapy; Isoniazid; Male; Pentobarbital; Seizures | 1982 |
Postictal pleocytosis.
Topics: Adult; Blood-Brain Barrier; Cerebrospinal Fluid; Female; Humans; Isoniazid; Male; Middle Aged; Seizu | 1981 |
Diphenylhydantoin potentiates the protective effect of diazepam against pentylenetetrazol but not against bicuculline and isoniazid-induced seizures in mice.
Topics: Animals; Bicuculline; Diazepam; Drug Synergism; Isoniazid; Male; Mice; Pentylenetetrazole; Phenytoin | 1981 |
Potentiation of hydralazine-induced convulsion by isoniazid in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Hydralazine; Isoniazid; Male; Rats; Seizu | 1981 |
Single high-dose pyridoxine treatment for isoniazid overdose.
Topics: Acidosis; Adolescent; Adult; Bicarbonates; Coma; Female; Humans; Isoniazid; Male; Pyridoxine; Seizur | 1981 |
Effect of gamma-vinyl GABA on bicuculline-induced seizures.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Anticonvulsants; Bicuculline; Brain Chemistry | 1981 |
Isoniazid toxicity. Pyridoxine controlled seizures in a dialysis patient.
Topics: Female; Humans; Isoniazid; Middle Aged; Pyridoxine; Renal Dialysis; Seizures; Tuberculosis, Pulmonar | 1981 |
Acute isoniazid poisoning in children.
Topics: Acute Disease; Child, Preschool; Coma; Diazepam; Female; Humans; Isoniazid; Pyridoxine; Seizures | 1981 |
Isoniazid-associated rhabdomyolysis.
Topics: Adolescent; Charcoal; Chemical and Drug Induced Liver Injury; Diazepam; Female; Humans; Isoniazid; P | 1995 |
Acute isoniazid neurotoxicity in an urban hospital.
Topics: Acute Disease; Adolescent; Child; Female; Humans; Infant, Newborn; Infusions, Intravenous; Isoniazid | 1995 |
INH-induced neurotoxicity.
Topics: Acidosis; Adult; Brain; Drug Overdose; Humans; Isoniazid; Pyridoxine; Seizures | 1994 |
Low-level hyperbaric antagonism of ethanol's anticonvulsant property in C57BL/6J mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsies, Myoclonic; Ethanol; Hyperbar | 1994 |
Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Drug | 1993 |
Effect of isonicotinic acid hydrazide on extracellular amino acids and convulsions in the rat: reversal of neurochemical and behavioural deficits by sodium valproate.
Topics: Amino Acids; Animals; Aspartic Acid; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Gl | 1994 |
Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives.
Topics: Aggression; Allosteric Regulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; | 1993 |
Imidazenil, a new partial agonist of benzodiazepine receptors, reverses the inhibitory action of isoniazid and stress on gamma-aminobutyric acidA receptor function.
Topics: Animals; Benzodiazepines; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds | 1994 |
Seizures associated with poisoning and drug overdose.
Topics: Adolescent; Adult; Age Factors; Aged; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Caus | 1993 |
Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.
Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Brain; Bridged Bicyclo Compounds; Bridged Bic | 1993 |
[Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose].
Topics: Acidosis; Adolescent; Drug Overdose; Female; Humans; Infusions, Intravenous; Isoniazid; Pyridoxine; | 1993 |
Chronic ethanol intoxication induces differential effects on GABAA and NMDA receptor function in the rat brain.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo | 1993 |
Reversible seizures and mental status changes in a dialysis patient on isoniazid preventive therapy.
Topics: Aged; Confusion; Female; Humans; Isoniazid; Peritoneal Dialysis, Continuous Ambulatory; Pyridoxine; | 1993 |
Antagonism of isoniazid-induced convulsions by abecarnil in mice tolerant to diazepam.
Topics: Animals; Anticonvulsants; Benzodiazepines; Carbolines; Convulsants; Diazepam; Dose-Response Relation | 1995 |
Acute isoniazid neurotoxicity in an urban hospital.
Topics: Acute Disease; Antitubercular Agents; Bosnia and Herzegovina; Child; Electroencephalography; Hospita | 1996 |
Acute isoniazid intoxication: a case report.
Topics: Acidosis; Acute Disease; Adult; Antitubercular Agents; Coma; Female; Humans; Isoniazid; Seizures | 1996 |
Functional correlation between allopregnanolone and [35S]-TBPS binding in the brain of rats exposed to isoniazid, pentylenetetrazol or stress.
Topics: Animals; Antitubercular Agents; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsant | 1996 |
Chronic ethanol intoxication enhances [3H]CCPA binding and does not reduce A1 adenosine receptor function in rat cerebellum.
Topics: Adenosine; Alcoholism; Animals; Cerebellar Cortex; Cerebellum; Dose-Response Relationship, Drug; Eth | 1996 |
Synthesis and anticonvulsant activity of some 1,2,3,3a-tetrahydropyrrolo[2,1-b]-benzothiazol-, -thiazol- or -oxazol-1-ones in rodents.
Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Isoniazid; Male; Mice; Pyrrolidines; Rats; R | 1996 |
Sarmazenil-precipitated withdrawal: a reliable method for assessing dependence liability of benzodiazepine receptor ligands.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Convulsants; Diazepam; Drug Toleran | 1998 |
Increased abundance of GABAA receptor subunit mRNAs in the brain of Long-Evans Cinnamon rats, an animal model of Wilson's disease.
Topics: Aging; Analysis of Variance; Animals; Disease Models, Animal; Hepatolenticular Degeneration; Isoniaz | 1999 |
Seizures induced by theophylline and isoniazid in mice.
Topics: Animals; Antitubercular Agents; Bronchodilator Agents; Dose-Response Relationship, Drug; Female; Iso | 1999 |
Pharmacological studies on synthetic flavonoids: comparison with diazepam.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Diazepam; Discrimination Learning; Escape Reaction | 1999 |
Pyridoxine treatment for seizures induced by theophylline and isoniazid?
Topics: Animals; Drug Interactions; Isoniazid; Mice; Pyridoxine; Seizures; Theophylline | 1999 |
Selective susceptibility to inhibitors of GABA synthesis and antagonists of GABA(A) receptor in rats with genetic absence epilepsy.
Topics: 3-Mercaptopropionic Acid; Animals; Bicuculline; Carbolines; Convulsants; Electroencephalography; Epi | 2000 |
[Acute isoniazid poisoning presenting convulsion and liver dysfunction].
Topics: Acute Disease; Adult; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Ethambutol; Fem | 2001 |
Rhabdomyolysis in isoniazid poisoning.
Topics: Adolescent; Adult; Age Distribution; Child; Child, Preschool; Creatine Kinase; Creatine Kinase, MM F | 2001 |
A 23-year-old with refractory seizures following an isoniazid overdose.
Topics: Adult; Anticonvulsants; Drug Overdose; Follow-Up Studies; Humans; Isoniazid; Male; Recurrence; Risk | 2002 |
A 14-year-old girl with refractory seizures.
Topics: Adolescent; Antitubercular Agents; Drug Overdose; Female; Humans; Isoniazid; Seizures; Self Medicati | 2001 |
Influence of convulsants on rat brain activities of alanine aminotransferase and aspartate aminotransferase.
Topics: 3-Mercaptopropionic Acid; Aging; Alanine Transaminase; Animals; Aspartate Aminotransferases; Brain; | 2001 |
Isoniazid-induced seizures with secondary rhabdomyolysis and associated acute renal failure in a dog.
Topics: Acute Kidney Injury; Animals; Antitubercular Agents; Blood Chemical Analysis; Dog Diseases; Dogs; Fa | 2002 |
Convulsions as the etiology of lactic acidosis in acute isoniazid toxicity in dogs.
Topics: Acidosis; Acute Disease; Animals; Antidotes; Bicarbonates; Carbon Dioxide; Dogs; Hydrogen-Ion Concen | 1979 |
Metabolite levels in brain following experimental seizures: the effects of isoniazid and sodium valproate in cerebellar and cerebral cortical layers.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Cyclic AMP; Cyclic GMP; gamma-Aminobutyric Acid; Glucos | 1979 |
Anticonvulsant activity of muscimol against seizures induced by impairment of GABA-mediated neurotransmission.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Oxazoles; | 1979 |
Motor patterns of seizures during ontogenesis in rats [proceedings].
Topics: Aminooxyacetic Acid; Animals; Azoles; Injections, Intraperitoneal; Isoniazid; Rats; Seizures | 1979 |
Effects of intracerebroventricular administration of prostaglandins E1 and E2 on chemically induced convulsions in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Injections, Intraventricular; Isoniazid; | 1979 |
Stability of synaptosomal GABA levels and their use in determining the in vivo effects of drugs: convulsant agents.
Topics: Acetates; Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyric Acid; Hydrazines; Isoniazid; Kinet | 1979 |
gamma-Aminobutyric acid in subcellular fractions of mouse brain and its relation to convulsions.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Penicillamine; Seizures; Semicarbazi | 1979 |
Mechanisms underlying modifications in the severity of audiogenic convulsions.
Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Acoustic Sti | 1977 |
Evaluation of diazepam and pyridoxine as antidotes to isoniazid intoxication in rats and dogs.
Topics: Animals; Antidotes; Diazepam; Dogs; Drug Therapy, Combination; Isoniazid; Male; Pyridoxine; Rats; Se | 1978 |
Antiseizure activity of gamma-acetylenic gamma-aminobutyric acid: a catalytic irreversible inhibitor of gamma-aminobutyric acid transaminase.
Topics: 4-Aminobutyrate Transaminase; Aminobutyrates; Animals; Anticonvulsants; Brain Chemistry; Electroshoc | 1977 |
Convulsions induced by hyperbaric oxygen: inhibition by phenobarbital, diazepam and baclofen.
Topics: Aminobutyrates; Animals; Baclofen; Diazepam; Female; gamma-Aminobutyric Acid; Glycine; Hyperbaric Ox | 1977 |
Elevation of central gamma-aminobutyric acid levels by isoniazid in mice and convulsant thresholds.
Topics: Aminobutyrates; Animals; Brain; Brain Chemistry; Electroshock; gamma-Aminobutyric Acid; Glutamate De | 1976 |
3-Isoxazolidone--an inhibitor of GABA metabolism.
Topics: Aminobutyrates; Animals; Brain; Chickens; Depression, Chemical; GABA Antagonists; gamma-Aminobutyric | 1976 |
Preconvulsive changes in brain glucose metabolism following drugs inhibiting glutamate decarboxylase.
Topics: Animals; Blood Glucose; Body Temperature; Brain; Carboxy-Lyases; Glucose; Glutamate Decarboxylase; G | 1976 |
A dual mechanism for the anticonvulsant action of aminooxyacetic acid.
Topics: Acetates; Allyl Compounds; Aminooxyacetic Acid; Animals; Anticonvulsants; Behavior, Animal; Brain Ch | 1976 |
Neonatal pyridoxine responsive convulsions due to isoniazid therapy.
Topics: Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Isoniazid; Male; Pregnancy; Preg | 1976 |
Treatment of acute isoniazid toxicity.
Topics: Acidosis; Adolescent; Adult; Airway Obstruction; Anticonvulsants; Bicarbonates; Coma; Diuresis; Fema | 1975 |
The anticonvulsant action of GABA-elevating agents: a re-evaluation.
Topics: Allyl Compounds; Aminobutyrates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Drug Evaluati | 1975 |
Suicidal ingestion of isoniazid: an uncommon cause of metabolic acidosis and seizures.
Topics: Acidosis; Adolescent; Adult; Bicarbonates; Diazepam; Diuresis; Female; Humans; Infusions, Parenteral | 1976 |
Isoniazid-induced convulsions.
Topics: Adolescent; Adult; Animals; Child, Preschool; Drug Combinations; Female; Humans; Isoniazid; Male; Py | 1976 |
The effect of castrix (2-chloro-4- dimethylamino-6-methylpyrimidine) on the distribution of B6 vitamers in mouse brain.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Isoniazid; Male; Mice; Penicillamine; Pyridoxa | 1976 |
2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR).
Topics: Acetamides; Animals; Bicuculline; Binding, Competitive; Brain; Diazepam Binding Inhibitor; Indoleace | 1992 |
Effects of benzodiazepine receptor ligands with different intrinsic activities on seizures induced by inhibition of GAD.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Glutamate D | 1992 |
Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem.
Topics: Animals; Drug Tolerance; Electroshock; Hypnotics and Sedatives; Injections, Intraperitoneal; Isoniaz | 1992 |
Repeated administration of triiodothyronine enhances the susceptibility of rats to isoniazid- and picrotoxin-induced seizures.
Topics: Animals; Binding Sites; Cerebral Cortex; Flunitrazepam; Hippocampus; Hyperthyroidism; Isoniazid; Mal | 1992 |
Lack of proconvulsant action of GABA depletion in substantia nigra in several seizure models.
Topics: Animals; Bicuculline; Cerebral Cortex; gamma-Aminobutyric Acid; Isoniazid; Kainic Acid; Male; Microi | 1991 |
Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Diazepam; Drug Interactions; Electroshock; Felbamate; GABA-A | 1991 |
Ipecac contraindicated with overdoses of seizure-inducing drugs.
Topics: Contraindications; Humans; Ipecac; Isoniazid; Poisoning; Seizures | 1991 |
Pentylenetetrazol-induced kindling in rats: effect of GABA function inhibitors.
Topics: Animals; Azides; Benzodiazepines; Carbolines; GABA Antagonists; Isoniazid; Kindling, Neurologic; Mal | 1991 |
Ontogenetic development of isonicotinehydrazide-induced seizures in rats.
Topics: Aging; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Isoniazid; Male; Motor Activ | 1991 |
Action of thiopental in isoniazid-induced seizures: GABA augmentation or electroencephalographic suppression?
Topics: Electroencephalography; gamma-Aminobutyric Acid; Humans; Isoniazid; Seizures; Thiopental | 1991 |
Foot-shock stress enhances the increase of [35S]TBPS binding in the rat cerebral cortex and the convulsions induced by isoniazid.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convul | 1991 |
Low-level hyperbaric heliox does not affect drug-induced seizure latency in mice.
Topics: Allylglycine; Animals; Atmospheric Pressure; Convulsants; Helium; Hyperbaric Oxygenation; Isoniazid; | 1991 |
Treatment of refractory seizures in massive isoniazid overdose.
Topics: Adult; Drug Overdose; Humans; Isoniazid; Male; Seizures; Suicide, Attempted | 1990 |
Isoniazid toxicity presenting as seizures and metabolic acidosis.
Topics: Acidosis; Adolescent; Humans; Infusions, Intravenous; Isoniazid; Male; Pyridoxine; Seizures | 1990 |
Accidental poisoning with isoniazid and rifampicin in an infant: role of peritoneal dialysis.
Topics: Accidents, Home; Female; Humans; Infant; Isoniazid; Peritoneal Dialysis; Rifampin; Seizures | 1989 |
Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Isoniazid; Isoxazoles; Male; Nervous System; Neur | 1989 |
Complete recovery from severe metabolic acidosis associated with isoniazid poisoning in a young boy.
Topics: Acidosis, Lactic; Adolescent; Combined Modality Therapy; Emergencies; Humans; Hydrogen-Ion Concentra | 1989 |
Metabolism of 3-(p-chlorophenyl)pyrrolidine. Structural effects in conversion of a prototype gamma-aminobutyric acid prodrug to lactam and gamma-aminobutyric acid type metabolites.
Topics: Amino Acids; Animals; Baclofen; Brain; Chemical Phenomena; Chemistry; Chromatography, High Pressure | 1989 |
Synergistic anticonvulsant action of diazepam & clonazepam with amino-oxyacetic acid against isoniazid-induced convulsions in rats.
Topics: Acetates; Aminooxyacetic Acid; Animals; Clonazepam; Diazepam; Drug Therapy, Combination; Isoniazid; | 1989 |
Isonicotinic hydrazide causes seizures in scrapie-infected hamsters with shorter latency than in control animals: a possible GABAergic defect.
Topics: Animals; Brain; Brain Chemistry; Cricetinae; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic A | 1985 |
Anti-convulsant effects by reduced glutathione and related aminoacids in rats treated with isoniazid.
Topics: Animals; Brain Chemistry; Cysteine; Drug Interactions; gamma-Aminobutyric Acid; Glutamates; Glutamic | 1988 |
Behavioural and biochemical evidence for a long-lasting decrease in GABAergic function elicited by chronic administration of FG 7142.
Topics: Animals; Avoidance Learning; Behavior, Animal; Brain Chemistry; Carbolines; Cerebellum; Cerebral Cor | 1986 |
Microgram doses of diazepam do not induce proconvulsant or proconflict effects in rodents.
Topics: Animals; Bicuculline; Conditioning, Operant; Diazepam; Isoniazid; Mice; Pentylenetetrazole; Picrotox | 1987 |
Treatment of a potentially lethal dose isoniazid ingestion.
Topics: Acidosis; Blood Gas Analysis; Child; Coma; Emergencies; Humans; Isoniazid; Male; Oliguria; Renal Dia | 1988 |
Gamma-vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice.
Topics: 4-Aminobutyrate Transaminase; Amino Acids; Aminocaproates; Animals; Anticonvulsants; Brain; gamma-Am | 1988 |
Acute isoniazid toxicity--report of 2 cases and review of literature.
Topics: Acute Disease; Adult; Coma; Humans; Isoniazid; Male; Seizures; Suicide | 1987 |
Isoniazid overdose: pharmacokinetics and effects of oral charcoal in treatment.
Topics: Adolescent; Charcoal; Electroencephalography; Female; Humans; Isoniazid; Male; Renal Dialysis; Seizu | 1987 |
Susceptibility to seizures produced by pilocarpine in rats after microinjection of isoniazid or gamma-vinyl-GABA into the substantia nigra.
Topics: Aminocaproates; Animals; Isoniazid; Male; Microinjections; Pilocarpine; Rats; Rats, Inbred Strains; | 1986 |
Toxic overdose of isoniazid, rifampicin and ethambutol.
Topics: Acidosis; Adult; Alanine Transaminase; Aspartate Aminotransferases; Ethambutol; Female; Humans; Ison | 1986 |
Isoniazid overdose in the Cambodian population of Olmsted County, Minnesota.
Topics: Acidosis; Adolescent; Adult; Asian; Cambodia; Female; Humans; Isoniazid; Life Change Events; Male; M | 1986 |
Isoniazid-induced convulsions in rats: effects of Ro 15-1788 and beta-CCE.
Topics: Animals; Benzodiazepinones; Carbolines; Dose-Response Relationship, Drug; Drug Interactions; Flumaze | 1985 |
The specific protective effect of diazepam and valproate against isoniazid-induced seizures is not correlated with increased GABA levels.
Topics: Amino Acids; Animals; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoniazid | 1985 |
Pyridoxine deficiency in children treated with isoniazid.
Topics: Child; Child Nutritional Physiological Phenomena; Child, Preschool; Electromyography; Female; Humans | 1985 |
Photic and drug-induced epilepsy in the baboon (Papio papio): the effects of isoniazid, thiosemicarbazide, pyridoxine and amino-oxyacetic acid.
Topics: Acetates; Aminobutyrates; Animals; Behavior, Animal; Cerebral Cortex; Electroencephalography; Haplor | 1970 |
Drug-induced convulsions. Report from Boston Collaborative Drug Surveillance Program.
Topics: Chlorpromazine; Ephedrine; Female; Humans; Hypoglycemic Agents; Injections, Intravenous; Insulin; Is | 1972 |
Possible role of gamma-aminobutyric acid in paraoxon-induced convulsions.
Topics: Aminobutyrates; Animals; Brain Chemistry; Insecticides; Isoniazid; Male; Paraoxon; Phenobarbital; Ra | 1972 |
Development of an expression which relates the excitable state of the brain to the level of GAD activity and GABA content, with particular reference to the action of hydrazine and its derivatives.
Topics: Aminobutyrates; Animals; Brain; Carboxy-Lyases; Chickens; Dose-Response Relationship, Drug; Fasting; | 1974 |
Effect of barbiturates and isoniazid on cerebral hemisphere gamma-aminobutyric acid content in pp' DDT treated mice.
Topics: Aminobutyrates; Animals; Anticonvulsants; Barbiturates; Behavior, Animal; Brain Chemistry; DDT; Drug | 1974 |
Acute intoxications and convulsions. An EEG study of three very different products: rimifon, chloralose and methaldehyde.
Topics: Acute Disease; Aldehydes; Cerebral Cortex; Chloralose; Electroencephalography; Humans; Isoniazid; Se | 1968 |
[Neuropsychiatric incidences in antitubercular treatment consisting of isoniazid or isoniazid and ethionamide (8 cases)].
Topics: Acidosis; Adult; Alcoholism; Ammonia; Avitaminosis; Carboxy-Lyases; Chromatography, Paper; Chromatog | 1969 |
Effect of long-term administration of ACTH and adrenocortical hormones on the course of hydrazide convulsions.
Topics: Adrenocorticotropic Hormone; Animals; Desoxycorticosterone; Drug Synergism; Female; Hydrocortisone; | 1967 |
The effect of isoniazid and some anticonvulsant drugs on the gamma-aminobutyric acid content of mouse brain in insulin hypoglycaemia.
Topics: Aminobutyrates; Animals; Barbiturates; Brain; Brain Chemistry; Cerebral Cortex; Hypoglycemia; Insuli | 1970 |
The effect of hypoxia on isonicotinic acid hydrazide-induced seizures in chicks during ontogenesis.
Topics: Age Factors; Aminobutyrates; Animals; Brain; Brain Chemistry; Chickens; Hypoxia; Isoniazid; Male; Se | 1971 |
A correlation between changes in GABA metabolism and isonicotinic acid hydrazide-induced seizures.
Topics: Aminobutyrates; Animals; Brain; Carbon Isotopes; Carboxy-Lyases; Chickens; Isoniazid; Seizures | 1972 |
[The hazards of intravenous infusions of tubazid].
Topics: Adult; Female; Humans; Injections, Intravenous; Isoniazid; Seizures; Tuberculosis, Pulmonary | 1972 |
The role of GABA metabolism in the convulsant and anticonvulsant actions of aminooxyacetic acid.
Topics: Aminobutyrates; Animals; Anticonvulsants; Brain; Carbon Isotopes; Carboxy-Lyases; Dose-Response Rela | 1973 |
Isonicotinic acid hydrazide-induced changes in the metabolism of gamma-aminobutyric acid in the brain of four species.
Topics: Aminobutyrates; Animals; Brain; Brain Chemistry; Carbon Isotopes; Carboxy-Lyases; Chickens; Glucose; | 1973 |
The anticonvulsant properties of isonicotinic acid hydrazide and associated changes in gamma-aminobutyric acid metabolism.
Topics: Aminobutyrates; Animals; Anticonvulsants; Carbon Radioisotopes; Carboxy-Lyases; Chickens; Glutamates | 1973 |
Isoniazid toxicity. Reversal with pyridoxine.
Topics: Adolescent; Diazepam; Humans; Hyperglycemia; Hypothermia; Isoniazid; Lactates; Male; Pyridoxine; Sei | 1974 |
Isoniazid induced life-threatening neurologic reaction in an allergic individual.
Topics: Adult; Anaphylaxis; Asthma; Bronchitis; Central Nervous System Diseases; Chemical and Drug Induced L | 1970 |
The effect on GABA metabolism in brain of isonicotinic acid hydrazide and pyridoxine as a fuction of time after administration.
Topics: Aminobutyrates; Animals; Brain; Brain Chemistry; Carbon Isotopes; Carboxy-Lyases; Chickens; Enzyme A | 1972 |
Photosensitive epilepsy of the baboon Papio papio.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy; Isoniazid; Light; Lysergic Acid D | 1972 |
Death following massive ingestion of isoniazid.
Topics: Acidosis; Adolescent; Anticonvulsants; Coma; Fever; Gastric Lavage; Humans; Intubation, Intratrachea | 1969 |
[Pharmacology of hydrazinocarbonic acids, hydrazinopeptides and various hydrazine derivatives. IV. Anticonvulsive effects of aliphatic hydrazinocarbonic acids, peptides containing these heteroconstituents and of other hydrazine derivatives].
Topics: Acetates; Aminobutyrates; Animals; Anticonvulsants; Body Temperature; Electroshock; Hydrazines; Inje | 1969 |
[Grave epileptiform reaction to tubazid].
Topics: Adult; Female; Humans; Isoniazid; Seizures | 1969 |
[Neuropsychiatric repercussions of antitubercular treatment with isoniazid, or isoniazid and ethionamide (apropos of 8 cases)].
Topics: Adult; Coma; Ethionamide; Female; Humans; Isoniazid; Male; Mental Disorders; Middle Aged; Neurologic | 1969 |
Isoniazid self-poisoning.
Topics: Acidosis; Adolescent; Adult; Female; Humans; Isoniazid; Male; Peritoneal Dialysis; Poisoning; Renal | 1970 |
[Influence of isoniazid (INH) on the central nervous system and the antagonism between isoniazid and pyridoxine as well as pantothenic acid and coumarin from Melilotus officinalis in rats].
Topics: Animals; Central Nervous System; Conditioning, Classical; Coumarins; Disease Models, Animal; Isoniaz | 1970 |
[Effect of coumarin from Melilotus officinalis on the convulsion threshold of the central nervous system in rats and guinea pigs].
Topics: Animals; Coumarins; Disease Models, Animal; Guinea Pigs; Isoniazid; Pentylenetetrazole; Plant Extrac | 1970 |
The comparative effects of various hydrazides on -aminobutyric acid and its metabolism.
Topics: Aminobutyrates; Animals; Brain; Brain Chemistry; Carboxy-Lyases; Chickens; Hydrazines; Isoniazid; Re | 1971 |
[Dialysis in isoniazid poisoning].
Topics: Adolescent; Apnea; Female; Humans; Intubation, Intratracheal; Isoniazid; Middle Aged; Peritoneal Dia | 1971 |
Encephalopathy following accidental isoniazid poisoning.
Topics: Brain Chemistry; Brain Diseases; Child, Preschool; Humans; Isoniazid; Male; Phenobarbital; Pyridoxin | 1971 |
[On acute isoniazid poisoning on the basis of 2 successfully treated cases].
Topics: Adult; Alcoholism; Blood Transfusion; Brain; Brain Edema; Gastric Lavage; Glucose; Glutamates; Human | 1967 |
[Acute poisonings and convulsive crises. Electroencephalographic study of 3 very different products: Rimifon, chloralose, metaldehyde].
Topics: Acetaldehyde; Brain; Chloralose; Coma; Electroencephalography; Humans; Isoniazid; Poisoning; Seizure | 1967 |
Seizures in experimental porphyria.
Topics: Amides; Animals; Female; Isoniazid; Porphyrias; Porphyrins; Pyridoxal Phosphate; Pyridoxine; Rats; S | 1968 |
[Acute isoniazid poisoning. (Preliminary note on the study of 231 cases with poisoning)].
Topics: Adolescent; Adult; Amnesia; Coma; Female; Gastrointestinal Diseases; Hallucinations; Humans; Hypergl | 1968 |
[Convulsive crises and coma revealing acute isoniazid poisoning].
Topics: Adult; Coma; Female; Humans; Isoniazid; Seizures; Tuberculosis, Pulmonary | 1968 |
[Contribution on the INH poisoning].
Topics: Aged; Hexobarbital; Humans; Infusions, Parenteral; Isoniazid; Male; Medication Errors; Middle Aged; | 1968 |
[Chronic neuritis and convulsive syndrome following the administration of isoniazid].
Topics: Adolescent; Female; Humans; Isoniazid; Optic Neuritis; Seizures; Tuberculosis, Pulmonary | 1965 |
[Acute isoniazid poisoning. Points of onset in the macro-organism, symptoms and measures of treatment].
Topics: Amino Acids; Ammonia; Animals; Barbiturates; Biochemical Phenomena; Biochemistry; Blood; Hexobarbita | 1965 |