Compounds > isoniazid
Page last updated: 2024-10-29

isoniazid and Optic Neuritis

isoniazid has been researched along with Optic Neuritis in 37 studies

Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).

Optic Neuritis: Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis).

Research Excerpts

ExcerptRelevanceReference
"To report a case of optic neuritis associated with concurrent etanercept and isoniazid therapy."7.73Optic neuritis with concurrent etanercept and isoniazid therapy. ( Antón-Torres, R; Borrás-Blasco, J; González-Ferrandez, JA; Navarro-Ruiz, A; Noguera-Pons, R; Romero-Crespo, I, 2005)
"To report a case of optic neuritis associated with concurrent etanercept and isoniazid therapy."3.73Optic neuritis with concurrent etanercept and isoniazid therapy. ( Antón-Torres, R; Borrás-Blasco, J; González-Ferrandez, JA; Navarro-Ruiz, A; Noguera-Pons, R; Romero-Crespo, I, 2005)
" The authors report here a case where despite an adjusted initial dose there was a decrease in the rate of acetylation during treatment with INH-rifampicin and ethambutol, without hepatic involvement but accompanied by retrobulbar optic neuritis."3.65[Modification during treatment of the rate of acetylation of isoniazide clinically or biologically detectable hepatic damage (author's transl)]. ( Albengres, E; Breau, JL; Chrétien, J; Hirsch, A; Houin, G; Saltiel, JC; Tillement, JP, 1977)
" However, their neurotoxicity could cause adverse effect and the patients with end-stage renal disease are especially vulnerable due to the reduction in renal drug clearance."1.48Ethambutol and isoniazid induced severe neurotoxicity in a patient undergoing continuous ambulatory peritoneal dialysis. ( Chen, Y; Li, H; Peng, H; Si, M, 2018)
" Many of these adverse side effects can be greatly reduced or prevented with close monitoring of patients."1.31Ocular toxicity of systemic medications: a case series. ( To, TQ; Townsend, JC, 2000)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199026 (70.27)18.7374
1990's2 (5.41)18.2507
2000's4 (10.81)29.6817
2010's5 (13.51)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Si, M1
Li, H1
Chen, Y1
Peng, H1
Rana, P1
Roy, V1
Ahmad, J1
Yates, WB1
Nothling, S1
Lawlor, M1
Laktaoui, A1
Naoumi, A1
Reda, K1
Kriet, M1
Elouarsani, A1
Khayati, A1
Elharradi, A1
Rouimi, A1
Douhal, A1
Mounahc, J1
Houmadi, A1
Kulkarni, HS1
Keskar, VS1
Bavdekar, SB1
Gabhale, Y1
Zaki, SA1
KEEPING, JA1
SEARLE, CW1
KASS, I1
MANDEL, W1
COHEN, H1
DRESSLER, SH1
LUSZCZEWSKA-TOMASZEWSKA, D1
KOLOSOWSKA, J1
MERGEL-MADEY, B1
HENRY, C1
LEHUNSEC, J1
FONTAN, P1
Noguera-Pons, R1
Borrás-Blasco, J1
Romero-Crespo, I1
Antón-Torres, R1
Navarro-Ruiz, A1
González-Ferrandez, JA1
Kocabay, G1
Erelel, M1
Tutkun, IT1
Ecder, T1
Ahmad, I1
Clark, LA1
Yolton, DP1
Gallofre López, M1
Latorre Murillo, P1
Massons Cirera, J1
Sumalla Suñe, J1
Polak, BC1
Stricker, BH1
Yoshikawa, TT1
Nagami, PH1
Douche, C1
Rougerie, M1
González-Gay, MA1
Sánchez-Andrade, A1
Agüero, JJ1
Alonso, MD1
Rodriguez, E1
Criado, JR1
Durrheim, DN1
Belt, EL1
To, TQ1
Townsend, JC1
Addington, WW1
McNicol, M1
Albengres, E1
Houin, G1
Breau, JL1
Hirsch, A1
Saltiel, JC1
Tillement, JP1
Chrétien, J1
Nair, KG1
Le Rebeller, MJ1
Fréour, P1
Lagoutte, F1
Garrett, CR1
Byrd, RB1
Kaplan, PD1
Gracey, DR1
Tateishi, J1
Krakowski, D1
Politi, F1
Sachs, R1
Eule, H1
Fichtner, K1
Gross, V1
Sellau, J1
Saraux, H1
Bechetoille, A1
Nou, B1
Citron, KM1
Clarke, GB1
Cuthbert, J1
Cuthbert, RJ1
Lees, AW1
Mikuni, M1
Oishi, M1
Nanba, K1
Brückner, R1
María Palermo, F1
Alberto Iannello, J1
Klein, A1

Reviews

2 reviews available for isoniazid and Optic Neuritis

ArticleYear
[Treatment of tuberculous meningitis in adults: current trends and problems].
    Revista clinica espanola, 1982, Sep-30, Volume: 166, Issue:6

    Topics: Aminosalicylic Acid; Antitubercular Agents; Blood-Brain Barrier; Chemical and Drug Induced Liver Inj

1982
Ethambutol: a review with special reference to ocular toxicity.
    Tubercle, 1969, Volume: 50

    Topics: Aminosalicylic Acids; Drug Resistance, Microbial; Ethambutol; Eye; Humans; Isoniazid; Optic Neuritis

1969

Other Studies

35 other studies available for isoniazid and Optic Neuritis

ArticleYear
Ethambutol and isoniazid induced severe neurotoxicity in a patient undergoing continuous ambulatory peritoneal dialysis.
    BMJ case reports, 2018, May-18, Volume: 2018

    Topics: Adult; Antitubercular Agents; Ethambutol; Humans; Isoniazid; Kidney Failure, Chronic; Male; Optic Ne

2018
Drug-induced optic neuropathy in a case of extensively drug-resistant pulmonary tuberculosis.
    Journal of basic and clinical physiology and pharmacology, 2018, Dec-19, Volume: 30, Issue:1

    Topics: Adult; Antitubercular Agents; Drug Resistance, Bacterial; Drug Therapy, Combination; Humans; Isoniaz

2018
Optic Perineuritis Due to Tuberculosis.
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2019, Volume: 39, Issue:2

    Topics: Adult; Antitubercular Agents; Bronchoscopy; Drug Therapy, Combination; Humans; Isoniazid; Magnetic R

2019
[Macular tuberculoma and optic neuritis: rare association with tuberculosis meningoencephalitis].
    Journal francais d'ophtalmologie, 2009, Volume: 32, Issue:9

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antitubercular Agents; Calcinosis; Confusion; Dip

2009
Bilateral optic neuritis due to isoniazid (INH).
    Indian pediatrics, 2010, Volume: 47, Issue:6

    Topics: Antitubercular Agents; Child; Humans; Isoniazid; Magnetic Resonance Imaging; Male; Optic Neuritis; T

2010
Optic neuritis and anti tubercular therapy.
    Indian pediatrics, 2010, Volume: 47, Issue:10

    Topics: Antitubercular Agents; Child; Humans; Isoniazid; Optic Neuritis; Streptomycin

2010
Optic neuritis following isoniazid therapy.
    Lancet (London, England), 1955, Aug-06, Volume: 269, Issue:6884

    Topics: Disease; Isoniazid; Neuritis; Niacin; Nicotinic Acids; Optic Nerve; Optic Nerve Diseases; Optic Neur

1955
Isoniazid as a cause of optic neuritis and atrophy.
    Journal of the American Medical Association, 1957, Aug-17, Volume: 164, Issue:16

    Topics: Atrophy; Eye Diseases; Humans; Isoniazid; Neuritis; Optic Neuritis

1957
[A CASE OF AN UNUSUALLY SEVERE SENSITIZATION TO ANTIBACTERIAL DRUGS].
    Gruzlica (Warsaw, Poland : 1926), 1963, Volume: 31

    Topics: Adolescent; Adrenal Cortex Hormones; Aminosalicylic Acid; Aminosalicylic Acids; Anti-Bacterial Agent

1963
[APROPOS OF THE TREATMENT OF A CASE OF TUBERCULOUS OPTO-CHIASMATIC ARACHNOIDITIS].
    Bulletin mensuel - Societe de medecine militaire francaise, 1964, Volume: 58

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Arachnoid; Arachnoiditis; Humans; Isoniazid; Optic Chiasm

1964
Optic neuritis with concurrent etanercept and isoniazid therapy.
    The Annals of pharmacotherapy, 2005, Volume: 39, Issue:12

    Topics: Antitubercular Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunog

2005
Optic neuritis and bitemporal hemianopsia associated with isoniazid treatment in end-stage renal failure.
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2006, Volume: 10, Issue:12

    Topics: Adult; Antitubercular Agents; Combined Modality Therapy; Drug Therapy, Combination; Ethambutol; Hemi

2006
Isoniazid hypersensitivity reaction involving the eyes. Report of a case.
    Diseases of the chest, 1967, Volume: 52, Issue:1

    Topics: Adult; Conjunctiva; Drug Hypersensitivity; Female; Hemorrhage; Humans; Isoniazid; Optic Neuritis; Tu

1967
Nutritional effects of zinc on ocular and systemic physiology.
    Journal of the American Optometric Association, 1981, Volume: 52, Issue:5

    Topics: Clioquinol; Dithizone; Ethambutol; Eye Diseases; Humans; Intraocular Pressure; Iodoquinol; Isoniazid

1981
[Optic nerve damage caused by tuberculostatic agents].
    Nederlands tijdschrift voor geneeskunde, 1982, Mar-06, Volume: 126, Issue:10

    Topics: Adult; Ethambutol; Humans; Isoniazid; Male; Optic Neuritis; Tuberculosis, Pleural

1982
Adverse drug reactions in TB therapy: risks and recommendations.
    Geriatrics, 1982, Volume: 37, Issue:7

    Topics: Adult; Age Factors; Aged; Antitubercular Agents; Aspartate Aminotransferases; Chemical and Drug Indu

1982
[Toxic optic neuritis: sometimes wrongly attributed to antituberculosis treatment (author's transl)].
    Journal francais d'ophtalmologie, 1981, Volume: 4, Issue:4

    Topics: Adult; Ethambutol; Ether; Ethyl Ethers; Female; Humans; Isoniazid; Optic Neuritis; Substance-Related

1981
Optic neuritis following treatment with isoniazid in a hemodialyzed patient.
    Nephron, 1993, Volume: 63, Issue:3

    Topics: Arthritis, Infectious; Humans; Isoniazid; Male; Middle Aged; Optic Neuritis; Renal Dialysis; Tubercu

1993
Tuberculosis control programme guidelines--treatment regimens.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1996, Volume: 86, Issue:10

    Topics: Antitubercular Agents; Body Weight; Dose-Response Relationship, Drug; Drug Combinations; Ethambutol;

1996
Ocular toxicity of systemic medications: a case series.
    Optometry (St. Louis, Mo.), 2000, Volume: 71, Issue:1

    Topics: Adult; Aged; Amiodarone; Cataract; Corneal Diseases; Eye Diseases; Female; Glaucoma; Humans; Isoniaz

2000
The side effects and interactions of antituberculosis drugs.
    Chest, 1979, Volume: 76, Issue:6 Suppl

    Topics: Adult; Aminosalicylic Acid; Antitubercular Agents; Central Nervous System Diseases; Chemical and Dru

1979
Treatment of tuberculosis.
    Journal of the Royal College of Physicians of London, 1979, Volume: 13, Issue:1

    Topics: Antitubercular Agents; Chemical and Drug Induced Liver Injury; Costs and Cost Analysis; Drug Hyperse

1979
[Modification during treatment of the rate of acetylation of isoniazide clinically or biologically detectable hepatic damage (author's transl)].
    La Nouvelle presse medicale, 1977, Oct-01, Volume: 6, Issue:32

    Topics: Acetylation; Drug Therapy, Combination; Ethambutol; Humans; Isoniazid; Liver; Male; Optic Neuritis;

1977
Optic neuritis due to INH complicating tuberculous meningitis.
    The Journal of the Association of Physicians of India, 1976, Volume: 24, Issue:4

    Topics: Adult; Humans; Isoniazid; Male; Optic Neuritis; Tuberculosis, Meningeal

1976
[Sensitivo-sensorial neuritis during anti-tubercular treatment].
    Bulletin des societes d'ophtalmologie de France, 1976, Volume: 76, Issue:11

    Topics: Adult; Ethambutol; Female; Humans; Isoniazid; Optic Neuritis; Tuberculosis, Pulmonary; Vision Disord

1976
Optic neuritis in a patient on ethambutol and isoniazid evaluated by visual evoked potentials: case report.
    Military medicine, 1985, Volume: 150, Issue:1

    Topics: Adult; Ethambutol; Evoked Potentials, Visual; Humans; Isoniazid; Male; Optic Neuritis

1985
Treatment of pulmonary tuberculosis.
    Chest, 1974, Volume: 66, Issue:5

    Topics: Capreomycin; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cycloserine; Depression; Drug

1974
Comparative study of neurotoxicity of clioquinol, ethambutol, isoniazid and chloramphenicol in dogs.
    Folia psychiatrica et neurologica japonica, 1974, Volume: 28, Issue:1

    Topics: Abdomen; Administration, Oral; Animals; Axons; Chloramphenicol; Clioquinol; Dogs; Ethambutol; Isonia

1974
[Retrobulbar neuritis due to ethambutol].
    Harefuah, 1974, Aug-15, Volume: 87, Issue:4

    Topics: Amblyopia; Drug Synergism; Drug Therapy, Combination; Ethambutol; Humans; Isoniazid; Male; Middle Ag

1974
[Intermittent 2-phase therapy using ethambutol-INH-streptomycin].
    Zeitschrift fur Erkrankungen der Atmungsorgane mit Folia bronchologica, 1972, Volume: 136, Issue:2

    Topics: Adolescent; Adult; Antitubercular Agents; Drug Synergism; Ethambutol; Female; Humans; Isoniazid; Lon

1972
[Ethambutol induced severe optic neuritis].
    La Nouvelle presse medicale, 1974, Jul-06, Volume: 3, Issue:27

    Topics: Adult; Aged; Chelating Agents; Drug Interactions; Electroretinography; Ethambutol; Ethanol; Evoked P

1974
Isoniazid plus ethambutol in the initial treatment of pulmonary tuberculosis.
    British journal of diseases of the chest, 1972, Volume: 66, Issue:4

    Topics: Aged; Drug Combinations; Drug Resistance, Microbial; Ethambutol; Humans; Isoniazid; Male; Optic Neur

1972
Effects of ethambutol on tuberculous diseases of the eye.
    Acta medica et biologica, 1969, Volume: 16, Issue:2

    Topics: Adolescent; Adult; Aged; Child, Preschool; Ethambutol; Female; Gastrointestinal Diseases; Humans; Is

1969
[Early diagnosis of drug damage to the retina and optic nerve].
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1969, Volume: 1-3, Issue:1

    Topics: Adult; Aged; Anti-Bacterial Agents; Anticoagulants; Antimalarials; Chlorpromazine; Contraceptives, O

1969
[Chronic neuritis and convulsive syndrome following the administration of isoniazid].
    Revista de la Asociacion Medica Argentina, 1965, Volume: 79, Issue:4

    Topics: Adolescent; Female; Humans; Isoniazid; Optic Neuritis; Seizures; Tuberculosis, Pulmonary

1965