Page last updated: 2024-10-29

isoniazid and Neutropenia

isoniazid has been researched along with Neutropenia in 6 studies

Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).

Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.

Research Excerpts

ExcerptRelevanceReference
"Sixteen patients with TB-HIV co-infection received rifabutin 300 mg QD in combination with tuberculosis chemotherapy (initially pyrazinamide, isoniazid and ethambutol then only isoniazid), and were then randomized to receive isoniazid and LPV/r based ART with rifabutin 150 mg tiw or rifabutin 150 mg daily."9.19Randomized pharmacokinetic evaluation of different rifabutin doses in African HIV- infected tuberculosis patients on lopinavir/ritonavir-based antiretroviral therapy. ( Connolly, C; Harries, A; Kellerman, T; Lienhardt, C; McIlleron, H; Naiker, S; Pym, A; Reddy, T; Wiesner, L, 2014)
"Sixteen patients with TB-HIV co-infection received rifabutin 300 mg QD in combination with tuberculosis chemotherapy (initially pyrazinamide, isoniazid and ethambutol then only isoniazid), and were then randomized to receive isoniazid and LPV/r based ART with rifabutin 150 mg tiw or rifabutin 150 mg daily."5.19Randomized pharmacokinetic evaluation of different rifabutin doses in African HIV- infected tuberculosis patients on lopinavir/ritonavir-based antiretroviral therapy. ( Connolly, C; Harries, A; Kellerman, T; Lienhardt, C; McIlleron, H; Naiker, S; Pym, A; Reddy, T; Wiesner, L, 2014)
"Neutropenia is a rare complication of anti-tuberculous therapy and is usually due to a single agent, most frequently isoniazid."3.72G-CSF enables completion of tuberculosis therapy associated with iatrogenic neutropenia. ( Cormican, LJ; Milburn, HJ; Schey, S, 2004)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19904 (66.67)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Naiker, S1
Connolly, C1
Wiesner, L1
Kellerman, T1
Reddy, T1
Harries, A1
McIlleron, H1
Lienhardt, C1
Pym, A1
HANSEN, JE1
WADE, AB1
STAFFORD, JL1
Cormican, LJ1
Schey, S1
Milburn, HJ1
Jenkins, PF1
Williams, TD1
Campbell, IA1
Cornet, A1
Cornu, P1
Dubrisay, J1
Barbier, JP1
Hirsch, JF1
Carnot, F1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pharmacokinetics of Rifabutin Combined With Antiretroviral Therapy in the Treatment of Tuberculosis Patient With HIV Infection in South Africa: A Phase II Trial[NCT00640887]Phase 248 participants (Anticipated)Interventional2009-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for isoniazid and Neutropenia

ArticleYear
Randomized pharmacokinetic evaluation of different rifabutin doses in African HIV- infected tuberculosis patients on lopinavir/ritonavir-based antiretroviral therapy.
    BMC pharmacology & toxicology, 2014, Nov-19, Volume: 15

    Topics: Adult; Anti-HIV Agents; Antibiotics, Antitubercular; Black People; Coinfection; Cross-Over Studies;

2014

Other Studies

5 other studies available for isoniazid and Neutropenia

ArticleYear
Hypersensitivity to isoniazid with neutropenia and thrombocytopenia.
    The American review of respiratory disease, 1961, Volume: 83

    Topics: Agranulocytosis; Humans; Isoniazid; Leukopenia; Neutropenia; Thrombocytopenia

1961
CYCLICAL NEUTROPENIA.
    Oral surgery, oral medicine, and oral pathology, 1963, Volume: 16

    Topics: Agranulocytosis; Ecchymosis; Gingivitis; Gingivitis, Necrotizing Ulcerative; Humans; Isoniazid; Lymp

1963
G-CSF enables completion of tuberculosis therapy associated with iatrogenic neutropenia.
    The European respiratory journal, 2004, Volume: 23, Issue:4

    Topics: Adult; Antibiotics, Antitubercular; Antitubercular Agents; Ethambutol; Granulocyte Colony-Stimulatin

2004
Neutropenia with each standard antituberculosis drug in the same patient.
    British medical journal, 1980, Apr-19, Volume: 280, Issue:6221

    Topics: Aged; Agranulocytosis; Antibiotics, Antitubercular; Ethambutol; Humans; Isoniazid; Leukocyte Count;

1980
[Hematopoietic tuberculosis].
    Annales de medecine interne, 1974, Volume: 125, Issue:4

    Topics: Bone Marrow; Bone Marrow Examination; Cholestasis; Erythema; Ethambutol; Humans; Isoniazid; Leukopen

1974