isoniazid has been researched along with Metabolic Acidosis in 43 studies
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyridoxine hydrochloride, the antidote for isonicotinic acid hydrazide (INH)--induced seizures, is available in solution at a concentration of 100 mg/mL at a pH of less than 3." | 9.09 | Intravenous pyridoxine-induced metabolic acidosis. ( Curry, SC; Graeme, KA; Lovecchio, F; Suchard, J; Wallace, KL, 2001) |
| "Metabolic acidosis is one of the common manifestations of Isoniazid toxicity but rare with normally used doses of the drug." | 7.83 | Isoniazid Induced Metabolic Acidosis and Renal Dysfunction in an Elderly Patient with Chronic Renal Disease. ( Chakrabarti, SS; Gambhir, IS; Kaur, U, 2016) |
| " Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma." | 7.73 | Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. ( Ekici, NZ; Kefi, A; Sakarya, M; Topcu, I; Yentur, EA, 2005) |
| "Acute metabolic acidosis associated with accumulation of lactate has been previously reported in isoniazid (INH) intoxication." | 7.67 | Association of beta hydroxybutyric acidosis with isoniazid intoxication. ( Maksy, M; Nathan, R; Ness, R; Pahl, MV; Vaziri, ND, 1984) |
| "Isoniazid (INH) is an integral component of treatment of tuberculosis." | 5.35 | Isoniazid toxicity presenting as status epilepticus and severe metabolic acidosis. ( Gokhale, YA; Mehta, AD; Rathod, NN; Vaidya, MS, 2009) |
| "She was in respiratory failure, with seizures that could not be stopped with diazepam." | 5.29 | [Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose]. ( Adler, M; Girsh-Solomonovich, Z; Raikhlin-Eisenkraft, B, 1993) |
| "Pyridoxine hydrochloride, the antidote for isonicotinic acid hydrazide (INH)--induced seizures, is available in solution at a concentration of 100 mg/mL at a pH of less than 3." | 5.09 | Intravenous pyridoxine-induced metabolic acidosis. ( Curry, SC; Graeme, KA; Lovecchio, F; Suchard, J; Wallace, KL, 2001) |
| "Metabolic acidosis is one of the common manifestations of Isoniazid toxicity but rare with normally used doses of the drug." | 3.83 | Isoniazid Induced Metabolic Acidosis and Renal Dysfunction in an Elderly Patient with Chronic Renal Disease. ( Chakrabarti, SS; Gambhir, IS; Kaur, U, 2016) |
| " Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma." | 3.73 | Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. ( Ekici, NZ; Kefi, A; Sakarya, M; Topcu, I; Yentur, EA, 2005) |
| "Acute metabolic acidosis associated with accumulation of lactate has been previously reported in isoniazid (INH) intoxication." | 3.67 | Association of beta hydroxybutyric acidosis with isoniazid intoxication. ( Maksy, M; Nathan, R; Ness, R; Pahl, MV; Vaziri, ND, 1984) |
| "Acute isoniazid intoxication is characterised by high mortality and vomiting, seizures, coma and metabolic acidosis as main symptoms." | 3.67 | [Acute isoniazid poisoning]. ( Bode, U; Köster, B; Musch, E; Weber, HP, 1985) |
| "Large doses of pyridoxine recently have been shown to prevent the seizures and acidosis caused by ingestion of more than two to three grams of isoniazid." | 3.66 | Isoniazid overdose treated with high-dose pyridoxine. ( Wood, JP; Yarbrough, BE, 1983) |
| "Isoniazid overdose is a potentially fatal intoxication." | 2.39 | Isoniazid overdose: four case reports and review of the literature. ( Alvarez, FG; Guntupalli, KK, 1995) |
| "Isoniazid (INH) is an integral component of treatment of tuberculosis." | 1.35 | Isoniazid toxicity presenting as status epilepticus and severe metabolic acidosis. ( Gokhale, YA; Mehta, AD; Rathod, NN; Vaidya, MS, 2009) |
| "Pyridoxine was given intravenously as an antidote." | 1.34 | [Isoniazid intoxication]. ( Cyran, J; Graf, J; Radunz, W; Scheffold, N, 2007) |
| "She was in respiratory failure, with seizures that could not be stopped with diazepam." | 1.29 | [Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose]. ( Adler, M; Girsh-Solomonovich, Z; Raikhlin-Eisenkraft, B, 1993) |
| "In all patients generalized seizures and metabolic acidosis developed." | 1.27 | Isoniazid overdose in the Cambodian population of Olmsted County, Minnesota. ( Blanchard, PD; Hurt, RD; McAlpine, DE; Yao, JD, 1986) |
| "We treated five isoniazid-overdosed patients each with a single dose of pyridoxine hydrochloride equivalent to the gram amount of isoniazid ingested and compared their outcome with that of 41 patients from the literature who received little or no pyridoxine." | 1.26 | Single high-dose pyridoxine treatment for isoniazid overdose. ( Lacouture, PG; Lovejoy, FH; Wason, S, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (53.49) | 18.7374 |
| 1990's | 7 (16.28) | 18.2507 |
| 2000's | 10 (23.26) | 29.6817 |
| 2010's | 3 (6.98) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uzman, S | 1 |
| Uludağ Yanaral, T | 1 |
| Toptaş, M | 1 |
| Koç, A | 1 |
| Taş, A | 1 |
| Bican, G | 1 |
| Kaur, U | 1 |
| Chakrabarti, SS | 1 |
| Gambhir, IS | 1 |
| Agrawal, RL | 1 |
| Dwivedi, NC | 1 |
| Agrawal, M | 1 |
| Jain, S | 1 |
| Agrawal, A | 1 |
| Gokhale, YA | 1 |
| Vaidya, MS | 1 |
| Mehta, AD | 1 |
| Rathod, NN | 1 |
| Osterhoudt, KC | 1 |
| Henretig, FM | 1 |
| Frank, I | 1 |
| Lahav, D | 1 |
| Aroch, I | 1 |
| Knapp, JF | 1 |
| Johnson, T | 1 |
| Alander, S | 1 |
| Caksen, H | 1 |
| Odabas, D | 1 |
| Erol, M | 1 |
| Anlar, O | 1 |
| Tuncer, O | 1 |
| Atas, B | 1 |
| EISEMAN, B | 1 |
| MOORE, TC | 1 |
| NORMELL, L | 1 |
| LEMERCIER, JP | 1 |
| DORDAIN, M | 1 |
| SITPRIJA, V | 1 |
| HOLMES, JH | 1 |
| LISSAC, J | 1 |
| POCIDALO, JJ | 1 |
| SACHS, C | 1 |
| Topcu, I | 1 |
| Yentur, EA | 1 |
| Kefi, A | 1 |
| Ekici, NZ | 1 |
| Sakarya, M | 1 |
| Graf, J | 1 |
| Scheffold, N | 1 |
| Radunz, W | 1 |
| Cyran, J | 1 |
| Hayama, N | 1 |
| Pahl, MV | 1 |
| Vaziri, ND | 1 |
| Ness, R | 1 |
| Nathan, R | 1 |
| Maksy, M | 1 |
| Kreisberg, RA | 1 |
| Wood, BC | 1 |
| Yarbrough, BE | 1 |
| Wood, JP | 1 |
| Youssef, W | 1 |
| Cahuana, A | 1 |
| Feijoo, B | 1 |
| Pou, J | 1 |
| Wason, S | 1 |
| Lacouture, PG | 1 |
| Lovejoy, FH | 1 |
| Aggarwal, P | 1 |
| Marcovigi, P | 1 |
| Valtancoli, E | 1 |
| Calbi, P | 1 |
| Farolfi, P | 1 |
| Calbi, G | 1 |
| Adler, M | 1 |
| Girsh-Solomonovich, Z | 1 |
| Raikhlin-Eisenkraft, B | 1 |
| Alvarez, FG | 1 |
| Guntupalli, KK | 1 |
| Chang, YD | 1 |
| Yang, CC | 1 |
| Lin, TJ | 1 |
| Ger, J | 1 |
| Deng, JF | 1 |
| Temmerman, W | 1 |
| Dhondt, A | 1 |
| Vandewoude, K | 1 |
| Piliero, PJ | 1 |
| Fish, DG | 1 |
| Lovecchio, F | 1 |
| Curry, SC | 1 |
| Graeme, KA | 1 |
| Wallace, KL | 1 |
| Suchard, J | 1 |
| Chin, L | 1 |
| Sievers, ML | 2 |
| Herrier, RN | 2 |
| Picchioni, AL | 1 |
| Wattel, F | 1 |
| Gosselin, B | 1 |
| Chopin, C | 1 |
| Durocher, A | 1 |
| Bear, ES | 1 |
| Hoffman, PF | 1 |
| Siegel, SR | 1 |
| Randal, RE | 1 |
| Watkins, RC | 1 |
| Hambrick, EL | 1 |
| Benjamin, G | 1 |
| Chavda, SN | 1 |
| Orlowski, JP | 1 |
| Paganini, EP | 1 |
| Pippenger, CE | 1 |
| Spalding, CT | 1 |
| Buss, WC | 1 |
| Blanchard, PD | 1 |
| Yao, JD | 1 |
| McAlpine, DE | 1 |
| Hurt, RD | 1 |
| Köster, B | 1 |
| Bode, U | 1 |
| Weber, HP | 1 |
| Musch, E | 1 |
| Bleandonu, G | 1 |
| Boye, J | 1 |
| Tschudi-Steiner, I | 1 |
| Brown, CV | 1 |
| Friedman, SA | 1 |
| Terman, DS | 1 |
| Teitelbaum, DT | 1 |
| Schneider, E | 1 |
| Jungbluth, H | 1 |
| Oppermann, F | 1 |
5 reviews available for isoniazid and Metabolic Acidosis
| Article | Year |
|---|---|
[Drug-induced acidosis].
Topics: Acetazolamide; Acid-Base Equilibrium; Acid-Base Imbalance; Acidosis; Biguanides; Central Nervous Sys | 2007 |
Drug and chemical-induced metabolic acidosis.
Topics: Acidosis; Adenosine Triphosphate; Age Factors; Animals; Biguanides; Carbon Monoxide; Catecholamines; | 1983 |
Isoniazid overdose: four case reports and review of the literature.
Topics: Acidosis; Adolescent; Adult; Antitubercular Agents; Drug Overdose; Female; Humans; Isoniazid; Male; | 1995 |
Acute isoniazid intoxication: seizures, acidosis and coma.
Topics: Acidosis; Acute Disease; Adolescent; Antitubercular Agents; Coma; Diagnosis, Differential; Drug Over | 1999 |
[Adverse effects of important long-term-therapeutics].
Topics: Acidosis; Animals; Antidepressive Agents; Antitubercular Agents; Biguanides; Central Nervous System; | 1970 |
1 trial available for isoniazid and Metabolic Acidosis
| Article | Year |
|---|---|
Intravenous pyridoxine-induced metabolic acidosis.
Topics: Acidosis; Adult; Antidotes; Antitubercular Agents; Blood Gas Analysis; Cross-Over Studies; Drug Moni | 2001 |
37 other studies available for isoniazid and Metabolic Acidosis
| Article | Year |
|---|---|
Acute isoniazid intoxication: an uncommon cause of convulsion, coma and acidosis.
Topics: Acidosis; Antitubercular Agents; Coma; Humans; Infusions, Intravenous; Isoniazid; Male; Pyridoxine; | 2013 |
Isoniazid Induced Metabolic Acidosis and Renal Dysfunction in an Elderly Patient with Chronic Renal Disease.
Topics: Acidosis; Aged; Antitubercular Agents; Humans; Isoniazid; Male; Renal Insufficiency, Chronic | 2016 |
Accidental isoniazid poisoning--a report.
Topics: Acidosis; Adolescent; Adult; Antitubercular Agents; Drug Overdose; Electroencephalography; Gastric L | 2008 |
Isoniazid toxicity presenting as status epilepticus and severe metabolic acidosis.
Topics: Acidosis; Adult; Antitubercular Agents; Bicarbonates; Buffers; Diuretics, Osmotic; Female; Humans; I | 2009 |
A 16-year-old with recalcitrant seizures.
Topics: Acidosis; Adolescent; Antitubercular Agents; Female; Humans; Isoniazid; Status Epilepticus | 2012 |
Myocardial necrosis and severe metabolic acidosis associated with isoniazid poisoning in a dog.
Topics: Acidosis; Animals; Antitubercular Agents; Dog Diseases; Dogs; Female; Isoniazid; Liver; Myocardium; | 2002 |
Seizures in a 13-year-old girl.
Topics: Acidosis; Adolescent; Antitubercular Agents; Asia, Southeastern; Communication Barriers; Diagnosis, | 2003 |
Do not overlook acute isoniazid poisoning in children with status epilepticus.
Topics: Acidosis; Antitubercular Agents; Child, Preschool; Diagnosis, Differential; Diazepam; Drug Overdose; | 2003 |
HISTAMINE METABOLISM IN THE ISOLATED PERFUSED PIG LIVER.
Topics: Acidosis; Alkalosis; Animals; Benzoates; Blood Chemical Analysis; Histamine; Iproniazid; Isoniazid; | 1964 |
[ACUTE INTOXICATION BY ISONIAZID].
Topics: Acidosis; Bicarbonates; Blood Gas Analysis; Coma; Drug-Related Side Effects and Adverse Reactions; H | 1963 |
ISONIAZID INTOXICATION.
Topics: Acidosis; Dialysis; Fluid Therapy; Humans; Isoniazid; Neurologic Manifestations; Renal Dialysis; Tox | 1964 |
[ON A CASE OF ACUTE ISONIAZID INTOXICATION. GRAND MAL EPILEPSY WITH SEVERE METABOLIC ACIDOSIS].
Topics: Acidosis; Epilepsy; Epilepsy, Tonic-Clonic; Isoniazid; Seizures; Toxicology | 1965 |
Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication.
Topics: Acidosis; Acute Disease; Adolescent; Anticonvulsants; Antitubercular Agents; Charcoal; Child; Coma; | 2005 |
[Isoniazid intoxication].
Topics: Acidosis; Anticonvulsants; Antidotes; Antitubercular Agents; Diazepam; Female; Humans; Infusions, In | 2007 |
Association of beta hydroxybutyric acidosis with isoniazid intoxication.
Topics: 3-Hydroxybutyric Acid; Acidosis; Adult; Bicarbonates; Diazepam; Female; Humans; Hydroxybutyrates; Is | 1984 |
Isoniazid overdose treated with high-dose pyridoxine.
Topics: Acidosis; Adolescent; Adult; Female; Humans; Isoniazid; Male; Pyridoxine; Seizures | 1983 |
[Acute isoniazid poisoning].
Topics: Acidosis; Child; Coma; Female; Humans; Isoniazid; Seizures | 1983 |
Single high-dose pyridoxine treatment for isoniazid overdose.
Topics: Acidosis; Adolescent; Adult; Bicarbonates; Coma; Female; Humans; Isoniazid; Male; Pyridoxine; Seizur | 1981 |
INH-induced neurotoxicity.
Topics: Acidosis; Adult; Brain; Drug Overdose; Humans; Isoniazid; Pyridoxine; Seizures | 1994 |
[Pyridoxine administration in acute isoniazid intoxication].
Topics: Acidosis; Blood Gas Analysis; Child, Preschool; Coma; Female; Gastric Lavage; Humans; Isoniazid; Poi | 1993 |
[Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose].
Topics: Acidosis; Adolescent; Drug Overdose; Female; Humans; Infusions, Intravenous; Isoniazid; Pyridoxine; | 1993 |
Acute isoniazid intoxication: a case report.
Topics: Acidosis; Acute Disease; Adult; Antitubercular Agents; Coma; Female; Humans; Isoniazid; Seizures | 1996 |
Isoniazid-induced beta-hydroxybutyric acidosis.
Topics: 3-Hydroxybutyric Acid; Acidosis; Adult; AIDS-Related Opportunistic Infections; Drug Interactions; Fe | 2001 |
Convulsions as the etiology of lactic acidosis in acute isoniazid toxicity in dogs.
Topics: Acidosis; Acute Disease; Animals; Antidotes; Bicarbonates; Carbon Dioxide; Dogs; Hydrogen-Ion Concen | 1979 |
[Letter: Massive intoxication by isoniazid. Treatment by peritoneal dialysis].
Topics: Acidosis; Gastric Lavage; Humans; Hydrogen-Ion Concentration; Isoniazid; Male; Peritoneal Dialysis; | 1975 |
Treatment of acute isoniazid toxicity.
Topics: Acidosis; Adolescent; Adult; Airway Obstruction; Anticonvulsants; Bicarbonates; Coma; Diuresis; Fema | 1975 |
Suicidal ingestion of isoniazid: an uncommon cause of metabolic acidosis and seizures.
Topics: Acidosis; Adolescent; Adult; Bicarbonates; Diazepam; Diuresis; Female; Humans; Infusions, Parenteral | 1976 |
Isoniazid toxicity presenting as seizures and metabolic acidosis.
Topics: Acidosis; Adolescent; Humans; Infusions, Intravenous; Isoniazid; Male; Pyridoxine; Seizures | 1990 |
Treatment of a potentially lethal dose isoniazid ingestion.
Topics: Acidosis; Blood Gas Analysis; Child; Coma; Emergencies; Humans; Isoniazid; Male; Oliguria; Renal Dia | 1988 |
Toxic overdose of isoniazid, rifampicin and ethambutol.
Topics: Acidosis; Adult; Alanine Transaminase; Aspartate Aminotransferases; Ethambutol; Female; Humans; Ison | 1986 |
Isoniazid overdose in the Cambodian population of Olmsted County, Minnesota.
Topics: Acidosis; Adolescent; Adult; Asian; Cambodia; Female; Humans; Isoniazid; Life Change Events; Male; M | 1986 |
[Acute isoniazid poisoning].
Topics: Acidosis; Coma; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Infant; Isoniazid; Metab | 1985 |
[Neuropsychiatric incidences in antitubercular treatment consisting of isoniazid or isoniazid and ethionamide (8 cases)].
Topics: Acidosis; Adult; Alcoholism; Ammonia; Avitaminosis; Carboxy-Lyases; Chromatography, Paper; Chromatog | 1969 |
Acute isoniazid poisoning.
Topics: Acidosis; Acute Disease; Adolescent; Adult; Aged; Alaska; Antidotes; Carbon Dioxide; Child; Child, P | 1972 |
Death following massive ingestion of isoniazid.
Topics: Acidosis; Adolescent; Anticonvulsants; Coma; Fever; Gastric Lavage; Humans; Intubation, Intratrachea | 1969 |
Isoniazid self-poisoning.
Topics: Acidosis; Adolescent; Adult; Female; Humans; Isoniazid; Male; Peritoneal Dialysis; Poisoning; Renal | 1970 |
[Acute isoniazid intoxication. Neurological, electroencephalographic and toxicologic examination].
Topics: Acidosis; Adolescent; Alcoholic Intoxication; Anticonvulsants; Blood Chemical Analysis; Buffers; Cen | 1971 |