Page last updated: 2024-10-29

isoniazid and Liver Diseases

isoniazid has been researched along with Liver Diseases in 90 studies

Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).

Liver Diseases: Pathological processes of the LIVER.

Research Excerpts

ExcerptRelevanceReference
"[Purpose] To investigate the frequency and risk factors of severe liver dysfunction in patients receiving isoniazid (INH) mono-therapy for latent tuberculosis infection (LTBI)."7.83[FREQUENCY AND RISK FACTORS OF SEVERE LIVER DYSFUNCTION IN ISONIAZID MONO-THERAPY FOR LATENT TUBERCULOSIS INFECTION]. ( Ito, K, 2016)
"The cornerstone of tuberculosis management is a 6-month course of isoniazid, rifampicin, pyrazinamide and ethambutol."4.84Antituberculosis drug-induced hepatotoxicity: concise up-to-date review. ( Aarnoutse, RE; Boeree, MJ; de Lange, WC; Dekhuijzen, R; Tostmann, A; van der Ven, AJ, 2008)
"[Purpose] To investigate the frequency and risk factors of severe liver dysfunction in patients receiving isoniazid (INH) mono-therapy for latent tuberculosis infection (LTBI)."3.83[FREQUENCY AND RISK FACTORS OF SEVERE LIVER DYSFUNCTION IN ISONIAZID MONO-THERAPY FOR LATENT TUBERCULOSIS INFECTION]. ( Ito, K, 2016)
"Additionally, treating tuberculosis with antibiotics also poses a serious risk of hepatotoxicity in the patient's body."3.01Deciphering the emerging role of phytocompounds: Implications in the management of drug-resistant tuberculosis and ATDs-induced hepatic damage. ( Ahmad, W; Alharbi, JN; Alomary, MN; Alyahya, SA; Ansari, MA; Ansari, SMA; Ather, H; Hani, U; Imran, MA; Islam, N; Jamous, YF; Shoaib, S; Wahab, S, 2023)
"Isoniazid LTBI treatment was associated with reduced MTB reactivation in transplant patients with latent MTB risk factors (0."2.45Tuberculosis in liver transplant recipients: a systematic review and meta-analysis of individual patient data. ( Gould, MK; Holty, JE; Keeffe, EB; Meinke, L; Ruoss, SJ, 2009)
" Pharmacokinetics of selected anti-infective agents are altered in hepatic disease, necessitating careful monitoring and dosage titration to avoid enhanced drug concentrations and risk of toxicity."2.39Anti-infective agents and hepatic disease. ( Tschida, SJ; Vance-Bryan, K; Zaske, DE, 1995)
"Liver diseases are common in patients with HIV due to viral hepatitis B and C co-infections, opportunistic infections or malignancies, antiretroviral drugs and drugs for opportunistic infections."1.35The spectrum of liver diseases in HIV infected individuals at an HIV treatment clinic in Kampala, Uganda. ( Colebunders, R; Feld, J; Kambugu, A; Katabira, E; Katwere, M; Ocama, P; Opio, KC; Piloya, T; Ronald, A; Thomas, D, 2008)
"Isoniazid is a widely used drug for the treatment of tuberculosis, but hepatotoxicity is a major concern during treatment."1.35Protective effects of thiopronin against isoniazid-induced hepatotoxicity in rats. ( Chen, J; Dong, G; He, C; Liu, Y; Peng, R; Yue, J, 2009)
"Family and personal history of mental illness are also predisposing factors."1.31[Behavioral disorders after treatment with isoniazid]. ( Djibo, A; Lawan, A, 2001)
"Acetone pretreatment reduced the inhibition of protein synthesis caused by hydrazine compared to the control."1.29Role of cytochrome P450 in hydrazine toxicity in isolated hepatocytes in vitro. ( Delaney, J; Timbrell, JA, 1995)
"During treatment of active pulmonary tuberculosis with isoniazid, rifampicin and ethambutol in 15 patients transaminase activity increased in seven to levels of 60-340 U/l (group I)."1.26[Plasma levels of rifampicin and isoniazid and serum levels of aminotransferases in combined tuberculostatic treatment (author's transl)]. ( Austerhoff, A; Kindler, U; Knop, P, 1977)

Research

Studies (90)

TimeframeStudies, this research(%)All Research%
pre-199055 (61.11)18.7374
1990's11 (12.22)18.2507
2000's17 (18.89)29.6817
2010's5 (5.56)24.3611
2020's2 (2.22)2.80

Authors

AuthorsStudies
Ansari, MA1
Shoaib, S1
Alomary, MN1
Ather, H1
Ansari, SMA1
Hani, U1
Jamous, YF1
Alyahya, SA1
Alharbi, JN1
Imran, MA1
Wahab, S1
Ahmad, W1
Islam, N1
Mukherjee, TI1
Hirsch-Moverman, Y1
Saito, S1
Gadisa, T1
Melaku, Z1
Howard, AA1
Bourhia, M1
Ullah, R1
S Alqahtani, A1
Ibenmoussa, S1
Moon, HH1
Park, SY1
Kim, JM1
Park, JB1
Kwon, CHD1
Peck, KR1
Kim, SJ1
Lee, SK1
Joh, JW1
Ito, K2
Leise, MD1
Poterucha, JJ1
Talwalkar, JA1
Kumar, N1
Kedarisetty, CK1
Kumar, S1
Khillan, V1
Sarin, SK1
Adhvaryu, MR1
Reddy, N1
Vakharia, BC1
Young, TH1
Tang, HS1
Chao, YC1
Lee, HS1
Hsiong, CH1
Pao, LH1
Hu, OY1
Srivastava, RK1
Sharma, S1
Verma, S1
Arora, B1
Lal, H1
Ocama, P1
Katwere, M1
Piloya, T1
Feld, J1
Opio, KC1
Kambugu, A1
Katabira, E1
Thomas, D1
Colebunders, R1
Ronald, A1
Holty, JE1
Gould, MK1
Meinke, L1
Keeffe, EB1
Ruoss, SJ1
Yue, J1
Dong, G1
He, C1
Chen, J1
Liu, Y1
Peng, R1
ORLOWSKI, EH1
EMMRICH, R1
PETZOLD, H1
CAMBA, R1
COSTA, E1
MURTAS, L1
HAMKE, H1
LE CLAIRE, B1
MCKENNIS, H1
YARD, AS1
PAHNELAS, EV1
NASU, Y1
DIECKHOFF, J1
ZIERZ, P1
PAETZOLD, OH1
IWAINSKY, H1
SIEGEL, D1
GOKCEN, M1
ZINNEMAN, HH1
ALIMOV, RSh1
TANI, P1
POPPIUS, H1
REID, JV1
WRIGHT, R1
Ubaĭdullaev, AM1
Belotserkovets, VG1
Hoshino, H1
Nakazono, T1
Masuyama, H1
Sugita, H1
Yoshiyama, T1
Kato, S1
Jinjuvadia, K1
Kwan, W1
Fontana, RJ1
Xia, YY1
Zhan, SY1
Tostmann, A1
Boeree, MJ1
Aarnoutse, RE1
de Lange, WC1
van der Ven, AJ1
Dekhuijzen, R1
Tayal, V1
Kalra, BS1
Agarwal, S1
Khurana, N1
Gupta, U1
Panchabhai, TS1
Ambarkhane, SV1
Joshi, AS1
Samant, BD1
Rege, NN1
Myles, RK1
DeSwarte, RD1
Teruel, JL1
Marcén, R1
Celma, ML1
Bueno, R1
Jiménez del Cerro, L1
Matesanz, R1
Quereda, C1
Ortuño, J1
Androsov, EE1
Vinokurov, VA1
Garvalinskiĭ, GF1
Karita, VR1
Pogrebinskiĭ, MB1
Holzbach, RT1
Lesar, TS1
Zaske, DE2
Frontera Izquierdo, P1
Unceta Aguirre, L1
Tomás Vila, M1
Calvo Rigual, F1
Pérez Tamarit, D1
Maddrey, WC1
Heathcote, J1
Wanless, IR1
Tschida, SJ1
Vance-Bryan, K1
Hortoneda Giménez, M1
Alfonso Sánchez, JL1
Cortés Vizcaíno, C1
Sabater Pons, A1
Robson, SC1
Pillans, P1
Willcox, PA1
French, SW1
Wong, K1
Jui, L1
Albano, E1
Hagbjork, AL1
Ingelman-Sundberg, M1
Ali, J1
Delaney, J1
Timbrell, JA1
Sodhi, CP2
Rana, SV2
Mehta, SK2
Vaiphei, K2
Attri, S1
Thakur, S1
Mehta, S2
Attari, S1
Wang, T1
Shankar, K1
Ronis, MJ1
Mehendale, HM1
Budak-Alpdogan, T1
Tangün, Y1
Kalayoglu-Besisik, S1
Ratip, S1
Akan, H1
Baslar, Z1
Soysal, T1
Bayik, LA1
Koç, H1
Djibo, A1
Lawan, A1
Kolpakova, TA1
Kolpakov, MA1
Bashkirova, IuV1
Rachkovskaia, LN1
Burylin, SIu1
Liubarskiĭ, MS1
Ziegler, HK1
Sinazadeh, M1
Oldershausen v, HF1
Byrd, RB1
Horn, BR1
Griggs, GA1
Solomon, DA1
Spyridis, P1
Sinaniotis, C1
Papadea, I1
Oreopoulos, L1
Hadjiyiannis, S1
Papadatos, C1
Poupon, RY1
Meyniel, D1
Petit, J1
Gustot, P1
Darnis, F1
Knop, P2
Kindler, U2
Austerhoff, A2
Rosenberg, SA1
Seipp, C1
Sears, HF1
Thompson, JE1
Prescott, LF1
Forrest, JA1
Adjepon-Yamoah, KK1
Finlayson, ND1
Mitchell, JR1
Snodgrass, WR1
Gillette, JR1
O'Brien, RJ1
Goromaru, T1
Sokolova, GB1
Nikolaev, VP1
Braude, VI1
Ziia, AV1
Donald, PR1
Schoeman, JF1
O'Kennedy, A1
Kotal, P1
Jirsa, M1
Klepacek, I1
Martasek, P1
Kordac, V1
Pillans, PI1
Kutt, H1
Levi, AJ1
Sherlock, S1
Walker, D1
Spellberg, MA1
Levin, ML1
Moodie, AS1
LaMont, JT1
Litt, IF1
Schonberg, SK1
Cohen, MI1
Sparks, FC1
Silverstein, MJ1
Hunt, JS1
Haskell, CM1
Pilch, YH1
Morton, DL1
Knieriem, HJ1
Pozzi, E1
Menghini, P1
Efrain Salvioli, J1
Acocella, G1
Clarke, GB1
Cuthbert, J1
Cuthbert, RJ1
Lees, AW1
Brummer, DL1
Verbist, L1
Rollier, F1
Tiitinen, H1
Seki, S1
Nauwald, G1
Palleschi, M1

Reviews

16 reviews available for isoniazid and Liver Diseases

ArticleYear
Deciphering the emerging role of phytocompounds: Implications in the management of drug-resistant tuberculosis and ATDs-induced hepatic damage.
    Journal of infection and public health, 2023, Volume: 16, Issue:9

    Topics: Antitubercular Agents; Bacterial Proteins; Chemical and Drug Induced Liver Injury; Drug Resistance,

2023
Drug-induced liver injury.
    Mayo Clinic proceedings, 2014, Volume: 89, Issue:1

    Topics: Adult; Amoxicillin; Anti-Inflammatory Agents, Non-Steroidal; Causality; Chemical and Drug Induced Li

2014
Antitubercular therapy in patients with cirrhosis: challenges and options.
    World journal of gastroenterology, 2014, May-21, Volume: 20, Issue:19

    Topics: Antitubercular Agents; Ethambutol; Humans; Immune System Diseases; Isoniazid; Latent Tuberculosis; L

2014
Tuberculosis in liver transplant recipients: a systematic review and meta-analysis of individual patient data.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2009, Volume: 15, Issue:8

    Topics: Adult; Antitubercular Agents; Female; Humans; Isoniazid; Liver Diseases; Liver Transplantation; Male

2009
[Systematic review of anti-tuberculosis drug induced adverse reactions in China].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2007, Volume: 30, Issue:6

    Topics: Antitubercular Agents; Chemical and Drug Induced Liver Injury; China; Drug-Related Side Effects and

2007
Antituberculosis drug-induced hepatotoxicity: concise up-to-date review.
    Journal of gastroenterology and hepatology, 2008, Volume: 23, Issue:2

    Topics: Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Humans; In

2008
Drug-induced liver disease.
    Primary care, 1981, Volume: 8, Issue:2

    Topics: Analgesics; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Chlorpromazine; Contracep

1981
Antibiotics and hepatic disease.
    The Medical clinics of North America, 1982, Volume: 66, Issue:1

    Topics: Aminoglycosides; Anti-Bacterial Agents; Chloramphenicol; Clindamycin; Humans; Isoniazid; Kinetics; L

1982
Hepatotoxicity: newer aspects of pathogenesis and treatment.
    The Gastroenterologist, 1995, Volume: 3, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Adenoma, Liver Cell; Adult; Amoxicillin; Anabolic Agents; Beverages;

1995
Anti-infective agents and hepatic disease.
    The Medical clinics of North America, 1995, Volume: 79, Issue:4

    Topics: Anti-Infective Agents; Chloramphenicol; Clindamycin; Fluoroquinolones; Humans; Isoniazid; Liver Dise

1995
[Hepatitis-like liver disorders caused by infections, poisoning and drugs].
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1976, Volume: 82 Pt 1

    Topics: Alcoholism; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Cytomegalovirus Infection

1976
Drug metabolism in liver disease.
    Journal of clinical pathology. Supplement (Royal College of Pathologists), 1975, Volume: 9

    Topics: Acetaminophen; Acute Disease; Antipyrine; Chemical and Drug Induced Liver Injury; Chronic Disease; H

1975
Biochemical and genetic factors regulating dilantin metabolism in man.
    Annals of the New York Academy of Sciences, 1971, Jul-06, Volume: 179

    Topics: Aminosalicylic Acids; Animals; Ataxia; Cats; Chlordan; Cycloserine; DDT; Dicumarol; Disulfiram; Enzy

1971
Postoperative juandice.
    The Surgical clinics of North America, 1974, Volume: 54, Issue:3

    Topics: Aminosalicylic Acids; Anemia, Hemolytic; Bile Ducts; Bilirubin; Chemical and Drug Induced Liver Inju

1974
[Liver diseases induced by drugs].
    Revista clinica espanola, 1967, Aug-15, Volume: 106, Issue:3

    Topics: Animals; Arsenicals; Chemical and Drug Induced Liver Injury; Chloroform; Chlorpromazine; Contracepti

1967
More about isonicotinic acid hydrazide toxicity.
    Food and cosmetics toxicology, 1970, Volume: 8, Issue:5

    Topics: Adenocarcinoma; Adenofibroma; Adenoma; Animals; Carcinoma; Chemical and Drug Induced Liver Injury; C

1970

Trials

5 trials available for isoniazid and Liver Diseases

ArticleYear
Prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach.
    World journal of gastroenterology, 2008, Aug-14, Volume: 14, Issue:30

    Topics: Adult; Antitubercular Agents; Blood Sedimentation; Body Weight; Chemical and Drug Induced Liver Inju

2008
[Use of lymphotropic therapy in the multimodality treatment of patients with pulmonary tuberculosis and comorbidity].
    Problemy tuberkuleza i boleznei legkikh, 2004, Issue:12

    Topics: Administration, Oral; Antitubercular Agents; Diabetes Complications; Ethambutol; Humans; Hypoglycemi

2004
Isoniazid chemoprophylaxis. Association with detection and incidence of liver toxicity.
    Archives of internal medicine, 1977, Volume: 137, Issue:9

    Topics: Adult; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic

1977
Phenylbutazone and isoniazid metabolism in patients with liver disease in relation to previous drug therapy.
    Lancet (London, England), 1968, Jun-15, Volume: 1, Issue:7555

    Topics: Acetylesterase; Acute Disease; Alcoholism; Alkaline Phosphatase; Aspartate Aminotransferases; Barbit

1968
A metabolic and kinetic study on the association rifampicin-isoniazid.
    Respiration; international review of thoracic diseases, 1971, Volume: 28

    Topics: Bilirubin; Chronic Disease; Clinical Trials as Topic; Drug Combinations; Drug Interactions; Humans;

1971

Other Studies

69 other studies available for isoniazid and Liver Diseases

ArticleYear
Determinants of alcohol use among people living with HIV initiating isoniazid preventive therapy in Ethiopia.
    Drug and alcohol dependence, 2019, 11-01, Volume: 204

    Topics: Adult; Alcohol Drinking; Alcoholism; Antitubercular Agents; Catha; Cross-Sectional Studies; Ethiopia

2019
Evidence of drug-induced hepatotoxicity in the Maghrebian population.
    Drug and chemical toxicology, 2022, Volume: 45, Issue:3

    Topics: Adolescent; Adult; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug-Related Side

2022
Isoniazid Prophylaxis for Latent Tuberculosis Infections in Liver Transplant Recipients in a Tuberculosis-Endemic Area.
    Annals of transplantation, 2017, Jun-05, Volume: 22

    Topics: Adolescent; Adult; Aged; Antibiotic Prophylaxis; Antitubercular Agents; Child; Child, Preschool; Fem

2017
[FREQUENCY AND RISK FACTORS OF SEVERE LIVER DYSFUNCTION IN ISONIAZID MONO-THERAPY FOR LATENT TUBERCULOSIS INFECTION].
    Kekkaku : [Tuberculosis], 2016, Volume: 91, Issue:9

    Topics: Adult; Aged; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Humans; Isoniazid; Laten

2016
Quantitative rat liver function test by galactose single point method.
    Laboratory animals, 2008, Volume: 42, Issue:4

    Topics: Alanine Transaminase; Animals; Animals, Laboratory; Aspartate Aminotransferases; Carbon Tetrachlorid

2008
Influence of diabetes on liver injury induced by antitubercular drugs and on silymarin hepatoprotection in rats.
    Methods and findings in experimental and clinical pharmacology, 2008, Volume: 30, Issue:10

    Topics: Animals; Antitubercular Agents; Bilirubin; Chemical and Drug Induced Liver Injury; Diabetes Mellitus

2008
The spectrum of liver diseases in HIV infected individuals at an HIV treatment clinic in Kampala, Uganda.
    African health sciences, 2008, Volume: 8, Issue:1

    Topics: Anti-HIV Agents; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Comorbidity; Female;

2008
Protective effects of thiopronin against isoniazid-induced hepatotoxicity in rats.
    Toxicology, 2009, Oct-29, Volume: 264, Issue:3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Alanine Transaminase; Aniline Compounds; Animals; Aspartate Aminotransf

2009
[Investigations on liver damage and disorders of carbohydrate metabolism due to isonicotinic acid hydrazide using the galactose tolerance test].
    Klinische Wochenschrift, 1952, Nov-15, Volume: 30, Issue:43-4

    Topics: Carbohydrate Metabolism; Carbohydrates; Galactose; Isoniazid; Liver; Liver Diseases; Niacin; Nicotin

1952
[Experimental investigations on liver damage by Rimifon (isonicotinic acid hydrazide)].
    Klinische Wochenschrift, 1952, Dec-01, Volume: 30, Issue:45-6

    Topics: Abdominal Injuries; Isoniazid; Liver; Liver Diseases; Niacin; Nicotinic Acids

1952
[Importance of the liver and the kidneys for the convulsant action of isonicotinic acid hydrazide].
    Archives internationales de pharmacodynamie et de therapie, 1953, Nov-01, Volume: 96, Issue:2

    Topics: Convulsants; Isoniazid; Kidney; Liver Diseases; Niacin; Nicotinic Acids

1953
[The problem of liver lesions caused by isonicotinic acid hydrazide with special reference to blood proteins].
    Die Medizinische, 1955, Oct-01, Issue:40

    Topics: Blood Proteins; Gastrointestinal Diseases; Isoniazid; Liver Diseases; Niacin; Nicotinic Acids

1955
The production of fatty livers in rabbits by isoniazid and other hydrazine derivatives.
    American review of tuberculosis, 1956, Volume: 73, Issue:6

    Topics: Animals; Fatty Liver; Hydrazines; Isoniazid; Liver Diseases; Niacin; Nicotinic Acids; Rabbits

1956
[Investigation of isonicotinic acid hydrazide (INAH) metabolism by azometry. II. INAH metabolism and liver damage].
    Kekkaku : [Tuberculosis], 1957, Volume: 32, Issue:2

    Topics: Isoniazid; Liver Diseases

1957
[Functional studies on the question of liver damage by isoniazid in children].
    Munchener medizinische Wochenschrift (1950), 1957, Sep-27, Volume: 99, Issue:39

    Topics: Abdominal Injuries; Child; Humans; Infant; Isoniazid; Liver Diseases

1957
[Liver damage in isoniazid treatment of cutaneous tuberculosis].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1958, Volume: 9, Issue:5

    Topics: Humans; Isoniazid; Liver Diseases; Tuberculosis; Tuberculosis, Cutaneous

1958
[Metabolism of alpha-ketoacids & the effect of isonicotinic acid hydrazide in experimental liver disorders].
    Beitrage zur Klinik der Tuberkulose und spezifischen Tuberkulose-Forschung, 1959, Volume: 120, Issue:2

    Topics: Biochemical Phenomena; Humans; Isoniazid; Keto Acids; Ketones; Liver Diseases

1959
Liver "autoantibodies" in a case of drug-induced jaundice.
    Gastroenterology, 1963, Volume: 44

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Autoantibodies; Autoimmune Diseases; Drug Hypersensitivit

1963
[EXPERIMENTAL OBSERVATION ON COMPLEX ANTIBACTERIAL THERAPY IN TUBERCULOSIS].
    Medical world, 1963, Volume: 99

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Animals; Anti-Bacterial Agents; Guinea Pigs; Insulin; Iso

1963
SIDE EFFECTS OF AN ANTITUBERCULOUS FIVE-DRUG REGIMEN: ETHIONAMIDE, CYCLOSERINE, PYRAZINAMIDE, VIOMYCIN AND ISONIAZID.
    Acta tuberculosea et pneumologica Scandinavica, 1963, Volume: 43

    Topics: Amyloidosis; Antitubercular Agents; Cycloserine; Deafness; Drug Hypersensitivity; Duodenal Ulcer; Et

1963
CHRONIC SALMONELLOSIS.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1963, Nov-23, Volume: 37

    Topics: Anemia; Black People; Blood Protein Disorders; Child; Chloramphenicol; Eosinophilia; Fever; Hepatome

1963
[Liver damage in treatment of latent tuberculous infection by isoniazid].
    Kekkaku : [Tuberculosis], 2006, Volume: 81, Issue:11

    Topics: Adolescent; Adult; Antitubercular Agents; Asian People; Chemical and Drug Induced Liver Injury; Chil

2006
Searching for a needle in a haystack: use of ICD-9-CM codes in drug-induced liver injury.
    The American journal of gastroenterology, 2007, Volume: 102, Issue:11

    Topics: Adolescent; Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Chemical and Drug Induced Li

2007
Hepatoprotective effect of tocopherol against isoniazid and rifampicin induced hepatotoxicity in albino rabbits.
    Indian journal of experimental biology, 2007, Volume: 45, Issue:12

    Topics: Animals; Antioxidants; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Cimetidine; Do

2007
Protective effect of Tinospora cordifolia, Phyllanthus emblica and their combination against antitubercular drugs induced hepatic damage: an experimental study.
    Phytotherapy research : PTR, 2008, Volume: 22, Issue:5

    Topics: Animals; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; I

2008
Isoniazid hepatotoxicity and acetylation during tuberculosis chemoprophylaxis.
    The American review of respiratory disease, 1980, Volume: 122, Issue:3

    Topics: Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; gamma-Glu

1980
Drug allergy--problems and strategies.
    The Journal of allergy and clinical immunology, 1984, Volume: 74, Issue:3 Pt 1

    Topics: Anaphylaxis; Anemia, Hemolytic; Antigen-Antibody Complex; Desensitization, Immunologic; Dose-Respons

1984
[Hepatopathy in kidney transplant patients: incidence, etiology and clinical forms of presentation].
    Medicina clinica, 1984, May-12, Volume: 82, Issue:18

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Cytomegalovirus Inf

1984
[Isoniazid concentrations in the blood, resected lung tissue and the gallbladder bed in relation to the method of administration to pulmonary tuberculosis patients with stomach and liver diseases].
    Antibiotiki, 1984, Volume: 29, Issue:9

    Topics: Cholecystitis; Gallbladder; Humans; Isoniazid; Liver Diseases; Lung; Pneumonectomy; Stomach Diseases

1984
[Hepatotoxicity of rifampicin and isoniazid in the treatment of tuberculous meningitis (author's transl)].
    Anales espanoles de pediatria, 1981, Volume: 15, Issue:6

    Topics: Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Hepatomegaly; Humans; Infant; Isoni

1981
Isoniazid-induced liver disease.
    Seminars in liver disease, 1981, Volume: 1, Issue:2

    Topics: Adult; Age Factors; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Hepatitis, Vira

1981
[Antitubercular chemoprevention: hepatotoxicity and therapeutic compliance].
    Anales de medicina interna (Madrid, Spain : 1984), 1993, Volume: 10, Issue:12

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alanine Transaminase; Aspartate Aminotransf

1993
Treatment of tuberculosis in patients with pre-existing liver disease or following hepatotoxic drug reactions.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1993, Volume: 83, Issue:6

    Topics: Chemical and Drug Induced Liver Injury; Clinical Protocols; Contraindications; Humans; Isoniazid; Li

1993
Effect of ethanol on cytochrome P450 2E1 (CYP2E1), lipid peroxidation, and serum protein adduct formation in relation to liver pathology pathogenesis.
    Experimental and molecular pathology, 1993, Volume: 58, Issue:1

    Topics: Aldehydes; Animals; Blood Proteins; Cytochrome P-450 Enzyme System; Dietary Fats; Dose-Response Rela

1993
Hepatotoxic effects of tuberculosis therapy. A practical approach to a tricky management problem.
    Postgraduate medicine, 1996, Volume: 99, Issue:5

    Topics: Antibiotics, Antitubercular; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Humans;

1996
Role of cytochrome P450 in hydrazine toxicity in isolated hepatocytes in vitro.
    Xenobiotica; the fate of foreign compounds in biological systems, 1995, Volume: 25, Issue:12

    Topics: Acetone; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A1;

1995
Study of oxidative stress in isoniazid-induced hepatic injury in young rats with and without protein-energy malnutrition.
    Journal of biochemical toxicology, 1996, Volume: 11, Issue:3

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cytoplasm; Frozen Sections; Glutathione; Glutathion

1996
Study of oxidative-stress in isoniazid-rifampicin induced hepatic injury in young rats.
    Drug and chemical toxicology, 1997, Volume: 20, Issue:3

    Topics: Animals; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Glutathione; Glutathione Per

1997
Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:2

    Topics: Alanine Transaminase; Allyl Compounds; Animals; Biotransformation; Chemical and Drug Induced Liver I

2000
The frequency of tuberculosis in adult allogeneic stem cell transplant recipients in Turkey.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2000, Volume: 6, Issue:4

    Topics: Adolescent; Adult; Antitubercular Agents; Female; Graft vs Host Disease; Hematopoietic Stem Cell Tra

2000
[Behavioral disorders after treatment with isoniazid].
    Bulletin de la Societe de pathologie exotique (1990), 2001, Volume: 94, Issue:2

    Topics: Aging; Alcoholism; Antitubercular Agents; Behavior; Contraindications; Diabetes Mellitus; Female; Hu

2001
[Effects of the enterosorbent SUMS-1 on isoniazid pharmacokinetics and lipid peroxidation in patients with pulmonary tuberculosis and drug-induced hepatic lesions].
    Problemy tuberkuleza, 2001, Issue:3

    Topics: Adult; alpha-Tocopherol; Antitubercular Agents; Ceruloplasmin; Chemical and Drug Induced Liver Injur

2001
[Anticonvulsant drugs and liver damage (Author's transl)].
    Journal of neurology, 1975, Volume: 208, Issue:3

    Topics: Adult; Anticonvulsants; Antitubercular Agents; Autopsy; Chemical and Drug Induced Liver Injury; Chol

1975
Isoniazid liver injury during chemoprophylaxis in children.
    Archives of disease in childhood, 1979, Volume: 54, Issue:1

    Topics: Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injur

1979
[Cholestatic hepatitis during treatment with I.N.H. and rifampicin: arguments in favour of the hepatotoxicity of rifampicin (author's transl)].
    Annales de medecine interne, 1979, Volume: 130, Issue:6-7

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Therapy, Combination; Female; Humans

1979
[Plasma levels of rifampicin and isoniazid and serum levels of aminotransferases in combined tuberculostatic treatment (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1977, Dec-30, Volume: 102, Issue:52

    Topics: Adult; Aged; Ethambutol; Female; Humans; Isoniazid; Liver Diseases; Male; Prospective Studies; Rifam

1977
Clinical and immunologic studies of disseminated BCG infection.
    Cancer, 1978, Volume: 41, Issue:5

    Topics: Adult; BCG Vaccine; Bone Marrow Diseases; Female; Fever; Granuloma; Humans; Isoniazid; Liver Disease

1978
How safe is isoniazid?
    The Medical journal of Australia, 1978, Feb-11, Volume: 1, Issue:3

    Topics: Adult; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Hepatitis, Viral, Hu

1978
The role of biotransformation in chemical-induced liver injury.
    Environmental health perspectives, 1976, Volume: 15

    Topics: Acetaminophen; Animals; Biotransformation; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cr

1976
Hepatoxic reaction to antituberculous drugs: Adjustments to therapeutic regimen.
    JAMA, 1991, Jun-26, Volume: 265, Issue:24

    Topics: Antitubercular Agents; Chemical and Drug Induced Liver Injury; Clinical Protocols; Humans; Isoniazid

1991
[Therapeutic drug monitoring of antituberculosis drugs].
    Nihon rinsho. Japanese journal of clinical medicine, 1990, Volume: 48 Suppl

    Topics: Age Factors; Aminosalicylic Acid; Antitubercular Agents; Biological Availability; Dosage Forms; Drug

1990
[Drug prophylaxis of liver lesions induced by isoniazid and its metabolites].
    Problemy tuberkuleza, 1989, Issue:5

    Topics: Animals; Butylated Hydroxytoluene; Chemical and Drug Induced Liver Injury; Female; Inosine Diphospha

1989
Hepatic toxicity during chemotherapy for severe tuberculosis meningitis.
    American journal of diseases of children (1960), 1987, Volume: 141, Issue:7

    Topics: Alanine Transaminase; Antitubercular Agents; Aspartate Aminotransferases; Chemical and Drug Induced

1987
Porphyrinostatic effect of isonicotinic acid hydrazide on porphyric chick embryo and yeast.
    The International journal of biochemistry, 1988, Volume: 20, Issue:11

    Topics: 5-Aminolevulinate Synthetase; Animals; Chick Embryo; Isoniazid; Liver; Liver Diseases; Porphyrias; P

1988
Should the dose of antituberculosis drugs be reduced in patients with liver disease?
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1985, Apr-06, Volume: 67, Issue:14

    Topics: Humans; Isoniazid; Liver Diseases; Rifampin; Tuberculosis

1985
Treatment of infectious granulomas of the liver and infectious mononucleosis. Treatment of hepatic schistosomiasis, tuberculosis, syphilis and echinococcus cyst.
    The American journal of gastroenterology, 1969, Volume: 52, Issue:3

    Topics: Aminosalicylic Acids; Antimony; Antiprotozoal Agents; Benzenesulfonates; Echinococcosis; Esophageal

1969
Preventive therapy of tuberculous infection.
    The American review of respiratory disease, 1974, Volume: 110, Issue:3

    Topics: Administration, Oral; Adult; Age Factors; Chemical and Drug Induced Liver Injury; Child; Humans; Iso

1974
Isoniazid prophylaxis and deaths in Baltimore, 1972.
    Maryland state medical journal, 1974, Volume: 23, Issue:11

    Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Isoniazid; Liver; Liver Disease

1974
Liver disease during adolescence.
    Pediatric clinics of North America, 1973, Volume: 20, Issue:4

    Topics: Acute Disease; Adolescent; Chemical and Drug Induced Liver Injury; Chronic Disease; Contraceptives,

1973
Complications of BCG immunotherapy in patients with cancer.
    The New England journal of medicine, 1973, Oct-18, Volume: 289, Issue:16

    Topics: BCG Vaccine; Fever; Humans; Immunotherapy; Injections; Injections, Intradermal; Isoniazid; Jaundice;

1973
[Liver toxicity of combined rifampicin-isoniazid-ethambutol medication (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1974, May-31, Volume: 99, Issue:22

    Topics: Adolescent; Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bi

1974
Blood levels of rifampicin in liver diseases.
    International journal of clinical pharmacology, therapy and toxicology, 1974, Volume: 10, Issue:1

    Topics: Ethambutol; Humans; Isoniazid; Jaundice; Liver; Liver Diseases; Rifampin; Sulfobromophthalein; Tuber

1974
Isoniazid plus rifampicin in the initial treatment of pulmonary tuberculosis.
    British journal of diseases of the chest, 1972, Volume: 66, Issue:4

    Topics: Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Drug Combinations; Drug Resistance, Mi

1972
Isoniazid and liver disease.
    Annals of internal medicine, 1971, Volume: 75, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Communicable Disease Control; Humans; Isoniazid; Liver Disea

1971
Pharmacological study of rifampicin after repeated high dosage during intermittent combined therapy. II. Bilirubin levels and other biochemical determinations.
    Respiration; international review of thoracic diseases, 1971, Volume: 28

    Topics: Alanine Transaminase; Analysis of Variance; Aspartate Aminotransferases; Bilirubin; Drug Combination

1971
Isoniazid and ethionamide serum levels and inactivation in Finnish subjects.
    Scandinavian journal of respiratory diseases, 1969, Volume: 50, Issue:2

    Topics: Adolescent; Adult; Age Factors; Alcoholism; Ethionamide; Female; Finland; Humans; Injections, Intrav

1969
[Basic studies on the treatment of liver dysfunction. I. Report by the Basic Study Group, Joint Study Unit on the Economic Therapy, Medical Affairs Bureau, Ministry of Health and Welfare].
    Iryo, 1966, Volume: 20, Issue:4

    Topics: Ammonia; Animals; Humans; Isoniazid; Liver Diseases; Rabbits; Tuberculosis

1966
[Complications in the course of tuberculous spondylitis].
    Archiv fur orthopadische und Unfall-Chirurgie, 1966, Volume: 60, Issue:4

    Topics: Cardiovascular Diseases; Central Nervous System Diseases; Female; Gallbladder Diseases; Gastrointest

1966
[Collateral effects of isonicotinic acid hydrazide].
    La Clinica terapeutica, 1966, Volume: 39, Issue:6

    Topics: Blood Coagulation Disorders; Drug Hypersensitivity; Humans; Isoniazid; Liver Diseases; Nervous Syste

1966