Page last updated: 2024-10-29

isoniazid and Leprosy

isoniazid has been researched along with Leprosy in 123 studies

Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).

Leprosy: A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.

Research Excerpts

ExcerptRelevanceReference
"A clinical trial was initiated at ALERT, Addis Ababa, Ethiopia, to study the effect of one-year supplementary treatment on the incidence of dapsone-resistant leprosy in lepromatous patients already on dapsone monotherapy."9.05Relapse rate and incidence of dapsone resistance in lepromatous leprosy patients in Addis Ababa: risk factors and effect of short-term supplementary treatment. ( Mengistu, G; Warndorff van Diepen, T, 1985)
"In Paraguay, the National Leprosy/Tuberculosis Program is based on a combined chemotherapy with isoprodian and rifampicin."7.67Isoprodian and rifampicin in the treatment of leprosy: a descriptive evaluation of therapy durations in 475 Paraguayan leprosy patients. ( Alvarenga, AE; Haubitz, I; Leguizamon, O; Pritze, S, 1989)
"Since 1970, when the lifelong monotherapy with dapsone (DDS) in leprosy could be replaced by short-term combination therapy with rifampicin + isoniazid + protionamide + DDS (Isoprodian-RMP), chemotherapeutic research was faced with two problems: (1) to find alternative treatment regimens for cases of intolerance, and (2) to work out forms of therapy allowing a further reduction of the average treatment time of 2 years."7.67New forms of multidrug therapy for the treatment of leprosy. First report for the practice on rifampicin + sulfamethoxazole-trimethoprim + protionamide and rifampicin + sulfamethoxazole-trimethoprim + isoniazid. ( Freerksen, E; Rosenfeld, M; Spannuth, G, 1989)
"Pyrazinamide in a dose of 1500 mg was given to 63 borderline lepromatous (BL) and lepromatous (LL) leprosy patients on different drug regimens for the initial 2 months of therapy."5.06Pyrazinamide as a part of combination therapy for BL and LL patients--a preliminary report. ( Katoch, K; Ramanathan, U; Ramu, G, 1988)
"A clinical trial was initiated at ALERT, Addis Ababa, Ethiopia, to study the effect of one-year supplementary treatment on the incidence of dapsone-resistant leprosy in lepromatous patients already on dapsone monotherapy."5.05Relapse rate and incidence of dapsone resistance in lepromatous leprosy patients in Addis Ababa: risk factors and effect of short-term supplementary treatment. ( Mengistu, G; Warndorff van Diepen, T, 1985)
" leprae has been reported to be a pseudogene, implicating that isoniazid, which is activated to a potent tuberculocidal agent by catalase, is unlikely to be of therapeutic benefit to leprosy patients."3.71Identification of catalase-like activity from Mycobacterium leprae and the relationship between catalase and isonicotinic acid hydrazide (INH). ( Chae, GT; Kang, TJ; You, JC, 2001)
"In Paraguay, the National Leprosy/Tuberculosis Program is based on a combined chemotherapy with isoprodian and rifampicin."3.67Isoprodian and rifampicin in the treatment of leprosy: a descriptive evaluation of therapy durations in 475 Paraguayan leprosy patients. ( Alvarenga, AE; Haubitz, I; Leguizamon, O; Pritze, S, 1989)
"Since 1970, when the lifelong monotherapy with dapsone (DDS) in leprosy could be replaced by short-term combination therapy with rifampicin + isoniazid + protionamide + DDS (Isoprodian-RMP), chemotherapeutic research was faced with two problems: (1) to find alternative treatment regimens for cases of intolerance, and (2) to work out forms of therapy allowing a further reduction of the average treatment time of 2 years."3.67New forms of multidrug therapy for the treatment of leprosy. First report for the practice on rifampicin + sulfamethoxazole-trimethoprim + protionamide and rifampicin + sulfamethoxazole-trimethoprim + isoniazid. ( Freerksen, E; Rosenfeld, M; Spannuth, G, 1989)
"A comparative study with 2 tier and 3 tier combination of Rifampicin, Clofazimine, DDS, INAH and Thiacetazone was conducted on fifty lepromatous leprosy cases for varying periods."3.66Multiple drug therapy--a comparative study with 2 tier and 3 tier combination of rifampicin, clofazimine, DDS, INAH and thiacetazone in lepromatous cases. ( Chaudhury, S; Ghosh, S; Hazra, S; Kundu, SK, 1981)
"In Africa leprosy is considered endemic."1.28[Leprosy in Africa. Current status and epidemiological significance]. ( Stingl, P, 1992)
" The results revealed that the strain, SR61-L74, was almost completely resistant to DDS, and responded only to the long-term administration of Streptomycin and Isoniazid."1.26In vitro resistance test of human leprosy bacilli to anti-leprous drugs. ( Fujuda, T; Hagiwara, S; Ishihara, S, 1977)
" The common side effect in all cases consisted of red and dark skin pigmentation of varying intensity occuring within 10 weeks of the commencement of therapy."1.26Side effects of clofazimine therapy. ( Iyer, GG; Ramu, G, 1976)

Research

Studies (123)

TimeframeStudies, this research(%)All Research%
pre-1990113 (91.87)18.7374
1990's6 (4.88)18.2507
2000's2 (1.63)29.6817
2010's2 (1.63)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bera, S1
Mondal, D1
Jacobson, RR1
Gatt, P1
Trindade, MÂ1
Miyamoto, D1
Benard, G1
Sakai-Valente, NY1
Vasconcelos, Dde M1
Naafs, B1
LOWE, J1
SECRET, E2
GOULDING, R1
ROBSON, JM3
REES, RJ4
LEVADITI, C1
VAISMAN, A1
CHAIGNEAU-ERHARD, H1
FERNANDEZ, JM1
COMPA, F1
MERCAN, AR1
GRUNBERG, E1
TITSWORTH, EH1
COSTELLO, MJ2
LATAPI, F1
BARBA RUBIO, J1
RODRIGUEZ, O1
CASTRO ESTRADA, S1
BERTACCINI, G1
ARGUELLO PITT, L1
CONSIGLI, CA1
TAYLOR, WH1
DIRECTOR, W1
LYSIAK, R1
CORMIA, FE1
BARKER, LP1
NELSON, CT1
WILSON, EW1
CRAMER, JA1
PREZIOSI, P1
CHAUSSINAND, R4
VIETTE, M4
KRUG, O3
DEZEST, G1
GABBAI, A1
DORENLOT, H1
FLOCH, H2
SUREAU, P1
DE LIMA, SO1
JOPLING, WH2
RIDLEY, DS2
SIGALL, O1
DAVIDSON, WS2
MARKIANOS, J1
JAIME MELAMED, A1
CRUICKSHANK, JC1
MUDROW-REICHENOW, L1
GUSSENHOVEN, GA2
HOBBY, GL1
DONIKIAN, MA1
FIOL, H1
GARRETT, A1
SCRAGG, RF1
MAGALHAES, MJ1
NAGUIB, M1
HIRANO, N6
SUSHIDA, K6
KIMMIG, J1
MEYER-ROHN, J1
DREISBACH, J1
COCHRANE, RG1
OCHIAI, Y1
MATSUDA, S1
HEITE, HJ1
RAUSCH, L1
EKAMBARAM, V1
SHARMA, CS1
SHEPARD, CC1
CHANG, YT1
SMITH, AE1
WHEATE, HW1
FLOCH, T1
KAWAGUCHI, Y1
Karat, AB1
Rao, PS1
Karat, S1
Job, CK1
Kundu, SK1
Ghosh, S1
Hazra, S1
Chaudhury, S1
Ramu, G4
Stanley, JN2
Pearson, JM2
Ellard, GA4
Freerksen, E8
Styblo, K1
Pattyn, SR1
Portaels, F1
Van Loo, G1
Van den Breen, L1
Venkatesan, K1
Bharadwaj, VP1
Desikan, KV1
Smith, TC1
Richardus, JH1
Verduin, PR1
van Brakel, WH1
Drever, W1
Eiglmeier, K1
Fsihi, H1
Heym, B1
Cole, ST1
Kang, TJ1
You, JC1
Chae, GT1
Schlaegel, TF1
O'Connor, GR1
Rosenfeld, M5
Ishihara, S1
Hagiwara, S1
Fujuda, T1
Bonnici, E2
Depasquale, G4
Kriiger-Thiemer, M1
Iyer, GG1
De Las Aguas, JT1
Terencio de las Aguas, J1
Innami, S1
Leguizamón, OR1
Alvarenga, AE3
Hamzah, M1
Kosasih, A1
Krenzien, HN1
Rohde, R1
Aschhoff, M1
Stingl, P1
Aoyagi, T1
Toyoda, T1
Warndorff van Diepen, T1
Mengistu, G1
Katoch, K1
Ramanathan, U1
Pritze, S1
Leguizamon, O1
Haubitz, I1
Spannuth, G1
Antia, NH1
Ambrose, EJ1
Upleker, MW1
Mahadevan, PR1
Mester, L1
Grosset, JH1
Baohong, J1
Ito, T1
Leiker, DL1
Dietrich, M1
Wabitsch, R1
Chum, HJ1
Parikh, DA1
Maniar, JK1
Parikh, AC1
Ganapati, R1
Schirren, C1
Piening, E1
Wagner, WH1
Contreras Duenas, F1
Banerjee, DK1
Gammon, PT2
Waters, MF1
Helmy, HS1
Leiber, DL1
Verhagen, AR2
Blenska, W1
Kolakowska, E1
Agius-Ferrante, A1
Paris, C1
Grima, W1
Urabe, K1
Saito, H1
Hosokawa, H1
Ilardi, I1
Mazzacurati, G1
Vischer, WA1
Yeats, RO1
Peters, JH1
Levy, L1
Lal, HM1
Sasaki, N1
Schulz, EJ1
Egnal, ML1
Doevendans, G1
Laugier, P1
Ellena, V1
Barale, T1

Reviews

6 reviews available for isoniazid and Leprosy

ArticleYear
Insights of synthetic analogues of anti-leprosy agents.
    Bioorganic & medicinal chemistry, 2019, 07-01, Volume: 27, Issue:13

    Topics: Humans; Leprostatic Agents; Leprosy; Structure-Activity Relationship

2019
Leprosy and tuberculosis co-infection: clinical and immunological report of two cases and review of the literature.
    The American journal of tropical medicine and hygiene, 2013, Volume: 88, Issue:2

    Topics: Adult; Brazil; Coinfection; Female; Humans; Immunity, Cellular; Interferon-gamma; Interleukin-12; Is

2013
Leprosy. A preliminary review of the experimental evaluation of drugs for the treatment of leprosy.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1967, Volume: 61, Issue:4

    Topics: Aminosalicylic Acids; Animals; Anti-Bacterial Agents; Antitubercular Agents; Cycloserine; Ethambutol

1967
[New methods of experimental chemotherapy in leprosy].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1969, Volume: 20, Issue:9

    Topics: Aminobenzoates; Animals; Culture Techniques; Dapsone; Ethambutol; Isoniazid; Leprosy; Mice; Mycobact

1969
Recent advances in the study of the leprosy bacillus.
    The Scientific basis of medicine annual reviews, 1969

    Topics: Animals; Cricetinae; Dapsone; Drug Resistance, Microbial; Humans; Isoniazid; Leprosy; Mice; Microbia

1969
[Therapy of leprosy].
    La Clinica terapeutica, 1969, Feb-15, Volume: 48, Issue:3

    Topics: Cycloserine; Humans; Isoniazid; Leprosy; Oils; Plant Extracts; Prognosis; Salicylates; Streptomycin;

1969

Trials

10 trials available for isoniazid and Leprosy

ArticleYear
Treatment of leprosy with rifampicin and isoprodian (L73A).
    Leprosy review, 1975, Volume: 46, Issue:2 Suppl

    Topics: Clinical Trials as Topic; Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Iso

1975
Clinical and bacteriological effects of rifampicin in combination with L73A in leprosy: observation for six months.
    Leprosy review, 1975, Volume: 46, Issue:2 Suppl

    Topics: Clinical Trials as Topic; Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Isoniazid;

1975
Rifampicin and isoprodian in combination in the treatment of leprosy.
    Leprosy review, 1975, Volume: 46, Issue:2 Suppl

    Topics: Clinical Trials as Topic; Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Isoniazid;

1975
Preliminary experience with rifampicin and isoprodian (L73A)--combination in lepromatous leprosy.
    Leprosy review, 1975, Volume: 46, Issue:2 Suppl

    Topics: Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Dapsone; Drug Combinations; Drug Therapy,

1975
Preliminary experience with rifampicin and isoprodian in combination in leprosy treatment.
    Leprosy review, 1975, Volume: 46, Issue:2 Suppl

    Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Dapsone; Drug Combinations; Dr

1975
Report of combined therapy in leprosy with rifampicin and isoprodian conducted at the Bisidimo-center, Ethiopia.
    Leprosy review, 1975, Volume: 46, Issue:2 Suppl

    Topics: Clinical Trials as Topic; Dapsone; Drug Combinations; Drug Therapy, Combination; Ethiopia; Female; H

1975
Relapse rate and incidence of dapsone resistance in lepromatous leprosy patients in Addis Ababa: risk factors and effect of short-term supplementary treatment.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1985, Volume: 53, Issue:2

    Topics: Adolescent; Adult; Dapsone; Drug Combinations; Drug Resistance; Humans; Isoniazid; Leprosy; Recurren

1985
Pyrazinamide as a part of combination therapy for BL and LL patients--a preliminary report.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1988, Volume: 56, Issue:1

    Topics: Adolescent; Adult; Animals; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Isoniaz

1988
Effect of deoxyfructoserotonin (DFS) on lepromatous leprosy.
    Lancet (London, England), 1988, Mar-19, Volume: 1, Issue:8586

    Topics: Adult; Biopsy; Capsules; Clinical Trials as Topic; Humans; Isoniazid; Leprostatic Agents; Leprosy; M

1988
Comparison of DDS with two combined chemotherapy regimens for multibacillary leprosy. Results after 3 years of treatment. A prospective randomized multicentre study.
    Leprosy review, 1986, Volume: 57 Suppl 3

    Topics: Adult; Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Isoniazid; Isonicotini

1986

Other Studies

107 other studies available for isoniazid and Leprosy

ArticleYear
Can leprosy be eradicated with chemotherapy? An evaluation of the Malta Leprosy Eradication Project.
    Leprosy review, 2008, Volume: 79, Issue:4

    Topics: Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Isoniazid; Leprostatic Agents

2008
Isoniazid in leprosy.
    Lancet (London, England), 1952, Nov-22, Volume: 2, Issue:6743

    Topics: Isoniazid; Leprosy; Niacin; Nicotinic Acids

1952
[Trial treatment of leprosy with isoniazid].
    Maroc medical, 1952, Volume: 31, Issue:325

    Topics: Isomerism; Isoniazid; Leprosy; Niacin; Nicotinic Acids

1952
Intracorneal murine leprosy and its response to isoniazid.
    Lancet (London, England), 1953, Feb-28, Volume: 1, Issue:6757

    Topics: Isoniazid; Leprosy; Niacin; Nicotinic Acids

1953
[Isonicotinic acid hydrazide in the treatment of leprosy].
    Actas dermo-sifiliograficas, 1952, Volume: 44, Issue:3

    Topics: Isoniazid; Leprosy; Niacin; Nicotinic Acids

1952
[Therapeutic activity of isonicotinic acid hydrazide in murine leprosy].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences, 1953, Feb-02, Volume: 236, Issue:5

    Topics: Actinomycetales Infections; Isomerism; Isoniazid; Leprosy; Niacin; Nicotinic Acids

1953
[Treatment of leprosy with isonicotinic acid hydrazide; preliminary communication].
    El Dia medico, 1953, Feb-16, Volume: 25, Issue:7

    Topics: Communication; Isomerism; Isoniazid; Leprosy; Niacin; Nicotinic Acids

1953
Preliminary note on the effect of isoniazid and iproniazid in murine leprosy.
    American review of tuberculosis, 1953, Volume: 67, Issue:5

    Topics: Actinomycetales Infections; Iproniazid; Isoniazid; Leprosy; Niacin; Nicotinic Acids

1953
Leprosy (lepromatous type) improved by isoniazid (hydrazid; isonicotinic acid hydrazid).
    A.M.A. archives of dermatology and syphilology, 1953, Volume: 68, Issue:2

    Topics: Isomerism; Isoniazid; Isonicotinic Acids; Leprosy; Niacin; Nicotinic Acids

1953
Report on 9 months' treatment of leprosy with isoniazid (nydrazid).
    The Journal of investigative dermatology, 1953, Volume: 21, Issue:1

    Topics: Isomerism; Isoniazid; Leprosy; Niacin; Nicotinic Acids

1953
[First tests of isonicotinic acid hydrazide therapy of leprosy].
    Minerva dermatologica, 1953, Volume: 28, Issue:5

    Topics: Isomerism; Isoniazid; Leprosy; Niacin; Nicotinic Acids

1953
[Treatment of leprosy with isonicotinic acid hydrazide; preliminary communication].
    Prensa medica argentina, 1953, Jul-31, Volume: 40, Issue:31

    Topics: Communication; Isomerism; Isoniazid; Leprosy; Niacin; Nicotinic Acids

1953
The treatment of leprosy with isonicotinyl hydrazine; a case report.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1953, Volume: 47, Issue:4

    Topics: Isoniazid; Leprosy; Niacin; Nicotinic Acids

1953
Leprosy, lepromatous type: response to isoniazid therapy.
    A.M.A. archives of dermatology and syphilology, 1953, Volume: 68, Issue:4

    Topics: Isomerism; Isoniazid; Leprosy; Niacin; Nicotinic Acids

1953
Isoniazid (nydrazid) in treatment of cutaneous diseases; Cutaneous tuberculosis, leprosy, sarcoidosis, and miscellaneous dermatoses.
    A.M.A. archives of dermatology and syphilology, 1953, Volume: 68, Issue:5

    Topics: Isoniazid; Leprosy; Niacin; Nicotinic Acids; Sarcoidosis; Skin Diseases; Tuberculosis; Tuberculosis,

1953
[Use of isoniazid in leprosy].
    La Riforma medica, 1953, Aug-08, Volume: 67, Issue:32

    Topics: Isomerism; Isoniazid; Leprosy; Niacin; Nicotinic Acids

1953
[Treatment of leprosy by isoniazid].
    La Presse medicale, 1953, Oct-24, Volume: 61, Issue:68

    Topics: Isomerism; Isoniazid; Leprosy; Niacin; Nicotinic Acids

1953
[Effect of isonicotinic acid hydrazide on the rat infected with Mycobacterium lepraemurium].
    Annales de l'Institut Pasteur, 1953, Volume: 84, Issue:2

    Topics: Animals; Isomerism; Isoniazid; Leprosy; Mycobacterium lepraemurium; Niacin; Nicotinic Acids; Rats

1953
[Sixty-two cases of leprosy treated with isoniazid].
    Maroc medical, 1953, Volume: 32, Issue:339

    Topics: Isomerism; Isoniazid; Leprosy; Niacin; Nicotinic Acids

1953
[Development of infection with Mycobacterium lepraemurium in the rat treated with isonicotinic acid hydrazide].
    Annales de l'Institut Pasteur, 1953, Volume: 85, Issue:3

    Topics: Animals; Isomerism; Isoniazid; Leprosy; Mycobacterium lepraemurium; Niacin; Nicotinic Acids; Rats

1953
[Effect of isonicotinic acid hydrazide on Hansen's disease].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1953, Volume: 46, Issue:6

    Topics: Isomerism; Isoniazid; Leprosy; Niacin; Nicotinic Acids; Sulfones

1953
[Place of isoniazid in leprosy therapy].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1953, Volume: 46, Issue:6

    Topics: Isomerism; Isoniazid; Leprosy; Niacin; Nicotinic Acids; Sulfones; Thiosemicarbazones

1953
[Treatment of pulmonary tuberculosis with Hansen's disease by streptomycin-isoniazid injections].
    Hospital (Rio de Janeiro, Brazil), 1954, Volume: 45, Issue:1

    Topics: Isoniazid; Leprosy; Niacin; Nicotinic Acids; Streptomycin; Tuberculosis; Tuberculosis, Pulmonary

1954
Isoniazid in lepromatous leprosy.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1954, Volume: 48, Issue:2

    Topics: Isoniazid; Leprosy; Leprosy, Lepromatous; Niacin; Nicotinic Acids

1954
[Treatment of lepromatous leprosy with isonicotinic acid hydrazide: advance notice].
    Arquivos mineiros de leprologia, 1953, Volume: 13, Issue:3

    Topics: Isomerism; Isoniazid; Leprosy; Leprosy, Lepromatous; Niacin; Nicotinic Acids

1953
Isoniazid alone and in combination with other drugs in the treatment of leprosy.
    Leprosy review, 1954, Volume: 25, Issue:2

    Topics: Isoniazid; Leprosy; Niacin; Nicotinic Acids

1954
[Therapeutic effect of isonicotinic acid hydrazide in leprosy].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1954, Volume: 47, Issue:1

    Topics: Isomerism; Isoniazid; Leprosy; Niacin; Nicotinic Acids

1954
[Leprosy reaction: prophylactic action of isoniazid].
    El Dia medico, 1954, May-27, Volume: 26, Issue:34

    Topics: Isomerism; Isoniazid; Leprosy; Niacin; Nicotinic Acids

1954
Isoniazid in the treatment of rat leprosy.
    Lancet (London, England), 1954, Sep-11, Volume: 267, Issue:6837

    Topics: Animals; Isoniazid; Leprosy; Niacin; Nicotinic Acids; Rats

1954
[The effects of isoniazid on the pathogen of rat leprosy].
    Zeitschrift fur Tropenmedizin und Parasitologie, 1954, Volume: 5, Issue:2

    Topics: Animals; Isomerism; Isoniazid; Leprosy; Mycobacterium; Niacin; Nicotinic Acids; Rats

1954
[Isonicotinic acid hydrazide therapy of leprosy].
    Nederlands tijdschrift voor geneeskunde, 1954, Sep-04, Volume: 98, Issue:36

    Topics: Isoniazid; Leprosy; Niacin; Nicotinic Acids

1954
Isoniazid alone and combined with thiosemicarbazone.
    Leprosy review, 1955, Volume: 26, Issue:3

    Topics: Isoniazid; Leprosy; Niacin; Nicotinic Acids; Thiosemicarbazones

1955
Treatment of leprosy patients with isonicotinic acid hydrazide.
    Documenta de medicina geographica et tropica, 1955, Volume: 7, Issue:3

    Topics: Isomerism; Isoniazid; Leprosy; Niacin; Nicotinic Acids

1955
Isoniazid with sulphones in lepromatous leprosy.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1955, Volume: 49, Issue:5

    Topics: Adrenal Cortex; Isoniazid; Leprosy; Leprosy, Lepromatous; Niacin; Nicotinic Acids; Sulfones

1955
The intermittent use of streptomycin and isoniazid singly and together in murine leprosy.
    American review of tuberculosis, 1955, Volume: 72, Issue:6

    Topics: Actinomycetales Infections; Animals; Humans; Isoniazid; Leprosy; Mice; Niacin; Nicotinic Acids; Stre

1955
[Treatment of leprosy with isonicotinic acid hydrazide].
    Prensa medica argentina, 1955, Jul-01, Volume: 42, Issue:26

    Topics: Isomerism; Isoniazid; Leprosy; Niacin; Nicotinic Acids

1955
Isoniazid in leprosy treatment.
    Leprosy review, 1955, Volume: 26, Issue:4

    Topics: Isoniazid; Leprosy; Niacin; Nicotinic Acids

1955
Isoniazid in leprosy.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1955, Volume: 49, Issue:6

    Topics: Isoniazid; Leprosy; Niacin; Nicotinic Acids

1955
[The place of isoniazid and the thiosemicarbazones in the treatment of leprosy].
    Jornal do medico, 1955, Dec-24, Volume: 28, Issue:674

    Topics: Isomerism; Isoniazid; Leprosy; Niacin; Nicotinic Acids; Thiosemicarbazones

1955
The activity of diethyldithiolisophthalate alone and combined with isoniazid in the treatment of murine leprosy in the mouse cornea.
    Lancet (London, England), 1956, Apr-14, Volume: 270, Issue:6920

    Topics: Cornea; Isoniazid; Leprosy; Niacin; Nicotinic Acids; Sulfhydryl Compounds

1956
[Chemotherapy of murine leprosy; the effects of isonicotinoyl-3-methoxy-4-hydroxybenzal hydrazone].
    Yokohama medical bulletin, 1956, Volume: 7, Issue:2

    Topics: Actinomycetales Infections; Animals; Humans; Hydrazones; Isoniazid; Leprosy; Mice

1956
[Chemotherapy of murine leprosy; the effects of isonicotinoyl-3-methoxy-4-hydroxybenzal hydrazone].
    Yokohama medical bulletin, 1956, Volume: 7, Issue:2

    Topics: Actinomycetales Infections; Animals; Humans; Hydrazones; Isoniazid; Leprosy; Mice

1956
[Chemotherapy of murine leprosy; the effects of isonicotinoyl-3-methoxy-4-hydroxybenzal hydrazone].
    Yokohama medical bulletin, 1956, Volume: 7, Issue:2

    Topics: Actinomycetales Infections; Animals; Humans; Hydrazones; Isoniazid; Leprosy; Mice

1956
[Chemotherapy of murine leprosy; the effects of isonicotinoyl-3-methoxy-4-hydroxybenzal hydrazone].
    Yokohama medical bulletin, 1956, Volume: 7, Issue:2

    Topics: Actinomycetales Infections; Animals; Humans; Hydrazones; Isoniazid; Leprosy; Mice

1956
[New observations on the effect of isonicotinic acid hydrazide in murine infection caused by Stefansky bacillus].
    Annales de l'Institut Pasteur, 1955, Volume: 88, Issue:3

    Topics: Animals; Bacillus; Insecta; Isoniazid; Leprosy; Mice

1955
Chemotherapy of murine leprosy. II. The effects of isonicotinoyl-3. 4-dimethoxybenzal hydrazone.
    Yokohama medical bulletin, 1957, Volume: 8, Issue:2

    Topics: Actinomycetales Infections; Animals; Humans; Hydrazones; Isoniazid; Leprosy; Mice

1957
[Chemotherapy of Stefansky leprosy with N-acetyl-D-glucosaminyl-isoniazid & [beta-methyl-mercaptopropionaldehyde]isonicotinic acid hydrazone].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1957, Volume: 8, Issue:7

    Topics: Aldehydes; Glucosamine; Hydrazones; Isoniazid; Isonicotinic Acids; Leprosy

1957
Chemotherapy of murine leprosy. 3. The effects of isonicotinoyl-3-methoxy-4-ethoxybenzal hydrazone and isoniciotinoyl-3.4-diethoxybenzal hydrazone.
    Yokohama medical bulletin, 1958, Volume: 9, Issue:1

    Topics: Animals; Humans; Hydrazones; Isoniazid; Leprosy; Mice

1958
A study of the effect of streptohydrazid on lepromatous leprosy over a period of about three years.
    Leprosy review, 1958, Volume: 29, Issue:3

    Topics: Isoniazid; Leprosy; Leprosy, Lepromatous; Streptomycin

1958
Paper electrophoretic analysis of sera from leprous mice treated with INH and its derivatives.
    Yokohama medical bulletin, 1959, Volume: 10, Issue:1

    Topics: Animals; Blood Proteins; Electrophoresis, Paper; Isoniazid; Leprosy; Mice; Oxidation-Reduction

1959
Chemotherapy of murine leprosy. 4. The effects of isonicotinoyl-3, 4-diethoxybenzal hydrazone on murine leprosy.
    Yokohama medical bulletin, 1959, Volume: 10, Issue:2

    Topics: Actinomycetales Infections; Animals; Humans; Hydrazones; Isoniazid; Leprosy; Mice

1959
[On the influence of INH-treatment of rat leprosy on the number of leproma in respect to lowmolecular weight SH-compounds].
    Chemotherapia, 1960, Volume: 1

    Topics: Animals; Isoniazid; Leprosy; Rats

1960
Treatment of reactions in leprosy by aqueous sulphetrone injections and oral INH in a rural centre.
    Leprosy review, 1961, Volume: 32

    Topics: Isoniazid; Leprosy; Rural Population; Sulfones

1961
Effect of several anti-leprosy drugs on multiplication of human leprosy bacilli in footpads of mice.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1962, Volume: 109

    Topics: Aminosalicylic Acid; Animals; Cycloserine; Isoniazid; Leprosy; Mice; Mycobacterium leprae; Sulfones

1962
METABOLIC PATHWAY AND ITS RELATIONSHIP TO THE BIOLOGICAL ACTIVITY OF SOME TUBERCULOSTATIC AND LEPROSTATIC AGENTS.
    Leprosy review, 1964, Volume: 35

    Topics: Antitubercular Agents; Azoles; Drug Resistance; Drug Resistance, Microbial; Humans; Isoniazid; Lepro

1964
TWO UNUSUAL CASES OF NERVE ABSCESS.
    Leprosy review, 1964, Volume: 35

    Topics: Abscess; Humans; Isoniazid; Leprosy; Nerve Tissue; Peripheral Nervous System Diseases; Prednisolone;

1964
[THE CHEMOTHERAPY OF LEPROSY].
    Annales des Societes belges de medecine tropicale, de parasitologie, et de mycologie, 1964, Volume: 44

    Topics: Cycloserine; Dapsone; Drug Therapy; Humans; Isoniazid; Leprosy; Sulfamethoxypyridazine; Sulfones; Th

1964
[Relation between host resistance and disease type in leprosy. 7. Effects of chemotherapy in primary infection on leproma development in superinfection in benign murine leprosy].
    Nihon saikingaku zasshi. Japanese journal of bacteriology, 1962, Volume: 17

    Topics: Actinomycetales Infections; Animals; Communicable Diseases; Humans; Isoniazid; Leprosy; Mice; Superi

1962
Streptomycin and INAH in the treatment of leprosy. A preliminary communication.
    Leprosy review, 1967, Volume: 38, Issue:3

    Topics: Female; Humans; Isoniazid; Leprosy; Male; Streptomycin

1967
Multiple drug therapy--a comparative study with 2 tier and 3 tier combination of rifampicin, clofazimine, DDS, INAH and thiacetazone in lepromatous cases.
    Leprosy in India, 1981, Volume: 53, Issue:2

    Topics: Adolescent; Adult; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Isoniazid

1981
Evaluation of drug regimen in lepromatous leprosy--II.
    Leprosy in India, 1983, Volume: 55, Issue:2

    Topics: Adult; Animals; Clofazimine; Dapsone; Drug Administration Schedule; Drug Resistance, Microbial; Huma

1983
An investigation of dapsone compliance using an isoniazid-marked formulation.
    Leprosy review, 1983, Volume: 54, Issue:4

    Topics: Adolescent; Adult; Aged; Capsules; Creatinine; Dapsone; Drug Combinations; Female; Humans; Isoniazid

1983
Treatment of leprosy using combination therapy--but how?
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1983, Volume: 51, Issue:3

    Topics: Humans; Isoniazid; Leprostatic Agents; Leprosy; Prothionamide

1983
Tuberculosis and its control: lessons to be learned from past experience, and implications for leprosy control programmes.
    Ethiopian medical journal, 1983, Volume: 21, Issue:2

    Topics: Adolescent; Adult; BCG Vaccine; Child; Child, Preschool; Developing Countries; Drug Resistance, Micr

1983
Activity of the combination of isoniazid, protionamide and dapsone against Mycobacterium leprae and some other mycobacteria.
    Arzneimittel-Forschung, 1981, Volume: 31, Issue:12

    Topics: Animals; Dapsone; Drug Interactions; Drug Therapy, Combination; Isoniazid; Isonicotinic Acids; Lepro

1981
Study on drug interactions.
    Leprosy in India, 1980, Volume: 52, Issue:2

    Topics: Adult; Clofazimine; Dapsone; Drug Interactions; Drug Therapy, Combination; Humans; Isoniazid; Lepros

1980
Relapse rates in patients treated with dapsone monotherapy and combinations of dapsone and thiambutosine, thiacetazone, isoniazid and streptomycin in the pre-MDT era.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1994, Volume: 62, Issue:3

    Topics: Dapsone; Drug Therapy, Combination; Female; Humans; Isoniazid; Leprostatic Agents; Leprosy; Male; Ph

1994
Isoniazid and hepatotoxicity.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1993, Volume: 61, Issue:4

    Topics: Female; Humans; Isoniazid; Leprosy; Liver; Pregnancy

1993
Side-effects of Isoprodian compared with WHO-MDT in rural Nepal.
    Leprosy review, 1993, Volume: 64, Issue:3

    Topics: Adolescent; Adult; Aged; Child; Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Human

1993
On the catalase-peroxidase gene, katG, of Mycobacterium leprae and the implications for treatment of leprosy with isoniazid.
    FEMS microbiology letters, 1997, Apr-15, Volume: 149, Issue:2

    Topics: Antitubercular Agents; Bacterial Proteins; Cloning, Molecular; Cosmids; Genes, Bacterial; Isoniazid;

1997
Identification of catalase-like activity from Mycobacterium leprae and the relationship between catalase and isonicotinic acid hydrazide (INH).
    Journal of medical microbiology, 2001, Volume: 50, Issue:8

    Topics: Ammonium Sulfate; Animals; Antitubercular Agents; Bacterial Proteins; Base Sequence; Benzidines; Cat

2001
Controlling the spread of leprosy--some observations on.
    Leprosy in India, 1976, Volume: 48, Issue:3

    Topics: Allied Health Personnel; Antitubercular Agents; Dapsone; Drug Resistance, Microbial; Drug Therapy, C

1976
Metastatic nonsuppurative uveitis.
    International ophthalmology clinics, 1977,Fall, Volume: 17, Issue:3

    Topics: Choroiditis; Endophthalmitis; Humans; Isoniazid; Leprosy; Pigment Epithelium of Eye; Syphilis; Syphi

1977
Leprosy eradication project of Malta. First published report after 5 years running.
    Chemotherapy, 1977, Volume: 23, Issue:5

    Topics: Adolescent; Adult; Aged; Bacteriological Techniques; Child; Dapsone; Drug Therapy, Combination; Fema

1977
In vitro resistance test of human leprosy bacilli to anti-leprous drugs.
    Microbios, 1977, Volume: 19, Issue:76

    Topics: Dapsone; Drug Resistance, Microbial; Humans; Isoniazid; Leprostatic Agents; Leprosy; Microbial Sensi

1977
[Research in the campaign against leprosy (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1977, Sep-02, Volume: 119, Issue:35

    Topics: Animals; Armadillos; Dapsone; Drug Therapy, Combination; Humans; Isoniazid; Leprosy; Mice; Models, B

1977
Combined therapy in leprosy. Background and findings.
    Chemotherapy, 1978, Volume: 24, Issue:3

    Topics: Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Isoniazid; Leprostatic Agents; Lepros

1978
Side effects of clofazimine therapy.
    Leprosy in India, 1976, Volume: 48, Issue:4 Suppl

    Topics: Adolescent; Adult; Clofazimine; Dapsone; Female; Humans; Ichthyosis; Isoniazid; Leprosy; Male; Skin

1976
[New drugs in the treatment of leprosy].
    Medicina cutanea ibero-latino-americana, 1976, Volume: 4, Issue:5

    Topics: Dapsone; Drug Combinations; Drug Evaluation; Humans; Isoniazid; Isonicotinic Acids; Leprosy; Prothio

1976
Preliminary experience with combined therapy using rifampicin and isoprodian (L73A).
    Leprosy review, 1975, Volume: 46, Issue:2 Suppl

    Topics: Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Isoniazid; Isonicotinic Acids; Lepros

1975
Treatment of leprosy with rifampicin and isoprodian in 38 patients at St. Thomas Hospital, Chetput, Sout India.
    Leprosy review, 1975, Volume: 46, Issue:2 Suppl

    Topics: Adolescent; Adult; Child; Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Ind

1975
[Leprosy in Africa. Current status and epidemiological significance].
    Fortschritte der Medizin, 1992, Apr-10, Volume: 110, Issue:10

    Topics: Adolescent; Adult; Africa; Child; Cross-Sectional Studies; Drug Therapy, Combination; Humans; Isonia

1992
[Drugs used in tuberculosis and leprosy].
    Nihon rinsho. Japanese journal of clinical medicine, 1990, Volume: 48, Issue:10

    Topics: Administration, Oral; Antibiotics, Antitubercular; Clofazimine; Dapsone; Humans; Injections, Intramu

1990
Ethionamide, prothionamide and thiacetazone self-administration. Studies of patient compliance using isoniazid-marked formulations.
    Leprosy review, 1986, Volume: 57, Issue:1

    Topics: Adolescent; Adult; Aged; Dapsone; Drug Therapy, Combination; Ethionamide; Female; Humans; Isoniazid;

1986
Isoprodian and rifampicin in the treatment of leprosy: a descriptive evaluation of therapy durations in 475 Paraguayan leprosy patients.
    Chemotherapy, 1989, Volume: 35, Issue:5

    Topics: Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Isoniazid; Isonicotinic Acids; Lepros

1989
New forms of multidrug therapy for the treatment of leprosy. First report for the practice on rifampicin + sulfamethoxazole-trimethoprim + protionamide and rifampicin + sulfamethoxazole-trimethoprim + isoniazid.
    Chemotherapy, 1989, Volume: 35, Issue:2

    Topics: Drug Therapy, Combination; Humans; Isoniazid; Isonicotinic Acids; Leprosy; Prothionamide; Sulfametho

1989
The first joint THELEP-Sasakawa Memorial Health Foundation workshop on experimental chemotherapy of leprosy.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1987, Volume: 55, Issue:4 Suppl

    Topics: Dapsone; Drug Resistance, Microbial; Humans; Isoniazid; Leprosy; Mycobacterium leprae; Mycobacterium

1987
The Malta experience. Isoprodian-rifampicin combination treatment for leprosy.
    Leprosy review, 1986, Volume: 57 Suppl 3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Dapsone; Drug Combinations; Drug Therapy, Combina

1986
First assessment of the Malta Leprosy Eradication Project.
    Leprosy review, 1986, Volume: 57 Suppl 3

    Topics: Dapsone; Drug Combinations; Drug Therapy, Combination; Evaluation Studies as Topic; Follow-Up Studie

1986
Report of the joint leprosy-tuberculosis project in Paraguay.
    Leprosy review, 1986, Volume: 57 Suppl 3

    Topics: Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Isoniazid; Leprostatic Agents; Lepros

1986
The impact of MDT implementation in the Tanzania National TB-Leprosy Programme.
    Leprosy review, 1986, Volume: 57 Suppl 3

    Topics: Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Isoniazid; Isonicotinic Acids

1986
Recent trends in chemotherapy of leprosy.
    The Journal of the Association of Physicians of India, 1985, Volume: 33, Issue:9

    Topics: Clofazimine; Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Isoniazid; Leprostatic A

1985
[Chemotherapy of leprosy].
    Archiv fur klinische und experimentelle Dermatologie, 1970, Volume: 237, Issue:1

    Topics: Dapsone; Female; Humans; Isoniazid; Leprosy; Male; Sulfadiazine; Sulfones; Thioacetazone; Urea; Vita

1970
[Early diagnosis, therapy, and research in the control of leprosy].
    Das Offentliche Gesundheitswesen, 1970, Volume: 32, Issue:12

    Topics: Aniline Compounds; Drug Synergism; Europe; Humans; Hyperbaric Oxygenation; Isoniazid; Leprosy; Phena

1970
Some observations on the pharmacology of clofazimine (B663).
    The American journal of tropical medicine and hygiene, 1974, Volume: 23, Issue:6

    Topics: Aniline Compounds; Animals; Clofazimine; Dose-Response Relationship, Drug; Feces; Humans; Isoniazid;

1974
Dapsone acetylation and the treatment of leprosy.
    Nature, 1972, Sep-15, Volume: 239, Issue:5368

    Topics: Acetates; Dapsone; Humans; Isoniazid; Leprosy

1972
Assessment of the bacteriological effect of combined treatment with rifadin, sulfamethoxypyrazine, and isoniazide in lepromatous leprosy.
    Zeitschrift fur Tropenmedizin und Parasitologie, 1973, Volume: 24

    Topics: Drug Therapy, Combination; Humans; Isoniazid; Leprosy; Microbial Sensitivity Tests; Muscle, Smooth;

1973
Fundamental data, methods and goals of present research on the treatment of leprosy.
    Zeitschrift fur Tropenmedizin und Parasitologie, 1973, Volume: 24

    Topics: Animals; Animals, Laboratory; Antitubercular Agents; Clofazimine; Dapsone; Ethionamide; Humans; In V

1973
A new analogous model for the detection and evaluation of chemotherapeutic products effective in leprosy.
    Arzneimittel-Forschung, 1972, Volume: 22, Issue:8

    Topics: Aniline Compounds; Animals; Dapsone; Disease Models, Animal; Drug Combinations; Ethionamide; Humans;

1972
A pilot study of leprosy treatment with a combination of various antileprosy drugs. Preliminary report.
    Zeitschrift fur Tropenmedizin und Parasitologie, 1973, Volume: 24

    Topics: Adult; Antitubercular Agents; Drug Therapy, Combination; Humans; Isoniazid; Leprosy; Male; Pilot Pro

1973
[Administration of a new antimycobacterial combined therapy in leprosy in East Africa].
    Zeitschrift fur Tropenmedizin und Parasitologie, 1973, Volume: 24

    Topics: Africa, Eastern; Antitubercular Agents; Dapsone; Drug Therapy, Combination; Female; Humans; Isoniazi

1973
The leprosy eradication-project of Malta.
    Zeitschrift fur Tropenmedizin und Parasitologie, 1973, Volume: 24

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Ethionamide; Female; Humans; Infant; Infant, Newbo

1973
A photochromogenic acid-fast bacillus isolated from mouse-leproma.
    Japanese journal of microbiology, 1968, Volume: 12, Issue:1

    Topics: Acid Phosphatase; Amides; Amidohydrolases; Aminosalicylic Acids; Animals; Catalase; Ethambutol; Guin

1968
Antimicrobial activity of the leprostatic drug 3-(p-chloranilino)-10-(p-chlorphenyl-2,10-dihydro-2-(isopropylimino)-phenazine (G 30'320, B. 663).
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:5

    Topics: Animals; Antitubercular Agents; Aspergillosis; Candidiasis; Chloroquine; Cricetinae; Disease Models,

1970
Preliminary test using DMSO as a vehicle for drugs in leprosy.
    Annals of the New York Academy of Sciences, 1967, Mar-15, Volume: 141, Issue:1

    Topics: Aminosalicylic Acids; Dapsone; Dimethyl Sulfoxide; Humans; Isoniazid; Leprosy; Pharmaceutical Vehicl

1967
Dapsone acetylation in man: another example of polymorphic acetylation.
    Annals of the New York Academy of Sciences, 1971, Jul-06, Volume: 179

    Topics: Acetates; Acylation; Adult; Blood Proteins; Dapsone; Female; Fluorometry; Genetics, Medical; Half-Li

1971
Transmission of human leprosy to experimental animals: studies with "Chatterjee" bacilli.
    British journal of experimental pathology, 1965, Volume: 46, Issue:3

    Topics: Animals; Antitubercular Agents; Cornea; Cortisone; Ethambutol; Isoniazid; Leprosy; Liver; Mice; Myco

1965
A histopathological study on the effect of various drugs in experimental murine leprosy. II. On a salivary gland hormone (Parotin) and an unsaturated fatty acid (RTB).
    Acta pathologica japonica, 1969, Volume: 19, Issue:3

    Topics: Animals; Bacteriolysis; Fatty Acids; Granuloma; Histiocytes; Hormones; Isoniazid; Leprosy; Mice; Pha

1969
Treatment of leprosy with a combination of injectable thiambutosine (CIBA 1906), streptomycin and isoniazid.
    Leprosy review, 1966, Volume: 37, Issue:1

    Topics: Africa, Southern; Humans; Isoniazid; Leprosy; Streptomycin; Thiourea

1966
[Rapid action of isoniazid in a case of reactional leprosy].
    Bulletin de la Societe francaise de dermatologie et de syphiligraphie, 1966, Volume: 73, Issue:6

    Topics: Humans; Isoniazid; Leprosy; Male

1966