isoniazid and Hypoxia
isoniazid has been researched along with Hypoxia in 16 studies
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Based on a 2 × 2 full factorial design consisting of two factors of chronic intermittent hypoxia and isoniazid plus rifampicin, 32 male C57B6J mice were randomized into the control group, the chronic intermittent hypoxia group, the isoniazid plus rifampicin group, and the chronic intermittent hypoxia + isoniazid plus rifampicin group." | 7.77 | Intermittent hypoxia and isoniazid plus rifampicin affect hepatic ultrastructure in mice. ( Chen, XY; Wu, RH; Zeng, YM, 2011) |
| "Experiments in rats with different sensitivity to hypobaric hypoxia established bimodal distribution of antipyrine and isoniazide half-lives." | 7.68 | [The effect of acute hypoxia on antipyrine and isoniazid pharmacokinetics in rats with different resistances to oxygen deficiency]. ( Grek, OR; Kolpakov, MA; Sharapov, VI, 1993) |
| "Treatment of persons with latent tuberculosis (TB) infection at greatest risk of reactivation is an important component of TB control and elimination strategies." | 6.80 | Effect of isoniazid on antigen-specific interferon-γ secretion in latent tuberculosis. ( Canizales, S; Carranza, C; Cruz-Hervert, P; Delgado-Sánchez, G; Ferreira-Guerrero, E; Ferreyra-Reyes, L; García-García, L; Guio, H; Molina, S; Mongua-Rodriguez, N; Montero-Campos, R; Ponce-de Leon, A; Sada, E; Sifuentes-Osornio, J; Téllez, N; Torres, M; Wilkinson, RJ; Young, DB, 2015) |
| "Based on a 2 × 2 full factorial design consisting of two factors of chronic intermittent hypoxia and isoniazid plus rifampicin, 32 male C57B6J mice were randomized into the control group, the chronic intermittent hypoxia group, the isoniazid plus rifampicin group, and the chronic intermittent hypoxia + isoniazid plus rifampicin group." | 3.77 | Intermittent hypoxia and isoniazid plus rifampicin affect hepatic ultrastructure in mice. ( Chen, XY; Wu, RH; Zeng, YM, 2011) |
| "Experiments in rats with different sensitivity to hypobaric hypoxia established bimodal distribution of antipyrine and isoniazide half-lives." | 3.68 | [The effect of acute hypoxia on antipyrine and isoniazid pharmacokinetics in rats with different resistances to oxygen deficiency]. ( Grek, OR; Kolpakov, MA; Sharapov, VI, 1993) |
| "Treatment of persons with latent tuberculosis (TB) infection at greatest risk of reactivation is an important component of TB control and elimination strategies." | 2.80 | Effect of isoniazid on antigen-specific interferon-γ secretion in latent tuberculosis. ( Canizales, S; Carranza, C; Cruz-Hervert, P; Delgado-Sánchez, G; Ferreira-Guerrero, E; Ferreyra-Reyes, L; García-García, L; Guio, H; Molina, S; Mongua-Rodriguez, N; Montero-Campos, R; Ponce-de Leon, A; Sada, E; Sifuentes-Osornio, J; Téllez, N; Torres, M; Wilkinson, RJ; Young, DB, 2015) |
| "tuberculosis have striking similarities, such as necrosis, mineralization, and hypoxia, to natural infections in humans." | 1.34 | Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910. ( Aly, S; Andries, K; Basaraba, RJ; Cantarero, L; Ehlers, S; Hoff, D; Lenaerts, AJ; Orme, IM, 2007) |
Research
Studies (16)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (37.50) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 5 (31.25) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Gupta, RK | 1 |
| Thakur, TS | 1 |
| Desiraju, GR | 1 |
| Tyagi, JS | 1 |
| Fan, X | 1 |
| Ren, T | 1 |
| Yang, W | 1 |
| Zhang, X | 1 |
| Yuan, L | 1 |
| Gengenbacher, M | 1 |
| Duque-Correa, MA | 1 |
| Kaiser, P | 1 |
| Schuerer, S | 1 |
| Lazar, D | 1 |
| Zedler, U | 1 |
| Reece, ST | 1 |
| Nayyar, A | 1 |
| Cole, ST | 1 |
| Makarov, V | 1 |
| Barry Iii, CE | 1 |
| Dartois, V | 1 |
| Kaufmann, SHE | 1 |
| Iacobino, A | 1 |
| Giannoni, F | 1 |
| Pardini, M | 1 |
| Piccaro, G | 1 |
| Fattorini, L | 1 |
| Sukumar, N | 1 |
| Tan, S | 1 |
| Aldridge, BB | 1 |
| Russell, DG | 1 |
| Torres, M | 1 |
| García-García, L | 1 |
| Cruz-Hervert, P | 1 |
| Guio, H | 1 |
| Carranza, C | 1 |
| Ferreyra-Reyes, L | 1 |
| Canizales, S | 1 |
| Molina, S | 1 |
| Ferreira-Guerrero, E | 1 |
| Téllez, N | 1 |
| Montero-Campos, R | 1 |
| Delgado-Sánchez, G | 1 |
| Mongua-Rodriguez, N | 1 |
| Sifuentes-Osornio, J | 1 |
| Ponce-de Leon, A | 1 |
| Sada, E | 1 |
| Young, DB | 1 |
| Wilkinson, RJ | 1 |
| Wu, RH | 1 |
| Zeng, YM | 1 |
| Chen, XY | 1 |
| Balazuc, AM | 1 |
| Lagranderie, M | 1 |
| Chavarot, P | 1 |
| Pescher, P | 1 |
| Roseeuw, E | 1 |
| Schacht, E | 1 |
| Domurado, D | 1 |
| Marchal, G | 1 |
| Lenaerts, AJ | 1 |
| Hoff, D | 1 |
| Aly, S | 1 |
| Ehlers, S | 1 |
| Andries, K | 1 |
| Cantarero, L | 1 |
| Orme, IM | 1 |
| Basaraba, RJ | 1 |
| Sharapov, VI | 1 |
| Kolpakov, MA | 1 |
| Grek, OR | 1 |
| Taboada Lopez, G | 1 |
| Navarro de Claure, ML | 1 |
| Aleksandrova, AE | 1 |
| Boldina, IG | 1 |
| Boldysheva, AV | 1 |
| Shchegoleva, RA | 1 |
| Wood, JD | 1 |
| Peesker, SJ | 1 |
| LaMont, JT | 1 |
| Mustala, OO | 1 |
| Azarnoff, DL | 1 |
| Ramirez, J | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Drugs for Treatment of Latent Tuberculosis Infection Objective 4: Identify Biomarkers for Clinical Trials of Drugs Active Against Latent TB[NCT00293228] | Phase 4 | 200 participants (Anticipated) | Interventional | 2007-02-28 | Completed | ||
| Efficacy, Security, Adherence, Tolerability and Cost Effectiveness of Latent TB Treatment in Patients With TB/DM2[NCT03278483] | Phase 4 | 396 participants (Actual) | Interventional | 2019-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
1 review available for isoniazid and Hypoxia
| Article | Year |
|---|---|
Postoperative juandice.
Topics: Aminosalicylic Acids; Anemia, Hemolytic; Bile Ducts; Bilirubin; Chemical and Drug Induced Liver Inju | 1974 |
Trials
1 trial available for isoniazid and Hypoxia
| Article | Year |
|---|---|
Effect of isoniazid on antigen-specific interferon-γ secretion in latent tuberculosis.
Topics: Adolescent; Adult; Antigens, Bacterial; Bacterial Proteins; Biomarkers; Female; Humans; Hypoxia; Int | 2015 |
Effect of isoniazid on antigen-specific interferon-γ secretion in latent tuberculosis.
Topics: Adolescent; Adult; Antigens, Bacterial; Bacterial Proteins; Biomarkers; Female; Humans; Hypoxia; Int | 2015 |
Effect of isoniazid on antigen-specific interferon-γ secretion in latent tuberculosis.
Topics: Adolescent; Adult; Antigens, Bacterial; Bacterial Proteins; Biomarkers; Female; Humans; Hypoxia; Int | 2015 |
Effect of isoniazid on antigen-specific interferon-γ secretion in latent tuberculosis.
Topics: Adolescent; Adult; Antigens, Bacterial; Bacterial Proteins; Biomarkers; Female; Humans; Hypoxia; Int | 2015 |
Other Studies
14 other studies available for isoniazid and Hypoxia
| Article | Year |
|---|---|
Structure-based design of DevR inhibitor active against nonreplicating Mycobacterium tuberculosis.
Topics: Aerobiosis; Antitubercular Agents; Bacterial Proteins; Binding Sites; Computational Biology; DNA, Ba | 2009 |
Activatable photoacoustic/fluorescent dual-modal probe for monitoring of drug-induced liver hypoxia in vivo.
Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Fluorescent Dyes; Hypoxia; Isoniazid; Liver | 2021 |
NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans.
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Fibrosis; Foam Cells; Humans; Hypoxia; Isoni | 2017 |
The Combination Rifampin-Nitazoxanide, but Not Rifampin-Isoniazid-Pyrazinamide-Ethambutol, Kills Dormant Mycobacterium tuberculosis in Hypoxia at Neutral pH.
Topics: Antitubercular Agents; Drug Combinations; Drug Therapy, Combination; Ethambutol; Humans; Hydrogen-Io | 2019 |
Exploitation of Mycobacterium tuberculosis reporter strains to probe the impact of vaccination at sites of infection.
Topics: Animals; Antitubercular Agents; Fluorescent Antibody Technique; Genes, Reporter; Host-Pathogen Inter | 2014 |
Intermittent hypoxia and isoniazid plus rifampicin affect hepatic ultrastructure in mice.
Topics: Animals; Hypoxia; Isoniazid; Liver; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmissi | 2011 |
In vivo efficiency of targeted norfloxacin against persistent, isoniazid-insensitive, Mycobacterium bovis BCG present in the physiologically hypoxic mouse liver.
Topics: Animals; Antitubercular Agents; Drug Design; Drug Resistance, Bacterial; Female; Hypoxia; Isoniazid; | 2005 |
Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910.
Topics: Animals; Antibiotics, Antitubercular; Antitubercular Agents; Colony Count, Microbial; Diarylquinolin | 2007 |
[The effect of acute hypoxia on antipyrine and isoniazid pharmacokinetics in rats with different resistances to oxygen deficiency].
Topics: Acute Disease; Animals; Antipyrine; Atmosphere Exposure Chambers; Disease Susceptibility; Half-Life; | 1993 |
[Isoniazid acetylation, its relation to genetic and environmental altitude factors].
Topics: Acetylation; Adolescent; Adult; Aged; Altitude; Antitubercular Agents; Arylamine N-Acetyltransferase | 1987 |
[Effectiveness of the combined use of antihypoxic agents and antioxidants in tuberculosis].
Topics: Animals; Antioxidants; Butylated Hydroxytoluene; Hydroxybutyrates; Hypoxia; Isoniazid; Lipid Peroxid | 1988 |
The effect of hypoxia on isonicotinic acid hydrazide-induced seizures in chicks during ontogenesis.
Topics: Age Factors; Aminobutyrates; Animals; Brain; Brain Chemistry; Chickens; Hypoxia; Isoniazid; Male; Se | 1971 |
Effect of oxygen tension on drug levels and pharmacological action in the intact animal.
Topics: Animals; Barbiturates; Brain Chemistry; Hexobarbital; Hyperbaric Oxygenation; Hypoxia; Isoniazid; Ma | 1969 |
Alveolar proteinosis: importance of pulmonary lavage.
Topics: Acetylcysteine; Adult; Aerosols; Heparin; Humans; Hypoxia; Isoniazid; L-Lactate Dehydrogenase; Male; | 1971 |