isoniazid has been researched along with Huntington Disease in 22 studies
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seven patients with Huntington disease were treated with aminooxyacetic acid (AOAA), an inhibitor of gamma-aminobutyric acid aminotransferase (GABA-T), in an effort to alleviate symptoms by increasing brain GABA content." | 9.05 | Failure of aminooxyacetic acid therapy in Huntington disease. ( Allan, BM; Baird, PA; Hansen, S; MacLeod, PM; Perry, TL; Wright, JM, 1980) |
| "Isoniazid (INH) was given to nine patients with Huntington disease (HD) in a double-blind, placebo-controlled crossover trial." | 9.05 | A double-blind clinical trial of isoniazid in Huntington disease. ( Allan, BM; Baird, PA; Diewold, PA; Hansen, S; Perry, TL; Thomas, SM; Wright, JM, 1982) |
| "We describe clinical and biochemical changes in seven patients with Huntington disease given isoniazid (INH) in dosages three to five greater than normally used in tuberculosis." | 9.04 | Isoniazid therapy of Huntington disease. ( Hansen, S; MacLeod, PM; Perry, TL; Wright, JM, 1979) |
| "Seven patients with Huntington disease were treated with aminooxyacetic acid (AOAA), an inhibitor of gamma-aminobutyric acid aminotransferase (GABA-T), in an effort to alleviate symptoms by increasing brain GABA content." | 5.05 | Failure of aminooxyacetic acid therapy in Huntington disease. ( Allan, BM; Baird, PA; Hansen, S; MacLeod, PM; Perry, TL; Wright, JM, 1980) |
| "Isoniazid (INH) was given to nine patients with Huntington disease (HD) in a double-blind, placebo-controlled crossover trial." | 5.05 | A double-blind clinical trial of isoniazid in Huntington disease. ( Allan, BM; Baird, PA; Diewold, PA; Hansen, S; Perry, TL; Thomas, SM; Wright, JM, 1982) |
| "We describe clinical and biochemical changes in seven patients with Huntington disease given isoniazid (INH) in dosages three to five greater than normally used in tuberculosis." | 5.04 | Isoniazid therapy of Huntington disease. ( Hansen, S; MacLeod, PM; Perry, TL; Wright, JM, 1979) |
| "Treatment with isoniazid had no significant effect on CSF choline levels or CSF AChE activity." | 2.67 | Cerebrospinal fluid acetylcholinesterase and choline measurements in Huntington's disease. ( Colliver, JA; Giacobini, E; Manyam, BV, 1990) |
| "Eleven patients with Huntington's disease were treated with high doses of isoniazid." | 1.27 | Quantitative evaluation of functional capacity during isoniazid therapy in Huntington's disease. ( Holzer, G; Schimrigk, K; Stober, T; Ziegler, B, 1983) |
| "gamma-Aminobutyric acid (GABA) was measured in CSF as such and following acid hydrolysis by the ion-exchange/fluorometric method." | 1.27 | Free and conjugated GABA in human cerebrospinal fluid: effect of degenerative neurologic diseases and isoniazid. ( Manyam, BV; Tremblay, RD, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (95.45) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stober, T | 1 |
| Schimrigk, K | 1 |
| Holzer, G | 1 |
| Ziegler, B | 1 |
| Yamamoto, M | 1 |
| Otsuki, S | 1 |
| Miyake, K | 1 |
| Namba, R | 1 |
| McLean, DR | 1 |
| Manyam, BV | 4 |
| Tremblay, RD | 2 |
| Perry, TL | 9 |
| Ito, M | 1 |
| Jones, K | 1 |
| Hansen, S | 8 |
| Manyam, NV | 1 |
| Hare, TA | 3 |
| Katz, L | 2 |
| Wright, JM | 3 |
| Allan, BM | 2 |
| Baird, PA | 2 |
| MacLeod, PM | 3 |
| Schneider, G | 1 |
| Oepen, H | 1 |
| Klapproth, A | 1 |
| Kaniefski, K | 1 |
| Braham, J | 1 |
| Marsden, CD | 1 |
| Sheehy, MP | 1 |
| Thomas, SM | 1 |
| Diewold, PA | 1 |
| Roccatagliata, G | 1 |
| Albano, C | 1 |
| Smith, DB | 1 |
| Giacobini, E | 1 |
| Colliver, JA | 1 |
| Ferraro, TN | 1 |
| Wall, RA | 1 |
| Urquhart, N | 1 |
| Kennedy, J | 1 |
9 trials available for isoniazid and Huntington Disease
| Article | Year |
|---|---|
Failure of isoniazid therapy in Huntington disease.
Topics: Adult; Brain; Double-Blind Method; gamma-Aminobutyric Acid; Humans; Huntington Disease; Isoniazid; M | 1982 |
Effect of isoniazid on cerebrospinal fluid and plasma GABA levels in Huntington's disease.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; gamma-Aminobutyric Acid; Humans; Huntington Di | 1980 |
Failure of aminooxyacetic acid therapy in Huntington disease.
Topics: Acetates; Adult; Amino Acids; Aminooxyacetic Acid; Double-Blind Method; Female; Humans; Huntington D | 1980 |
Isoniazid-induced elevation of CSF GABA levels and effects on chorea in Huntington's disease.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; gamma-Aminobutyric Acid; Humans; Huntington Di | 1981 |
GABA and movement disorders.
Topics: Anticonvulsants; Baclofen; Clinical Trials as Topic; Double-Blind Method; Dyskinesia, Drug-Induced; | 1981 |
A double-blind clinical trial of isoniazid in Huntington disease.
Topics: Adult; Aged; Amino Acids; Ataxia; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hun | 1982 |
Isoniazid therapy of Huntington disease.
Topics: 4-Aminobutyrate Transaminase; Adult; Brain; Clinical Trials as Topic; Female; gamma-Aminobutyric Aci | 1979 |
Cerebrospinal fluid acetylcholinesterase and choline measurements in Huntington's disease.
Topics: Acetylcholinesterase; Adult; Aged; Aged, 80 and over; Analysis of Variance; Choline; Double-Blind Me | 1990 |
Isoniazid-induced alteration of CSF neurotransmitter amino acids in Huntington's disease.
Topics: Adult; Amino Acids; Clinical Trials as Topic; Double-Blind Method; gamma-Aminobutyric Acid; Histidin | 1987 |
13 other studies available for isoniazid and Huntington Disease
| Article | Year |
|---|---|
Quantitative evaluation of functional capacity during isoniazid therapy in Huntington's disease.
Topics: Adult; Disability Evaluation; Female; Humans; Huntington Disease; Isoniazid; Male; Mental Disorders; | 1983 |
[Lumbar cerebrospinal fluid levels of GABA, HVA and 5HIAA in various patients with choreic movement and effects with isoniazid treatment].
Topics: Acanthocytes; Adult; Aged; Atrophy; Brain Diseases; Chorea; gamma-Aminobutyric Acid; Homovanillic Ac | 1983 |
Free and conjugated GABA in human cerebrospinal fluid: effect of degenerative neurologic diseases and isoniazid.
Topics: Adult; Age Factors; Aged; Cerebellar Ataxia; Dementia; Epilepsy; gamma-Aminobutyric Acid; Humans; Hu | 1984 |
Elevation of gamma-aminobutyric acid in human brain may increase dopaminergic neuronal function.
Topics: Brain; Brain Chemistry; Dopamine; gamma-Aminobutyric Acid; Homovanillic Acid; Humans; Huntington Dis | 1984 |
[Symptomatic therapy in a possible animal model for Huntington's chorea].
Topics: Animals; Bromocriptine; Disease Models, Animal; Glucosamine; Huntington Disease; Isoniazid; Male; Ni | 1981 |
Isoniazid therapy for Huntington disease.
Topics: Humans; Huntington Disease; Isoniazid; Middle Aged | 1981 |
Treatment of Huntington's chorea with isoniazid.
Topics: 4-Aminobutyrate Transaminase; Humans; Huntington Disease; Isoniazid | 1977 |
Isoniazid and Huntington's chorea.
Topics: Drug Therapy, Combination; Humans; Huntington Disease; Isoniazid; Pyridoxine | 1978 |
Isoniazid and Huntington's chorea.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Humans; Huntington Disease; Isoniazid; Rats; Valproic Acid | 1978 |
Biochemical effects in man and rat of three drugs which can increase brain GABA content.
Topics: Acetates; Adult; Amino Acids; Aminobutyrates; Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyri | 1978 |
INH therapy: benefits versus risks.
Topics: Humans; Huntington Disease; Isoniazid; Risk | 1979 |
Brain amino compounds in a Huntington's disease patient on isoniazid therapy.
Topics: Adult; Brain Chemistry; Carnosine; Caudate Nucleus; Cerebellar Nuclei; gamma-Aminobutyric Acid; Huma | 1985 |
Gamma-aminobutyric acid: drug-induced elevation in monkey brain.
Topics: Acetates; Aminobutyrates; Animals; Brain; Carbon Radioisotopes; Carboxy-Lyases; gamma-Aminobutyric A | 1974 |