Page last updated: 2024-10-29

isoniazid and Hepatitis

isoniazid has been researched along with Hepatitis in 44 studies

Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).

Hepatitis: INFLAMMATION of the LIVER.

Research Excerpts

ExcerptRelevanceReference
"Hepatotoxicity associated with isoniazid preventive therapy (IPT) and antiretroviral therapy (ART) has not been well studied in severely immunosuppressed people with HIV."9.27Hepatotoxicity During Isoniazid Preventive Therapy and Antiretroviral Therapy in People Living With HIV With Severe Immunosuppression: A Secondary Analysis of a Multi-Country Open-Label Randomized Controlled Clinical Trial. ( Bisson, GP; Gupta, A; Hosseinipour, MC; Hughes, MD; Kidonge, KK; Kumwenda, J; Lavenberg, JA; Miyahara, S; Ngongondo, M; Nyirenda, M; Sun, X; Torres, TS, 2018)
"To investigate associations between isoniazid for latent tuberculosis and risk of severe hepatitis, affecting patients with rheumatoid arthritis or ankylosing spondylitis whose treatment includes tumor necrosis factor inhibitors."8.02Association between 9-month isoniazid prophylaxis of latent tuberculosis and severe hepatitis in patients treated with TNF inhibitors. ( Chao, PH; Chen, WW; Huang, WI; Huang, YC; Lai, EC; Liang, HY; Weng, MY, 2021)
"To investigate the clinical characteristics, adverse drug reactions, and outcomes of the oldest old patients (aged ≥80 years) with tuberculosis (TB) treated with rifampicin, isoniazid, and pyrazinamide (RIP)-containing regimens."7.83The clinical outcomes of oldest old patients with tuberculosis treated by regimens containing rifampicin, isoniazid, and pyrazinamide. ( Chang, PJ; Cheng, CW; Chou, YL; Lin, HS; Lin, JC; Lin, MS; Ye, JJ, 2016)
"Hepatotoxicity associated with isoniazid preventive therapy (IPT) and antiretroviral therapy (ART) has not been well studied in severely immunosuppressed people with HIV."5.27Hepatotoxicity During Isoniazid Preventive Therapy and Antiretroviral Therapy in People Living With HIV With Severe Immunosuppression: A Secondary Analysis of a Multi-Country Open-Label Randomized Controlled Clinical Trial. ( Bisson, GP; Gupta, A; Hosseinipour, MC; Hughes, MD; Kidonge, KK; Kumwenda, J; Lavenberg, JA; Miyahara, S; Ngongondo, M; Nyirenda, M; Sun, X; Torres, TS, 2018)
"To investigate associations between isoniazid for latent tuberculosis and risk of severe hepatitis, affecting patients with rheumatoid arthritis or ankylosing spondylitis whose treatment includes tumor necrosis factor inhibitors."4.02Association between 9-month isoniazid prophylaxis of latent tuberculosis and severe hepatitis in patients treated with TNF inhibitors. ( Chao, PH; Chen, WW; Huang, WI; Huang, YC; Lai, EC; Liang, HY; Weng, MY, 2021)
" The secondary objective was to determine the overall incidence of hepatitis in children on Anti tubercular treatment (ATT) and isoniazid prophylactic therapy (IPT)."3.91Revised Antituberculosis Drug Doses and Hepatotoxicity in HIV Negative Children. ( Indumathi, CK; Jain, S; Krishnamurthy, S; Sethuraman, A, 2019)
"To investigate the clinical characteristics, adverse drug reactions, and outcomes of the oldest old patients (aged ≥80 years) with tuberculosis (TB) treated with rifampicin, isoniazid, and pyrazinamide (RIP)-containing regimens."3.83The clinical outcomes of oldest old patients with tuberculosis treated by regimens containing rifampicin, isoniazid, and pyrazinamide. ( Chang, PJ; Cheng, CW; Chou, YL; Lin, HS; Lin, JC; Lin, MS; Ye, JJ, 2016)
"We prospectively examined the incidence of drug-induced hepatitis in 2070 patients treated for TB with the standard regimen based on 6 months of rifampicin (R, RMP) and isoniazid (H, INH), with 2 months of initial pyrazinamide (Z, PZA) and ethambutol (E, EMB), over a 30-year period from 1981 to 2010, in Blackburn, UK."3.83Drug-related hepatitis in patients treated with standard anti-tuberculosis chemotherapy over a 30-year period. ( Bright-Thomas, RJ; Gondker, AR; Morris, J; Ormerod, LP, 2016)
"Using the on-chip activity assay, hepatocellular carcinoma patients (n = 24), but not hepatitis (n = 24) or liver cirrhosis patients (n = 41), had significantly lower FXIII activities (p < 0."1.37Rapid determination of blood coagulation factor XIII activity using protein arrays for serodiagnosis of human plasma. ( Ha, KS; Jung, SH; Kim, YM; Kong, DH; Kwon, MH; Suh, IB, 2011)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-199032 (72.73)18.7374
1990's1 (2.27)18.2507
2000's1 (2.27)29.6817
2010's8 (18.18)24.3611
2020's2 (4.55)2.80

Authors

AuthorsStudies
Lai, EC1
Liang, HY1
Huang, YC1
Huang, WI1
Chao, PH1
Chen, WW1
Weng, MY1
Kristensen, KL1
Nordholm, AC1
Clausen, MR1
Katzenstein, TL1
Ngongondo, M1
Miyahara, S1
Hughes, MD1
Sun, X1
Bisson, GP1
Gupta, A1
Kumwenda, J1
Lavenberg, JA1
Torres, TS1
Nyirenda, M1
Kidonge, KK1
Hosseinipour, MC1
Indumathi, CK1
Sethuraman, A1
Jain, S1
Krishnamurthy, S1
Dobler, CC1
Martin, A1
Marks, GB1
Lin, HS1
Cheng, CW1
Lin, MS1
Chou, YL1
Chang, PJ1
Lin, JC1
Ye, JJ1
Bright-Thomas, RJ1
Gondker, AR1
Morris, J1
Ormerod, LP1
Whritenour, J1
Ko, M1
Zong, Q1
Wang, J1
Tartaro, K1
Schneider, P1
Olson, E1
Van Volkenburg, M1
Serrano, J1
Hayashi, P1
Fontana, R1
Chalasani, N1
Bonkovsky, HL1
Vieira, FJ1
Callado, MR1
Vieira, WP1
Kwon, MH1
Kong, DH1
Jung, SH1
Suh, IB1
Kim, YM1
Ha, KS1
RANDOLPH, H1
JOSEPH, S1
GELLIS, SN1
MURPHY, RV1
DANIELLO, L1
COSMA, V1
MOISESCU, V1
PAPILLIAN, VV1
JOSAN, R1
MERRITT, AD1
FETTER, BF1
GILLIS, S1
TEXLER, K1
LUSZCZEWSKA-TOMASZEWSKA, D1
KOLOSOWSKA, J1
MERGEL-MADEY, B1
BEK, E1
BOWER, G1
UTKIN, VV1
OLEKHNOVICH, LI1
COTTIN, S1
COZAN, R1
VERAN, P1
CISZEK, J1
ENTZ, A1
RODGERS, JB1
MALLORY, GK1
DAVIDSON, DS1
CONN, HO1
BINDER, HJ1
ORR, HD1
LUDWIG, H1
EWALD, W1
ROKA, L1
WOROBEC, T1
SITZMANN, FC1
Van Outryve, SM1
Francque, SM1
Gentens, PA1
De Pauw, FF1
Van den Bogaert, E1
Van Marck, EA1
Pelckmans, PA1
Michielsen, PP1
Angel, JH1
Schaberg, T1
Rebhan, K1
Lode, H1
Ziegler, HK1
Sinazadeh, M1
Oldershausen v, HF1
Maddrey, WC1
Boitnott, JK1
Heissmeyer, HH1
Neumann, TG1
Craig, RM1
Poticha, S1
Levi, AJ1
Sherlock, S1
Walker, D1
Maas, D1
Merlin, D1
vest, M1
Just, M1
Bianchi, L1
Tournier, G1
Grunberg, J1
Hanoteau, J1
Gerbeaux, J1
Simon, HB2
Wolff, SM2
Francis, TI1
Seki, S1

Reviews

4 reviews available for isoniazid and Hepatitis

ArticleYear
Bacillus Calmette-Guérin-induced granulomatous hepatitis in a patient with a superficial bladder carcinoma.
    European journal of gastroenterology & hepatology, 2004, Volume: 16, Issue:10

    Topics: Adjuvants, Immunologic; Administration, Intravesical; Aged; Antitubercular Agents; BCG Vaccine; Biop

2004
[Hepatitis-like liver disorders caused by infections, poisoning and drugs].
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1976, Volume: 82 Pt 1

    Topics: Alcoholism; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Cytomegalovirus Infection

1976
Drug-induced chronic hepatitis and cirrhosis.
    Progress in liver diseases, 1979, Volume: 6

    Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adve

1979
[Antinuclear factors. Demonstration and clinico-diagnostic significance].
    Medizinische Klinik, 1969, Jul-18, Volume: 64, Issue:29

    Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Chronic Disease

1969

Trials

3 trials available for isoniazid and Hepatitis

ArticleYear
Hepatotoxicity During Isoniazid Preventive Therapy and Antiretroviral Therapy in People Living With HIV With Severe Immunosuppression: A Secondary Analysis of a Multi-Country Open-Label Randomized Controlled Clinical Trial.
    Journal of acquired immune deficiency syndromes (1999), 2018, 05-01, Volume: 78, Issue:1

    Topics: Adult; Alanine Transaminase; Anti-Retroviral Agents; Antitubercular Agents; Aspartate Aminotransfera

2018
BTA short-course chemotherapy studies.
    Chest, 1981, Volume: 80, Issue:6

    Topics: Clinical Trials as Topic; Ethambutol; Female; Hepatitis; Humans; Isoniazid; Liver Function Tests; Ma

1981
Phenylbutazone and isoniazid metabolism in patients with liver disease in relation to previous drug therapy.
    Lancet (London, England), 1968, Jun-15, Volume: 1, Issue:7555

    Topics: Acetylesterase; Acute Disease; Alcoholism; Alkaline Phosphatase; Aspartate Aminotransferases; Barbit

1968

Other Studies

37 other studies available for isoniazid and Hepatitis

ArticleYear
Association between 9-month isoniazid prophylaxis of latent tuberculosis and severe hepatitis in patients treated with TNF inhibitors.
    Scientific reports, 2021, 09-09, Volume: 11, Issue:1

    Topics: Adult; Aged; Antitubercular Agents; Arthritis, Rheumatoid; Female; Hepatitis; Hospitalization; Human

2021
[Isoniazid-inducedtoxic hepatitis].
    Ugeskrift for laeger, 2021, 02-08, Volume: 183, Issue:6

    Topics: Adult; Antitubercular Agents; Hepatitis; Humans; Isoniazid; Latent Tuberculosis; Male

2021
Revised Antituberculosis Drug Doses and Hepatotoxicity in HIV Negative Children.
    Indian journal of pediatrics, 2019, Volume: 86, Issue:3

    Topics: Adolescent; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Child; Child, Preschool;

2019
Benefit of treatment of latent tuberculosis infection in individual patients.
    The European respiratory journal, 2015, Volume: 46, Issue:5

    Topics: Adolescent; Adult; Aged; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Child; Femal

2015
The clinical outcomes of oldest old patients with tuberculosis treated by regimens containing rifampicin, isoniazid, and pyrazinamide.
    Clinical interventions in aging, 2016, Volume: 11

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antitubercular Agents; Chemical and Drug Induced Liver I

2016
Drug-related hepatitis in patients treated with standard anti-tuberculosis chemotherapy over a 30-year period.
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2016, Volume: 20, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antitubercular Agents; Chemical and Drug Induced Liver I

2016
Development of a modified lymphocyte transformation test for diagnosing drug-induced liver injury associated with an adaptive immune response.
    Journal of immunotoxicology, 2017, Volume: 14, Issue:1

    Topics: Acute Disease; Adaptive Immunity; Cell Proliferation; Cells, Cultured; Chemical and Drug Induced Liv

2017
Abatacept as an option therapy in difficult to treat psoriatic arthritis.
    Rheumatology international, 2010, Volume: 30, Issue:6

    Topics: Abatacept; Arthritis, Psoriatic; Drug Administration Schedule; Drug Resistance; Female; Hepatitis; H

2010
Rapid determination of blood coagulation factor XIII activity using protein arrays for serodiagnosis of human plasma.
    Analytical chemistry, 2011, Mar-15, Volume: 83, Issue:6

    Topics: Amines; Biomarkers, Tumor; Biotin; Blood Specimen Collection; Carcinoma, Hepatocellular; Factor XIII

2011
Toxic hepatitis with jaundice occuring in a patient treated with isoniazid.
    Journal of the American Medical Association, 1953, May-02, Volume: 152, Issue:1

    Topics: Chemical and Drug Induced Liver Injury; Hepatitis; Hepatitis A; Isoniazid; Jaundice; Niacin; Nicotin

1953
Hepatitis following isoniazid.
    Diseases of the chest, 1955, Volume: 28, Issue:4

    Topics: Hepatitis; Hepatitis A; Isoniazid; Jaundice; Niacin; Nicotinic Acids; Tuberculosis; Tuberculosis, Pu

1955
[Notes on toxic hepatitis during hydrazide therapy].
    Medicina interna, 1957, Volume: 9, Issue:2

    Topics: Chemical and Drug Induced Liver Injury; Hepatitis; Hepatitis A; Humans; Isoniazid

1957
Toxic hepatic necrosis (hepatitis) due to isoniazid: report of a case with cirrhosis and death due to hemorrhage from esophageal varices.
    Annals of internal medicine, 1959, Volume: 50, Issue:3

    Topics: Esophageal and Gastric Varices; Esophagus; Hemorrhage; Hepatitis; Hepatitis A; Isoniazid; Liver Cirr

1959
Unusual reactions to anti-tuberculous chemotherapy.
    The Medical journal of Australia, 1960, Jul-16, Volume: 47(2)

    Topics: Hepatitis; Hepatitis A; Humans; Isoniazid; Pyrazinamide; Tuberculosis; Uric Acid

1960
[A CASE OF AN UNUSUALLY SEVERE SENSITIZATION TO ANTIBACTERIAL DRUGS].
    Gruzlica (Warsaw, Poland : 1926), 1963, Volume: 31

    Topics: Adolescent; Adrenal Cortex Hormones; Aminosalicylic Acid; Aminosalicylic Acids; Anti-Bacterial Agent

1963
[INTOLERANCE AND TOXICITY OF SUBSTITUTE ANTIBACTERIAL DRUGS].
    Gruzlica (Warsaw, Poland : 1926), 1963, Volume: 31

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Anti-Bacterial Agents; Chemical and Drug Induced Liver In

1963
SKIN RASH, HEPATITIS, AND HEMOLYTIC ANEMIA CAUSED BY PARA-AMINOSALICYLIC ACID.
    The American review of respiratory disease, 1964, Volume: 89

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Anemia; Anemia, Hemolytic; Chemical and Drug Induced Live

1964
[TOXIC EFFECT OF CYCLOSERINE].
    Problemy tuberkuleza, 1963, Volume: 41

    Topics: Alanine Transaminase; Aminosalicylic Acid; Aminosalicylic Acids; Aspartate Aminotransferases; Centra

1963
[MORPHOLOGICAL CHANGES IN THE INTERNAL ORGANS OF INTACT ANIMALS IN PROLONGED ADMINISTRATION OF PHTHIVAZID].
    Problemy tuberkuleza, 1963, Volume: 41

    Topics: Amyloidosis; Chemical and Drug Induced Liver Injury; Hepatitis; Hepatitis A; Hyperemia; Isoniazid; M

1963
[APROPOS OF ETHIONAMIDE JAUNDICE].
    Le Poumon et le coeur, 1964, Volume: 20

    Topics: Alanine Transaminase; Alcoholism; Aminosalicylic Acid; Aminosalicylic Acids; Aspartate Aminotransfer

1964
[SENSITIZATION TO ANTIBACTERIAL DRUGS WITH SPECIAL REFERENCE TO DIAGNOSIS AND DESENSITIZATION].
    Gruzlica (Warsaw, Poland : 1926), 1964, Volume: 32

    Topics: Adrenal Cortex Hormones; Aminosalicylic Acid; Aminosalicylic Acids; Anti-Bacterial Agents; Arthritis

1964
[EXPERIENCES IN THE TREATMENT OF VIRAL HEPATITIS IN TUBERCULOUS PATIENTS].
    Tuberkulozis es tudobetegsegek, 1963, Volume: 16

    Topics: Adrenal Cortex Hormones; Communicable Diseases; Cycloserine; Drug Therapy; Hepatitis; Hepatitis A; I

1963
MASSIVE LIVER CELL NECROSIS; A RETROSPECTIVE STUDY.
    Archives of internal medicine, 1964, Volume: 114

    Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Hepatitis A; Isoniazid; M

1964
ETHIONAMIDE-INDUCED HEPATITIS. A REVIEW WITH A REPORT OF AN ADDITIONAL CASE.
    The American review of respiratory disease, 1964, Volume: 90

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Biopsy; Chemical and Drug Induced Liver Injury; Cycloseri

1964
[ON TRANSAMINASES PARTICIPATING IN THE CONVERSION OF TYROSINE TO P-HYDROXYPHENYLPYRUVATE].
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1964, Volume: 337

    Topics: Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Hepatitis; Hydrocortisone; Isoniazid; Liv

1964
BLOOD DYSCRASIAS ASSOCIATED WITH ANTITUBERCULOSIS AND/OR TRANQUILIZING CHEMOTHERAPY. A LONG-TERM CLINICAL OBSERVATION.
    Diseases of the chest, 1965, Volume: 47

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Antitubercular Agents; Chemical and Drug Induced Liver In

1965
[ON THE PROBLEM OF LIVER DAMAGE IN TUBERCULOSIS IN CHILDHOOD].
    Monatsschrift fur Kinderheilkunde, 1965, Volume: 113

    Topics: Adolescent; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Child; Drug Therapy; Hepa

1965
Risk factors for side-effects of isoniazid, rifampin and pyrazinamide in patients hospitalized for pulmonary tuberculosis.
    The European respiratory journal, 1996, Volume: 9, Issue:10

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antitubercular Agents; Arthralgia; Child; C

1996
[Anticonvulsant drugs and liver damage (Author's transl)].
    Journal of neurology, 1975, Volume: 208, Issue:3

    Topics: Adult; Anticonvulsants; Antitubercular Agents; Autopsy; Chemical and Drug Induced Liver Injury; Chol

1975
[Clinical aspects of chronic hepatitis. Diagnosis and differential diagnosis].
    ZFA. Zeitschrift fur Allgemeinmedizin, 1978, Mar-10, Volume: 54, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Chronic Disease; Diagnosis, Differential; Female; Hepatitis;

1978
Granulomatous hepatitis and pleuritis after ileal bypass for obesity.
    The American journal of clinical nutrition, 1978, Volume: 31, Issue:11

    Topics: Ethambutol; Female; Hepatitis; Humans; Ileum; Intestinal Absorption; Isoniazid; Jejunum; Middle Aged

1978
[A case of isoniazid hepatitis in a child].
    Schweizerische medizinische Wochenschrift, 1974, Sep-21, Volume: 104, Issue:38

    Topics: Chemical and Drug Induced Liver Injury; Child, Preschool; Ethambutol; Female; Hepatitis; Humans; Iso

1974
[Immunity and allergy depression during rubella in a child with primary tuberculosis and isoniazid intolerance].
    Annales de medecine interne, 1972, Volume: 123, Issue:11

    Topics: Aminosalicylic Acids; Anaphylaxis; Child, Preschool; Drug Hypersensitivity; Fever; Hepatitis; Hepato

1972
Granulomatous hepatitis and prolonged fever of unknown origin: a study of 13 patients.
    Medicine, 1973, Volume: 52, Issue:1

    Topics: Adult; Ascites; Dexamethasone; Edema; Female; Fever; Fever of Unknown Origin; Granuloma; Hepatitis;

1973
Granulomatous hepatitis and prolonged fever of unknown origin.
    Transactions of the American Clinical and Climatological Association, 1973, Volume: 84

    Topics: Adult; Dexamethasone; Female; Fever; Fever of Unknown Origin; Granuloma; Hepatitis; Hodgkin Disease;

1973
Visceral complications of Gambian trypanosomiasis in a Nigerian.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1972, Volume: 66, Issue:1

    Topics: Adult; Aminosalicylic Acids; Ascites; Blood Protein Electrophoresis; Female; Hepatitis; Humans; Ison

1972
[Study of the treatment of liver damage due to several causes in tuberculosis, using ornithine-aspartate].
    Iryo, 1966, Volume: 20, Issue:4

    Topics: Aspartic Acid; Blood Transfusion; Female; Hepatitis; Hepatitis B; Humans; Isoniazid; Male; Ornithine

1966