isoniazid has been researched along with Hepatic Failure in 15 studies
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two patients with liver failure secondary to isoniazid hepatotoxicity were successfully treated with orthotopic liver transplantation." | 8.79 | Treatment of hepatic failure secondary to isoniazid hepatitis with liver transplantation. ( Esquivel, CO; Farrell, FJ; Imperial, JC; Keeffe, EB; Man, KM, 1994) |
| "Isoniazid (INH)-induced hepatotoxicity remains one of the most common causes of drug-induced idiosyncratic liver injury and liver failure." | 7.80 | Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure. ( Lee, WM; Metushi, IG; Sanders, C; Uetrecht, J, 2014) |
| "Isoniazid (INH) therapy is associated with a significant incidence of idiosyncratic liver failure." | 7.80 | IgG3 is the dominant subtype of anti-isoniazid antibodies in patients with isoniazid-induced liver failure. ( Lee, WM; Metushi, IG; Uetrecht, J, 2014) |
| "Isoniazid (INH) therapy for tuberculosis carries a known risk for hepatoxicity, and leads to hepatic failure in a small subset of patients." | 7.74 | Isoniazid-related hepatic failure in children: a survey of liver transplantation centers. ( Ament, ME; Chao, CS; Martín, MG; McDiarmid, SV; Sharp, HL; Sinatra, FR; Vargas, JH; Wu, SS, 2007) |
| "Two patients with liver failure secondary to isoniazid hepatotoxicity were successfully treated with orthotopic liver transplantation." | 4.79 | Treatment of hepatic failure secondary to isoniazid hepatitis with liver transplantation. ( Esquivel, CO; Farrell, FJ; Imperial, JC; Keeffe, EB; Man, KM, 1994) |
| "Isoniazid preventive therapy (IPT) reduces mortality among people living with HIV (PLHIV) and is recommended for those without active tuberculosis (TB) symptoms." | 3.88 | Isoniazid Preventive Therapy for People With HIV Who Are Heavy Alcohol Drinkers in High TB-/HIV-Burden Countries: A Risk-Benefit Analysis. ( Ellner, JJ; Freiman, JM; Hahn, JA; Horsburgh, CR; Jacobson, KR; Linas, BP; Muyindike, WR, 2018) |
| "Isoniazid (INH)-induced hepatotoxicity remains one of the most common causes of drug-induced idiosyncratic liver injury and liver failure." | 3.80 | Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure. ( Lee, WM; Metushi, IG; Sanders, C; Uetrecht, J, 2014) |
| "Isoniazid (INH) therapy is associated with a significant incidence of idiosyncratic liver failure." | 3.80 | IgG3 is the dominant subtype of anti-isoniazid antibodies in patients with isoniazid-induced liver failure. ( Lee, WM; Metushi, IG; Uetrecht, J, 2014) |
| "Isoniazid (INH) therapy for tuberculosis carries a known risk for hepatoxicity, and leads to hepatic failure in a small subset of patients." | 3.74 | Isoniazid-related hepatic failure in children: a survey of liver transplantation centers. ( Ament, ME; Chao, CS; Martín, MG; McDiarmid, SV; Sharp, HL; Sinatra, FR; Vargas, JH; Wu, SS, 2007) |
| "Four patients presented hepatic encephalopathy." | 1.29 | [Severe hepatotoxicity of tuberculostatic agents. Increase in the incidence]. ( Bruguera, M; Mas, A; Moitinho, E; Rodés, J; Salmerón, JM, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Freiman, JM | 1 |
| Jacobson, KR | 1 |
| Muyindike, WR | 1 |
| Horsburgh, CR | 1 |
| Ellner, JJ | 1 |
| Hahn, JA | 1 |
| Linas, BP | 1 |
| Jung, BH | 1 |
| Park, JI | 1 |
| Lee, SG | 1 |
| Science, M | 1 |
| Ito, S | 1 |
| Kitai, I | 1 |
| Metushi, IG | 2 |
| Sanders, C | 1 |
| Lee, WM | 2 |
| Uetrecht, J | 2 |
| Kumar, N | 1 |
| Kedarisetty, CK | 1 |
| Kumar, S | 1 |
| Khillan, V | 1 |
| Sarin, SK | 1 |
| Gray, D | 1 |
| Nuttall, J | 1 |
| Lombard, C | 1 |
| Davies, MA | 1 |
| Workman, L | 1 |
| Apolles, P | 1 |
| Eley, B | 1 |
| Cotton, M | 1 |
| Zar, HJ | 1 |
| Zar, H | 1 |
| Story, RE | 1 |
| Ditto, AM | 1 |
| Wu, SS | 1 |
| Chao, CS | 1 |
| Vargas, JH | 1 |
| Sharp, HL | 1 |
| Martín, MG | 1 |
| McDiarmid, SV | 1 |
| Sinatra, FR | 1 |
| Ament, ME | 1 |
| Harada, Y | 1 |
| Kawakami, K | 1 |
| Koyama, K | 1 |
| Yamaryo, T | 1 |
| Kimura, Y | 1 |
| Farrell, FJ | 1 |
| Keeffe, EB | 1 |
| Man, KM | 1 |
| Imperial, JC | 1 |
| Esquivel, CO | 1 |
| Hasagawa, T | 1 |
| Reyes, J | 1 |
| Nour, B | 1 |
| Tzakis, AG | 1 |
| Green, M | 1 |
| Todo, S | 1 |
| Starzl, TE | 1 |
| Moitinho, E | 1 |
| Salmerón, JM | 1 |
| Mas, A | 1 |
| Bruguera, M | 1 |
| Rodés, J | 1 |
| Spike, J | 1 |
| Black, M | 1 |
| Hussain, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for isoniazid and Hepatic Failure
| Article | Year |
|---|---|
Antitubercular therapy in patients with cirrhosis: challenges and options.
Topics: Antitubercular Agents; Ethambutol; Humans; Immune System Diseases; Isoniazid; Latent Tuberculosis; L | 2014 |
Treatment of hepatic failure secondary to isoniazid hepatitis with liver transplantation.
Topics: Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Hepatic Encephalopathy; H | 1994 |
13 other studies available for isoniazid and Hepatic Failure
| Article | Year |
|---|---|
Isoniazid Preventive Therapy for People With HIV Who Are Heavy Alcohol Drinkers in High TB-/HIV-Burden Countries: A Risk-Benefit Analysis.
Topics: Adult; Alcoholism; Anti-Retroviral Agents; Antitubercular Agents; Brazil; Chemoprevention; Female; H | 2018 |
Urgent Living-Donor Liver Transplantation in a Patient With Concurrent Active Tuberculosis: A Case Report.
Topics: Antitubercular Agents; Humans; Isoniazid; Levofloxacin; Liver Failure; Liver Transplantation; Living | 2018 |
Isoniazid toxicity in a 5-year-old boy.
Topics: Abdominal Pain; Antitubercular Agents; Child, Preschool; Diagnosis, Differential; Humans; Isoniazid; | 2013 |
Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure.
Topics: Adult; Aged; Antibodies; Antitubercular Agents; Aryl Hydrocarbon Hydroxylases; Autoantibodies; Chemi | 2014 |
IgG3 is the dominant subtype of anti-isoniazid antibodies in patients with isoniazid-induced liver failure.
Topics: Antitubercular Agents; Chemical and Drug Induced Liver Injury; Humans; Immunoglobulin G; Isoniazid; | 2014 |
Low rates of hepatotoxicity in HIV-infected children on anti-retroviral therapy with and without isoniazid prophylaxis.
Topics: AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antitubercular Agents; Child, Preschool; Fem | 2010 |
A 32-year-old man with tuberculosis, fever, and rash.
Topics: Adult; Antitubercular Agents; Diagnosis, Differential; Drug Hypersensitivity; Ethambutol; Exanthema; | 2004 |
Isoniazid-related hepatic failure in children: a survey of liver transplantation centers.
Topics: Adolescent; Antitubercular Agents; Child; Child, Preschool; Female; Follow-Up Studies; Hospitals, Pe | 2007 |
[Case of fatal liver failure due to anti-tuberculous therapy].
Topics: Aged; Antitubercular Agents; Drug Therapy, Combination; Ethambutol; Fatal Outcome; Female; Humans; I | 2007 |
Successful liver transplantation for isoniazid-induced hepatic failure--a case report.
Topics: Adolescent; Female; Humans; Isoniazid; Liver Failure; Liver Transplantation | 1994 |
[Severe hepatotoxicity of tuberculostatic agents. Increase in the incidence].
Topics: Acute Disease; Adult; Antibiotics, Antitubercular; Antitubercular Agents; Chemical and Drug Induced | 1996 |
Iatrogenic liver failure, transplantation, and prisoners.
Topics: Adult; Antitubercular Agents; Ethics Consultation; Ethics, Medical; Humans; Iatrogenic Disease; Ison | 1997 |
Hydrazine, cancer, the Internet, isoniazid, and the liver.
Topics: Antineoplastic Agents; Complementary Therapies; Humans; Hydrazines; Internet; Isoniazid; Liver Failu | 2000 |