isoniazid has been researched along with Friedreich Ataxia in 2 studies
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).
Friedreich Ataxia: An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with peripheral neuropathies it was often possible to obtain nerve velocities with signal amplitudes as low as 0·1 μV and these were often slower than those obtained from the normal subjects." | 1.25 | Sensory conduction in peroneal and posterior tibial nerves using averaging techniques. ( Lovelace, RE; Myers, SJ; Zablow, L, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Richardson, DR | 1 |
| Mouralian, C | 1 |
| Ponka, P | 1 |
| Becker, E | 1 |
| Lovelace, RE | 1 |
| Myers, SJ | 1 |
| Zablow, L | 1 |
2 other studies available for isoniazid and Friedreich Ataxia
| Article | Year |
|---|---|
Development of potential iron chelators for the treatment of Friedreich's ataxia: ligands that mobilize mitochondrial iron.
Topics: Animals; Drug Design; Friedreich Ataxia; Iron; Iron Chelating Agents; Iron Radioisotopes; Isoniazid; | 2001 |
Sensory conduction in peroneal and posterior tibial nerves using averaging techniques.
Topics: Action Potentials; Adolescent; Adult; Aged; Computers, Analog; Diabetic Neuropathies; Electric Stimu | 1973 |