isoniazid has been researched along with Drug Overdose in 49 studies
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report three patients who experienced hepatotoxic reactions in association with acetaminophen ingestion while undergoing treatment for active tuberculosis with isoniazid, rifampin, and other agents." | 7.69 | Hepatotoxicity associated with acetaminophen usage in patients receiving multiple drug therapy for tuberculosis. ( Nelson, SD; Nolan, CM; Sandblom, RE; Slattery, JT; Thummel, KE, 1994) |
| "Overingestion of isoniazid can cause confusion, slurred speech, seizures, coma, and death." | 7.69 | Coma from long-term overingestion of isoniazid. ( Hewitt, CC; Salkind, AR, 1997) |
| "Isoniazid (INH) is an effective treatment for tuberculosis and among the most common causes of drug-induced seizures in the United States." | 5.36 | Isoniazid-induced status epilepticus in a pediatric patient after inadequate pyridoxine therapy. ( Clark, RF; Ghafouri, N; Minns, AB, 2010) |
| "She was in respiratory failure, with seizures that could not be stopped with diazepam." | 5.29 | [Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose]. ( Adler, M; Girsh-Solomonovich, Z; Raikhlin-Eisenkraft, B, 1993) |
| "Pyridoxine has been reported to be effective in treating isoniazid-induced seizures." | 5.28 | Reversal of prolonged isoniazid-induced coma by pyridoxine. ( Brent, J; Kulig, K; Rumack, BH; Vo, N, 1990) |
| "A 25-year-old, 54-kg Hispanic man who had recently started multidrug therapy for pulmonary tuberculosis presented in status epilepticus after ingesting 9 g of isoniazid in a suicide attempt." | 3.73 | Acute isoniazid toxicity and the need for adequate pyridoxine supplies. ( Malesker, M; Morrow, LE; Schuller, D; Wear, RE, 2006) |
| "We report three patients who experienced hepatotoxic reactions in association with acetaminophen ingestion while undergoing treatment for active tuberculosis with isoniazid, rifampin, and other agents." | 3.69 | Hepatotoxicity associated with acetaminophen usage in patients receiving multiple drug therapy for tuberculosis. ( Nelson, SD; Nolan, CM; Sandblom, RE; Slattery, JT; Thummel, KE, 1994) |
| "Overingestion of isoniazid can cause confusion, slurred speech, seizures, coma, and death." | 3.69 | Coma from long-term overingestion of isoniazid. ( Hewitt, CC; Salkind, AR, 1997) |
| " Inter-individual pharmacokinetic variability and the effect of age, nutritional status, Human immunodeficiency virus (HIV) infection, acetylator genotype may need to be accounted for in striving for the dosages best suited for an individual." | 2.61 | Pharmacokinetics of First-Line Anti-Tubercular Drugs. ( Kabra, SK; Lodha, R; Mukherjee, A, 2019) |
| "Isoniazid overdose is a potentially fatal intoxication." | 2.39 | Isoniazid overdose: four case reports and review of the literature. ( Alvarez, FG; Guntupalli, KK, 1995) |
| "Isoniazid has a low therapeutic margin and produces life threatening signs in dogs ingesting single 300 mg human tablets." | 2.39 | Treatment of acute isoniazid overdose in dogs. ( Barret, GH; Buck, WB; Holding, J; Knight, MK; Villar, D, 1995) |
| "Isoniazid is a rare overdose that causes seizures and there is limited evidence to guide treatment." | 1.42 | Isoniazid poisoning: Pharmacokinetics and effect of hemodialysis in a massive ingestion. ( Isbister, GK; Medley, G; Mostafa, A; Roberts, MS; Saiao, A; Skinner, K; Soderstrom, J, 2015) |
| "Isoniazid (INH) is an effective treatment for tuberculosis and among the most common causes of drug-induced seizures in the United States." | 1.36 | Isoniazid-induced status epilepticus in a pediatric patient after inadequate pyridoxine therapy. ( Clark, RF; Ghafouri, N; Minns, AB, 2010) |
| " This case highlights the importance of the correct administration and dosing of BCG vaccine and suggests a management option that may prevent the severe local and systemic complications that are frequently associated with BCG overdose." | 1.35 | Too much of a good thing: management of BCG vaccine overdose. ( Curtis, N; Ritz, N; Streeton, J; Tebruegge, M, 2009) |
| " Thereafter, two groups of 15 male Sprague-Dawley rats each were treated with the toxic dose of paracetamol intraperitoneally to induce severe hepatotoxicity." | 1.32 | The role of cytochrome-P450 inhibitors in the prevention of hepatotoxicity after paracetamol overdose in rats. ( Abraham, AM; Barr, S; Coetsee, C; Walubo, A, 2004) |
| "Of 233 charts coded as involving seizures, 191 occurred in humans and were available for analysis." | 1.29 | Seizures associated with poisoning and drug overdose. ( Benowitz, NL; Blanc, PD; Dyer, JE; Kearney, TE; Olson, KR, 1993) |
| "She was in respiratory failure, with seizures that could not be stopped with diazepam." | 1.29 | [Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose]. ( Adler, M; Girsh-Solomonovich, Z; Raikhlin-Eisenkraft, B, 1993) |
| "Pyridoxine has been reported to be effective in treating isoniazid-induced seizures." | 1.28 | Reversal of prolonged isoniazid-induced coma by pyridoxine. ( Brent, J; Kulig, K; Rumack, BH; Vo, N, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (12.24) | 18.7374 |
| 1990's | 23 (46.94) | 18.2507 |
| 2000's | 12 (24.49) | 29.6817 |
| 2010's | 7 (14.29) | 24.3611 |
| 2020's | 1 (2.04) | 2.80 |
| Authors | Studies |
|---|---|
| Marano, M | 3 |
| Lonati, D | 3 |
| Torroni, F | 3 |
| Agarwal, A | 1 |
| Sharma, S | 1 |
| Bansal, R | 1 |
| Meena, M | 1 |
| Airun, M | 1 |
| Mukherjee, A | 1 |
| Lodha, R | 1 |
| Kabra, SK | 1 |
| Pawlas, N | 1 |
| Miskiewicz, Ł | 1 |
| Motyka, S | 1 |
| Nowakowski, R | 1 |
| Pajak, J | 1 |
| Celiński, R | 1 |
| Kłopotowski, T | 1 |
| Skinner, K | 1 |
| Saiao, A | 1 |
| Mostafa, A | 1 |
| Soderstrom, J | 1 |
| Medley, G | 1 |
| Roberts, MS | 1 |
| Isbister, GK | 1 |
| Bateman, DN | 1 |
| Page, CB | 1 |
| Wretman, M | 1 |
| Agrawal, RL | 1 |
| Dwivedi, NC | 1 |
| Agrawal, M | 1 |
| Jain, S | 1 |
| Agrawal, A | 1 |
| Kalaci, A | 1 |
| Duru, M | 1 |
| Karazincir, S | 1 |
| Sevinç, TT | 1 |
| Kuvandik, G | 1 |
| Balci, A | 1 |
| Ritz, N | 1 |
| Tebruegge, M | 1 |
| Streeton, J | 1 |
| Curtis, N | 1 |
| Minns, AB | 1 |
| Ghafouri, N | 1 |
| Clark, RF | 1 |
| Knapp, JF | 1 |
| Johnson, T | 1 |
| Alander, S | 1 |
| Kürşad, H | 1 |
| Kizilkaya, M | 1 |
| Sahin, M | 1 |
| Dogan, N | 1 |
| Ilgaz, A | 1 |
| Caksen, H | 1 |
| Odabas, D | 1 |
| Erol, M | 1 |
| Anlar, O | 1 |
| Tuncer, O | 1 |
| Atas, B | 1 |
| GLAUBITZ, E | 1 |
| LIVINGSTON, S | 1 |
| PETERSEN, D | 1 |
| PECK, JL | 1 |
| HYATT, HW | 1 |
| GRIFFITH, AH | 1 |
| STARKE, H | 1 |
| WILLIAMS, S | 1 |
| MARTIN, U | 1 |
| Walubo, A | 1 |
| Barr, S | 1 |
| Abraham, AM | 1 |
| Coetsee, C | 1 |
| McLay, RN | 1 |
| Drake, A | 1 |
| Rayner, T | 1 |
| Tibussek, D | 1 |
| Mayatepek, E | 1 |
| Distelmaier, F | 1 |
| Rosenbaum, T | 1 |
| Morrow, LE | 1 |
| Wear, RE | 1 |
| Schuller, D | 1 |
| Malesker, M | 1 |
| Nolan, CM | 1 |
| Sandblom, RE | 1 |
| Thummel, KE | 1 |
| Slattery, JT | 1 |
| Nelson, SD | 1 |
| Aggarwal, P | 1 |
| Kumar, S | 1 |
| Rao, S | 1 |
| Ramiah, I | 1 |
| Jayaram, A | 1 |
| Scharman, EJ | 1 |
| Rosencrane, JG | 1 |
| Olson, KR | 1 |
| Kearney, TE | 1 |
| Dyer, JE | 1 |
| Benowitz, NL | 1 |
| Blanc, PD | 1 |
| Adler, M | 1 |
| Girsh-Solomonovich, Z | 1 |
| Raikhlin-Eisenkraft, B | 1 |
| Alvarez, FG | 1 |
| Guntupalli, KK | 1 |
| Villar, D | 1 |
| Knight, MK | 1 |
| Holding, J | 1 |
| Barret, GH | 1 |
| Buck, WB | 1 |
| Wilcox, WD | 1 |
| Hacker, YE | 1 |
| Geller, RJ | 1 |
| Langdana, A | 1 |
| Agarwal, M | 1 |
| Kelgeri, C | 1 |
| Kamat, P | 1 |
| Nixon, GM | 1 |
| Stanley, TV | 1 |
| Tai, DY | 1 |
| Yeo, JK | 1 |
| Eng, PC | 1 |
| Wang, YT | 1 |
| Salkind, AR | 1 |
| Hewitt, CC | 1 |
| Romero, JA | 1 |
| Kuczler, FJ | 1 |
| de Silva, AP | 1 |
| Premaratne, R | 1 |
| Gunatilake, SB | 1 |
| Fonseka, MM | 1 |
| de Silva, HJ | 1 |
| Nelson, LS | 1 |
| Rella, J | 1 |
| Hoffman, RS | 1 |
| McGuigan, MA | 1 |
| Yamada, J | 1 |
| Temmerman, W | 1 |
| Dhondt, A | 1 |
| Vandewoude, K | 1 |
| Steinmann, RA | 1 |
| Rickel, MK | 1 |
| Ireland, JW | 1 |
| Aoki, B | 1 |
| Cash, JM | 1 |
| Zawada, ET | 1 |
| Jonville, AP | 1 |
| Gauchez, AS | 1 |
| Autret, E | 1 |
| Billard, C | 1 |
| Barbier, P | 1 |
| Nsabiyumva, F | 1 |
| Breteau, M | 1 |
| Brent, J | 1 |
| Vo, N | 1 |
| Kulig, K | 1 |
| Rumack, BH | 1 |
| Bredemann, JA | 1 |
| Krechel, SW | 1 |
| Eggers, GW | 1 |
| Murphy, R | 1 |
| Swartz, R | 1 |
| Watkins, PB | 1 |
7 reviews available for isoniazid and Drug Overdose
| Article | Year |
|---|---|
Pharmacokinetics of First-Line Anti-Tubercular Drugs.
Topics: Age Factors; Antitubercular Agents; Child; Drug Overdose; Ethambutol; Food; Genotype; HIV Infections | 2019 |
Antidotes to coumarins, isoniazid, methotrexate and thyroxine, toxins that work via metabolic processes.
Topics: Antidotes; Coumarins; Disease Management; Drug Overdose; Humans; Isoniazid; Methotrexate; Thyroxine | 2016 |
Isoniazid overdose: four case reports and review of the literature.
Topics: Acidosis; Adolescent; Adult; Antitubercular Agents; Drug Overdose; Female; Humans; Isoniazid; Male; | 1995 |
Treatment of acute isoniazid overdose in dogs.
Topics: Administration, Oral; Animals; Anticonvulsants; Antitubercular Agents; Cats; Diazepam; Dog Diseases; | 1995 |
Intentional overdosage with isoniazid: case report and review of literature.
Topics: Adult; Antitubercular Agents; Drug Overdose; Humans; Isoniazid; Male; Suicide, Attempted; Tuberculos | 1996 |
Isoniazid overdose: recognition and management.
Topics: Adolescent; Drug Overdose; Humans; Isoniazid; Male | 1998 |
Acute isoniazid intoxication: seizures, acidosis and coma.
Topics: Acidosis; Acute Disease; Adolescent; Antitubercular Agents; Coma; Diagnosis, Differential; Drug Over | 1999 |
42 other studies available for isoniazid and Drug Overdose
| Article | Year |
|---|---|
Pharmacobezoar after overdose of isoniazid and rifampin.
Topics: Adolescent; Drug Overdose; Gastric Lavage; Humans; Isoniazid; Rifampin; Stomach | 2023 |
Pharmacobezoar after overdose of isoniazid and rifampin.
Topics: Adolescent; Drug Overdose; Gastric Lavage; Humans; Isoniazid; Rifampin; Stomach | 2023 |
Pharmacobezoar after overdose of isoniazid and rifampin.
Topics: Adolescent; Drug Overdose; Gastric Lavage; Humans; Isoniazid; Rifampin; Stomach | 2023 |
Pharmacobezoar after overdose of isoniazid and rifampin.
Topics: Adolescent; Drug Overdose; Gastric Lavage; Humans; Isoniazid; Rifampin; Stomach | 2023 |
Pharmacobezoar after overdose of isoniazid and rifampin.
Topics: Adolescent; Drug Overdose; Gastric Lavage; Humans; Isoniazid; Rifampin; Stomach | 2023 |
Pharmacobezoar after overdose of isoniazid and rifampin.
Topics: Adolescent; Drug Overdose; Gastric Lavage; Humans; Isoniazid; Rifampin; Stomach | 2023 |
Pharmacobezoar after overdose of isoniazid and rifampin.
Topics: Adolescent; Drug Overdose; Gastric Lavage; Humans; Isoniazid; Rifampin; Stomach | 2023 |
Pharmacobezoar after overdose of isoniazid and rifampin.
Topics: Adolescent; Drug Overdose; Gastric Lavage; Humans; Isoniazid; Rifampin; Stomach | 2023 |
Pharmacobezoar after overdose of isoniazid and rifampin.
Topics: Adolescent; Drug Overdose; Gastric Lavage; Humans; Isoniazid; Rifampin; Stomach | 2023 |
Near Fatal Poisoning by Isoniazid and Rifampicin.
Topics: Adult; Antitubercular Agents; Drug Overdose; Humans; Isoniazid; Male; Rifampin; Severity of Illness | 2016 |
Fatal suicidal poisoning with antituberculosis agents with ST elevation and acute coronary syndrome symptoms--a case report.
Topics: Acute Coronary Syndrome; Antitubercular Agents; Drug Overdose; Echocardiography; Ethanol; Fatal Outc | 2013 |
Isoniazid poisoning: Pharmacokinetics and effect of hemodialysis in a massive ingestion.
Topics: Adult; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Isoniazid; Re | 2015 |
[Overdose of tuberculosis drugs common among young asylum seekers].
Topics: Adolescent; Antitubercular Agents; Child; Drug Overdose; Humans; Isoniazid; Refugees; Seizures | 2016 |
Accidental isoniazid poisoning--a report.
Topics: Acidosis; Adolescent; Adult; Antitubercular Agents; Drug Overdose; Electroencephalography; Gastric L | 2008 |
Thoracic spine compression fracture during isoniazid-induced seizures: case report.
Topics: Antidotes; Back Pain; Charcoal; Child; Drug Overdose; Epilepsy, Tonic-Clonic; Female; Fractures, Com | 2008 |
Too much of a good thing: management of BCG vaccine overdose.
Topics: Adolescent; Antitubercular Agents; BCG Vaccine; Dermatologic Surgical Procedures; Drug Overdose; Fem | 2009 |
Isoniazid-induced status epilepticus in a pediatric patient after inadequate pyridoxine therapy.
Topics: Antitubercular Agents; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Overdose; Hum | 2010 |
Seizures in a 13-year-old girl.
Topics: Acidosis; Adolescent; Antitubercular Agents; Asia, Southeastern; Communication Barriers; Diagnosis, | 2003 |
Treatment of acute isoniazid toxicity of unknown dose.
Topics: Adult; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; | 2003 |
Do not overlook acute isoniazid poisoning in children with status epilepticus.
Topics: Acidosis; Antitubercular Agents; Child, Preschool; Diagnosis, Differential; Diazepam; Drug Overdose; | 2003 |
[Side-effects in overdosage of isonicotinic acid hydrazide].
Topics: Central Nervous System; Drug Overdose; Isoniazid; Nervous System; Niacin; Nicotinic Acids; Tuberculo | 1953 |
Convulsive reaction in a two-year-old child following the accidental ingestion of an overdosage of isoniazid.
Topics: Barbiturates; Child; Drug Overdose; Humans; Infant; Isoniazid; Niacin; Nicotinic Acids; Poisoning; S | 1956 |
Acute poisoning from overdose of isoniazid. Two accidental cases in children admitted to the same hospital on successive davs.
Topics: Child; Drug Overdose; Hospitalization; Hospitals; Humans; Infant; Isoniazid; Poisoning | 1961 |
Ten cases of BCG overdosage treated with isoniazid.
Topics: BCG Vaccine; Drug Overdose; Humans; Isoniazid; Mycobacterium bovis; Vaccination | 1963 |
ACUTE POISONING FROM OVERDOSE OF ISONIAZID; A CASE REPORT.
Topics: Black People; Drug Overdose; Humans; Infant; Isoniazid; Pyridoxine; Seizures; Toxicology | 1963 |
[Burning-feet-syndrome caused by overdose of isoniazid].
Topics: Drug Overdose; Foot Diseases; Isoniazid; Niacin; Nicotinic Acids; Peripheral Nervous System Diseases | 1955 |
The role of cytochrome-P450 inhibitors in the prevention of hepatotoxicity after paracetamol overdose in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome | 2004 |
Persisting dementia after isoniazid overdose.
Topics: Adult; Antitubercular Agents; Dementia; Drug Overdose; Humans; Isoniazid; Male; Neurologic Examinati | 2005 |
Status epilepticus due to attempted suicide with isoniazid.
Topics: Antitubercular Agents; Child; Drug Overdose; Female; Humans; Isoniazid; Status Epilepticus; Suicide, | 2006 |
Acute isoniazid toxicity and the need for adequate pyridoxine supplies.
Topics: Acute Disease; Adult; Antidotes; Antitubercular Agents; Drug Overdose; Drugs, Essential; Humans; Inf | 2006 |
Hepatotoxicity associated with acetaminophen usage in patients receiving multiple drug therapy for tuberculosis.
Topics: Acetaminophen; Adult; Capreomycin; Ciprofloxacin; Drug Combinations; Drug Overdose; Ethambutol; Fema | 1994 |
INH-induced neurotoxicity.
Topics: Acidosis; Adult; Brain; Drug Overdose; Humans; Isoniazid; Pyridoxine; Seizures | 1994 |
A case of neurotoxicity due to INH.
Topics: Adult; Critical Care; Dose-Response Relationship, Drug; Drug Overdose; Epilepsy, Tonic-Clonic; Human | 1993 |
Isoniazid toxicity: a survey of pyridoxine availability.
Topics: Data Collection; Drug Overdose; Humans; Isoniazid; Pharmacy Service, Hospital; Pyridoxine; Tuberculo | 1994 |
Seizures associated with poisoning and drug overdose.
Topics: Adolescent; Adult; Age Factors; Aged; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Caus | 1993 |
[Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose].
Topics: Acidosis; Adolescent; Drug Overdose; Female; Humans; Infusions, Intravenous; Isoniazid; Pyridoxine; | 1993 |
Acute isoniazid overdose in a compliant adolescent patient.
Topics: Child; Drug Overdose; Female; Humans; Isoniazid; Patient Compliance; Patient Education as Topic; Sel | 1996 |
Pyridoxine in acute isoniazid overdose.
Topics: Antitubercular Agents; Child; Child, Preschool; Drug Overdose; Female; Humans; Isoniazid; Pyridoxine | 1996 |
Status epilepticus due to accidental overdose of isoniazid in an infant.
Topics: Drug Overdose; Female; Humans; Infant; Isoniazid; Status Epilepticus; Tuberculosis | 1996 |
Coma from long-term overingestion of isoniazid.
Topics: Antitubercular Agents; Coma; Drug Overdose; Humans; Isoniazid; Male; Middle Aged | 1997 |
Red (wo)man syndrome.
Topics: Adolescent; Antibiotics, Antitubercular; Antitubercular Agents; Disease-Free Survival; Drug Overdose | 1998 |
Status epilepticus.
Topics: Drug Overdose; Humans; Isoniazid; Pyridoxine; Status Epilepticus | 1998 |
The geographic distribution of tuberculosis and pyridoxine supply in Ontario.
Topics: Antitubercular Agents; Drug Overdose; Health Services Needs and Demand; Humans; Injections, Intraven | 1995 |
A 23-year-old with refractory seizures following an isoniazid overdose.
Topics: Adult; Anticonvulsants; Drug Overdose; Follow-Up Studies; Humans; Isoniazid; Male; Recurrence; Risk | 2002 |
A 14-year-old girl with refractory seizures.
Topics: Adolescent; Antitubercular Agents; Drug Overdose; Female; Humans; Isoniazid; Seizures; Self Medicati | 2001 |
Isoniazid overdose. Successful treatment with pyridoxine and hemodialysis.
Topics: Adolescent; Drug Overdose; Humans; Isoniazid; Male; Poisoning; Pyridoxine; Renal Dialysis | 1991 |
Interaction between isoniazid and valproate: a case of valproate overdosage.
Topics: Child, Preschool; Drug Interactions; Drug Overdose; Female; Humans; Isoniazid; Valproic Acid | 1991 |
Reversal of prolonged isoniazid-induced coma by pyridoxine.
Topics: Adolescent; Adult; Coma; Drug Overdose; Female; Humans; Isoniazid; Male; Pyridoxine | 1990 |
Treatment of refractory seizures in massive isoniazid overdose.
Topics: Adult; Drug Overdose; Humans; Isoniazid; Male; Seizures; Suicide, Attempted | 1990 |
Severe acetaminophen toxicity in a patient receiving isoniazid.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Interact | 1990 |