isoniazid has been researched along with Carcinoma, Hepatocellular in 14 studies
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this study was to evaluate the association between the use of anti-tuberculosis (anti-TB) agents, isoniazid (INH), rifampicin (RIF), and their combination (INH + RIF), and the risk of hepatocellular carcinoma (HCC) in cirrhotic patients." | 3.81 | Anti-tuberculosis treatments and risk of hepatocellular carcinoma in tuberculosis patients with liver cirrhosis: a population-based case-control study. ( Hung, DZ; Kao, CH; Lim, YP; Lin, CL; Lin, YN, 2015) |
| "Isoniazid has recently been reported to upregulate Alas1 but downregulate Fech protein levels in mice; however, the mechanism by which isoniazid mediates disruption of heme synthesis has been unclear." | 1.51 | The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis. ( Brewer, CT; Chen, T; Edwards, A; Lee, RE; Low, J; Lu, Y; Wu, J; Yang, L, 2019) |
| "Using the on-chip activity assay, hepatocellular carcinoma patients (n = 24), but not hepatitis (n = 24) or liver cirrhosis patients (n = 41), had significantly lower FXIII activities (p < 0." | 1.37 | Rapid determination of blood coagulation factor XIII activity using protein arrays for serodiagnosis of human plasma. ( Ha, KS; Jung, SH; Kim, YM; Kong, DH; Kwon, MH; Suh, IB, 2011) |
| "Isoniazid (INH) continues to be a sheet anchor in treatment of tuberculosis, however its chronic administration is known to cause hepatotoxicity through a poorly defined mechanism." | 1.34 | Isoniazid induces oxidative stress, mitochondrial dysfunction and apoptosis in Hep G2 cells. ( Bhadauria, S; Singh, G; Sinha, N; Srivastava, S, 2007) |
| "The human hepatoma line HepG2, the human lymphoblastoid line AHH-1 and the murine lymphoma cells YAC-1 were used as test systems." | 1.32 | In vitro studies on the toxicity of isoniazid in different cell lines. ( Schwab, CE; Tuschl, H, 2003) |
| " Transfected cells were dosed with several known inducers of CYP3A4 and the levels of SPAP were measured." | 1.30 | A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro. ( Gibson, GG; Goldfarb, PS; Gray, TJ; Ogg, MS; Tarbit, M; Williams, JM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (28.57) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boechat, N | 2 |
| Ferreira, VF | 1 |
| Ferreira, SB | 1 |
| de Lourdes G Ferreira, M | 1 |
| de C da Silva, F | 1 |
| Bastos, MM | 1 |
| Dos S Costa, M | 1 |
| Lourenço, MC | 1 |
| Pinto, AC | 1 |
| Krettli, AU | 1 |
| Aguiar, AC | 1 |
| Teixeira, BM | 1 |
| da Silva, NV | 1 |
| Martins, PR | 1 |
| Bezerra, FA | 1 |
| Camilo, AL | 1 |
| da Silva, GP | 1 |
| Costa, CC | 1 |
| Brewer, CT | 1 |
| Yang, L | 1 |
| Edwards, A | 1 |
| Lu, Y | 1 |
| Low, J | 1 |
| Wu, J | 1 |
| Lee, RE | 1 |
| Chen, T | 1 |
| Lim, YP | 1 |
| Lin, CL | 1 |
| Hung, DZ | 1 |
| Lin, YN | 1 |
| Kao, CH | 1 |
| Kwon, MH | 1 |
| Kong, DH | 1 |
| Jung, SH | 1 |
| Suh, IB | 1 |
| Kim, YM | 1 |
| Ha, KS | 1 |
| BIANCIFIORI, C | 1 |
| BUCCIARELLI, E | 1 |
| CLAYSON, DB | 1 |
| SANTILLI, FE | 1 |
| Schwab, CE | 1 |
| Tuschl, H | 1 |
| Bhadauria, S | 1 |
| Singh, G | 1 |
| Sinha, N | 1 |
| Srivastava, S | 1 |
| Fujii, K | 1 |
| Watanabe, M | 1 |
| Carroccio, A | 1 |
| Wu, D | 1 |
| Cederbaum, AI | 1 |
| Nicod, L | 1 |
| Viollon, C | 1 |
| Regnier, A | 1 |
| Jacqueson, A | 1 |
| Richert, L | 1 |
| Ogg, MS | 1 |
| Williams, JM | 1 |
| Tarbit, M | 1 |
| Goldfarb, PS | 1 |
| Gray, TJ | 1 |
| Gibson, GG | 1 |
| Linnik, AB | 1 |
| Grasso, P | 1 |
| Crampton, RF | 1 |
1 review available for isoniazid and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
The value of the mouse in carcinogenicity testing.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Epithelium; Ethers, Cycli | 1972 |
13 other studies available for isoniazid and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Novel 1,2,3-triazole derivatives for use against Mycobacterium tuberculosis H37Rv (ATCC 27294) strain.
Topics: Antitubercular Agents; Carcinoma, Hepatocellular; Cell Proliferation; Click Chemistry; Humans; Isoni | 2011 |
The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis.
Topics: 5-Aminolevulinate Synthetase; Animals; Carcinoma, Hepatocellular; Ferrochelatase; Heme; Hep G2 Cells | 2019 |
Editorial: new developments in the search for agents to treat tuberculosis.
Topics: Antitubercular Agents; Carcinoma, Hepatocellular; Cell Proliferation; Humans; Isoniazid; Liver Neopl | 2013 |
Anti-tuberculosis treatments and risk of hepatocellular carcinoma in tuberculosis patients with liver cirrhosis: a population-based case-control study.
Topics: Adult; Aged; Aged, 80 and over; Antitubercular Agents; Carcinoma, Hepatocellular; Case-Control Studi | 2015 |
Rapid determination of blood coagulation factor XIII activity using protein arrays for serodiagnosis of human plasma.
Topics: Amines; Biomarkers, Tumor; Biotin; Blood Specimen Collection; Carcinoma, Hepatocellular; Factor XIII | 2011 |
INDUCTION OF HEPATOMAS IN CBA-CB-SE MICE BY HYDRAZINE SULPHATE AND THE LACK OF EFFECT OF CROTON OIL ON TUMOUR INDUCTION IN BALB-C-CB-SE MICE.
Topics: Animals; Carcinoma, Hepatocellular; Croton Oil; Hydrazines; Isoniazid; Isonicotinic Acids; Liver; Li | 1964 |
In vitro studies on the toxicity of isoniazid in different cell lines.
Topics: Animals; Antitubercular Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; DNA Damage; Humans | 2003 |
Isoniazid induces oxidative stress, mitochondrial dysfunction and apoptosis in Hep G2 cells.
Topics: Animals; Antitubercular Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Shape; | 2007 |
Comparative study of tumorigenicity in mice administered transplacentally or neonatally with metabolites of tryptophan and its related compounds.
Topics: 3-Hydroxyanthranilic Acid; Adenoma; Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellula | 1980 |
Ethanol increases content and activity of human cytochrome P4502E1 in a transduced HepG2 cell line.
Topics: Blotting, Western; Carcinoma, Hepatocellular; Cell Line; Cytochrome P-450 CYP2E1; Cytochrome P-450 E | 1994 |
Rifampicin and isoniazid increase acetaminophen and isoniazid cytotoxicity in human HepG2 hepatoma cells.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antitubercular Agents; Carcinoma, Hepatocellular; Cell Surv | 1997 |
A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.
Topics: Alkaline Phosphatase; beta-Naphthoflavone; Caffeine; Carbamazepine; Carcinoma, Hepatocellular; Clofi | 1999 |
[The possible blastomogenic effect of tubazid and phthivazid in experiments on animals].
Topics: Adenoma; Animals; Carcinogens; Carcinoma, Hepatocellular; Female; Isoniazid; Leukemia, Experimental; | 1972 |