isoniazid and Brain Disorders studies

Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).

Research Excerpts

Excerpt	Relevance	Reference
"35 children with suspected tuberculomas of the brain were given a therapeutic 4-drug trial of isoniazid, rifampicin, pyrazinamide and ethambutol."	5.06	Intracranial tuberculomas. An assessment of a therapeutic 4-drug trial in 35 children. ( Domingo, Z; Peter, JC, 1989)
"Intracranial tuberculomas are rare yet lethal forms of tuberculosis."	2.66	Multiple tuberculomas in an immunocompetent patient and their diagnostic challenge in a high prevalence country: Case report and literature review. ( Alva-Diaz, C; Esteban-Arias, D; López-Saavedra, A; Metcalf, T; Orellana-Tovar, I; Pacheco-Barrios, K; Rodriguez-López, E; Velásquez-Rimachi, V, 2020)
"We present a case of isoniazid-induced encephalopathy in a haemodialysis patient."	2.61	Isoniazid-induced encephalopathy in an end-stage renal disease patient - A case report and literature review. ( Low, JM; Wong, KW, 2019)
"Seizures are commonly encountered in patients who do not have epilepsy."	2.40	Medical causes of seizures. ( Delanty, N; French, JA; Vaughan, CJ, 1998)
" EFV is well known to cause neuropsychiatric side-effects on initiation, and a recent adult case series described late-onset neurotoxicity in the form of subacute ataxia and encephalopathy in patients treated with EFV for a median of 2 years, in association with toxic plasma levels of the drug."	1.48	A proposed management algorithm for late-onset efavirenz neurotoxicity. ( Asukile, MT; Chetty, S; Cross, HM; Hussey, HS; Lee Pan, EB; Tucker, LM, 2018)
"Hydrocephalus was demonstrated by cranial computerized tomography in all 30 patients (100%)."	1.28	Central nervous system tuberculosis in children: a review of 30 cases. ( Connor, JD; Waecker, NJ, 1990)
"One patient presented with attacks of hydrocephalus initially diagnosed erroneously as migraine, another had multiple tuberculomas and a fourth tuberculoma became apparent during treatment with antituberculous therapy."	1.25	Three patients with intracranial tuberculomas with unusual features. ( Barwick, DD; Thrush, DC, 1974)

Timeframe	Studies, this research(%)	All Research%
pre-1990	37 (74.00)	18.7374
1990's	5 (10.00)	18.2507
2000's	3 (6.00)	29.6817
2010's	4 (8.00)	24.3611
2020's	1 (2.00)	2.80

Authors	Studies
Low, JM	1
Wong, KW	1
Velásquez-Rimachi, V	1
Orellana-Tovar, I	1
Rodriguez-López, E	1
López-Saavedra, A	1
Esteban-Arias, D	1
Pacheco-Barrios, K	1
Metcalf, T	1
Alva-Diaz, C	1
Constantinescu, SM	1
Buysschaert, B	1
Haufroid, V	1
Broly, F	1
Jadoul, M	1
Morelle, J	1
Cross, HM	1
Chetty, S	1
Asukile, MT	1
Hussey, HS	1
Lee Pan, EB	1
Tucker, LM	1
Kargiotis, O	1
Marangos, M	1
Polychronopoulos, P	1
Dubey, S	1
Devi, BI	1
Jawalkar, VK	1
Bhat, DI	1
CHAPTAL, J	1
JEAN, R	1
CRASTES DE PAULET, A	1
BONNET, H	1
PETIT, M	1
GUILLAUMOT, R	1
KAZANEK, I	1
VASSERMAN, ME	1
SPILLANE, JD	1
BECH, AO	1
TAI, AR	1
ROSEN, JA	1
WANG, Y	1
ADAMS, P	1
WHITE, C	1
PALMER, AC	1
NOEL, PR	1
DEVADATTA, S	1
KRAMER, W	1
Wasay, M	1
Moolani, MK	1
Zaheer, J	1
Kheleani, BA	1
Smego, RA	1
Sarwari, RA	1
Smego, AR	1
Kwon, HM	1
Kim, HK	1
Cho, J	1
Hong, YH	1
Nam, H	1
Kreutzberg, GW	1
Carlton, WW	2
Mahanta, A	1
Kalra, L	1
Maheshwari, MC	1
Mishra, NK	1
Yamamoto, M	1
Otsuki, S	1
Miyake, K	1
Namba, R	1
Frappaz, D	1
Biron, P	1
Biron, E	1
Amrane, A	1
Philip, T	1
Brunat-Mentigny, M	1
Bray, PF	1
Casado de Frias, E	1
Balboa de Paz, F	1
Pérez Martínez Martinez, A	1
Palacio Mestres, C	1
López Gastón, JI	1
Carod Artal, FJ	1
Delanty, N	1
Vaughan, CJ	1
French, JA	1
Elmets, CA	1
Hinthorn, DR	1
Liu, C	1
Rose, FC	1
Destee, A	1
Verrier, A	1
Gelez, P	1
Warot, P	1
Peatfield, RC	1
Shawdon, HH	1
Bondarev, IM	1
Chelnokova, NV	1
Somawardhana, CW	1
Sajjad, M	1
Amartey, JK	1
Lambrecht, RM	1
Waecker, NJ	1
Connor, JD	1
Farrell, VJ	1
Domingo, Z	1
Peter, JC	1
Choudhury, AR	1
Ishii, N	1
Nishihara, Y	1
Yamamoto, N	1
Kadoya, S	1
Nakamura, T	1
Emori, T	1
Kwak, R	1
Hirose, G	1
Ule, G	2
Jacques, S	1
Freshwater, DB	1
Randle, RE	1
Shelden, CH	1
Swash, M	1
Roberts, AH	1
Murnaghan, DJ	1
Thrush, DC	1
Barwick, DD	1
Wegener, K	1
Kolkmann, FW	2
Rein, H	2
Bagchi, AK	1
Pain, HP	1
Phatak, AT	1
Shah, SH	1
Monnet, P	1
Kalb, JC	1
Pujol, M	1
Summers, DS	1
Sil, R	1
Spens, N	1
Tattersall, WH	1
Kreutzberg, G	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Study of Neurological Aging Among People Living With HIV (SNAP)[NCT05678660]				300 participants (Anticipated)	Observational	2022-07-06	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Isoniazid-induced encephalopathy in an end-stage renal disease patient - A case report and literature review. The Medical journal of Malaysia, 2019, Volume: 74, Issue:6 Topics: Antitubercular Agents; Brain Diseases; Female; Humans; Isoniazid; Kidney Failure, Chronic; Middle Ag	2019
Multiple tuberculomas in an immunocompetent patient and their diagnostic challenge in a high prevalence country: Case report and literature review. The Indian journal of tuberculosis, 2020, Volume: 67, Issue:3 Topics: Antitubercular Agents; Blindness; Brain; Brain Diseases; Cerebellar Ataxia; Dexamethasone; Drug Ther	2020
Chronic dialysis, NAT2 polymorphisms, and the risk of isoniazid-induced encephalopathy - case report and literature review. BMC nephrology, 2017, Sep-04, Volume: 18, Issue:1 Topics: Aged; Antitubercular Agents; Arylamine N-Acetyltransferase; Brain Diseases; Humans; Isoniazid; Kidne	2017
Tuberculoma en plaque: a case report. Neurology India, 2002, Volume: 50, Issue:4 Topics: Adolescent; Antitubercular Agents; Brain Diseases; Drug Therapy, Combination; Female; Humans; Isonia	2002
Medical causes of seizures. Lancet (London, England), 1998, Aug-01, Volume: 352, Issue:9125 Topics: Acute Kidney Injury; Anticonvulsants; Antitubercular Agents; Blood Pressure; Brain Diseases; Broncho	1998

Article	Year
A proposed management algorithm for late-onset efavirenz neurotoxicity. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2018, Mar-28, Volume: 108, Issue:4 Topics: Adult; Algorithms; Alkynes; Antitubercular Agents; Benzoxazines; Brain Diseases; Cerebellar Ataxia;	2018
An unusual case of isoniazid toxicity. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2015, Volume: 36, Issue:6 Topics: Aged; Antitubercular Agents; Brain Diseases; Humans; Isoniazid; Male; Tuberculosis, Pulmonary	2015
[Accidents induced by isoniazid during prolonged treatments of tuberculosis in children. I. Clinical study. II. Interpretation. III. Biological results]. Pediatrie, 1960, Volume: 15 Topics: Accidents; Brain; Brain Diseases; Child; Humans; Infant; Isoniazid; Tuberculosis; Tuberculosis, Meni	1960
[RELAPSES IN TUBERCULOUS ENCEPHALITIS AND MENINGOENCEPHALITIS]. Gruzlica (Warsaw, Poland : 1926), 1962, Volume: 30 Topics: Aminosalicylic Acid; Aminosalicylic Acids; Brain Diseases; Child; Encephalitis; Humans; Isoniazid; M	1962
[ATYPICAL TUBERCULOUS INFECTION OF THE BRAIN]. Meditsinskii zhurnal Uzbekistana, 1963, Volume: 6 Topics: Brain; Brain Diseases; Isoniazid; Streptomycin; Tuberculosis; Tuberculosis, Meningeal	1963
IATROGENIC NEUROLOGICAL DISEASES. DRUG-INDUCED NEUROLOGICAL DISORDERS. Proceedings of the Royal Society of Medicine, 1964, Volume: 57 Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antihypertensive Agents	1964
UNUSUAL LATE SEQUELAE OF TUBERCULOUS MENINGITIS. Tubercle, 1964, Volume: 45 Topics: Adolescent; Aminosalicylic Acid; Aminosalicylic Acids; Brain Diseases; Calcinosis; Drug Therapy; Epi	1964
CNS SARCOID GRANULOMA MONITORED BY BRAIN SCANNING. Archives of internal medicine, 1965, Volume: 115 Topics: Brain; Brain Diseases; Drug Therapy; Granuloma; Humans; Isoniazid; Lung Diseases; Mercury; Prednison	1965
ISONIAZID-INDUCED ENCEPHALOPATHY. Lancet (London, England), 1965, Mar-27, Volume: 1, Issue:7387 Topics: Aminosalicylic Acid; Aminosalicylic Acids; Brain Diseases; Diagnosis, Differential; Drug Therapy; Is	1965
NEUROPATHOLOGICAL EFFECTS OF DOSING DOGS WITH ISONICOTINIC HYDRAZIDE AND WITH ITS METHANOSULPHONATE DERIVATIVE. Nature, 1965, Jan-30, Volume: 205 Topics: Brain Diseases; Brain Edema; Capillaries; Cerebrovascular Circulation; Dogs; Hyperplasia; Isoniazid;	1965
ISONIAZID-INDUCED ENCEPHALOPATHY. Lancet (London, England), 1965, Aug-28, Volume: 2, Issue:7409 Topics: Brain Diseases; Drug Therapy; Epilepsy; Epilepsy, Tonic-Clonic; Isoniazid; Peripheral Nervous System	1965
Cerebral complication following isoniazid administration. Acta tuberculosea Scandinavica, 1960, Volume: 38 Topics: Brain; Brain Diseases; Isoniazid	1960
Prognostic indicators in patients with intracranial tuberculoma: a review of 102 cases. JPMA. The Journal of the Pakistan Medical Association, 2004, Volume: 54, Issue:2 Topics: Adolescent; Adult; Antibiotics, Antitubercular; Brain Diseases; Child; Child, Preschool; Drug Therap	2004
Cycloserine-induced encephalopathy: evidence on brain MRI. European journal of neurology, 2008, Volume: 15, Issue:7 Topics: Aged; Antibiotics, Antitubercular; Brain Diseases; Cycloserine; Disorders of Excessive Somnolence; D	2008
Pathogenetic mechanism of experimentally-induced spongy degeneration. Acta neuropathologica, 1967, Oct-20, Volume: 9, Issue:2 Topics: Animals; Brain Diseases; Cell Nucleus; Cerebellar Cortex; Cerebellum; Ducks; Isoniazid; Male; Neurog	1967
Brain-stem tuberculoma: an unusual presentation. Journal of neurology, 1982, Volume: 227, Issue:4 Topics: Adult; Brain Diseases; Brain Stem; Drug Therapy, Combination; Ethambutol; Female; Humans; Isoniazid;	1982
[Lumbar cerebrospinal fluid levels of GABA, HVA and 5HIAA in various patients with choreic movement and effects with isoniazid treatment]. No to shinkei = Brain and nerve, 1983, Volume: 35, Issue:5 Topics: Acanthocytes; Adult; Aged; Atrophy; Brain Diseases; Chorea; gamma-Aminobutyric Acid; Homovanillic Ac	1983
[Severe neurological toxicity (coma, convulsions, distal motor neuropathy) secondary to the association of accidental poisoning by isoniazid and a protocol containing high doses of vincristine]. Pediatrie, 1984, Volume: 39, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Hepatic Encephalopathy; Human	1984
Isoniazid-induced acute toxic encephalopathy. Neurology, 1984, Volume: 34, Issue:5 Topics: Adult; Brain Diseases; Female; Humans; Isoniazid	1984
Inappropriate secretion of antidiuretic hormone and the effect of lithium in its treatment. The Journal of pediatrics, 1980, Volume: 96, Issue:1 Topics: Anti-Bacterial Agents; Brain Death; Brain Diseases; Child, Preschool; Female; Humans; Inappropriate	1980
[Acute recurrent toxic encephalopathy++ induced by isoniazide]. Medicina clinica, 1994, May-21, Volume: 102, Issue:19 Topics: Acute Disease; Adolescent; Brain Diseases; Female; Humans; Isoniazid; Recurrence	1994
Brain tuberculoma. Diagnosis and treatment. The Journal of the Kansas Medical Society, 1979, Volume: 80, Issue:6 Topics: Adult; Aged; Brain Diseases; Female; Humans; Isoniazid; Male; Mycobacterium tuberculosis; Tomography	1979
Relapsing meningoencephalitis ? cerebral sarcoidosis. Proceedings of the Royal Society of Medicine, 1975, Volume: 68, Issue:9 Topics: Adrenocorticotropic Hormone; Adult; Aminosalicylic Acids; Brain Diseases; Dexamethasone; Diagnosis,	1975
[Myoclonic encephalopathy caused by isoniazid-hydantoin combination]. Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1979, Volume: 24, Issue:1 Topics: Brain Diseases; Drug Therapy, Combination; Female; Humans; Isoniazid; Middle Aged; Myoclonus; Phenyt	1979
Five cases of intracranial tuberculoma followed by serial computerised tomography. Journal of neurology, neurosurgery, and psychiatry, 1979, Volume: 42, Issue:4 Topics: Adult; Brain Diseases; Ethambutol; Female; Humans; Isoniazid; Male; Middle Aged; Rifampin; Tomograph	1979
[Electroencephalographic criteria for disorders in the functional state of the central nervous system in pulmonary tuberculosis patients undergoing intensive isoniazid therapy]. Problemy tuberkuleza, 1976, Issue:10 Topics: Adolescent; Adult; Brain Diseases; Electroencephalography; Female; Humans; Isoniazid; Male; Middle A	1976
Synthesis of 2-[123I and 124I]-iodoisonicotinic acid hydrazide--potential radiotracers for tuberculosis. International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, 1991, Volume: 42, Issue:3 Topics: Animals; Biological Availability; Brain Diseases; Iodine Radioisotopes; Isoniazid; Isonicotinic Acid	1991
Central nervous system tuberculosis in children: a review of 30 cases. The Pediatric infectious disease journal, 1990, Volume: 9, Issue:8 Topics: Brain Diseases; Child, Preschool; Drug Resistance, Microbial; Ethnicity; Female; Humans; Hydrocephal	1990
Brain stem tuberculoma in adult patients: diagnosis and treatment. Surgical neurology, 1990, Volume: 34, Issue:6 Topics: Adult; Brain Diseases; Drug Therapy, Combination; Humans; Isoniazid; Male; Middle Aged; Pyrazinamide	1990
Non-surgical treatment of tuberculomas of the brain. British journal of neurosurgery, 1989, Volume: 3, Issue:6 Topics: Adult; Antitubercular Agents; Brain Diseases; Drug Combinations; Female; Humans; Isoniazid; Male; Mi	1989
Pellagra encephalopathy among tuberculous patients: its relation to isoniazid therapy. Journal of neurology, neurosurgery, and psychiatry, 1985, Volume: 48, Issue:7 Topics: Adult; Aged; Brain; Brain Diseases; Drug Therapy, Combination; Humans; Isoniazid; Male; Middle Aged;	1985
[A case report of intracerebral tuberculoma during antituberculous therapy]. No shinkei geka. Neurological surgery, 1985, Volume: 13, Issue:9 Topics: Adolescent; Aminosalicylic Acid; Brain Diseases; Combined Modality Therapy; Drug Therapy, Combinatio	1985
[Minute structure of spongious dystrophy of the grey matter]. Verhandlungen der Deutschen Gesellschaft fur Pathologie, 1968, Volume: 52 Topics: Animals; Brain Diseases; Cerebral Cortex; Columbidae; Humans; Infant; Isoniazid; Male; Methionine Su	1968
Supratentorial tuberculoma: a case report and review. Bulletin of the Los Angeles neurological societies, 1974, Volume: 39, Issue:2 Topics: Adult; Brain Diseases; Cerebral Angiography; Dexamethasone; Diagnosis, Differential; Electroencephal	1974
Reversible pellagra-like encephalopathy with ethionamide and cycloserine. Tubercle, 1972, Volume: 53, Issue:2 Topics: Brain Diseases; Cycloserine; Ethionamide; Female; Humans; Isoniazid; Male; Middle Aged; Niacinamide;	1972
Three patients with intracranial tuberculomas with unusual features. Journal of neurology, neurosurgery, and psychiatry, 1974, Volume: 37, Issue:5 Topics: Adolescent; Aminosalicylic Acids; Brain Diseases; Dexamethasone; Diabetic Coma; Electroencephalograp	1974
[Autohistioradiographic studies on the problem of the blood-brain barrier in experimentally induced spongious encephalopathies]. Virchows Archiv. A, Pathology. Pathologische Anatomie, 1968, Volume: 345, Issue:4 Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Diseases; Columbidae; Ducks; Isoniazid;	1968
[Intracranial tuberculosis: yesterday and today]. Wiener medizinische Wochenschrift (1946), 1970, Nov-21, Volume: 120, Issue:47 Topics: Adolescent; Age Factors; Aminosalicylic Acids; Brain Diseases; Child; Female; Humans; India; Isoniaz	1970
Encephalopathy following accidental isoniazid poisoning. Clinical pediatrics, 1971, Volume: 10, Issue:6 Topics: Brain Chemistry; Brain Diseases; Child, Preschool; Humans; Isoniazid; Male; Phenobarbital; Pyridoxin	1971
[Harmful effects of isoniazid on the fetus and infants]. Lyon medical, 1967, Sep-17, Volume: 217, Issue:38 Topics: Brain Diseases; Child, Preschool; Female; Fetal Diseases; Fetus; Humans; Infant; Infant, Newborn; In	1967
Systemic (cerebral) chromoblastomycosis: diagnosis during life, drug sensitivities, and treatment of a single case. Neurology, 1968, Volume: 18, Issue:3 Topics: Adult; Amphotericin B; Brain Diseases; Chromoblastomycosis; Diagnosis, Differential; Female; Humans;	1968
[On the ultrastructure of INH-encephallopathy in the duck]. Klinische Wochenschrift, 1968, Oct-01, Volume: 46, Issue:19 Topics: Animals; Brain Diseases; Ducks; Ganglia; Isoniazid; Poultry Diseases	1968
Fungal infecton of central nervous system supervening during routine chemotherapy for pulmonary tuberculosis. British medical journal, 1965, Oct-09, Volume: 2, Issue:5466 Topics: Aminosalicylic Acids; Aspergillosis; Brain Diseases; Central Nervous System Diseases; Humans; Isonia	1965
Isonicotinic acid hydrazide-induced spongy degeneration of the white matter in the brains of Pekin ducks. The American journal of pathology, 1966, Volume: 48, Issue:1 Topics: Animals; Ataxia; Axons; Brain Diseases; Demyelinating Diseases; Isoniazid; Neuroglia; Poultry; Tremo	1966

isoniazid and Brain Disorders

Research Excerpts

Research

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