isoniazid has been researched along with Asymptomatic Conditions in 1 studies
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Danel, C | 1 |
Moh, R | 1 |
Gabillard, D | 1 |
Badje, A | 1 |
Le Carrou, J | 1 |
Ouassa, T | 1 |
Ouattara, E | 1 |
Anzian, A | 1 |
Ntakpé, JB | 1 |
Minga, A | 1 |
Kouame, GM | 1 |
Bouhoussou, F | 1 |
Emieme, A | 1 |
Kouamé, A | 2 |
Inwoley, A | 1 |
Toni, TD | 1 |
Ahiboh, H | 1 |
Kabran, M | 1 |
Rabe, C | 1 |
Sidibé, B | 1 |
Nzunetu, G | 1 |
Konan, R | 1 |
Gnokoro, J | 1 |
Gouesse, P | 1 |
Messou, E | 1 |
Dohoun, L | 1 |
Kamagate, S | 1 |
Yao, A | 1 |
Amon, S | 1 |
Kouame, AB | 1 |
Koua, A | 1 |
Kouamé, E | 1 |
Ndri, Y | 1 |
Ba-Gomis, O | 1 |
Daligou, M | 1 |
Ackoundzé, S | 1 |
Hawerlander, D | 1 |
Ani, A | 1 |
Dembélé, F | 1 |
Koné, F | 1 |
Guéhi, C | 1 |
Kanga, C | 1 |
Koule, S | 1 |
Séri, J | 1 |
Oyebi, M | 1 |
Mbakop, N | 1 |
Makaila, O | 1 |
Babatunde, C | 1 |
Babatounde, N | 1 |
Bleoué, G | 1 |
Tchoutedjem, M | 1 |
Kouadio, AC | 1 |
Sena, G | 1 |
Yededji, SY | 1 |
Assi, R | 1 |
Bakayoko, A | 1 |
Mahassadi, A | 1 |
Attia, A | 1 |
Oussou, A | 1 |
Mobio, M | 1 |
Bamba, D | 1 |
Koman, M | 1 |
Horo, A | 1 |
Deschamps, N | 1 |
Chenal, H | 1 |
Sassan-Morokro, M | 1 |
Konate, S | 1 |
Aka, K | 1 |
Aoussi, E | 1 |
Journot, V | 1 |
Nchot, C | 1 |
Karcher, S | 1 |
Chaix, ML | 1 |
Rouzioux, C | 1 |
Sow, PS | 1 |
Perronne, C | 1 |
Girard, PM | 1 |
Menan, H | 1 |
Bissagnene, E | 1 |
Kadio, A | 1 |
Ettiegne-Traore, V | 1 |
Moh-Semdé, C | 1 |
Massumbuko, JM | 1 |
Chêne, G | 1 |
Dosso, M | 1 |
Domoua, SK | 1 |
N'Dri-Yoman, T | 1 |
Salamon, R | 1 |
Eholié, SP | 1 |
Anglaret, X | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Multicenter Clinical Trial to Evaluate the Feasibility and Outcome of Same-day Antiretroviral Therapy With Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/F/TAF) Among Patients Testing Positive by HIV Confirmatory Tests[NCT04712058] | 200 participants (Anticipated) | Interventional | 2021-01-20 | Recruiting | |||
Options for Delivering Isoniazid-Rifapentine (3HP) for TB Prevention: the 3HP Options Implementation Trial[NCT03934931] | 1,656 participants (Actual) | Interventional | 2020-07-13 | Active, not recruiting | |||
Benefits and Risks of Early Antiretroviral Therapy in HIV-infected Adults in Abidjan, Côte d'Ivoire: Randomized Controlled Trial (ANRS 12136 TEMPRANO)[NCT00495651] | Phase 3 | 2,073 participants (Actual) | Interventional | 2008-03-31 | Completed | ||
Same Day Community-based ART Initiation Versus Clinic-based Pre-ART Assessment and Counselling for Individuals Newly Tested HIV-positive During Community-based HIV Testing in Rural Lesotho - a Randomized Controlled Trial[NCT02692027] | Phase 3 | 276 participants (Actual) | Interventional | 2016-02-29 | Completed | ||
PROvide MIner-friendly SErvices for Integrated TB/HIV Care in Lesotho Study (PROMISE Study)[NCT03537872] | 248 participants (Actual) | Interventional | 2018-03-13 | Completed | |||
URBAN ARCH (3/5) Uganda Cohort TB Preventive Therapy for HIV-infected Alcohol Users in Uganda: an Evaluation of Safety Tolerability and Adherence[NCT03302299] | Phase 4 | 302 participants (Actual) | Interventional | 2017-04-07 | Completed | ||
TB Screening Improves Preventive Therapy Uptake Trial[NCT04557176] | 1,719 participants (Actual) | Interventional | 2020-11-16 | Active, not recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
The count of eligible people living with HIV (PLHIV) offered 3HP who accept to initiate treatment (by age, gender, CD4 stratum, viral load suppression) divided by the count of those randomized. (NCT03934931)
Timeframe: Within 16 weeks of treatment initiation
Intervention | proportion of participants (Number) |
---|---|
Facilitated Directly Observed Therapy (DOT) | 0.998 |
Facilitated Self-Administered Therapy (SAT) | 1.00 |
Patient Choice Between Facilitated DOT and Facilitated SAT | 0.995 |
The count of eligible participants who accept treatment and take at least 11 of 12 once weekly doses of rifapentine (RPT)/isoniazid (INH) within 16 weeks of treatment initiation divided by the count of those randomized. (NCT03934931)
Timeframe: Within 16 weeks of treatment initiation
Intervention | proportion of participants (Number) |
---|---|
Facilitated Directly Observed Therapy (DOT) | 0.946 |
Facilitated Self-Administered Therapy (SAT) | 0.922 |
Patient Choice Between Facilitated DOT and Facilitated SAT | 0.944 |
Count of participants who take at least 11 of 12 doses within 16 weeks of treatment initiation divided by the count those who take at least one dose of 3HP. (NCT03934931)
Timeframe: Within 16 weeks of treatment initiation
Intervention | proportion of participants (Number) |
---|---|
Facilitated Directly Observed Therapy (DOT) | 0.947 |
Facilitated Self-Administered Therapy (SAT) | 0.922 |
Patient Choice Between Facilitated DOT and Facilitated SAT | 0.949 |
Count of participants for whom treatment is discontinued due to adverse events or intolerance divided by the count of those who initiated 3HP. (NCT03934931)
Timeframe: Within 16 weeks of treatment initiation
Intervention | proportion of participants (Number) |
---|---|
Facilitated Directly Observed Therapy (DOT) | 0.0054 |
Facilitated Self-Administered Therapy (SAT) | 0.013 |
Patient Choice Between Facilitated DOT and Facilitated SAT | 0.0073 |
Safety will be assessed by the occurrence of a Grade 3/4 hepatotoxicity at any time during the assigned treatment period. (NCT03302299)
Timeframe: Hepatotoxicity occurring during the six month course (180 pills) of isoniazid (INH), which may be taken over a maximum of 9 months.
Intervention | percent (Number) |
---|---|
INH and Vitamin B6 | 8.3 |
Lack of tolerability will be defined as any isoniazid (INH) treatment discontinuation prior to completion of the prescribed course (6 months of INH taken over a maximum period of 9 months) due to side effects or alanine transaminase (ALT)/aspartate transaminase (AST) elevations. (NCT03302299)
Timeframe: Six month course (180 pills) of isoniazid (INH), which may be taken over a maximum of 9 months.
Intervention | Participants (Count of Participants) |
---|---|
INH and Vitamin B6 | 32 |
Alanine transaminase (ALT) or aspartate transaminase (AST) elevations (>2x the upper limit of normal) at study screening (NCT03302299)
Timeframe: Study screening visit
Intervention | Participants (Count of Participants) |
---|---|
Study Screening | 80 |
Latent tuberculosis assessed at screening via tuberculin skin testing (TST). A TST induration >=5mm was considered positive for latent tuberculosis. (NCT03302299)
Timeframe: Study screening visit
Intervention | Participants (Count of Participants) |
---|---|
Study Screening | 308 |
INH concentration in hair (pmol/mg) will be measured at 3- and 6- months during INH therapy. (NCT03302299)
Timeframe: Measured at 3- and 6- months after INH initiation
Intervention | pmol/mg (Median) | |
---|---|---|
at 3 months | at 6 months | |
INH and Vitamin B6 | 36.0 | 37.8 |
Suboptimal INH adherence was defined as <90% of days with at least 1 electronic medication management (EMM) pill cap opening in the previous 90 days, at 3- and 6-months. (NCT03302299)
Timeframe: Adherence will be measured over the 6 months on INH or until INH discontinuation (whichever is shorter)
Intervention | percentage of participants (Number) | |
---|---|---|
at 3 months | at 6 months | |
INH and Vitamin B6 | 31.3 | 43.9 |
"Participants were asked In the past 30 days, how many days in total have you not taken your pill? and were presented with a visual analog scale (VAS) to indicate the percentage of INH taken in the past 30 days. We converted the VAS percentage into number of days out of 30 to match the first question. Our final self-report measure was the minimum number of the 2 self-reported measurements." (NCT03302299)
Timeframe: Self-reported INH medication adherence via VAS will be measured 3- and 6- months after starting INH
Intervention | days (Median) | |
---|---|---|
at 3 months | at 6 months | |
INH and Vitamin B6 | 30 | 30 |
The Self Rating Single Item (SRSI) adherence scale asks participants to rate their ability to take their medications as prescribed over the past 30 days. Participants reporting INH use in the prior 30 days at the 3- or 6-month interview are included here, and reported their INH adherence in the prior 30 days as excellent, very good, good, fair, poor, or very poor. (NCT03302299)
Timeframe: Self-reported INH medication adherence via SRSI will be measured 3- and 6- months after starting INH
Intervention | Participants (Count of Participants) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
At 3 months72558043 | At 6 months72558043 | |||||||||||
Excellent | Very good | Good | Fair | Poor | Very poor | |||||||
INH and Vitamin B6 | 160 | |||||||||||
INH and Vitamin B6 | 79 | |||||||||||
INH and Vitamin B6 | 38 | |||||||||||
INH and Vitamin B6 | 2 | |||||||||||
INH and Vitamin B6 | 124 | |||||||||||
INH and Vitamin B6 | 90 | |||||||||||
INH and Vitamin B6 | 41 | |||||||||||
INH and Vitamin B6 | 4 | |||||||||||
INH and Vitamin B6 | 0 | |||||||||||
INH and Vitamin B6 | 1 |
1 trial available for isoniazid and Asymptomatic Conditions
Article | Year |
---|---|
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antitubercular Agents; Asympto | 2015 |