isoniazid and Aging
isoniazid has been researched along with Aging in 49 studies
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The rise in non-heme iron (NHI) concentration observed in skeletal muscle of aging rodents is thought to contribute to the development of sarcopenia." | 3.79 | Aging-related changes in the iron status of skeletal muscle. ( Cowley, PM; DeRuisseau, KC; DeRuisseau, LR; Doyle, RP; Fazen, CH; Park, YM, 2013) |
| " The onset of isoniazid-induced seizures in LEC rats at 9 weeks of age was significantly delayed compared with that in LE rats." | 3.70 | Increased abundance of GABAA receptor subunit mRNAs in the brain of Long-Evans Cinnamon rats, an animal model of Wilson's disease. ( Biggio, G; Floris, S; Follesa, P; Mallei, A; Mostallino, MC; Sanna, E, 1999) |
| "This study shows that memory immune T lymphocytes, harvested from young (3-month-old) mice infected intravenously with Mycobacterium tuberculosis and then exposed to protracted chemotherapy with isoniazid, are capable of adoptively protecting old (24 month) mice from a subsequent fatal challenge infection." | 3.67 | Aging and immunity to tuberculosis: prolonged survival of old mice infected with Mycobacterium tuberculosis by adoptive immunization with memory-immune T lymphocytes. ( Orme, IM, 1989) |
| "Hence, TE-mediated genomic instability may substantially contribute to the aging process." | 1.46 | The Piwi-piRNA pathway: road to immortality. ( Ivics, Z; Perczel, A; Sturm, Á; Vellai, T, 2017) |
| "Isoniazid treatment increased serum hepatotoxicity markers (alanine and aspartate transaminase) in young animals but not in old animals, and only reached significance with the high dose in young animals." | 1.43 | The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats. ( Cogger, V; de Cabo, R; Hilmer, SN; Huizer-Pajkos, A; Jones, B; Kane, A; Le Couteur, DG; Mach, J; McKenzie, C; Mitchell, SJ; Phillips, L, 2016) |
| "The first order elimination rate constant (k) and area under the concentration curve (AUC) were calculated in 64 children <13 years of age (median 3." | 1.33 | Isoniazid pharmacokinetics in children treated for respiratory tuberculosis. ( Donald, PR; Hesseling, PB; Maritz, JS; Parkin, DP; Schaaf, HS; Seifart, HI; van Helden, PD; Werely, CJ, 2005) |
| "Age-related changes in the expression of xenobiotic biotransformation enzymes can result in differences in the rates of chemical activation and detoxification, affecting responses to the therapeutic and/or toxic effects of chemicals." | 1.32 | Neonatal ontogeny of murine arylamine N-acetyltransferases: implications for arylamine genotoxicity. ( Chau, B; McQueen, CA, 2003) |
| "Family and personal history of mental illness are also predisposing factors." | 1.31 | [Behavioral disorders after treatment with isoniazid]. ( Djibo, A; Lawan, A, 2001) |
| "At isoniazid-induced generalized tonic-clonic seizures, a significant increase in both enzyme activities was observed in adult rat brain." | 1.31 | Influence of convulsants on rat brain activities of alanine aminotransferase and aspartate aminotransferase. ( Drsata, J; Haugvicová, R; Kubová, H; Mares, P; Netopilová, M, 2001) |
| "Motor seizures elicited by isonicotinehydrazide (INH) were studied in 188 male albino rats aged from 5 days to adulthood." | 1.28 | Ontogenetic development of isonicotinehydrazide-induced seizures in rats. ( Mares, P; Trojan, S, 1991) |
| " Elderly patients are more sensitive to antituberculous (anti-TB) drugs; therefore, a modification in the dosage for this patient group should be considered." | 1.28 | The disposition of antituberculous drugs in plasma of elderly patients. II. Isoniazid, rifampicin and pyrazinamide. ( Chan, HS; Chan, K; Walubo, A; Wong, CL; Woo, J, 1991) |
| "The distribution of the acetylator phenotype of isoniazid was studied in 458 patients of different ages, and the influence of age on its apparent distribution volume, clearance and half-life was investigated in slow and rapid acetylators." | 1.27 | Pharmacokinetics of isoniazid: influence of age. ( Bourin, M; Kergueris, MF; Larousse, C, 1986) |
Research
Studies (49)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (30.61) | 18.7374 |
| 1990's | 11 (22.45) | 18.2507 |
| 2000's | 6 (12.24) | 29.6817 |
| 2010's | 15 (30.61) | 24.3611 |
| 2020's | 2 (4.08) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| DeRuisseau, KC | 1 |
| Park, YM | 1 |
| DeRuisseau, LR | 1 |
| Cowley, PM | 1 |
| Fazen, CH | 1 |
| Doyle, RP | 1 |
| Mach, J | 1 |
| Huizer-Pajkos, A | 1 |
| Mitchell, SJ | 1 |
| McKenzie, C | 1 |
| Phillips, L | 1 |
| Kane, A | 1 |
| Jones, B | 1 |
| de Cabo, R | 1 |
| Cogger, V | 1 |
| Le Couteur, DG | 1 |
| Hilmer, SN | 1 |
| Liss, G | 1 |
| Rattan, S | 1 |
| Lewis, JH | 1 |
| McQueen, CA | 1 |
| Chau, B | 1 |
| HEINRICH, F | 1 |
| KELLER, L | 1 |
| RADENBACH, KL | 1 |
| ZELLER, F | 1 |
| KRULIK, R | 1 |
| Schaaf, HS | 1 |
| Parkin, DP | 1 |
| Seifart, HI | 1 |
| Werely, CJ | 1 |
| Hesseling, PB | 1 |
| van Helden, PD | 1 |
| Maritz, JS | 1 |
| Donald, PR | 1 |
| Hammond, EC | 1 |
| Selikoff, IJ | 1 |
| Robitzek, EH | 1 |
| Ochs, HR | 1 |
| Greenblatt, DJ | 1 |
| Verburg-Ochs, B | 1 |
| Harmatz, JS | 1 |
| Grehl, H | 1 |
| Gupta, RC | 1 |
| Nair, CR | 1 |
| Jindal, SK | 1 |
| Malik, SK | 1 |
| van den Brande, P | 1 |
| van Steenbergen, W | 1 |
| Vervoort, G | 1 |
| Demedts, M | 1 |
| Crowe, A | 1 |
| Morgan, EH | 1 |
| Van Asten, JG | 1 |
| Te Koppele, JM | 1 |
| Horbach, GJ | 1 |
| Woo, J | 4 |
| Cheung, W | 2 |
| Chan, R | 2 |
| Chan, HS | 3 |
| Cheng, A | 1 |
| Chan, K | 4 |
| Chan, C | 1 |
| Or, K | 1 |
| Pariente-Khayat, A | 1 |
| Rey, E | 1 |
| Gendrel, D | 1 |
| Vauzelle-Kervroëdan, F | 1 |
| Crémier, O | 1 |
| d'Athis, P | 1 |
| Badoual, J | 1 |
| Olive, G | 1 |
| Pons, G | 1 |
| Follesa, P | 1 |
| Mallei, A | 1 |
| Floris, S | 1 |
| Mostallino, MC | 1 |
| Sanna, E | 1 |
| Biggio, G | 1 |
| Djibo, A | 1 |
| Lawan, A | 1 |
| Netopilová, M | 1 |
| Haugvicová, R | 1 |
| Kubová, H | 1 |
| Drsata, J | 1 |
| Mares, P | 2 |
| Huang, YS | 1 |
| Chern, HD | 1 |
| Su, WJ | 1 |
| Wu, JC | 1 |
| Lai, SL | 1 |
| Yang, SY | 1 |
| Chang, FY | 1 |
| Lee, SD | 1 |
| Farah, F | 1 |
| Taylor, W | 1 |
| Rawlins, MD | 1 |
| James, O | 1 |
| Frater-Schröder, M | 1 |
| Zbinden, G | 1 |
| Trojan, S | 1 |
| Walubo, A | 2 |
| Wong, CL | 2 |
| Orme, IM | 1 |
| Kergueris, MF | 1 |
| Bourin, M | 1 |
| Larousse, C | 1 |
| Gachályi, B | 1 |
| Vas, A | 1 |
| Káldor, A | 1 |
| Williams, MH | 1 |
| Deshmukh, A | 1 |
| Deshmukh, K | 1 |
| Nimni, ME | 1 |
| Rogers, WF | 1 |
| Mercer, NH | 1 |
| Bowen, PP | 1 |
| Johnston, FA | 1 |
| Sun, S | 1 |
| White, RR | 1 |
| Fischer, KE | 1 |
| Zhang, Z | 1 |
| Austad, SN | 1 |
| Vijg, J | 1 |
| Mikuła-Pietrasik, J | 1 |
| Pakuła, M | 1 |
| Markowska, M | 1 |
| Uruski, P | 1 |
| Szczepaniak-Chicheł, L | 1 |
| Tykarski, A | 1 |
| Książek, K | 1 |
| Sturm, Á | 1 |
| Perczel, A | 1 |
| Ivics, Z | 1 |
| Vellai, T | 1 |
| Mortzfeld, BM | 1 |
| Bosch, TC | 2 |
| Davy, PMC | 1 |
| Allsopp, RC | 1 |
| Donlon, TA | 1 |
| Morris, BJ | 1 |
| Willcox, DC | 1 |
| Willcox, BJ | 1 |
| Klimovich, A | 1 |
| Rehm, A | 1 |
| Wittlieb, J | 1 |
| Herbst, EM | 1 |
| Benavente, R | 1 |
| Bosch, TCG | 2 |
| Tomczyk, S | 1 |
| Buzgariu, W | 1 |
| Perruchoud, C | 1 |
| Fisher, K | 1 |
| Austad, S | 1 |
| Galliot, B | 1 |
| Boehm, AM | 1 |
| Rosenstiel, P | 1 |
| Petralia, RS | 1 |
| Mattson, MP | 1 |
| Yao, PJ | 1 |
| Schaible, R | 2 |
| Sussman, M | 1 |
| Kramer, BH | 2 |
| Estep, PW | 1 |
| Ringelhan, F | 1 |
| Miethe, T | 1 |
| Martínez, DE | 2 |
| Bridge, D | 1 |
| Gems, D | 1 |
| Zamaraev, VN | 1 |
Reviews
8 reviews available for isoniazid and Aging
| Article | Year |
|---|---|
Predicting and preventing acute drug-induced liver injury: what's new in 2010?
Topics: Acetaminophen; Adult; Aged; Aging; Alanine Transaminase; Amoxicillin-Potassium Clavulanate Combinati | 2010 |
Nontraditional systems in aging research: an update.
Topics: Aging; Animals; Biological Evolution; Caulobacter crescentus; Elephants; Escherichia coli; Fibroblas | 2021 |
Eco-Aging: stem cells and microbes are controlled by aging antagonist FoxO.
Topics: Aging; Animals; Antimicrobial Cationic Peptides; Cell Proliferation; Ecosystem; Gene Expression Regu | 2017 |
Stem cells and aging from a quasi-immortal point of view.
Topics: Aging; Animals; Apolipoproteins E; Cell Proliferation; Forkhead Transcription Factors; Gene-Environm | 2013 |
Aging and longevity in the simplest animals and the quest for immortality.
Topics: Age Factors; Aging; Animals; Biological Evolution; Ciliophora; Cnidaria; Humans; Hydra; Invertebrate | 2014 |
Aging and potential for self-renewal: hydra living in the age of aging - a mini-review.
Topics: Aging; Animals; Cell Proliferation; Disease Resistance; Hydra; Reproduction, Asexual | 2014 |
Hydra, the everlasting embryo, confronts aging.
Topics: Aging; Animals; HSP70 Heat-Shock Proteins; Hydra; Insulin; Insulin-Like Growth Factor I; JNK Mitogen | 2012 |
Does regenerative capacity decrease with age?
Topics: Aging; Ambystoma; Animals; Anura; Astacoidea; Birds; Brachyura; Cnidaria; Cockroaches; Coleoptera; D | 1974 |
Trials
1 trial available for isoniazid and Aging
| Article | Year |
|---|---|
Correlation between steady-state plasma concentration of antituberculous drugs and age, inclusion of rifampicin in the treatment regimen, adverse drug reactions and other clinical parameters.
Topics: Adult; Aged; Aging; Antitubercular Agents; Female; Homeostasis; Humans; Isoniazid; Male; Middle Aged | 1995 |
Other Studies
40 other studies available for isoniazid and Aging
| Article | Year |
|---|---|
Aging-related changes in the iron status of skeletal muscle.
Topics: Aging; Animals; Cation Transport Proteins; Ferritins; Gene Expression; Heme; Iron; Iron Chelating Ag | 2013 |
The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats.
Topics: Aging; Animals; Antitubercular Agents; Biomarkers; Chemical and Drug Induced Liver Injury; Dose-Resp | 2016 |
Neonatal ontogeny of murine arylamine N-acetyltransferases: implications for arylamine genotoxicity.
Topics: 4-Aminobenzoic Acid; Acetyltransferases; Aging; Amino Acid Transport System A; Amino Acid Transport | 2003 |
[ON MAMMARY TUBERCULOSIS AND ITS PRESENT TREATMENT].
Topics: Aging; Aminosalicylic Acid; Aminosalicylic Acids; Breast Diseases; Humans; Isoniazid; Mastectomy; St | 1963 |
[The effect of isoniazid on glucide metabolism. III. The relation between the pyruvic acid and alpha-ketoglutaric acid concentrations in the rat liver and the level of isoniazid administration. The influence of the age of the experimental animal on the is
Topics: Aging; Animals; Isoniazid; Keto Acids; Ketoglutaric Acids; Liver; Pyruvates; Pyruvic Acid; Rats | 1962 |
Isoniazid pharmacokinetics in children treated for respiratory tuberculosis.
Topics: Adolescent; Adult; Aging; Analysis of Variance; Antitubercular Agents; Area Under Curve; Arylamine N | 2005 |
Isoniazid therapy in relation to later occurrence of cancer in adults and in infants.
Topics: Adult; Aged; Aging; Carcinogens; Child; Child, Preschool; Female; Fetal Death; Fetal Diseases; Human | 1967 |
Disposition of clotiazepam: influence of age, sex, oral contraceptives, cimetidine, isoniazid and ethanol.
Topics: Adult; Aged; Aging; Azepines; Cimetidine; Contraceptives, Oral, Hormonal; Drug Interactions; Ethanol | 1984 |
Incidence of isoniazid acetylation phenotypes in North Indians.
Topics: Acetylation; Adult; Aging; Alcohol Drinking; Female; Humans; India; Isoniazid; Kinetics; Male; Middl | 1984 |
Aging and hepatotoxicity of isoniazid and rifampin in pulmonary tuberculosis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alanine Transaminase; Aspartate Aminotransferases | 1995 |
Effects of chelators on iron uptake and release by the brain in the rat.
Topics: 2,2'-Dipyridyl; Aging; Animals; Biological Transport; Bone and Bones; Brain; Deferiprone; Deferoxami | 1994 |
The influence of aging on dimethylnitrosamine-demethylase enzyme kinetics in rat liver microsomes.
Topics: Aging; Animals; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Glutathione Transferase; Is | 1995 |
In vitro protein binding characteristics of isoniazid, rifampicin, and pyrazinamide to whole plasma, albumin, and alpha-1-acid glycoprotein.
Topics: Aging; Blood Proteins; Humans; In Vitro Techniques; Isoniazid; Orosomucoid; Plasma; Protein Binding; | 1996 |
Isoniazid acetylation metabolic ratio during maturation in children.
Topics: Acetylation; Adolescent; Aging; Antitubercular Agents; Arylamine N-Acetyltransferase; Child; Child, | 1997 |
Increased abundance of GABAA receptor subunit mRNAs in the brain of Long-Evans Cinnamon rats, an animal model of Wilson's disease.
Topics: Aging; Analysis of Variance; Animals; Disease Models, Animal; Hepatolenticular Degeneration; Isoniaz | 1999 |
[Behavioral disorders after treatment with isoniazid].
Topics: Aging; Alcoholism; Antitubercular Agents; Behavior; Contraindications; Diabetes Mellitus; Female; Hu | 2001 |
Influence of convulsants on rat brain activities of alanine aminotransferase and aspartate aminotransferase.
Topics: 3-Mercaptopropionic Acid; Aging; Alanine Transaminase; Animals; Aspartate Aminotransferases; Brain; | 2001 |
Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis.
Topics: Acetylation; Aged; Aging; Antitubercular Agents; Arylamine N-Acetyltransferase; Chemical and Drug In | 2002 |
Hepatic drug acetylation and oxidation: effects of aging in man.
Topics: Acetanilides; Acetylation; Adolescent; Adult; Aged; Aging; Half-Life; Humans; Isoniazid; Liver; Oxid | 1977 |
A specific rapid gaschromatographic assay for the determination of isoniazid N-acetylation: observation in rats with induced constant urine flow.
Topics: Aging; Animals; Chromatography, Gas; Diuresis; Isoniazid; Rats | 1975 |
Ontogenetic development of isonicotinehydrazide-induced seizures in rats.
Topics: Aging; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Isoniazid; Male; Motor Activ | 1991 |
The disposition of antituberculous drugs in plasma of elderly patients. I. Isoniazid and hydrazine metabolite.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Isoniazid; Male; Middle Aged; Py | 1991 |
The disposition of antituberculous drugs in plasma of elderly patients. II. Isoniazid, rifampicin and pyrazinamide.
Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Isoniazid; Male; Metabolic Clearance Rate; Mi | 1991 |
Aging and immunity to tuberculosis: prolonged survival of old mice infected with Mycobacterium tuberculosis by adoptive immunization with memory-immune T lymphocytes.
Topics: Aging; Animals; Female; Immunization, Passive; Immunologic Memory; Isoniazid; Mice; Mice, Inbred C57 | 1989 |
Pharmacokinetics of isoniazid: influence of age.
Topics: Acetylation; Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Female; Half-Life; Humans; Inf | 1986 |
Ageing and acetylator phenotype.
Topics: Acetylation; Aged; Aging; Female; Humans; Isoniazid; Male; Middle Aged; Pharmaceutical Preparations; | 1985 |
Special problems in respiratory diseases.
Topics: Adrenal Cortex Hormones; Aged; Aging; Anti-Bacterial Agents; Anticoagulants; Asthma; Bronchodilator | 1974 |
Synthesis of aldehydes and their interactions during the in vitro aging of collagen.
Topics: Acetates; Adipates; Aging; Aldehydes; Amines; Amino Acid Oxidoreductases; Aminopropionitrile; Animal | 1971 |
Some aspects of pulmonary tuberculosis in older patients.
Topics: Aged; Aging; Aminosalicylic Acids; Drug Combinations; Female; Humans; Isoniazid; Male; Radiography; | 1972 |
Effect of age, vitamin B6 deficiency, isoniazid and deoxypyridoxine on the urinary taurine of the rat.
Topics: Aging; Animals; Isoniazid; Pyridoxine; Rats; Taurine; Vitamin B 6 Deficiency | 1966 |
Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways.
Topics: Aging; Animals; Hydra; Male; Reproduction; Reproduction, Asexual; Stem Cells | 2020 |
The Piwi-piRNA pathway: road to immortality.
Topics: Aging; Animals; CRISPR-Cas Systems; DNA Transposable Elements; Drosophila melanogaster; Gene Express | 2017 |
FOXO3 and Exceptional Longevity: Insights From Hydra to Humans.
Topics: Aging; Animals; Forkhead Box Protein O3; Genome-Wide Association Study; Humans; Hydra; Longevity; Po | 2018 |
Non-senescent
Topics: Aging; Animals; Cellular Senescence; Hydra; Lamins; Longevity; Nuclear Lamina; Stem Cells | 2018 |
Hydra as Model to Determine the Role of FOXO in Longevity.
Topics: Aging; Animals; Animals, Genetically Modified; Forkhead Transcription Factors; Gene Expression Profi | 2019 |
Loss of Neurogenesis in Aging Hydra.
Topics: Aging; Animals; Cold Temperature; Eating; Gene Expression; Hydra; Movement; Nerve Degeneration; Neur | 2019 |
Declining asexual reproduction is suggestive of senescence in hydra: comment on Martinez, D., "Mortality patterns suggest lack of senescence in hydra." Exp Gerontol 33, 217-25.
Topics: Aging; Animals; Hydra; Reproduction | 2010 |
Environmental challenges improve resource utilization for asexual reproduction and maintenance in hydra.
Topics: Aging; Animals; Aphids; Biological Evolution; Genetics, Population; Hydra; Longevity; Models, Geneti | 2011 |
Mortality patterns suggest lack of senescence in hydra.
Topics: Aging; Animals; Hydra; Mortality; Reproduction | 1998 |
An integrated theory of ageing in the nematode Caenorhabditis elegans.
Topics: Aging; Animals; Biological Clocks; Biological Evolution; Caenorhabditis elegans; DNA Damage; Gene Ex | 2000 |