Page last updated: 2024-10-29

isoniazid and Aging

isoniazid has been researched along with Aging in 49 studies

Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The rise in non-heme iron (NHI) concentration observed in skeletal muscle of aging rodents is thought to contribute to the development of sarcopenia."3.79Aging-related changes in the iron status of skeletal muscle. ( Cowley, PM; DeRuisseau, KC; DeRuisseau, LR; Doyle, RP; Fazen, CH; Park, YM, 2013)
" The onset of isoniazid-induced seizures in LEC rats at 9 weeks of age was significantly delayed compared with that in LE rats."3.70Increased abundance of GABAA receptor subunit mRNAs in the brain of Long-Evans Cinnamon rats, an animal model of Wilson's disease. ( Biggio, G; Floris, S; Follesa, P; Mallei, A; Mostallino, MC; Sanna, E, 1999)
"This study shows that memory immune T lymphocytes, harvested from young (3-month-old) mice infected intravenously with Mycobacterium tuberculosis and then exposed to protracted chemotherapy with isoniazid, are capable of adoptively protecting old (24 month) mice from a subsequent fatal challenge infection."3.67Aging and immunity to tuberculosis: prolonged survival of old mice infected with Mycobacterium tuberculosis by adoptive immunization with memory-immune T lymphocytes. ( Orme, IM, 1989)
"Hence, TE-mediated genomic instability may substantially contribute to the aging process."1.46The Piwi-piRNA pathway: road to immortality. ( Ivics, Z; Perczel, A; Sturm, Á; Vellai, T, 2017)
"Isoniazid treatment increased serum hepatotoxicity markers (alanine and aspartate transaminase) in young animals but not in old animals, and only reached significance with the high dose in young animals."1.43The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats. ( Cogger, V; de Cabo, R; Hilmer, SN; Huizer-Pajkos, A; Jones, B; Kane, A; Le Couteur, DG; Mach, J; McKenzie, C; Mitchell, SJ; Phillips, L, 2016)
"The first order elimination rate constant (k) and area under the concentration curve (AUC) were calculated in 64 children <13 years of age (median 3."1.33Isoniazid pharmacokinetics in children treated for respiratory tuberculosis. ( Donald, PR; Hesseling, PB; Maritz, JS; Parkin, DP; Schaaf, HS; Seifart, HI; van Helden, PD; Werely, CJ, 2005)
"Age-related changes in the expression of xenobiotic biotransformation enzymes can result in differences in the rates of chemical activation and detoxification, affecting responses to the therapeutic and/or toxic effects of chemicals."1.32Neonatal ontogeny of murine arylamine N-acetyltransferases: implications for arylamine genotoxicity. ( Chau, B; McQueen, CA, 2003)
"Family and personal history of mental illness are also predisposing factors."1.31[Behavioral disorders after treatment with isoniazid]. ( Djibo, A; Lawan, A, 2001)
"At isoniazid-induced generalized tonic-clonic seizures, a significant increase in both enzyme activities was observed in adult rat brain."1.31Influence of convulsants on rat brain activities of alanine aminotransferase and aspartate aminotransferase. ( Drsata, J; Haugvicová, R; Kubová, H; Mares, P; Netopilová, M, 2001)
"Motor seizures elicited by isonicotinehydrazide (INH) were studied in 188 male albino rats aged from 5 days to adulthood."1.28Ontogenetic development of isonicotinehydrazide-induced seizures in rats. ( Mares, P; Trojan, S, 1991)
" Elderly patients are more sensitive to antituberculous (anti-TB) drugs; therefore, a modification in the dosage for this patient group should be considered."1.28The disposition of antituberculous drugs in plasma of elderly patients. II. Isoniazid, rifampicin and pyrazinamide. ( Chan, HS; Chan, K; Walubo, A; Wong, CL; Woo, J, 1991)
"The distribution of the acetylator phenotype of isoniazid was studied in 458 patients of different ages, and the influence of age on its apparent distribution volume, clearance and half-life was investigated in slow and rapid acetylators."1.27Pharmacokinetics of isoniazid: influence of age. ( Bourin, M; Kergueris, MF; Larousse, C, 1986)

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-199015 (30.61)18.7374
1990's11 (22.45)18.2507
2000's6 (12.24)29.6817
2010's15 (30.61)24.3611
2020's2 (4.08)2.80

Authors

AuthorsStudies
DeRuisseau, KC1
Park, YM1
DeRuisseau, LR1
Cowley, PM1
Fazen, CH1
Doyle, RP1
Mach, J1
Huizer-Pajkos, A1
Mitchell, SJ1
McKenzie, C1
Phillips, L1
Kane, A1
Jones, B1
de Cabo, R1
Cogger, V1
Le Couteur, DG1
Hilmer, SN1
Liss, G1
Rattan, S1
Lewis, JH1
McQueen, CA1
Chau, B1
HEINRICH, F1
KELLER, L1
RADENBACH, KL1
ZELLER, F1
KRULIK, R1
Schaaf, HS1
Parkin, DP1
Seifart, HI1
Werely, CJ1
Hesseling, PB1
van Helden, PD1
Maritz, JS1
Donald, PR1
Hammond, EC1
Selikoff, IJ1
Robitzek, EH1
Ochs, HR1
Greenblatt, DJ1
Verburg-Ochs, B1
Harmatz, JS1
Grehl, H1
Gupta, RC1
Nair, CR1
Jindal, SK1
Malik, SK1
van den Brande, P1
van Steenbergen, W1
Vervoort, G1
Demedts, M1
Crowe, A1
Morgan, EH1
Van Asten, JG1
Te Koppele, JM1
Horbach, GJ1
Woo, J4
Cheung, W2
Chan, R2
Chan, HS3
Cheng, A1
Chan, K4
Chan, C1
Or, K1
Pariente-Khayat, A1
Rey, E1
Gendrel, D1
Vauzelle-Kervroëdan, F1
Crémier, O1
d'Athis, P1
Badoual, J1
Olive, G1
Pons, G1
Follesa, P1
Mallei, A1
Floris, S1
Mostallino, MC1
Sanna, E1
Biggio, G1
Djibo, A1
Lawan, A1
Netopilová, M1
Haugvicová, R1
Kubová, H1
Drsata, J1
Mares, P2
Huang, YS1
Chern, HD1
Su, WJ1
Wu, JC1
Lai, SL1
Yang, SY1
Chang, FY1
Lee, SD1
Farah, F1
Taylor, W1
Rawlins, MD1
James, O1
Frater-Schröder, M1
Zbinden, G1
Trojan, S1
Walubo, A2
Wong, CL2
Orme, IM1
Kergueris, MF1
Bourin, M1
Larousse, C1
Gachályi, B1
Vas, A1
Káldor, A1
Williams, MH1
Deshmukh, A1
Deshmukh, K1
Nimni, ME1
Rogers, WF1
Mercer, NH1
Bowen, PP1
Johnston, FA1
Sun, S1
White, RR1
Fischer, KE1
Zhang, Z1
Austad, SN1
Vijg, J1
Mikuła-Pietrasik, J1
Pakuła, M1
Markowska, M1
Uruski, P1
Szczepaniak-Chicheł, L1
Tykarski, A1
Książek, K1
Sturm, Á1
Perczel, A1
Ivics, Z1
Vellai, T1
Mortzfeld, BM1
Bosch, TC2
Davy, PMC1
Allsopp, RC1
Donlon, TA1
Morris, BJ1
Willcox, DC1
Willcox, BJ1
Klimovich, A1
Rehm, A1
Wittlieb, J1
Herbst, EM1
Benavente, R1
Bosch, TCG2
Tomczyk, S1
Buzgariu, W1
Perruchoud, C1
Fisher, K1
Austad, S1
Galliot, B1
Boehm, AM1
Rosenstiel, P1
Petralia, RS1
Mattson, MP1
Yao, PJ1
Schaible, R2
Sussman, M1
Kramer, BH2
Estep, PW1
Ringelhan, F1
Miethe, T1
Martínez, DE2
Bridge, D1
Gems, D1
Zamaraev, VN1

Reviews

8 reviews available for isoniazid and Aging

ArticleYear
Predicting and preventing acute drug-induced liver injury: what's new in 2010?
    Expert opinion on drug metabolism & toxicology, 2010, Volume: 6, Issue:9

    Topics: Acetaminophen; Adult; Aged; Aging; Alanine Transaminase; Amoxicillin-Potassium Clavulanate Combinati

2010
Nontraditional systems in aging research: an update.
    Cellular and molecular life sciences : CMLS, 2021, Volume: 78, Issue:4

    Topics: Aging; Animals; Biological Evolution; Caulobacter crescentus; Elephants; Escherichia coli; Fibroblas

2021
Eco-Aging: stem cells and microbes are controlled by aging antagonist FoxO.
    Current opinion in microbiology, 2017, Volume: 38

    Topics: Aging; Animals; Antimicrobial Cationic Peptides; Cell Proliferation; Ecosystem; Gene Expression Regu

2017
Stem cells and aging from a quasi-immortal point of view.
    BioEssays : news and reviews in molecular, cellular and developmental biology, 2013, Volume: 35, Issue:11

    Topics: Aging; Animals; Apolipoproteins E; Cell Proliferation; Forkhead Transcription Factors; Gene-Environm

2013
Aging and longevity in the simplest animals and the quest for immortality.
    Ageing research reviews, 2014, Volume: 16

    Topics: Age Factors; Aging; Animals; Biological Evolution; Ciliophora; Cnidaria; Humans; Hydra; Invertebrate

2014
Aging and potential for self-renewal: hydra living in the age of aging - a mini-review.
    Gerontology, 2014, Volume: 60, Issue:6

    Topics: Aging; Animals; Cell Proliferation; Disease Resistance; Hydra; Reproduction, Asexual

2014
Hydra, the everlasting embryo, confronts aging.
    The International journal of developmental biology, 2012, Volume: 56, Issue:6-8

    Topics: Aging; Animals; HSP70 Heat-Shock Proteins; Hydra; Insulin; Insulin-Like Growth Factor I; JNK Mitogen

2012
Does regenerative capacity decrease with age?
    The Soviet journal of developmental biology, 1974, Volume: 4, Issue:6

    Topics: Aging; Ambystoma; Animals; Anura; Astacoidea; Birds; Brachyura; Cnidaria; Cockroaches; Coleoptera; D

1974

Trials

1 trial available for isoniazid and Aging

ArticleYear
Correlation between steady-state plasma concentration of antituberculous drugs and age, inclusion of rifampicin in the treatment regimen, adverse drug reactions and other clinical parameters.
    Journal of medicine, 1995, Volume: 26, Issue:5-6

    Topics: Adult; Aged; Aging; Antitubercular Agents; Female; Homeostasis; Humans; Isoniazid; Male; Middle Aged

1995

Other Studies

40 other studies available for isoniazid and Aging

ArticleYear
Aging-related changes in the iron status of skeletal muscle.
    Experimental gerontology, 2013, Volume: 48, Issue:11

    Topics: Aging; Animals; Cation Transport Proteins; Ferritins; Gene Expression; Heme; Iron; Iron Chelating Ag

2013
The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats.
    Fundamental & clinical pharmacology, 2016, Volume: 30, Issue:1

    Topics: Aging; Animals; Antitubercular Agents; Biomarkers; Chemical and Drug Induced Liver Injury; Dose-Resp

2016
Neonatal ontogeny of murine arylamine N-acetyltransferases: implications for arylamine genotoxicity.
    Toxicological sciences : an official journal of the Society of Toxicology, 2003, Volume: 73, Issue:2

    Topics: 4-Aminobenzoic Acid; Acetyltransferases; Aging; Amino Acid Transport System A; Amino Acid Transport

2003
[ON MAMMARY TUBERCULOSIS AND ITS PRESENT TREATMENT].
    Medizinische Klinik, 1963, Dec-06, Volume: 58

    Topics: Aging; Aminosalicylic Acid; Aminosalicylic Acids; Breast Diseases; Humans; Isoniazid; Mastectomy; St

1963
[The effect of isoniazid on glucide metabolism. III. The relation between the pyruvic acid and alpha-ketoglutaric acid concentrations in the rat liver and the level of isoniazid administration. The influence of the age of the experimental animal on the is
    Beitrage zur Klinik der Tuberkulose und spezifischen Tuberkulose-Forschung, 1962, Volume: 125

    Topics: Aging; Animals; Isoniazid; Keto Acids; Ketoglutaric Acids; Liver; Pyruvates; Pyruvic Acid; Rats

1962
Isoniazid pharmacokinetics in children treated for respiratory tuberculosis.
    Archives of disease in childhood, 2005, Volume: 90, Issue:6

    Topics: Adolescent; Adult; Aging; Analysis of Variance; Antitubercular Agents; Area Under Curve; Arylamine N

2005
Isoniazid therapy in relation to later occurrence of cancer in adults and in infants.
    British medical journal, 1967, Jun-24, Volume: 2, Issue:5555

    Topics: Adult; Aged; Aging; Carcinogens; Child; Child, Preschool; Female; Fetal Death; Fetal Diseases; Human

1967
Disposition of clotiazepam: influence of age, sex, oral contraceptives, cimetidine, isoniazid and ethanol.
    European journal of clinical pharmacology, 1984, Volume: 26, Issue:1

    Topics: Adult; Aged; Aging; Azepines; Cimetidine; Contraceptives, Oral, Hormonal; Drug Interactions; Ethanol

1984
Incidence of isoniazid acetylation phenotypes in North Indians.
    International journal of clinical pharmacology, therapy, and toxicology, 1984, Volume: 22, Issue:5

    Topics: Acetylation; Adult; Aging; Alcohol Drinking; Female; Humans; India; Isoniazid; Kinetics; Male; Middl

1984
Aging and hepatotoxicity of isoniazid and rifampin in pulmonary tuberculosis.
    American journal of respiratory and critical care medicine, 1995, Volume: 152, Issue:5 Pt 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alanine Transaminase; Aspartate Aminotransferases

1995
Effects of chelators on iron uptake and release by the brain in the rat.
    Neurochemical research, 1994, Volume: 19, Issue:1

    Topics: 2,2'-Dipyridyl; Aging; Animals; Biological Transport; Bone and Bones; Brain; Deferiprone; Deferoxami

1994
The influence of aging on dimethylnitrosamine-demethylase enzyme kinetics in rat liver microsomes.
    Mechanisms of ageing and development, 1995, Aug-08, Volume: 82, Issue:2-3

    Topics: Aging; Animals; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Glutathione Transferase; Is

1995
In vitro protein binding characteristics of isoniazid, rifampicin, and pyrazinamide to whole plasma, albumin, and alpha-1-acid glycoprotein.
    Clinical biochemistry, 1996, Volume: 29, Issue:2

    Topics: Aging; Blood Proteins; Humans; In Vitro Techniques; Isoniazid; Orosomucoid; Plasma; Protein Binding;

1996
Isoniazid acetylation metabolic ratio during maturation in children.
    Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:4

    Topics: Acetylation; Adolescent; Aging; Antitubercular Agents; Arylamine N-Acetyltransferase; Child; Child,

1997
Increased abundance of GABAA receptor subunit mRNAs in the brain of Long-Evans Cinnamon rats, an animal model of Wilson's disease.
    Brain research. Molecular brain research, 1999, Jan-08, Volume: 63, Issue:2

    Topics: Aging; Analysis of Variance; Animals; Disease Models, Animal; Hepatolenticular Degeneration; Isoniaz

1999
[Behavioral disorders after treatment with isoniazid].
    Bulletin de la Societe de pathologie exotique (1990), 2001, Volume: 94, Issue:2

    Topics: Aging; Alcoholism; Antitubercular Agents; Behavior; Contraindications; Diabetes Mellitus; Female; Hu

2001
Influence of convulsants on rat brain activities of alanine aminotransferase and aspartate aminotransferase.
    Neurochemical research, 2001, Volume: 26, Issue:12

    Topics: 3-Mercaptopropionic Acid; Aging; Alanine Transaminase; Animals; Aspartate Aminotransferases; Brain;

2001
Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis.
    Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:4

    Topics: Acetylation; Aged; Aging; Antitubercular Agents; Arylamine N-Acetyltransferase; Chemical and Drug In

2002
Hepatic drug acetylation and oxidation: effects of aging in man.
    British medical journal, 1977, Jul-16, Volume: 2, Issue:6080

    Topics: Acetanilides; Acetylation; Adolescent; Adult; Aged; Aging; Half-Life; Humans; Isoniazid; Liver; Oxid

1977
A specific rapid gaschromatographic assay for the determination of isoniazid N-acetylation: observation in rats with induced constant urine flow.
    Biochemical medicine, 1975, Volume: 14, Issue:3

    Topics: Aging; Animals; Chromatography, Gas; Diuresis; Isoniazid; Rats

1975
Ontogenetic development of isonicotinehydrazide-induced seizures in rats.
    Brain & development, 1991, Volume: 13, Issue:2

    Topics: Aging; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Isoniazid; Male; Motor Activ

1991
The disposition of antituberculous drugs in plasma of elderly patients. I. Isoniazid and hydrazine metabolite.
    Methods and findings in experimental and clinical pharmacology, 1991, Volume: 13, Issue:8

    Topics: Acetylation; Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Isoniazid; Male; Middle Aged; Py

1991
The disposition of antituberculous drugs in plasma of elderly patients. II. Isoniazid, rifampicin and pyrazinamide.
    Methods and findings in experimental and clinical pharmacology, 1991, Volume: 13, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Isoniazid; Male; Metabolic Clearance Rate; Mi

1991
Aging and immunity to tuberculosis: prolonged survival of old mice infected with Mycobacterium tuberculosis by adoptive immunization with memory-immune T lymphocytes.
    Cellular immunology, 1989, Volume: 118, Issue:1

    Topics: Aging; Animals; Female; Immunization, Passive; Immunologic Memory; Isoniazid; Mice; Mice, Inbred C57

1989
Pharmacokinetics of isoniazid: influence of age.
    European journal of clinical pharmacology, 1986, Volume: 30, Issue:3

    Topics: Acetylation; Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Female; Half-Life; Humans; Inf

1986
Ageing and acetylator phenotype.
    European journal of clinical pharmacology, 1985, Volume: 29, Issue:3

    Topics: Acetylation; Aged; Aging; Female; Humans; Isoniazid; Male; Middle Aged; Pharmaceutical Preparations;

1985
Special problems in respiratory diseases.
    Geriatrics, 1974, Volume: 29, Issue:6

    Topics: Adrenal Cortex Hormones; Aged; Aging; Anti-Bacterial Agents; Anticoagulants; Asthma; Bronchodilator

1974
Synthesis of aldehydes and their interactions during the in vitro aging of collagen.
    Biochemistry, 1971, Jun-08, Volume: 10, Issue:12

    Topics: Acetates; Adipates; Aging; Aldehydes; Amines; Amino Acid Oxidoreductases; Aminopropionitrile; Animal

1971
Some aspects of pulmonary tuberculosis in older patients.
    Journal of the American Geriatrics Society, 1972, Volume: 20, Issue:5

    Topics: Aged; Aging; Aminosalicylic Acids; Drug Combinations; Female; Humans; Isoniazid; Male; Radiography;

1972
Effect of age, vitamin B6 deficiency, isoniazid and deoxypyridoxine on the urinary taurine of the rat.
    The Journal of nutrition, 1966, Volume: 90, Issue:1

    Topics: Aging; Animals; Isoniazid; Pyridoxine; Rats; Taurine; Vitamin B 6 Deficiency

1966
Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways.
    GeroScience, 2020, Volume: 42, Issue:4

    Topics: Aging; Animals; Hydra; Male; Reproduction; Reproduction, Asexual; Stem Cells

2020
The Piwi-piRNA pathway: road to immortality.
    Aging cell, 2017, Volume: 16, Issue:5

    Topics: Aging; Animals; CRISPR-Cas Systems; DNA Transposable Elements; Drosophila melanogaster; Gene Express

2017
FOXO3 and Exceptional Longevity: Insights From Hydra to Humans.
    Current topics in developmental biology, 2018, Volume: 127

    Topics: Aging; Animals; Forkhead Box Protein O3; Genome-Wide Association Study; Humans; Hydra; Longevity; Po

2018
Non-senescent
    Aging, 2018, 05-10, Volume: 10, Issue:5

    Topics: Aging; Animals; Cellular Senescence; Hydra; Lamins; Longevity; Nuclear Lamina; Stem Cells

2018
Hydra as Model to Determine the Role of FOXO in Longevity.
    Methods in molecular biology (Clifton, N.J.), 2019, Volume: 1890

    Topics: Aging; Animals; Animals, Genetically Modified; Forkhead Transcription Factors; Gene Expression Profi

2019
Loss of Neurogenesis in Aging Hydra.
    Developmental neurobiology, 2019, Volume: 79, Issue:5

    Topics: Aging; Animals; Cold Temperature; Eating; Gene Expression; Hydra; Movement; Nerve Degeneration; Neur

2019
Declining asexual reproduction is suggestive of senescence in hydra: comment on Martinez, D., "Mortality patterns suggest lack of senescence in hydra." Exp Gerontol 33, 217-25.
    Experimental gerontology, 2010, Volume: 45, Issue:9

    Topics: Aging; Animals; Hydra; Reproduction

2010
Environmental challenges improve resource utilization for asexual reproduction and maintenance in hydra.
    Experimental gerontology, 2011, Volume: 46, Issue:10

    Topics: Aging; Animals; Aphids; Biological Evolution; Genetics, Population; Hydra; Longevity; Models, Geneti

2011
Mortality patterns suggest lack of senescence in hydra.
    Experimental gerontology, 1998, Volume: 33, Issue:3

    Topics: Aging; Animals; Hydra; Mortality; Reproduction

1998
An integrated theory of ageing in the nematode Caenorhabditis elegans.
    Journal of anatomy, 2000, Volume: 197 Pt 4

    Topics: Aging; Animals; Biological Clocks; Biological Evolution; Caenorhabditis elegans; DNA Damage; Gene Ex

2000