Compounds > isoniazid
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isoniazid and Abnormalities, Autosome

isoniazid has been researched along with Abnormalities, Autosome in 35 studies

Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).

Research Excerpts

ExcerptRelevanceReference
"New effective compounds to treat tuberculosis are urgently needed."1.56Nonclinical evaluation of IQG-607, an anti-tuberculosis candidate with potential use in combination drug therapy. ( Abbadi, BL; Basso, LA; Bizarro, CV; Bondan da Silva, J; Machado, P; Picada, JN; Pissinate, K; Rodrigues-Junior, VS; Sperotto, NDM; Villela, AD, 2020)
") dosage extrapolated from dose that is used in human for 28 d once daily."1.46Deleterious effects of 28-day oral co-administration of first-line anti-TB drugs on spleen, blood and bone marrow chromosomes in normal rat. ( Sharma, R; Sharma, VL, 2017)
"The frequency of chromosomal aberrations and sister-chromatid exchanges (SCEs) did not show any statistically significant differences in the patients before treatment and after exposure to combined HRZ therapy as compared to controls (p > 0."1.29Cytogenetic study of tuberculosis patients before and after tuberculostatic drug treatment. ( Ekmekçi, A; Sayli, A, 1995)
"The frequency of chromosome aberrations was significantly increased in patients treated with both the triple drug combinations, i."1.27Cytogenetic effects of chemotherapy with three combinations of anti-tubercular drugs involving isoniazid, thiacetazone, para-aminosalicylic acid and streptomycin on human lymphocytes: chromosome aberrations, sister chromatid exchanges and mitotic index. ( Ahuja, YR; Jaju, M, 1983)
"These results suggest that chromosome aberrations and sister chromatid exchanges represent two different lesions."1.27Combined and individual effects of isoniazid and thiacetazone on human lymphocyte chromosomes in vitro and in vivo. ( Ahuja, YR; Jaju, M, 1984)
"The induction of chromosome aberrations was homogeneous and increased significantly in all the drug-exposed patients, whereas the frequency of sister chromatid exchanges (SCEs) was increased only in one of them."1.27Further study on the cytogenetic effects of combined chemotherapy with isoniazid and para-aminosalicylic acid on human lymphocytes in vivo: sister chromatid exchanges, chromosome aberrations in first-division metaphases, cell growth kinetics, and mitotic ( Ahuja, YR; Jaju, M, 1983)
" For both compounds, very similar dose-response curves were found for induction of chromatid breaks in the dose range 10-75 mg/kg."1.27Transplacental genetic and cytogenetic effects of alkylating agents in the mouse. II. Induction of chromosomal aberrations. ( Braun, R; Hüttner, E; Schöneich, J, 1986)
"No enhancement of chromosome aberrations could be observed after acute treatment of early primary spermatocytes or chronic treatment of spermatogonia with INH."1.26Cytogenetic study in spermatocytes of mice and Chinese hamsters after treatment with isoniazid (INH). ( Adler, ID; Müller, D; Perret, R; Rathenberg, R; Schmaltz, A; Strasser, FF, 1978)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199030 (85.71)18.7374
1990's2 (5.71)18.2507
2000's1 (2.86)29.6817
2010's1 (2.86)24.3611
2020's1 (2.86)2.80

Authors

AuthorsStudies
Rodrigues-Junior, VS1
Villela, AD1
Abbadi, BL1
Sperotto, NDM1
Pissinate, K1
Picada, JN1
Bondan da Silva, J1
Bizarro, CV1
Machado, P1
Basso, LA1
Sharma, R1
Sharma, VL1
Whiting, RF1
Wei, L1
Stich, HF1
Jaju, M10
Ahuja, YR5
Roman, IC2
Vainer, E1
Socosan, I1
Drăghicescu, T1
Ekmekçi, A1
Sayli, A1
Masjedi, MR1
Heidary, A1
Mohammadi, F1
Velayati, AA1
Dokouhaki, P1
Schroeder, TM1
Stahl-Maugé, C1
Müller, D4
Strasser, FF2
Röhrborn, G4
Fränz, J2
Grafe, A2
Mittenburger, HG1
Träger, H2
Pawlowitzki, IH3
Nautsch, C3
Okimoto, S1
Frohberg, H1
Schencking, MS1
Basler, A1
Bauchinger, M1
Gebhart, E2
Fonatsch, C1
Schmid, E1
Müller, W1
Obe, G2
Beek, B1
Göbel, D1
Radenbach, KL1
Miltenburger, HG4
Adler, ID3
Schmaltz, A3
Rathenberg, R2
Schwegler, H1
Perret, R1
Sezer, V1
Léonard, A1
Korte, A2
Schulze-Schenking, M1
Vogel, F2
Rac, VV1
Gupta, EV1
Thomas, IM1
Goulding, R1
Braun, R1
Hüttner, E1
Schöneich, J1
Kysela, D1
Matthee, H1
Nikol, M1
Kucerová, M1
Polívková, Z1
Sejdová, E1
Kliment, V1
Cirnu-Georgian, L2
Lenghel, V1
Kehler, E1
Hansmann, I1
Caratzali, A1
Geormaneanu, C1
Lüers, H1

Reviews

1 review available for isoniazid and Abnormalities, Autosome

ArticleYear
[Mutagenicity testing of chemical compounds].
    Arzneimittel-Forschung, 1974, Volume: 24, Issue:10

    Topics: Abortion, Spontaneous; Animals; Bone Marrow; Chromosome Aberrations; Cyclophosphamide; Drug Evaluati

1974

Other Studies

34 other studies available for isoniazid and Abnormalities, Autosome

ArticleYear
Nonclinical evaluation of IQG-607, an anti-tuberculosis candidate with potential use in combination drug therapy.
    Regulatory toxicology and pharmacology : RTP, 2020, Volume: 111

    Topics: Animals; Anti-Bacterial Agents; Chromosome Aberrations; Cytochrome P-450 Enzyme System; Disease Mode

2020
Deleterious effects of 28-day oral co-administration of first-line anti-TB drugs on spleen, blood and bone marrow chromosomes in normal rat.
    Drug and chemical toxicology, 2017, Volume: 40, Issue:2

    Topics: Administration, Oral; Animals; Antitubercular Agents; Biomarkers; Bone Marrow Cells; Chromosome Aber

2017
Enhancement by transition metals of chromosome aberrations induced by isoniazid.
    Biochemical pharmacology, 1980, Mar-01, Volume: 29, Issue:5

    Topics: Animals; Antitubercular Agents; CHO Cells; Chromosome Aberrations; Cricetinae; Cricetulus; Dose-Resp

1980
Cytogenetic effects of chemotherapy with three combinations of anti-tubercular drugs involving isoniazid, thiacetazone, para-aminosalicylic acid and streptomycin on human lymphocytes: chromosome aberrations, sister chromatid exchanges and mitotic index.
    Human genetics, 1983, Volume: 64, Issue:1

    Topics: Aminosalicylic Acid; Antitubercular Agents; Chromosome Aberrations; Crossing Over, Genetic; Drug Eva

1983
Genetic effects of drug interaction in tuberculosis patients and their fate.
    Teratogenesis, carcinogenesis, and mutagenesis, 1984, Volume: 4, Issue:3

    Topics: Aminosalicylic Acid; Antitubercular Agents; Cells, Cultured; Chromosome Aberrations; Crossing Over,

1984
Combined and individual effects of isoniazid and thiacetazone on human lymphocyte chromosomes in vitro and in vivo.
    Human toxicology, 1984, Volume: 3, Issue:5

    Topics: Cell Division; Chromosome Aberrations; Chromosomes; Humans; In Vitro Techniques; Isoniazid; Kinetics

1984
Further study on the cytogenetic effects of combined chemotherapy with isoniazid and para-aminosalicylic acid on human lymphocytes in vivo: sister chromatid exchanges, chromosome aberrations in first-division metaphases, cell growth kinetics, and mitotic
    Environmental mutagenesis, 1983, Volume: 5, Issue:6

    Topics: Adolescent; Adult; Aminosalicylic Acid; Aminosalicylic Acids; Chromosome Aberrations; Crossing Over,

1983
Incidence of chromosomal aberrations in patients under combined tuberculostatic chemotherapy.
    Human genetics, 1983, Volume: 63, Issue:2

    Topics: Antitubercular Agents; Chromosome Aberrations; Drug Therapy, Combination; Ethambutol; Humans; Isonia

1983
Combined action of isoniazid and para-aminosalicylic acid in vivo on human chromosomes in lymphocyte cultures.
    Human genetics, 1981, Volume: 56, Issue:3

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Cells, Cultured; Chromosome Aberrations; Chromosomes; Dru

1981
Cytogenetic study of tuberculosis patients before and after tuberculostatic drug treatment.
    Mutation research, 1995, Volume: 334, Issue:2

    Topics: Adult; Antitubercular Agents; Cell Division; Chromosome Aberrations; Drug Combinations; Female; Huma

1995
Chromosomal aberrations and micronuclei in lymphocytes of patients before and after exposure to anti-tuberculosis drugs.
    Mutagenesis, 2000, Volume: 15, Issue:6

    Topics: Adolescent; Adult; Age Factors; Aged; Antibiotics, Antitubercular; Antitubercular Agents; Case-Contr

2000
Mutagenic effects of isonicotinic acid hydracide in Fanconi's anemia.
    Human genetics, 1979, Volume: 52, Issue:3

    Topics: Adolescent; Adult; Anemia, Aplastic; Cells, Cultured; Child; Chromosome Aberrations; Chromosomes, Hu

1979
Chromosome analysis of bone marrow in mammals after treatment with isoniazid.
    Human genetics, 1978, May-16, Volume: 42, Issue:1

    Topics: Animals; Bone Marrow; Chromosome Aberrations; Chromosomes; Cricetinae; Female; Isoniazid; Karyotypin

1978
Analysis of chromosome aberrations in bone marrow cells of rats after treatment with isoniazid.
    Human genetics, 1978, May-16, Volume: 42, Issue:1

    Topics: Animals; Bone Marrow; Chromosome Aberrations; Injections, Intraperitoneal; Injections, Intravenous;

1978
Mutagenicity of isoniazid: testing for somatic chromosome aberrations in mouse embryos.
    Human genetics, 1978, May-16, Volume: 42, Issue:1

    Topics: Animals; Chromosome Aberrations; Female; Isoniazid; Maternal-Fetal Exchange; Mice; Pregnancy; Time F

1978
Chromosome analyses in man in the course of chemoprophylaxis against tuberculosis and of antituberculosis chemotherapy with isoniazid.
    Human genetics, 1978, May-16, Volume: 42, Issue:1

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chromosome Aberrations; Chromosomes; Female; Human

1978
The effect of isoniazid (INH) on Chinese hamster and mouse spermatogonia.
    Human genetics, 1978, May-16, Volume: 42, Issue:1

    Topics: Animals; Chromosome Aberrations; Cricetinae; Isoniazid; Male; Mice; Spermatogonia; Spermatozoa; Time

1978
Cytogenetic study in spermatocytes of mice and Chinese hamsters after treatment with isoniazid (INH).
    Human genetics, 1978, May-16, Volume: 42, Issue:1

    Topics: Animals; Chromosome Aberrations; Chromosomes; Cricetinae; Isoniazid; Male; Meiosis; Metaphase; Mice;

1978
Effects of isoniazid (INH) on the oogenesis of mice.
    Human genetics, 1978, May-16, Volume: 42, Issue:1

    Topics: Animals; Chromosome Aberrations; Female; Isoniazid; Mice; Oocytes; Oogenesis; Time Factors

1978
Heritable chromosome aberrations in mammals after exposure to chemicals.
    Radiation and environmental biophysics, 1976, Mar-30, Volume: 13, Issue:1

    Topics: Aflatoxins; Alkylating Agents; Aminoquinolines; Animals; Antimalarials; beta-Aminoethyl Isothiourea;

1976
[On the simultaneous effects of ionising radiation and chemical agents on animal cells. 1st communication. Cytogenetic studies on X-rays and isonicotinic acid hydrazide in the Chinese hamster, Cricetulus griseus (author's transl)].
    Arzneimittel-Forschung, 1976, Volume: 26, Issue:7

    Topics: Animals; Chromosome Aberrations; Chromosomes; Cricetinae; Dose-Response Relationship, Drug; Dose-Res

1976
Proceedings: Chromosome analysis of bone marrow and nucleus anomaly test in mammals after treatment with INH.
    Mutation research, 1975, Volume: 29, Issue:2

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Nucleus; Chromosome Aberrations; Cricetinae; Isoniazid

1975
Proceedings: Chromosome analysis in spermatogonia of mammals.
    Mutation research, 1975, Volume: 29, Issue:2

    Topics: Animals; Chromosome Aberrations; Chromosomes; Cricetinae; Isoniazid; Male; Mammals; Mice; Mutagens;

1975
Approaches to an evaluation of the genetic load due to mutagenic agents in the human population.
    Mutation research, 1975, Volume: 29, Issue:2

    Topics: Age Factors; Antibiotics, Antineoplastic; Chromosome Aberrations; Chromosome Disorders; Environmenta

1975
Chromosomal aberrations in tuberculosis patients before and after treatment with short-term chemotherapy.
    Mutation research, 1991, Volume: 259, Issue:1

    Topics: Chromosome Aberrations; Drug Therapy, Combination; Humans; Isoniazid; Mutagens; Pyrazinamide; Rifamp

1991
Combined and individual effects of isoniazid and thiacetazone on human lymphocyte chromosomes in vitro and in vivo.
    Human toxicology, 1985, Volume: 4, Issue:2

    Topics: Chromosome Aberrations; Humans; In Vitro Techniques; Isoniazid; Lymphocytes; Thioacetazone

1985
Transplacental genetic and cytogenetic effects of alkylating agents in the mouse. II. Induction of chromosomal aberrations.
    Teratogenesis, carcinogenesis, and mutagenesis, 1986, Volume: 6, Issue:1

    Topics: Alkylating Agents; Animals; Chromosome Aberrations; Cyclophosphamide; Dose-Response Relationship, Dr

1986
Cytogenetic analyses utilizing various clastogens in two sibs with Fanconi anemia, their relatives, and control individuals.
    Human genetics, 1985, Volume: 69, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Adult; Anemia, Aplastic; Bromodeoxyuridine; Cells, Cultured; Child; Child,

1985
[The effect of tuberculostatic agents on chromosomes in children].
    Ceskoslovenska pediatrie, 1985, Volume: 40, Issue:9

    Topics: Adult; Antitubercular Agents; Child; Child, Preschool; Chromosome Aberrations; Humans; Isoniazid; Ma

1985
Isoniazid-induced chromosome aberrations.
    Lancet (London, England), 1971, Jul-10, Volume: 2, Issue:7715

    Topics: Animals; Chromosome Aberrations; Female; Injections, Intravenous; Isoniazid; Rats

1971
[Isoniazid mutagenesis in mammals and man].
    Praxis der Pneumologie, 1974, Volume: 28 Suppl

    Topics: Animals; Chromosome Aberrations; Cricetinae; Female; Humans; Isoniazid; Male; Mammals; Mice; Mutagen

1974
[Identification of human chromosomes by chromomerization in vitro].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1972, Feb-21, Volume: 274, Issue:8

    Topics: Aminosalicylic Acids; Antitubercular Agents; Cells, Cultured; Chromosome Aberrations; Chromosomes; C

1972
Inter- and intrachromosomal distribution of achromatic lesions and chromatid breaks in human chromosomes.
    Mutation research, 1972, Volume: 16, Issue:3

    Topics: Chromatids; Chromosome Aberrations; Chromosomes, Human, 1-3; Chromosomes, Human, 13-15; Chromosomes,

1972
The clinical importance of pharmacogenetics.
    California medicine, 1969, Volume: 111, Issue:4

    Topics: Adult; Aged; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Congenital Abnormalitie

1969