isomethyleugenol has been researched along with Neoplasms in 678 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 80 (11.80) | 18.7374 |
1990's | 58 (8.55) | 18.2507 |
2000's | 95 (14.01) | 29.6817 |
2010's | 265 (39.09) | 24.3611 |
2020's | 180 (26.55) | 2.80 |
Authors | Studies |
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Chen, Q; Yang, B | 1 |
Cheng, M; Ding, C; Flavell, RA; Li, HB; Peng, H; Song, H; Song, J; Sun, R; Tian, S; Tian, Z; Wang, T; Wei, H; Zheng, M; Zhu, S | 1 |
Chen, J; Cook, N; Wu, D; Zhou, J | 1 |
Richard, S; Xu, J | 1 |
Chen, ZS; Tan, Y; Wang, JQ; Yang, B; Yuan, R; Zou, C | 1 |
Kumar, VC; Pai, R | 1 |
Ahmad, T; Bacolla, A; Brickner, JR; Casanova, AG; Ganguly, A; He, C; Lukinović, V; Mosammaparast, N; Oyeniran, C; Reynoird, N; Rodell, R; Soll, JM; Sun, H; Tainer, JA; Townley, BA; Tsao, N; Vindigni, A; Wood, M; Zhang, L | 1 |
Barros-Silva, D; Jenster, G; Jerónimo, C; Klavert, J; Lafontaine, DLJ; Martens-Uzunova, ES | 1 |
Hamada, K; Kono, H; Kumar, A; Machiyama, A; Nishizawa, T; Nureki, O; Ogata, K; Oguni, A; Okada, C; Sakuraba, S; Sato, K; Sengoku, T | 1 |
Ghergurovich, JM; Rabinowitz, JD; Ryseck, RP; Wang, JZ; Wang, L; Xu, X; Yang, L | 1 |
Bradford, STJ; Dressler, GR; Grimley, E; Laszczyk, AM; Lee, PH; Patel, SR | 1 |
Adamo, ME; Cressey, LE; Greiner, EC; Kettenbach, AN; Lyons, SP | 1 |
Zhang, W | 1 |
Chan, CSY; Cheng, YY; Lau, KS; Leung, WK; Ma, ZY; Ng, L | 1 |
Cheng, L; Gong, Y; Liu, L; Lu, S; Ma, F; Peng, Q; Wang, Y; Wei, C | 1 |
Gao, C; Li, H; Liu, C; Ma, X; Sun, C; Yu, H; Zhuang, J | 1 |
Guo, L; Huang, L; Shi, Y; Yang, H; Zhang, J; Zhou, C | 1 |
Alkan, HF; Altea-Manzano, P; Fendt, SM | 1 |
Chen, ES; Lam, UTF | 1 |
An, Y; Duan, H | 1 |
Chen, P; Chen, Y; Han, X; Hu, J | 1 |
Aránega, A; Dueñas, Á; Franco, D; García-López, V; Garcia-Martínez, V; García-Padilla, C; López-Sánchez, C | 1 |
Hu, D; Li, H; Liu, J; Liu, L; Shao, W; Wang, Y; Yang, S; Zhang, J; Zhong, J | 1 |
Gong, Z; Liu, Y; Shi, L; Wang, Y; Xiong, W; Yan, Q; Zeng, Z; Zhang, M; Zhang, S; Zhi, K; Zhi, Y; Zi, M | 1 |
Chen, Y; Guan, Q; Guo, H; He, J; Lin, H; Miao, L; Zhuo, Z | 1 |
An, S; Kang, JS; Lee, J; Lee, SJ | 1 |
Abbasi, Y; Anbiyaee, O; Farzaneh, M; Ghaedrahmati, F; Gholami, E; Kuchaki, Z; Meybodi, SM; Rashid Sheykhahmad, F | 1 |
Chen, CJ; Chiou, HY; Hsu, KH; Lee, CH; Liao, PJ | 1 |
Atadja, P; Blanz, J; Chen, Z; Dillon, MP; Dubost, V; Fang, D; Feng, L; Fu, X; Gao, Z; Gu, J; Huang, Y; Jeay, S; Kiffe, M; Li, E; Li, L; Lingel, A; Luo, F; Luo, X; Mi, Y; Mistry, P; Moggs, J; Oyang, C; Pearson, D; Piaia, A; Pissot-Soldermann, C; Qi, W; Scheufler, C; Sendzik, M; Sun, Y; Terranova, R; Wang, L; Weiss, A; Yu, Z; Zeng, J; Zhang, H; Zhang, J; Zhang, L; Zhang, Q; Zhao, K; Zhao, M | 1 |
Guzman, MIT; Liow, P; Qi, J; Wang, MY | 1 |
Deng, L; Fan, Y; Gao, Z; Guo, X; Li, G; Wang, S; Xu, J; Xue, H; Zhang, P; Zhang, Z; Zhao, R | 1 |
Akhmetshina, A; Burgering, B; Eisenberg, T; Fasching, S; Hörl, G; Jany-Luig, E; Kerbl-Knapp, J; Korbelius, M; Kratky, D; Kuentzel, KB; Macher, T; Mack, M; Madl, T; Meinitzer, A; Paar, M; Pertschy, B; Pirchheim, A; Rinner, B; Rodriguez Colman, MJ; Stelzl, U; Steyrer, E; Vujić, N; Zhang, F | 1 |
Dai, W; Gong, J; Gong, Y; He, F; Li, S; Liu, Q; Tang, F; Wang, Z; Xie, C; Yang, Z; Zhang, J | 1 |
Chen, J; Chen, X; Lu, Z; Mo, S; Yu, S; Zong, L | 1 |
Guil, S; Ramesh-Kumar, D | 1 |
Clement, JH; Crodel, CC; Eifert, T; Ernst, P; Heidel, FH; Hochhaus, A; Hsu, CJ; Huber, N; Hübner, CA; Jayavelu, AK; Perner, F; Schnöder, TM; Tubío-Santamaría, N; Ungelenk, M | 1 |
Barghout, SH; Barsyte-Lovejoy, D; Machado, RAC | 1 |
Duan, M; Jiang, X; Liu, H; Qian, Y; Wang, G; Wang, Y; Yang, Z; Zhang, F; Zhang, Z | 1 |
Han, Y; Ju, HQ; Li, B; Li, H; Li, JJ; Liao, K; Lin, JF; Lu, YX; Luo, XJ; Meng, Q; Tan, YT; Wang, ZX; Wei, C; Xu, RH; Yu, K; Zeng, ZL | 1 |
Diao, W; Li, Y; Wang, J; Xu, S; Zheng, J | 1 |
Chen, YX; Ju, HQ; Li, T; Liao, K; Lin, J; Mo, HY; Piao, HL; Tan, YT; Wang, W; Xu, RH; Yang, W; Zheng, XJ | 1 |
Cavaretta, JP; Huang, L; Huang, T; Lee, MM; Moon, D; Rozen, EJ; Sallis, B; Shohet, JM; Sun, X; Verdejo-Torres, O; Wang, G; Wigglesworth, K; Wu, Q; Zhang, L; Zhang, XO | 1 |
Lin, H; Long, F; Wang, P; Wang, T; Wang, Y | 1 |
Joosse, SA; Pantel, K | 1 |
Acunzo, M; Del Valle-Morales, D; Le, P; Nana-Sinkam, P; Nigita, G; Romano, G; Saviana, M | 1 |
Rao, GW; Zhang, W; Zheng, Q | 1 |
Klein, EA | 1 |
Aggad, WS; Almohaimeed, HM; Alshanwani, AR; Assiri, R; Hengwei, Y; Raza, SHA; Wenzhen, Z; Xinran, Y; Zan, L | 1 |
Huang, H; Huang, T; Jiang, J; Li, Y; Wu, S; Zhou, Y | 1 |
Abou-Aisha, K; Elsabbagh, RA; Gad, MZ; Rady, M; Watzl, C | 1 |
Fan, Y; Gao, Z; Li, X; Sun, H; Yuan, K; Zhu, Z | 1 |
Bai, Y; Cui, G; Han, T; Li, Q; Li, X; Li, Y; Lu, D; Qu, D; Sun, H; Sun, X; Wang, S; Yang, Y; Zhang, Q; Zhao, L; Zhao, N | 1 |
Cao, Y; Huang, H; Jiang, X; Kuang, Y; Li, X; Ren, C; Shen, W; Wang, L; Yin, W; Zhou, Q; Zhou, Y; Zhu, H | 1 |
Aldesoky, AI; Alhanafy, AM; Duose, DY; Gouda, MA; Huang, HJ; Janku, F; Kopetz, S; Lapin, M; Luthra, R; Meric-Bernstam, F; Shehata, MA; Wang, J; Wistuba, II; Xi, Y; Zalles, S; Zheng, X | 1 |
Li, F; Xu, YL; Yang, FF | 1 |
Chhabra, R; Sarraf, G | 1 |
Ge, L; Li, J; Wang, H; Wang, Z; Zhang, H; Zhou, J | 1 |
Guo, T; Li, Y; Liu, R; Liu, Y; Yi, J; Zhou, Y | 1 |
Hsu, SH; Hung, WC | 1 |
Azmani, R; Baud, J; Bochaton, D; Bourdeaut, F; Cardoen, L; Chrétien, F; Croce, S; Duchesne, M; Guillemot, D; Hasty, L; Hostein, I; Kesrouani, C; Le Loarer, F; Le Quang, M; Lechapt, E; Métais, A; Pierron, G; Puget, S; Tauziède-Espariat, A; Varlet, P | 1 |
Hong, J; Lee, JH; Xu, K | 1 |
Chu, BC; Chung, G; Clement, J; Hubbell, E; Kurtzman, KN; Roberts, LR; Shao, S; Swanton, C; Tang, WHW; Tummala, M; Yimer, H | 1 |
Fogle, HM; Krupenko, NI; Krupenko, SA; McCormac, JP; Molina, S; Rushing, BR; Sharma, J; Sumner, S; You, M | 1 |
Bi, Z; Cao, J; Feng, Q; Li, L; Yu, L; Zhang, Q; Zhang, Y | 1 |
Abedeera, SM; Abeysirigunawardena, SC; Rauff, R; Schmocker, S; Xie, J | 1 |
Falone, S; Ponzetti, M; Rucci, N | 1 |
Guccione, E; Kaldis, P; Zhao, LN | 1 |
Jeoung, D; Jo, H; Shim, K | 1 |
Freedy, AM; Kissler, SM; Kwok, HS; Liau, BB; Morriss, JW; Siegenfeld, AP; Waterbury, AL | 1 |
Bettegowda, C; Cohen, JD; Curtis, S; Dobbyn, L; Douville, C; Dudley, JC; Ho-Pham, LT; Kinzler, KW; Mattox, A; Nehme, N; Nguyen, TV; Papadopoulos, N; Popoli, M; Ptak, J; Silliman, N; Summers, M; Tran, BNH; Tran, TS; Vogelstein, B; Wang, Y; Zhang, M | 1 |
Du, D; He, F; He, J; Ju, C; Li, H; Wang, C; Zhou, M | 1 |
Benetti, S; Biancalana, L; Dalla Pozza, M; Gasser, G; Marchetti, F; Zacchini, S | 1 |
Fan, C; Guo, C; Hou, X; Jiang, W; Li, G; Li, L; Li, Z; Liao, Q; Ouyang, J; Tang, Q; Wang, F; Wang, H; Wang, Y; Wu, P; Xiang, B; Xiong, W; Zeng, Z; Zhou, M | 1 |
He, C; Pomaville, MM | 1 |
Liu, Y; Yang, Q | 1 |
Bashtrykov, P; Bröhm, A; Bui, T; Jeltsch, A; Khella, MS; Pleiss, J; Schnee, P; Weirich, S | 1 |
Chen, G; Chen, L; Chen, X; He, Y; Liu, S; Ni, Z; Qi, S; Xie, T; Zhang, H; Zhao, S; Zhou, Y; Zhu, J | 1 |
Liang, Y; Peng, N; Wang, H; Wu, B; Wu, X; Yu, D; Zhong, X | 1 |
Jiao, Y; Tao, D; Wang, J; Wang, L; Xu, X; Xu, Y; Yu, B; Zhuang, H | 1 |
Huang, X; Lin, D; Zeng, L; Zhang, J; Zheng, J | 1 |
Meng, XY | 1 |
Buchanan, DD; Dugué, PA; English, DR; Giles, GG; Hodge, AM; Hopper, JL; Joo, JE; Jung, CH; Makalic, E; Milne, RL; Schmidt, D; Severi, G; Southey, MC; Wong, EM; Yu, C | 1 |
Bai, C; Chen, S; Gao, S; Guan, H; Han, Y; Huang, R; Huang, X; Jia, J; Li, H; Li, Y; Long, D; Luo, J; Sun, X; Xie, D; Ye, Y; Zhou, PK | 1 |
Aldana, J; Freitas, MA; Gardner, ML | 1 |
Hong, LL; Li, P; Ling, ZQ; Liu, Z; Qi, YN | 1 |
Abbott, KL; Bosenberg, M; Burns, MJ; Chen, D; Esparza Moltó, PB; Farsakoglu, Y; Hargreaves, DC; Hoffmann, FA; Johnson, MA; Kaech, SM; Kunchok, T; Mangalhara, KC; Mendiratta, G; Parisi, B; Rincon, M; Rojas, GR; Sainz, AG; Shadel, GS; Tadepalle, N; Vander Heiden, MG; Varanasi, SK | 1 |
Afenjar, A; Banka, S; Barish, S; Bellen, HJ; Blyth, M; Choufani, S; Costain, G; Cytrynbaum, C; Deshwar, AR; Haldeman-Englert, C; Hayes, I; Haynes, D; Huang, Y; Jobling, R; Kanca, O; Keren, B; Le Quesne Stabej, P; Mao, X; Mignot, C; Nil, Z; Prescott, T; Robin-Renaldo, F; Shinawi, M; Sisco, K; Tveten, K; Vøllo, A; Wangler, MF; Wegner, DJ; Weksberg, R; Wheeler, PG; Wilson, C; Yamamoto, S; Yap, P; Zhang, X; Zon, J | 1 |
Huo, FC; Pei, DS; Shan, HJ; Zhang, J; Zhu, ZM | 1 |
Chai, X; Fang, Z; He, L; Huang, T; Jiang, B; Liu, C; Liu, M; Sun, P; Zeng, D; Zhan, J; Zhang, X; Zhou, X; Zhu, Q | 1 |
Perez, MF; Sarkies, P | 1 |
Karimian, A; Kurdistani, SK; Vogelauer, M | 1 |
Chen, C; Duan, X; Guo, X; Li, L; Sun, S; Wang, L; Wang, W; Wei, Y; Xue, W; Yang, Y; Yao, W; Zhao, J | 1 |
Han, M; Hu, J; Liu, J; Sun, H; Sun, Z; Yuan, W; Zhou, Q | 1 |
Fan, XN; Huang, Y; Meng, J; Zhang, SW; Zhang, SY; Zhang, T | 1 |
Jaffrey, SR; Ries, RJ; Zaccara, S | 1 |
Bai, J; Chen, X; Li, X; Li, Y; Qu, Y; Tian, Y; Wang, Q; Xiao, J; Xu, J; Zhang, Y | 1 |
Cornett, EM; Defossez, PA; Ferry, L; Rothbart, SB | 1 |
Ban, HS; Cho, HS; Han, TS; Hur, K | 1 |
Hirata, Y | 1 |
Birsoy, K; Weber, R | 1 |
Chen, C; Ji, X; Kan, Q; Liu, J; Ma, S; Sun, Z; Wang, G; Yuan, W; Zhou, Q | 1 |
Asai, A; Ishii, H; Konno, M; Koseki, J; Taniguchi, M; Vecchione, A | 1 |
He, L; Li, H; Peng, Y; Shu, G; Wu, A; Yin, G | 1 |
Casanova, AG; Chuffart, F; Lukinović, V; Reynoird, N; Roth, GS | 1 |
Gong, C; Hu, Y; Huang, Y; Liu, J; Wang, S; Xiao, Y; Yang, S | 1 |
Bai, Y; Fu, X; Jiang, H; Liu, R; Liu, X; Ma, S | 1 |
Li, J; Wang, F; Xie, L; Xie, Y | 1 |
Margueron, R; Richart, L | 1 |
Fujimori, DG; Longbotham, JE; Petronikolou, N | 1 |
Muthusamy, S | 1 |
Cai, Y; Jin, J; Wei, T; Zhu, H | 1 |
Jagtap, SV; Rasal, NK; Sonawane, RB | 1 |
Chen, J; Huang, K; Li, J; Li, R; Sun, R; Wang, Y; Xie, K; Yang, Q; Zhang, T; Zhang, Y; Zhao, Q; Zou, L | 1 |
Liu, JY; Wellen, KE | 1 |
Arnott, D; Cheung, TK; Classon, M; Guler, GD; Lill, J; Masselot, A; Pham, V; Pitti, R; Stephan, JP; Tindell, CA; Wilson, C | 1 |
Chen, F; Hao, W; Jiang, M; Lin, J; Liu, B; Sun, D; Tang, C; Xing, H; Yang, J; Yu, M; Zhang, X; Zhao, Y; Zhu, Y | 1 |
Bailleux, C; Barranger, E; Delaloge, S; Lacroix, L | 1 |
Hussain, S | 1 |
Al-Hamashi, AA; Diaz, K; Huang, R | 1 |
Choe, J; Han, SH | 1 |
Burbage, M; Gros, M | 1 |
Asano, T | 1 |
Bao, X; Bindra, RS; Dow, J; Economos, NG; Glazer, PM; King, MC; Li, J; Liu, Y; Mirfakhraie, L; Noronha, K; Oeck, S; Shuch, BM; Sulkowski, PL | 1 |
Chen, H; Duan, M; Lan, L; Levine, AS; Ouyang, J; Tan, J; Truesdell, SS; Vasudevan, S; Wang, Y; Wei, L; Yadav, T; Yang, H; Zhu, X; Zou, L | 1 |
Cheng, L; Li, L; Liang, Y; Liu, M; Wang, R; Xia, J; Yue, L; Zhang, L; Zhang, N | 1 |
Deng, D; Liu, W; Tian, W; Xiang, M; You, A | 1 |
Bao, Y; Du, R; Gao, W; Li, J; Luo, N; Shen, W; Wang, J; Yang, W; Zhang, X | 1 |
He, Q; Qian, M; Yan, F; Yang, B; Yuan, T; Zhu, H | 1 |
Klein, EA; Liu, MC; Oxnard, GR; Seiden, M; Swanton, C | 1 |
Hao, L; Ji, LN; Mao, ZW; Pan, ZY; Rao, LS; Tan, CP; Zhang, H; Zheng, Y | 1 |
Du, W; Duan, R; Guo, W | 1 |
Chen, XY; Yi, YC; Zhang, J; Zhu, JS | 1 |
Kanbur, E; Stanley, BA; Tümer, E; Yerlikaya, A | 1 |
Gubser, PM; Kallies, A | 1 |
Huang, W; Li, Y; Weng, H; Zeng, C | 1 |
Du, R; Luo, N; Shen, W; Xiang, R; Zhang, X | 1 |
Bian, Y; Chinnaiyan, AM; Cieslik, M; Crespo, J; Czerwonka, A; Grove, S; Kremer, DM; Kryczek, I; Li, J; Li, S; Li, W; Liao, P; Liu, JR; Lyssiotis, CA; McLean, K; Nwosu, ZC; Okła, K; Pawłowska, A; Sajjakulnukit, P; Szeliga, W; Vatan, L; Wallner, G; Wei, S; Wertel, I; Xia, H; Yu, J; Zgodziński, W; Zhang, L; Zou, W | 1 |
Assaraf, YG; Chen, ZS; Huang, C; Jiang, J; Li, B; Xiao, H | 1 |
Fan, W; Kong, Y; Li, N; Tao, T; Xiao, Q; Zhou, Y; Zhu, X | 1 |
Huang, G; Yu, Z; Zhang, G | 1 |
Chun, KS; Jang, JH; Kim, DH | 1 |
Amere Subbarao, S; Kotwal, A | 1 |
Huo, FC; Pei, DS; Zhu, ZM | 1 |
Klonou, A; Markouli, M; Papavassiliou, AG; Piperi, C; Strepkos, D | 1 |
Li, MO; Shyu, A; Xu, K | 1 |
Coller, HA; Corvalan, AZ | 1 |
Han, X; Wang, M; Yang, Y; Yang, YG; Zhao, YL | 1 |
Affar, EB; Barbour, H; Daou, S; Hendzel, M | 1 |
Chen, J; He, Z; Ren, D; Tian, Y; Wang, L; Yan, X; Yuan, X; Zhang, Q; Zhang, T; Zhang, W | 1 |
Faccin, L; Lapolla, A; Ragazzi, E; Sartore, G | 1 |
Ji, LN; Ling, Y; Mao, ZW; Tan, CP; Wang, H; Yang, GG; Zhang, DY; Zhang, H; Zheng, Y | 1 |
Kanakamani, S; Suresh, PS; Venkatesh, T | 1 |
Annan, RS; Creasy, CL; Liu, Y; McHugh, CF; Mohammad, HP; Montes de Oca, R; Noto, PB; Piccoli, SP; Sikorski, TW; Szapacs, ME; Wagner, CD; Zappacosta, F | 1 |
Barshop, W; Bradley, LM; Finlay, D; Garcia, G; Gimple, RC; Hope, JL; Qiu, Z; Rantala, J; Rich, JN; Sangfelt, O; Shen, JZ; Spruck, C; Sun, D; Wohlschlegel, J; Wu, Q | 1 |
Cao, Y; Cheng, Z; Deng, P; Gozani, O; Jia, Y; Li, W; Patel, DJ; Qin, Y; Ren, J; Sengupta, D; Tian, W; Wang, Z; Yuan, G; Zhou, Y | 1 |
Blyuss, O; Ceroni, F; Conole, D; Di Blasi, R; Timms, JF; Whitwell, HJ | 1 |
Goel, PN; Greene, MI; Grover, P | 1 |
Fan, M; Li, X; Liu, Z; Pan, S; Wang, H | 1 |
Dere, R; Young, NL | 1 |
Sroka, MW; Vakoc, CR | 1 |
Bai, J; Cai, Y; Chang, Z; Li, D; Li, Y; Xu, J; Xu, K; Zhang, M; Zou, H | 1 |
Chen, Y; Duan, L; Jiang, X; Jin, Z; Liu, B; Nie, Z; Xiong, Q; Yang, C | 1 |
Allis, CD; Chen, H; Chen, X; Lu, C; Majewski, J; Rajagopalan, KN; Weinberg, DN | 1 |
Ribatti, D | 1 |
Liu, F; Su, X | 1 |
Paramasivam, A; Priyadharsini, JV | 1 |
Jeon, M; Kim, H; Lee, JM; Park, IG | 1 |
Song, J; Sun, Z; Yuan, W; Zhang, M; Zhang, W | 1 |
Broehm, A; Choudalakis, M; Eisler, SA; Fuchs, M; Jeltsch, A; Knodel, F; Kroll, C; Pinter, S; Rathert, P; Roth, M; Schnee, P; Weirich, S; Zuber, J | 1 |
Liu, Q; Liu, T; Lu, X; Zheng, S | 1 |
Chen, F; Hu, Z; Jiang, Y; Li, Y; Lin, L; Liu, Z; Shen, H; Shen, S; Wei, Y; Zhang, R; Zhao, Y | 1 |
Dong, S; Huang, H; Liu, Y; Weng, H; Wu, Y | 1 |
Deshmukh, S; Jabado, N; Krug, B; Ptack, A | 1 |
Bae, GU; Cho, Y; Hwang, JW; Kim, SN; Kim, YK | 1 |
Di Tullio, F; Guccione, E; Mzoughi, S; Schwarz, M | 1 |
Jiang, C; Kan, Z; Li, YF; Liu, LY; Ma, WL; Mohammed, R; Nikolaev, A; Song, WW; Zhang, ZF | 1 |
Dabelić, N; Fröbe, A; Mojzeš, A; Novak Kujundžić, R; Prpić, M; Tomljanović, M; Trošelj, KG; Đaković, N | 1 |
Brownell, JE; Zhai, X | 1 |
Fan, Z; Guo, J; Han, X | 1 |
Battistelli, C; Garbo, S; Zwergel, C | 1 |
Cao, D; Hu, C; Li, C; Li, S; Lv, M; Pan, W; Yang, A; Yang, Z; Yi, X; Zhang, K; Zhang, L; Zhang, P; Zhu, L; Zhu, Y | 1 |
Bell, JL; Hüttelmaier, S; Lan, Q; Liu, PY; Liu, T; Wang, JY; Zhang, L; Zhang, XD | 1 |
Baek, HJ; Jeon, M; Kim, H; Park, J; Yang, E | 1 |
Cai, Z; Jia, G; Song, P; Tayier, S | 1 |
Gao, X; Han, B; Li, F; Li, Z; Wei, S; Zhang, J | 1 |
Ali, R; Aspris, D; Bernardes, GJL; Bradley, A; De Braekeleer, E; Fischer, ES; Garyfallos, DA; Gregory, RI; Gu, M; Gutierrez, A; Lim, J; Liu, Q; Mikutis, S; Orellana, EA; Pirouz, M; Sendinc, E; Slack, FJ; Tzelepis, K; Vassiliou, GS; Yankova, E; Zhang, W | 1 |
Ju, S; Ma, S; Tao, M; Xu, Y; Zhang, W; Zheng, M | 1 |
Kong, M; Lowman, XH; Tran, TQ | 1 |
Cebrián, ME; Franco-Marina, F; Gamboa-Loira, B; López-Carrillo, L | 1 |
Maddocks, ODK; Newman, AC | 1 |
Alag, N; Arnott, D; Chen, KB; Classon, M; Cuellar, T; Giresi, PG; Guler, GD; Haley, B; Hegde, G; Jackson, E; Jhunjhunwala, S; KaiWai Cheung, T; Kim, HJ; Liu, J; Nance, TL; Nichols, K; Pitti, R; Settleman, J; Stephan, JP; Tindell, CA; Webster, J; Wilson, C; Wongchenko, M; Yan, Y | 1 |
Alam, M; Bouillez, A; Christensen, CL; Hiraki, M; Kufe, D; Rajabi, H; Samur, M; Tagde, A; Wong, KK | 1 |
Li, H; Li, J; Ma, Z; Qiu, M; Sun, C; Wang, S; Xia, W; Xu, L; Xu, W; Xu, Y; Yin, R; Zhang, E | 1 |
Moritz, LE; Trievel, RC | 1 |
Fujioka, K; Hamamoto, R; Nakakido, M; Piao, L | 1 |
Copeland, RA; Harvey, D; Ribich, S | 1 |
Allahverdi, A; Chung, HH; Cukuroglu, E; Geifman-Shochat, S; Göke, J; Lin, VCL; Madhusudhan, MS; Nordenskiöld, L; Su, IH; Tan, KP; Venkatesan, N; Wong, JF; Yau, YH | 1 |
Ding, LN; Duan, YC; Guan, YY; Ma, CY; Ma, YC; Qin, WP; Yang, J; Zhai, XY; Zheng, YC; Zhu, YL | 1 |
Hanaki, Y; Hotta, N; Imoto, M; Irie, K; Kikumori, M; Shikata, Y | 1 |
Abdullah, LN; Chow, EK; Ho, JC; Jha, S; Kato, H; Lee, KL; Pang, QY; Poellinger, L; Ueda, J; Yang, H | 1 |
Chen, YX; Fang, JY; Fu, LN; Tan, J | 1 |
He, Z; Huang, J; Liu, B; Lyu, H | 1 |
Bridgeman, SC; Ellison, GC; Mamotte, CDS; Melton, PE; Newsholme, P | 1 |
Cai, S; Chen, Y; Kong, Y; Wang, Q; Xiao, D | 1 |
Di Leva, FS; Fottner, M; Kapp, TG; Kessler, H; Marelli, UK; Marinelli, L; Notni, J; Novellino, E; Räder, AFB; Reich, D; Reichart, F; Steiger, K; Wester, HJ; Wurzer, A | 1 |
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Lu, T; Stark, GR; Wang, Y | 1 |
Lyko, F; Mund, C | 1 |
Margueron, R; Reinberg, D | 1 |
Kimura, H; Okada, M; Oneyama, C; Suzuki, K; Tajima, S | 1 |
Füllgrabe, J; Joseph, B; Kavanagh, E | 1 |
Gao, M; Lola, CM; Miller, KD; Sledge, GW; Wang, M; Zheng, QH | 1 |
Bartlett, DL; Guo, ZS; Li, Q; O'Malley, ME | 1 |
Irie, K; Kikumori, M; Murakami, A; Nagai, H; Nakagawa, Y; Tokuda, H; Yanagita, RC | 1 |
Mudbhary, R; Sadler, KC | 1 |
Benevolenskaya, EV; Beshiri, ML; Blair, LP; Bronson, RT; Cao, J; Cherniack, AD; Francis, J; Fujiwara, Y; Geisen, C; Grisanzio, C; Kaelin, WG; Kawamori, D; Kulkarni, RN; Lin, W; Liu, J; Liu, Z; Meyerson, M; Minamishima, YA; Orkin, SH; Rodig, SJ; Shen, X; Signoretti, S; Tuck, DP; Watanabe, H; Yan, Q; Zhang, Q; Zou, MR | 1 |
Kohen, A; Saeed, M; Sheff, D | 1 |
Atadja, P; Dai, J; Gu, J; Li, E; Li, L; Lu, C; Luo, X; Wang, L; Zhang, H; Zhao, K; Zhou, S; Zhu, J | 1 |
Lan, R; Liu, Y; Lu, F; Quan, J; Ren, Q; Sun, H; Wang, J; Ward, D; Xu, Z; Ye, T; Zhang, H | 1 |
Fog, CK; Galli, GG; Lund, AH | 1 |
Cho, HS; Daigo, Y; Field, HI; Hamamoto, R; Hayami, S; Iwai, Y; Kelly, JD; Maehara, Y; Masuda, K; Nakamura, Y; Neal, DE; Ponder, BA; Takawa, M; Toyokawa, G; Tsuchiya, E; Tsunoda, T; Yamane, Y; Yoshimatsu, M | 1 |
Beland, FA; Koturbash, I; Pogribny, IP; Simpson, NE | 1 |
Chaussepied, M; Chluba, J; Cock-Rada, AM; Janski, N; Langsley, G; Medjkane, S; Perichon, M; Weitzman, JB; Yousfi, N | 1 |
Garber, K | 1 |
Hishiki, T; Kajimura, M; Kubo, A; Morikawa, T; Suematsu, M; Yamamoto, T | 1 |
Heber, D; Henning, SM; Wang, P | 1 |
Greer, EL; Shi, Y | 1 |
Helin, K; Kooistra, SM | 1 |
Butt, AM; Feng, D; Idrees, M; Lu, J; Tong, Y | 1 |
Gezer, U; Holdenrieder, S; Leszinski, G; Siegele, B; Stoetzer, O | 1 |
Bernstein, BE; Ryan, RJ | 1 |
Price, BD; Xu, C; Xu, Y | 1 |
Lehner, B; Schuster-Böckler, B | 1 |
La Thangue, NB; Moehlenbrink, J | 1 |
Decarlo, D; Hadden, MK | 1 |
Ikegami, D; Kim, YJ; Niwa, T; Takeshima, H; Ushijima, T; Wakabayashi, M | 1 |
Domann, FE; Hitchler, MJ | 1 |
Plevritis, SK; Qiu, P | 1 |
Kouzarides, T; Robson, SC; Xhemalce, B | 1 |
Black, JC; Whetstine, JR | 1 |
Cock-Rada, A; Weitzman, JB | 1 |
Gozani, O; Hammell, M; Joshua-Tor, L; Kuo, A; McCombie, WR; Mills, AA; Paul, S; Schalch, T; Vogel, H | 1 |
Huang, S | 1 |
Albanese, C; Balent, B; Greally, J; Neumeister, P; Pestell, RG | 1 |
Hirohashi, S; Koizume, S; Sekiya, T; Shiraishi, M; Tachibana, K | 1 |
Mills, K | 2 |
Lökk, J | 1 |
Angrand, PO; Chambon, P; Hager, GL; Lerouge, T; Losson, R; Mark, M; Niederreither, K; Rayasam, GV; Song, L; Wendling, O | 1 |
LEE, KY; LIJINSKY, W; MAGEE, PN | 1 |
CRADDOCK, VM; MAGEE, PN | 1 |
Albanes, D; Glynn, SA | 1 |
Evans, WE; Krynetski, E | 1 |
Bailey, LB | 1 |
Clarke, S; Tamanoi, F | 1 |
Albiez, H; Cremer, C; Cremer, M; Cremer, T; Stein, S; Wagler, B; Zinner, R | 1 |
Aherne, W; Kristeleit, R; Stimson, L; Workman, P | 1 |
Altamura, S; Di Bernardo, J; Fusco, A; Giancotti, V; Manfioletti, G; Rustighi, A; Sgarra, R; Tessari, MA | 1 |
Krause, E; Lödige, I; Meissner, T; Vinkemeier, U | 1 |
Bliek, J; Gaston, V; Gicquel, C; Le Bouc, Y; Maas, S; Mannens, M | 1 |
Davie, JR; Drobic, B; Dunn, KL; Espino, PS | 1 |
Borja-Aburto, VH; Calderon-Aranda, ES; Cruz-Gonzalez, MB; Del Razo, LM; Garcia-Montalvo, EA; Garcia-Vargas, GG; Valenzuela, OL | 1 |
Kean, T; Roth, S; Thanou, M | 1 |
Marx, J | 1 |
Chang, KM; Chen, IL; Chen, YL; Liao, CH; Lu, PJ; Tsiao, KC; Tzeng, CC; Wang, TC; Wong, CH | 1 |
Foley, J; Richard, V; Rosol, TJ | 1 |
Allis, CD; Coonrod, SA; Leonelli, L; Perlin, JR; Wang, Y; Wysocka, J | 1 |
Esteller, M; Fraga, MF | 1 |
Caldas, C; Santos-Rosa, H | 1 |
Bell, WC; Grizzle, WE; Heimburger, DC; Henao, OL; Jones, J; Niveleau, A; Piyathilake, CJ | 1 |
Baudler, M; Beck, JF; Benimetskaya, L; Gekeler, V; Gimmnich, P; Gonser, B; Grebe, C; Hanauer, G; Hofmann, HP; Leja, A; Maier, T; Pieles, U; Römmele, M; Sanders, K; Stein, CA; Wagner, T | 1 |
Hilgeroth, A; Molnár, J; Richter, M | 1 |
Esteller, M; Herranz, M | 2 |
Frye, M; Watt, FM | 1 |
Lee, KD; Lin, CT; Lin, WH; Tzeng, PY | 1 |
Si, LS | 1 |
Duenas-Gonzalez, A; Perez-Plasencia, C | 1 |
Hirohashi, S; Shibata, T | 1 |
Huang, SH; Krishnamohan, M; Lam, PK; Maddelena, R; Moore, MR; Ng, JC; Wu, HJ | 1 |
Ben-Shushan, E; Bergman, Y; Cedar, H; Eden, E; Farkash, S; Hecht, M; Keshet, I; Reubinoff, BE; Schlesinger, Y; Simon, I; Straussman, R; Yakhini, Z; Zimmerman, J | 1 |
Mumby, M | 1 |
Cooper, WN; Hesson, LB; Latif, F | 1 |
Beekman, C; Bracken, AP; Dietrich, N; Gargiulo, G; Hansen, KH; Helin, K; Kleine-Kohlbrecher, D; Marine, JC; Minucci, S; Pasini, D; Porse, BT; Theilgaard-Mönch, K | 1 |
An, W | 1 |
Kundu, TK; Reddy, BA; Ruthrotha Selvi, B; Sukanya, MS; Swaminathan, V | 1 |
Eisenman, RN; Secombe, J | 1 |
Chan, AT; Cui, Y; Cullen, PJ; Jin, H; Jin, J; Kupzig, S; Li, EM; Shen, ZY; Srivastava, G; Tao, Q; Wang, X; Wong, AH; Ying, J; Zhang, Q | 1 |
Pal, S; Sif, S | 1 |
Domann, FE; Provenzano, MJ | 1 |
Shi, Y | 1 |
Hanash, S | 1 |
Li, K; Teng, LJ | 1 |
Guittat, L; Nittis, T; Stewart, SA | 1 |
Morrison, Z; Wiencke, JK; Yeh, RF; Zheng, S | 1 |
Blanca, A; Carrasco, JC; Requena, MJ | 1 |
Brzozowski, Z; Innocenti, A; Kornicka, A; Pomarnacka, E; Saczewski, F; Scozzafava, A; Supuran, CT; Sławiński, J; Temperini, C | 1 |
Aas, PA; Feyzi, E; Krokan, HE; Otterlei, M; Slupphaug, G; Sundheim, O; Vågbø, CB; Westbye, MP | 1 |
Agger, K; Christensen, J; Cloos, PA; Helin, K | 1 |
Chuang, HC; Gaffney, KJ; Kardosh, A; Petasis, NA; Schönthal, AH | 1 |
Hancock, RL | 2 |
Cheah, MS; Hoffman, RM; Wallace, CD | 1 |
Feinberg, AP; Vogelstein, B | 2 |
Erb, N; Heller-Schöch, G; Lorenz, H; Müller, J; Schöch, G; Winkler, K | 1 |
Hoffman, RM | 3 |
Carlow, DA; Elliott, BE; Frost, P; Kerbel, RS; Liteplo, R | 1 |
Bynum, GD; Day, RS; Galloway, SM; Girardi, AJ; Lubiniecki, AS; Meyer, SA; Scudiero, DA; Ziolkowski, CH | 1 |
Ehrlich, M; Gama-Sosa, MA; Gehrke, CW; Kuo, KC; Oxenhandler, R; Slagel, VA; Trewyn, RW | 1 |
Magee, PN; Nyce, J; Weinhouse, S | 1 |
Nicolson, GL | 1 |
Frost, P; Kerbel, RS | 1 |
Razin, A; Szyf, M | 1 |
Montgomery, JA; Prejean, JD | 1 |
Lo, AC; Nazar, RN; Sitz, TO; Wildeman, AG | 1 |
Coe, AM; Mace, R; Swann, PF | 1 |
Borek, E | 2 |
Kleihues, P; Uozumi, A; Wiestler, OD | 1 |
Cline, MJ; deKernion, JB; Slamon, DJ; Verma, IM | 1 |
Cheah, MS; Diala, ES; Hoffman, RM; Rowitch, D | 1 |
Reitz, RH; Watanabe, PG | 1 |
Day, RS; Yagi, T; Yarosh, DB | 1 |
Pegg, AE | 1 |
Agrawal, HP; Randerath, E; Randerath, K | 1 |
Borek, E; Sharma, OK; Waalkes, TP | 1 |
Hanski, C; Stehlik, G | 1 |
Beck, BD; Boardman, PD; Carlson-Lynch, H | 1 |
Bhagwat, AS; Yebra, MJ | 1 |
Deal, CL | 1 |
Little, M; Wainwright, B | 1 |
Baylin, SB; Burger, PC; Gabrielson, E; Herman, JG; Lee, DJ; Mao, L; Merlo, A; Sidransky, D | 1 |
Christman, JK | 1 |
Grigg, GW; Holliday, R | 1 |
Pfeifer, GP; Tornaletti, S | 1 |
Mishina, M; Ogawa, O; Yoshida, O | 1 |
Miwa, W; Sekine, T; Sekiya, T; Yashima, K | 1 |
Doerfler, W | 1 |
Bignami, M; Karran, P | 1 |
Jaenisch, R; Laird, PW | 1 |
Rogers, AE | 1 |
Counts, JL; Goodman, JI | 3 |
Feinberg, AP; Rainier, S | 1 |
Jones, PA; Magewu, AN | 1 |
Bolt, HM; Gansewendt, B | 1 |
De-Groot, N; Hochberg, A | 1 |
Pourcel, C | 1 |
Feinberg, AP | 2 |
Dosch, J; Fritz, G; Kaina, B; Thielmann, HW | 1 |
Holliday, R | 3 |
Jones, PA; Rideout, WM; Spruck, CH | 1 |
Briggs, RS; Ganderton, RH | 1 |
Schwab, M | 1 |
Balmain, A | 1 |
Brugger, W; Kanz, L; Lübbert, M; Mertelsmann, R | 1 |
DeBaun, MR; Feinberg, AP; Rainier, S | 1 |
Christensen, B | 1 |
MacLeod, MC | 1 |
Heby, O | 1 |
Jones, PA | 3 |
Kunkel, TA; Umar, A | 1 |
Boon, T; Brasseur, F; De Backer, O; De Smet, C; Faraoni, I; Lurquin, C | 1 |
Sakai, T | 1 |
Beck, BD; Chapnick, SD; Gauthier, TD; Jones, L; Reynolds, KA; Schoof, RA; Slayton, TM; Valberg, PA; Yost, LJ | 1 |
Maclennan, R; Nixon, P; Seitz, HK; Watson, RR | 1 |
Kaiser, J | 1 |
Biggs, ML; Ferreccio, C; Haque, R; Hopenhayn-Rich, C; Moore, L; Smith, A | 1 |
Ip, C | 1 |
Ganther, HE | 1 |
Collins, JM; Katki, AG; Klecker, RW | 1 |
Fearon, ER | 1 |
Baylin, SB; Belinsky, SA; Herman, JG | 1 |
Ahmad, S; Cullen, WR; Kitchin, KT | 1 |
Prokhorchuk, AV; Ruzov, AS | 1 |
Issa, JP; Kantarjian, HM; Santini, V | 1 |
Kitchin, KT | 1 |
Allis, CD; Rice, JC | 1 |
Pennisi, E | 1 |
Chen, CJ; Chiou, HY; Hsueh, YM; Lee, TC; Wang, IH; Wang, TW; Wu, MM | 1 |
Mathé, G | 1 |
Uchida, T | 1 |
Zhu, BT | 1 |
Lakings, DB; Mrochek, JE; Waalkes, TP | 1 |
Boiteux, S; Glickman, BW; Kinsella, AR; Radman, M; Spadari, S; Villani, G | 1 |
Nau, F | 1 |
Weinhouse, S | 1 |
Guldberg, HC; Marsden, CA | 1 |
Levine, L; Stolbach, L; Waalkes, TP | 1 |
Sasaki, H | 1 |
Baylin, SB | 1 |
Jones, PA; Rideout, WM; Shen, JC; Spruck, CH; Tsai, YC | 1 |
Biassoni, D; Borrello, MG; Della Porta, G; Pierotti, MA; Pilotti, S; Rizzetti, MG; Tamborini, E | 1 |
Baylin, SB; de Bustros, A; Makos, M; Nelkin, BD; Vertino, P; Wu, JJ; Yen, RW | 1 |
Hall, JG | 1 |
DiMaria, P; Duerre, JA; Kim, S; Paik, WK | 1 |
Bartsch, H; Calmels, S; Ohshima, H; Pignatelli, B; Shuker, DE | 1 |
Liehr, JG; Roy, D; Weisz, J | 1 |
Buckley, JD; Jones, PA | 1 |
Kourides, IA; Whitfield, GK | 1 |
Kerr, SJ | 1 |
Frost, P; Kerbel, RS; Liteplo, R | 1 |
Newberne, PM; Rogers, AE | 1 |
Barbieri, R; del Senno, L; Gambari, R; Piva, MR | 1 |
Chandler, LA; Jones, PA | 1 |
Shire, JG | 1 |
Carcassonne, Y; Confort-Gouny, S; Favre, R; Fontanarava, E; Grisoli, F; Harlé, JR; Kriat, M; Mongin, M; Sciaky, M; Vion-Dury, J | 1 |
Evans, HJ | 1 |
Benham, DF; Busby, MJ; Glickson, JD; McLennan, I; Verdery, RB; Wehrle, JP | 1 |
Enoki, Y; Niwa, O; Yokoro, K | 1 |
Fritzsche, H; Jahn, H; Jorke, D; Sprinz, H | 1 |
Barbieri, R; Buzzoni, D; del Senno, L; Gambari, R; Giacomini, P; Mischiati, C; Nastruzzi, C; Natali, PG; Orlando, P; Piva, R | 1 |
Baylin, SB; de Bustros, A; Ehrlich, G; Nelkin, BD; Poiesz, B; Silverman, A | 1 |
Fearon, ER; Hamilton, SR; Michelson, AM; Orkin, SH; Preisinger, AC; Riggs, AD; Vogelstein, B; Willard, HF | 1 |
Reik, W; Surani, MA | 1 |
Ehrlich, M; Wang, RY; Zhang, XY | 1 |
Guirguis, RA; Liotta, LA; Schiffmann, E | 1 |
Frost, P; Kendal, WS | 1 |
Spandidos, DA | 1 |
Bogenmann, E; Chandler, LA; DeClerck, YA; Jones, PA | 1 |
Munholland, JM; Nazar, RN | 1 |
Frost, P; Kerbel, RS; Liteplo, RG | 1 |
Chorváth, B; Duraj, J; Sedlák, J | 1 |
van der Westhuyzen, J | 1 |
Ivankovic, S; Schmähl, D; Zeller, WJ | 1 |
Kaye, AM; Leboy, PS | 1 |
McCarty, KS | 1 |
Karlsson, KA; Pascher, I; Pimlott, W; Samuelsson, BE | 1 |
Gantt, RR | 1 |
Evans, VJ; Gantt, R | 1 |
Datta, B; Datta, RK | 1 |
Craddock, VM | 1 |
Magee, PN | 1 |
Zamecnik, PC | 1 |
Hacker, B; Maag, TA; Mandel, LR | 1 |
Pillinger, DJ; Wilkinson, R | 1 |
332 review(s) available for isomethyleugenol and Neoplasms
Article | Year |
---|---|
Cross-Talk between Oxidative Stress and m
Topics: Humans; Methylation; Neoplasms; Oxidative Stress; RNA | 2021 |
Embryonic Ectoderm Development (EED) as a Novel Target for Cancer Treatment.
Topics: Allosteric Site; Animals; Histones; Humans; Methylation; Molecular Targeted Therapy; Neoplasms; Polycomb Repressive Complex 2 | 2021 |
Cellular pathways influenced by protein arginine methylation: Implications for cancer.
Topics: Alternative Splicing; Animals; Arginine; B7-H1 Antigen; Cell Communication; Cell Line, Tumor; CRISPR-Cas Systems; DNA Damage; DNA Repair; Enzyme Inhibitors; Epigenesis, Genetic; Histones; Humans; Immune System; Immunotherapy; Methylation; Mice; Mice, Knockout; Neoplasms; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; RNA Splicing; RNA, Messenger; Signal Transduction | 2021 |
RNA methylation and cancer treatment.
Topics: Animals; Humans; Methylation; Neoplasms; RNA | 2021 |
Genes of the month: H3.3 histone genes: H3F3A and H3F3B.
Topics: Acetylation; Animals; Chromatin Assembly and Disassembly; DNA Methylation; Genetic Predisposition to Disease; Histones; Humans; Methylation; Mutation; Neoplasms; Neurodevelopmental Disorders; Protein Processing, Post-Translational | 2021 |
The role of OncoSnoRNAs and Ribosomal RNA 2'-O-methylation in Cancer.
Topics: Animals; Humans; Methylation; Neoplasms; Ribosomes; RNA Processing, Post-Transcriptional; RNA, Ribosomal; RNA, Small Nucleolar | 2021 |
N6-Methyladenosine RNA Modification in the Tumor Immune Microenvironment: Novel Implications for Immunotherapy.
Topics: Adenosine; Animals; Humans; Immunotherapy; Methylation; Neoplasms; RNA; Tumor Microenvironment | 2021 |
Molecular mechanisms in governing genomic stability and tumor suppression by the SETD2 H3K36 methyltransferase.
Topics: Animals; Carcinogenesis; Chromatin; Genomic Instability; Histones; Humans; Lysine; Mammals; Methylation; Neoplasms | 2022 |
The role of m6A RNA methylation in cancer metabolism.
Topics: Adenosine; Animals; Biomarkers; Disease Management; Disease Susceptibility; Energy Metabolism; Gene Expression Regulation, Neoplastic; Humans; Methylation; Mitochondria; Neoplasms; RNA; RNA Processing, Post-Transcriptional; RNA, Circular; RNA, Messenger; RNA, Untranslated; Signal Transduction; Transcription Factors | 2022 |
Advances in the functional roles of N6-methyladenosine modification in cancer progression: mechanisms and clinical implications.
Topics: Adenosine; Humans; Methylation; Neoplasms; RNA, Messenger | 2022 |
Molecular Mechanisms of lncRNAs in the Dependent Regulation of Cancer and Their Potential Therapeutic Use.
Topics: Animals; Biomarkers, Tumor; Carcinogenesis; Disease Management; Disease Susceptibility; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genetic Engineering; Genetic Predisposition to Disease; Genetic Therapy; Histones; Humans; Methylation; Molecular Targeted Therapy; Neoplasms; Oncogenes; Protein Processing, Post-Translational; RNA Processing, Post-Transcriptional; RNA, Long Noncoding | 2022 |
Insights into N6-methyladenosine and programmed cell death in cancer.
Topics: Adenosine; Apoptosis; Humans; Methylation; Neoplasms | 2022 |
Potential applications of N
Topics: Apoptosis; Autophagy; Carcinogenesis; Ferroptosis; Humans; Methylation; Neoplasms | 2022 |
Functions, mechanisms, and therapeutic implications of METTL14 in human cancer.
Topics: Adenine; Animals; Carcinogenesis; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; Neoplasms; Prognosis; RNA | 2022 |
Protein Arginine Methyltransferases in Neuromuscular Function and Diseases.
Topics: Antineoplastic Agents; Humans; Methylation; Neoplasms; Neuromuscular Diseases; Protein-Arginine N-Methyltransferases; Quality of Life | 2022 |
Emerging roles of JMJD3 in cancer.
Topics: Apoptosis; Female; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Neoplasms | 2022 |
Exploring Methods of Targeting Histone Methyltransferases and Their Applications in Cancer Therapeutics.
Topics: Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Methyltransferases; Neoplasms | 2022 |
Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy.
Topics: Arginine; Humans; Immunologic Factors; Immunotherapy; Methylation; Neoplasms; Protein-Arginine N-Methyltransferases; Quality of Life | 2022 |
The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer.
Topics: Adenosine; Humans; Methylation; Neoplasms; RNA-Binding Proteins; RNA, Messenger | 2022 |
Chemical biology and pharmacology of histone lysine methylation inhibitors.
Topics: Biology; Epigenesis, Genetic; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Neoplasms; Protein Processing, Post-Translational | 2022 |
Crosstalk among m
Topics: Ecosystem; Humans; Hypoxia; Methylation; Neoplasms; RNA; Tumor Microenvironment | 2022 |
Targeting histone demethylases as a potential cancer therapy (Review).
Topics: Histone Demethylases; Histones; Humans; Lysine; Methylation; Neoplasms | 2022 |
Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance.
Topics: Adenosine; Drug Resistance, Neoplasm; Humans; Methylation; Neoplasms; RNA, Circular | 2022 |
The Epitranscriptome in miRNAs: Crosstalk, Detection, and Function in Cancer.
Topics: Humans; Methylation; MicroRNAs; Neoplasms; RNA Processing, Post-Transcriptional | 2022 |
Protein Lysine Methyltransferase SMYD2: A Promising Small Molecule Target for Cancer Therapy.
Topics: Histone-Lysine N-Methyltransferase; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational | 2022 |
Research progress of m
Topics: Adenosine; Animals; Growth and Development; Humans; Methylation; Neoplasms; RNA; RNA, Messenger | 2022 |
The Role of RNA m
Topics: Adenosine; Glycolysis; Humans; Methylation; Neoplasms; RNA; Tumor Microenvironment | 2023 |
Impact of N6-methyladenosine (m
Topics: Adenosine; Humans; Methylation; Methyltransferases; Neoplasms | 2022 |
Role of WTAP in Cancer: From Mechanisms to the Therapeutic Potential.
Topics: Cell Cycle Proteins; Humans; Methylation; Methyltransferases; Neoplasms; RNA; RNA Splicing Factors; RNA, Messenger | 2022 |
The role of lncRNA just proximal to XIST (JPX) in human disease phenotypes and RNA methylation: The novel biomarker and therapeutic target potential.
Topics: Biomarkers; Humans; Methylation; Neoplasms; Phenotype; RNA, Long Noncoding | 2022 |
[Research Progress of m6A Methylation Modification in Hematological Tumors--Review].
Topics: Adenosine; Epigenesis, Genetic; Hematologic Neoplasms; Humans; Methylation; Neoplasms; RNA, Messenger | 2022 |
Emerging role of mRNA methylation in regulating the hallmarks of cancer.
Topics: DNA; Humans; Methylation; Methyltransferases; Neoplasms; RNA; RNA Processing, Post-Transcriptional; RNA, Messenger | 2023 |
RNA m
Topics: Humans; Methylation; Neoplasms; RNA; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Untranslated | 2023 |
Protein arginine methyltransferase 3: A crucial regulator in metabolic reprogramming and gene expression in cancers.
Topics: Arginine; Gene Expression; Humans; Methylation; Neoplasms; Protein-Arginine N-Methyltransferases | 2023 |
Biological roles of the RNA m
Topics: Adenosine; Humans; Methylation; Neoplasms; RNA; RNA, Messenger | 2022 |
RNA methylation and cellular response to oxidative stress-promoting anticancer agents.
Topics: Animals; Antineoplastic Agents; Epigenesis, Genetic; Epigenome; Homeostasis; Humans; Methylation; Mitochondria; Neoplasms; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Recurrence; RNA; RNA Processing, Post-Transcriptional; Transcriptome | 2023 |
Roles of RNA Methylations in Cancer Progression, Autophagy, and Anticancer Drug Resistance.
Topics: Antineoplastic Agents; Autophagy; Humans; Methylation; Neoplasms; RNA | 2023 |
When N
Topics: Humans; Methylation; MicroRNAs; Neoplasms; RNA, Messenger; RNA, Transfer | 2023 |
RNA modifications in cancer.
Topics: Humans; Methylation; Neoplasms; RNA; RNA Processing, Post-Transcriptional; RNA, Messenger | 2023 |
Advances in targeting RNA modifications for anticancer therapy.
Topics: Animals; Carcinogenesis; Humans; Mammals; Methylation; Methyltransferases; Neoplasms; RNA; RNA, Messenger | 2023 |
The roles of EZH2 in cancer and its inhibitors.
Topics: Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Methylation; Neoplasms; Polycomb Repressive Complex 2 | 2023 |
The roles and mechanism of m
Topics: Adenosine; Humans; Methylation; Methyltransferases; Neoplasms; RNA; Tumor Microenvironment | 2023 |
The emerging role of N
Topics: Carcinogenesis; Humans; Ions; Metals, Heavy; Methylation; Neoplasms; RNA, Messenger | 2023 |
The role of m6A methylation in therapy resistance in cancer.
Topics: Epigenesis, Genetic; Humans; Methylation; Neoplasms; RNA; RNA Splicing | 2023 |
Roles and implications of mRNA N
Topics: Epigenesis, Genetic; Humans; Methylation; Neoplasms; RNA; RNA, Messenger | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide | 2023 |
Methyltransferase-like proteins in cancer biology and potential therapeutic targeting.
Topics: Adenosine; Biology; Humans; Methylation; Methyltransferases; MicroRNAs; Neoplasms | 2023 |
Crosstalk between m6A modification and alternative splicing during cancer progression.
Topics: Alternative Splicing; Animals; Mammals; Methylation; Neoplasms; RNA; RNA-Binding Proteins; RNA, Messenger | 2023 |
The role of N6-methyladenosine methylation in PAHs-induced cancers.
Topics: Biomarkers; Humans; Methylation; Neoplasms; RNA | 2023 |
Effects of RNA methylation on Tumor angiogenesis and cancer progression.
Topics: Humans; Methylation; Neoplasms; Neovascularization, Pathologic; RNA | 2023 |
Reading, writing and erasing mRNA methylation.
Topics: Adenosine; Animals; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Neoplasm | 2019 |
Lysine Methylation Regulators Moonlighting outside the Epigenome.
Topics: Animals; Epigenome; Humans; Lysine; Methylation; Neoplasm Proteins; Neoplasms; Protein Processing, Post-Translational; Signal Transduction | 2019 |
Epigenetic Alterations of Heat Shock Proteins (HSPs) in Cancer.
Topics: Animals; Apoptosis; Biomarkers, Tumor; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; Histones; Humans; Methylation; MicroRNAs; Molecular Targeted Therapy; Neoplasms; Protein Processing, Post-Translational | 2019 |
[Reactive Oxygen Species (ROS) Signaling: Regulatory Mechanisms and Pathophysiological Roles].
Topics: Adenosine Triphosphate; Alarmins; Apoptosis; Atherosclerosis; Humans; Inflammation; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 5; Methylation; Neoplasms; Neurodegenerative Diseases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Reactive Oxygen Species; Signal Transduction; Trans Fatty Acids; Ubiquitin-Protein Ligases; Ubiquitination | 2019 |
The interplay between m6A RNA methylation and noncoding RNA in cancer.
Topics: Adenosine; Humans; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Neoplasm; RNA, Untranslated | 2019 |
Functions of N6-methyladenosine and its role in cancer.
Topics: Adenosine; Animals; Biomarkers; Disease Susceptibility; Gene Expression Regulation, Neoplastic; Humans; Methylation; Molecular Targeted Therapy; Neoplasms; Protein Binding; RNA, Messenger; Signal Transduction | 2019 |
Lysine Methyltransferases Signaling: Histones are Just the Tip of the Iceberg.
Topics: Chromosomal Proteins, Non-Histone; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histones; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Neoplasms; Protein Processing, Post-Translational; Signal Transduction | 2020 |
New sights in cancer: Component and function of N6-methyladenosine modification.
Topics: Adenosine; Animals; Epigenesis, Genetic; Humans; Methylation; Neoplasms; RNA; RNA, Messenger | 2020 |
Post-translational modifications of protein in response to ionizing radiation.
Topics: Amino Acid Motifs; DNA Damage; Genome, Human; Glycosylation; Humans; Methylation; Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Proteins; Radiation, Ionizing; Signal Transduction; Ubiquitination | 2020 |
Drugging histone methyltransferases in cancer.
Topics: Antineoplastic Agents; Carcinogenesis; Chromatin; Drug Design; Drug Therapy, Combination; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Expression Regulation; Histone Methyltransferases; Humans; Methylation; Mutation; Neoplasms | 2020 |
m
Topics: Disease Progression; Homeostasis; Humans; Methylation; Neoplasms; RNA, Messenger; Transcriptome | 2020 |
Small Molecules Targeting the Specific Domains of Histone-Mark Readers in Cancer Therapy.
Topics: Acetylation; Animals; Antineoplastic Agents; Drug Delivery Systems; Epigenesis, Genetic; Histone Code; Humans; Methylation; Neoplasms; Protein Binding; Protein Domains | 2020 |
Advances into understanding metabolites as signaling molecules in cancer progression.
Topics: Acetylation; Animals; Disease Progression; Glycosylation; Humans; Metabolome; Methylation; Neoplasm Proteins; Neoplasms; Protein Processing, Post-Translational; Signal Transduction | 2020 |
Non-Histone Arginine Methylation by Protein Arginine Methyltransferases.
Topics: Antineoplastic Agents; Arginine; Cardiovascular Diseases; Enzyme Inhibitors; Epigenesis, Genetic; Histones; Humans; Metabolic Diseases; Methylation; Neoplasms; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; RNA Splicing; Signal Transduction; Transcription Factors | 2020 |
Diverse molecular functions of m
Topics: Adenosine; Alternative Splicing; Animals; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; Nucleic Acid Conformation; Organ Specificity; RNA Processing, Post-Transcriptional; RNA Stability; RNA, Messenger; Structure-Activity Relationship | 2020 |
Drug Resistance in Cancer Therapy and the Role of Epigenetics.
Topics: Acetylation; Antigens, Neoplasm; Antineoplastic Agents; DNA Repair; Drug Resistance, Neoplasm; Epigenomics; Gene Expression; Histones; Humans; Membrane Transport Proteins; Methylation; Molecular Targeted Therapy; Neoplasms | 2020 |
Targeting post-translational modification of transcription factors as cancer therapy.
Topics: Acetylation; Animals; Humans; Methylation; Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Transcription Factors | 2020 |
EZH2: a novel target for cancer treatment.
Topics: Adenosine; Antineoplastic Agents; Benzamides; Biphenyl Compounds; Cell Cycle; Cell Transformation, Neoplastic; Clinical Trials as Topic; Combined Modality Therapy; Drug Resistance, Neoplasm; Enhancer of Zeste Homolog 2 Protein; Epigenetic Repression; Histone Code; Histones; Humans; Methylation; Morpholines; Multicenter Studies as Topic; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Polycomb Repressive Complex 2; Pyridones; Structure-Activity Relationship; Transcriptional Activation; Tumor Microenvironment | 2020 |
Novel insights into the interplay between m
Topics: Adenosine; Animals; Carcinogenesis; Disease Susceptibility; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Methylation; MicroRNAs; Neoplasms; RNA Interference; RNA, Circular; RNA, Long Noncoding; RNA, Messenger; RNA, Untranslated | 2020 |
The Ubiquitin-Proteasome Pathway and Epigenetic Modifications in Cancer.
Topics: Acetylation; Boron Compounds; Bortezomib; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Glycine; Histone Acetyltransferases; Histone Deacetylases; Humans; Hydroxamic Acids; Methylation; Neoplasms; NF-kappa B; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Signal Transduction; Terphenyl Compounds; Ubiquitin; Ubiquitination; Valproic Acid | 2021 |
Roles of METTL3 in cancer: mechanisms and therapeutic targeting.
Topics: Adenosine; Antineoplastic Agents; Binding, Competitive; Carcinogens; Drug Design; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; Models, Molecular; Molecular Targeted Therapy; Neoplasm Proteins; Neoplasms; Oncogenes; Protein Conformation; Protein Domains; Recombinant Fusion Proteins; RNA Processing, Post-Transcriptional; RNA, Neoplasm; Substrate Specificity; Tumor Suppressor Proteins | 2020 |
Surmounting cancer drug resistance: New insights from the perspective of N
Topics: Adenosine; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Disease Models, Animal; DNA Damage; DNA Repair; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Immune Checkpoint Inhibitors; Methylation; Neoplasms; Protein Kinase Inhibitors; RNA Processing, Post-Transcriptional; Treatment Outcome; Tumor Microenvironment | 2020 |
Principles of RNA methylation and their implications for biology and medicine.
Topics: Adenine; AlkB Homolog 5, RNA Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Humans; Methylation; Neoplasms; RNA; RNA Processing, Post-Transcriptional; Spermatogenesis; T-Lymphocytes; Virus Diseases | 2020 |
Perspectives Regarding the Intersections between STAT3 and Oxidative Metabolism in Cancer.
Topics: Acetylation; Cell Respiration; Humans; Methylation; Mitochondria; Neoplasms; Oxidation-Reduction; Oxidative Stress; Peroxidases; Phosphorylation; Protein Processing, Post-Translational; STAT3 Transcription Factor | 2020 |
N
Topics: Adenosine; Animals; Disease Progression; Humans; Methylation; Methyltransferases; Neoplasms; RNA, Messenger | 2020 |
Histone Methyltransferase SETDB1: A Common Denominator of Tumorigenesis with Therapeutic Potential.
Topics: Carcinogenesis; Down-Regulation; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplasm Proteins; Neoplasms; Protein Processing, Post-Translational; Repressor Proteins; Transcription, Genetic | 2021 |
Methylation of histone 4's lysine 20: a critical analysis of the state of the field.
Topics: Animals; Cell Cycle; Embryonic Development; Histones; Humans; Lysine; Methylation; Neoplasms | 2021 |
RNA methylations in human cancers.
Topics: Animals; Biomarkers, Tumor; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms | 2021 |
Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes.
Topics: Animals; Chromatin; Deubiquitinating Enzymes; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms; Polycomb-Group Proteins; Ubiquitination | 2020 |
Novel Insights Into the Role of N6-Methyladenosine RNA Modification in Bone Pathophysiology.
Topics: Adenosine; Bone and Bones; Cartilage; Humans; Methylation; MicroRNAs; Neoplasms; RNA; RNA, Long Noncoding; RNA, Messenger | 2021 |
Regulation of processing bodies: From viruses to cancer epigenetic machinery.
Topics: Animals; Cytoplasm; Epigenesis, Genetic; Gene Expression Regulation; Humans; Methylation; MicroRNAs; Neoplasms; Organelles; Protein Processing, Post-Translational; Ribonucleoproteins; RNA, Messenger; Viruses | 2021 |
Non-Histone Protein Methylation: Biological Significance and Bioengineering Potential.
Topics: Alzheimer Disease; Animals; Bioengineering; Cell Cycle; Humans; Methylation; Mitochondria; Neoplasms; Protein Processing, Post-Translational; Proteins | 2021 |
PRMT5 and Tip60 Modify FOXP3 Function in Tumor Immunity.
Topics: Arginine; Epigenesis, Genetic; Forkhead Transcription Factors; Humans; Methylation; Neoplasms; Protein-Arginine N-Methyltransferases | 2020 |
Serine, glycine and one‑carbon metabolism in cancer (Review).
Topics: Animals; Antineoplastic Agents; Carbon; Carcinogenesis; Disease Models, Animal; Glycine; Humans; Metabolic Networks and Pathways; Methylation; Mice; Neoplasms; Oxidation-Reduction; Serine; Tumor Microenvironment; Warburg Effect, Oncologic | 2021 |
Mechanistic insights into KDM4A driven genomic instability.
Topics: Animals; Cell Transformation, Neoplastic; Genomic Instability; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Neoplasms; Protein Processing, Post-Translational; Signal Transduction | 2021 |
The role of m6A modification in the biological functions and diseases.
Topics: Adenosine; Epigenesis, Genetic; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Methylation; Methyltransferases; Neoplasms; Nerve Tissue Proteins; RNA Processing, Post-Transcriptional; RNA Splicing Factors; RNA-Binding Proteins | 2021 |
Epigenetics and Its Ethical Implications.
Topics: Diabetes Mellitus, Type 2; Epigenesis, Genetic; Gene Expression Regulation; Genetic Predisposition to Disease; Germ Cells; Histones; Humans; Methylation; Neoplasms; Neurodegenerative Diseases; Obesity; Phenotype | 2021 |
Effects of m6A modifications on signaling pathways in human cancer (Review).
Topics: Adenosine; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; RNA Processing, Post-Transcriptional; Signal Transduction | 2021 |
Coordinated methyl readers: Functional communications in cancer.
Topics: Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms | 2022 |
Roles of RNA Methylation on Tumor Immunity and Clinical Implications.
Topics: Animals; Humans; Immunity, Innate; Methylation; Neoplasms; RNA Splicing; RNA, Messenger; RNA, Neoplasm | 2021 |
Posttranslational modification of pyruvate kinase type M2 (PKM2): novel regulation of its biological roles to be further discovered.
Topics: Acetylation; Carrier Proteins; Cell Line, Tumor; Glycolysis; Humans; Membrane Proteins; Methylation; Neoplasms; Protein Processing, Post-Translational; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Warburg Effect, Oncologic | 2021 |
N
Topics: Adenosine; Humans; Methylation; Neoplasms; RNA; RNA, Messenger | 2021 |
Oncohistones: a roadmap to stalled development.
Topics: Antineoplastic Agents; Carcinogenesis; Cell Differentiation; Chromatin; Complementary Therapies; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Molecular Targeted Therapy; Mutation; Neoplasms; Neoplastic Stem Cells; Oncogenes; Polycomb-Group Proteins; Protein Processing, Post-Translational | 2022 |
Protein arginine methyltransferases: promising targets for cancer therapy.
Topics: Antineoplastic Agents; Arginine; Biomarkers, Tumor; Cell Cycle; Disease Management; Disease Susceptibility; DNA Damage; Drug Development; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Methylation; Molecular Targeted Therapy; Neoplasms; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases | 2021 |
Cancer synthetic vulnerabilities to protein arginine methyltransferase inhibitors.
Topics: Arginine; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases | 2021 |
Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer.
Topics: Humans; Methylation; NAD; Neoplasm Proteins; Neoplasms; Neoplastic Stem Cells; Niacinamide; Nicotinamide N-Methyltransferase | 2021 |
Biochemical perspectives on targeting KMT2 methyltransferases in cancer.
Topics: DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Humans; Methylation; Myeloid-Lymphoid Leukemia Protein; Neoplasms | 2021 |
Interactions between m6A modification and miRNAs in malignant tumors.
Topics: Adenosine; Animals; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; MicroRNAs; Neoplasms; RNA Processing, Post-Transcriptional | 2021 |
m6A RNA methylation and beyond - The epigenetic machinery and potential treatment options.
Topics: Epigenesis, Genetic; Epigenomics; Epithelial-Mesenchymal Transition; Gene Expression Profiling; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional; Stem Cells | 2021 |
METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth.
Topics: Animals; Carrier Proteins; Histidine; Humans; Methylation; Methyltransferases; Neoplasm Proteins; Neoplasms; Protein Processing, Post-Translational | 2021 |
The Emerging Roles of RNA m
Topics: Adenosine; Animals; Demethylation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; RNA | 2021 |
Regulation of autophagy by protein methylation and acetylation in cancer.
Topics: Acetylation; Autophagy; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational | 2022 |
RNA methylation in mammalian development and cancer.
Topics: Adenosine; Animals; Cell Differentiation; Methylation; Neoplasms; RNA | 2021 |
Decoding m
Topics: Adenosine; Animals; Gene Expression; Humans; Methylation; Neoplasms; Protein Domains; RNA Processing, Post-Transcriptional; RNA, Messenger | 2021 |
CircRNAs and their regulatory roles in cancers.
Topics: Animals; Biomarkers, Tumor; Disease Susceptibility; Gene Expression Regulation, Neoplastic; Humans; Methylation; MicroRNAs; Molecular Diagnostic Techniques; Neoplasms; Protein Biosynthesis; RNA Stability; RNA, Circular; RNA, Messenger; Transcription, Genetic | 2021 |
Molecular Pathways: Metabolic Control of Histone Methylation and Gene Expression in Cancer.
Topics: Acetylation; Cell Transformation, Neoplastic; Chromatin; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Metabolic Networks and Pathways; Methylation; Neoplasms | 2017 |
Arsenic metabolism and cancer risk: A meta-analysis.
Topics: Arsenic; Environmental Pollutants; Humans; Methylation; Neoplasms; Odds Ratio; Risk | 2017 |
One-carbon metabolism in cancer.
Topics: Amino Acids; Carbon; Humans; Metabolic Networks and Pathways; Methylation; NAD; NADP; Neoplasms; Nucleotides | 2017 |
Roles of RNA methylation by means of N
Topics: Adenosine; Gene Expression Regulation; Humans; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional | 2017 |
Structure, mechanism, and regulation of polycomb-repressive complex 2.
Topics: Animals; Crystallography, X-Ray; Gene Silencing; Humans; Methylation; Neoplasms; Polycomb Repressive Complex 2; Protein Conformation | 2018 |
Regulation of poly(ADP-Ribose) polymerase 1 functions by post-translational modifications.
Topics: Acetylation; Animals; DNA Damage; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Protein Processing, Post-Translational | 2018 |
Drug Discovery and Chemical Biology of Cancer Epigenetics.
Topics: Acetylation; DNA (Cytosine-5-)-Methyltransferases; Drug Discovery; Endosomal Sorting Complexes Required for Transport; Enzyme Inhibitors; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms | 2017 |
Epigenetic mechanism of survivin dysregulation in human cancer.
Topics: Acetylation; Antineoplastic Agents; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Neoplasms; Promoter Regions, Genetic; Survivin; Transcription Factors | 2018 |
Epigenetic effects of metformin: From molecular mechanisms to clinical implications.
Topics: Acetylation; Animals; Anticarcinogenic Agents; Diabetes Complications; Diabetes Mellitus, Type 2; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Histones; Humans; Hypoglycemic Agents; Metformin; Methylation; MicroRNAs; Models, Biological; Neoplasms; Protein Processing, Post-Translational | 2018 |
Multiple functions of m
Topics: Humans; Methylation; Neoplasms; RNA | 2018 |
STAT3, stem cells, cancer stem cells and p63.
Topics: Animals; Cellular Reprogramming; Human Embryonic Stem Cells; Humans; Methylation; Mice; MicroRNAs; Mouse Embryonic Stem Cells; Neoplasms; Neoplastic Stem Cells; Phosphorylation; STAT3 Transcription Factor; Transcription Factors; Tumor Suppressor Proteins | 2018 |
The Role of Dynamic m
Topics: Adenosine; Circadian Clocks; DNA Damage; DNA Repair; Humans; Methylation; Neoplasms; RNA; Stem Cells; Ultraviolet Rays | 2019 |
Mechanism of N
Topics: Adenosine; Animals; Histone Demethylases; Humans; Methylation; Methyltransferases; Neoplasms; RNA; RNA Editing | 2018 |
Association between H3K4 methylation and cancer prognosis: A meta-analysis.
Topics: Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms; Prognosis; Protein Processing, Post-Translational | 2018 |
RNA-modifying proteins as anticancer drug targets.
Topics: Animals; Antineoplastic Agents; Humans; Methylation; Neoplasms; RNA; RNA, Messenger | 2018 |
Radiation biology and oncology in the genomic era.
Topics: Acetylation; Cytokines; DNA Methylation; Epigenesis, Genetic; Forecasting; Genetic Markers; Genomics; Histone Acetyltransferases; Humans; Medical Oncology; Methylation; Neoplasms; Precision Medicine; Radiation Tolerance; Radiobiology; Tumor Microenvironment | 2018 |
KDM1A microenvironment, its oncogenic potential, and therapeutic significance.
Topics: Disease Progression; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Histone Demethylases; Histones; Humans; Methylation; Neoplasms; Tumor Microenvironment | 2018 |
Methylation of RNA N
Topics: Adenosine; Animals; Carcinogenesis; Cytokines; Humans; Methylation; Neoplasms; RNA | 2019 |
Endometriosis.
Topics: Adolescent; Adult; Endometriosis; Endometrium; Female; Humans; Methylation; Middle Aged; Neoplasms; Pain; Quality of Life | 2018 |
The dual role of N6-methyladenosine modification of RNAs is involved in human cancers.
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Carcinogenesis; Disease Progression; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genetic Therapy; Humans; Methylation; Methyltransferases; Molecular Targeted Therapy; Neoplasms; RNA Editing; RNA, Neoplasm | 2018 |
Recognition of cancer mutations in histone H3K36 by epigenetic writers and readers.
Topics: Epigenomics; Histones; Humans; Methylation; Mutation; Neoplasms; Transcription, Genetic | 2018 |
Metabolic Signaling to the Nucleus in Cancer.
Topics: Acetylation; Animals; Carcinogenesis; Cell Nucleus; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation, Neoplastic; Histones; Humans; Metabolic Networks and Pathways; Methylation; Neoplasms; Nutrients; Nutrigenomics; Protein Processing, Post-Translational; Signal Transduction | 2018 |
Epitranscriptomic Code and Its Alterations in Human Disease.
Topics: Cardiovascular Diseases; Congenital Abnormalities; Epigenesis, Genetic; High-Throughput Nucleotide Sequencing; Humans; Metabolic Diseases; Methylation; Mitochondrial Diseases; Neoplasms; Nervous System Diseases; Purine Nucleotides; Pyrimidine Nucleotides; RNA; RNA Processing, Post-Transcriptional; Transcriptome | 2018 |
Aberrant Regulation of mRNA m⁶A Modification in Cancer Development.
Topics: Adenosine; Animals; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; Neoplasms; RNA, Messenger | 2018 |
KDM5B is a master regulator of the H3K4-methylome in stem cells, development and cancer.
Topics: Biomarkers, Tumor; Cell Transformation, Neoplastic; Epigenesis, Genetic; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Neoplasms; Nuclear Proteins; Repressor Proteins; Stem Cells | 2019 |
A dynamic reversible RNA N
Topics: Adenosine; Epigenesis, Genetic; Humans; Lipid Metabolism; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Messenger | 2019 |
tRNA modification and cancer: potential for therapeutic prevention and intervention.
Topics: Animals; Codon; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; Oxidative Stress; RNA, Transfer; tRNA Methyltransferases | 2019 |
RNA 2'-O-Methylation (Nm) Modification in Human Diseases.
Topics: Animals; Autoimmune Diseases; Epigenesis, Genetic; Humans; Methylation; Neoplasms; Nervous System Diseases; RNA; RNA Processing, Post-Transcriptional | 2019 |
The role of m6A RNA methylation in cancer.
Topics: Adenosine; Animals; Humans; Methylation; Neoplasms; RNA | 2019 |
Functions of RNA N6-methyladenosine modification in cancer progression.
Topics: Adenosine; Animals; Disease Progression; Humans; Methylation; Neoplasms; RNA | 2019 |
Posttranslational regulation of PGC-1α and its implication in cancer metabolism.
Topics: Autophagy; Humans; Methylation; Mitochondria; Mitophagy; Neoplasms; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Protein Conformation; Protein Processing, Post-Translational; Signal Transduction | 2019 |
Importance of m N
Topics: Adenosine; Animals; DNA Damage; Humans; Methylation; Neoplasms; RNA, Neoplasm | 2019 |
The Critical Role of RNA m
Topics: Adenosine; Demethylation; Humans; Methylation; Methyltransferases; Neoplasms; RNA; RNA-Binding Proteins | 2019 |
Role of protein arginine methyltransferase 5 in human cancers.
Topics: Animals; Biomarkers, Tumor; Histones; Humans; Methylation; Neoplasms; Protein-Arginine N-Methyltransferases | 2019 |
Functions of RNA N6-methyladenosine modification in cancer progression.
Topics: Adenosine; Disease Progression; Humans; Methylation; Methyltransferases; Neoplasms; RNA; RNA Processing, Post-Transcriptional | 2019 |
Lysine methylation of transcription factors in cancer.
Topics: Antineoplastic Agents; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplasms; Protein Processing, Post-Translational; Protein Stability; Transcription Factors | 2019 |
Detection of N6‑methyladenosine modification residues (Review).
Topics: Adenosine; Animals; Biosensing Techniques; Blotting, Northern; Chromatography, High Pressure Liquid; Electrochemical Techniques; Humans; Immunoblotting; Immunoprecipitation; Methylation; Neoplasms; RNA; Sequence Analysis, RNA | 2019 |
A Review in Research Progress Concerning m6A Methylation and Immunoregulation.
Topics: Active Transport, Cell Nucleus; Adenosine; Humans; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional; RNA Splicing; RNA, Messenger | 2019 |
Understanding histone H3 lysine 36 methylation and its deregulation in disease.
Topics: DNA Modification Methylases; DNA Repair; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Neoplasms; Neurodevelopmental Disorders; RNA Splicing | 2019 |
Epigenetic Modification in Macrophages: A Promising Target for Tumor and Inflammation-associated Disease Therapy.
Topics: Acetylation; Animals; Antineoplastic Agents; DNA Methylation; Epigenesis, Genetic; Histones; Humans; Inflammation; Macrophages; Methylation; Neoplasms | 2019 |
PRMTs and Arginine Methylation: Cancer's Best-Kept Secret?
Topics: Animals; Antineoplastic Agents; Arginine; DNA Damage; Drug Resistance; Epigenomics; Histones; Humans; Immunotherapy; Methylation; Mice; Molecular Targeted Therapy; Neoplasms; Protein Processing, Post-Translational; Protein Splicing; Protein-Arginine N-Methyltransferases; RNA Splicing; Stem Cells | 2019 |
PRMTs and miRNAs: functional cooperation in cancer and beyond.
Topics: 3' Untranslated Regions; Arginine; Cardiovascular Diseases; Epigenesis, Genetic; Histones; Humans; Inflammation; Methylation; MicroRNAs; Neoplasms; Neurodegenerative Diseases; Peptide Chain Initiation, Translational; Protein Binding; Protein-Arginine N-Methyltransferases | 2019 |
The importance of non-histone protein methylation in cancer therapy.
Topics: Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Enzyme Inhibitors; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational | 2019 |
New discoveries of mdig in the epigenetic regulation of cancers.
Topics: Animals; Biomarkers, Tumor; Cell Cycle; Dioxygenases; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genetic Association Studies; Genetic Predisposition to Disease; Histone Demethylases; Histones; Humans; Methylation; Neoplasms; Neoplastic Stem Cells; Nuclear Proteins; Prognosis | 2019 |
The regulation, functions and clinical relevance of arginine methylation.
Topics: Animals; Arginine; Humans; Methylation; Neoplasm Proteins; Neoplasms; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Signal Transduction | 2019 |
Histone methyltransferase SMYD2: ubiquitous regulator of disease.
Topics: Cardiovascular Diseases; Epigenesis, Genetic; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Molecular Targeted Therapy; Neoplasms | 2019 |
Context-specific regulation of cancer epigenomes by histone and transcription factor methylation.
Topics: Chromatin; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational; Transcription Factors | 2014 |
Regulation of chromatin structure via histone post-translational modification and the link to carcinogenesis.
Topics: Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; DNA Repair; Gene Expression Regulation, Neoplastic; Genes, Immediate-Early; Genomic Instability; Histone Demethylases; Histones; Humans; Interphase; Methylation; Mitosis; Neoplasms; Phosphorylation; Prognosis; Protein Processing, Post-Translational; Transcriptome; Ubiquitination | 2013 |
Drugging the human methylome: an emerging modality for reversible control of aberrant gene transcription.
Topics: Amino Acid Sequence; Animals; Drug Discovery; Humans; Methylation; Molecular Sequence Data; Neoplasms; Proteins; Transcription, Genetic | 2013 |
Defining the RGG/RG motif.
Topics: Alternative Splicing; Amino Acid Motifs; Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Apoptosis; Arginine; DNA Damage; Fragile X Syndrome; Humans; Methylation; Molecular Sequence Data; Neoplasms; Neuromuscular Diseases; Protein Biosynthesis; Protein Interaction Domains and Motifs; Proteins | 2013 |
Serine, glycine and one-carbon units: cancer metabolism in full circle.
Topics: Epigenesis, Genetic; Glycine; Humans; Methylation; Neoplasms; Oxidation-Reduction; Serine | 2013 |
Advances in understanding the coupling of DNA base modifying enzymes to processes involving base excision repair.
Topics: 5-Methylcytosine; Animals; Cell Differentiation; DNA; DNA Damage; DNA Glycosylases; DNA Methylation; DNA Repair; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms; Purines; Pyrimidines | 2013 |
Decoding the histone code: Role of H3K36me3 in mismatch repair and implications for cancer susceptibility and therapy.
Topics: Base Pair Mismatch; Histone Code; Humans; Lysine; Methylation; Neoplasms; Polycomb Repressive Complex 2 | 2013 |
The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression.
Topics: Animals; Cell Cycle; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; Drosophila melanogaster; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histones; Humans; Isoenzymes; Methylation; Mice; Mice, Transgenic; Neoplasms; Signal Transduction | 2013 |
Mutant TP53 posttranslational modifications: challenges and opportunities.
Topics: Acetylation; Gene Expression Regulation, Neoplastic; Humans; Methylation; Mutation; Neoplasms; Phosphorylation; Signal Transduction; Tumor Suppressor Protein p53; Ubiquitination | 2014 |
The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle.
Topics: Animals; Cell Cycle; Cellular Reprogramming; Chromatin; DNA Damage; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms | 2014 |
Chromatin dynamics: H3K4 methylation and H3 variant replacement during development and in cancer.
Topics: Amino Acid Sequence; Chromatin; Chromatin Assembly and Disassembly; Epigenomics; Gene Expression Regulation; Genetic Variation; Genome; Histones; Humans; Methylation; Models, Genetic; Molecular Sequence Data; Neoplasms; Sequence Alignment | 2014 |
Examining the impact of gene variants on histone lysine methylation.
Topics: Animals; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mutation; Neoplasms; Polymorphism, Single Nucleotide | 2014 |
Mechanism and function of oxidative reversal of DNA and RNA methylation.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; Escherichia coli; Gene Expression Regulation; Genome; Germ Cells; HEK293 Cells; Humans; Methylation; Mice; Neoplasms; Oxygen; RNA; Stem Cells; Transcriptome | 2014 |
The deep end of the metabolite pool: influences on epigenetic regulatory mechanisms in cancer.
Topics: Acetylation; Acetylglucosamine; Citric Acid Cycle; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glycosylation; Histones; Humans; Methylation; Neoplasms; S-Adenosylmethionine; Uridine Diphosphate | 2015 |
Targeting histone lysine methylation in cancer.
Topics: Animals; Antineoplastic Agents; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Molecular Targeted Therapy; Neoplasms; Signal Transduction | 2015 |
The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond.
Topics: Adaptor Proteins, Signal Transducing; Arginine; Catalytic Domain; Cell Differentiation; Gene Expression Regulation; Histones; Humans; Methylation; Multiprotein Complexes; Neoplasms; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Quaternary; Protein-Arginine N-Methyltransferases | 2015 |
Fibrillarin from Archaea to human.
Topics: Animals; Archaea; Chromosomal Proteins, Non-Histone; Humans; Methylation; Neoplasms | 2015 |
Epigenetic regulation by histone demethylases in hypoxia.
Topics: Cardiovascular Diseases; Epigenesis, Genetic; Histones; Humans; Hypoxia; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Models, Genetic; Neoplasms | 2015 |
The NSD family of protein methyltransferases in human cancer.
Topics: Antineoplastic Agents; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Methylation; Molecular Targeted Therapy; Mutation; Neoplasms; Nuclear Proteins; Repressor Proteins | 2015 |
[Development of novel epigenetic molecular-targeting agents].
Topics: Acetylation; Antineoplastic Agents; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA, Neoplasm; Drug Discovery; Enzyme Inhibitors; Epigenesis, Genetic; Fusion Proteins, bcr-abl; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone Demethylases; Histones; Humans; Methylation; Molecular Targeted Therapy; Mutation; Neoplasms; Oncogenes; Protein Kinase Inhibitors | 2015 |
PRC2 mediated H3K27 methylations in cellular identity and cancer.
Topics: Animals; Cell Differentiation; Cell Lineage; Histones; Humans; Methylation; Neoplasms; Polycomb Repressive Complex 2 | 2015 |
Posttranscriptional methylation of transfer and ribosomal RNA in stress response pathways, cell differentiation, and cancer.
Topics: Cell Differentiation; Cytidine; Cytosine; Humans; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Ribosomal; Stress, Physiological | 2016 |
N6-methyladenosine modification in mRNA: machinery, function and implications for health and diseases.
Topics: Adenosine; Cell Differentiation; Eukaryotic Cells; Humans; Methylation; Methyltransferases; Neoplasms; Neurodegenerative Diseases; Oxidoreductases, N-Demethylating; RNA Splicing; RNA, Long Noncoding; RNA, Messenger; Signal Transduction; Transcription, Genetic | 2016 |
Dysregulation of protein methyltransferases in human cancer: An emerging target class for anticancer therapy.
Topics: Antineoplastic Agents; Epigenesis, Genetic; Histones; Humans; Methylation; Molecular Targeted Therapy; Neoplasms; Protein Methyltransferases; Protein Processing, Post-Translational | 2016 |
Enhancement of anticancer potential of polyphenols by covalent modifications.
Topics: Acetylation; Acylation; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Hydroxylation; Methylation; Neoplasm Proteins; Neoplasms; Neovascularization, Pathologic; Polyphenols; Structure-Activity Relationship | 2016 |
Small Molecular Inhibitors Targeting Chromatin Regulating Proteins for Cancer.
Topics: Acetylation; Animals; Antineoplastic Agents; Chromatin; Chromatin Assembly and Disassembly; Drug Discovery; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Methylation; Molecular Targeted Therapy; Neoplasms; Nuclear Proteins; Nucleoproteins | 2016 |
Histone Modifications and Cancer.
Topics: Acetylation; Chromatin Assembly and Disassembly; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Code; Histones; Methylation; Neoplasms | 2016 |
Give it or take it: the flux of one-carbon in cancer cells.
Topics: Animals; Carbon; Carbon Cycle; Cell Compartmentation; Cytosol; Embryonic Development; Glycine; Humans; Metabolic Networks and Pathways; Methylation; Mitochondria; Models, Biological; Neoplasms; Serine | 2016 |
TCPs: privileged scaffolds for identifying potent LSD1 inhibitors for cancer therapy.
Topics: Animals; Antineoplastic Agents; Drug Design; Gene Expression Regulation, Neoplastic; Histone Demethylases; Humans; Methylation; Molecular Targeted Therapy; Neoplasms; Protein Processing, Post-Translational; Structure-Activity Relationship; Tranylcypromine | 2016 |
Epigenetic balance of gene expression by Polycomb and COMPASS families.
Topics: Animals; Chromatin; Chromosomal Proteins, Non-Histone; Drosophila melanogaster; Embryonic Development; Enhancer Elements, Genetic; Epigenesis, Genetic; Gene Expression; Growth and Development; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Mutation; Neoplasms; Polycomb-Group Proteins; Saccharomyces cerevisiae | 2016 |
Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.
Topics: Animals; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Models, Molecular; Mutation; Neoplasms; Nucleic Acid Conformation; Oncogenes; Phosphorylation; Protein Binding; Protein Conformation; Structure-Activity Relationship; Transcription, Genetic | 2016 |
Histone demethylase LSD1 controls the phenotypic plasticity of cancer cells.
Topics: Animals; Cell Transformation, Neoplastic; Energy Metabolism; Epigenesis, Genetic; Gene Expression Regulation, Leukemic; Histone Demethylases; Histones; Humans; Methylation; Neoplasms; Phenotype | 2016 |
Writers and Erasers of Histone Lysine methylation with Clinically Applied Modulators: Promising Target for Cancer Therapy.
Topics: Antineoplastic Agents; Histones; Humans; Lysine; Methylation; Neoplasms | 2016 |
[Methionine metabolism regulates biotransformation of glucose via protein arginine methylation in cancer cells].
Topics: Animals; Arginine; Glucose; Humans; Methionine; Methylation; Neoplasms; Proteins | 2016 |
Protein arginine methylation/demethylation and cancer.
Topics: Arginine; Demethylation; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Neoplasms; Protein Processing, Post-Translational | 2016 |
Nonhistone Lysine Methylation in the Regulation of Cancer Pathways.
Topics: Cell Transformation, Neoplastic; Chromosomal Proteins, Non-Histone; DNA Damage; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Neoplasms; Protein Processing, Post-Translational; Signal Transduction | 2016 |
Folylpoly-γ-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Homeostasis; Humans; Methylation; Mice; Neoplasms; Peptide Synthases; Polyglutamic Acid; S-Adenosylmethionine; Signal Transduction | 2016 |
Cancer metabolism at a glance.
Topics: Animals; Fatty Acids; Humans; Metabolic Networks and Pathways; Metabolome; Methylation; Neoplasms; Reactive Oxygen Species | 2016 |
MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer.
Topics: Animals; Cell Transformation, Neoplastic; DNA-Binding Proteins; Enhancer Elements, Genetic; Epigenesis, Genetic; Gene Expression; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Mice; Neoplasms; Protein Processing, Post-Translational | 2016 |
Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1.
Topics: Animals; Carboxylic Ester Hydrolases; Humans; Methylation; Models, Biological; Neoplasms; Phosphorylation; Protein Phosphatase 2; Signal Transduction; Tumor Suppressor Proteins | 2016 |
The story of protein arginine methylation: characterization, regulation, and function.
Topics: Arginine; Cardiovascular Diseases; DNA Repair; Humans; Mass Spectrometry; Methylation; Multiple Sclerosis; Muscular Atrophy, Spinal; Neoplasms; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Proteins; Proteomics; Signal Transduction | 2017 |
Histone Lysine Demethylase Inhibitors.
Topics: Animals; Enzyme Inhibitors; Histone Demethylases; Histones; Humans; Methylation; Mice; Neoplasms; Structure-Activity Relationship | 2017 |
Epigenetics in cancer stem cells.
Topics: Acetylation; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Epigenomics; Histones; Humans; Methylation; Neoplasm Metastasis; Neoplasms; Neoplastic Stem Cells; Signal Transduction | 2017 |
Clinical and biological effects of demethylating agents on solid tumours - A systematic review.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cytidine; Decitabine; DNA Methylation; Humans; Hydralazine; Immune System; Methylation; Neoplasms; Procaine; Treatment Outcome | 2017 |
[Role of Histone Methylation in Myeloid Malignancies -Review].
Topics: Epigenesis, Genetic; Histones; Methylation; Neoplasms | 2017 |
Regulatory Role of N
Topics: Adenosine; Animals; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Humans; Methylation; Neoplasms; Obesity; RNA Processing, Post-Transcriptional; RNA, Neoplasm | 2017 |
Epigenetic Control of Autophagy: Nuclear Events Gain More Attention.
Topics: Acetylation; Animals; Autophagy; Cell Nucleus; Chromatin; Chromatin Assembly and Disassembly; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms; Protein Methyltransferases | 2017 |
A saga of cancer epigenetics: linking epigenetics to alternative splicing.
Topics: Acetylation; Alternative Splicing; Disease Progression; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Neoplasms; RNA Polymerase II; RNA-Binding Proteins; Transcription Elongation, Genetic | 2017 |
High mobility group proteins and their post-translational modifications.
Topics: Acetylation; Active Transport, Cell Nucleus; Amino Acid Sequence; Animals; High Mobility Group Proteins; Histones; Humans; Methylation; Models, Molecular; Molecular Sequence Data; Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Protein Structure, Tertiary | 2008 |
Can folate intake reduce arsenic toxicity?
Topics: Arsenic; Arsenic Poisoning; Environmental Exposure; Folic Acid; Humans; Methylation; Neoplasms; Risk Factors; Vitamin B Complex | 2008 |
Protein arginine methylation in health and disease.
Topics: Animals; Arginine; Autoimmune Diseases; Cardiovascular Diseases; Humans; Methylation; Models, Biological; Neoplasms; Virus Diseases | 2008 |
Transcription-independent functions of MYC: regulation of translation and DNA replication.
Topics: Animals; DNA Replication; Genes, myc; Humans; Methylation; Models, Biological; Models, Genetic; Neoplasms; Protein Biosynthesis; Proto-Oncogene Proteins c-myc; RNA Caps; RNA, Messenger; Transcription Factors | 2008 |
Dynamic protein methylation in chromatin biology.
Topics: Animals; Arginine; Chromatin; DNA Damage; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Regulation; Germ Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Models, Molecular; Molecular Structure; Neoplasms; Oxidoreductases, N-Demethylating; Protein Conformation; Protein Methyltransferases; Protein Processing, Post-Translational; Tumor Suppressor Protein p53 | 2009 |
The critical role of the class III histone deacetylase SIRT1 in cancer.
Topics: Acetylation; Animals; Apoptosis; Cell Proliferation; CpG Islands; DNA Methylation; Enzyme Inhibitors; Genes, Tumor Suppressor; Histones; Humans; Methylation; Neoplasms; Oncogenes; RNA, Messenger; Sirtuin 1; Sirtuins | 2009 |
[Histone modification: a new era of targeting epigenetics].
Topics: Acetylation; Animals; Chromatin; DNA; Drug Discovery; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms; Phosphorylation | 2009 |
The physiological and pathophysiological role of PRMT1-mediated protein arginine methylation.
Topics: Animals; DNA Methylation; Heart Diseases; Humans; Kidney Diseases; Methylation; Neoplasms; Protein-Arginine N-Methyltransferases; Repressor Proteins | 2009 |
The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors.
Topics: Arginine; Enzyme Inhibitors; Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplasms; Protein Processing, Post-Translational | 2009 |
Towards targeted epigenetic therapy of cancer.
Topics: Acetylation; DNA Modification Methylases; Epigenesis, Genetic; Genetic Therapy; Histones; Humans; Methylation; MicroRNAs; Mutation; Neoplasms; Pharmacogenetics | 2009 |
Protein arginine methylation in estrogen signaling and estrogen-related cancers.
Topics: Animals; Arginine; Breast Neoplasms; Estrogens; Female; Humans; Male; Methylation; Models, Biological; Neoplasms; Protein-Arginine N-Methyltransferases; Receptors, Estrogen; Signal Transduction | 2010 |
[Current situation researching of methylation in tumor].
Topics: DNA Methylation; Histones; Humans; Methylation; Neoplasms | 2009 |
Methylation of dietary flavones increases their metabolic stability and chemopreventive effects.
Topics: Animals; Cell Membrane Permeability; Diet; Flavones; Half-Life; Humans; Methylation; Microsomes, Liver; Neoplasms | 2009 |
Viral epigenomes in human tumorigenesis.
Topics: CpG Islands; DNA Methylation; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms; Viral Proteins; Virus Diseases; Viruses | 2010 |
Epigenetic changes in the myelodysplastic syndrome.
Topics: Acetylation; Acute Disease; Azacitidine; Cell Transformation, Neoplastic; Decitabine; DNA Methylation; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Leukemia, Myeloid; Methylation; Myelodysplastic Syndromes; Neoplasms; Protein Processing, Post-Translational | 2010 |
Epigenetic alterations in aging.
Topics: Acetylation; Age Factors; Aging; Aging, Premature; Animals; Chromatin Assembly and Disassembly; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Neoplasms; RNA, Untranslated | 2010 |
Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers.
Topics: Animals; Histones; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational | 2010 |
Cancer in experimental animals exposed to arsenic and arsenic compounds.
Topics: Animals; Arsenic; Arsenicals; Carcinogens; Disease Models, Animal; Female; Humans; Male; Methylation; Mice; Mice, Inbred Strains; Neoplasms; Rats; Rats, Inbred Strains | 2010 |
[Disease and epigenome analysis].
Topics: Acetylation; Animals; Cell Transformation, Neoplastic; Chromatin; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genomics; Histones; Humans; Life Style; Mental Disorders; Methylation; Neoplasms; Neoplastic Stem Cells | 2010 |
Organoarsenicals. Uptake, metabolism, and toxicity.
Topics: Animals; Arsenicals; Carcinogens; DNA Damage; Environmental Exposure; Humans; Methylation; Neoplasms; Organometallic Compounds; Water Pollutants, Chemical | 2010 |
Inheritance of epigenetic aberrations (constitutional epimutations) in cancer susceptibility.
Topics: Adaptor Proteins, Signal Transducing; Agouti Signaling Protein; alpha-Thalassemia; Animals; Biomarkers, Tumor; Colorectal Neoplasms, Hereditary Nonpolyposis; DNA Mismatch Repair; Epigenesis, Genetic; Female; Gene Silencing; Genes, Tumor Suppressor; Genetic Predisposition to Disease; Humans; Linaria; Male; Methylation; Mice; MicroRNAs; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasms; Nuclear Proteins; Polymorphism, Single Nucleotide | 2010 |
Histone modification therapy of cancer.
Topics: Acetylation; Animals; Antineoplastic Agents; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Methylation; Methyltransferases; Neoplasms; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases | 2010 |
p53 post-translational modification: deregulated in tumorigenesis.
Topics: Acetylation; Animals; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Tumor Suppressor Protein p53; Ubiquitination | 2010 |
Errors in erasure: links between histone lysine methylation removal and disease.
Topics: Animals; Cathepsin L; Cell Cycle Proteins; Histone Chaperones; Histone Demethylases; Histones; Humans; Lysine; Methylation; Neoplasms; Transcription Factors | 2011 |
Epigenetic cancer therapy: Proof of concept and remaining challenges.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Molecular Targeted Therapy; Neoplasms | 2010 |
The Polycomb complex PRC2 and its mark in life.
Topics: Animals; Cell Differentiation; Chromatin; Evolution, Molecular; Genome; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Neoplasms; Polycomb-Group Proteins; Repressor Proteins | 2011 |
Histone onco-modifications.
Topics: Acetylation; Cell Transformation, Neoplastic; Chromatin; DNA Repair; Epigenesis, Genetic; Gene Silencing; Histones; Humans; Methylation; Neoplasms; Oncogene Proteins; Protein Processing, Post-Translational | 2011 |
Epigenetics, development, and cancer: zebrafish make their mark..
Topics: Acetylation; Animals; DNA Methylation; Embryonic Development; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Histones; Liver; Methylation; Models, Animal; Neoplasms; Zebrafish | 2011 |
PRDM proteins: important players in differentiation and disease.
Topics: Adipose Tissue, Brown; Animals; Blood Vessels; Cell Differentiation; Gene Expression Regulation; Hematologic Neoplasms; Hematopoiesis; Histones; Humans; Isoenzymes; Methylation; Mice; Mice, Transgenic; Neoplasms; Organ Specificity; Protein Methyltransferases; Signal Transduction; Transcription, Genetic; Tumor Suppressor Proteins | 2012 |
Alterations in histone H4 lysine 20 methylation: implications for cancer detection and prevention.
Topics: Animals; Epigenesis, Genetic; Epigenomics; Histones; Humans; Lysine; Methylation; Neoplasms | 2012 |
Carbon monoxide: impact on remethylation/transsulfuration metabolism and its pathophysiologic implications.
Topics: Carbon Monoxide; Cystathionine beta-Synthase; Heme Oxygenase (Decyclizing); Humans; Hydrogen Sulfide; Methylation; Myocardial Ischemia; Neoplasms; Sulfur | 2012 |
Histone methylation: a dynamic mark in health, disease and inheritance.
Topics: Animals; Caenorhabditis; Drosophila; Epigenesis, Genetic; Female; Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Male; Methylation; Mice; Neoplasms; Protein Processing, Post-Translational; Rats | 2012 |
Molecular mechanisms and potential functions of histone demethylases.
Topics: Animals; Chromatin; Gene Expression Regulation; Histone Demethylases; Histones; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational; Protein Structure, Tertiary; Substrate Specificity | 2012 |
Mechanistic links between ATM and histone methylation codes during DNA repair.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; DNA Repair; DNA-Binding Proteins; Histone Code; Histones; Humans; Methylation; Neoplasms; Protein Serine-Threonine Kinases; Tumor Suppressor Proteins | 2012 |
Oncoepigenomics: making histone lysine methylation count.
Topics: Animals; Epigenomics; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplasms | 2012 |
Redox regulation of the epigenetic landscape in cancer: a role for metabolic reprogramming in remodeling the epigenome.
Topics: Acetylation; Animals; Carbohydrate Metabolism; Epigenesis, Genetic; Epigenomics; Genome, Human; Histones; Humans; Methylation; Neoplasms; Oxidation-Reduction; Protein Processing, Post-Translational | 2012 |
Tipping the lysine methylation balance in disease.
Topics: Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Mutation; Neoplasms; Nervous System Diseases | 2013 |
The methylation landscape of tumour metastasis.
Topics: Animals; DNA Methylation; Epigenomics; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Neoplasm Metastasis; Neoplasms | 2013 |
Histone methyltransferases, diet nutrients and tumour suppressors.
Topics: Amino Acid Sequence; Diet; Folic Acid Deficiency; Forecasting; Genes, Tumor Suppressor; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Methionine; Methylation; Methyltransferases; Molecular Sequence Data; Neoplasms; Protein Methyltransferases; Sequence Homology, Amino Acid | 2002 |
Senescence and epigenetic dysregulation in cancer.
Topics: Animals; Cell Cycle; Cellular Senescence; DNA; Genes, Tumor Suppressor; Histone Deacetylases; Histones; Humans; Methylation; Neoplasms; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Telomerase; Telomere | 2002 |
Methods for the molecular analysis of cancer. An overview.
Topics: Animals; DNA Mutational Analysis; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization, Fluorescence; Methylation; Mutation; Neoplasms; Oligonucleotide Array Sequence Analysis; Sequence Analysis, DNA; Sequence Analysis, RNA; Telomerase | 2003 |
News and views on folate and elderly persons.
Topics: Aged; Cardiovascular Diseases; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Mental Disorders; Methylation; Neoplasms; Risk Factors; Vitamin B 12 Deficiency | 2003 |
Folate and cancer: a review of the literature.
Topics: Animals; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Humans; Methylation; Neoplasms; Risk Factors | 1994 |
Drug methylation in cancer therapy: lessons from the TPMT polymorphism.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Evolution, Molecular; Humans; Methylation; Methyltransferases; Molecular Sequence Data; Neoplasms; Pharmacogenetics; Polymorphism, Genetic | 2003 |
Folate, methyl-related nutrients, alcohol, and the MTHFR 677C-->T polymorphism affect cancer risk: intake recommendations.
Topics: Adenoma; Alcohol Drinking; Colonic Neoplasms; Folic Acid; Humans; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mutation, Missense; Neoplasms; Nutrition Policy; Polymorphism, Single Nucleotide; Risk Factors; Vitamin B 12 | 2003 |
Histone modification enzymes: novel targets for cancer drugs.
Topics: Acetylation; Acetyltransferases; Antineoplastic Agents; Chromatin; Clinical Trials as Topic; Drug Design; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Acetyltransferases; Histone Deacetylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Methylation; Multicenter Studies as Topic; Neoplasm Proteins; Neoplasms; Phosphorylation; Protamine Kinase; Protein Methyltransferases; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Tyrosine Phosphatases | 2004 |
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.
Topics: Acetylation; Amino Acid Sequence; Apoptosis; Cell Transformation, Neoplastic; Chromatin; High Mobility Group Proteins; Methylation; Molecular Sequence Data; Neoplasms; Protein Conformation; Sequence Homology, Amino Acid | 2004 |
Histone modifications as a platform for cancer therapy.
Topics: Chromatin; DNA Methylation; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histones; Humans; Methylation; Mitogen-Activated Protein Kinases; Neoplasms; Phosphorylation; Signal Transduction | 2005 |
PTHrP gene expression in cancer: do all paths lead to Ets?
Topics: Base Sequence; Bone Neoplasms; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Methylation; Mitogen-Activated Protein Kinase Kinases; Neoplasms; Parathyroid Hormone-Related Protein; Promoter Regions, Genetic; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Transcription Factors; Transforming Growth Factor beta; Vitamin D | 2005 |
Linking covalent histone modifications to epigenetics: the rigidity and plasticity of the marks.
Topics: Amidohydrolases; Amino Acid Sequence; Animals; Cell Differentiation; Chromatin; Cloning, Organism; Embryonic Development; Epigenesis, Genetic; Female; Germ Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Hydrolases; Methylation; Mice; Models, Genetic; Molecular Sequence Data; Neoplasms; Pregnancy; Protein Methyltransferases; Protein-Arginine Deiminases | 2004 |
Towards the human cancer epigenome: a first draft of histone modifications.
Topics: Acetylation; Animals; Chromatin; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms | 2005 |
Chromatin modifier enzymes, the histone code and cancer.
Topics: Acetylation; Chromatin; DNA Damage; DNA Methylation; Histone Code; Histones; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational; RNA Interference | 2005 |
New therapeutic targets in cancer: the epigenetic connection.
Topics: Acetylation; Amino Acid Sequence; Antineoplastic Agents; Clinical Trials as Topic; Disease Progression; DNA Methylation; DNA, Neoplasm; Drug Design; Epigenesis, Genetic; Forecasting; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Methylation; Models, Molecular; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Protein Conformation; Protein Processing, Post-Translational | 2006 |
[E-cadherin cell adhesion system in human cancer].
Topics: Actinin; Cadherins; Catenins; Cell Adhesion; Cell Adhesion Molecules; Delta Catenin; Gene Expression Regulation, Neoplastic; Humans; Methylation; Microfilament Proteins; Mutation; Neoplasm Invasiveness; Neoplasms; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Signal Transduction | 2006 |
DNA methylation and histone modifications in patients with cancer: potential prognostic and therapeutic targets.
Topics: Acetylation; Antineoplastic Agents; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Neoplasms; Prognosis; Protein Processing, Post-Translational; Tumor Suppressor Proteins | 2007 |
The 3D structure of protein phosphatase 2A: new insights into a ubiquitous regulator of cell signaling.
Topics: Amino Acid Substitution; Crystallography, X-Ray; Holoenzymes; Humans; Methylation; Neoplasms; Noxae; Phosphoprotein Phosphatases; Protein Conformation; Protein Phosphatase 2; Protein Subunits; Signal Transduction | 2007 |
The role of RASSF1A methylation in cancer.
Topics: Animals; Biomarkers, Tumor; Humans; Methylation; Neoplasms; Tumor Suppressor Proteins | 2007 |
Histone acetylation and methylation: combinatorial players for transcriptional regulation.
Topics: Acetylation; Amino Acid Sequence; Animals; Chromatin; Chromatin Assembly and Disassembly; Histone Acetyltransferases; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Molecular Sequence Data; Neoplasms; Protein Processing, Post-Translational; Transcription, Genetic | 2007 |
Small molecule modulators in epigenetics: implications in gene expression and therapeutics.
Topics: Acetylation; Animals; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Carriers; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Neoplasms; Phosphorylation; Protamine Kinase; Protein Processing, Post-Translational; Rubinstein-Taybi Syndrome | 2007 |
The function and regulation of the JARID1 family of histone H3 lysine 4 demethylases: the Myc connection.
Topics: Animals; Caenorhabditis elegans Proteins; Cell Transformation, Neoplastic; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Epigenesis, Genetic; Gene Expression Regulation; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Jumonji Domain-Containing Histone Demethylases; Lysine; Mammals; Methylation; Mice; Mice, Knockout; Neoplasms; Nuclear Proteins; Nucleosomes; Oxidoreductases, N-Demethylating; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proto-Oncogene Proteins c-myc; Repressor Proteins; Retinoblastoma-Binding Protein 2; Saccharomyces cerevisiae Proteins; Substrate Specificity; Tumor Suppressor Proteins | 2007 |
Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?
Topics: Animals; Anticarcinogenic Agents; Cell Transformation, Neoplastic; Chemoprevention; Flavones; Flavonoids; Humans; Methylation; Neoplasms | 2007 |
Interplay between chromatin remodelers and protein arginine methyltransferases.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Arginine; Chromatin; Chromosomal Proteins, Non-Histone; DNA Repair; Gene Expression Regulation; Histones; Humans; Isoenzymes; Methylation; Neoplasms; Protein-Arginine N-Methyltransferases; Transcription Factors; Transcription, Genetic | 2007 |
A role for epigenetics in hearing: Establishment and maintenance of auditory specific gene expression patterns.
Topics: Acetylation; Animals; DNA Methylation; Embryonic Development; Epigenesis, Genetic; Gene Expression; Hearing; Hearing Loss; Histones; Humans; Methylation; Neoplasms | 2007 |
Histone lysine demethylases: emerging roles in development, physiology and disease.
Topics: Amino Acid Sequence; Animals; Gene Expression Regulation, Developmental; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Neoplasms; Nervous System Diseases | 2007 |
[Research progress on the relationship between nutrition and cancer epigenetics---histone modification mechanisms].
Topics: Acetylation; Biotinylation; DNA, Neoplasm; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Neoplasms; Nutritional Physiological Phenomena; Phosphorylation; Poly Adenosine Diphosphate Ribose | 2007 |
Alternative lengthening of telomeres (ALT) and chromatin: is there a connection?
Topics: Animals; Chromatin; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms; Recombination, Genetic; Sister Chromatid Exchange; Telomerase; Telomere | 2008 |
RNA base damage and repair.
Topics: AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase; Animals; Dioxygenases; DNA Damage; DNA Repair; DNA Repair Enzymes; Escherichia coli Proteins; Humans; Methylation; Mixed Function Oxygenases; Neoplasms; Neurodegenerative Diseases; RNA; RNA Stability | 2007 |
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.
Topics: Aging; Animals; Cell Differentiation; Histones; Humans; Methylation; Models, Biological; Neoplasms; Oxidoreductases, N-Demethylating; Phylogeny | 2008 |
Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis. A review and synthesis.
Topics: Adenosine; Animals; Azacitidine; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Choline; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA, Viral; Ethionine; Gene Expression Regulation; Homocysteine; Humans; Methionine; Methylation; Methyltransferases; Neoplasms; Oncogenes; Oncogenic Viruses; S-Adenosylhomocysteine; S-Adenosylmethionine; Simian virus 40 | 1984 |
Possible epigenetic mechanisms of tumor progression: induction of high-frequency heritable but phenotypically unstable changes in the tumorigenic and metastatic properties of tumor cell populations by 5-azacytidine treatment.
Topics: Animals; Azacitidine; DNA; Ethyl Methanesulfonate; Humans; Mammary Neoplasms, Experimental; Methylation; Methylnitronitrosoguanidine; Models, Genetic; Mutation; Neoplasm Metastasis; Neoplasms; Neoplastic Stem Cells; Phenotype; Stem Cells | 1984 |
5-Methylcytosine depletion during tumour development: an extension of the miscoding concept.
Topics: 5-Methylcytosine; Alkylation; Amino Acid Metabolism, Inborn Errors; Animals; Carcinogens; Cell Transformation, Neoplastic; Choline Deficiency; Cytosine; DNA; DNA Repair; Gene Expression Regulation; Humans; Methylation; Methyltransferases; Models, Genetic; Neoplasms; Oncogenes; Rats; Tyrosine; Vitamin B 6 Deficiency | 1983 |
Generation of phenotypic diversity and progression in metastatic tumor cells.
Topics: Animals; Cell Transformation, Neoplastic; Chromosome Aberrations; Clone Cells; DNA; Humans; Methylation; Mutation; Neoplasm Metastasis; Neoplasms; Phenotype | 1984 |
On a possible epigenetic mechanism(s) of tumor cell heterogeneity. The role of DNA methylation.
Topics: Animals; Base Sequence; DNA; DNA, Neoplasm; Genes; Genetic Variation; Humans; Methylation; Models, Biological; Mutagens; Mutation; Neoplasms; Phenotype | 1983 |
DNA methylation patterns. Formation and function.
Topics: Adenine Phosphoribosyltransferase; Animals; Cell Differentiation; DNA; DNA (Cytosine-5-)-Methyltransferases; Eukaryotic Cells; Genes; Growth Hormone; Humans; Insulin; Methylation; Methyltransferases; Neoplasms; Ovalbumin; Species Specificity; Vitellogenins | 1984 |
Structure-activity relationships in the carcinogenicity of anticancer agents.
Topics: Alkylating Agents; Antimetabolites; Antineoplastic Agents; Aziridines; DNA; Hormones; Humans; Methylation; Mitosis; Neoplasms; Nitrogen Mustard Compounds; Structure-Activity Relationship | 1984 |
[Methylation of nucleic acids and its relation to carcinogenesis (author's transl)].
Topics: Biochemical Phenomena; Biochemistry; Humans; Methylation; Neoplasms; Nucleic Acids; RNA, Ribosomal; tRNA Methyltransferases | 1980 |
Parental genomic imprinting.
Topics: Angelman Syndrome; Animals; Beckwith-Wiedemann Syndrome; Diabetes Mellitus, Type 1; Genomic Imprinting; Humans; Insulin-Like Growth Factor II; Kidney Neoplasms; Methylation; Mice; Muscle Proteins; Neoplasms; Prader-Willi Syndrome; RNA, Long Noncoding; RNA, Untranslated; Transcription, Genetic; Wilms Tumor | 1995 |
Lipotrope deficiency and persistent changes in DNA methylation. Lipotrope deficiency and DNA methylation.
Topics: Animals; Choline Deficiency; DNA; Folic Acid Deficiency; Humans; Lipid Metabolism; Liver; Methionine; Methylation; Neoplasms; Vitamin B 12 Deficiency | 1995 |
DNA methylation and mutation.
Topics: 5-Methylcytosine; Animals; Base Composition; Cytosine; Dinucleoside Phosphates; DNA; DNA Repair; Humans; Methylation; Mutation; Neoplasms | 1993 |
[Activation of imprinted genes in human carcinogenesis].
Topics: Animals; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Genomic Imprinting; Humans; Insulin-Like Growth Factor II; Methylation; Neoplasms; Oncogenes | 1995 |
The insertion of foreign DNA into mammalian genomes and its consequences: a concept in oncogenesis.
Topics: Adenoviridae; Animals; DNA; DNA, Viral; Gene Expression Regulation; Genetic Therapy; Humans; Methylation; Neoplasms; Promoter Regions, Genetic; Recombination, Genetic; Virus Integration | 1995 |
DNA damage tolerance, mismatch repair and genome instability.
Topics: Animals; Bacterial Proteins; Base Sequence; CHO Cells; Colonic Neoplasms; Cricetinae; DNA Damage; DNA Repair; DNA, Satellite; Escherichia coli; Female; Fungal Proteins; Genome; Guanine; Humans; Male; Mammals; Methylation; Methyltransferases; Molecular Sequence Data; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Saccharomyces cerevisiae; Sister Chromatid Exchange | 1994 |
DNA methylation and cancer.
Topics: Animals; Cell Transformation, Neoplastic; DNA Modification Methylases; DNA, Neoplasm; Gene Expression; Humans; Methylation; Mutation; Neoplasms | 1994 |
Methyl donors in the diet and responses to chemical carcinogens.
Topics: Animals; Carcinogens; Choline Deficiency; Diet; Folic Acid Deficiency; Humans; Liver Neoplasms, Experimental; Methionine; Methylation; Neoplasms | 1995 |
Hypomethylation of DNA: an epigenetic mechanism involved in tumor promotion.
Topics: Animals; DNA; DNA, Neoplasm; Gene Expression; Methylation; Mice; Neoplasms; Neoplasms, Experimental; Oncogenes | 1994 |
Genomic imprinting, DNA methylation, and cancer.
Topics: Animals; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms | 1994 |
Mechanisms of carcinogenicity of methyl halides.
Topics: Animals; DNA; Humans; Hydrocarbons, Brominated; Hydrocarbons, Iodinated; Methyl Chloride; Methylation; Mutagenicity Tests; Neoplasms | 1993 |
Gene imprinting during placental and embryonic development.
Topics: Alleles; Animals; Biological Evolution; Dosage Compensation, Genetic; Embryonic and Fetal Development; Gene Expression Regulation; Humans; Methylation; Neoplasms; Placentation | 1993 |
Epigenetic inheritance based on DNA methylation.
Topics: Aging; Animals; Base Sequence; Cell Line; DNA; Fragile X Syndrome; Genetic Diseases, Inborn; Humans; Mammals; Methylation; Neoplasms; Repetitive Sequences, Nucleic Acid; Sex Chromosome Aberrations; X Chromosome; Zea mays | 1993 |
DNA methylation and cancer.
Topics: 5-Methylcytosine; Animals; Cytosine; Dinucleoside Phosphates; DNA; DNA Repair; Genes, p53; Genes, Tumor Suppressor; Humans; Methylation; Mutagens; Mutation; Neoplasms; Transcription, Genetic | 1993 |
Cancer. Exploring the bowels of DNA methylation.
Topics: Animals; DNA; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Humans; Methylation; Mice; Neoplasms; Proto-Oncogenes | 1995 |
Genomic imprinting, DNA methylation, and cancer.
Topics: Animals; Beckwith-Wiedemann Syndrome; DNA, Neoplasm; Genomic Imprinting; Humans; Methylation; Models, Genetic; Neoplasms; Neoplasms, Experimental; Pedigree | 1995 |
[Folate deficiency, cancer and congenital abnormalities. Is there a connection?].
Topics: Adult; Congenital Abnormalities; DNA; Female; Folic Acid; Folic Acid Deficiency; Hematinics; Humans; Methylation; Neoplasms; Pregnancy | 1996 |
A possible role in chemical carcinogenesis for epigenetic, heritable changes in gene expression.
Topics: Animals; Carcinogens; Chromatin; DNA-Binding Proteins; Gene Expression; Genes, Regulator; Helix-Loop-Helix Motifs; Methylation; Models, Biological; Neoplasms; Repressor Proteins; Transcription Factors | 1996 |
DNA methylation and polyamines in embryonic development and cancer.
Topics: 5-Methylcytosine; Animals; Cell Transformation, Neoplastic; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Replication; Embryonic and Fetal Development; Female; Gene Expression Regulation, Developmental; Humans; Male; Methylation; Mice; Mutagenesis; Neoplasms; Nucleic Acid Conformation; Oogenesis; Polyamines; Replication Origin; Spermatogenesis; Transcription, Genetic | 1995 |
DNA methylation errors and cancer.
Topics: 5-Methylcytosine; Animals; Cytosine; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Imprinting, Psychological; Methylation; Mutation; Neoplasms | 1996 |
DNA-replication fidelity, mismatch repair and genome instability in cancer cells.
Topics: Base Sequence; Colorectal Neoplasms, Hereditary Nonpolyposis; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Escherichia coli; Genetic Predisposition to Disease; Humans; Methylation; Microsatellite Repeats; Molecular Sequence Data; Mutation; Neoplasms | 1996 |
[Molecular cancer epidemiology--the present status and future possibilities].
Topics: Animals; Base Sequence; Flavonoids; Genes, p53; Genes, Retinoblastoma; Genes, Tumor Suppressor; Humans; Methylation; Molecular Epidemiology; Molecular Sequence Data; Mutation; Neoplasms; Promoter Regions, Genetic; Prostaglandin D2 | 1996 |
Alcohol and cancer.
Topics: Animals; Carcinogens; Epidemiologic Factors; Esophageal Neoplasms; Ethanol; Folic Acid; Humans; Methylation; Mice; Murine Acquired Immunodeficiency Syndrome; Neoplasms; Vitamin E | 1994 |
Methioninase: a therapeutic for diseases related to altered methionine metabolism and transmethylation: cancer, heart disease, obesity, aging, and Parkinson's disease.
Topics: Aging; Animals; Carbon-Sulfur Lyases; Drug Interactions; Drug Therapy, Combination; Heart Diseases; Humans; Methionine; Methylation; Neoplasms; Obesity; Parkinson Disease; Recombinant Proteins | 1997 |
Lessons from basic research in selenium and cancer prevention.
Topics: Anticarcinogenic Agents; Dietary Supplements; Garlic; Humans; Methylation; Neoplasms; Plants, Medicinal; Selenium; Sodium Selenite | 1998 |
Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cell Cycle Proteins; Cell Division; Cysteine; Enzyme Inhibitors; Gene Expression Regulation; Humans; Methylation; Mice; Molecular Weight; Neoplasms; Neoplasms, Experimental; Oxidation-Reduction; Protein Kinase C; Proteins; Selenium; Selenocysteine; Selenoproteins; Thioredoxin-Disulfide Reductase; Thioredoxins; Transcription Factors | 1999 |
[Genome methylation and its role in functioning of the eukaryotic organism].
Topics: Animals; Chromatin; CpG Islands; DNA; DNA Modification Methylases; DNA Replication; DNA-Binding Proteins; Eukaryotic Cells; Genome; Genomic Imprinting; Humans; Methylation; Neoplasms; Protein Structure, Tertiary; Recombination, Genetic; Transcription, Genetic | 2000 |
Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications.
Topics: 5-Methylcytosine; Acetylation; Antineoplastic Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; CpG Islands; Cytosine; DNA Methylation; Fetal Hemoglobin; Gene Expression Regulation, Neoplastic; Hematologic Diseases; Histones; Humans; Methylation; Neoplasms | 2001 |
Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites.
Topics: Animals; Arsenic; Cell Division; Disease Models, Animal; DNA Methylation; DNA Repair; Genes, p53; Growth Substances; Humans; Methylation; Mice; Mice, Transgenic; Neoplasms; Rats | 2001 |
Histone methylation versus histone acetylation: new insights into epigenetic regulation.
Topics: Acetylation; Animals; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA Methylation; Gene Expression Regulation, Developmental; Gene Silencing; Heterochromatin; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms; Protein Methyltransferases; Transcription, Genetic | 2001 |
Catechol-O-Methyltransferase (COMT)-mediated methylation metabolism of endogenous bioactive catechols and modulation by endobiotics and xenobiotics: importance in pathophysiology and pathogenesis.
Topics: Animals; Catechol O-Methyltransferase; Catecholamines; Catechols; Dopamine; Enzyme Inhibitors; Estrogens; Humans; Kinetics; Methylation; Neoplasms; Parkinson Disease; Plant Preparations; Polymorphism, Genetic; Xenobiotics | 2002 |
The methylation of tRNA.
Topics: Animals; Base Sequence; Binding Sites; Cations, Monovalent; Cell Differentiation; Embryo, Mammalian; Escherichia coli; Gonadal Steroid Hormones; Humans; Methylation; Neoplasms; Nucleic Acid Conformation; Nucleosides; Polyamines; RNA, Transfer; S-Adenosylmethionine; Species Specificity; Structure-Activity Relationship; tRNA Methyltransferases | 1976 |
Catechol-O-methyl transferase: pharmacological aspects and physiological role.
Topics: Aging; Animals; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catecholamines; Catechols; Chickens; Female; Humans; Hypertension; Invertebrates; Isoenzymes; Isomerism; Kinetics; Mental Disorders; Methylation; Molecular Weight; Neoplasms; Plants; Pyrogallol; Rats; Subcellular Fractions; Tropolone; Uterus; Vertebrates | 1975 |
[Parental imprinting of mammalian genomes].
Topics: Alleles; Animals; Cell Differentiation; Chromatin; Chromosomes; DNA; Genetic Diseases, Inborn; Genome; Humans; Methylation; Mice; Mice, Inbred BALB C; Neoplasms | 1992 |
Abnormal regional hypermethylation in cancer cells.
Topics: Adult; DNA; Humans; Methylation; Neoplasms | 1992 |
Methylation, mutation and cancer.
Topics: 5-Methylcytosine; Animals; Cell Transformation, Neoplastic; Cytosine; Deamination; DNA; DNA, Neoplasm; Female; Genes, p53; Genetic Diseases, Inborn; Humans; Male; Methylation; Mutation; Neoplasms; Neoplasms, Experimental; Vertebrates | 1992 |
Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression.
Topics: Chromatin; DNA; Humans; Methylation; Neoplasms | 1991 |
Genomic imprinting.
Topics: Animals; Chromosome Aberrations; Chromosome Deletion; Chromosome Disorders; Dosage Compensation, Genetic; Gene Expression Regulation; Humans; Mammals; Methylation; Models, Genetic; Neoplasms; Parents; Phenotype; Ploidies; Syndrome | 1991 |
Current status of protein methylation in carcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Esterification; Histones; Humans; Methylation; Methyltransferases; Neoplasms; Nuclear Proteins; Proteins | 1991 |
Unbalanced transmethylation and the perturbation of the differentiated state leading to cancer.
Topics: Animals; DNA, Neoplasm; Genotype; Humans; Methionine; Methylation; Neoplasms | 1990 |
Exposure of humans to endogenous N-nitroso compounds: implications in cancer etiology.
Topics: Adenine; Bacterial Infections; Esophageal Neoplasms; Gastric Mucosa; Humans; Kinetics; Methylation; Neoplasms; Nicotiana; Nitrosamines; Nitrosation; Nitroso Compounds; Parasitic Diseases; Plants, Toxic; Stomach Neoplasms | 1990 |
The role of DNA methylation in cancer.
Topics: Animals; Carcinogens; DNA; Humans; Male; Methylation; Neoplasms; Signal Transduction; Spermatogenesis | 1990 |
DNA methylation and cancer.
Topics: Animals; Azacitidine; Cell Division; DNA (Cytosine-5-)-Methyltransferases; DNA Replication; DNA, Neoplasm; Eukaryotic Cells; Gene Expression Regulation; Humans; Methylation; Neoplasms | 1986 |
Labile methyl groups and the promotion of cancer.
Topics: Animals; Antibody Formation; Carcinogens; Choline; Choline Deficiency; Diet; DNA; Folic Acid; Folic Acid Deficiency; Humans; Immunity, Cellular; Lipotropic Agents; Liver; Liver Neoplasms; Methionine; Methylation; Neoplasms; Neoplasms, Experimental; Pharmaceutical Preparations; Risk; Tetrahydrofolates; Vitamin B 12; Vitamin B 12 Deficiency | 1986 |
Hypomethylation of DNA in the regulation of gene expression.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Differentiation; Cytosine; DNA; Gene Expression Regulation; Humans; Methylation; Methyltransferases; Neoplasms | 1988 |
Unequal parental contributions: genomic imprinting in mammals.
Topics: Animals; Disease Susceptibility; DNA; Dosage Compensation, Genetic; Embryonic and Fetal Development; Female; Gene Expression Regulation; Genetic Diseases, Inborn; Humans; Male; Methylation; Mice; Mice, Inbred Strains; Mice, Transgenic; Neoplasms; Nuclear Transfer Techniques; Sex Determination Analysis; X Chromosome; Zygote | 1989 |
Genetic and molecular aspects of human multigenerational carcinogenesis.
Topics: Animals; Eye Neoplasms; Humans; Kidney Neoplasms; Methylation; Mutation; Neoplasms; Retinoblastoma; Wilms Tumor | 1989 |
Altering gene expression with 5-azacytidine.
Topics: Anemia, Sickle Cell; Animals; Azacitidine; Cell Differentiation; Cell Line; DNA; Embryo, Mammalian; Embryo, Nonmammalian; Fetal Hemoglobin; Gene Expression Regulation; Genes; Genes, Regulator; Methylation; Mutation; Neoplasms; Thalassemia; Thymidine Kinase | 1985 |
[Clonal evolution in tumor cell population].
Topics: Animals; Biological Evolution; DNA Repair; DNA Replication; DNA, Neoplasm; Drug Resistance; Genetic Markers; Genetic Variation; Humans; Methylation; Mice; Neomycin; Neoplasms; Nondisjunction, Genetic; Sarcoma, Experimental; Selection, Genetic; Tumor Cells, Cultured | 1989 |
Tumor autocrine motility factor.
Topics: Cell Line; Cell Movement; Glucose-6-Phosphate Isomerase; Humans; Melanoma; Membrane Proteins; Methylation; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Oncogenes | 1986 |
Genetic instability and tumor progression.
Topics: Aneuploidy; Animals; Chromosome Aberrations; Clone Cells; DNA, Neoplasm; Gene Expression Regulation; Humans; Methylation; Models, Biological; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Neoplasms, Experimental; Oncogenes; Precancerous Conditions | 1986 |
DNA methylation and epigenetic defects in carcinogenesis.
Topics: Animals; DNA; Gene Expression Regulation; Humans; Methylation; Neoplasms | 1987 |
A unified theory for the development of cancer.
Topics: Animals; Cell Differentiation; Cell Transformation, Neoplastic; Gene Amplification; Gene Expression Regulation; Genes, Recessive; Humans; Methylation; Mutation; Neoplasms; Oncogenes; Retroviridae; Transduction, Genetic; Translocation, Genetic | 1986 |
Protein modification, metabolic controls, and their significance in transformation in eukaryotic cells.
Topics: Acetylation; Adenosine Triphosphate; Animals; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Chromosomes; Contact Inhibition; Cyclic AMP; DNA Replication; Glycoproteins; Inclusion Bodies; Methylation; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Neoplasms; Nucleoproteins; Oxidative Phosphorylation; Transcription, Genetic | 1974 |
Role of the methylated nucleic acids in carcinogenesis.
Topics: Animals; DNA, Neoplasm; Humans; Leukemia; Leukemia, Experimental; Methylation; Mice; Neoplasms; Neoplasms, Experimental; Nucleic Acids; RNA, Neoplasm; Species Specificity; Transferases | 1969 |
The possible role of nucleic acid methylases in the induction of cancer.
Topics: Alkylating Agents; Alkylation; Carcinogens; Cell Transformation, Neoplastic; DNA; Ethionine; Methylation; Methyltransferases; Neoplasms; Nucleic Acids; RNA, Neoplasm; RNA, Transfer; Transferases | 1971 |
Summary of symposium on transfer RNA and transfer RNA modification in differentiation and neoplasia.
Topics: Amino Acids; Base Sequence; Carcinogens; Cell Differentiation; Genes, Regulator; Genetic Code; Genetics, Medical; Genetics, Microbial; Methylation; Methyltransferases; Molecular Biology; Mutation; Neoplasms; RNA, Transfer; Suppression, Genetic; Transferases | 1971 |
2 trial(s) available for isomethyleugenol and Neoplasms
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide | 2023 |
Population pharmacokinetics of HM781-36 (poziotinib), pan-human EGF receptor (HER) inhibitor, and its two metabolites in patients with advanced solid malignancies.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biotransformation; Dose-Response Relationship, Drug; Drugs, Investigational; ErbB Receptors; Female; Food-Drug Interactions; Half-Life; Humans; Hydroxylation; Intestinal Absorption; Male; Metabolic Clearance Rate; Methylation; Middle Aged; Models, Biological; Neoplasms; Quinazolines; Tablets | 2015 |
345 other study(ies) available for isomethyleugenol and Neoplasms
Article | Year |
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METTL3-mediated m
Topics: Adenosine; Animals; Carcinogenesis; Cell Line, Tumor; Gene Deletion; Homeostasis; Interleukin-15; Killer Cells, Natural; Lymphocytes, Tumor-Infiltrating; Methylation; Methyltransferases; Mice, Inbred C57BL; Mice, Knockout; Neoplasms; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Proto-Oncogene Proteins c-akt; RNA; Signal Transduction; Tumor Microenvironment | 2021 |
Aberrant RNA methylation triggers recruitment of an alkylation repair complex.
Topics: AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase; Cell Nucleus; DNA Helicases; DNA Methylation; DNA-Binding Proteins; HEK293 Cells; HeLa Cells; Humans; Methylation; Neoplasms; Nuclear Proteins; R-Loop Structures; RNA Processing, Post-Transcriptional; RNA, Neoplasm; Spliceosomes; Transcription, Genetic; Ubiquitination | 2021 |
Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022.
Topics: Animals; China; Computational Biology; Databases, Factual; Databases, Genetic; Databases, Pharmaceutical; Dogs; Epigenome; Genome, Human; Genome, Viral; Genomics; Humans; Methylation; Neoplasms; Regeneration; SARS-CoV-2; Single-Cell Analysis; Software; Synthetic Biology | 2022 |
Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2.
Topics: Carcinogenesis; Cryoelectron Microscopy; DNA Methylation; Epigenomics; Histone-Lysine N-Methyltransferase; Histones; Humans; Kinetics; Methylation; Molecular Dynamics Simulation; Neoplasms; Oncogenes; Repressor Proteins | 2021 |
Methionine synthase supports tumour tetrahydrofolate pools.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Line, Tumor; Cell Proliferation; Folic Acid; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Metabolic Networks and Pathways; Methionine; Methylation; Mutation; Neoplasms; Purines; Tetrahydrofolates; Vitamin B 12 Deficiency | 2021 |
Identification of Pax protein inhibitors that suppress target gene expression and cancer cell proliferation.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Gene Expression; Kidney; Methylation; Mice; Neoplasms; PAX2 Transcription Factor | 2022 |
Regulation of PP2A, PP4, and PP6 holoenzyme assembly by carboxyl-terminal methylation.
Topics: Animals; Cell Line, Tumor; Gene Expression Regulation, Enzymologic; HEK293 Cells; HeLa Cells; Humans; Mass Spectrometry; MCF-7 Cells; Methylation; Mice; Neoplasms; Neurodegenerative Diseases; Phosphoprotein Phosphatases; Phosphorylation; Protein Domains; Protein Interaction Mapping; Protein Phosphatase 2; Protein Processing, Post-Translational; Proteomics | 2021 |
Models based on nucleic acid methylation regulators will contribute to facilitating cancer precision medicine.
Topics: Humans; Methylation; Neoplasms; Precision Medicine; RNA, Neoplasm | 2021 |
Application of droplet digital polymerase chain reaction of plasma methylated septin 9 on detection and early monitoring of colorectal cancer.
Topics: Area Under Curve; Biomarkers, Tumor; Cell Line, Tumor; Colorectal Neoplasms; DNA Methylation; Early Detection of Cancer; Epigenesis, Genetic; Female; Humans; Male; Methylation; Neoplasms; Polymerase Chain Reaction; Postoperative Period; ROC Curve; Septins | 2021 |
Tracking the Dynamic Histone Methylation of H3K27 in Live Cancer Cells.
Topics: Epigenesis, Genetic; Fluorescence Resonance Energy Transfer; Genome; Histones; Methylation; Neoplasms | 2021 |
Analysis of the expression patterns and clinical relevance of m
Topics: Biomarkers, Tumor; Computational Biology; Disease Progression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Methylation; Neoplasms; Prognosis; Sequence Analysis, RNA; Tumor Microenvironment | 2022 |
Palmitic acid: Enabling the tumor's nerves.
Topics: Epigenomics; Humans; Methylation; Neoplasms; Palmitic Acid; Tumor Microenvironment | 2022 |
Joint effects of genomic markers and urinary methylation capacity associated with inorganic arsenic metabolism on the occurrence of cancers among residents in arseniasis-endemic areas: A cohort subset with average fifteen-year follow-up.
Topics: Arsenic; Arsenicals; Follow-Up Studies; Genomics; Glutathione Transferase; Humans; Methylation; Methyltransferases; Neoplasms | 2021 |
Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
Topics: Animals; Enzyme Inhibitors; Histones; Humans; Methylation; Mice; Neoplasms; Polycomb Repressive Complex 2 | 2022 |
A Comprehensive Analysis of METTL1 to Immunity and Stemness in Pan-Cancer.
Topics: Humans; Immunotherapy; Methylation; Methyltransferases; Neoplasms; Prognosis; Tumor Microenvironment | 2022 |
Global analysis of protein arginine methylation.
Topics: Animals; Arginine; Methylation; Mice; Neoplasms; Protein Processing, Post-Translational; Proteins | 2021 |
A Novel Signature Based on m6A RNA Methylation Regulators Reveals Distinct Prognostic Subgroups and Associates with Tumor Immunity of Patients with Pancreatic Neuroendocrine Neoplasms.
Topics: Adenosine; Humans; Methylation; Multivariate Analysis; Neoplasms; Prognosis; RNA | 2022 |
Histone demethylase KDM4C is a functional dependency in JAK2-mutated neoplasms.
Topics: Animals; Histone Demethylases; Humans; Janus Kinase 2; Jumonji Domain-Containing Histone Demethylases; Methylation; Mice; Neoplasms; Signal Transduction | 2022 |
Arginine methylation of MTHFD1 by PRMT5 enhances anoikis resistance and cancer metastasis.
Topics: Anoikis; Arginine; Formate-Tetrahydrofolate Ligase; Humans; Methylation; Methylenetetrahydrofolate Dehydrogenase (NADP); Minor Histocompatibility Antigens; Neoplasms; Protein-Arginine N-Methyltransferases | 2022 |
Methionine deficiency facilitates antitumour immunity by altering m
Topics: Animals; CD8-Positive T-Lymphocytes; Methionine; Methylation; Mice; Neoplasms; Programmed Cell Death 1 Receptor; Racemethionine | 2023 |
PRMT5 activates AKT via methylation to promote tumor metastasis.
Topics: Arginine; Cell Line, Tumor; Humans; Methylation; Neoplasms; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins c-akt | 2022 |
Detection of Hypomethylation in Long-ctDNA.
Topics: Cell-Free Nucleic Acids; Circulating Tumor DNA; Humans; Methylation; Neoplasms | 2022 |
Re: Sabrina H. Rossi, Grant D. Stewart. Re: Clinical Validation of a Targeted Methylation-based Multi-cancer Early Detection Test Using an Independent Validation Set. Eur Urol. 2022;82:442-443.
Topics: Early Detection of Cancer; Humans; Methylation; Neoplasms | 2022 |
Pan-cancer landscape of abnormal ctDNA methylation across human tumors.
Topics: Biomarkers, Tumor; Circulating Tumor DNA; Humans; Methylation; Mutation; Neoplasms | 2022 |
Mutation-Agnostic Detection of Colorectal Cancer Using Liquid Biopsy-Based Methylation-Specific Signatures.
Topics: Biomarkers, Tumor; Circulating Tumor DNA; Colorectal Neoplasms; Humans; Liquid Biopsy; Methylation; Mutation; Neoplasms | 2023 |
Integrative Transcriptomic Analysis Identify Potential m6A Pathway-Related Drugs That Inhibit Cancer Cell Proliferation.
Topics: Adenosine; Cell Proliferation; Gene Expression Profiling; Humans; Methylation; Neoplasms; Transcriptome | 2022 |
NTRK-rearranged spindle cell neoplasms are ubiquitous tumours of myofibroblastic lineage with a distinct methylation class.
Topics: Adult; Child; Fibrosarcoma; Humans; Methylation; Neoplasms; Oncogene Proteins, Fusion; Receptor, trkA; RNA; Soft Tissue Neoplasms | 2023 |
Performance of a targeted methylation-based multi-cancer early detection test by race and ethnicity.
Topics: Early Detection of Cancer; Ethnicity; Humans; Methylation; Neoplasms; Prospective Studies; Socioeconomic Factors; United States | 2023 |
Exploratory Metabolomics Underscores the Folate Enzyme ALDH1L1 as a Regulator of Glycine and Methylation Reactions.
Topics: Aldehyde Dehydrogenase 1 Family; Folic Acid; Glycine; Humans; Metabolomics; Methylation; Neoplasms; Retinal Dehydrogenase; S-Adenosylmethionine | 2022 |
Design, synthesis and evaluation of antitumor activity of selective PRMT6 inhibitors.
Topics: Humans; Methylation; Neoplasms; Nuclear Proteins; Protein-Arginine N-Methyltransferases; Repressor Proteins | 2023 |
Peptides Targeting RNA m
Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Humans; Male; Methylation; Methyltransferases; Neoplasms; RNA; RNA, Messenger | 2023 |
Proof-of-Concept Method to Study Uncharacterized Methyltransferases Using PRDM15.
Topics: DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Methyltransferases; Neoplasms; Transcription Factors | 2023 |
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma.
Topics: Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Lymphoma; Methylation; Neoplasms; Polycomb Repressive Complex 2 | 2023 |
Detection of rare mutations, copy number alterations, and methylation in the same template DNA molecules.
Topics: 5-Methylcytosine; DNA; DNA Copy Number Variations; DNA Methylation; Female; Humans; Methylation; Mutation; Neoplasms | 2023 |
The beneficial effect of cyclohexyl substituent on the
Topics: Animals; Humans; Methylation; Mice; Neoplasms | 2023 |
The T1150A cancer mutant of the protein lysine dimethyltransferase NSD2 can introduce H3K36 trimethylation.
Topics: Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mutation; Neoplasms | 2023 |
Comments on "Methylation scores for smoking, alcohol consumption and body mass index and risk of seven types of cancer".
Topics: Alcohol Drinking; Body Mass Index; Humans; Methylation; Neoplasms; Risk Factors; Smoking | 2023 |
Reply to: Comments on "Methylation scores for smoking, alcohol consumption and body mass index and risk of seven types of cancer".
Topics: Alcohol Drinking; Body Mass Index; Humans; Methylation; Neoplasms; Risk Factors; Smoking | 2023 |
PARP1 modulates METTL3 promoter chromatin accessibility and associated LPAR5 RNA m
Topics: Animals; Chromatin; Humans; Methylation; Methyltransferases; Mice; Neoplasms; Poly (ADP-Ribose) Polymerase-1; Receptors, Lysophosphatidic Acid; RNA; RNA, Messenger; Transcription Factors | 2023 |
Integrative Multi-Omics Analysis of Oncogenic EZH2 Mutants: From Epigenetic Reprogramming to Molecular Signatures.
Topics: Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Histones; Humans; Methylation; Multiomics; Neoplasms; Polycomb Repressive Complex 2 | 2023 |
Manipulating mitochondrial electron flow enhances tumor immunogenicity.
Topics: Antigen Presentation; Antigens, Neoplasm; Cell Line, Tumor; Electron Transport Complex I; Electron Transport Complex II; Electrons; Gene Knockout Techniques; Histones; HSP40 Heat-Shock Proteins; Humans; Melanoma; Methylation; Mitochondria; Neoplasms | 2023 |
Rare de novo gain-of-function missense variants in DOT1L are associated with developmental delay and congenital anomalies.
Topics: Congenital Abnormalities; Developmental Disabilities; Drosophila; Drosophila Proteins; Gain of Function Mutation; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms | 2023 |
Protein methylation characterization using NMR without isotopic labeling.
Topics: Animals; Histone-Lysine N-Methyltransferase; Histones; Methylation; Mice; Neoplasms | 2024 |
Histone methyltransferase activity affects metabolism in human cells independently of transcriptional regulation.
Topics: Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational; S-Adenosylmethionine | 2023 |
Metabolic sinkholes: Histones as methyl repositories.
Topics: Gene Expression Regulation; Histone Methyltransferases; Histones; Humans; Methylation; Neoplasms | 2023 |
FunDMDeep-m6A: identification and prioritization of functional differential m6A methylation genes.
Topics: Animals; Humans; Methylation; Neoplasms; Protein Interaction Maps; RNA; RNA, Messenger; Software | 2019 |
Molecular characterization and clinical relevance of m
Topics: Adenosine; Computational Biology; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genetic Variation; Humans; Methylation; Neoplasms; Prognosis; Signal Transduction | 2019 |
The Transsulfuration Pathway Makes, the Tumor Takes.
Topics: Cysteine; Humans; Methionine; Methylation; Neoplasms | 2019 |
One-carbon metabolism for cancer diagnostic and therapeutic approaches.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Carbon; DNA; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Metabolic Networks and Pathways; Methylation; Neoplasms | 2020 |
Bregmannian consensus clustering for cancer subtypes analysis.
Topics: Algorithms; Cluster Analysis; Gene Expression Profiling; Methylation; MicroRNAs; Neoplasms; RNA, Messenger | 2020 |
Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A.
Topics: Biocatalysis; Histones; Humans; Methylation; Neoplasms; Retinoblastoma-Binding Protein 2; Substrate Specificity | 2020 |
Potential 2,4-dimethyl-1H-pyrrole-3-carboxamide bearing benzimidazole template: Design, synthesis, in vitro anticancer and in silico ADME study.
Topics: Antineoplastic Agents; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Humans; Methylation; Models, Molecular; Neoplasms; Pyrroles; Structure-Activity Relationship | 2020 |
A novel EZH2 inhibitor induces synthetic lethality and apoptosis in PBRM1-deficient cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Indoles; Lysine; Methylation; Molecular Docking Simulation; Molecular Dynamics Simulation; Neoplasms; Prognosis; Pyridones; Reproducibility of Results; Synthetic Lethal Mutations; Transcription Factors | 2020 |
Proteomic Analyses Identify a Novel Role for EZH2 in the Initiation of Cancer Cell Drug Tolerance.
Topics: Drug Tolerance; Enhancer of Zeste Homolog 2 Protein; Histones; Methylation; Neoplasms; Polycomb Repressive Complex 2; Proteomics | 2020 |
The pan-cancer landscape of netrin family reveals potential oncogenic biomarkers.
Topics: Biomarkers, Tumor; Endometrial Neoplasms; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; GPI-Linked Proteins; Humans; Kaplan-Meier Estimate; Methylation; Mutation Rate; Neoplasms; Netrins; Quantitative Trait Loci | 2020 |
Using methylation signatures on cell-free DNA for early cancer detection: a new era in liquid biopsy?
Topics: Biomarkers, Tumor; Cell-Free Nucleic Acids; DNA Methylation; Early Detection of Cancer; Humans; Liquid Biopsy; Methylation; Neoplasms | 2020 |
On a New Proposed Mechanism of 5-Fluorouracil-Mediated Cytotoxicity.
Topics: Cell Cycle; Cell Survival; DNA Damage; Fluorouracil; Humans; Methylation; Neoplasms; Recombinational DNA Repair; RNA, Transfer; tRNA Methyltransferases; Uridine Triphosphate | 2020 |
[mRNA methylation regulates cross-presentation of tumor-derived antigens].
Topics: Antigen Presentation; Antigens, Neoplasm; Cross-Priming; Dendritic Cells; Humans; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Messenger | 2020 |
Oncometabolites suppress DNA repair by disrupting local chromatin signalling.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; Chromatin; DNA Breaks; DNA Repair; Homologous Recombination; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine Acetyltransferase 5; Methylation; Neoplasms; Poly(ADP-ribose) Polymerase Inhibitors; Signal Transduction | 2020 |
m
Topics: Animals; Cell Line, Tumor; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA Breaks, Double-Stranded; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Homologous Recombination; Humans; Methylation; Mice; Neoplasms; Poly(ADP-ribose) Polymerase Inhibitors; Rad51 Recombinase; Rad52 DNA Repair and Recombination Protein; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Small Interfering; Xenograft Model Antitumor Assays | 2020 |
Host-Guest Protein Assembly for Affinity Purification of Methyllysine Proteomes.
Topics: Amantadine; Bridged-Ring Compounds; Chromatography, Affinity; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; HeLa Cells; Humans; Imidazoles; Lysine; Methylation; Neoplasms; Peptides | 2020 |
RNA N-6-methyladenosine enzymes and resistance of cancer cells to chemotherapy and radiotherapy.
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Cell Cycle Proteins; Drug Resistance, Neoplasm; Humans; Methylation; Methyltransferases; Neoplasms; Radiation Tolerance; RNA; RNA Splicing Factors | 2020 |
Ibuprofen mediates histone modification to diminish cancer cell stemness properties via a COX2-dependent manner.
Topics: A549 Cells; Acetylation; Animals; Cell Line, Tumor; Cyclooxygenase 2; Drug Resistance, Neoplasm; Female; Hep G2 Cells; Histone Deacetylases; Histones; Humans; Ibuprofen; Intercellular Adhesion Molecule-3; Methylation; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Neoplasm Metastasis; Neoplasms; Neoplastic Stem Cells; Random Allocation | 2020 |
Response to W.C. Taylor, and C. Fiala and E.P. Diamandis.
Topics: Cell-Free Nucleic Acids; Humans; Methylation; Models, Biological; Neoplasms | 2020 |
Recoding the Cancer Epigenome by Intervening in Metabolism and Iron Homeostasis with Mitochondria-Targeted Rhenium(I) Complexes.
Topics: Animals; Apoptosis; Cell Line, Tumor; Coordination Complexes; Deferasirox; Drug Evaluation, Preclinical; Epigenomics; Histones; Humans; Iron; Iron Chelating Agents; Methylation; Mice; Mitochondria; Neoplasms; Reactive Oxygen Species; Receptors, Antigen, T-Cell; Rhenium; RNA Polymerase II; Signal Transduction | 2020 |
Methio "mine"! Cancer cells steal methionine and impair CD8 T-cell function.
Topics: CD8-Positive T-Lymphocytes; Histones; Humans; Methionine; Methylation; Neoplasms; STAT5 Transcription Factor | 2020 |
Aspirin mediates histone methylation that inhibits inflammation-related stemness gene expression to diminish cancer stemness via COX-independent manner.
Topics: Aspirin; Cell Line, Tumor; Gene Expression; Histones; Humans; Inflammation; Methylation; Neoplasms; Neoplastic Stem Cells; Phosphatidylinositol 3-Kinases | 2020 |
Cancer SLC43A2 alters T cell methionine metabolism and histone methylation.
Topics: Amino Acid Transport System L; Animals; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Epigenesis, Genetic; Female; Histones; Humans; Methionine; Methylation; Mice; Neoplasms; Receptors, Antigen, T-Cell; STAT5 Transcription Factor | 2020 |
Computational prediction and analysis of histone H3k27me1-associated miRNAs.
Topics: Computational Biology; Computer Simulation; Gene Expression Regulation, Neoplastic; Gene Ontology; Histones; Humans; Machine Learning; Methylation; MicroRNAs; Models, Genetic; Neoplasm Proteins; Neoplasms; Signal Transduction; Transcription Factors | 2021 |
Hsp90 regulates HDAC3-dependent gene transcription while HDAC3 regulates the functions of Hsp90.
Topics: Acetylation; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; HSP90 Heat-Shock Proteins; Humans; MCF-7 Cells; Methylation; Neoplasms | 2020 |
A Tug-of-War Over Methionine.
Topics: Histones; Methionine; Methylation; Neoplasms; S-Adenosylmethionine; T-Lymphocytes | 2020 |
A role of glycation and methylation for SARS-CoV-2 infection in diabetes?
Topics: Adipose Tissue; Angiotensin-Converting Enzyme 2; Biomarkers; Comorbidity; COVID-19; Diabetes Complications; Diabetes Mellitus, Type 2; DNA Methylation; Glycosylation; Humans; Immunoglobulin G; Insulin Resistance; Methylation; Multicenter Studies as Topic; Neoplasms; Protein Domains; Renin-Angiotensin System; Retrospective Studies; SARS-CoV-2; Up-Regulation | 2020 |
Regulating Tumor N
Topics: Cell Line, Tumor; Doxorubicin; Humans; Hypoxia; Methylation; Nanoparticles; Neoplasms; Polyethylene Glycols | 2021 |
Identification of hnRNP-A1 as a pharmacodynamic biomarker of type I PRMT inhibition in blood and tumor tissues.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Immunological; Arginine; Biomarkers; Cells, Cultured; Chromatography, Liquid; Drug Monitoring; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Heterogeneous Nuclear Ribonucleoprotein A1; Humans; Leukocytes, Mononuclear; Mass Spectrometry; Methylation; Mice; Molecular Targeted Therapy; Neoplasms; Protein-Arginine N-Methyltransferases; Repressor Proteins; Substrate Specificity | 2020 |
FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells.
Topics: Adult; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Breaks, Double-Stranded; DNA Replication; Drug Resistance, Neoplasm; F-Box Proteins; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Immune Checkpoint Inhibitors; Immunity; Interferons; Lysine; Male; Methylation; Middle Aged; Neoplasm Proteins; Neoplasms; Nucleosomes; Repetitive Sequences, Nucleic Acid; Signal Transduction; Transcription, Genetic; Treatment Outcome | 2021 |
Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.
Topics: Binding Sites; Biocatalysis; Cell Line, Tumor; Cell Proliferation; Cryoelectron Microscopy; Heterografts; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Models, Molecular; Multiprotein Complexes; Mutation; Neoplasm Transplantation; Neoplasms; Nuclear Proteins; Nucleosomes; Phenotype; Protein Binding; Repressor Proteins | 2021 |
An epigenetic tipping point in cancer comes under the microscope.
Topics: Epigenesis, Genetic; Humans; Methylation; Methyltransferases; Neoplasms; Nucleosomes | 2021 |
Pan-cancer characterization of expression and clinical relevance of m
Topics: Adenosine; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Methylation; Neoplasm Staging; Neoplasms; Organ Specificity; Prognosis; RNA, Long Noncoding | 2021 |
Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinogenesis; Cell Line; Chromatin; CRISPR-Cas Systems; Cytarabine; Decitabine; Epigenesis, Genetic; Gene Editing; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Mesenchymal Stem Cells; Methylation; Mice; Mutation; Neoplasm Proteins; Neoplasms; Phenotype; Protein Isoforms; Protein Processing, Post-Translational; Repressor Proteins; Transcriptome | 2021 |
RNA N6-methyladenosine: a new player in autophagy-mediated anti-cancer drug resistance.
Topics: Adenosine; Autophagy; Disease Progression; Drug Resistance, Neoplasm; Humans; Methylation; Methyltransferases; Neoplasms; RNA; RNA Processing, Post-Transcriptional | 2021 |
A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation.
Topics: Animals; Binding Sites; Enhancer Elements, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Reporter; Histone Demethylases; Histones; Homeostasis; Humans; Methylation; Mice; Neoplasms; NIH 3T3 Cells; Nucleocytoplasmic Transport Proteins; Promoter Regions, Genetic; R-Loop Structures; Recombinant Proteins; RNA Interference; Transcription, Genetic | 2021 |
Comprehensive analyses of m6A regulators and interactive coding and non-coding RNAs across 32 cancer types.
Topics: Adenosine; Biomarkers, Tumor; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; Organ Specificity; RNA, Messenger; RNA, Untranslated | 2021 |
Determination of Polycyclic Aromatic Hydrocarbons and Their Methylated Derivatives in Sewage Sludge from Northeastern China: Occurrence, Profiles and Toxicity Evaluation.
Topics: Agriculture; China; Chromatography, High Pressure Liquid; Environmental Monitoring; Methylation; Neoplasms; Polycyclic Aromatic Hydrocarbons; Quality Control; Risk Assessment; Sewage; Soil Pollutants; Toxicity Tests | 2021 |
METTL1-mediated m
Topics: Carcinogenesis; Guanosine; Humans; Methylation; Methyltransferases; Neoplasms; Oncogenes; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Transfer; tRNA Methyltransferases | 2021 |
Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure.
Topics: Animals; Antineoplastic Agents; Chromatin; Drug Resistance, Neoplasm; Epigenetic Repression; Gene Expression Regulation, Neoplastic; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Humans; Long Interspersed Nucleotide Elements; Methylation; Mice; Mice, Nude; Mice, SCID; Neoplasms; Stress, Physiological; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2017 |
MUC1-C activates EZH2 expression and function in human cancer cells.
Topics: A549 Cells; Antigens, CD; Binding Sites; BRCA1 Protein; Cadherins; Cell Line, Tumor; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Mucin-1; Neoplasms; Promoter Regions, Genetic; Signal Transduction; Transcriptional Activation | 2017 |
EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms.
Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Transformation, Neoplastic; Cytoplasm; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HEK293 Cells; Humans; Janus Kinase 2; Jurkat Cells; Methylation; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; Mutagenesis, Site-Directed; Neoplasms; Nuclear Localization Signals; Proto-Oncogene Proteins c-vav; Recombinant Proteins; STAT3 Transcription Factor; Talin; Xenograft Model Antitumor Assays | 2018 |
Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Demethylases; Humans; Methylation; Molecular Docking Simulation; Neoplasms; Tranylcypromine | 2017 |
Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines.
Topics: Antineoplastic Agents; Carcinogens; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Humans; Isoenzymes; Lyngbya Toxins; Methylation; Neoplasms; Protein Kinase C | 2018 |
Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway.
Topics: Apoptosis; Azepines; Cell Cycle; Cell Hypoxia; Cell Movement; Cell Proliferation; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MCF-7 Cells; Methylation; Neoplasms; Oncogenes; Prognosis; Quinazolines; Signal Transduction | 2017 |
Genetic variants in the histone methylation and acetylation pathway and their risks in eight types of cancers.
Topics: Acetylation; Genetic Predisposition to Disease; Genetic Variation; Germ-Line Mutation; Histones; Humans; Methylation; Neoplasms; Polymorphism, Single Nucleotide; Signal Transduction | 2018 |
Primary aminomethyl derivatives of kaempferol: hydrogen bond-assisted synthesis, anticancer activity and spectral properties.
Topics: Amination; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Hydrogen Bonding; Kaempferols; Methylation; Models, Molecular; Neoplasms | 2018 |
N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent.
Topics: Animals; Female; Gallium Radioisotopes; Humans; Integrin alpha5beta1; Ligands; Magnetic Resonance Spectroscopy; Melanoma, Experimental; Methylation; Mice; Mice, SCID; Models, Molecular; Molecular Structure; Neoplasms; Peptides; Positron-Emission Tomography; Protein Binding; Radioactive Tracers; Tissue Distribution; Xenograft Model Antitumor Assays | 2018 |
Global delay in nascent strand DNA methylation.
Topics: Cell Cycle; Cell Proliferation; CpG Islands; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA Replication; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Regulation; Genome, Human; HCT116 Cells; Humans; Male; Methylation; Mitosis; Motor Neurons; Neoplasms; Sequence Analysis, RNA; Transcription Factors | 2018 |
A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.
Topics: Amino Acid Sequence; Animals; Cell Differentiation; Cell Line; HEK293 Cells; Histones; Humans; Methylation; Methyltransferases; Mice; Neoplasms; Polycomb Repressive Complex 2; Repressor Proteins; Sequence Alignment; Vertebrates | 2018 |
Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing.
Topics: Alternative Splicing; Cell Line, Tumor; Cluster Analysis; Exons; Gene Expression Regulation, Neoplastic; Gene Ontology; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms; Nucleotide Motifs; Reproducibility of Results; RNA Splice Sites | 2018 |
Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width.
Topics: Animals; Gene Expression Profiling; Genomics; HCT116 Cells; Histone Code; Histones; Humans; Liver; Lysine; Male; Methionine; Methylation; Mice, Inbred C57BL; Neoplasms | 2018 |
Methylation of Aurora kinase A by MMSET reduces p53 stability and regulates cell proliferation and apoptosis.
Topics: Apoptosis; Aurora Kinase A; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; HCT116 Cells; Histone-Lysine N-Methyltransferase; Humans; Methylation; Neoplasms; Repressor Proteins; Tumor Suppressor Protein p53 | 2018 |
[Expression changes of tumor-related gene mRNA in workers who smelt arsenic].
Topics: Animals; Arsenic; Arsenicals; Humans; Methylation; Neoplasms; Occupational Exposure; RNA, Messenger; Spectrophotometry, Atomic | 2018 |
Methylation and MicroRNA Profiling to Understand Racial Disparities of Prostate Cancer.
Topics: Biomarkers, Tumor; Cell Transformation, Neoplastic; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; High-Throughput Nucleotide Sequencing; Humans; Incidence; Male; Methylation; MicroRNAs; Neoplasms; Population Groups; Prevalence; Risk Factors | 2018 |
Human SETMAR is a DNA sequence-specific histone-methylase with a broad effect on the transcriptome.
Topics: Animals; DNA Transposable Elements; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Neoplasms; Primates; Signal Transduction; Transcription Factors; Transcriptome | 2019 |
RNA Modifications: Reversal Mechanisms and Cancer.
Topics: Alkylation; Epigenesis, Genetic; Humans; Methylation; Neoplasms; RNA; RNA Processing, Post-Transcriptional | 2019 |
Identification of selective and reversible LSD1 inhibitors with anti-metastasis activity by high-throughput docking.
Topics: Cell Line, Tumor; Demethylation; Enzyme Inhibitors; Histone Demethylases; Histones; Humans; Lysine; Methylation; Molecular Docking Simulation; Neoplasm Metastasis; Neoplasms; Structure-Activity Relationship | 2019 |
The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C.
Topics: Amino Acid Sequence; Bridged Bicyclo Compounds, Heterocyclic; Catalysis; Catalytic Domain; Cell Line, Tumor; Humans; Metals; Methylation; Mutagenesis, Site-Directed; Neoplasms; Nuclear Proteins; Phosphoprotein Phosphatases; Piperazines; Protein Phosphatase 2 | 2019 |
AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions.
Topics: Animals; Antibiotics, Antineoplastic; Carcinogenesis; Cell Line, Tumor; Female; HEK293 Cells; Histone-Lysine N-Methyltransferase; Humans; Methylation; Mice, Nude; Mice, Transgenic; Neoplasms; Plicamycin; Protein Methyltransferases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Sf9 Cells; Spodoptera; Xenograft Model Antitumor Assays | 2019 |
Altered Methionine Metabolism in Cancer Cells.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Homocysteine; Humans; Methionine; Methylation; Neoplasms; S-Adenosylhomocysteine; S-Adenosylmethionine | 2019 |
Linkage of Methionine Dependence and Other Features of Malignancy.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cell Line, Tumor; Cell Proliferation; Humans; Methionine; Methylation; Neoplasms; Rats | 2019 |
Anti-tumour immunity controlled through mRNA m
Topics: Adenosine; Animals; Antigen Presentation; Antigens, Neoplasm; B7-H1 Antigen; Binding Sites; Cathepsins; CD8-Positive T-Lymphocytes; Cross-Priming; Dendritic Cells; Female; Humans; Methylation; Mice; Mice, Inbred C57BL; Neoplasms; Protein Biosynthesis; Proteins; RNA-Binding Proteins; RNA, Messenger; Transcriptome | 2019 |
DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns.
Topics: 5-Methylcytosine; Animals; Cell Line, Tumor; CpG Islands; DNA Methylation; DNA-Binding Proteins; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Histones; Humans; Male; Methylation; Mice, Inbred C57BL; Mice, Knockout; Myeloid-Lymphoid Leukemia Protein; Neoplasm Proteins; Neoplasms; Promoter Regions, Genetic | 2019 |
PTEN arginine methylation by PRMT6 suppresses PI3K-AKT signaling and modulates pre-mRNA splicing.
Topics: Alternative Splicing; Cell Line, Tumor; HEK293 Cells; Humans; Methylation; Neoplasm Proteins; Neoplasms; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; RNA Precursors; RNA, Neoplasm; Signal Transduction | 2019 |
The expanding landscape of 'oncohistone' mutations in human cancers.
Topics: Cell Transformation, Neoplastic; Histones; Humans; Lysine; Methylation; Mutation; Neoplasms; Nucleosomes; Protein Domains; Protein Processing, Post-Translational | 2019 |
Translate less, prime better, to improve anti-tumor responses.
Topics: Dendritic Cells; HIV-1; Humans; Methylation; Neoplasms; RNA-Binding Proteins; RNA, Messenger | 2019 |
YTHDF1 Control of Dendritic Cell Cross-Priming as a Possible Target of Cancer Immunotherapy.
Topics: Cross-Priming; Dendritic Cells; Humans; Immunotherapy; Methylation; Neoplasms; RNA-Binding Proteins; RNA, Messenger | 2019 |
Fine-tuning AKT kinase activity through direct lysine methylation.
Topics: Animals; Carcinogenesis; Histone-Lysine N-Methyltransferase; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt | 2019 |
PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage.
Topics: Animals; Binding Sites; Cell Line, Tumor; DNA Breaks, Double-Stranded; Female; HCT116 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Mice; Neoplasms; NIH 3T3 Cells; Phosphorylation; PTEN Phosphohydrolase; Repressor Proteins; Tumor Suppressor p53-Binding Protein 1 | 2019 |
Somatic Cancer Mutations in the SUV420H1 Protein Lysine Methyltransferase Modulate Its Catalytic Activity.
Topics: Amino Acid Sequence; Animals; Cell Line, Tumor; DNA Repair; Fibroblasts; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Neoplasms; Nucleosomes; S-Adenosylmethionine | 2019 |
M-TAP Dance: Targeting PRMT1 and PRMT5 Family Members to Push Cancer Cells Over the Edge.
Topics: Dancing; Enzyme Inhibitors; Humans; Methylation; Neoplasms; Protein-Arginine N-Methyltransferases; Repressor Proteins | 2019 |
Determination of the in vitro metabolic stability and metabolites of the anticancer derivative riccardin D-N in human and mouse hepatic S9 fractions using HPLC-Q-LIT-MS.
Topics: Animals; Antineoplastic Agents; Calibration; Chromatography, High Pressure Liquid; Humans; Hydrogen; Hydroxylation; Liver; Methylation; Mice; Microsomes, Liver; Neoplasms; Oxygen; Phenyl Ethers; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Stilbenes | 2019 |
Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity.
Topics: Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Humans; Methylation; Molecular Docking Simulation; Neoplasms; Protein Binding; Protein-Arginine N-Methyltransferases; Pyrimidines; Pyrroles; Quinolines; Structure-Activity Relationship; Triazoles | 2019 |
NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink.
Topics: Epigenesis, Genetic; Humans; Methionine; Methylation; Models, Genetic; Neoplasms; Niacinamide; Nicotinamide N-Methyltransferase | 2013 |
Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase.
Topics: Benzoquinones; Cell Line, Tumor; Enzyme Inhibitors; Enzyme Stability; Histones; HSP90 Heat-Shock Proteins; Humans; Jumonji Domain-Containing Histone Demethylases; Lactams, Macrocyclic; Methylation; Neoplasm Proteins; Neoplasms; Proteasome Endopeptidase Complex; Proteolysis; Ubiquitin | 2013 |
Epigenomic analysis of multilineage differentiation of human embryonic stem cells.
Topics: Animals; Cell Differentiation; Chromatin; CpG Islands; DNA Methylation; Embryonic Stem Cells; Epigenomics; Gene Expression Regulation, Developmental; Histones; Humans; Methylation; Neoplasms; Promoter Regions, Genetic; Zebrafish | 2013 |
A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Epigenesis, Genetic; Histones; Humans; Hydrazones; Inhibitory Concentration 50; Isomerism; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Neoplasms; Small Molecule Libraries; Survival Analysis; Transcription, Genetic | 2013 |
The protein-protein interaction network of the human Sirtuin family.
Topics: Acetylation; Aging; Computational Biology; Databases, Protein; Humans; Methylation; Neoplasms; Phosphorylation; Protein Interaction Mapping; Protein Interaction Maps; Protein Processing, Post-Translational; Sirtuins | 2013 |
EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers.
Topics: Actin Cytoskeleton; Adenosine; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Enhancer of Zeste Homolog 2 Protein; Epigenetic Repression; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Histones; Humans; Methylation; Neoplasms; Promoter Regions, Genetic; RNA, Messenger; Tumor Suppressor Proteins | 2013 |
KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors.
Topics: Chromatin; Chromosomes, Human, Pair 1; DNA Replication; Gene Dosage; Genomic Instability; HEK293 Cells; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Neoplasms; Protein Structure, Tertiary; S Phase | 2013 |
The malignant brain tumor (MBT) domain protein SFMBT1 is an integral histone reader subunit of the LSD1 demethylase complex for chromatin association and epithelial-to-mesenchymal transition.
Topics: Carcinogens; Chromatin; Epithelial Cells; Epithelial-Mesenchymal Transition; HEK293 Cells; Histone Demethylases; Histones; Humans; Methylation; Neoplasm Proteins; Neoplasms; Nickel; Repressor Proteins; Snail Family Transcription Factors; Trace Elements; Transcription Factors | 2013 |
Promoter histone H3K27 methylation in the control of IGF2 imprinting in human tumor cell lines.
Topics: Alleles; Binding Sites; CCCTC-Binding Factor; Cell Line; Chromatin; Chromatin Immunoprecipitation; DNA Methylation; Gene Expression Regulation, Neoplastic; Genomic Imprinting; Histones; HT29 Cells; Humans; Insulin-Like Growth Factor II; Methylation; Neoplasm Proteins; Neoplasms; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Repressor Proteins; Transcription Factors | 2014 |
p53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromosomal Proteins, Non-Histone; Female; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; Peptide Chain Initiation, Translational; Prognosis; Protein Binding; Protein Biosynthesis; RNA, Ribosomal; Tumor Suppressor Protein p53 | 2013 |
Safe and easy route for the synthesis of 1,3-dimethyl-1,2,3-triazolium salt and investigation of its anticancer activities.
Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; Methylation; Neoplasms; Triazoles | 2013 |
The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.
Topics: Animals; DNA-Binding Proteins; Enhancer Elements, Genetic; Epigenesis, Genetic; Gene Expression; HCT116 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Mice; Neoplasms; Protein Processing, Post-Translational; Protein Transport | 2013 |
Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.
Topics: HEK293 Cells; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Hydrophobic and Hydrophilic Interactions; Intracellular Signaling Peptides and Proteins; Methylation; Neoplasm Proteins; Neoplasms; Protein-Arginine N-Methyltransferases; S-Adenosylmethionine; Substrate Specificity | 2013 |
Statistical and practical considerations for clinical evaluation of predictive biomarkers.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; ErbB Receptors; Gefitinib; Glioblastoma; Humans; Indazoles; Interleukin-6; Kidney Neoplasms; Lung Neoplasms; Methylation; Molecular Targeted Therapy; Mutation; Neoplasms; Precision Medicine; Predictive Value of Tests; Pyrimidines; Quinazolines; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Sample Size; Sulfonamides; Temozolomide; Tumor Suppressor Proteins | 2013 |
KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation.
Topics: Cell Growth Processes; Cell Movement; DNA-Binding Proteins; Histone Acetyltransferases; Histone Demethylases; Histones; Humans; Methylation; Neoplasm Proteins; Neoplasms; Transfection | 2013 |
Natural variation in the histone demethylase, KDM4C, influences expression levels of specific genes including those that affect cell growth.
Topics: Cell Proliferation; Cells, Cultured; Epigenesis, Genetic; Gene Expression Regulation; Gene Knockdown Techniques; Genetic Linkage; Genetic Variation; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Neoplasms; Phenotype | 2014 |
Lysine methylation promotes VEGFR-2 activation and angiogenesis.
Topics: Animals; Cell Line, Tumor; HEK293 Cells; Heterografts; Humans; Lysine; Methylation; Mice; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Protein Processing, Post-Translational; Vascular Endothelial Growth Factor Receptor-2; Zebrafish; Zebrafish Proteins | 2013 |
2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Halogenation; Humans; Methylation; Molecular Docking Simulation; Neoplasms; Quinoxalines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2014 |
Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway.
Topics: Cell Line, Tumor; Down-Regulation; Glucose; Glycolysis; Heme Oxygenase (Decyclizing); Humans; Methylation; Neoplasms; Oxidative Stress; Pentose Phosphate Pathway; Phosphofructokinase-2 | 2014 |
S-score: a scoring system for the identification and prioritization of predicted cancer genes.
Topics: Computational Biology; DNA Copy Number Variations; Female; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Genomics; Humans; Methylation; Mutation; Neoplasms; Oncogenes | 2014 |
Enhanced arginine methylation of programmed cell death 4 protein during nutrient deprivation promotes tumor cell viability.
Topics: Apoptosis Regulatory Proteins; Arginine; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasm Proteins; Neoplasms; Phosphorylation; Protein-Arginine N-Methyltransferases; RNA-Binding Proteins; Up-Regulation | 2014 |
Biological evaluation and SAR analysis of O-methylated analogs of quercetin as inhibitors of cancer cell proliferation.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Methylation; Molecular Structure; Neoplasms; Quercetin; Structure-Activity Relationship | 2014 |
Polycomb repressive complex 2 and H3K27me3 cooperate with H3K9 methylation to maintain heterochromatin protein 1α at chromatin.
Topics: Animals; Cell Cycle; Cell Line, Tumor; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Histones; Humans; Methylation; Mice; Models, Molecular; Neoplasms; Polycomb Repressive Complex 2; Proteasome Endopeptidase Complex; Protein Stability | 2014 |
Synthesis and cytotoxic activity of 1-{3-[1-(5-organylsilylfuran-2-yl)silinan-1-yl]propyl}amines and some trimethylgermyl analogues.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Germanium; Humans; Methylation; Mice; Neoplasms; NIH 3T3 Cells; Organosilicon Compounds | 2014 |
Synthesis of IB-01212 by multiple N-methylations of peptide bonds.
Topics: Amino Acid Sequence; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Depsipeptides; Humans; Methylation; Neoplasms | 2014 |
Enzymatic methylation and structure-activity-relationship studies on polycarcin V, a gilvocarcin-type antitumor agent.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Coumarins; Glycosides; Humans; Methylation; Neoplasms; Streptomyces; Structure-Activity Relationship | 2014 |
Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2.
Topics: Astemizole; Binding, Competitive; Catalysis; Catalytic Domain; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Progression; Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Lymphoma; Magnetic Resonance Spectroscopy; Methylation; Models, Molecular; Molecular Docking Simulation; Neoplasms; Polycomb Repressive Complex 2; Protein Interaction Mapping; Protein Processing, Post-Translational | 2014 |
Total syntheses and biological evaluation of miuraenamides.
Topics: Actins; Antineoplastic Agents; Cell Line, Tumor; Depsipeptides; Humans; Methylation; Neoplasms; Oxidation-Reduction | 2015 |
Somatic cancer mutations in the DNMT2 tRNA methyltransferase alter its catalytic properties.
Topics: Amino Acid Substitution; Animals; Catalysis; DNA (Cytosine-5-)-Methyltransferases; Humans; Methylation; Mice; Mutation, Missense; Neoplasm Proteins; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Transfer, Asp | 2015 |
3-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, nortopsentin analogues with antiproliferative activity.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Design; G2 Phase; Halogenation; Humans; Imidazoles; Indoles; Membrane Potential, Mitochondrial; Methylation; Mitochondria; Molecular Structure; Neoplasms; Pyridines; Pyrroles; Resting Phase, Cell Cycle; Thiazoles | 2015 |
Comparative methylome analysis in solid tumors reveals aberrant methylation at chromosome 6p in nasopharyngeal carcinoma.
Topics: Carcinoma; Chromosomes, Human, Pair 6; Computational Biology; CpG Islands; DNA Methylation; Epigenesis, Genetic; Epigenomics; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Meta-Analysis as Topic; Methylation; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms; Promoter Regions, Genetic; Transcriptome | 2015 |
Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Catechin; Cell Proliferation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavonols; Humans; Methylation; Models, Molecular; Molecular Structure; Neoplasm Proteins; Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured | 2015 |
Structure-activity relationship studies of 4-methylcoumarin derivatives as anticancer agents.
Topics: Antineoplastic Agents; Cell Survival; Coumarins; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; K562 Cells; MCF-7 Cells; Methylation; Molecular Structure; Neoplasms; Structure-Activity Relationship | 2016 |
SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells.
Topics: Animals; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histone-Lysine N-Methyltransferase; Humans; Immunoprecipitation; Mass Spectrometry; Methylation; Mice; Neoplasms; Protein Processing, Post-Translational; Real-Time Polymerase Chain Reaction; Ubiquitination | 2015 |
Epigenetic reprogramming in solid tumors: therapeutic implications of EZH2 gain-of-function mutations.
Topics: Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Methylation; Molecular Targeted Therapy; Mutation; Neoplasms; Polycomb Repressive Complex 2 | 2015 |
Development-linked changes in DNA methylation and hydroxymethylation in humans: interview with Dr Melanie Ehrlich.
Topics: 5-Methylcytosine; DNA Methylation; Epigenesis, Genetic; Epigenomics; History, 20th Century; History, 21st Century; Humans; Methylation; Neoplasms; Organ Specificity | 2015 |
Application of Celluclast 1.5L in apple pectin extraction.
Topics: Acetylation; Antineoplastic Agents, Phytogenic; Antioxidants; Biocatalysis; Caco-2 Cells; Cell Movement; Cell Proliferation; Chemical Fractionation; Hexuronic Acids; Humans; Malus; Methylation; Neoplasms; Pectins | 2015 |
Alternative transcription initiation leads to expression of a novel ALK isoform in cancer.
Topics: Alleles; Anaplastic Lymphoma Kinase; Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Histones; Humans; Introns; Isoenzymes; Lysine; Methylation; Mice; Molecular Sequence Data; Molecular Weight; Neoplasms; NIH 3T3 Cells; Oncogenes; Protein Structure, Tertiary; Receptor Protein-Tyrosine Kinases; RNA Polymerase II; RNA, Messenger; Signal Transduction; Transcription Initiation, Genetic | 2015 |
PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP.
Topics: Amino Acid Sequence; Arginine; Cell Line, Tumor; Chromosomal Proteins, Non-Histone; HEK293 Cells; HeLa Cells; Humans; Methylation; Mitosis; Molecular Sequence Data; Neoplasms; Protein-Arginine N-Methyltransferases; Repressor Proteins; Transfection | 2015 |
Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2.
Topics: Allosteric Regulation; Amino Acid Sequence; Catalysis; Catalytic Domain; Chaetomium; Crystallography, X-Ray; Fungal Proteins; Gene Silencing; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Molecular Sequence Data; Mutation; Neoplasms; Polycomb Repressive Complex 2; Protein Structure, Tertiary; S-Adenosylhomocysteine; Transcription, Genetic | 2015 |
LncRNA ontology: inferring lncRNA functions based on chromatin states and expression patterns.
Topics: Algorithms; Cell Line; Cell Line, Tumor; Cells, Cultured; Chromatin; Gene Expression Profiling; Gene Ontology; Gene Regulatory Networks; HeLa Cells; Hep G2 Cells; Histones; Humans; K562 Cells; Lysine; Methylation; Models, Genetic; Neoplasms; Promoter Regions, Genetic; RNA, Long Noncoding; RNA, Messenger; Transcription Initiation Site | 2015 |
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2.
Topics: Acetylation; Animals; Catalysis; Cell Line, Tumor; Chromosomal Proteins, Non-Histone; Drug Resistance, Neoplasm; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Female; Humans; Indoles; Methylation; Mice, Nude; Mutation; Neoplasms; Phosphorylation; Polycomb Repressive Complex 2; Pyridones; RNA, Small Interfering; Transcription Factors; Xenograft Model Antitumor Assays | 2015 |
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice, Inbred BALB C; Mice, Nude; Molecular Sequence Data; Neoplasms; Nuclear Proteins; Nucleotides; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleoside Diphosphate Reductase; RNA Interference; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Xenograft Model Antitumor Assays | 2015 |
Flat SAR of P3-methylsulphonamide based small molecule legumain inhibitors.
Topics: Animals; Cysteine Endopeptidases; Drug Design; Humans; Methylation; Mice; Neoplasms; Protease Inhibitors; Rats; Small Molecule Libraries; Structure-Activity Relationship; Sulfonamides | 2016 |
Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Gene Knock-In Techniques; HEK293 Cells; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Methylation; Mice; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Protein Methyltransferases; Protein Processing, Post-Translational; Protein Stability; Retinal Neovascularization; Retinopathy of Prematurity; Reverse Transcriptase Polymerase Chain Reaction | 2016 |
Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Halogenation; Histone Deacetylase Inhibitors; Humans; Ketones; Methylation; Neoplasms; Structure-Activity Relationship; Thiazoles; Zinc | 2016 |
A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression.
Topics: A549 Cells; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenocarcinoma of Lung; Arginine; Breast Neoplasms; Carcinoma, Squamous Cell; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Lung Neoplasms; MCF-7 Cells; Methylation; Neoplasm Invasiveness; Neoplasms; Prognosis; Protein-Arginine N-Methyltransferases; Sequence Analysis, RNA; Transcription, Genetic; Transforming Growth Factor beta | 2017 |
IDH1, Histone Methylation, and So Forth.
Topics: DNA Methylation; Histones; Humans; Isocitrate Dehydrogenase; Methylation; Mutation; Neoplasms | 2016 |
Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation.
Topics: Enzyme Stability; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Methyltransferases; Mutation; Neoplasm Proteins; Neoplasms; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Structure-Activity Relationship | 2016 |
A New Chromatin-Cytoskeleton Link in Cancer.
Topics: Chromatin; Cytoskeleton; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Tubulin | 2016 |
Nephrotoxicity of epigenetic inhibitors used for the treatment of cancer.
Topics: Acetylation; Animals; Antineoplastic Agents; Azacitidine; Cell Death; Cell Line, Tumor; Cell Proliferation; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Docetaxel; Epigenesis, Genetic; HEK293 Cells; Histones; Humans; Hydroxamic Acids; Kidney; Male; Methylation; Neoplasms; Oligopeptides; Prostatic Neoplasms; Rats; Taxoids | 2016 |
Knockout of arsenic (+3 oxidation state) methyltransferase results in sex-dependent changes in phosphatidylcholine metabolism in mice.
Topics: Animals; Arsenic; Arsenic Poisoning; Arsenites; Biotransformation; Carcinogens, Environmental; Female; Liver; Male; Methylation; Methyltransferases; Mice, Inbred C57BL; Mice, Knockout; Neoplasms; Phosphatidylcholines; Sex Characteristics | 2016 |
Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.
Topics: Animals; DNA Methylation; Glutamine; Histone Demethylases; Histones; Humans; Ketoglutaric Acids; Methylation; Methyltransferases; Neoplasms | 2016 |
SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1.
Topics: Cell Membrane; Enzyme Activation; Gene Expression; Gene Knockdown Techniques; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Neoplasms; Phosphorylation; Pleckstrin Homology Domains; Proto-Oncogene Proteins c-akt; Signal Transduction; Tyrosine | 2016 |
Mechanistic and biological characteristics of different sugar conjugated 2-methyl malonatoplatinum(II) complexes as new tumor targeting agents.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Drug Screening Assays, Antitumor; Glucose Transport Proteins, Facilitative; Glycoconjugates; Humans; Male; Methylation; Mice; Neoplasms; Organoplatinum Compounds; Oxaliplatin | 2017 |
Alteration of histone H3 lysine 9 dimethylation in peripheral white blood cells of septic patients with trauma and cancer.
Topics: Adult; Aged; Aged, 80 and over; C-Reactive Protein; Female; Fluorescent Antibody Technique; Histones; Humans; Leukocytes; Lysine; Male; Methylation; Middle Aged; Neoplasms; ROC Curve; Sepsis; Wounds and Injuries | 2016 |
Unique Triphenylphosphonium Derivatives for Enhanced Mitochondrial Uptake and Photodynamic Therapy.
Topics: Cell Line; Drug Carriers; Fluoresceins; Halogenation; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Methylation; Microscopy, Confocal; Microscopy, Fluorescence; Mitochondria; Neoplasms; Organophosphorus Compounds; Photochemotherapy; Photosensitizing Agents; Thermodynamics | 2017 |
Emerging links between m
Topics: Adenosine; Animals; Humans; Methylation; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Messenger | 2017 |
Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer.
Topics: beta-Transducin Repeat-Containing Proteins; Breast Neoplasms; Cell Line, Tumor; Chromatin Assembly and Disassembly; DNA Helicases; DNA-Binding Proteins; Female; Gene Expression Regulation, Neoplastic; Genes, Essential; Glycogen Synthase Kinase 3 beta; Histones; Humans; Lysine; Male; Methylation; Molecular Targeted Therapy; Neoplasms; NF-kappa B; Phosphorylation; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Protein Stability; Proteolysis; PTEN Phosphohydrolase; Tumor Necrosis Factor-alpha; Ubiquitination | 2017 |
Distribution bias analysis of germline and somatic single-nucleotide variations that impact protein functional site and neighboring amino acids.
Topics: Acetylation; Catalytic Domain; Databases, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Ontology; Germ-Line Mutation; Glycosylation; Humans; Methylation; Molecular Sequence Annotation; Neoplasm Proteins; Neoplasms; Phosphorylation; Polymorphism, Single Nucleotide; Protein Processing, Post-Translational; Survival Analysis; Ubiquitination | 2017 |
Chromatin reader ZMYND8 is a key target of all trans retinoic acid-mediated inhibition of cancer cell proliferation.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Chromatin; Chromatin Immunoprecipitation; Fluorescent Antibody Technique; Histone Deacetylases; Histones; Humans; Lysine; Methylation; Mice; Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic; Receptors for Activated C Kinase; Receptors, Cell Surface; Response Elements; RNA Polymerase II; Time Factors; Tretinoin; Tumor Suppressor Proteins; YY1 Transcription Factor | 2017 |
Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation.
Topics: Crystallography, X-Ray; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Mutant Proteins; Mutation, Missense; Neoplasms; Protein Binding; Protein Conformation; Protein Processing, Post-Translational | 2017 |
Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives.
Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Survival; Drug Design; Drug Screening Assays, Antitumor; Humans; Methylation; Neoplasms; Piperazine; Piperazines; Sulfones | 2017 |
Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor.
Topics: Apoptosis; Crystallography, X-Ray; DNA Repair; Histones; Humans; Inhibitor of Growth Protein 1; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutation; Neoplasms; Nuclear Proteins; Peptides; Protein Array Analysis; Protein Binding; Protein Structure, Tertiary; Tumor Suppressor Proteins | 2008 |
Relationship between the methylation status of dietary flavonoids and their growth-inhibitory and apoptosis-inducing activities in human cancer cells.
Topics: Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Diet; Flavonoids; G1 Phase; Humans; Methylation; Neoplasms; Poly(ADP-ribose) Polymerases; Structure-Activity Relationship | 2008 |
Synthesis and utilization of chiral alpha-methylated alpha-amino acids with a carboxyalkyl side chain in the design of novel Grb2-SH2 peptide inhibitors free of phosphotyrosine.
Topics: Alkylation; Amino Acids; Carboxylic Acids; Cell Line, Tumor; Cell Proliferation; Drug Design; GRB2 Adaptor Protein; Humans; Methylation; Neoplasms; Peptides; Phosphorylation; src Homology Domains; Stereoisomerism; Structure-Activity Relationship | 2008 |
Requirement of RIZ1 for cancer prevention by methyl-balanced diet.
Topics: Animals; Diet; DNA-Binding Proteins; Food; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Methionine; Methylation; Mice; Mice, Knockout; Neoplasms; Nuclear Proteins; S-Adenosylmethionine; Transcription Factors | 2008 |
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer.
Topics: 3' Untranslated Regions; Algorithms; Breast Neoplasms; Cell Line, Tumor; Disease Progression; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genome, Human; Histones; Humans; Lysine; Male; Methylation; MicroRNAs; Neoplasm Metastasis; Neoplasms; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Prostatic Neoplasms; RNA, Small Interfering; Stomach Neoplasms; Transcription Factors | 2008 |
p53 methylation--the Arg-ument is clear.
Topics: Animals; Arginine; DNA Damage; Humans; Methylation; Neoplasms; Phosphorylation; Protein Methyltransferases; Protein Processing, Post-Translational; Tumor Suppressor Protein p53 | 2009 |
Incorporation of 5-chlorocytosine into mammalian DNA results in heritable gene silencing and altered cytosine methylation patterns.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Cytosine; DNA; DNA Damage; DNA Replication; Gene Silencing; Glycine; Humans; Inflammation; Mammals; Methylation; Neoplasms; Oligonucleotides | 2009 |
Macroscopic differences in HMGA oncoproteins post-translational modifications: C-terminal phosphorylation of HMGA2 affects its DNA binding properties.
Topics: Amino Acid Sequence; Cell Line, Tumor; Chromatography, Liquid; HMGA Proteins; HMGA2 Protein; HMGN Proteins; Humans; Mass Spectrometry; Methylation; Molecular Sequence Data; Neoplasms; Phosphorylation; Protein Binding; Protein Interaction Mapping; Protein Processing, Post-Translational; Sequence Alignment; Serine | 2009 |
PRIP promotes tumor formation through enhancing serum-responsive factor-mediated FOS expression.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Mammary Neoplasms, Animal; Methylation; Mice; Mice, Knockout; Neoplasms; Nuclear Receptor Coactivators; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-fos; ras Proteins; Serum Response Factor | 2009 |
DNA methylation and histone modification regulate silencing of OPG during tumor progression.
Topics: Cell Line, Tumor; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Histones; Humans; Male; Methylation; Neoplasms; Osteoprotegerin; Prostatic Neoplasms | 2009 |
Arginine methylation regulates telomere length and stability.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arginine; Cell Line; Cell Proliferation; Cellular Senescence; Chromatin Immunoprecipitation; Humans; Methylation; Molecular Sequence Data; Neoplasms; Protein Binding; Protein Structure, Tertiary; Protein-Arginine N-Methyltransferases; Repressor Proteins; Structure-Activity Relationship; Telomere; Telomeric Repeat Binding Protein 2 | 2009 |
Reprogramming of HeLa cells upon DNMT3L overexpression mimics carcinogenesis.
Topics: Cell Proliferation; Cell Shape; Cellular Reprogramming; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression Regulation, Neoplastic; Genome, Human; HeLa Cells; Histones; Humans; Methylation; Molecular Mimicry; Neoplasms; Pluripotent Stem Cells; Promoter Regions, Genetic; Tumor Stem Cell Assay | 2009 |
Polymorphisms in arsenic metabolism genes, urinary arsenic methylation profile and cancer.
Topics: Arsenic; Arsenic Poisoning; Chromatography, High Pressure Liquid; Female; Genetic Predisposition to Disease; Humans; Incidence; Male; Methylation; Neoplasms; Polymorphism, Single Nucleotide; Taiwan; Water Pollutants, Chemical | 2009 |
Epigenetic information in chromatin and cancer.
Topics: Acetylation; Chromatin; DNA Repair; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms; Transcription, Genetic | 2009 |
A pharmacokinetic and safety study of intravenous arsenic trioxide in adult cancer patients with renal impairment.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Area Under Curve; Arsenic Trioxide; Arsenicals; Biotransformation; Female; Humans; Karnofsky Performance Status; Kidney Diseases; Male; Methylation; Middle Aged; Neoplasms; Oxides | 2010 |
Label-free analysis of DNA methylation using optofluidic ring resonators.
Topics: Animals; Cell Proliferation; Cytosine; DNA Methylation; Epigenesis, Genetic; Equipment Design; Humans; Methylation; Mice; Neoplasms; Nucleic Acid Hybridization; Oligonucleotides; Optics and Photonics | 2009 |
G9a and Glp methylate lysine 373 in the tumor suppressor p53.
Topics: Autoantigens; DNA Damage; DNA Methylation; Gene Expression Regulation; Golgi Matrix Proteins; Histocompatibility Antigens; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Neoplasms; Peptides; Protein Processing, Post-Translational; Proteins; Recombinant Proteins; RNA, Small Interfering; Tumor Suppressor Protein p53 | 2010 |
The histone demethylase UTX enables RB-dependent cell fate control.
Topics: Animals; Caenorhabditis elegans; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Chromatin; Gene Expression Regulation; Genome; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Mice; Neoplasms; Retinoblastoma Binding Proteins | 2010 |
Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity.
Topics: Acetylation; Cell Line, Tumor; Chromatin Assembly and Disassembly; Computational Biology; CpG Islands; Databases, Genetic; DNA Methylation; Down-Regulation; Embryonic Stem Cells; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes; Genome, Human; Histones; Humans; Loss of Heterozygosity; Male; Methylation; MicroRNAs; Multigene Family; Neoplasms; Promoter Regions, Genetic; Prostatic Neoplasms; RNA, Messenger; Transcription, Genetic; Up-Regulation | 2010 |
Close encounters: RIDGEs, hyperacetylated chromatin, radiation breakpoints and genes differentially expressed in tumors cluster at specific human chromosome regions.
Topics: Animals; Chromatin; Chromosomes, Human; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms | 2010 |
Hypoxia-inducible factor (HIF)-3alpha is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2.
Topics: Alternative Splicing; Apoptosis Regulatory Proteins; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1; Methylation; Mutant Proteins; Neoplasms; Repressor Proteins; RNA, Messenger; Transcription Initiation Site; Transcription, Genetic | 2010 |
Tumor suppression by the histone demethylase UTX.
Topics: Animals; Drosophila; Drosophila Proteins; G1 Phase; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Neoplasms; Nuclear Proteins; Oxidoreductases, N-Demethylating; Retinoblastoma Binding Proteins; Retinoblastoma Protein; S Phase | 2010 |
Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Cell Cycle; Chromatin; Cyclin E; Gene Expression Regulation; Gene Knockout Techniques; Growth and Development; HeLa Cells; Histones; Humans; Longevity; Lymphopoiesis; Lysine; Male; Methylation; Mice; Molecular Sequence Data; Neoplasms; Nuclear Proteins; Repressor Proteins; Survival Rate; Tumor Suppressor Proteins | 2010 |
Negative regulation of hypoxic responses via induced Reptin methylation.
Topics: Animals; ATPases Associated with Diverse Cellular Activities; Carrier Proteins; Cell Hypoxia; Cell Line; DNA Helicases; Female; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysine; Methylation; Mice; Models, Biological; Neoplasms; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Protein Binding; Xenograft Model Antitumor Assays | 2010 |
Replication stress, a source of epigenetic aberrations in cancer?
Topics: Chromatin; Chromosome Aberrations; DNA Replication; Epigenesis, Genetic; Epigenomics; Histones; Methylation; Neoplasms; Nuclear Proteins | 2010 |
Heterochromatin silencing of p53 target genes by a small viral protein.
Topics: Adenoviridae; Cell Proliferation; Cells, Cultured; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; HCT116 Cells; Heterochromatin; Histones; Humans; Methylation; Neoplasms; Oncogene Proteins, Viral; Protein Binding; Tumor Suppressor Protein p53; Virus Replication | 2010 |
Carboxymethylated polyvinyl alcohol stabilizes doped ferrofluids for biological applications.
Topics: Cell Line, Tumor; Ferric Compounds; Humans; Hydrogen-Ion Concentration; Magnetics; Manganese Compounds; Methylation; Nanoparticles; Nanotechnology; Neoplasms; Osmolar Concentration; Polyvinyl Alcohol; Temperature | 2010 |
The influence of methylation on carcinogenic activity; N-methyl-3 : 4 : 5 : 6-dibenzcarbazole.
Topics: Carcinogens; Humans; Methylation; Neoplasms | 1946 |
Multi-cancer computational analysis reveals invasion-associated variant of desmoplastic reaction involving INHBA, THBS2 and COL11A1.
Topics: Collagen Type XI; Computational Biology; Fibroblasts; Humans; Inhibin-beta Subunits; Methylation; MicroRNAs; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Neoplasms; Thrombospondins; Treatment Outcome | 2010 |
Immunohistochemical detection of arginine methylated proteins (MeRP) in archival tissues.
Topics: Antibodies; Antibody Specificity; Arginine; Immunohistochemistry; Methylation; Neoplasms; Paraffin Embedding; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Proteins | 2010 |
Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells.
Topics: Animals; Cell Cycle; Histone Demethylases; Humans; Methylation; Mice; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Neoplasms; Oxidoreductases, N-Demethylating; Retinoblastoma Protein | 2011 |
Lysine methylation of promoter-bound transcription factors and relevance to cancer.
Topics: DNA; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Neoplasms; NF-kappa B; Promoter Regions, Genetic; STAT3 Transcription Factor | 2011 |
Down-regulation of the tumor suppressor C-terminal Src kinase (Csk)-binding protein (Cbp)/PAG1 is mediated by epigenetic histone modifications via the mitogen-activated protein kinase (MAPK)/phosphatidylinositol 3-kinase (PI3K) pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Transformation, Neoplastic; Embryo, Mammalian; Epigenesis, Genetic; Fibroblasts; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histones; Humans; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Membrane Proteins; Methylation; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoproteins; Protein Processing, Post-Translational; Proto-Oncogene Proteins pp60(c-src); ras Proteins; Tumor Suppressor Proteins | 2011 |
Radiosynthesis of [11C]Vandetanib and [11C]chloro-Vandetanib as new potential PET agents for imaging of VEGFR in cancer.
Topics: Carbon Radioisotopes; Chlorine; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Methylation; Molecular Structure; Neoplasms; Piperidines; Positron-Emission Tomography; Quinazolines; Radiopharmaceuticals; Receptors, Vascular Endothelial Growth Factor | 2011 |
Homeobox gene Rhox5 is regulated by epigenetic mechanisms in cancer and stem cells and promotes cancer growth.
Topics: Animals; Benzamides; Cell Differentiation; Cell Line, Tumor; Cell Movement; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Homeodomain Proteins; Humans; Methylation; Mice; Mice, Nude; Neoplasms; Promoter Regions, Genetic; Pyridines; RNA, Messenger; Stem Cells; Transcription Factors; Tretinoin; Tumor Burden; Xenograft Model Antitumor Assays | 2011 |
Synthesis and biological evaluation of the 12,12-dimethyl derivative of Aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin.
Topics: Anticarcinogenic Agents; Antigens, Viral; B-Lymphocytes; Carcinogens; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Epstein-Barr Virus Infections; Furans; Herpesvirus 4, Human; Humans; Hydrophobic and Hydrophilic Interactions; Lyngbya Toxins; Methylation; Neoplasms; Phorbol Esters; Protein Binding; Protein Kinase C-delta; Spiro Compounds; Structure-Activity Relationship | 2011 |
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.
Topics: Animals; Enzyme Inhibitors; Epigenomics; Histone Demethylases; Histones; Methylation; Mice; Mice, Knockout; Neoplasms; Proto-Oncogene Proteins; Retinoblastoma Protein; Retinol-Binding Proteins, Cellular; Survival Rate | 2011 |
Novel positron emission tomography tracer distinguishes normal from cancerous cells.
Topics: Cell Division; Cell Line, Tumor; Deoxyuracil Nucleotides; DNA Replication; DNA, Neoplasm; Humans; Methylation; Neoplasm Proteins; Neoplasms; Positron-Emission Tomography; Radioactive Tracers; Radiography; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 2011 |
Structure of human SMYD2 protein reveals the basis of p53 tumor suppressor methylation.
Topics: Calorimetry; Cell Line, Tumor; Crystallography, X-Ray; Genes, Tumor Suppressor; Histone-Lysine N-Methyltransferase; Histones; Humans; Kinetics; Lysine; Methylation; Molecular Conformation; Neoplasms; Protein Binding; Transcription, Genetic; Tumor Suppressor Protein p53 | 2011 |
Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Embryonic Stem Cells; Epigenomics; HEK293 Cells; HeLa Cells; Histone Demethylases; Histones; Humans; Methylation; Mice; Neoplasms; NIH 3T3 Cells; Octamer Transcription Factor-3; Pluripotent Stem Cells; RNA Interference; Sensitivity and Specificity; SOXB1 Transcription Factors | 2011 |
Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway.
Topics: beta Catenin; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HCT116 Cells; HEK293 Cells; Hep G2 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunohistochemistry; Lung Neoplasms; Methylation; Neoplasms; Oligonucleotide Array Sequence Analysis; Protein Binding; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tissue Array Analysis; Urinary Bladder Neoplasms; Wnt Signaling Pathway | 2011 |
SMYD3 promotes cancer invasion by epigenetic upregulation of the metalloproteinase MMP-9.
Topics: Animals; Blotting, Western; Cattle; Cell Line, Tumor; Cell Proliferation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Host-Parasite Interactions; Humans; Matrix Metalloproteinase 9; Methylation; Neoplasm Invasiveness; Neoplasm Transplantation; Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Theileria; Theileriasis; Transplantation, Heterologous; Up-Regulation; Zebrafish | 2012 |
Genetic discoveries propagate new epigenetic drugs.
Topics: Animals; Antineoplastic Agents; Epigenesis, Genetic; Histones; Humans; Methylation; Mutation; Neoplasms | 2012 |
Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo.
Topics: Animals; Biological Availability; Catechin; Catechol O-Methyltransferase; Cell Line, Tumor; Down-Regulation; Humans; Male; Methylation; Mice; Mice, SCID; Neoplasms; Polyphenols; Quercetin; Tea; Up-Regulation | 2012 |
Computational identification and modeling of crosstalk between phosphorylation, O-β-glycosylation and methylation of FoxO3 and implications for cancer therapeutics.
Topics: Amino Acid Sequence; Forkhead Box Protein O3; Forkhead Transcription Factors; Glycosylation; Humans; Methylation; Models, Molecular; Molecular Sequence Data; Neoplasms; Phosphorylation; Phosphotyrosine; Protein Kinases | 2012 |
Relevance of histone marks H3K9me3 and H4K20me3 in cancer.
Topics: Acetyltransferases; Adult; Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; CA-19-9 Antigen; Carcinoembryonic Antigen; Female; Histones; Humans; Male; Methylation; Middle Aged; Neoplasms; Nucleosomes | 2012 |
Molecular biology. Genetic events that shape the cancer epigenome.
Topics: Chromatin; DNA Methylation; Enhancer Elements, Genetic; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genome, Human; Histones; Humans; Methylation; Mutation; Neoplasms; Promoter Regions, Genetic; Transcription Factors; Transcription, Genetic | 2012 |
Chromatin organization is a major influence on regional mutation rates in human cancer cells.
Topics: Animals; CpG Islands; Epigenesis, Genetic; Euchromatin; Genome, Human; Heterochromatin; Histones; Humans; Leukemia; Lung Neoplasms; Male; Melanoma; Methylation; Mutagenesis; Mutation Rate; Neoplasms; Pan troglodytes; Polymorphism, Single Nucleotide; Principal Component Analysis; Prostatic Neoplasms; Small Cell Lung Carcinoma | 2012 |
T-ARG-eting E2F-1 growth control.
Topics: Animals; Apoptosis; Arginine; E2F1 Transcription Factor; Gene Expression Regulation, Neoplastic; Methylation; Mice; Neoplasms; Protein Methyltransferases; Protein-Arginine N-Methyltransferases; Tumor Suppressor Protein p53; Ubiquitination | 2012 |
Induction of aberrant trimethylation of histone H3 lysine 27 by inflammation in mouse colonic epithelial cells.
Topics: Aging; Animals; Apoptosis Regulatory Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Colitis; Colon; Death-Associated Protein Kinases; Dextran Sulfate; Epithelial Cells; Gene Expression; Histones; Intestinal Mucosa; Lysine; Male; Methylation; Mice; Mice, Inbred BALB C; Neoplasms | 2012 |
TreeVis: a MATLAB-based tool for tree visualization.
Topics: Algorithms; Cell Line, Tumor; Computational Biology; Computer Graphics; Genome, Human; Humans; Methylation; Neoplasms; Software; User-Computer Interface | 2013 |
Human RNA methyltransferase BCDIN3D regulates microRNA processing.
Topics: Cell Line, Tumor; DEAD-box RNA Helicases; Humans; MCF-7 Cells; Methylation; Methyltransferases; MicroRNAs; Neoplasms; Ribonuclease III; RNA Processing, Post-Transcriptional | 2012 |
Chd5 requires PHD-mediated histone 3 binding for tumor suppression.
Topics: Amino Acid Sequence; Animals; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; DNA Helicases; Genetic Loci; Genome; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Mice; Models, Molecular; Molecular Sequence Data; Mutation; Neoplasms; Neuroblastoma; Peptides; Protein Binding; Structure-Activity Relationship | 2013 |
Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells.
Topics: Acetylation; Cadherins; Chromatin; Chromosomal Proteins, Non-Histone; CpG Islands; DNA Methylation; DNA-Binding Proteins; Gene Silencing; Histones; Humans; Lysine; Methyl-CpG-Binding Protein 2; Methylation; Neoplasms; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; Tumor Cells, Cultured | 2002 |
NSD1 is essential for early post-implantation development and has a catalytically active SET domain.
Topics: Amino Acid Sequence; Animals; Apoptosis; Carrier Proteins; Chromosomes, Human, Pair 5; Embryo, Mammalian; Embryonic Development; Female; Gene Targeting; Genes, Reporter; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; In Situ Hybridization; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Male; Mesoderm; Methylation; Methyltransferases; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Neoplasms; Nuclear Proteins; Pregnancy; Protein Methyltransferases; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Alignment | 2003 |
METHYLATION OF RIBONUCLEIC ACIDS OF LIVER AND OTHER ORGANS IN DIFFERENT SPECIES TREATED WITH C14- AND H3-DIMETHYLNITROSAMINES IN VIVO.
Topics: Animals; Carbon Isotopes; Carcinogens; Chemical and Drug Induced Liver Injury; Chromatography; Cricetinae; Dimethylnitrosamine; Guanine; Guinea Pigs; Hepatitis; Kidney; Liver; Methylation; Mice; Neoplasms; Nitrosamines; Nucleotides; Proteins; Pyrimidines; Rats; Research; RNA; Spleen; Toxicology; Tritium | 1964 |
METHYLATION OF LIVER DNA IN THE INTACT ANIMAL BY THE CARCINOGEN DIMETHYLNITROSAMINE DURING CARCINOGENESIS.
Topics: Alkylation; Animals; Carbon Isotopes; Carcinogenesis; Carcinogens; Diet; Dimethylnitrosamine; DNA; Liver; Metabolism; Methylation; Neoplasms; Nitrosamines; Rats; Research | 1965 |
Fighting cancer by disrupting C-terminal methylation of signaling proteins.
Topics: Animals; Methylation; Neoplasms; Protein Methyltransferases; Protein Prenylation; Proteins; ras Proteins; Signal Transduction | 2004 |
Three dimensional analysis of histone methylation patterns in normal and tumor cell nuclei.
Topics: Cell Line, Tumor; Cell Nucleus; Centromere; DNA; Female; Fibroblasts; Heterochromatin; Histones; Humans; Lysine; Methylation; Monocytes; Neoplasms; T-Lymphocytes | 2004 |
Arginine methylation of STAT1: a reassessment.
Topics: Arginine; Artifacts; DNA-Binding Proteins; Humans; Interferons; Methylation; Methyltransferases; Mutation; Neoplasms; Reproducibility of Results; STAT1 Transcription Factor; Trans-Activators | 2004 |
Epigenotyping as a tool for the prediction of tumor risk and tumor type in patients with Beckwith-Wiedemann syndrome (BWS).
Topics: Beckwith-Wiedemann Syndrome; Child, Preschool; France; Genes, Wilms Tumor; Genotype; Humans; Incidence; Kidney Neoplasms; Membrane Proteins; Methylation; Neoplasms; Netherlands; Potassium Channels, Voltage-Gated; Predictive Value of Tests; Risk Factors; Wilms Tumor | 2004 |
Urinary trivalent methylated arsenic species in a population chronically exposed to inorganic arsenic.
Topics: Adolescent; Adult; Arsenic Poisoning; Arsenicals; Cacodylic Acid; Cross-Sectional Studies; Environmental Exposure; Female; Humans; Male; Methylation; Mexico; Middle Aged; Neoplasms; Risk Assessment; Water Supply | 2005 |
Trimethylated chitosans as non-viral gene delivery vectors: cytotoxicity and transfection efficiency.
Topics: Animals; Cell Line, Tumor; Cell Survival; Chitosan; Chlorocebus aethiops; COS Cells; DNA; Dose-Response Relationship, Drug; Excipients; Female; Gene Transfer Techniques; Genes, Reporter; Humans; Luciferases; Methylation; Neoplasms; Transfection | 2005 |
Developmental biology. Combing over the Polycomb group proteins.
Topics: Animals; Chromatin; DNA-Directed RNA Polymerases; Dosage Compensation, Genetic; Drosophila; Drosophila Proteins; Gene Expression Regulation, Developmental; Gene Silencing; Histones; Humans; Male; Methylation; Mutation; Neoplasms; Nucleosomes; Pluripotent Stem Cells; Polycomb Repressive Complex 1; Polycomb-Group Proteins; Prostatic Neoplasms; Proteins; Repressor Proteins; Transcription, Genetic; Ubiquitin | 2005 |
Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives.
Topics: Cell Line, Tumor; Cell Proliferation; Flavones; Flavonoids; Humans; Isoflavones; Methylation; Molecular Structure; Neoplasms; Oximes; Platelet Aggregation; Structure-Activity Relationship | 2005 |
Patterns of global DNA and histone methylation appear to be similar in normal, dysplastic and neoplastic oral epithelium of humans.
Topics: Aged; Antibodies, Monoclonal; Carcinoma, Squamous Cell; Case-Control Studies; DNA; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Epithelium; Gene Silencing; Histones; Humans; Immunohistochemistry; Male; Methylation; Middle Aged; Mouth Neoplasms; Neoplasms | 2005 |
G3139 and other CpG-containing immunostimulatory phosphorothioate oligodeoxynucleotides are potent suppressors of the growth of human tumor xenografts in nude mice.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Antineoplastic Agents; B-Lymphocytes; Carcinoma; Cell Line, Tumor; Cytosine; Female; Humans; Lung Neoplasms; Lymphocyte Activation; Methylation; Mice; Mice, Nude; Neoplasms; Oligodeoxyribonucleotides; Ovarian Neoplasms; Proto-Oncogene Proteins c-bcl-2; Thionucleotides; Xenograft Model Antitumor Assays | 2006 |
Biological evaluation of bishydroxymethyl-substituted cage dimeric 1,4-dihydropyridines as a novel class of p-glycoprotein modulating agents in cancer cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Proliferation; Dihydropyridines; Dimerization; Hydroxylation; Methylation; Mice; Molecular Structure; Neoplasms; Structure-Activity Relationship | 2006 |
The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Carcinoma, Squamous Cell; Cell Cycle; Cell Nucleolus; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; Mice; Mice, Nude; Mice, Transgenic; Molecular Sequence Data; Multigene Family; Neoplasms; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc; RNA; RNA Interference; RNA Polymerase III; Transcription, Genetic; Transplantation, Heterologous; Up-Regulation | 2006 |
DNA mismatch repair as an effector for promoting phorbol ester-induced apoptotic DNA damage and cell killing: implications in tumor promotion.
Topics: Apoptosis; Azacitidine; Base Pair Mismatch; Cell Line, Tumor; CpG Islands; Decitabine; DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; Humans; Methylation; Neoplasms; Phorbol Esters; Protein Kinase C; Protein Kinase Inhibitors; Reactive Oxygen Species | 2006 |
[Cancer epigenetics].
Topics: Animals; Chromatin Assembly and Disassembly; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; MicroRNAs; Neoplasms | 2006 |
Can the state of cancer chemotherapy resistance be reverted by epigenetic therapy?
Topics: Acetylation; Animals; Antineoplastic Agents; Chromatin; DNA Methylation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Models, Theoretical; Neoplasms | 2006 |
Urinary arsenic methylation and porphyrin profile of C57Bl/6J mice chronically exposed to sodium arsenate.
Topics: Animals; Arsenates; Arsenic; Biomarkers; Carcinogens; Female; Methylation; Mice; Mice, Inbred C57BL; Neoplasms; Porphyrins | 2007 |
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer.
Topics: Caco-2 Cells; Carrier Proteins; Cells, Cultured; Colonic Neoplasms; CpG Islands; DNA Methylation; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms; Viral Envelope Proteins | 2007 |
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.
Topics: Animals; Cell Line; Cellular Senescence; Chromatin Immunoprecipitation; Cyclin-Dependent Kinase Inhibitor p16; DNA-Binding Proteins; Down-Regulation; Embryo, Mammalian; Enhancer of Zeste Homolog 2 Protein; Fibroblasts; Genes, p16; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Mice; Mice, Inbred C57BL; Neoplasms; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Proteins; Proto-Oncogene Proteins; Repressor Proteins; Stem Cells; Transcription Factors; Tumor Suppressor Protein p14ARF | 2007 |
Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.
Topics: Calcium; Cell Line, Tumor; Chromosomes, Human, Pair 12; CpG Islands; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Methylation; Neoplasms; Phenotype; ras GTPase-Activating Proteins; ras Proteins | 2007 |
It takes a village to develop biomarkers.
Topics: Biomarkers, Tumor; Humans; Methylation; Neoplasms; Proteins; Proteomics; Research; United States | 2007 |
Differentially expressed genes are marked by histone 3 lysine 9 trimethylation in human cancer cells.
Topics: Cell Line, Tumor; DNA Methylation; Gene Expression Regulation, Neoplastic; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Myeloid Ecotropic Viral Integration Site 1 Protein; Neoplasm Proteins; Neoplasms; Otx Transcription Factors; Transcription, Genetic | 2008 |
Carcinogenesis and the hypothesis of phylogenetic reversion.
Topics: Animals; Cell Transformation, Neoplastic; Chemoprevention; CpG Islands; Gene Silencing; Humans; Karyometry; Methylation; Neoplasms; Phylogeny | 2007 |
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.
Topics: Benzenesulfonamides; Binding Sites; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cytosol; Humans; Hydrocarbons, Chlorinated; Isoenzymes; Methylation; Models, Molecular; Molecular Sequence Data; Molecular Structure; Neoplasms; Protein Folding; Sequence Alignment; Structure-Activity Relationship; Sulfhydryl Compounds; Sulfonamides | 2008 |
COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro.
Topics: Celecoxib; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Humans; Immunoblotting; Methylation; Neoplasms; Pyrazoles; Sulfonamides; Transcription Factor CHOP | 2008 |
Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: XII mutational and non-mutational mechanism as subsets of a more general mechanism. Part A--Ethionine.
Topics: alpha-Fetoproteins; Animals; Carcinogens; DNA, Neoplasm; Embryo, Mammalian; Ethionine; Gene Expression Regulation; Humans; Methylation; Neoplasm Proteins; Neoplasms; S-Adenosylmethionine | 1984 |
Hypomethylation of DNA in human cancer cells: a site-specific change in the c-myc oncogene.
Topics: Base Sequence; Cell Line; DNA Restriction Enzymes; DNA, Neoplasm; Glioma; Humans; Lung Neoplasms; Melanoma; Methylation; Neoplasms; Oncogenes | 1984 |
Hypomethylation distinguishes genes of some human cancers from their normal counterparts.
Topics: Aged; Base Sequence; Colonic Neoplasms; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA Restriction Enzymes; Female; Genes; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Neoplasms | 1983 |
Hypomethylation of ras oncogenes in primary human cancers.
Topics: Adenocarcinoma; Carcinoma, Small Cell; Colonic Neoplasms; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA Restriction Enzymes; DNA, Neoplasm; Humans; Lung Neoplasms; Methylation; Neoplasms; Nucleic Acid Hybridization; Oncogenes; Polymorphism, Genetic | 1983 |
Multivariate analysis of urinary RNA catabolites in malignancies: cross-sectional and longitudinal studies.
Topics: Analysis of Variance; Autoanalysis; Breast Neoplasms; Female; Humans; Kidney Neoplasms; Longitudinal Studies; Lung Neoplasms; Lymphoma; Male; Methylation; Neoplasms; Prostatic Neoplasms; Ribonucleosides; RNA | 1983 |
Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains.
Topics: Adenoviruses, Human; Cells, Cultured; DNA Repair; Guanine; Humans; Methylation; Methylnitronitrosoguanidine; Neoplasms; Simian virus 40; Sister Chromatid Exchange | 1980 |
The 5-methylcytosine content of DNA from human tumors.
Topics: 5-Methylcytosine; Brain Chemistry; Cytosine; DNA; DNA Restriction Enzymes; DNA, Neoplasm; Female; Humans; Methylation; Neoplasms; Placenta; Pregnancy; Structure-Activity Relationship | 1983 |
Effect of 2'-O-methylation on the structure of mammalian 5.8S rRNAs and the 5.8S-28S rRNA junction.
Topics: Animals; Base Sequence; Cell Line; Cricetinae; Cricetulus; Female; Liver; Methylation; Molecular Weight; Neoplasms; Nucleic Acid Conformation; Nucleic Acid Denaturation; Ovary; Pancreas; Rats; Ribonuclease T1; RNA, Ribosomal | 1983 |
Ethanol and dimethylnitrosamine and diethylnitrosamine metabolism and disposition in the rat. Possible relevance to the influence of ethanol on human cancer incidence.
Topics: Alkylation; Animals; Carbon Dioxide; Dimethylnitrosamine; DNA; Drug Interactions; Esophageal Neoplasms; Esophagus; Ethanol; Female; Humans; Methylation; Neoplasms; Rats; Rats, Inbred Strains | 1984 |
Toward a universal tumour marker.
Topics: Amino Acids; Asbestosis; Chorionic Gonadotropin; DNA, Neoplasm; Female; Humans; Hydatidiform Mole; Lung Neoplasms; Mesothelioma; Methylation; Neoplasm Proteins; Neoplasms; Nucleosides; Pregnancy; RNA, Neoplasm; RNA, Transfer; Uterine Neoplasms | 1984 |
DNA methylation by N-nitrosomethylbenzylamine in target and non-target tissues of laboratory rodents. Comparison with carcinogenicity.
Topics: Animals; Dimethylnitrosamine; DNA; DNA, Neoplasm; Female; Inactivation, Metabolic; Male; Methylation; Mice; Neoplasms; Organ Specificity; Rats; Rats, Inbred Strains | 1984 |
Expression of cellular oncogenes in human malignancies.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinogens; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Female; Gastrointestinal Neoplasms; Gene Amplification; Genes, Viral; Genital Neoplasms, Female; Humans; Kidney Neoplasms; Leukemia; Lymphoma; Methylation; Mutation; Neoplasms; Nucleic Acid Hybridization; Oncogenes; RNA, Messenger; RNA, Neoplasm; Sarcoma; Transcription, Genetic; Translocation, Genetic | 1984 |
Extent of DNA methylation in human tumor cells.
Topics: 5-Methylcytosine; Base Composition; Cell Line; Chromatography, High Pressure Liquid; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; Gene Expression Regulation; Humans; Methylation; Methyltransferases; Neoplasms | 1983 |
Importance of non-genetic mechanisms in carcinogenicity.
Topics: Animals; Biphenyl Compounds; DNA; DNA Repair; DNA Replication; Humans; Kinetics; Male; Methylation; Neoplasms; Oncogenes; Oxygen; Rats; Urinary Bladder Neoplasms | 1983 |
Comparison of repair of O6-methylguanine produced by N-methyl-N'-nitro-N-nitrosoguanidine in mouse and human cells.
Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; DNA Repair; Embryo, Mammalian; Female; Guanine; Humans; Kinetics; Methylation; Methylnitronitrosoguanidine; Mice; Mice, Inbred Strains; Neoplasms; Neoplasms, Experimental; Species Specificity | 1984 |
Methylation of the O6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Guanine; Humans; Liver; Methylation; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Pyrimidines; Structure-Activity Relationship | 1984 |
tRNA alterations in cancer.
Topics: Animals; Base Sequence; Female; Humans; Liver; Liver Neoplasms, Experimental; Methylation; Neoplasms; Nucleic Acid Conformation; Placenta; Pregnancy; Rats; Ribonucleosides; RNA, Neoplasm; RNA, Transfer | 1983 |
New applications of urinary nucleoside markers.
Topics: Adult; Aging; Burkitt Lymphoma; Child; Child, Preschool; Female; Humans; Infant; Male; Methylation; Neoplasms; Nucleosides; Reference Values; RNA, Neoplasm; RNA, Transfer; Sex Factors | 1983 |
Theoretical mechanism for synthesis of carcinogen induced embryonic proteins: VIII. Transcriptional theory.
Topics: Animals; Carcinoembryonic Antigen; Chromatin; DNA; Gene Expression Regulation; Heterochromatin; Humans; Methylation; Neoplasms; Phenotype; Transcription, Genetic | 1982 |
Arsenic risk assessment.
Topics: Arsenic; Bias; Carcinogens, Environmental; Decontamination; Dose-Response Relationship, Drug; Environmental Exposure; Environmental Monitoring; Epidemiological Monitoring; Humans; Linear Models; Methylation; Neoplasms; Nutritional Status; Risk Assessment; Taiwan; United States; United States Environmental Protection Agency; Water Pollutants, Chemical | 1994 |
A cytosine methyltransferase converts 5-methylcytosine in DNA to thymine.
Topics: 5-Methylcytosine; Cytosine; DNA; DNA-Cytosine Methylases; Escherichia coli; Humans; Methylation; Molecular Structure; Mutagenesis; Neoplasms; S-Adenosylhomocysteine; S-Adenosylmethionine; Thymine | 1995 |
Methylation and p16: suppressing the suppressor.
Topics: 5-Methylcytosine; Carrier Proteins; Cell Transformation, Neoplastic; Cocarcinogenesis; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Cytosine; DNA; Gene Expression Regulation; Genes, Tumor Suppressor; Genomic Imprinting; Humans; Methylation; Models, Genetic; Neoplasms | 1995 |
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.
Topics: 5-Methylcytosine; Alleles; Azacitidine; Base Sequence; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carrier Proteins; Chromosomes, Human, Pair 9; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Cytosine; Decitabine; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Glioma; Head and Neck Neoplasms; Humans; Lung Neoplasms; Methylation; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Sequence Deletion; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers.
Topics: Base Sequence; Codon; Genes, p53; Humans; Methylation; Molecular Sequence Data; Mutation; Neoplasms; Oligonucleotides; Organ Specificity; Polymerase Chain Reaction | 1995 |
Demethylation of a repetitive DNA sequence in human cancers.
Topics: Base Sequence; Blotting, Southern; Cloning, Molecular; Colonic Neoplasms; Deoxyribonucleases, Type II Site-Specific; DNA, Neoplasm; Electrophoresis; Female; Genetic Techniques; Humans; Melanoma; Methylation; Molecular Sequence Data; Neoplasms; Pancreatic Neoplasms; Placenta; Pregnancy; Repetitive Sequences, Nucleic Acid; Tumor Cells, Cultured | 1995 |
Hypomethylation of DNA: a possible nongenotoxic mechanism underlying the role of cell proliferation in carcinogenesis.
Topics: 5-Methylcytosine; Animals; Cell Division; Cytosine; DNA; Female; Liver Neoplasms, Experimental; Male; Methylation; Mice; Neoplasms; Proto-Oncogenes | 1993 |
Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer.
Topics: Base Sequence; Blotting, Southern; Bone Neoplasms; Carcinoma, Transitional Cell; Cell Line; Codon; Dinucleoside Phosphates; DNA; DNA, Neoplasm; Fetus; Genes, p53; Humans; Introns; Lymphocytes; Male; Methylation; Molecular Sequence Data; Muscles; Neoplasms; Osteosarcoma; Point Mutation; Polymerase Chain Reaction; Spermatozoa; Transfection; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1994 |
[Parent imprinting: methylation-epigenetic heredity].
Topics: Chromosome Aberrations; Chromosome Disorders; Female; Gene Expression Regulation; Genes; Genetic Diseases, Inborn; Humans; Male; Methylation; Neoplasms | 1993 |
Genomic imprinting and gene activation in cancer.
Topics: Alleles; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Methylation; Models, Genetic; Neoplasms; Neoplastic Syndromes, Hereditary; Oncogenes; Philadelphia Chromosome; Transcriptional Activation | 1993 |
Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains.
Topics: Amino Acid Sequence; Animals; Blood; CHO Cells; Cloning, Molecular; Cricetinae; DNA; DNA Repair; Drug Resistance; HeLa Cells; Humans; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Molecular Sequence Data; Mutagens; Neoplasms; Nucleic Acid Hybridization; Phenotype; Sequence Homology, Amino Acid; Transfection | 1993 |
The role of DNA methylation in the expression of parathyroid hormone-related protein in humoral hypercalcaemia of malignancy.
Topics: DNA, Neoplasm; Gene Expression; Humans; Hypercalcemia; Methylation; Neoplasms; Parathyroid Hormone-Related Protein; Proteins | 1993 |
Genes, chromosomes and cancer. First meeting of the "Arbeitsgemeinschaft Molekular- und Zytogenetik (AEK)" of the Deutsche Krebsgesellschaft.
Topics: Animals; Chromosome Aberrations; Humans; Methylation; Neoplasm Metastasis; Neoplasms; Oncogenes; Recombination, Genetic; Virus Integration | 1993 |
Developmental regulation of myeloid gene expression and demethylation during ex vivo culture of peripheral blood progenitor cells.
Topics: Antigens, CD34; Biomarkers; Cell Differentiation; Cells, Cultured; DNA; DNA (Cytosine-5-)-Methyltransferases; Gene Expression Regulation, Developmental; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Interleukins; Methylation; Muramidase; Neoplasms; Peroxidase; Recombinant Proteins; Stem Cell Factor | 1996 |
Hypomethylation of DNA: a nongenotoxic mechanism involved in tumor promotion.
Topics: Animals; Base Sequence; DNA; Genes, ras; Humans; Methylation; Mice; Molecular Sequence Data; Neoplasms; Risk Assessment | 1995 |
The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Azacitidine; Base Sequence; Decitabine; Dinucleoside Phosphates; DNA; DNA Modification Methylases; DNA Primers; DNA Probes; DNA, Neoplasm; Enzyme Inhibitors; Genome, Human; Humans; Male; Melanoma; Melanoma-Specific Antigens; Methylation; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; T-Lymphocytes, Cytotoxic; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Issues in arsenic cancer risk assessment.
Topics: Arsenic; Dose-Response Relationship, Drug; Food Contamination; Humans; Methylation; Neoplasms; Protein Deficiency; Risk; Taiwan; Water Pollutants, Chemical | 1996 |
Toxicologists shed new light on old poisons.
Topics: Animals; Arsenicals; Carcinogens; Female; Humans; Malaria; Male; Mercury; Methylation; Neoplasms; Toxicology | 1998 |
Arsenic-laced water in Chile.
Topics: Arsenic; Case-Control Studies; Chile; Humans; Lung Neoplasms; Methylation; Neoplasms; Risk Factors; Urinary Bladder Neoplasms; Water Pollutants, Chemical | 1998 |
Suicide prodrugs activated by thymidylate synthase: rationale for treatment and noninvasive imaging of tumors with deoxyuridine analogues.
Topics: Animals; Arabinofuranosyluracil; Cell Division; DNA; Floxuridine; Fluorine Radioisotopes; Humans; Methylation; Mice; Neoplasms; Phosphorylation; Prodrugs; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
BRCA1 and E-cadherin promoter hypermethylation and gene inactivation in cancer-association or mechanism?
Topics: Breast Neoplasms; Cadherins; Female; Gene Expression Regulation, Neoplastic; Genes, BRCA1; Humans; Loss of Heterozygosity; Methylation; Mutation; Neoplasms; Ovarian Neoplasms; Promoter Regions, Genetic; Stomach Neoplasms | 2000 |
Aberrant methylation of gene promoters in cancer---concepts, misconcepts, and promise.
Topics: Animals; Biomarkers, Tumor; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Methylation; Neoplasms; Promoter Regions, Genetic; Up-Regulation | 2000 |
Arsenic species that cause release of iron from ferritin and generation of activated oxygen.
Topics: Animals; Arsenates; Arsenic; Arsenicals; Arsenites; Cacodylic Acid; Carcinogens; Cattle; Ferritins; Glutathione; Horses; Humans; In Vitro Techniques; Iron; Kinetics; Methylation; Neoplasms; Reactive Oxygen Species | 2000 |
Behind the scenes of gene expression.
Topics: Acetylation; Animals; Chromatin; DNA Methylation; Female; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Developmental; Genes, Tumor Suppressor; Genomic Imprinting; Histones; Humans; Male; Methylation; Multigene Family; Neoplasms | 2001 |
Association of blood arsenic levels with increased reactive oxidants and decreased antioxidant capacity in a human population of northeastern Taiwan.
Topics: Adult; Aged; Antioxidants; Arsenic; Arteriosclerosis; Environmental Pollutants; Female; Humans; Male; Methylation; Middle Aged; Neoplasms; Oxidative Stress; Reactive Oxygen Species; Taiwan | 2001 |
A dysmethylation syndrome, bound to folates and/or vitamin B12 and/or methionine abnormalities? Diagnosis, prevention and treatment considerations.
Topics: DNA Methylation; Folic Acid Deficiency; Hematologic Diseases; Humans; Hyperhomocysteinemia; Iatrogenic Disease; Methionine; Methylation; Neoplasms; Nervous System Diseases; Selenium; Vascular Diseases; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 2001 |
Molecular analysis of cancer. An overview.
Topics: Humans; In Situ Hybridization, Fluorescence; Methylation; Mutation; Neoplasms; Oligonucleotide Array Sequence Analysis; Sequence Analysis, DNA; Telomerase | 2002 |
Detection of aberrant methylation of the p15INK4B gene promoter.
Topics: Blotting, Southern; Cell Cycle Proteins; CpG Islands; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; DNA Primers; Exons; Genes, Tumor Suppressor; Humans; Methylation; Molecular Structure; Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2002 |
High-resolution liquid chromatographic analysis of methylated purine and pyrimidine bases in transfer RNA.
Topics: Adenine; Animals; Cattle; Chemical Phenomena; Chemistry; Chromatography, Liquid; Cytosine; Guanine; Hydrogen-Ion Concentration; Hypoxanthines; Liver; Methylation; Neoplasms; Rats; RNA, Transfer | 1976 |
Replicational fidelity: mechanisms of mutation avoidance and mutation fixation.
Topics: Animals; Cells, Cultured; DNA Repair; DNA Replication; Escherichia coli; Exonucleases; Gene Conversion; Methylation; Mutation; Neoplasms; Pyrimidine Dimers; Recombination, Genetic; Templates, Genetic | 1979 |
A new theory of carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; DNA Repair; Genes; Humans; Methylation; Methyltransferases; Mutagens; Mutation; Neoplasms; Phenotype; Probability | 1979 |
Summation: molecular mechanisms of gene regulation--session 3.
Topics: Animals; Cell Differentiation; Fetus; Glycolysis; Hormones, Ectopic; Humans; Isoenzymes; Methylation; Neoplasms; Oxygen Consumption; Protein Biosynthesis; Pyruvate Kinase; Transcription, Genetic | 1976 |
Serum levels of N2, N2-dimethylguanosine and pseudouridine as determined by radioimmunoassay for patients with malignancy.
Topics: Antibody Specificity; Breast Neoplasms; Guanosine; Humans; Leukemia; Methylation; Neoplasms; Pseudouridine; Radioimmunoassay; Uridine | 1975 |
DNA methylation of coding and non-coding regions of the human H-RAS gene in normal and tumor tissues.
Topics: Alleles; Blotting, Southern; DNA, Neoplasm; Gene Expression Regulation; Genes, ras; Humans; Methylation; Neoplasms; Promoter Regions, Genetic; Proto-Oncogene Proteins p21(ras); Restriction Mapping; RNA, Messenger | 1992 |
The O-methylation of 4-hydroxyestradiol is inhibited by 2-hydroxyestradiol: implications for estrogen-induced carcinogenesis.
Topics: Animals; Catechol O-Methyltransferase; Estradiol; Estrogens; Estrogens, Catechol; Hydrogen-Ion Concentration; Kinetics; Male; Methylation; Neoplasms; Rats; Rats, Inbred Strains | 1990 |
Expression of chorionic gonadotropin alpha- and beta-genes in normal and neoplastic human tissues: relationship to deoxyribonucleic acid structure.
Topics: Cell Line; Chorionic Gonadotropin; Chorionic Gonadotropin, beta Subunit, Human; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Restriction Enzymes; Female; Glycoprotein Hormones, alpha Subunit; Humans; Lung Neoplasms; Lymphocytes; Methylation; Neoplasms; Nucleic Acid Hybridization; Peptide Fragments; Placenta; Polymorphism, Genetic; Pregnancy; Trophoblastic Neoplasms | 1985 |
Induction of adipocyte formation in 10T1/2 cells by 1-methylguanine and 7-methylguanine.
Topics: Adipose Tissue; Animals; Azacitidine; Cell Differentiation; DNA; Guanine; Methylation; Mice; Neoplasms | 1985 |
On the possible contribution of DNA hypomethylation to the induction of high frequency and heritable drug-induced alterations in the malignant phenotype.
Topics: Alkylating Agents; Animals; Azacitidine; Cell Line; DNA, Neoplasm; Gene Amplification; Humans; Methylation; Mice; Mutagens; Mutation; Neoplasms; Neoplasms, Experimental; Phenotype; Thymidine Kinase | 1986 |
Major histocompatibility complex DQ beta gene: polymorphism, methylation state and accumulation of messenger RNA in tumor cells.
Topics: Base Sequence; Deoxyribonuclease HpaII; DNA; DNA Restriction Enzymes; HLA-D Antigens; HLA-DQ Antigens; Humans; Major Histocompatibility Complex; Methylation; Neoplasms; Polymorphism, Genetic; RNA, Messenger | 1986 |
[Modification of the relative plasma concentrations of methyl and methylene groups in cancer: a study using proton NMR spectroscopy].
Topics: Humans; Lipoproteins; Magnetic Resonance Spectroscopy; Methylation; Neoplasms | 1989 |
Proton nuclear magnetic resonance methyl and methylene linewidths from plasma decrease during postprandial lipemia.
Topics: Chylomicrons; Dietary Fats; Female; Food; Humans; Kinetics; Lipids; Lipoproteins; Lipoproteins, VLDL; Magnetic Resonance Spectroscopy; Male; Methylation; Neoplasms; Triglycerides | 1989 |
[NMR research on blood plasma for tumor detection--a method for mass screening?].
Topics: Biomarkers, Tumor; Diagnosis, Differential; Evaluation Studies as Topic; Humans; Lipoproteins; Magnetic Resonance Spectroscopy; Mass Screening; Methylation; Neoplasms | 1989 |
Methylation state of cellular genes and oncogenes as a marker of malignancy in human carcinomas.
Topics: DNA; Gene Amplification; HLA-DR Antigens; Humans; Methylation; Neoplasms; Pancreatic Neoplasms; Proto-Oncogenes; Tumor Cells, Cultured | 1989 |
The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia.
Topics: Calcitonin; Cell Line; Cell Transformation, Viral; Chromosomes, Human, Pair 11; Colonic Neoplasms; Deltaretrovirus; DNA; Fibroblasts; Gene Expression Regulation; Humans; Lung Neoplasms; Lymphocytes; Methylation; Neoplasms; Suppression, Genetic; Teratoma; Tumor Cells, Cultured | 1988 |
Clonal analysis using recombinant DNA probes from the X-chromosome.
Topics: Alleles; Base Sequence; DNA, Neoplasm; DNA, Recombinant; Female; Humans; Hypoxanthine Phosphoribosyltransferase; Methylation; Neoplasms; Phosphoglycerate Kinase; Polymorphism, Restriction Fragment Length; X Chromosome | 1987 |
Cancer genetics. Genomic imprinting and embryonal tumours.
Topics: Alleles; Chromosome Deletion; Methylation; Models, Genetic; Mutation; Neoplasms | 1989 |
Human DNA methylation: methylated DNA-binding protein, differentiation and cancer.
Topics: Aging; Cell Differentiation; DNA; DNA Restriction Enzymes; DNA-Binding Proteins; Female; Fetus; Humans; Methylation; Neoplasms; Pregnancy | 1985 |
Patterns of DNA methylation and gene expression in human tumor cell lines.
Topics: Cell Line; Collagen; Cytosine; DNA, Neoplasm; Gene Expression Regulation; Humans; Methylation; Neoplasms; Polymorphism, Genetic; Proto-Oncogenes; Thymidine Kinase | 1986 |
Methylation of ribosomal RNA as a possible factor in cell differentiation.
Topics: Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Methylation; Neoplasms; Protein Biosynthesis; RNA, Ribosomal | 1987 |
Genetic and epigenetic aspects of tumor progression and tumor heterogeneity.
Topics: Animals; Cell Line; DNA; Humans; Methylation; Neoplasm Metastasis; Neoplasms; Oncogenes | 1985 |
A simple technique for cell surface radioactive labeling of human and animal neoplastic cells: reductive methylation with formaldehyde and tritiated borohydride.
Topics: Animals; Borohydrides; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Electrophoresis; Formaldehyde; Humans; Isotope Labeling; Methylation; Neoplasm Proteins; Neoplasms; Rats; Tritium | 1985 |
The molecular biology of human cancer.
Topics: Chromosome Deletion; DNA; DNA, Neoplasm; Gene Amplification; Humans; Methylation; Mutation; Neoplasms | 1985 |
Methionine metabolism and cancer.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Diet; Gene Expression Regulation; Mammals; Methionine; Methylation; Methyltransferases; Models, Biological; Neoplasms; S-Adenosylmethionine | 1985 |
Polyamines.
Topics: Animals; Cell Differentiation; DNA-Directed RNA Polymerases; Humans; Mammals; Methylation; Neoplasms; Polyamines; Putrescine; RNA; RNA, Messenger; RNA, Transfer; Spermidine; Spermine | 1973 |
[N-demethylation of the carcinogen dimethylnitrosamine by human embryonal tissue (author's transl)].
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Dimethylamines; Embryo, Mammalian; Female; Formaldehyde; Gestational Age; Guinea Pigs; Humans; In Vitro Techniques; Liver; Maternal-Fetal Exchange; Methylation; Microsomes, Liver; Neoplasms; Nitrosamines; Pregnancy; Rats; Species Specificity; Subcellular Fractions | 1974 |
Methylation of RNA by mouse organs and tumors: ionic stimulation in vitro.
Topics: Adenocarcinoma; Animals; Animals, Newborn; Brain; Dialysis; Electrophoresis; Escherichia coli; Kidney; Leukemia Virus, Murine; Leukemia, Lymphoid; Leukemia, Radiation-Induced; Lung; Lung Neoplasms; Methylation; Mice; Neoplasm Transplantation; Neoplasms; Quaternary Ammonium Compounds; RNA, Bacterial; RNA, Transfer; Spleen; Splenic Neoplasms; Temperature; Transferases | 1968 |
Use of mass spectrometry for the carbohydrate composition and sequence analysis of glycosphingolipids.
Topics: Carbohydrates; Ceramides; Fatty Acids; Gangliosides; Glycolipids; Hexosamines; Hexoses; Mass Spectrometry; Methylation; Molecular Weight; Neoplasms; Sialic Acids; Sphingolipids | 1974 |
Is aberrant nucleic acid methylation related to malignant transformation?
Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; Forecasting; Methylation; Methyltransferases; Mice; Models, Biological; Neoplasms; RNA, Neoplasm; RNA, Transfer | 1974 |
Comparison of soluble RNA methylase capacity in paired neoplastic and nonneoplastic cell lines in vitro.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell-Free System; Escherichia coli; Methionine; Methylation; Mice; Neoplasms; RNA, Neoplasm; RNA, Transfer; Transferases | 1969 |
Transfer RNA methylases and cancer.
Topics: Animals; Carbon Isotopes; Carcinogens; Cell Differentiation; Chromatography, Ion Exchange; Escherichia coli; Ethionine; Guanine; Humans; Kidney Neoplasms; Liver Regeneration; Methionine; Methylation; Morphogenesis; Neoplasms; Nitrosamines; Phenylalanine; Protein Biosynthesis; Rats; Ribosomes; RNA, Bacterial; RNA, Messenger; RNA, Transfer; Transferases | 1970 |
Altered transfer RNA methylase patterns in Marek's disease tumors.
Topics: Animals; Carbon Isotopes; Cell Transformation, Neoplastic; Cell-Free System; Chickens; Escherichia coli; Kidney; Kidney Neoplasms; Liver; Liver Neoplasms; Lung; Methylation; Methyltransferases; Myocardium; Neoplasms; Neoplasms, Experimental; Nucleosides; Oncogenic Viruses; Poultry Diseases; RNA, Neoplasm; RNA, Transfer; Spleen; Transferases; Viruses, Unclassified | 1971 |
Initiation of malignant transformation and the significance of changes in transfer RNA methylase enzymes.
Topics: Animals; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Culture Techniques; Female; Kidney; Kidney Neoplasms; Male; Methylation; Methyltransferases; Mice; Neoplasms; Ovarian Neoplasms; Ovary; Prostate; Prostatic Neoplasms; RNA, Transfer; Transferases | 1971 |
Transfer RNA and transfer RNA modification in differentiation and neoplasia. Introduction.
Topics: Methylation; Neoplasms; RNA, Neoplasm; RNA, Transfer; Transferases | 1971 |