Page last updated: 2024-08-18

isomethyleugenol and Neoplasms

isomethyleugenol has been researched along with Neoplasms in 678 studies

Research

Studies (678)

TimeframeStudies, this research(%)All Research%
pre-199080 (11.80)18.7374
1990's58 (8.55)18.2507
2000's95 (14.01)29.6817
2010's265 (39.09)24.3611
2020's180 (26.55)2.80

Authors

AuthorsStudies
Chen, Q; Yang, B1
Cheng, M; Ding, C; Flavell, RA; Li, HB; Peng, H; Song, H; Song, J; Sun, R; Tian, S; Tian, Z; Wang, T; Wei, H; Zheng, M; Zhu, S1
Chen, J; Cook, N; Wu, D; Zhou, J1
Richard, S; Xu, J1
Chen, ZS; Tan, Y; Wang, JQ; Yang, B; Yuan, R; Zou, C1
Kumar, VC; Pai, R1
Ahmad, T; Bacolla, A; Brickner, JR; Casanova, AG; Ganguly, A; He, C; Lukinović, V; Mosammaparast, N; Oyeniran, C; Reynoird, N; Rodell, R; Soll, JM; Sun, H; Tainer, JA; Townley, BA; Tsao, N; Vindigni, A; Wood, M; Zhang, L1
Barros-Silva, D; Jenster, G; Jerónimo, C; Klavert, J; Lafontaine, DLJ; Martens-Uzunova, ES1
Hamada, K; Kono, H; Kumar, A; Machiyama, A; Nishizawa, T; Nureki, O; Ogata, K; Oguni, A; Okada, C; Sakuraba, S; Sato, K; Sengoku, T1
Ghergurovich, JM; Rabinowitz, JD; Ryseck, RP; Wang, JZ; Wang, L; Xu, X; Yang, L1
Bradford, STJ; Dressler, GR; Grimley, E; Laszczyk, AM; Lee, PH; Patel, SR1
Adamo, ME; Cressey, LE; Greiner, EC; Kettenbach, AN; Lyons, SP1
Zhang, W1
Chan, CSY; Cheng, YY; Lau, KS; Leung, WK; Ma, ZY; Ng, L1
Cheng, L; Gong, Y; Liu, L; Lu, S; Ma, F; Peng, Q; Wang, Y; Wei, C1
Gao, C; Li, H; Liu, C; Ma, X; Sun, C; Yu, H; Zhuang, J1
Guo, L; Huang, L; Shi, Y; Yang, H; Zhang, J; Zhou, C1
Alkan, HF; Altea-Manzano, P; Fendt, SM1
Chen, ES; Lam, UTF1
An, Y; Duan, H1
Chen, P; Chen, Y; Han, X; Hu, J1
Aránega, A; Dueñas, Á; Franco, D; García-López, V; Garcia-Martínez, V; García-Padilla, C; López-Sánchez, C1
Hu, D; Li, H; Liu, J; Liu, L; Shao, W; Wang, Y; Yang, S; Zhang, J; Zhong, J1
Gong, Z; Liu, Y; Shi, L; Wang, Y; Xiong, W; Yan, Q; Zeng, Z; Zhang, M; Zhang, S; Zhi, K; Zhi, Y; Zi, M1
Chen, Y; Guan, Q; Guo, H; He, J; Lin, H; Miao, L; Zhuo, Z1
An, S; Kang, JS; Lee, J; Lee, SJ1
Abbasi, Y; Anbiyaee, O; Farzaneh, M; Ghaedrahmati, F; Gholami, E; Kuchaki, Z; Meybodi, SM; Rashid Sheykhahmad, F1
Chen, CJ; Chiou, HY; Hsu, KH; Lee, CH; Liao, PJ1
Atadja, P; Blanz, J; Chen, Z; Dillon, MP; Dubost, V; Fang, D; Feng, L; Fu, X; Gao, Z; Gu, J; Huang, Y; Jeay, S; Kiffe, M; Li, E; Li, L; Lingel, A; Luo, F; Luo, X; Mi, Y; Mistry, P; Moggs, J; Oyang, C; Pearson, D; Piaia, A; Pissot-Soldermann, C; Qi, W; Scheufler, C; Sendzik, M; Sun, Y; Terranova, R; Wang, L; Weiss, A; Yu, Z; Zeng, J; Zhang, H; Zhang, J; Zhang, L; Zhang, Q; Zhao, K; Zhao, M1
Guzman, MIT; Liow, P; Qi, J; Wang, MY1
Deng, L; Fan, Y; Gao, Z; Guo, X; Li, G; Wang, S; Xu, J; Xue, H; Zhang, P; Zhang, Z; Zhao, R1
Akhmetshina, A; Burgering, B; Eisenberg, T; Fasching, S; Hörl, G; Jany-Luig, E; Kerbl-Knapp, J; Korbelius, M; Kratky, D; Kuentzel, KB; Macher, T; Mack, M; Madl, T; Meinitzer, A; Paar, M; Pertschy, B; Pirchheim, A; Rinner, B; Rodriguez Colman, MJ; Stelzl, U; Steyrer, E; Vujić, N; Zhang, F1
Dai, W; Gong, J; Gong, Y; He, F; Li, S; Liu, Q; Tang, F; Wang, Z; Xie, C; Yang, Z; Zhang, J1
Chen, J; Chen, X; Lu, Z; Mo, S; Yu, S; Zong, L1
Guil, S; Ramesh-Kumar, D1
Clement, JH; Crodel, CC; Eifert, T; Ernst, P; Heidel, FH; Hochhaus, A; Hsu, CJ; Huber, N; Hübner, CA; Jayavelu, AK; Perner, F; Schnöder, TM; Tubío-Santamaría, N; Ungelenk, M1
Barghout, SH; Barsyte-Lovejoy, D; Machado, RAC1
Duan, M; Jiang, X; Liu, H; Qian, Y; Wang, G; Wang, Y; Yang, Z; Zhang, F; Zhang, Z1
Han, Y; Ju, HQ; Li, B; Li, H; Li, JJ; Liao, K; Lin, JF; Lu, YX; Luo, XJ; Meng, Q; Tan, YT; Wang, ZX; Wei, C; Xu, RH; Yu, K; Zeng, ZL1
Diao, W; Li, Y; Wang, J; Xu, S; Zheng, J1
Chen, YX; Ju, HQ; Li, T; Liao, K; Lin, J; Mo, HY; Piao, HL; Tan, YT; Wang, W; Xu, RH; Yang, W; Zheng, XJ1
Cavaretta, JP; Huang, L; Huang, T; Lee, MM; Moon, D; Rozen, EJ; Sallis, B; Shohet, JM; Sun, X; Verdejo-Torres, O; Wang, G; Wigglesworth, K; Wu, Q; Zhang, L; Zhang, XO1
Lin, H; Long, F; Wang, P; Wang, T; Wang, Y1
Joosse, SA; Pantel, K1
Acunzo, M; Del Valle-Morales, D; Le, P; Nana-Sinkam, P; Nigita, G; Romano, G; Saviana, M1
Rao, GW; Zhang, W; Zheng, Q1
Klein, EA1
Aggad, WS; Almohaimeed, HM; Alshanwani, AR; Assiri, R; Hengwei, Y; Raza, SHA; Wenzhen, Z; Xinran, Y; Zan, L1
Huang, H; Huang, T; Jiang, J; Li, Y; Wu, S; Zhou, Y1
Abou-Aisha, K; Elsabbagh, RA; Gad, MZ; Rady, M; Watzl, C1
Fan, Y; Gao, Z; Li, X; Sun, H; Yuan, K; Zhu, Z1
Bai, Y; Cui, G; Han, T; Li, Q; Li, X; Li, Y; Lu, D; Qu, D; Sun, H; Sun, X; Wang, S; Yang, Y; Zhang, Q; Zhao, L; Zhao, N1
Cao, Y; Huang, H; Jiang, X; Kuang, Y; Li, X; Ren, C; Shen, W; Wang, L; Yin, W; Zhou, Q; Zhou, Y; Zhu, H1
Aldesoky, AI; Alhanafy, AM; Duose, DY; Gouda, MA; Huang, HJ; Janku, F; Kopetz, S; Lapin, M; Luthra, R; Meric-Bernstam, F; Shehata, MA; Wang, J; Wistuba, II; Xi, Y; Zalles, S; Zheng, X1
Li, F; Xu, YL; Yang, FF1
Chhabra, R; Sarraf, G1
Ge, L; Li, J; Wang, H; Wang, Z; Zhang, H; Zhou, J1
Guo, T; Li, Y; Liu, R; Liu, Y; Yi, J; Zhou, Y1
Hsu, SH; Hung, WC1
Azmani, R; Baud, J; Bochaton, D; Bourdeaut, F; Cardoen, L; Chrétien, F; Croce, S; Duchesne, M; Guillemot, D; Hasty, L; Hostein, I; Kesrouani, C; Le Loarer, F; Le Quang, M; Lechapt, E; Métais, A; Pierron, G; Puget, S; Tauziède-Espariat, A; Varlet, P1
Hong, J; Lee, JH; Xu, K1
Chu, BC; Chung, G; Clement, J; Hubbell, E; Kurtzman, KN; Roberts, LR; Shao, S; Swanton, C; Tang, WHW; Tummala, M; Yimer, H1
Fogle, HM; Krupenko, NI; Krupenko, SA; McCormac, JP; Molina, S; Rushing, BR; Sharma, J; Sumner, S; You, M1
Bi, Z; Cao, J; Feng, Q; Li, L; Yu, L; Zhang, Q; Zhang, Y1
Abedeera, SM; Abeysirigunawardena, SC; Rauff, R; Schmocker, S; Xie, J1
Falone, S; Ponzetti, M; Rucci, N1
Guccione, E; Kaldis, P; Zhao, LN1
Jeoung, D; Jo, H; Shim, K1
Freedy, AM; Kissler, SM; Kwok, HS; Liau, BB; Morriss, JW; Siegenfeld, AP; Waterbury, AL1
Bettegowda, C; Cohen, JD; Curtis, S; Dobbyn, L; Douville, C; Dudley, JC; Ho-Pham, LT; Kinzler, KW; Mattox, A; Nehme, N; Nguyen, TV; Papadopoulos, N; Popoli, M; Ptak, J; Silliman, N; Summers, M; Tran, BNH; Tran, TS; Vogelstein, B; Wang, Y; Zhang, M1
Du, D; He, F; He, J; Ju, C; Li, H; Wang, C; Zhou, M1
Benetti, S; Biancalana, L; Dalla Pozza, M; Gasser, G; Marchetti, F; Zacchini, S1
Fan, C; Guo, C; Hou, X; Jiang, W; Li, G; Li, L; Li, Z; Liao, Q; Ouyang, J; Tang, Q; Wang, F; Wang, H; Wang, Y; Wu, P; Xiang, B; Xiong, W; Zeng, Z; Zhou, M1
He, C; Pomaville, MM1
Liu, Y; Yang, Q1
Bashtrykov, P; Bröhm, A; Bui, T; Jeltsch, A; Khella, MS; Pleiss, J; Schnee, P; Weirich, S1
Chen, G; Chen, L; Chen, X; He, Y; Liu, S; Ni, Z; Qi, S; Xie, T; Zhang, H; Zhao, S; Zhou, Y; Zhu, J1
Liang, Y; Peng, N; Wang, H; Wu, B; Wu, X; Yu, D; Zhong, X1
Jiao, Y; Tao, D; Wang, J; Wang, L; Xu, X; Xu, Y; Yu, B; Zhuang, H1
Huang, X; Lin, D; Zeng, L; Zhang, J; Zheng, J1
Meng, XY1
Buchanan, DD; Dugué, PA; English, DR; Giles, GG; Hodge, AM; Hopper, JL; Joo, JE; Jung, CH; Makalic, E; Milne, RL; Schmidt, D; Severi, G; Southey, MC; Wong, EM; Yu, C1
Bai, C; Chen, S; Gao, S; Guan, H; Han, Y; Huang, R; Huang, X; Jia, J; Li, H; Li, Y; Long, D; Luo, J; Sun, X; Xie, D; Ye, Y; Zhou, PK1
Aldana, J; Freitas, MA; Gardner, ML1
Hong, LL; Li, P; Ling, ZQ; Liu, Z; Qi, YN1
Abbott, KL; Bosenberg, M; Burns, MJ; Chen, D; Esparza Moltó, PB; Farsakoglu, Y; Hargreaves, DC; Hoffmann, FA; Johnson, MA; Kaech, SM; Kunchok, T; Mangalhara, KC; Mendiratta, G; Parisi, B; Rincon, M; Rojas, GR; Sainz, AG; Shadel, GS; Tadepalle, N; Vander Heiden, MG; Varanasi, SK1
Afenjar, A; Banka, S; Barish, S; Bellen, HJ; Blyth, M; Choufani, S; Costain, G; Cytrynbaum, C; Deshwar, AR; Haldeman-Englert, C; Hayes, I; Haynes, D; Huang, Y; Jobling, R; Kanca, O; Keren, B; Le Quesne Stabej, P; Mao, X; Mignot, C; Nil, Z; Prescott, T; Robin-Renaldo, F; Shinawi, M; Sisco, K; Tveten, K; Vøllo, A; Wangler, MF; Wegner, DJ; Weksberg, R; Wheeler, PG; Wilson, C; Yamamoto, S; Yap, P; Zhang, X; Zon, J1
Huo, FC; Pei, DS; Shan, HJ; Zhang, J; Zhu, ZM1
Chai, X; Fang, Z; He, L; Huang, T; Jiang, B; Liu, C; Liu, M; Sun, P; Zeng, D; Zhan, J; Zhang, X; Zhou, X; Zhu, Q1
Perez, MF; Sarkies, P1
Karimian, A; Kurdistani, SK; Vogelauer, M1
Chen, C; Duan, X; Guo, X; Li, L; Sun, S; Wang, L; Wang, W; Wei, Y; Xue, W; Yang, Y; Yao, W; Zhao, J1
Han, M; Hu, J; Liu, J; Sun, H; Sun, Z; Yuan, W; Zhou, Q1
Fan, XN; Huang, Y; Meng, J; Zhang, SW; Zhang, SY; Zhang, T1
Jaffrey, SR; Ries, RJ; Zaccara, S1
Bai, J; Chen, X; Li, X; Li, Y; Qu, Y; Tian, Y; Wang, Q; Xiao, J; Xu, J; Zhang, Y1
Cornett, EM; Defossez, PA; Ferry, L; Rothbart, SB1
Ban, HS; Cho, HS; Han, TS; Hur, K1
Hirata, Y1
Birsoy, K; Weber, R1
Chen, C; Ji, X; Kan, Q; Liu, J; Ma, S; Sun, Z; Wang, G; Yuan, W; Zhou, Q1
Asai, A; Ishii, H; Konno, M; Koseki, J; Taniguchi, M; Vecchione, A1
He, L; Li, H; Peng, Y; Shu, G; Wu, A; Yin, G1
Casanova, AG; Chuffart, F; Lukinović, V; Reynoird, N; Roth, GS1
Gong, C; Hu, Y; Huang, Y; Liu, J; Wang, S; Xiao, Y; Yang, S1
Bai, Y; Fu, X; Jiang, H; Liu, R; Liu, X; Ma, S1
Li, J; Wang, F; Xie, L; Xie, Y1
Margueron, R; Richart, L1
Fujimori, DG; Longbotham, JE; Petronikolou, N1
Muthusamy, S1
Cai, Y; Jin, J; Wei, T; Zhu, H1
Jagtap, SV; Rasal, NK; Sonawane, RB1
Chen, J; Huang, K; Li, J; Li, R; Sun, R; Wang, Y; Xie, K; Yang, Q; Zhang, T; Zhang, Y; Zhao, Q; Zou, L1
Liu, JY; Wellen, KE1
Arnott, D; Cheung, TK; Classon, M; Guler, GD; Lill, J; Masselot, A; Pham, V; Pitti, R; Stephan, JP; Tindell, CA; Wilson, C1
Chen, F; Hao, W; Jiang, M; Lin, J; Liu, B; Sun, D; Tang, C; Xing, H; Yang, J; Yu, M; Zhang, X; Zhao, Y; Zhu, Y1
Bailleux, C; Barranger, E; Delaloge, S; Lacroix, L1
Hussain, S1
Al-Hamashi, AA; Diaz, K; Huang, R1
Choe, J; Han, SH1
Burbage, M; Gros, M1
Asano, T1
Bao, X; Bindra, RS; Dow, J; Economos, NG; Glazer, PM; King, MC; Li, J; Liu, Y; Mirfakhraie, L; Noronha, K; Oeck, S; Shuch, BM; Sulkowski, PL1
Chen, H; Duan, M; Lan, L; Levine, AS; Ouyang, J; Tan, J; Truesdell, SS; Vasudevan, S; Wang, Y; Wei, L; Yadav, T; Yang, H; Zhu, X; Zou, L1
Cheng, L; Li, L; Liang, Y; Liu, M; Wang, R; Xia, J; Yue, L; Zhang, L; Zhang, N1
Deng, D; Liu, W; Tian, W; Xiang, M; You, A1
Bao, Y; Du, R; Gao, W; Li, J; Luo, N; Shen, W; Wang, J; Yang, W; Zhang, X1
He, Q; Qian, M; Yan, F; Yang, B; Yuan, T; Zhu, H1
Klein, EA; Liu, MC; Oxnard, GR; Seiden, M; Swanton, C1
Hao, L; Ji, LN; Mao, ZW; Pan, ZY; Rao, LS; Tan, CP; Zhang, H; Zheng, Y1
Du, W; Duan, R; Guo, W1
Chen, XY; Yi, YC; Zhang, J; Zhu, JS1
Kanbur, E; Stanley, BA; Tümer, E; Yerlikaya, A1
Gubser, PM; Kallies, A1
Huang, W; Li, Y; Weng, H; Zeng, C1
Du, R; Luo, N; Shen, W; Xiang, R; Zhang, X1
Bian, Y; Chinnaiyan, AM; Cieslik, M; Crespo, J; Czerwonka, A; Grove, S; Kremer, DM; Kryczek, I; Li, J; Li, S; Li, W; Liao, P; Liu, JR; Lyssiotis, CA; McLean, K; Nwosu, ZC; Okła, K; Pawłowska, A; Sajjakulnukit, P; Szeliga, W; Vatan, L; Wallner, G; Wei, S; Wertel, I; Xia, H; Yu, J; Zgodziński, W; Zhang, L; Zou, W1
Assaraf, YG; Chen, ZS; Huang, C; Jiang, J; Li, B; Xiao, H1
Fan, W; Kong, Y; Li, N; Tao, T; Xiao, Q; Zhou, Y; Zhu, X1
Huang, G; Yu, Z; Zhang, G1
Chun, KS; Jang, JH; Kim, DH1
Amere Subbarao, S; Kotwal, A1
Huo, FC; Pei, DS; Zhu, ZM1
Klonou, A; Markouli, M; Papavassiliou, AG; Piperi, C; Strepkos, D1
Li, MO; Shyu, A; Xu, K1
Coller, HA; Corvalan, AZ1
Han, X; Wang, M; Yang, Y; Yang, YG; Zhao, YL1
Affar, EB; Barbour, H; Daou, S; Hendzel, M1
Chen, J; He, Z; Ren, D; Tian, Y; Wang, L; Yan, X; Yuan, X; Zhang, Q; Zhang, T; Zhang, W1
Faccin, L; Lapolla, A; Ragazzi, E; Sartore, G1
Ji, LN; Ling, Y; Mao, ZW; Tan, CP; Wang, H; Yang, GG; Zhang, DY; Zhang, H; Zheng, Y1
Kanakamani, S; Suresh, PS; Venkatesh, T1
Annan, RS; Creasy, CL; Liu, Y; McHugh, CF; Mohammad, HP; Montes de Oca, R; Noto, PB; Piccoli, SP; Sikorski, TW; Szapacs, ME; Wagner, CD; Zappacosta, F1
Barshop, W; Bradley, LM; Finlay, D; Garcia, G; Gimple, RC; Hope, JL; Qiu, Z; Rantala, J; Rich, JN; Sangfelt, O; Shen, JZ; Spruck, C; Sun, D; Wohlschlegel, J; Wu, Q1
Cao, Y; Cheng, Z; Deng, P; Gozani, O; Jia, Y; Li, W; Patel, DJ; Qin, Y; Ren, J; Sengupta, D; Tian, W; Wang, Z; Yuan, G; Zhou, Y1
Blyuss, O; Ceroni, F; Conole, D; Di Blasi, R; Timms, JF; Whitwell, HJ1
Goel, PN; Greene, MI; Grover, P1
Fan, M; Li, X; Liu, Z; Pan, S; Wang, H1
Dere, R; Young, NL1
Sroka, MW; Vakoc, CR1
Bai, J; Cai, Y; Chang, Z; Li, D; Li, Y; Xu, J; Xu, K; Zhang, M; Zou, H1
Chen, Y; Duan, L; Jiang, X; Jin, Z; Liu, B; Nie, Z; Xiong, Q; Yang, C1
Allis, CD; Chen, H; Chen, X; Lu, C; Majewski, J; Rajagopalan, KN; Weinberg, DN1
Ribatti, D1
Liu, F; Su, X1
Paramasivam, A; Priyadharsini, JV1
Jeon, M; Kim, H; Lee, JM; Park, IG1
Song, J; Sun, Z; Yuan, W; Zhang, M; Zhang, W1
Broehm, A; Choudalakis, M; Eisler, SA; Fuchs, M; Jeltsch, A; Knodel, F; Kroll, C; Pinter, S; Rathert, P; Roth, M; Schnee, P; Weirich, S; Zuber, J1
Liu, Q; Liu, T; Lu, X; Zheng, S1
Chen, F; Hu, Z; Jiang, Y; Li, Y; Lin, L; Liu, Z; Shen, H; Shen, S; Wei, Y; Zhang, R; Zhao, Y1
Dong, S; Huang, H; Liu, Y; Weng, H; Wu, Y1
Deshmukh, S; Jabado, N; Krug, B; Ptack, A1
Bae, GU; Cho, Y; Hwang, JW; Kim, SN; Kim, YK1
Di Tullio, F; Guccione, E; Mzoughi, S; Schwarz, M1
Jiang, C; Kan, Z; Li, YF; Liu, LY; Ma, WL; Mohammed, R; Nikolaev, A; Song, WW; Zhang, ZF1
Dabelić, N; Fröbe, A; Mojzeš, A; Novak Kujundžić, R; Prpić, M; Tomljanović, M; Trošelj, KG; Đaković, N1
Brownell, JE; Zhai, X1
Fan, Z; Guo, J; Han, X1
Battistelli, C; Garbo, S; Zwergel, C1
Cao, D; Hu, C; Li, C; Li, S; Lv, M; Pan, W; Yang, A; Yang, Z; Yi, X; Zhang, K; Zhang, L; Zhang, P; Zhu, L; Zhu, Y1
Bell, JL; Hüttelmaier, S; Lan, Q; Liu, PY; Liu, T; Wang, JY; Zhang, L; Zhang, XD1
Baek, HJ; Jeon, M; Kim, H; Park, J; Yang, E1
Cai, Z; Jia, G; Song, P; Tayier, S1
Gao, X; Han, B; Li, F; Li, Z; Wei, S; Zhang, J1
Ali, R; Aspris, D; Bernardes, GJL; Bradley, A; De Braekeleer, E; Fischer, ES; Garyfallos, DA; Gregory, RI; Gu, M; Gutierrez, A; Lim, J; Liu, Q; Mikutis, S; Orellana, EA; Pirouz, M; Sendinc, E; Slack, FJ; Tzelepis, K; Vassiliou, GS; Yankova, E; Zhang, W1
Ju, S; Ma, S; Tao, M; Xu, Y; Zhang, W; Zheng, M1
Kong, M; Lowman, XH; Tran, TQ1
Cebrián, ME; Franco-Marina, F; Gamboa-Loira, B; López-Carrillo, L1
Maddocks, ODK; Newman, AC1
Alag, N; Arnott, D; Chen, KB; Classon, M; Cuellar, T; Giresi, PG; Guler, GD; Haley, B; Hegde, G; Jackson, E; Jhunjhunwala, S; KaiWai Cheung, T; Kim, HJ; Liu, J; Nance, TL; Nichols, K; Pitti, R; Settleman, J; Stephan, JP; Tindell, CA; Webster, J; Wilson, C; Wongchenko, M; Yan, Y1
Alam, M; Bouillez, A; Christensen, CL; Hiraki, M; Kufe, D; Rajabi, H; Samur, M; Tagde, A; Wong, KK1
Li, H; Li, J; Ma, Z; Qiu, M; Sun, C; Wang, S; Xia, W; Xu, L; Xu, W; Xu, Y; Yin, R; Zhang, E1
Moritz, LE; Trievel, RC1
Fujioka, K; Hamamoto, R; Nakakido, M; Piao, L1
Copeland, RA; Harvey, D; Ribich, S1
Allahverdi, A; Chung, HH; Cukuroglu, E; Geifman-Shochat, S; Göke, J; Lin, VCL; Madhusudhan, MS; Nordenskiöld, L; Su, IH; Tan, KP; Venkatesan, N; Wong, JF; Yau, YH1
Ding, LN; Duan, YC; Guan, YY; Ma, CY; Ma, YC; Qin, WP; Yang, J; Zhai, XY; Zheng, YC; Zhu, YL1
Hanaki, Y; Hotta, N; Imoto, M; Irie, K; Kikumori, M; Shikata, Y1
Abdullah, LN; Chow, EK; Ho, JC; Jha, S; Kato, H; Lee, KL; Pang, QY; Poellinger, L; Ueda, J; Yang, H1
Chen, YX; Fang, JY; Fu, LN; Tan, J1
He, Z; Huang, J; Liu, B; Lyu, H1
Bridgeman, SC; Ellison, GC; Mamotte, CDS; Melton, PE; Newsholme, P1
Cai, S; Chen, Y; Kong, Y; Wang, Q; Xiao, D1
Di Leva, FS; Fottner, M; Kapp, TG; Kessler, H; Marelli, UK; Marinelli, L; Notni, J; Novellino, E; Räder, AFB; Reich, D; Reichart, F; Steiger, K; Wester, HJ; Wurzer, A1
Akopian, V; Charlton, J; Clement, K; Downing, TL; Gnirke, A; Gu, H; Kiskinis, E; Klages, S; Meissner, A; Pop, R; Santos, DP; Smith, ZD; Timmermann, B; Tsankov, AM; Ziller, MJ1
Li, W; Liu, Y; Ma, P; Pan, Y; Shu, Y1
Coates, P; Galoczova, M; Vojtesek, B1
Bracken, AP; Cagney, G; Chammas, P; Ciferri, C; Conway, E; Deevy, O; Di Croce, L; Fitzpatrick, DJ; Glancy, E; Healy, E; Hokamp, K; Holoch, D; Huang, C; Ishikura, T; Ito, S; Jerman, E; Koseki, H; Koseki, Y; Margueron, R; McLysaght, A; Mucha, M; Nakayama, M; Oliviero, G; Pratt-Kelly, I; Rice, AM; Streubel, G; Watson, A; Wynne, K1
Garza, N; Jin, VX; Kornblau, S; Li, T; Liu, Q1
Cui, YH; He, YY; Robinson, M; Shah, P1
Zhang, S1
Chen, KN; Li, S; Shen, L1
Dai, Z; Gao, X; Locasale, JW; Mentch, SJ; Nichenametla, SN1
Boriack-Sjodin, PA; Copeland, RA; Ribich, S1
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Kouzarides, T; Robson, SC; Xhemalce, B1
Black, JC; Whetstine, JR1
Cock-Rada, A; Weitzman, JB1
Gozani, O; Hammell, M; Joshua-Tor, L; Kuo, A; McCombie, WR; Mills, AA; Paul, S; Schalch, T; Vogel, H1
Huang, S1
Albanese, C; Balent, B; Greally, J; Neumeister, P; Pestell, RG1
Hirohashi, S; Koizume, S; Sekiya, T; Shiraishi, M; Tachibana, K1
Mills, K2
Lökk, J1
Angrand, PO; Chambon, P; Hager, GL; Lerouge, T; Losson, R; Mark, M; Niederreither, K; Rayasam, GV; Song, L; Wendling, O1
LEE, KY; LIJINSKY, W; MAGEE, PN1
CRADDOCK, VM; MAGEE, PN1
Albanes, D; Glynn, SA1
Evans, WE; Krynetski, E1
Bailey, LB1
Clarke, S; Tamanoi, F1
Albiez, H; Cremer, C; Cremer, M; Cremer, T; Stein, S; Wagler, B; Zinner, R1
Aherne, W; Kristeleit, R; Stimson, L; Workman, P1
Altamura, S; Di Bernardo, J; Fusco, A; Giancotti, V; Manfioletti, G; Rustighi, A; Sgarra, R; Tessari, MA1
Krause, E; Lödige, I; Meissner, T; Vinkemeier, U1
Bliek, J; Gaston, V; Gicquel, C; Le Bouc, Y; Maas, S; Mannens, M1
Davie, JR; Drobic, B; Dunn, KL; Espino, PS1
Borja-Aburto, VH; Calderon-Aranda, ES; Cruz-Gonzalez, MB; Del Razo, LM; Garcia-Montalvo, EA; Garcia-Vargas, GG; Valenzuela, OL1
Kean, T; Roth, S; Thanou, M1
Marx, J1
Chang, KM; Chen, IL; Chen, YL; Liao, CH; Lu, PJ; Tsiao, KC; Tzeng, CC; Wang, TC; Wong, CH1
Foley, J; Richard, V; Rosol, TJ1
Allis, CD; Coonrod, SA; Leonelli, L; Perlin, JR; Wang, Y; Wysocka, J1
Esteller, M; Fraga, MF1
Caldas, C; Santos-Rosa, H1
Bell, WC; Grizzle, WE; Heimburger, DC; Henao, OL; Jones, J; Niveleau, A; Piyathilake, CJ1
Baudler, M; Beck, JF; Benimetskaya, L; Gekeler, V; Gimmnich, P; Gonser, B; Grebe, C; Hanauer, G; Hofmann, HP; Leja, A; Maier, T; Pieles, U; Römmele, M; Sanders, K; Stein, CA; Wagner, T1
Hilgeroth, A; Molnár, J; Richter, M1
Esteller, M; Herranz, M2
Frye, M; Watt, FM1
Lee, KD; Lin, CT; Lin, WH; Tzeng, PY1
Si, LS1
Duenas-Gonzalez, A; Perez-Plasencia, C1
Hirohashi, S; Shibata, T1
Huang, SH; Krishnamohan, M; Lam, PK; Maddelena, R; Moore, MR; Ng, JC; Wu, HJ1
Ben-Shushan, E; Bergman, Y; Cedar, H; Eden, E; Farkash, S; Hecht, M; Keshet, I; Reubinoff, BE; Schlesinger, Y; Simon, I; Straussman, R; Yakhini, Z; Zimmerman, J1
Mumby, M1
Cooper, WN; Hesson, LB; Latif, F1
Beekman, C; Bracken, AP; Dietrich, N; Gargiulo, G; Hansen, KH; Helin, K; Kleine-Kohlbrecher, D; Marine, JC; Minucci, S; Pasini, D; Porse, BT; Theilgaard-Mönch, K1
An, W1
Kundu, TK; Reddy, BA; Ruthrotha Selvi, B; Sukanya, MS; Swaminathan, V1
Eisenman, RN; Secombe, J1
Chan, AT; Cui, Y; Cullen, PJ; Jin, H; Jin, J; Kupzig, S; Li, EM; Shen, ZY; Srivastava, G; Tao, Q; Wang, X; Wong, AH; Ying, J; Zhang, Q1
Pal, S; Sif, S1
Domann, FE; Provenzano, MJ1
Shi, Y1
Hanash, S1
Li, K; Teng, LJ1
Guittat, L; Nittis, T; Stewart, SA1
Morrison, Z; Wiencke, JK; Yeh, RF; Zheng, S1
Blanca, A; Carrasco, JC; Requena, MJ1
Brzozowski, Z; Innocenti, A; Kornicka, A; Pomarnacka, E; Saczewski, F; Scozzafava, A; Supuran, CT; Sławiński, J; Temperini, C1
Aas, PA; Feyzi, E; Krokan, HE; Otterlei, M; Slupphaug, G; Sundheim, O; Vågbø, CB; Westbye, MP1
Agger, K; Christensen, J; Cloos, PA; Helin, K1
Chuang, HC; Gaffney, KJ; Kardosh, A; Petasis, NA; Schönthal, AH1
Hancock, RL2
Cheah, MS; Hoffman, RM; Wallace, CD1
Feinberg, AP; Vogelstein, B2
Erb, N; Heller-Schöch, G; Lorenz, H; Müller, J; Schöch, G; Winkler, K1
Hoffman, RM3
Carlow, DA; Elliott, BE; Frost, P; Kerbel, RS; Liteplo, R1
Bynum, GD; Day, RS; Galloway, SM; Girardi, AJ; Lubiniecki, AS; Meyer, SA; Scudiero, DA; Ziolkowski, CH1
Ehrlich, M; Gama-Sosa, MA; Gehrke, CW; Kuo, KC; Oxenhandler, R; Slagel, VA; Trewyn, RW1
Magee, PN; Nyce, J; Weinhouse, S1
Nicolson, GL1
Frost, P; Kerbel, RS1
Razin, A; Szyf, M1
Montgomery, JA; Prejean, JD1
Lo, AC; Nazar, RN; Sitz, TO; Wildeman, AG1
Coe, AM; Mace, R; Swann, PF1
Borek, E2
Kleihues, P; Uozumi, A; Wiestler, OD1
Cline, MJ; deKernion, JB; Slamon, DJ; Verma, IM1
Cheah, MS; Diala, ES; Hoffman, RM; Rowitch, D1
Reitz, RH; Watanabe, PG1
Day, RS; Yagi, T; Yarosh, DB1
Pegg, AE1
Agrawal, HP; Randerath, E; Randerath, K1
Borek, E; Sharma, OK; Waalkes, TP1
Hanski, C; Stehlik, G1
Beck, BD; Boardman, PD; Carlson-Lynch, H1
Bhagwat, AS; Yebra, MJ1
Deal, CL1
Little, M; Wainwright, B1
Baylin, SB; Burger, PC; Gabrielson, E; Herman, JG; Lee, DJ; Mao, L; Merlo, A; Sidransky, D1
Christman, JK1
Grigg, GW; Holliday, R1
Pfeifer, GP; Tornaletti, S1
Mishina, M; Ogawa, O; Yoshida, O1
Miwa, W; Sekine, T; Sekiya, T; Yashima, K1
Doerfler, W1
Bignami, M; Karran, P1
Jaenisch, R; Laird, PW1
Rogers, AE1
Counts, JL; Goodman, JI3
Feinberg, AP; Rainier, S1
Jones, PA; Magewu, AN1
Bolt, HM; Gansewendt, B1
De-Groot, N; Hochberg, A1
Pourcel, C1
Feinberg, AP2
Dosch, J; Fritz, G; Kaina, B; Thielmann, HW1
Holliday, R3
Jones, PA; Rideout, WM; Spruck, CH1
Briggs, RS; Ganderton, RH1
Schwab, M1
Balmain, A1
Brugger, W; Kanz, L; Lübbert, M; Mertelsmann, R1
DeBaun, MR; Feinberg, AP; Rainier, S1
Christensen, B1
MacLeod, MC1
Heby, O1
Jones, PA3
Kunkel, TA; Umar, A1
Boon, T; Brasseur, F; De Backer, O; De Smet, C; Faraoni, I; Lurquin, C1
Sakai, T1
Beck, BD; Chapnick, SD; Gauthier, TD; Jones, L; Reynolds, KA; Schoof, RA; Slayton, TM; Valberg, PA; Yost, LJ1
Maclennan, R; Nixon, P; Seitz, HK; Watson, RR1
Kaiser, J1
Biggs, ML; Ferreccio, C; Haque, R; Hopenhayn-Rich, C; Moore, L; Smith, A1
Ip, C1
Ganther, HE1
Collins, JM; Katki, AG; Klecker, RW1
Fearon, ER1
Baylin, SB; Belinsky, SA; Herman, JG1
Ahmad, S; Cullen, WR; Kitchin, KT1
Prokhorchuk, AV; Ruzov, AS1
Issa, JP; Kantarjian, HM; Santini, V1
Kitchin, KT1
Allis, CD; Rice, JC1
Pennisi, E1
Chen, CJ; Chiou, HY; Hsueh, YM; Lee, TC; Wang, IH; Wang, TW; Wu, MM1
Mathé, G1
Uchida, T1
Zhu, BT1
Lakings, DB; Mrochek, JE; Waalkes, TP1
Boiteux, S; Glickman, BW; Kinsella, AR; Radman, M; Spadari, S; Villani, G1
Nau, F1
Weinhouse, S1
Guldberg, HC; Marsden, CA1
Levine, L; Stolbach, L; Waalkes, TP1
Sasaki, H1
Baylin, SB1
Jones, PA; Rideout, WM; Shen, JC; Spruck, CH; Tsai, YC1
Biassoni, D; Borrello, MG; Della Porta, G; Pierotti, MA; Pilotti, S; Rizzetti, MG; Tamborini, E1
Baylin, SB; de Bustros, A; Makos, M; Nelkin, BD; Vertino, P; Wu, JJ; Yen, RW1
Hall, JG1
DiMaria, P; Duerre, JA; Kim, S; Paik, WK1
Bartsch, H; Calmels, S; Ohshima, H; Pignatelli, B; Shuker, DE1
Liehr, JG; Roy, D; Weisz, J1
Buckley, JD; Jones, PA1
Kourides, IA; Whitfield, GK1
Kerr, SJ1
Frost, P; Kerbel, RS; Liteplo, R1
Newberne, PM; Rogers, AE1
Barbieri, R; del Senno, L; Gambari, R; Piva, MR1
Chandler, LA; Jones, PA1
Shire, JG1
Carcassonne, Y; Confort-Gouny, S; Favre, R; Fontanarava, E; Grisoli, F; Harlé, JR; Kriat, M; Mongin, M; Sciaky, M; Vion-Dury, J1
Evans, HJ1
Benham, DF; Busby, MJ; Glickson, JD; McLennan, I; Verdery, RB; Wehrle, JP1
Enoki, Y; Niwa, O; Yokoro, K1
Fritzsche, H; Jahn, H; Jorke, D; Sprinz, H1
Barbieri, R; Buzzoni, D; del Senno, L; Gambari, R; Giacomini, P; Mischiati, C; Nastruzzi, C; Natali, PG; Orlando, P; Piva, R1
Baylin, SB; de Bustros, A; Ehrlich, G; Nelkin, BD; Poiesz, B; Silverman, A1
Fearon, ER; Hamilton, SR; Michelson, AM; Orkin, SH; Preisinger, AC; Riggs, AD; Vogelstein, B; Willard, HF1
Reik, W; Surani, MA1
Ehrlich, M; Wang, RY; Zhang, XY1
Guirguis, RA; Liotta, LA; Schiffmann, E1
Frost, P; Kendal, WS1
Spandidos, DA1
Bogenmann, E; Chandler, LA; DeClerck, YA; Jones, PA1
Munholland, JM; Nazar, RN1
Frost, P; Kerbel, RS; Liteplo, RG1
Chorváth, B; Duraj, J; Sedlák, J1
van der Westhuyzen, J1
Ivankovic, S; Schmähl, D; Zeller, WJ1
Kaye, AM; Leboy, PS1
McCarty, KS1
Karlsson, KA; Pascher, I; Pimlott, W; Samuelsson, BE1
Gantt, RR1
Evans, VJ; Gantt, R1
Datta, B; Datta, RK1
Craddock, VM1
Magee, PN1
Zamecnik, PC1
Hacker, B; Maag, TA; Mandel, LR1
Pillinger, DJ; Wilkinson, R1

Reviews

332 review(s) available for isomethyleugenol and Neoplasms

ArticleYear
Cross-Talk between Oxidative Stress and m
    Oxidative medicine and cellular longevity, 2021, Volume: 2021

    Topics: Humans; Methylation; Neoplasms; Oxidative Stress; RNA

2021
Embryonic Ectoderm Development (EED) as a Novel Target for Cancer Treatment.
    Current topics in medicinal chemistry, 2021, Volume: 21, Issue:31

    Topics: Allosteric Site; Animals; Histones; Humans; Methylation; Molecular Targeted Therapy; Neoplasms; Polycomb Repressive Complex 2

2021
Cellular pathways influenced by protein arginine methylation: Implications for cancer.
    Molecular cell, 2021, 11-04, Volume: 81, Issue:21

    Topics: Alternative Splicing; Animals; Arginine; B7-H1 Antigen; Cell Communication; Cell Line, Tumor; CRISPR-Cas Systems; DNA Damage; DNA Repair; Enzyme Inhibitors; Epigenesis, Genetic; Histones; Humans; Immune System; Immunotherapy; Methylation; Mice; Mice, Knockout; Neoplasms; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; RNA Splicing; RNA, Messenger; Signal Transduction

2021
RNA methylation and cancer treatment.
    Pharmacological research, 2021, Volume: 174

    Topics: Animals; Humans; Methylation; Neoplasms; RNA

2021
Genes of the month: H3.3 histone genes: H3F3A and H3F3B.
    Journal of clinical pathology, 2021, Volume: 74, Issue:12

    Topics: Acetylation; Animals; Chromatin Assembly and Disassembly; DNA Methylation; Genetic Predisposition to Disease; Histones; Humans; Methylation; Mutation; Neoplasms; Neurodevelopmental Disorders; Protein Processing, Post-Translational

2021
The role of OncoSnoRNAs and Ribosomal RNA 2'-O-methylation in Cancer.
    RNA biology, 2021, 10-15, Volume: 18, Issue:sup1

    Topics: Animals; Humans; Methylation; Neoplasms; Ribosomes; RNA Processing, Post-Transcriptional; RNA, Ribosomal; RNA, Small Nucleolar

2021
N6-Methyladenosine RNA Modification in the Tumor Immune Microenvironment: Novel Implications for Immunotherapy.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Adenosine; Animals; Humans; Immunotherapy; Methylation; Neoplasms; RNA; Tumor Microenvironment

2021
Molecular mechanisms in governing genomic stability and tumor suppression by the SETD2 H3K36 methyltransferase.
    The international journal of biochemistry & cell biology, 2022, Volume: 144

    Topics: Animals; Carcinogenesis; Chromatin; Genomic Instability; Histones; Humans; Lysine; Mammals; Methylation; Neoplasms

2022
The role of m6A RNA methylation in cancer metabolism.
    Molecular cancer, 2022, 01-12, Volume: 21, Issue:1

    Topics: Adenosine; Animals; Biomarkers; Disease Management; Disease Susceptibility; Energy Metabolism; Gene Expression Regulation, Neoplastic; Humans; Methylation; Mitochondria; Neoplasms; RNA; RNA Processing, Post-Transcriptional; RNA, Circular; RNA, Messenger; RNA, Untranslated; Signal Transduction; Transcription Factors

2022
Advances in the functional roles of N6-methyladenosine modification in cancer progression: mechanisms and clinical implications.
    Molecular biology reports, 2022, Volume: 49, Issue:6

    Topics: Adenosine; Humans; Methylation; Neoplasms; RNA, Messenger

2022
Molecular Mechanisms of lncRNAs in the Dependent Regulation of Cancer and Their Potential Therapeutic Use.
    International journal of molecular sciences, 2022, Jan-11, Volume: 23, Issue:2

    Topics: Animals; Biomarkers, Tumor; Carcinogenesis; Disease Management; Disease Susceptibility; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genetic Engineering; Genetic Predisposition to Disease; Genetic Therapy; Histones; Humans; Methylation; Molecular Targeted Therapy; Neoplasms; Oncogenes; Protein Processing, Post-Translational; RNA Processing, Post-Transcriptional; RNA, Long Noncoding

2022
Insights into N6-methyladenosine and programmed cell death in cancer.
    Molecular cancer, 2022, 01-28, Volume: 21, Issue:1

    Topics: Adenosine; Apoptosis; Humans; Methylation; Neoplasms

2022
Potential applications of N
    Wiley interdisciplinary reviews. RNA, 2022, Volume: 13, Issue:5

    Topics: Apoptosis; Autophagy; Carcinogenesis; Ferroptosis; Humans; Methylation; Neoplasms

2022
Functions, mechanisms, and therapeutic implications of METTL14 in human cancer.
    Journal of hematology & oncology, 2022, 02-03, Volume: 15, Issue:1

    Topics: Adenine; Animals; Carcinogenesis; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; Neoplasms; Prognosis; RNA

2022
Protein Arginine Methyltransferases in Neuromuscular Function and Diseases.
    Cells, 2022, 01-21, Volume: 11, Issue:3

    Topics: Antineoplastic Agents; Humans; Methylation; Neoplasms; Neuromuscular Diseases; Protein-Arginine N-Methyltransferases; Quality of Life

2022
Emerging roles of JMJD3 in cancer.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2022, Volume: 24, Issue:7

    Topics: Apoptosis; Female; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Neoplasms

2022
Exploring Methods of Targeting Histone Methyltransferases and Their Applications in Cancer Therapeutics.
    ACS chemical biology, 2022, 04-15, Volume: 17, Issue:4

    Topics: Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Methyltransferases; Neoplasms

2022
Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Arginine; Humans; Immunologic Factors; Immunotherapy; Methylation; Neoplasms; Protein-Arginine N-Methyltransferases; Quality of Life

2022
The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer.
    Seminars in cancer biology, 2022, Volume: 86, Issue:Pt 3

    Topics: Adenosine; Humans; Methylation; Neoplasms; RNA-Binding Proteins; RNA, Messenger

2022
Chemical biology and pharmacology of histone lysine methylation inhibitors.
    Biochimica et biophysica acta. Gene regulatory mechanisms, 2022, Volume: 1865, Issue:6

    Topics: Biology; Epigenesis, Genetic; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Neoplasms; Protein Processing, Post-Translational

2022
Crosstalk among m
    Journal of hematology & oncology, 2022, 07-06, Volume: 15, Issue:1

    Topics: Ecosystem; Humans; Hypoxia; Methylation; Neoplasms; RNA; Tumor Microenvironment

2022
Targeting histone demethylases as a potential cancer therapy (Review).
    International journal of oncology, 2022, Volume: 61, Issue:3

    Topics: Histone Demethylases; Histones; Humans; Lysine; Methylation; Neoplasms

2022
Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance.
    Molecular cancer, 2022, 07-18, Volume: 21, Issue:1

    Topics: Adenosine; Drug Resistance, Neoplasm; Humans; Methylation; Neoplasms; RNA, Circular

2022
The Epitranscriptome in miRNAs: Crosstalk, Detection, and Function in Cancer.
    Genes, 2022, 07-21, Volume: 13, Issue:7

    Topics: Humans; Methylation; MicroRNAs; Neoplasms; RNA Processing, Post-Transcriptional

2022
Protein Lysine Methyltransferase SMYD2: A Promising Small Molecule Target for Cancer Therapy.
    Journal of medicinal chemistry, 2022, 08-11, Volume: 65, Issue:15

    Topics: Histone-Lysine N-Methyltransferase; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational

2022
Research progress of m
    Molecular and cellular probes, 2022, Volume: 65

    Topics: Adenosine; Animals; Growth and Development; Humans; Methylation; Neoplasms; RNA; RNA, Messenger

2022
The Role of RNA m
    Current gene therapy, 2023, Volume: 23, Issue:1

    Topics: Adenosine; Glycolysis; Humans; Methylation; Neoplasms; RNA; Tumor Microenvironment

2023
Impact of N6-methyladenosine (m
    Cell communication and signaling : CCS, 2022, 09-09, Volume: 20, Issue:1

    Topics: Adenosine; Humans; Methylation; Methyltransferases; Neoplasms

2022
Role of WTAP in Cancer: From Mechanisms to the Therapeutic Potential.
    Biomolecules, 2022, 09-02, Volume: 12, Issue:9

    Topics: Cell Cycle Proteins; Humans; Methylation; Methyltransferases; Neoplasms; RNA; RNA Splicing Factors; RNA, Messenger

2022
The role of lncRNA just proximal to XIST (JPX) in human disease phenotypes and RNA methylation: The novel biomarker and therapeutic target potential.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 155

    Topics: Biomarkers; Humans; Methylation; Neoplasms; Phenotype; RNA, Long Noncoding

2022
[Research Progress of m6A Methylation Modification in Hematological Tumors--Review].
    Zhongguo shi yan xue ye xue za zhi, 2022, Volume: 30, Issue:5

    Topics: Adenosine; Epigenesis, Genetic; Hematologic Neoplasms; Humans; Methylation; Neoplasms; RNA, Messenger

2022
Emerging role of mRNA methylation in regulating the hallmarks of cancer.
    Biochimie, 2023, Volume: 206

    Topics: DNA; Humans; Methylation; Methyltransferases; Neoplasms; RNA; RNA Processing, Post-Transcriptional; RNA, Messenger

2023
RNA m
    Molecular oncology, 2023, Volume: 17, Issue:2

    Topics: Humans; Methylation; Neoplasms; RNA; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Untranslated

2023
Protein arginine methyltransferase 3: A crucial regulator in metabolic reprogramming and gene expression in cancers.
    Cancer letters, 2023, 02-01, Volume: 554

    Topics: Arginine; Gene Expression; Humans; Methylation; Neoplasms; Protein-Arginine N-Methyltransferases

2023
Biological roles of the RNA m
    Experimental & molecular medicine, 2022, Volume: 54, Issue:11

    Topics: Adenosine; Humans; Methylation; Neoplasms; RNA; RNA, Messenger

2022
RNA methylation and cellular response to oxidative stress-promoting anticancer agents.
    Cell cycle (Georgetown, Tex.), 2023, Volume: 22, Issue:8

    Topics: Animals; Antineoplastic Agents; Epigenesis, Genetic; Epigenome; Homeostasis; Humans; Methylation; Mitochondria; Neoplasms; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Recurrence; RNA; RNA Processing, Post-Transcriptional; Transcriptome

2023
Roles of RNA Methylations in Cancer Progression, Autophagy, and Anticancer Drug Resistance.
    International journal of molecular sciences, 2023, Feb-20, Volume: 24, Issue:4

    Topics: Antineoplastic Agents; Autophagy; Humans; Methylation; Neoplasms; RNA

2023
When N
    Cancer letters, 2023, 05-28, Volume: 562

    Topics: Humans; Methylation; MicroRNAs; Neoplasms; RNA, Messenger; RNA, Transfer

2023
RNA modifications in cancer.
    British journal of cancer, 2023, Volume: 129, Issue:2

    Topics: Humans; Methylation; Neoplasms; RNA; RNA Processing, Post-Transcriptional; RNA, Messenger

2023
Advances in targeting RNA modifications for anticancer therapy.
    Trends in cancer, 2023, Volume: 9, Issue:7

    Topics: Animals; Carcinogenesis; Humans; Mammals; Methylation; Methyltransferases; Neoplasms; RNA; RNA, Messenger

2023
The roles of EZH2 in cancer and its inhibitors.
    Medical oncology (Northwood, London, England), 2023, May-06, Volume: 40, Issue:6

    Topics: Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Methylation; Neoplasms; Polycomb Repressive Complex 2

2023
The roles and mechanism of m
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 163

    Topics: Adenosine; Humans; Methylation; Methyltransferases; Neoplasms; RNA; Tumor Microenvironment

2023
The emerging role of N
    Environmental pollution (Barking, Essex : 1987), 2023, Aug-15, Volume: 331, Issue:Pt 1

    Topics: Carcinogenesis; Humans; Ions; Metals, Heavy; Methylation; Neoplasms; RNA, Messenger

2023
The role of m6A methylation in therapy resistance in cancer.
    Molecular cancer, 2023, 06-01, Volume: 22, Issue:1

    Topics: Epigenesis, Genetic; Humans; Methylation; Neoplasms; RNA; RNA Splicing

2023
Roles and implications of mRNA N
    Cancer communications (London, England), 2023, Volume: 43, Issue:7

    Topics: Epigenesis, Genetic; Humans; Methylation; Neoplasms; RNA; RNA, Messenger

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide

2023
Methyltransferase-like proteins in cancer biology and potential therapeutic targeting.
    Journal of hematology & oncology, 2023, 08-02, Volume: 16, Issue:1

    Topics: Adenosine; Biology; Humans; Methylation; Methyltransferases; MicroRNAs; Neoplasms

2023
Crosstalk between m6A modification and alternative splicing during cancer progression.
    Clinical and translational medicine, 2023, Volume: 13, Issue:10

    Topics: Alternative Splicing; Animals; Mammals; Methylation; Neoplasms; RNA; RNA-Binding Proteins; RNA, Messenger

2023
The role of N6-methyladenosine methylation in PAHs-induced cancers.
    Environmental science and pollution research international, 2023, Volume: 30, Issue:56

    Topics: Biomarkers; Humans; Methylation; Neoplasms; RNA

2023
Effects of RNA methylation on Tumor angiogenesis and cancer progression.
    Molecular cancer, 2023, Dec-06, Volume: 22, Issue:1

    Topics: Humans; Methylation; Neoplasms; Neovascularization, Pathologic; RNA

2023
Reading, writing and erasing mRNA methylation.
    Nature reviews. Molecular cell biology, 2019, Volume: 20, Issue:10

    Topics: Adenosine; Animals; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Neoplasm

2019
Lysine Methylation Regulators Moonlighting outside the Epigenome.
    Molecular cell, 2019, 09-19, Volume: 75, Issue:6

    Topics: Animals; Epigenome; Humans; Lysine; Methylation; Neoplasm Proteins; Neoplasms; Protein Processing, Post-Translational; Signal Transduction

2019
Epigenetic Alterations of Heat Shock Proteins (HSPs) in Cancer.
    International journal of molecular sciences, 2019, Sep-25, Volume: 20, Issue:19

    Topics: Animals; Apoptosis; Biomarkers, Tumor; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; Histones; Humans; Methylation; MicroRNAs; Molecular Targeted Therapy; Neoplasms; Protein Processing, Post-Translational

2019
[Reactive Oxygen Species (ROS) Signaling: Regulatory Mechanisms and Pathophysiological Roles].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2019, Volume: 139, Issue:10

    Topics: Adenosine Triphosphate; Alarmins; Apoptosis; Atherosclerosis; Humans; Inflammation; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 5; Methylation; Neoplasms; Neurodegenerative Diseases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Reactive Oxygen Species; Signal Transduction; Trans Fatty Acids; Ubiquitin-Protein Ligases; Ubiquitination

2019
The interplay between m6A RNA methylation and noncoding RNA in cancer.
    Journal of hematology & oncology, 2019, 11-22, Volume: 12, Issue:1

    Topics: Adenosine; Humans; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Neoplasm; RNA, Untranslated

2019
Functions of N6-methyladenosine and its role in cancer.
    Molecular cancer, 2019, 12-04, Volume: 18, Issue:1

    Topics: Adenosine; Animals; Biomarkers; Disease Susceptibility; Gene Expression Regulation, Neoplastic; Humans; Methylation; Molecular Targeted Therapy; Neoplasms; Protein Binding; RNA, Messenger; Signal Transduction

2019
Lysine Methyltransferases Signaling: Histones are Just the Tip of the Iceberg.
    Current protein & peptide science, 2020, Volume: 21, Issue:7

    Topics: Chromosomal Proteins, Non-Histone; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histones; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Neoplasms; Protein Processing, Post-Translational; Signal Transduction

2020
New sights in cancer: Component and function of N6-methyladenosine modification.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 122

    Topics: Adenosine; Animals; Epigenesis, Genetic; Humans; Methylation; Neoplasms; RNA; RNA, Messenger

2020
Post-translational modifications of protein in response to ionizing radiation.
    Cell biochemistry and function, 2020, Volume: 38, Issue:3

    Topics: Amino Acid Motifs; DNA Damage; Genome, Human; Glycosylation; Humans; Methylation; Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Proteins; Radiation, Ionizing; Signal Transduction; Ubiquitination

2020
Drugging histone methyltransferases in cancer.
    Current opinion in chemical biology, 2020, Volume: 56

    Topics: Antineoplastic Agents; Carcinogenesis; Chromatin; Drug Design; Drug Therapy, Combination; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Expression Regulation; Histone Methyltransferases; Humans; Methylation; Mutation; Neoplasms

2020
m
    Gene, 2020, Apr-30, Volume: 736

    Topics: Disease Progression; Homeostasis; Humans; Methylation; Neoplasms; RNA, Messenger; Transcriptome

2020
Small Molecules Targeting the Specific Domains of Histone-Mark Readers in Cancer Therapy.
    Molecules (Basel, Switzerland), 2020, Jan-29, Volume: 25, Issue:3

    Topics: Acetylation; Animals; Antineoplastic Agents; Drug Delivery Systems; Epigenesis, Genetic; Histone Code; Humans; Methylation; Neoplasms; Protein Binding; Protein Domains

2020
Advances into understanding metabolites as signaling molecules in cancer progression.
    Current opinion in cell biology, 2020, Volume: 63

    Topics: Acetylation; Animals; Disease Progression; Glycosylation; Humans; Metabolome; Methylation; Neoplasm Proteins; Neoplasms; Protein Processing, Post-Translational; Signal Transduction

2020
Non-Histone Arginine Methylation by Protein Arginine Methyltransferases.
    Current protein & peptide science, 2020, Volume: 21, Issue:7

    Topics: Antineoplastic Agents; Arginine; Cardiovascular Diseases; Enzyme Inhibitors; Epigenesis, Genetic; Histones; Humans; Metabolic Diseases; Methylation; Neoplasms; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; RNA Splicing; Signal Transduction; Transcription Factors

2020
Diverse molecular functions of m
    Experimental & molecular medicine, 2020, Volume: 52, Issue:5

    Topics: Adenosine; Alternative Splicing; Animals; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; Nucleic Acid Conformation; Organ Specificity; RNA Processing, Post-Transcriptional; RNA Stability; RNA, Messenger; Structure-Activity Relationship

2020
Drug Resistance in Cancer Therapy and the Role of Epigenetics.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2020, Dec-14, Volume: 87, Issue:5

    Topics: Acetylation; Antigens, Neoplasm; Antineoplastic Agents; DNA Repair; Drug Resistance, Neoplasm; Epigenomics; Gene Expression; Histones; Humans; Membrane Transport Proteins; Methylation; Molecular Targeted Therapy; Neoplasms

2020
Targeting post-translational modification of transcription factors as cancer therapy.
    Drug discovery today, 2020, Volume: 25, Issue:8

    Topics: Acetylation; Animals; Humans; Methylation; Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Transcription Factors

2020
EZH2: a novel target for cancer treatment.
    Journal of hematology & oncology, 2020, 07-28, Volume: 13, Issue:1

    Topics: Adenosine; Antineoplastic Agents; Benzamides; Biphenyl Compounds; Cell Cycle; Cell Transformation, Neoplastic; Clinical Trials as Topic; Combined Modality Therapy; Drug Resistance, Neoplasm; Enhancer of Zeste Homolog 2 Protein; Epigenetic Repression; Histone Code; Histones; Humans; Methylation; Morpholines; Multicenter Studies as Topic; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Polycomb Repressive Complex 2; Pyridones; Structure-Activity Relationship; Transcriptional Activation; Tumor Microenvironment

2020
Novel insights into the interplay between m
    Molecular cancer, 2020, 08-07, Volume: 19, Issue:1

    Topics: Adenosine; Animals; Carcinogenesis; Disease Susceptibility; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Methylation; MicroRNAs; Neoplasms; RNA Interference; RNA, Circular; RNA, Long Noncoding; RNA, Messenger; RNA, Untranslated

2020
The Ubiquitin-Proteasome Pathway and Epigenetic Modifications in Cancer.
    Anti-cancer agents in medicinal chemistry, 2021, Volume: 21, Issue:1

    Topics: Acetylation; Boron Compounds; Bortezomib; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Glycine; Histone Acetyltransferases; Histone Deacetylases; Humans; Hydroxamic Acids; Methylation; Neoplasms; NF-kappa B; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Signal Transduction; Terphenyl Compounds; Ubiquitin; Ubiquitination; Valproic Acid

2021
Roles of METTL3 in cancer: mechanisms and therapeutic targeting.
    Journal of hematology & oncology, 2020, 08-27, Volume: 13, Issue:1

    Topics: Adenosine; Antineoplastic Agents; Binding, Competitive; Carcinogens; Drug Design; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; Models, Molecular; Molecular Targeted Therapy; Neoplasm Proteins; Neoplasms; Oncogenes; Protein Conformation; Protein Domains; Recombinant Fusion Proteins; RNA Processing, Post-Transcriptional; RNA, Neoplasm; Substrate Specificity; Tumor Suppressor Proteins

2020
Surmounting cancer drug resistance: New insights from the perspective of N
    Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 2020, Volume: 53

    Topics: Adenosine; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Disease Models, Animal; DNA Damage; DNA Repair; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Immune Checkpoint Inhibitors; Methylation; Neoplasms; Protein Kinase Inhibitors; RNA Processing, Post-Transcriptional; Treatment Outcome; Tumor Microenvironment

2020
Principles of RNA methylation and their implications for biology and medicine.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 131

    Topics: Adenine; AlkB Homolog 5, RNA Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Humans; Methylation; Neoplasms; RNA; RNA Processing, Post-Transcriptional; Spermatogenesis; T-Lymphocytes; Virus Diseases

2020
Perspectives Regarding the Intersections between STAT3 and Oxidative Metabolism in Cancer.
    Cells, 2020, 09-29, Volume: 9, Issue:10

    Topics: Acetylation; Cell Respiration; Humans; Methylation; Mitochondria; Neoplasms; Oxidation-Reduction; Oxidative Stress; Peroxidases; Phosphorylation; Protein Processing, Post-Translational; STAT3 Transcription Factor

2020
N
    Cell proliferation, 2020, Volume: 53, Issue:11

    Topics: Adenosine; Animals; Disease Progression; Humans; Methylation; Methyltransferases; Neoplasms; RNA, Messenger

2020
Histone Methyltransferase SETDB1: A Common Denominator of Tumorigenesis with Therapeutic Potential.
    Cancer research, 2021, 02-01, Volume: 81, Issue:3

    Topics: Carcinogenesis; Down-Regulation; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplasm Proteins; Neoplasms; Protein Processing, Post-Translational; Repressor Proteins; Transcription, Genetic

2021
Methylation of histone 4's lysine 20: a critical analysis of the state of the field.
    Physiological genomics, 2021, 01-01, Volume: 53, Issue:1

    Topics: Animals; Cell Cycle; Embryonic Development; Histones; Humans; Lysine; Methylation; Neoplasms

2021
RNA methylations in human cancers.
    Seminars in cancer biology, 2021, Volume: 75

    Topics: Animals; Biomarkers, Tumor; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms

2021
Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes.
    Nature communications, 2020, 11-23, Volume: 11, Issue:1

    Topics: Animals; Chromatin; Deubiquitinating Enzymes; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms; Polycomb-Group Proteins; Ubiquitination

2020
Novel Insights Into the Role of N6-Methyladenosine RNA Modification in Bone Pathophysiology.
    Stem cells and development, 2021, 01-01, Volume: 30, Issue:1

    Topics: Adenosine; Bone and Bones; Cartilage; Humans; Methylation; MicroRNAs; Neoplasms; RNA; RNA, Long Noncoding; RNA, Messenger

2021
Regulation of processing bodies: From viruses to cancer epigenetic machinery.
    Cell biology international, 2021, Volume: 45, Issue:4

    Topics: Animals; Cytoplasm; Epigenesis, Genetic; Gene Expression Regulation; Humans; Methylation; MicroRNAs; Neoplasms; Organelles; Protein Processing, Post-Translational; Ribonucleoproteins; RNA, Messenger; Viruses

2021
Non-Histone Protein Methylation: Biological Significance and Bioengineering Potential.
    ACS chemical biology, 2021, 02-19, Volume: 16, Issue:2

    Topics: Alzheimer Disease; Animals; Bioengineering; Cell Cycle; Humans; Methylation; Mitochondria; Neoplasms; Protein Processing, Post-Translational; Proteins

2021
PRMT5 and Tip60 Modify FOXP3 Function in Tumor Immunity.
    Critical reviews in immunology, 2020, Volume: 40, Issue:4

    Topics: Arginine; Epigenesis, Genetic; Forkhead Transcription Factors; Humans; Methylation; Neoplasms; Protein-Arginine N-Methyltransferases

2020
Serine, glycine and one‑carbon metabolism in cancer (Review).
    International journal of oncology, 2021, Volume: 58, Issue:2

    Topics: Animals; Antineoplastic Agents; Carbon; Carcinogenesis; Disease Models, Animal; Glycine; Humans; Metabolic Networks and Pathways; Methylation; Mice; Neoplasms; Oxidation-Reduction; Serine; Tumor Microenvironment; Warburg Effect, Oncologic

2021
Mechanistic insights into KDM4A driven genomic instability.
    Biochemical Society transactions, 2021, 02-26, Volume: 49, Issue:1

    Topics: Animals; Cell Transformation, Neoplastic; Genomic Instability; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Neoplasms; Protein Processing, Post-Translational; Signal Transduction

2021
The role of m6A modification in the biological functions and diseases.
    Signal transduction and targeted therapy, 2021, 02-21, Volume: 6, Issue:1

    Topics: Adenosine; Epigenesis, Genetic; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Methylation; Methyltransferases; Neoplasms; Nerve Tissue Proteins; RNA Processing, Post-Transcriptional; RNA Splicing Factors; RNA-Binding Proteins

2021
Epigenetics and Its Ethical Implications.
    Critical reviews in eukaryotic gene expression, 2021, Volume: 31, Issue:1

    Topics: Diabetes Mellitus, Type 2; Epigenesis, Genetic; Gene Expression Regulation; Genetic Predisposition to Disease; Germ Cells; Histones; Humans; Methylation; Neoplasms; Neurodegenerative Diseases; Obesity; Phenotype

2021
Effects of m6A modifications on signaling pathways in human cancer (Review).
    Oncology reports, 2021, Volume: 45, Issue:4

    Topics: Adenosine; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; RNA Processing, Post-Transcriptional; Signal Transduction

2021
Coordinated methyl readers: Functional communications in cancer.
    Seminars in cancer biology, 2022, Volume: 83

    Topics: Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms

2022
Roles of RNA Methylation on Tumor Immunity and Clinical Implications.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Animals; Humans; Immunity, Innate; Methylation; Neoplasms; RNA Splicing; RNA, Messenger; RNA, Neoplasm

2021
Posttranslational modification of pyruvate kinase type M2 (PKM2): novel regulation of its biological roles to be further discovered.
    Journal of physiology and biochemistry, 2021, Volume: 77, Issue:3

    Topics: Acetylation; Carrier Proteins; Cell Line, Tumor; Glycolysis; Humans; Membrane Proteins; Methylation; Neoplasms; Protein Processing, Post-Translational; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Warburg Effect, Oncologic

2021
N
    Cancer communications (London, England), 2021, Volume: 41, Issue:7

    Topics: Adenosine; Humans; Methylation; Neoplasms; RNA; RNA, Messenger

2021
Oncohistones: a roadmap to stalled development.
    The FEBS journal, 2022, Volume: 289, Issue:5

    Topics: Antineoplastic Agents; Carcinogenesis; Cell Differentiation; Chromatin; Complementary Therapies; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Molecular Targeted Therapy; Mutation; Neoplasms; Neoplastic Stem Cells; Oncogenes; Polycomb-Group Proteins; Protein Processing, Post-Translational

2022
Protein arginine methyltransferases: promising targets for cancer therapy.
    Experimental & molecular medicine, 2021, Volume: 53, Issue:5

    Topics: Antineoplastic Agents; Arginine; Biomarkers, Tumor; Cell Cycle; Disease Management; Disease Susceptibility; DNA Damage; Drug Development; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Methylation; Molecular Targeted Therapy; Neoplasms; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases

2021
Cancer synthetic vulnerabilities to protein arginine methyltransferase inhibitors.
    Current opinion in pharmacology, 2021, Volume: 59

    Topics: Arginine; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases

2021
Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer.
    International journal of molecular sciences, 2021, May-26, Volume: 22, Issue:11

    Topics: Humans; Methylation; NAD; Neoplasm Proteins; Neoplasms; Neoplastic Stem Cells; Niacinamide; Nicotinamide N-Methyltransferase

2021
Biochemical perspectives on targeting KMT2 methyltransferases in cancer.
    Trends in pharmacological sciences, 2021, Volume: 42, Issue:8

    Topics: DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Humans; Methylation; Myeloid-Lymphoid Leukemia Protein; Neoplasms

2021
Interactions between m6A modification and miRNAs in malignant tumors.
    Cell death & disease, 2021, 06-09, Volume: 12, Issue:6

    Topics: Adenosine; Animals; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; MicroRNAs; Neoplasms; RNA Processing, Post-Transcriptional

2021
m6A RNA methylation and beyond - The epigenetic machinery and potential treatment options.
    Drug discovery today, 2021, Volume: 26, Issue:11

    Topics: Epigenesis, Genetic; Epigenomics; Epithelial-Mesenchymal Transition; Gene Expression Profiling; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional; Stem Cells

2021
METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth.
    Protein & cell, 2021, Volume: 12, Issue:12

    Topics: Animals; Carrier Proteins; Histidine; Humans; Methylation; Methyltransferases; Neoplasm Proteins; Neoplasms; Protein Processing, Post-Translational

2021
The Emerging Roles of RNA m
    Cancer research, 2021, 07-01, Volume: 81, Issue:13

    Topics: Adenosine; Animals; Demethylation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; RNA

2021
Regulation of autophagy by protein methylation and acetylation in cancer.
    Journal of cellular physiology, 2022, Volume: 237, Issue:1

    Topics: Acetylation; Autophagy; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational

2022
RNA methylation in mammalian development and cancer.
    Cell biology and toxicology, 2021, Volume: 37, Issue:6

    Topics: Adenosine; Animals; Cell Differentiation; Methylation; Neoplasms; RNA

2021
Decoding m
    Cancer letters, 2021, 10-10, Volume: 518

    Topics: Adenosine; Animals; Gene Expression; Humans; Methylation; Neoplasms; Protein Domains; RNA Processing, Post-Transcriptional; RNA, Messenger

2021
CircRNAs and their regulatory roles in cancers.
    Molecular medicine (Cambridge, Mass.), 2021, 08-26, Volume: 27, Issue:1

    Topics: Animals; Biomarkers, Tumor; Disease Susceptibility; Gene Expression Regulation, Neoplastic; Humans; Methylation; MicroRNAs; Molecular Diagnostic Techniques; Neoplasms; Protein Biosynthesis; RNA Stability; RNA, Circular; RNA, Messenger; Transcription, Genetic

2021
Molecular Pathways: Metabolic Control of Histone Methylation and Gene Expression in Cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2017, Aug-01, Volume: 23, Issue:15

    Topics: Acetylation; Cell Transformation, Neoplastic; Chromatin; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Metabolic Networks and Pathways; Methylation; Neoplasms

2017
Arsenic metabolism and cancer risk: A meta-analysis.
    Environmental research, 2017, Volume: 156

    Topics: Arsenic; Environmental Pollutants; Humans; Methylation; Neoplasms; Odds Ratio; Risk

2017
One-carbon metabolism in cancer.
    British journal of cancer, 2017, Jun-06, Volume: 116, Issue:12

    Topics: Amino Acids; Carbon; Humans; Metabolic Networks and Pathways; Methylation; NAD; NADP; Neoplasms; Nucleotides

2017
Roles of RNA methylation by means of N
    Cancer letters, 2017, 11-01, Volume: 408

    Topics: Adenosine; Gene Expression Regulation; Humans; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional

2017
Structure, mechanism, and regulation of polycomb-repressive complex 2.
    The Journal of biological chemistry, 2018, 09-07, Volume: 293, Issue:36

    Topics: Animals; Crystallography, X-Ray; Gene Silencing; Humans; Methylation; Neoplasms; Polycomb Repressive Complex 2; Protein Conformation

2018
Regulation of poly(ADP-Ribose) polymerase 1 functions by post-translational modifications.
    Frontiers in bioscience (Landmark edition), 2018, 01-01, Volume: 23, Issue:1

    Topics: Acetylation; Animals; DNA Damage; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Protein Processing, Post-Translational

2018
Drug Discovery and Chemical Biology of Cancer Epigenetics.
    Cell chemical biology, 2017, Sep-21, Volume: 24, Issue:9

    Topics: Acetylation; DNA (Cytosine-5-)-Methyltransferases; Drug Discovery; Endosomal Sorting Complexes Required for Transport; Enzyme Inhibitors; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms

2017
Epigenetic mechanism of survivin dysregulation in human cancer.
    Science China. Life sciences, 2018, Volume: 61, Issue:7

    Topics: Acetylation; Antineoplastic Agents; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Neoplasms; Promoter Regions, Genetic; Survivin; Transcription Factors

2018
Epigenetic effects of metformin: From molecular mechanisms to clinical implications.
    Diabetes, obesity & metabolism, 2018, Volume: 20, Issue:7

    Topics: Acetylation; Animals; Anticarcinogenic Agents; Diabetes Complications; Diabetes Mellitus, Type 2; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Histones; Humans; Hypoglycemic Agents; Metformin; Methylation; MicroRNAs; Models, Biological; Neoplasms; Protein Processing, Post-Translational

2018
Multiple functions of m
    Journal of hematology & oncology, 2018, 03-27, Volume: 11, Issue:1

    Topics: Humans; Methylation; Neoplasms; RNA

2018
STAT3, stem cells, cancer stem cells and p63.
    Cellular & molecular biology letters, 2018, Volume: 23

    Topics: Animals; Cellular Reprogramming; Human Embryonic Stem Cells; Humans; Methylation; Mice; MicroRNAs; Mouse Embryonic Stem Cells; Neoplasms; Neoplastic Stem Cells; Phosphorylation; STAT3 Transcription Factor; Transcription Factors; Tumor Suppressor Proteins

2018
The Role of Dynamic m
    Photochemistry and photobiology, 2019, Volume: 95, Issue:1

    Topics: Adenosine; Circadian Clocks; DNA Damage; DNA Repair; Humans; Methylation; Neoplasms; RNA; Stem Cells; Ultraviolet Rays

2019
Mechanism of N
    Pharmacology & therapeutics, 2018, Volume: 189

    Topics: Adenosine; Animals; Histone Demethylases; Humans; Methylation; Methyltransferases; Neoplasms; RNA; RNA Editing

2018
Association between H3K4 methylation and cancer prognosis: A meta-analysis.
    Thoracic cancer, 2018, Volume: 9, Issue:7

    Topics: Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms; Prognosis; Protein Processing, Post-Translational

2018
RNA-modifying proteins as anticancer drug targets.
    Nature reviews. Drug discovery, 2018, Volume: 17, Issue:6

    Topics: Animals; Antineoplastic Agents; Humans; Methylation; Neoplasms; RNA; RNA, Messenger

2018
Radiation biology and oncology in the genomic era.
    The British journal of radiology, 2018, Volume: 91, Issue:1091

    Topics: Acetylation; Cytokines; DNA Methylation; Epigenesis, Genetic; Forecasting; Genetic Markers; Genomics; Histone Acetyltransferases; Humans; Medical Oncology; Methylation; Neoplasms; Precision Medicine; Radiation Tolerance; Radiobiology; Tumor Microenvironment

2018
KDM1A microenvironment, its oncogenic potential, and therapeutic significance.
    Epigenetics & chromatin, 2018, 06-19, Volume: 11, Issue:1

    Topics: Disease Progression; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Histone Demethylases; Histones; Humans; Methylation; Neoplasms; Tumor Microenvironment

2018
Methylation of RNA N
    Cytokine, 2019, Volume: 118

    Topics: Adenosine; Animals; Carcinogenesis; Cytokines; Humans; Methylation; Neoplasms; RNA

2019
Endometriosis.
    Nature reviews. Disease primers, 2018, 07-19, Volume: 4, Issue:1

    Topics: Adolescent; Adult; Endometriosis; Endometrium; Female; Humans; Methylation; Middle Aged; Neoplasms; Pain; Quality of Life

2018
The dual role of N6-methyladenosine modification of RNAs is involved in human cancers.
    Journal of cellular and molecular medicine, 2018, Volume: 22, Issue:10

    Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Carcinogenesis; Disease Progression; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genetic Therapy; Humans; Methylation; Methyltransferases; Molecular Targeted Therapy; Neoplasms; RNA Editing; RNA, Neoplasm

2018
Recognition of cancer mutations in histone H3K36 by epigenetic writers and readers.
    Epigenetics, 2018, Volume: 13, Issue:7

    Topics: Epigenomics; Histones; Humans; Methylation; Mutation; Neoplasms; Transcription, Genetic

2018
Metabolic Signaling to the Nucleus in Cancer.
    Molecular cell, 2018, 08-02, Volume: 71, Issue:3

    Topics: Acetylation; Animals; Carcinogenesis; Cell Nucleus; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation, Neoplastic; Histones; Humans; Metabolic Networks and Pathways; Methylation; Neoplasms; Nutrients; Nutrigenomics; Protein Processing, Post-Translational; Signal Transduction

2018
Epitranscriptomic Code and Its Alterations in Human Disease.
    Trends in molecular medicine, 2018, Volume: 24, Issue:10

    Topics: Cardiovascular Diseases; Congenital Abnormalities; Epigenesis, Genetic; High-Throughput Nucleotide Sequencing; Humans; Metabolic Diseases; Methylation; Mitochondrial Diseases; Neoplasms; Nervous System Diseases; Purine Nucleotides; Pyrimidine Nucleotides; RNA; RNA Processing, Post-Transcriptional; Transcriptome

2018
Aberrant Regulation of mRNA m⁶A Modification in Cancer Development.
    International journal of molecular sciences, 2018, Aug-25, Volume: 19, Issue:9

    Topics: Adenosine; Animals; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; Neoplasms; RNA, Messenger

2018
KDM5B is a master regulator of the H3K4-methylome in stem cells, development and cancer.
    Seminars in cancer biology, 2019, Volume: 57

    Topics: Biomarkers, Tumor; Cell Transformation, Neoplastic; Epigenesis, Genetic; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Neoplasms; Nuclear Proteins; Repressor Proteins; Stem Cells

2019
A dynamic reversible RNA N
    Journal of cellular physiology, 2019, Volume: 234, Issue:6

    Topics: Adenosine; Epigenesis, Genetic; Humans; Lipid Metabolism; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Messenger

2019
tRNA modification and cancer: potential for therapeutic prevention and intervention.
    Future medicinal chemistry, 2019, Volume: 11, Issue:8

    Topics: Animals; Codon; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; Oxidative Stress; RNA, Transfer; tRNA Methyltransferases

2019
RNA 2'-O-Methylation (Nm) Modification in Human Diseases.
    Genes, 2019, 02-05, Volume: 10, Issue:2

    Topics: Animals; Autoimmune Diseases; Epigenesis, Genetic; Humans; Methylation; Neoplasms; Nervous System Diseases; RNA; RNA Processing, Post-Transcriptional

2019
The role of m6A RNA methylation in cancer.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 112

    Topics: Adenosine; Animals; Humans; Methylation; Neoplasms; RNA

2019
Functions of RNA N6-methyladenosine modification in cancer progression.
    Molecular biology reports, 2019, Volume: 46, Issue:1

    Topics: Adenosine; Animals; Disease Progression; Humans; Methylation; Neoplasms; RNA

2019
Posttranslational regulation of PGC-1α and its implication in cancer metabolism.
    International journal of cancer, 2019, 09-15, Volume: 145, Issue:6

    Topics: Autophagy; Humans; Methylation; Mitochondria; Mitophagy; Neoplasms; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Protein Conformation; Protein Processing, Post-Translational; Signal Transduction

2019
Importance of m N
    Medical oncology (Northwood, London, England), 2019, Mar-16, Volume: 36, Issue:4

    Topics: Adenosine; Animals; DNA Damage; Humans; Methylation; Neoplasms; RNA, Neoplasm

2019
The Critical Role of RNA m
    Cancer research, 2019, 04-01, Volume: 79, Issue:7

    Topics: Adenosine; Demethylation; Humans; Methylation; Methyltransferases; Neoplasms; RNA; RNA-Binding Proteins

2019
Role of protein arginine methyltransferase 5 in human cancers.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 114

    Topics: Animals; Biomarkers, Tumor; Histones; Humans; Methylation; Neoplasms; Protein-Arginine N-Methyltransferases

2019
Functions of RNA N6-methyladenosine modification in cancer progression.
    Molecular biology reports, 2019, Volume: 46, Issue:2

    Topics: Adenosine; Disease Progression; Humans; Methylation; Methyltransferases; Neoplasms; RNA; RNA Processing, Post-Transcriptional

2019
Lysine methylation of transcription factors in cancer.
    Cell death & disease, 2019, 03-29, Volume: 10, Issue:4

    Topics: Antineoplastic Agents; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplasms; Protein Processing, Post-Translational; Protein Stability; Transcription Factors

2019
Detection of N6‑methyladenosine modification residues (Review).
    International journal of molecular medicine, 2019, Volume: 43, Issue:6

    Topics: Adenosine; Animals; Biosensing Techniques; Blotting, Northern; Chromatography, High Pressure Liquid; Electrochemical Techniques; Humans; Immunoblotting; Immunoprecipitation; Methylation; Neoplasms; RNA; Sequence Analysis, RNA

2019
A Review in Research Progress Concerning m6A Methylation and Immunoregulation.
    Frontiers in immunology, 2019, Volume: 10

    Topics: Active Transport, Cell Nucleus; Adenosine; Humans; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional; RNA Splicing; RNA, Messenger

2019
Understanding histone H3 lysine 36 methylation and its deregulation in disease.
    Cellular and molecular life sciences : CMLS, 2019, Volume: 76, Issue:15

    Topics: DNA Modification Methylases; DNA Repair; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Neoplasms; Neurodevelopmental Disorders; RNA Splicing

2019
Epigenetic Modification in Macrophages: A Promising Target for Tumor and Inflammation-associated Disease Therapy.
    Current topics in medicinal chemistry, 2019, Volume: 19, Issue:15

    Topics: Acetylation; Animals; Antineoplastic Agents; DNA Methylation; Epigenesis, Genetic; Histones; Humans; Inflammation; Macrophages; Methylation; Neoplasms

2019
PRMTs and Arginine Methylation: Cancer's Best-Kept Secret?
    Trends in molecular medicine, 2019, Volume: 25, Issue:11

    Topics: Animals; Antineoplastic Agents; Arginine; DNA Damage; Drug Resistance; Epigenomics; Histones; Humans; Immunotherapy; Methylation; Mice; Molecular Targeted Therapy; Neoplasms; Protein Processing, Post-Translational; Protein Splicing; Protein-Arginine N-Methyltransferases; RNA Splicing; Stem Cells

2019
PRMTs and miRNAs: functional cooperation in cancer and beyond.
    Cell cycle (Georgetown, Tex.), 2019, Volume: 18, Issue:15

    Topics: 3' Untranslated Regions; Arginine; Cardiovascular Diseases; Epigenesis, Genetic; Histones; Humans; Inflammation; Methylation; MicroRNAs; Neoplasms; Neurodegenerative Diseases; Peptide Chain Initiation, Translational; Protein Binding; Protein-Arginine N-Methyltransferases

2019
The importance of non-histone protein methylation in cancer therapy.
    Nature reviews. Molecular cell biology, 2019, Volume: 20, Issue:10

    Topics: Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Enzyme Inhibitors; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational

2019
New discoveries of mdig in the epigenetic regulation of cancers.
    Seminars in cancer biology, 2019, Volume: 57

    Topics: Animals; Biomarkers, Tumor; Cell Cycle; Dioxygenases; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genetic Association Studies; Genetic Predisposition to Disease; Histone Demethylases; Histones; Humans; Methylation; Neoplasms; Neoplastic Stem Cells; Nuclear Proteins; Prognosis

2019
The regulation, functions and clinical relevance of arginine methylation.
    Nature reviews. Molecular cell biology, 2019, Volume: 20, Issue:10

    Topics: Animals; Arginine; Humans; Methylation; Neoplasm Proteins; Neoplasms; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Signal Transduction

2019
Histone methyltransferase SMYD2: ubiquitous regulator of disease.
    Clinical epigenetics, 2019, 08-01, Volume: 11, Issue:1

    Topics: Cardiovascular Diseases; Epigenesis, Genetic; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Molecular Targeted Therapy; Neoplasms

2019
Context-specific regulation of cancer epigenomes by histone and transcription factor methylation.
    Oncogene, 2014, Mar-06, Volume: 33, Issue:10

    Topics: Chromatin; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational; Transcription Factors

2014
Regulation of chromatin structure via histone post-translational modification and the link to carcinogenesis.
    Cancer metastasis reviews, 2013, Volume: 32, Issue:3-4

    Topics: Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; DNA Repair; Gene Expression Regulation, Neoplastic; Genes, Immediate-Early; Genomic Instability; Histone Demethylases; Histones; Humans; Interphase; Methylation; Mitosis; Neoplasms; Phosphorylation; Prognosis; Protein Processing, Post-Translational; Transcriptome; Ubiquitination

2013
Drugging the human methylome: an emerging modality for reversible control of aberrant gene transcription.
    Current opinion in chemical biology, 2013, Volume: 17, Issue:3

    Topics: Amino Acid Sequence; Animals; Drug Discovery; Humans; Methylation; Molecular Sequence Data; Neoplasms; Proteins; Transcription, Genetic

2013
Defining the RGG/RG motif.
    Molecular cell, 2013, Jun-06, Volume: 50, Issue:5

    Topics: Alternative Splicing; Amino Acid Motifs; Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Apoptosis; Arginine; DNA Damage; Fragile X Syndrome; Humans; Methylation; Molecular Sequence Data; Neoplasms; Neuromuscular Diseases; Protein Biosynthesis; Protein Interaction Domains and Motifs; Proteins

2013
Serine, glycine and one-carbon units: cancer metabolism in full circle.
    Nature reviews. Cancer, 2013, Volume: 13, Issue:8

    Topics: Epigenesis, Genetic; Glycine; Humans; Methylation; Neoplasms; Oxidation-Reduction; Serine

2013
Advances in understanding the coupling of DNA base modifying enzymes to processes involving base excision repair.
    Advances in cancer research, 2013, Volume: 119

    Topics: 5-Methylcytosine; Animals; Cell Differentiation; DNA; DNA Damage; DNA Glycosylases; DNA Methylation; DNA Repair; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms; Purines; Pyrimidines

2013
Decoding the histone code: Role of H3K36me3 in mismatch repair and implications for cancer susceptibility and therapy.
    Cancer research, 2013, Nov-01, Volume: 73, Issue:21

    Topics: Base Pair Mismatch; Histone Code; Humans; Lysine; Methylation; Neoplasms; Polycomb Repressive Complex 2

2013
The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 2013, Volume: 91, Issue:6

    Topics: Animals; Cell Cycle; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; Drosophila melanogaster; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histones; Humans; Isoenzymes; Methylation; Mice; Mice, Transgenic; Neoplasms; Signal Transduction

2013
Mutant TP53 posttranslational modifications: challenges and opportunities.
    Human mutation, 2014, Volume: 35, Issue:6

    Topics: Acetylation; Gene Expression Regulation, Neoplastic; Humans; Methylation; Mutation; Neoplasms; Phosphorylation; Signal Transduction; Tumor Suppressor Protein p53; Ubiquitination

2014
The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle.
    Cell cycle (Georgetown, Tex.), 2014, Volume: 13, Issue:5

    Topics: Animals; Cell Cycle; Cellular Reprogramming; Chromatin; DNA Damage; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms

2014
Chromatin dynamics: H3K4 methylation and H3 variant replacement during development and in cancer.
    Cellular and molecular life sciences : CMLS, 2014, Volume: 71, Issue:18

    Topics: Amino Acid Sequence; Chromatin; Chromatin Assembly and Disassembly; Epigenomics; Gene Expression Regulation; Genetic Variation; Genome; Histones; Humans; Methylation; Models, Genetic; Molecular Sequence Data; Neoplasms; Sequence Alignment

2014
Examining the impact of gene variants on histone lysine methylation.
    Biochimica et biophysica acta, 2014, Volume: 1839, Issue:12

    Topics: Animals; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mutation; Neoplasms; Polymorphism, Single Nucleotide

2014
Mechanism and function of oxidative reversal of DNA and RNA methylation.
    Annual review of biochemistry, 2014, Volume: 83

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA; DNA Methylation; Escherichia coli; Gene Expression Regulation; Genome; Germ Cells; HEK293 Cells; Humans; Methylation; Mice; Neoplasms; Oxygen; RNA; Stem Cells; Transcriptome

2014
The deep end of the metabolite pool: influences on epigenetic regulatory mechanisms in cancer.
    European journal of clinical investigation, 2015, Volume: 45 Suppl 1

    Topics: Acetylation; Acetylglucosamine; Citric Acid Cycle; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glycosylation; Histones; Humans; Methylation; Neoplasms; S-Adenosylmethionine; Uridine Diphosphate

2015
Targeting histone lysine methylation in cancer.
    Pharmacology & therapeutics, 2015, Volume: 150

    Topics: Animals; Antineoplastic Agents; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Molecular Targeted Therapy; Neoplasms; Signal Transduction

2015
The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond.
    Cellular and molecular life sciences : CMLS, 2015, Volume: 72, Issue:11

    Topics: Adaptor Proteins, Signal Transducing; Arginine; Catalytic Domain; Cell Differentiation; Gene Expression Regulation; Histones; Humans; Methylation; Multiprotein Complexes; Neoplasms; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Quaternary; Protein-Arginine N-Methyltransferases

2015
Fibrillarin from Archaea to human.
    Biology of the cell, 2015, Volume: 107, Issue:6

    Topics: Animals; Archaea; Chromosomal Proteins, Non-Histone; Humans; Methylation; Neoplasms

2015
Epigenetic regulation by histone demethylases in hypoxia.
    Epigenomics, 2015, Volume: 7, Issue:5

    Topics: Cardiovascular Diseases; Epigenesis, Genetic; Histones; Humans; Hypoxia; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Models, Genetic; Neoplasms

2015
The NSD family of protein methyltransferases in human cancer.
    Epigenomics, 2015, Volume: 7, Issue:5

    Topics: Antineoplastic Agents; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Methylation; Molecular Targeted Therapy; Mutation; Neoplasms; Nuclear Proteins; Repressor Proteins

2015
[Development of novel epigenetic molecular-targeting agents].
    Nihon rinsho. Japanese journal of clinical medicine, 2015, Volume: 73, Issue:8

    Topics: Acetylation; Antineoplastic Agents; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA, Neoplasm; Drug Discovery; Enzyme Inhibitors; Epigenesis, Genetic; Fusion Proteins, bcr-abl; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone Demethylases; Histones; Humans; Methylation; Molecular Targeted Therapy; Mutation; Neoplasms; Oncogenes; Protein Kinase Inhibitors

2015
PRC2 mediated H3K27 methylations in cellular identity and cancer.
    Current opinion in cell biology, 2015, Volume: 37

    Topics: Animals; Cell Differentiation; Cell Lineage; Histones; Humans; Methylation; Neoplasms; Polycomb Repressive Complex 2

2015
Posttranscriptional methylation of transfer and ribosomal RNA in stress response pathways, cell differentiation, and cancer.
    Current opinion in oncology, 2016, Volume: 28, Issue:1

    Topics: Cell Differentiation; Cytidine; Cytosine; Humans; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Ribosomal; Stress, Physiological

2016
N6-methyladenosine modification in mRNA: machinery, function and implications for health and diseases.
    The FEBS journal, 2016, Volume: 283, Issue:9

    Topics: Adenosine; Cell Differentiation; Eukaryotic Cells; Humans; Methylation; Methyltransferases; Neoplasms; Neurodegenerative Diseases; Oxidoreductases, N-Demethylating; RNA Splicing; RNA, Long Noncoding; RNA, Messenger; Signal Transduction; Transcription, Genetic

2016
Dysregulation of protein methyltransferases in human cancer: An emerging target class for anticancer therapy.
    Cancer science, 2016, Volume: 107, Issue:4

    Topics: Antineoplastic Agents; Epigenesis, Genetic; Histones; Humans; Methylation; Molecular Targeted Therapy; Neoplasms; Protein Methyltransferases; Protein Processing, Post-Translational

2016
Enhancement of anticancer potential of polyphenols by covalent modifications.
    Biochemical pharmacology, 2016, 06-01, Volume: 109

    Topics: Acetylation; Acylation; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Hydroxylation; Methylation; Neoplasm Proteins; Neoplasms; Neovascularization, Pathologic; Polyphenols; Structure-Activity Relationship

2016
Small Molecular Inhibitors Targeting Chromatin Regulating Proteins for Cancer.
    Current protein & peptide science, 2016, Volume: 17, Issue:5

    Topics: Acetylation; Animals; Antineoplastic Agents; Chromatin; Chromatin Assembly and Disassembly; Drug Discovery; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Methylation; Molecular Targeted Therapy; Neoplasms; Nuclear Proteins; Nucleoproteins

2016
Histone Modifications and Cancer.
    Cold Spring Harbor perspectives in biology, 2016, Apr-01, Volume: 8, Issue:4

    Topics: Acetylation; Chromatin Assembly and Disassembly; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Code; Histones; Methylation; Neoplasms

2016
Give it or take it: the flux of one-carbon in cancer cells.
    The FEBS journal, 2016, Volume: 283, Issue:20

    Topics: Animals; Carbon; Carbon Cycle; Cell Compartmentation; Cytosol; Embryonic Development; Glycine; Humans; Metabolic Networks and Pathways; Methylation; Mitochondria; Models, Biological; Neoplasms; Serine

2016
TCPs: privileged scaffolds for identifying potent LSD1 inhibitors for cancer therapy.
    Epigenomics, 2016, Volume: 8, Issue:5

    Topics: Animals; Antineoplastic Agents; Drug Design; Gene Expression Regulation, Neoplastic; Histone Demethylases; Humans; Methylation; Molecular Targeted Therapy; Neoplasms; Protein Processing, Post-Translational; Structure-Activity Relationship; Tranylcypromine

2016
Epigenetic balance of gene expression by Polycomb and COMPASS families.
    Science (New York, N.Y.), 2016, Jun-03, Volume: 352, Issue:6290

    Topics: Animals; Chromatin; Chromosomal Proteins, Non-Histone; Drosophila melanogaster; Embryonic Development; Enhancer Elements, Genetic; Epigenesis, Genetic; Gene Expression; Growth and Development; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Mutation; Neoplasms; Polycomb-Group Proteins; Saccharomyces cerevisiae

2016
Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.
    Molecular cell, 2016, 06-02, Volume: 62, Issue:5

    Topics: Animals; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Models, Molecular; Mutation; Neoplasms; Nucleic Acid Conformation; Oncogenes; Phosphorylation; Protein Binding; Protein Conformation; Structure-Activity Relationship; Transcription, Genetic

2016
Histone demethylase LSD1 controls the phenotypic plasticity of cancer cells.
    Cancer science, 2016, Volume: 107, Issue:9

    Topics: Animals; Cell Transformation, Neoplastic; Energy Metabolism; Epigenesis, Genetic; Gene Expression Regulation, Leukemic; Histone Demethylases; Histones; Humans; Methylation; Neoplasms; Phenotype

2016
Writers and Erasers of Histone Lysine methylation with Clinically Applied Modulators: Promising Target for Cancer Therapy.
    Current pharmaceutical design, 2016, Volume: 22, Issue:39

    Topics: Antineoplastic Agents; Histones; Humans; Lysine; Methylation; Neoplasms

2016
[Methionine metabolism regulates biotransformation of glucose via protein arginine methylation in cancer cells].
    Seikagaku. The Journal of Japanese Biochemical Society, 2016, Volume: 88, Issue:3

    Topics: Animals; Arginine; Glucose; Humans; Methionine; Methylation; Neoplasms; Proteins

2016
Protein arginine methylation/demethylation and cancer.
    Oncotarget, 2016, Oct-11, Volume: 7, Issue:41

    Topics: Arginine; Demethylation; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Neoplasms; Protein Processing, Post-Translational

2016
Nonhistone Lysine Methylation in the Regulation of Cancer Pathways.
    Cold Spring Harbor perspectives in medicine, 2016, Nov-01, Volume: 6, Issue:11

    Topics: Cell Transformation, Neoplastic; Chromosomal Proteins, Non-Histone; DNA Damage; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Neoplasms; Protein Processing, Post-Translational; Signal Transduction

2016
Folylpoly-γ-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer.
    Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 2016, Volume: 28

    Topics: Animals; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Homeostasis; Humans; Methylation; Mice; Neoplasms; Peptide Synthases; Polyglutamic Acid; S-Adenosylmethionine; Signal Transduction

2016
Cancer metabolism at a glance.
    Journal of cell science, 2016, 09-15, Volume: 129, Issue:18

    Topics: Animals; Fatty Acids; Humans; Metabolic Networks and Pathways; Metabolome; Methylation; Neoplasms; Reactive Oxygen Species

2016
MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer.
    Cold Spring Harbor perspectives in medicine, 2016, Nov-01, Volume: 6, Issue:11

    Topics: Animals; Cell Transformation, Neoplastic; DNA-Binding Proteins; Enhancer Elements, Genetic; Epigenesis, Genetic; Gene Expression; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Mice; Neoplasms; Protein Processing, Post-Translational

2016
Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1.
    Biochemical Society transactions, 2016, 12-15, Volume: 44, Issue:6

    Topics: Animals; Carboxylic Ester Hydrolases; Humans; Methylation; Models, Biological; Neoplasms; Phosphorylation; Protein Phosphatase 2; Signal Transduction; Tumor Suppressor Proteins

2016
The story of protein arginine methylation: characterization, regulation, and function.
    Expert review of proteomics, 2017, Volume: 14, Issue:2

    Topics: Arginine; Cardiovascular Diseases; DNA Repair; Humans; Mass Spectrometry; Methylation; Multiple Sclerosis; Muscular Atrophy, Spinal; Neoplasms; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Proteins; Proteomics; Signal Transduction

2017
Histone Lysine Demethylase Inhibitors.
    Cold Spring Harbor perspectives in medicine, 2017, Jan-03, Volume: 7, Issue:1

    Topics: Animals; Enzyme Inhibitors; Histone Demethylases; Histones; Humans; Methylation; Mice; Neoplasms; Structure-Activity Relationship

2017
Epigenetics in cancer stem cells.
    Molecular cancer, 2017, 02-01, Volume: 16, Issue:1

    Topics: Acetylation; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Epigenomics; Histones; Humans; Methylation; Neoplasm Metastasis; Neoplasms; Neoplastic Stem Cells; Signal Transduction

2017
Clinical and biological effects of demethylating agents on solid tumours - A systematic review.
    Cancer treatment reviews, 2017, Volume: 54

    Topics: Antimetabolites, Antineoplastic; Azacitidine; Cytidine; Decitabine; DNA Methylation; Humans; Hydralazine; Immune System; Methylation; Neoplasms; Procaine; Treatment Outcome

2017
[Role of Histone Methylation in Myeloid Malignancies -Review].
    Zhongguo shi yan xue ye xue za zhi, 2017, Volume: 25, Issue:1

    Topics: Epigenesis, Genetic; Histones; Methylation; Neoplasms

2017
Regulatory Role of N
    Journal of cellular biochemistry, 2017, Volume: 118, Issue:9

    Topics: Adenosine; Animals; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Humans; Methylation; Neoplasms; Obesity; RNA Processing, Post-Transcriptional; RNA, Neoplasm

2017
Epigenetic Control of Autophagy: Nuclear Events Gain More Attention.
    Molecular cell, 2017, Mar-02, Volume: 65, Issue:5

    Topics: Acetylation; Animals; Autophagy; Cell Nucleus; Chromatin; Chromatin Assembly and Disassembly; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms; Protein Methyltransferases

2017
A saga of cancer epigenetics: linking epigenetics to alternative splicing.
    The Biochemical journal, 2017, 03-07, Volume: 474, Issue:6

    Topics: Acetylation; Alternative Splicing; Disease Progression; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Neoplasms; RNA Polymerase II; RNA-Binding Proteins; Transcription Elongation, Genetic

2017
High mobility group proteins and their post-translational modifications.
    Biochimica et biophysica acta, 2008, Volume: 1784, Issue:9

    Topics: Acetylation; Active Transport, Cell Nucleus; Amino Acid Sequence; Animals; High Mobility Group Proteins; Histones; Humans; Methylation; Models, Molecular; Molecular Sequence Data; Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Protein Structure, Tertiary

2008
Can folate intake reduce arsenic toxicity?
    Nutrition reviews, 2008, Volume: 66, Issue:6

    Topics: Arsenic; Arsenic Poisoning; Environmental Exposure; Folic Acid; Humans; Methylation; Neoplasms; Risk Factors; Vitamin B Complex

2008
Protein arginine methylation in health and disease.
    Biotechnology annual review, 2008, Volume: 14

    Topics: Animals; Arginine; Autoimmune Diseases; Cardiovascular Diseases; Humans; Methylation; Models, Biological; Neoplasms; Virus Diseases

2008
Transcription-independent functions of MYC: regulation of translation and DNA replication.
    Nature reviews. Molecular cell biology, 2008, Volume: 9, Issue:10

    Topics: Animals; DNA Replication; Genes, myc; Humans; Methylation; Models, Biological; Models, Genetic; Neoplasms; Protein Biosynthesis; Proto-Oncogene Proteins c-myc; RNA Caps; RNA, Messenger; Transcription Factors

2008
Dynamic protein methylation in chromatin biology.
    Cellular and molecular life sciences : CMLS, 2009, Volume: 66, Issue:3

    Topics: Animals; Arginine; Chromatin; DNA Damage; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Regulation; Germ Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Models, Molecular; Molecular Structure; Neoplasms; Oxidoreductases, N-Demethylating; Protein Conformation; Protein Methyltransferases; Protein Processing, Post-Translational; Tumor Suppressor Protein p53

2009
The critical role of the class III histone deacetylase SIRT1 in cancer.
    Cancer research, 2009, Mar-01, Volume: 69, Issue:5

    Topics: Acetylation; Animals; Apoptosis; Cell Proliferation; CpG Islands; DNA Methylation; Enzyme Inhibitors; Genes, Tumor Suppressor; Histones; Humans; Methylation; Neoplasms; Oncogenes; RNA, Messenger; Sirtuin 1; Sirtuins

2009
[Histone modification: a new era of targeting epigenetics].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2009, Volume: 50, Issue:4

    Topics: Acetylation; Animals; Chromatin; DNA; Drug Discovery; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms; Phosphorylation

2009
The physiological and pathophysiological role of PRMT1-mediated protein arginine methylation.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Animals; DNA Methylation; Heart Diseases; Humans; Kidney Diseases; Methylation; Neoplasms; Protein-Arginine N-Methyltransferases; Repressor Proteins

2009
The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors.
    ChemMedChem, 2009, Volume: 4, Issue:10

    Topics: Arginine; Enzyme Inhibitors; Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplasms; Protein Processing, Post-Translational

2009
Towards targeted epigenetic therapy of cancer.
    Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 2009, Volume: 14 Suppl 1

    Topics: Acetylation; DNA Modification Methylases; Epigenesis, Genetic; Genetic Therapy; Histones; Humans; Methylation; MicroRNAs; Mutation; Neoplasms; Pharmacogenetics

2009
Protein arginine methylation in estrogen signaling and estrogen-related cancers.
    Trends in endocrinology and metabolism: TEM, 2010, Volume: 21, Issue:3

    Topics: Animals; Arginine; Breast Neoplasms; Estrogens; Female; Humans; Male; Methylation; Models, Biological; Neoplasms; Protein-Arginine N-Methyltransferases; Receptors, Estrogen; Signal Transduction

2010
[Current situation researching of methylation in tumor].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2009, Volume: 31, Issue:6

    Topics: DNA Methylation; Histones; Humans; Methylation; Neoplasms

2009
Methylation of dietary flavones increases their metabolic stability and chemopreventive effects.
    International journal of molecular sciences, 2009, Nov-18, Volume: 10, Issue:11

    Topics: Animals; Cell Membrane Permeability; Diet; Flavones; Half-Life; Humans; Methylation; Microsomes, Liver; Neoplasms

2009
Viral epigenomes in human tumorigenesis.
    Oncogene, 2010, Mar-11, Volume: 29, Issue:10

    Topics: CpG Islands; DNA Methylation; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms; Viral Proteins; Virus Diseases; Viruses

2010
Epigenetic changes in the myelodysplastic syndrome.
    Hematology/oncology clinics of North America, 2010, Volume: 24, Issue:2

    Topics: Acetylation; Acute Disease; Azacitidine; Cell Transformation, Neoplastic; Decitabine; DNA Methylation; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Leukemia, Myeloid; Methylation; Myelodysplastic Syndromes; Neoplasms; Protein Processing, Post-Translational

2010
Epigenetic alterations in aging.
    Journal of applied physiology (Bethesda, Md. : 1985), 2010, Volume: 109, Issue:2

    Topics: Acetylation; Age Factors; Aging; Aging, Premature; Animals; Chromatin Assembly and Disassembly; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Neoplasms; RNA, Untranslated

2010
Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers.
    Nature reviews. Cancer, 2010, Volume: 10, Issue:7

    Topics: Animals; Histones; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational

2010
Cancer in experimental animals exposed to arsenic and arsenic compounds.
    Critical reviews in toxicology, 2010, Volume: 40, Issue:10

    Topics: Animals; Arsenic; Arsenicals; Carcinogens; Disease Models, Animal; Female; Humans; Male; Methylation; Mice; Mice, Inbred Strains; Neoplasms; Rats; Rats, Inbred Strains

2010
[Disease and epigenome analysis].
    Seikagaku. The Journal of Japanese Biochemical Society, 2010, Volume: 82, Issue:8

    Topics: Acetylation; Animals; Cell Transformation, Neoplastic; Chromatin; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genomics; Histones; Humans; Life Style; Mental Disorders; Methylation; Neoplasms; Neoplastic Stem Cells

2010
Organoarsenicals. Uptake, metabolism, and toxicity.
    Metal ions in life sciences, 2010, Volume: 7

    Topics: Animals; Arsenicals; Carcinogens; DNA Damage; Environmental Exposure; Humans; Methylation; Neoplasms; Organometallic Compounds; Water Pollutants, Chemical

2010
Inheritance of epigenetic aberrations (constitutional epimutations) in cancer susceptibility.
    Advances in genetics, 2010, Volume: 70

    Topics: Adaptor Proteins, Signal Transducing; Agouti Signaling Protein; alpha-Thalassemia; Animals; Biomarkers, Tumor; Colorectal Neoplasms, Hereditary Nonpolyposis; DNA Mismatch Repair; Epigenesis, Genetic; Female; Gene Silencing; Genes, Tumor Suppressor; Genetic Predisposition to Disease; Humans; Linaria; Male; Methylation; Mice; MicroRNAs; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasms; Nuclear Proteins; Polymorphism, Single Nucleotide

2010
Histone modification therapy of cancer.
    Advances in genetics, 2010, Volume: 70

    Topics: Acetylation; Animals; Antineoplastic Agents; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Methylation; Methyltransferases; Neoplasms; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases

2010
p53 post-translational modification: deregulated in tumorigenesis.
    Trends in molecular medicine, 2010, Volume: 16, Issue:11

    Topics: Acetylation; Animals; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Tumor Suppressor Protein p53; Ubiquitination

2010
Errors in erasure: links between histone lysine methylation removal and disease.
    Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 2011, Volume: 67

    Topics: Animals; Cathepsin L; Cell Cycle Proteins; Histone Chaperones; Histone Demethylases; Histones; Humans; Lysine; Methylation; Neoplasms; Transcription Factors

2011
Epigenetic cancer therapy: Proof of concept and remaining challenges.
    BioEssays : news and reviews in molecular, cellular and developmental biology, 2010, Volume: 32, Issue:11

    Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Molecular Targeted Therapy; Neoplasms

2010
The Polycomb complex PRC2 and its mark in life.
    Nature, 2011, Jan-20, Volume: 469, Issue:7330

    Topics: Animals; Cell Differentiation; Chromatin; Evolution, Molecular; Genome; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Neoplasms; Polycomb-Group Proteins; Repressor Proteins

2011
Histone onco-modifications.
    Oncogene, 2011, Aug-04, Volume: 30, Issue:31

    Topics: Acetylation; Cell Transformation, Neoplastic; Chromatin; DNA Repair; Epigenesis, Genetic; Gene Silencing; Histones; Humans; Methylation; Neoplasms; Oncogene Proteins; Protein Processing, Post-Translational

2011
Epigenetics, development, and cancer: zebrafish make their mark..
    Birth defects research. Part C, Embryo today : reviews, 2011, Volume: 93, Issue:2

    Topics: Acetylation; Animals; DNA Methylation; Embryonic Development; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Histones; Liver; Methylation; Models, Animal; Neoplasms; Zebrafish

2011
PRDM proteins: important players in differentiation and disease.
    BioEssays : news and reviews in molecular, cellular and developmental biology, 2012, Volume: 34, Issue:1

    Topics: Adipose Tissue, Brown; Animals; Blood Vessels; Cell Differentiation; Gene Expression Regulation; Hematologic Neoplasms; Hematopoiesis; Histones; Humans; Isoenzymes; Methylation; Mice; Mice, Transgenic; Neoplasms; Organ Specificity; Protein Methyltransferases; Signal Transduction; Transcription, Genetic; Tumor Suppressor Proteins

2012
Alterations in histone H4 lysine 20 methylation: implications for cancer detection and prevention.
    Antioxidants & redox signaling, 2012, Jul-15, Volume: 17, Issue:2

    Topics: Animals; Epigenesis, Genetic; Epigenomics; Histones; Humans; Lysine; Methylation; Neoplasms

2012
Carbon monoxide: impact on remethylation/transsulfuration metabolism and its pathophysiologic implications.
    Journal of molecular medicine (Berlin, Germany), 2012, Volume: 90, Issue:3

    Topics: Carbon Monoxide; Cystathionine beta-Synthase; Heme Oxygenase (Decyclizing); Humans; Hydrogen Sulfide; Methylation; Myocardial Ischemia; Neoplasms; Sulfur

2012
Histone methylation: a dynamic mark in health, disease and inheritance.
    Nature reviews. Genetics, 2012, Apr-03, Volume: 13, Issue:5

    Topics: Animals; Caenorhabditis; Drosophila; Epigenesis, Genetic; Female; Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Male; Methylation; Mice; Neoplasms; Protein Processing, Post-Translational; Rats

2012
Molecular mechanisms and potential functions of histone demethylases.
    Nature reviews. Molecular cell biology, 2012, Apr-04, Volume: 13, Issue:5

    Topics: Animals; Chromatin; Gene Expression Regulation; Histone Demethylases; Histones; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational; Protein Structure, Tertiary; Substrate Specificity

2012
Mechanistic links between ATM and histone methylation codes during DNA repair.
    Progress in molecular biology and translational science, 2012, Volume: 110

    Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; DNA Repair; DNA-Binding Proteins; Histone Code; Histones; Humans; Methylation; Neoplasms; Protein Serine-Threonine Kinases; Tumor Suppressor Proteins

2012
Oncoepigenomics: making histone lysine methylation count.
    European journal of medicinal chemistry, 2012, Volume: 56

    Topics: Animals; Epigenomics; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplasms

2012
Redox regulation of the epigenetic landscape in cancer: a role for metabolic reprogramming in remodeling the epigenome.
    Free radical biology & medicine, 2012, Dec-01, Volume: 53, Issue:11

    Topics: Acetylation; Animals; Carbohydrate Metabolism; Epigenesis, Genetic; Epigenomics; Genome, Human; Histones; Humans; Methylation; Neoplasms; Oxidation-Reduction; Protein Processing, Post-Translational

2012
Tipping the lysine methylation balance in disease.
    Biopolymers, 2013, Volume: 99, Issue:2

    Topics: Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Mutation; Neoplasms; Nervous System Diseases

2013
The methylation landscape of tumour metastasis.
    Biology of the cell, 2013, Volume: 105, Issue:2

    Topics: Animals; DNA Methylation; Epigenomics; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Neoplasm Metastasis; Neoplasms

2013
Histone methyltransferases, diet nutrients and tumour suppressors.
    Nature reviews. Cancer, 2002, Volume: 2, Issue:6

    Topics: Amino Acid Sequence; Diet; Folic Acid Deficiency; Forecasting; Genes, Tumor Suppressor; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Methionine; Methylation; Methyltransferases; Molecular Sequence Data; Neoplasms; Protein Methyltransferases; Sequence Homology, Amino Acid

2002
Senescence and epigenetic dysregulation in cancer.
    The international journal of biochemistry & cell biology, 2002, Volume: 34, Issue:11

    Topics: Animals; Cell Cycle; Cellular Senescence; DNA; Genes, Tumor Suppressor; Histone Deacetylases; Histones; Humans; Methylation; Neoplasms; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Telomerase; Telomere

2002
Methods for the molecular analysis of cancer. An overview.
    Molecular biotechnology, 2003, Volume: 23, Issue:2

    Topics: Animals; DNA Mutational Analysis; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization, Fluorescence; Methylation; Mutation; Neoplasms; Oligonucleotide Array Sequence Analysis; Sequence Analysis, DNA; Sequence Analysis, RNA; Telomerase

2003
News and views on folate and elderly persons.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2003, Volume: 58, Issue:4

    Topics: Aged; Cardiovascular Diseases; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Mental Disorders; Methylation; Neoplasms; Risk Factors; Vitamin B 12 Deficiency

2003
Folate and cancer: a review of the literature.
    Nutrition and cancer, 1994, Volume: 22, Issue:2

    Topics: Animals; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Humans; Methylation; Neoplasms; Risk Factors

1994
Drug methylation in cancer therapy: lessons from the TPMT polymorphism.
    Oncogene, 2003, Oct-20, Volume: 22, Issue:47

    Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Evolution, Molecular; Humans; Methylation; Methyltransferases; Molecular Sequence Data; Neoplasms; Pharmacogenetics; Polymorphism, Genetic

2003
Folate, methyl-related nutrients, alcohol, and the MTHFR 677C-->T polymorphism affect cancer risk: intake recommendations.
    The Journal of nutrition, 2003, Volume: 133, Issue:11 Suppl 1

    Topics: Adenoma; Alcohol Drinking; Colonic Neoplasms; Folic Acid; Humans; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mutation, Missense; Neoplasms; Nutrition Policy; Polymorphism, Single Nucleotide; Risk Factors; Vitamin B 12

2003
Histone modification enzymes: novel targets for cancer drugs.
    Expert opinion on emerging drugs, 2004, Volume: 9, Issue:1

    Topics: Acetylation; Acetyltransferases; Antineoplastic Agents; Chromatin; Clinical Trials as Topic; Drug Design; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Acetyltransferases; Histone Deacetylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Methylation; Multicenter Studies as Topic; Neoplasm Proteins; Neoplasms; Phosphorylation; Protamine Kinase; Protein Methyltransferases; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Tyrosine Phosphatases

2004
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.
    FEBS letters, 2004, Sep-10, Volume: 574, Issue:1-3

    Topics: Acetylation; Amino Acid Sequence; Apoptosis; Cell Transformation, Neoplastic; Chromatin; High Mobility Group Proteins; Methylation; Molecular Sequence Data; Neoplasms; Protein Conformation; Sequence Homology, Amino Acid

2004
Histone modifications as a platform for cancer therapy.
    Journal of cellular biochemistry, 2005, Apr-15, Volume: 94, Issue:6

    Topics: Chromatin; DNA Methylation; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histones; Humans; Methylation; Mitogen-Activated Protein Kinases; Neoplasms; Phosphorylation; Signal Transduction

2005
PTHrP gene expression in cancer: do all paths lead to Ets?
    Critical reviews in eukaryotic gene expression, 2005, Volume: 15, Issue:2

    Topics: Base Sequence; Bone Neoplasms; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Methylation; Mitogen-Activated Protein Kinase Kinases; Neoplasms; Parathyroid Hormone-Related Protein; Promoter Regions, Genetic; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Transcription Factors; Transforming Growth Factor beta; Vitamin D

2005
Linking covalent histone modifications to epigenetics: the rigidity and plasticity of the marks.
    Cold Spring Harbor symposia on quantitative biology, 2004, Volume: 69

    Topics: Amidohydrolases; Amino Acid Sequence; Animals; Cell Differentiation; Chromatin; Cloning, Organism; Embryonic Development; Epigenesis, Genetic; Female; Germ Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Hydrolases; Methylation; Mice; Models, Genetic; Molecular Sequence Data; Neoplasms; Pregnancy; Protein Methyltransferases; Protein-Arginine Deiminases

2004
Towards the human cancer epigenome: a first draft of histone modifications.
    Cell cycle (Georgetown, Tex.), 2005, Volume: 4, Issue:10

    Topics: Acetylation; Animals; Chromatin; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms

2005
Chromatin modifier enzymes, the histone code and cancer.
    European journal of cancer (Oxford, England : 1990), 2005, Volume: 41, Issue:16

    Topics: Acetylation; Chromatin; DNA Damage; DNA Methylation; Histone Code; Histones; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational; RNA Interference

2005
New therapeutic targets in cancer: the epigenetic connection.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2006, Volume: 8, Issue:4

    Topics: Acetylation; Amino Acid Sequence; Antineoplastic Agents; Clinical Trials as Topic; Disease Progression; DNA Methylation; DNA, Neoplasm; Drug Design; Epigenesis, Genetic; Forecasting; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Methylation; Models, Molecular; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Protein Conformation; Protein Processing, Post-Translational

2006
[E-cadherin cell adhesion system in human cancer].
    Seikagaku. The Journal of Japanese Biochemical Society, 2006, Volume: 78, Issue:7

    Topics: Actinin; Cadherins; Catenins; Cell Adhesion; Cell Adhesion Molecules; Delta Catenin; Gene Expression Regulation, Neoplastic; Humans; Methylation; Microfilament Proteins; Mutation; Neoplasm Invasiveness; Neoplasms; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Signal Transduction

2006
DNA methylation and histone modifications in patients with cancer: potential prognostic and therapeutic targets.
    Methods in molecular biology (Clifton, N.J.), 2007, Volume: 361

    Topics: Acetylation; Antineoplastic Agents; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Neoplasms; Prognosis; Protein Processing, Post-Translational; Tumor Suppressor Proteins

2007
The 3D structure of protein phosphatase 2A: new insights into a ubiquitous regulator of cell signaling.
    ACS chemical biology, 2007, Feb-20, Volume: 2, Issue:2

    Topics: Amino Acid Substitution; Crystallography, X-Ray; Holoenzymes; Humans; Methylation; Neoplasms; Noxae; Phosphoprotein Phosphatases; Protein Conformation; Protein Phosphatase 2; Protein Subunits; Signal Transduction

2007
The role of RASSF1A methylation in cancer.
    Disease markers, 2007, Volume: 23, Issue:1-2

    Topics: Animals; Biomarkers, Tumor; Humans; Methylation; Neoplasms; Tumor Suppressor Proteins

2007
Histone acetylation and methylation: combinatorial players for transcriptional regulation.
    Sub-cellular biochemistry, 2007, Volume: 41

    Topics: Acetylation; Amino Acid Sequence; Animals; Chromatin; Chromatin Assembly and Disassembly; Histone Acetyltransferases; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Molecular Sequence Data; Neoplasms; Protein Processing, Post-Translational; Transcription, Genetic

2007
Small molecule modulators in epigenetics: implications in gene expression and therapeutics.
    Sub-cellular biochemistry, 2007, Volume: 41

    Topics: Acetylation; Animals; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Carriers; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Neoplasms; Phosphorylation; Protamine Kinase; Protein Processing, Post-Translational; Rubinstein-Taybi Syndrome

2007
The function and regulation of the JARID1 family of histone H3 lysine 4 demethylases: the Myc connection.
    Cell cycle (Georgetown, Tex.), 2007, Jun-01, Volume: 6, Issue:11

    Topics: Animals; Caenorhabditis elegans Proteins; Cell Transformation, Neoplastic; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Epigenesis, Genetic; Gene Expression Regulation; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Jumonji Domain-Containing Histone Demethylases; Lysine; Mammals; Methylation; Mice; Mice, Knockout; Neoplasms; Nuclear Proteins; Nucleosomes; Oxidoreductases, N-Demethylating; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proto-Oncogene Proteins c-myc; Repressor Proteins; Retinoblastoma-Binding Protein 2; Saccharomyces cerevisiae Proteins; Substrate Specificity; Tumor Suppressor Proteins

2007
Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?
    Seminars in cancer biology, 2007, Volume: 17, Issue:5

    Topics: Animals; Anticarcinogenic Agents; Cell Transformation, Neoplastic; Chemoprevention; Flavones; Flavonoids; Humans; Methylation; Neoplasms

2007
Interplay between chromatin remodelers and protein arginine methyltransferases.
    Journal of cellular physiology, 2007, Volume: 213, Issue:2

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Arginine; Chromatin; Chromosomal Proteins, Non-Histone; DNA Repair; Gene Expression Regulation; Histones; Humans; Isoenzymes; Methylation; Neoplasms; Protein-Arginine N-Methyltransferases; Transcription Factors; Transcription, Genetic

2007
A role for epigenetics in hearing: Establishment and maintenance of auditory specific gene expression patterns.
    Hearing research, 2007, Volume: 233, Issue:1-2

    Topics: Acetylation; Animals; DNA Methylation; Embryonic Development; Epigenesis, Genetic; Gene Expression; Hearing; Hearing Loss; Histones; Humans; Methylation; Neoplasms

2007
Histone lysine demethylases: emerging roles in development, physiology and disease.
    Nature reviews. Genetics, 2007, Volume: 8, Issue:11

    Topics: Amino Acid Sequence; Animals; Gene Expression Regulation, Developmental; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Neoplasms; Nervous System Diseases

2007
[Research progress on the relationship between nutrition and cancer epigenetics---histone modification mechanisms].
    Ai zheng = Aizheng = Chinese journal of cancer, 2007, Volume: 26, Issue:9

    Topics: Acetylation; Biotinylation; DNA, Neoplasm; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Neoplasms; Nutritional Physiological Phenomena; Phosphorylation; Poly Adenosine Diphosphate Ribose

2007
Alternative lengthening of telomeres (ALT) and chromatin: is there a connection?
    Biochimie, 2008, Volume: 90, Issue:1

    Topics: Animals; Chromatin; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms; Recombination, Genetic; Sister Chromatid Exchange; Telomerase; Telomere

2008
RNA base damage and repair.
    Current pharmaceutical biotechnology, 2007, Volume: 8, Issue:6

    Topics: AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase; Animals; Dioxygenases; DNA Damage; DNA Repair; DNA Repair Enzymes; Escherichia coli Proteins; Humans; Methylation; Mixed Function Oxygenases; Neoplasms; Neurodegenerative Diseases; RNA; RNA Stability

2007
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.
    Genes & development, 2008, May-01, Volume: 22, Issue:9

    Topics: Aging; Animals; Cell Differentiation; Histones; Humans; Methylation; Models, Biological; Neoplasms; Oxidoreductases, N-Demethylating; Phylogeny

2008
Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis. A review and synthesis.
    Biochimica et biophysica acta, 1984, Volume: 738, Issue:1-2

    Topics: Adenosine; Animals; Azacitidine; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Choline; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA, Viral; Ethionine; Gene Expression Regulation; Homocysteine; Humans; Methionine; Methylation; Methyltransferases; Neoplasms; Oncogenes; Oncogenic Viruses; S-Adenosylhomocysteine; S-Adenosylmethionine; Simian virus 40

1984
Possible epigenetic mechanisms of tumor progression: induction of high-frequency heritable but phenotypically unstable changes in the tumorigenic and metastatic properties of tumor cell populations by 5-azacytidine treatment.
    Journal of cellular physiology. Supplement, 1984, Volume: 3

    Topics: Animals; Azacitidine; DNA; Ethyl Methanesulfonate; Humans; Mammary Neoplasms, Experimental; Methylation; Methylnitronitrosoguanidine; Models, Genetic; Mutation; Neoplasm Metastasis; Neoplasms; Neoplastic Stem Cells; Phenotype; Stem Cells

1984
5-Methylcytosine depletion during tumour development: an extension of the miscoding concept.
    British journal of cancer, 1983, Volume: 48, Issue:4

    Topics: 5-Methylcytosine; Alkylation; Amino Acid Metabolism, Inborn Errors; Animals; Carcinogens; Cell Transformation, Neoplastic; Choline Deficiency; Cytosine; DNA; DNA Repair; Gene Expression Regulation; Humans; Methylation; Methyltransferases; Models, Genetic; Neoplasms; Oncogenes; Rats; Tyrosine; Vitamin B 6 Deficiency

1983
Generation of phenotypic diversity and progression in metastatic tumor cells.
    Cancer metastasis reviews, 1984, Volume: 3, Issue:1

    Topics: Animals; Cell Transformation, Neoplastic; Chromosome Aberrations; Clone Cells; DNA; Humans; Methylation; Mutation; Neoplasm Metastasis; Neoplasms; Phenotype

1984
On a possible epigenetic mechanism(s) of tumor cell heterogeneity. The role of DNA methylation.
    Cancer metastasis reviews, 1983, Volume: 2, Issue:4

    Topics: Animals; Base Sequence; DNA; DNA, Neoplasm; Genes; Genetic Variation; Humans; Methylation; Models, Biological; Mutagens; Mutation; Neoplasms; Phenotype

1983
DNA methylation patterns. Formation and function.
    Biochimica et biophysica acta, 1984, Sep-10, Volume: 782, Issue:4

    Topics: Adenine Phosphoribosyltransferase; Animals; Cell Differentiation; DNA; DNA (Cytosine-5-)-Methyltransferases; Eukaryotic Cells; Genes; Growth Hormone; Humans; Insulin; Methylation; Methyltransferases; Neoplasms; Ovalbumin; Species Specificity; Vitellogenins

1984
Structure-activity relationships in the carcinogenicity of anticancer agents.
    Drug metabolism reviews, 1984, Volume: 15, Issue:3

    Topics: Alkylating Agents; Antimetabolites; Antineoplastic Agents; Aziridines; DNA; Hormones; Humans; Methylation; Mitosis; Neoplasms; Nitrogen Mustard Compounds; Structure-Activity Relationship

1984
[Methylation of nucleic acids and its relation to carcinogenesis (author's transl)].
    Wiener klinische Wochenschrift, 1980, Feb-15, Volume: 92, Issue:4

    Topics: Biochemical Phenomena; Biochemistry; Humans; Methylation; Neoplasms; Nucleic Acids; RNA, Ribosomal; tRNA Methyltransferases

1980
Parental genomic imprinting.
    Current opinion in pediatrics, 1995, Volume: 7, Issue:4

    Topics: Angelman Syndrome; Animals; Beckwith-Wiedemann Syndrome; Diabetes Mellitus, Type 1; Genomic Imprinting; Humans; Insulin-Like Growth Factor II; Kidney Neoplasms; Methylation; Mice; Muscle Proteins; Neoplasms; Prader-Willi Syndrome; RNA, Long Noncoding; RNA, Untranslated; Transcription, Genetic; Wilms Tumor

1995
Lipotrope deficiency and persistent changes in DNA methylation. Lipotrope deficiency and DNA methylation.
    Advances in experimental medicine and biology, 1995, Volume: 375

    Topics: Animals; Choline Deficiency; DNA; Folic Acid Deficiency; Humans; Lipid Metabolism; Liver; Methionine; Methylation; Neoplasms; Vitamin B 12 Deficiency

1995
DNA methylation and mutation.
    Mutation research, 1993, Volume: 285, Issue:1

    Topics: 5-Methylcytosine; Animals; Base Composition; Cytosine; Dinucleoside Phosphates; DNA; DNA Repair; Humans; Methylation; Mutation; Neoplasms

1993
[Activation of imprinted genes in human carcinogenesis].
    Nihon rinsho. Japanese journal of clinical medicine, 1995, Volume: 53, Issue:4

    Topics: Animals; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Genomic Imprinting; Humans; Insulin-Like Growth Factor II; Methylation; Neoplasms; Oncogenes

1995
The insertion of foreign DNA into mammalian genomes and its consequences: a concept in oncogenesis.
    Advances in cancer research, 1995, Volume: 66

    Topics: Adenoviridae; Animals; DNA; DNA, Viral; Gene Expression Regulation; Genetic Therapy; Humans; Methylation; Neoplasms; Promoter Regions, Genetic; Recombination, Genetic; Virus Integration

1995
DNA damage tolerance, mismatch repair and genome instability.
    BioEssays : news and reviews in molecular, cellular and developmental biology, 1994, Volume: 16, Issue:11

    Topics: Animals; Bacterial Proteins; Base Sequence; CHO Cells; Colonic Neoplasms; Cricetinae; DNA Damage; DNA Repair; DNA, Satellite; Escherichia coli; Female; Fungal Proteins; Genome; Guanine; Humans; Male; Mammals; Methylation; Methyltransferases; Molecular Sequence Data; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Saccharomyces cerevisiae; Sister Chromatid Exchange

1994
DNA methylation and cancer.
    Human molecular genetics, 1994, Volume: 3 Spec No

    Topics: Animals; Cell Transformation, Neoplastic; DNA Modification Methylases; DNA, Neoplasm; Gene Expression; Humans; Methylation; Mutation; Neoplasms

1994
Methyl donors in the diet and responses to chemical carcinogens.
    The American journal of clinical nutrition, 1995, Volume: 61, Issue:3 Suppl

    Topics: Animals; Carcinogens; Choline Deficiency; Diet; Folic Acid Deficiency; Humans; Liver Neoplasms, Experimental; Methionine; Methylation; Neoplasms

1995
Hypomethylation of DNA: an epigenetic mechanism involved in tumor promotion.
    Molecular carcinogenesis, 1994, Volume: 11, Issue:4

    Topics: Animals; DNA; DNA, Neoplasm; Gene Expression; Methylation; Mice; Neoplasms; Neoplasms, Experimental; Oncogenes

1994
Genomic imprinting, DNA methylation, and cancer.
    Journal of the National Cancer Institute, 1994, May-18, Volume: 86, Issue:10

    Topics: Animals; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms

1994
Mechanisms of carcinogenicity of methyl halides.
    Critical reviews in toxicology, 1993, Volume: 23, Issue:3

    Topics: Animals; DNA; Humans; Hydrocarbons, Brominated; Hydrocarbons, Iodinated; Methyl Chloride; Methylation; Mutagenicity Tests; Neoplasms

1993
Gene imprinting during placental and embryonic development.
    Molecular reproduction and development, 1993, Volume: 36, Issue:3

    Topics: Alleles; Animals; Biological Evolution; Dosage Compensation, Genetic; Embryonic and Fetal Development; Gene Expression Regulation; Humans; Methylation; Neoplasms; Placentation

1993
Epigenetic inheritance based on DNA methylation.
    EXS, 1993, Volume: 64

    Topics: Aging; Animals; Base Sequence; Cell Line; DNA; Fragile X Syndrome; Genetic Diseases, Inborn; Humans; Mammals; Methylation; Neoplasms; Repetitive Sequences, Nucleic Acid; Sex Chromosome Aberrations; X Chromosome; Zea mays

1993
DNA methylation and cancer.
    EXS, 1993, Volume: 64

    Topics: 5-Methylcytosine; Animals; Cytosine; Dinucleoside Phosphates; DNA; DNA Repair; Genes, p53; Genes, Tumor Suppressor; Humans; Methylation; Mutagens; Mutation; Neoplasms; Transcription, Genetic

1993
Cancer. Exploring the bowels of DNA methylation.
    Current biology : CB, 1995, Sep-01, Volume: 5, Issue:9

    Topics: Animals; DNA; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Humans; Methylation; Mice; Neoplasms; Proto-Oncogenes

1995
Genomic imprinting, DNA methylation, and cancer.
    Journal of the National Cancer Institute. Monographs, 1995, Issue:17

    Topics: Animals; Beckwith-Wiedemann Syndrome; DNA, Neoplasm; Genomic Imprinting; Humans; Methylation; Models, Genetic; Neoplasms; Neoplasms, Experimental; Pedigree

1995
[Folate deficiency, cancer and congenital abnormalities. Is there a connection?].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1996, Jan-20, Volume: 116, Issue:2

    Topics: Adult; Congenital Abnormalities; DNA; Female; Folic Acid; Folic Acid Deficiency; Hematinics; Humans; Methylation; Neoplasms; Pregnancy

1996
A possible role in chemical carcinogenesis for epigenetic, heritable changes in gene expression.
    Molecular carcinogenesis, 1996, Volume: 15, Issue:4

    Topics: Animals; Carcinogens; Chromatin; DNA-Binding Proteins; Gene Expression; Genes, Regulator; Helix-Loop-Helix Motifs; Methylation; Models, Biological; Neoplasms; Repressor Proteins; Transcription Factors

1996
DNA methylation and polyamines in embryonic development and cancer.
    The International journal of developmental biology, 1995, Volume: 39, Issue:5

    Topics: 5-Methylcytosine; Animals; Cell Transformation, Neoplastic; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Replication; Embryonic and Fetal Development; Female; Gene Expression Regulation, Developmental; Humans; Male; Methylation; Mice; Mutagenesis; Neoplasms; Nucleic Acid Conformation; Oogenesis; Polyamines; Replication Origin; Spermatogenesis; Transcription, Genetic

1995
DNA methylation errors and cancer.
    Cancer research, 1996, Jun-01, Volume: 56, Issue:11

    Topics: 5-Methylcytosine; Animals; Cytosine; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Imprinting, Psychological; Methylation; Mutation; Neoplasms

1996
DNA-replication fidelity, mismatch repair and genome instability in cancer cells.
    European journal of biochemistry, 1996, Jun-01, Volume: 238, Issue:2

    Topics: Base Sequence; Colorectal Neoplasms, Hereditary Nonpolyposis; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Escherichia coli; Genetic Predisposition to Disease; Humans; Methylation; Microsatellite Repeats; Molecular Sequence Data; Mutation; Neoplasms

1996
[Molecular cancer epidemiology--the present status and future possibilities].
    Nihon eiseigaku zasshi. Japanese journal of hygiene, 1996, Volume: 50, Issue:6

    Topics: Animals; Base Sequence; Flavonoids; Genes, p53; Genes, Retinoblastoma; Genes, Tumor Suppressor; Humans; Methylation; Molecular Epidemiology; Molecular Sequence Data; Mutation; Neoplasms; Promoter Regions, Genetic; Prostaglandin D2

1996
Alcohol and cancer.
    Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1994, Volume: 2

    Topics: Animals; Carcinogens; Epidemiologic Factors; Esophageal Neoplasms; Ethanol; Folic Acid; Humans; Methylation; Mice; Murine Acquired Immunodeficiency Syndrome; Neoplasms; Vitamin E

1994
Methioninase: a therapeutic for diseases related to altered methionine metabolism and transmethylation: cancer, heart disease, obesity, aging, and Parkinson's disease.
    Human cell, 1997, Volume: 10, Issue:1

    Topics: Aging; Animals; Carbon-Sulfur Lyases; Drug Interactions; Drug Therapy, Combination; Heart Diseases; Humans; Methionine; Methylation; Neoplasms; Obesity; Parkinson Disease; Recombinant Proteins

1997
Lessons from basic research in selenium and cancer prevention.
    The Journal of nutrition, 1998, Volume: 128, Issue:11

    Topics: Anticarcinogenic Agents; Dietary Supplements; Garlic; Humans; Methylation; Neoplasms; Plants, Medicinal; Selenium; Sodium Selenite

1998
Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase.
    Carcinogenesis, 1999, Volume: 20, Issue:9

    Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cell Cycle Proteins; Cell Division; Cysteine; Enzyme Inhibitors; Gene Expression Regulation; Humans; Methylation; Mice; Molecular Weight; Neoplasms; Neoplasms, Experimental; Oxidation-Reduction; Protein Kinase C; Proteins; Selenium; Selenocysteine; Selenoproteins; Thioredoxin-Disulfide Reductase; Thioredoxins; Transcription Factors

1999
[Genome methylation and its role in functioning of the eukaryotic organism].
    Genetika, 2000, Volume: 36, Issue:11

    Topics: Animals; Chromatin; CpG Islands; DNA; DNA Modification Methylases; DNA Replication; DNA-Binding Proteins; Eukaryotic Cells; Genome; Genomic Imprinting; Humans; Methylation; Neoplasms; Protein Structure, Tertiary; Recombination, Genetic; Transcription, Genetic

2000
Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications.
    Annals of internal medicine, 2001, Apr-03, Volume: 134, Issue:7

    Topics: 5-Methylcytosine; Acetylation; Antineoplastic Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; CpG Islands; Cytosine; DNA Methylation; Fetal Hemoglobin; Gene Expression Regulation, Neoplastic; Hematologic Diseases; Histones; Humans; Methylation; Neoplasms

2001
Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites.
    Toxicology and applied pharmacology, 2001, May-01, Volume: 172, Issue:3

    Topics: Animals; Arsenic; Cell Division; Disease Models, Animal; DNA Methylation; DNA Repair; Genes, p53; Growth Substances; Humans; Methylation; Mice; Mice, Transgenic; Neoplasms; Rats

2001
Histone methylation versus histone acetylation: new insights into epigenetic regulation.
    Current opinion in cell biology, 2001, Volume: 13, Issue:3

    Topics: Acetylation; Animals; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA Methylation; Gene Expression Regulation, Developmental; Gene Silencing; Heterochromatin; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms; Protein Methyltransferases; Transcription, Genetic

2001
Catechol-O-Methyltransferase (COMT)-mediated methylation metabolism of endogenous bioactive catechols and modulation by endobiotics and xenobiotics: importance in pathophysiology and pathogenesis.
    Current drug metabolism, 2002, Volume: 3, Issue:3

    Topics: Animals; Catechol O-Methyltransferase; Catecholamines; Catechols; Dopamine; Enzyme Inhibitors; Estrogens; Humans; Kinetics; Methylation; Neoplasms; Parkinson Disease; Plant Preparations; Polymorphism, Genetic; Xenobiotics

2002
The methylation of tRNA.
    Biochimie, 1976, Volume: 58, Issue:6

    Topics: Animals; Base Sequence; Binding Sites; Cations, Monovalent; Cell Differentiation; Embryo, Mammalian; Escherichia coli; Gonadal Steroid Hormones; Humans; Methylation; Neoplasms; Nucleic Acid Conformation; Nucleosides; Polyamines; RNA, Transfer; S-Adenosylmethionine; Species Specificity; Structure-Activity Relationship; tRNA Methyltransferases

1976
Catechol-O-methyl transferase: pharmacological aspects and physiological role.
    Pharmacological reviews, 1975, Volume: 27, Issue:2

    Topics: Aging; Animals; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catecholamines; Catechols; Chickens; Female; Humans; Hypertension; Invertebrates; Isoenzymes; Isomerism; Kinetics; Mental Disorders; Methylation; Molecular Weight; Neoplasms; Plants; Pyrogallol; Rats; Subcellular Fractions; Tropolone; Uterus; Vertebrates

1975
[Parental imprinting of mammalian genomes].
    Seikagaku. The Journal of Japanese Biochemical Society, 1992, Volume: 64, Issue:10

    Topics: Alleles; Animals; Cell Differentiation; Chromatin; Chromosomes; DNA; Genetic Diseases, Inborn; Genome; Humans; Methylation; Mice; Mice, Inbred BALB C; Neoplasms

1992
Abnormal regional hypermethylation in cancer cells.
    AIDS research and human retroviruses, 1992, Volume: 8, Issue:5

    Topics: Adult; DNA; Humans; Methylation; Neoplasms

1992
Methylation, mutation and cancer.
    BioEssays : news and reviews in molecular, cellular and developmental biology, 1992, Volume: 14, Issue:1

    Topics: 5-Methylcytosine; Animals; Cell Transformation, Neoplastic; Cytosine; Deamination; DNA; DNA, Neoplasm; Female; Genes, p53; Genetic Diseases, Inborn; Humans; Male; Methylation; Mutation; Neoplasms; Neoplasms, Experimental; Vertebrates

1992
Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression.
    Cancer cells (Cold Spring Harbor, N.Y. : 1989), 1991, Volume: 3, Issue:10

    Topics: Chromatin; DNA; Humans; Methylation; Neoplasms

1991
Genomic imprinting.
    Current opinion in genetics & development, 1991, Volume: 1, Issue:1

    Topics: Animals; Chromosome Aberrations; Chromosome Deletion; Chromosome Disorders; Dosage Compensation, Genetic; Gene Expression Regulation; Humans; Mammals; Methylation; Models, Genetic; Neoplasms; Parents; Phenotype; Ploidies; Syndrome

1991
Current status of protein methylation in carcinogenesis.
    Critical reviews in oncogenesis, 1991, Volume: 2, Issue:2

    Topics: Animals; Cell Transformation, Neoplastic; Esterification; Histones; Humans; Methylation; Methyltransferases; Neoplasms; Nuclear Proteins; Proteins

1991
Unbalanced transmethylation and the perturbation of the differentiated state leading to cancer.
    BioEssays : news and reviews in molecular, cellular and developmental biology, 1990, Volume: 12, Issue:4

    Topics: Animals; DNA, Neoplasm; Genotype; Humans; Methionine; Methylation; Neoplasms

1990
Exposure of humans to endogenous N-nitroso compounds: implications in cancer etiology.
    Mutation research, 1990, Volume: 238, Issue:3

    Topics: Adenine; Bacterial Infections; Esophageal Neoplasms; Gastric Mucosa; Humans; Kinetics; Methylation; Neoplasms; Nicotiana; Nitrosamines; Nitrosation; Nitroso Compounds; Parasitic Diseases; Plants, Toxic; Stomach Neoplasms

1990
The role of DNA methylation in cancer.
    Advances in cancer research, 1990, Volume: 54

    Topics: Animals; Carcinogens; DNA; Humans; Male; Methylation; Neoplasms; Signal Transduction; Spermatogenesis

1990
DNA methylation and cancer.
    Cancer research, 1986, Volume: 46, Issue:2

    Topics: Animals; Azacitidine; Cell Division; DNA (Cytosine-5-)-Methyltransferases; DNA Replication; DNA, Neoplasm; Eukaryotic Cells; Gene Expression Regulation; Humans; Methylation; Neoplasms

1986
Labile methyl groups and the promotion of cancer.
    Annual review of nutrition, 1986, Volume: 6

    Topics: Animals; Antibody Formation; Carcinogens; Choline; Choline Deficiency; Diet; DNA; Folic Acid; Folic Acid Deficiency; Humans; Immunity, Cellular; Lipotropic Agents; Liver; Liver Neoplasms; Methionine; Methylation; Neoplasms; Neoplasms, Experimental; Pharmaceutical Preparations; Risk; Tetrahydrofolates; Vitamin B 12; Vitamin B 12 Deficiency

1986
Hypomethylation of DNA in the regulation of gene expression.
    Developmental biology (New York, N.Y. : 1985), 1988, Volume: 5

    Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Differentiation; Cytosine; DNA; Gene Expression Regulation; Humans; Methylation; Methyltransferases; Neoplasms

1988
Unequal parental contributions: genomic imprinting in mammals.
    The New biologist, 1989, Volume: 1, Issue:2

    Topics: Animals; Disease Susceptibility; DNA; Dosage Compensation, Genetic; Embryonic and Fetal Development; Female; Gene Expression Regulation; Genetic Diseases, Inborn; Humans; Male; Methylation; Mice; Mice, Inbred Strains; Mice, Transgenic; Neoplasms; Nuclear Transfer Techniques; Sex Determination Analysis; X Chromosome; Zygote

1989
Genetic and molecular aspects of human multigenerational carcinogenesis.
    IARC scientific publications, 1989, Issue:96

    Topics: Animals; Eye Neoplasms; Humans; Kidney Neoplasms; Methylation; Mutation; Neoplasms; Retinoblastoma; Wilms Tumor

1989
Altering gene expression with 5-azacytidine.
    Cell, 1985, Volume: 40, Issue:3

    Topics: Anemia, Sickle Cell; Animals; Azacitidine; Cell Differentiation; Cell Line; DNA; Embryo, Mammalian; Embryo, Nonmammalian; Fetal Hemoglobin; Gene Expression Regulation; Genes; Genes, Regulator; Methylation; Mutation; Neoplasms; Thalassemia; Thymidine Kinase

1985
[Clonal evolution in tumor cell population].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:10

    Topics: Animals; Biological Evolution; DNA Repair; DNA Replication; DNA, Neoplasm; Drug Resistance; Genetic Markers; Genetic Variation; Humans; Methylation; Mice; Neomycin; Neoplasms; Nondisjunction, Genetic; Sarcoma, Experimental; Selection, Genetic; Tumor Cells, Cultured

1989
Tumor autocrine motility factor.
    Progress in clinical and biological research, 1986, Volume: 212

    Topics: Cell Line; Cell Movement; Glucose-6-Phosphate Isomerase; Humans; Melanoma; Membrane Proteins; Methylation; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Oncogenes

1986
Genetic instability and tumor progression.
    Pathology and immunopathology research, 1986, Volume: 5, Issue:6

    Topics: Aneuploidy; Animals; Chromosome Aberrations; Clone Cells; DNA, Neoplasm; Gene Expression Regulation; Humans; Methylation; Models, Biological; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Neoplasms, Experimental; Oncogenes; Precancerous Conditions

1986
DNA methylation and epigenetic defects in carcinogenesis.
    Mutation research, 1987, Volume: 181, Issue:2

    Topics: Animals; DNA; Gene Expression Regulation; Humans; Methylation; Neoplasms

1987
A unified theory for the development of cancer.
    Bioscience reports, 1986, Volume: 6, Issue:8

    Topics: Animals; Cell Differentiation; Cell Transformation, Neoplastic; Gene Amplification; Gene Expression Regulation; Genes, Recessive; Humans; Methylation; Mutation; Neoplasms; Oncogenes; Retroviridae; Transduction, Genetic; Translocation, Genetic

1986
Protein modification, metabolic controls, and their significance in transformation in eukaryotic cells.
    Journal of the National Cancer Institute, 1974, Volume: 53, Issue:5

    Topics: Acetylation; Adenosine Triphosphate; Animals; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Chromosomes; Contact Inhibition; Cyclic AMP; DNA Replication; Glycoproteins; Inclusion Bodies; Methylation; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Neoplasms; Nucleoproteins; Oxidative Phosphorylation; Transcription, Genetic

1974
Role of the methylated nucleic acids in carcinogenesis.
    Experimental and molecular pathology, 1969, Volume: 10, Issue:2

    Topics: Animals; DNA, Neoplasm; Humans; Leukemia; Leukemia, Experimental; Methylation; Mice; Neoplasms; Neoplasms, Experimental; Nucleic Acids; RNA, Neoplasm; Species Specificity; Transferases

1969
The possible role of nucleic acid methylases in the induction of cancer.
    Cancer research, 1971, Volume: 31, Issue:5

    Topics: Alkylating Agents; Alkylation; Carcinogens; Cell Transformation, Neoplastic; DNA; Ethionine; Methylation; Methyltransferases; Neoplasms; Nucleic Acids; RNA, Neoplasm; RNA, Transfer; Transferases

1971
Summary of symposium on transfer RNA and transfer RNA modification in differentiation and neoplasia.
    Cancer research, 1971, Volume: 31, Issue:5

    Topics: Amino Acids; Base Sequence; Carcinogens; Cell Differentiation; Genes, Regulator; Genetic Code; Genetics, Medical; Genetics, Microbial; Methylation; Methyltransferases; Molecular Biology; Mutation; Neoplasms; RNA, Transfer; Suppression, Genetic; Transferases

1971

Trials

2 trial(s) available for isomethyleugenol and Neoplasms

ArticleYear
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide

2023
Population pharmacokinetics of HM781-36 (poziotinib), pan-human EGF receptor (HER) inhibitor, and its two metabolites in patients with advanced solid malignancies.
    Cancer chemotherapy and pharmacology, 2015, Volume: 75, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biotransformation; Dose-Response Relationship, Drug; Drugs, Investigational; ErbB Receptors; Female; Food-Drug Interactions; Half-Life; Humans; Hydroxylation; Intestinal Absorption; Male; Metabolic Clearance Rate; Methylation; Middle Aged; Models, Biological; Neoplasms; Quinazolines; Tablets

2015

Other Studies

345 other study(ies) available for isomethyleugenol and Neoplasms

ArticleYear
METTL3-mediated m
    Nature communications, 2021, 09-17, Volume: 12, Issue:1

    Topics: Adenosine; Animals; Carcinogenesis; Cell Line, Tumor; Gene Deletion; Homeostasis; Interleukin-15; Killer Cells, Natural; Lymphocytes, Tumor-Infiltrating; Methylation; Methyltransferases; Mice, Inbred C57BL; Mice, Knockout; Neoplasms; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Proto-Oncogene Proteins c-akt; RNA; Signal Transduction; Tumor Microenvironment

2021
Aberrant RNA methylation triggers recruitment of an alkylation repair complex.
    Molecular cell, 2021, 10-21, Volume: 81, Issue:20

    Topics: AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase; Cell Nucleus; DNA Helicases; DNA Methylation; DNA-Binding Proteins; HEK293 Cells; HeLa Cells; Humans; Methylation; Neoplasms; Nuclear Proteins; R-Loop Structures; RNA Processing, Post-Transcriptional; RNA, Neoplasm; Spliceosomes; Transcription, Genetic; Ubiquitination

2021
Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022.
    Nucleic acids research, 2022, 01-07, Volume: 50, Issue:D1

    Topics: Animals; China; Computational Biology; Databases, Factual; Databases, Genetic; Databases, Pharmaceutical; Dogs; Epigenome; Genome, Human; Genome, Viral; Genomics; Humans; Methylation; Neoplasms; Regeneration; SARS-CoV-2; Single-Cell Analysis; Software; Synthetic Biology

2022
Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2.
    Nature communications, 2021, 11-15, Volume: 12, Issue:1

    Topics: Carcinogenesis; Cryoelectron Microscopy; DNA Methylation; Epigenomics; Histone-Lysine N-Methyltransferase; Histones; Humans; Kinetics; Methylation; Molecular Dynamics Simulation; Neoplasms; Oncogenes; Repressor Proteins

2021
Methionine synthase supports tumour tetrahydrofolate pools.
    Nature metabolism, 2021, Volume: 3, Issue:11

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Line, Tumor; Cell Proliferation; Folic Acid; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Metabolic Networks and Pathways; Methionine; Methylation; Mutation; Neoplasms; Purines; Tetrahydrofolates; Vitamin B 12 Deficiency

2021
Identification of Pax protein inhibitors that suppress target gene expression and cancer cell proliferation.
    Cell chemical biology, 2022, 03-17, Volume: 29, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Gene Expression; Kidney; Methylation; Mice; Neoplasms; PAX2 Transcription Factor

2022
Regulation of PP2A, PP4, and PP6 holoenzyme assembly by carboxyl-terminal methylation.
    Scientific reports, 2021, 11-29, Volume: 11, Issue:1

    Topics: Animals; Cell Line, Tumor; Gene Expression Regulation, Enzymologic; HEK293 Cells; HeLa Cells; Humans; Mass Spectrometry; MCF-7 Cells; Methylation; Mice; Neoplasms; Neurodegenerative Diseases; Phosphoprotein Phosphatases; Phosphorylation; Protein Domains; Protein Interaction Mapping; Protein Phosphatase 2; Protein Processing, Post-Translational; Proteomics

2021
Models based on nucleic acid methylation regulators will contribute to facilitating cancer precision medicine.
    BMC medicine, 2021, 12-01, Volume: 19, Issue:1

    Topics: Humans; Methylation; Neoplasms; Precision Medicine; RNA, Neoplasm

2021
Application of droplet digital polymerase chain reaction of plasma methylated septin 9 on detection and early monitoring of colorectal cancer.
    Scientific reports, 2021, 12-06, Volume: 11, Issue:1

    Topics: Area Under Curve; Biomarkers, Tumor; Cell Line, Tumor; Colorectal Neoplasms; DNA Methylation; Early Detection of Cancer; Epigenesis, Genetic; Female; Humans; Male; Methylation; Neoplasms; Polymerase Chain Reaction; Postoperative Period; ROC Curve; Septins

2021
Tracking the Dynamic Histone Methylation of H3K27 in Live Cancer Cells.
    ACS sensors, 2021, 12-24, Volume: 6, Issue:12

    Topics: Epigenesis, Genetic; Fluorescence Resonance Energy Transfer; Genome; Histones; Methylation; Neoplasms

2021
Analysis of the expression patterns and clinical relevance of m
    Future oncology (London, England), 2022, Volume: 18, Issue:5

    Topics: Biomarkers, Tumor; Computational Biology; Disease Progression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Methylation; Neoplasms; Prognosis; Sequence Analysis, RNA; Tumor Microenvironment

2022
Palmitic acid: Enabling the tumor's nerves.
    Cell metabolism, 2022, 01-04, Volume: 34, Issue:1

    Topics: Epigenomics; Humans; Methylation; Neoplasms; Palmitic Acid; Tumor Microenvironment

2022
Joint effects of genomic markers and urinary methylation capacity associated with inorganic arsenic metabolism on the occurrence of cancers among residents in arseniasis-endemic areas: A cohort subset with average fifteen-year follow-up.
    Biomedical journal, 2021, Volume: 44, Issue:6 Suppl 2

    Topics: Arsenic; Arsenicals; Follow-Up Studies; Genomics; Glutathione Transferase; Humans; Methylation; Methyltransferases; Neoplasms

2021
Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
    Journal of medicinal chemistry, 2022, 04-14, Volume: 65, Issue:7

    Topics: Animals; Enzyme Inhibitors; Histones; Humans; Methylation; Mice; Neoplasms; Polycomb Repressive Complex 2

2022
A Comprehensive Analysis of METTL1 to Immunity and Stemness in Pan-Cancer.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Humans; Immunotherapy; Methylation; Methyltransferases; Neoplasms; Prognosis; Tumor Microenvironment

2022
Global analysis of protein arginine methylation.
    Cell reports methods, 2021, 06-21, Volume: 1, Issue:2

    Topics: Animals; Arginine; Methylation; Mice; Neoplasms; Protein Processing, Post-Translational; Proteins

2021
A Novel Signature Based on m6A RNA Methylation Regulators Reveals Distinct Prognostic Subgroups and Associates with Tumor Immunity of Patients with Pancreatic Neuroendocrine Neoplasms.
    Neuroendocrinology, 2022, Volume: 112, Issue:12

    Topics: Adenosine; Humans; Methylation; Multivariate Analysis; Neoplasms; Prognosis; RNA

2022
Histone demethylase KDM4C is a functional dependency in JAK2-mutated neoplasms.
    Leukemia, 2022, Volume: 36, Issue:7

    Topics: Animals; Histone Demethylases; Humans; Janus Kinase 2; Jumonji Domain-Containing Histone Demethylases; Methylation; Mice; Neoplasms; Signal Transduction

2022
Arginine methylation of MTHFD1 by PRMT5 enhances anoikis resistance and cancer metastasis.
    Oncogene, 2022, Volume: 41, Issue:32

    Topics: Anoikis; Arginine; Formate-Tetrahydrofolate Ligase; Humans; Methylation; Methylenetetrahydrofolate Dehydrogenase (NADP); Minor Histocompatibility Antigens; Neoplasms; Protein-Arginine N-Methyltransferases

2022
Methionine deficiency facilitates antitumour immunity by altering m
    Gut, 2023, Volume: 72, Issue:3

    Topics: Animals; CD8-Positive T-Lymphocytes; Methionine; Methylation; Mice; Neoplasms; Programmed Cell Death 1 Receptor; Racemethionine

2023
PRMT5 activates AKT via methylation to promote tumor metastasis.
    Nature communications, 2022, 07-08, Volume: 13, Issue:1

    Topics: Arginine; Cell Line, Tumor; Humans; Methylation; Neoplasms; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins c-akt

2022
Detection of Hypomethylation in Long-ctDNA.
    Clinical chemistry, 2022, 09-01, Volume: 68, Issue:9

    Topics: Cell-Free Nucleic Acids; Circulating Tumor DNA; Humans; Methylation; Neoplasms

2022
Re: Sabrina H. Rossi, Grant D. Stewart. Re: Clinical Validation of a Targeted Methylation-based Multi-cancer Early Detection Test Using an Independent Validation Set. Eur Urol. 2022;82:442-443.
    European urology, 2022, Volume: 82, Issue:5

    Topics: Early Detection of Cancer; Humans; Methylation; Neoplasms

2022
Pan-cancer landscape of abnormal ctDNA methylation across human tumors.
    Cancer genetics, 2022, Volume: 268-269

    Topics: Biomarkers, Tumor; Circulating Tumor DNA; Humans; Methylation; Mutation; Neoplasms

2022
Mutation-Agnostic Detection of Colorectal Cancer Using Liquid Biopsy-Based Methylation-Specific Signatures.
    The oncologist, 2023, 04-06, Volume: 28, Issue:4

    Topics: Biomarkers, Tumor; Circulating Tumor DNA; Colorectal Neoplasms; Humans; Liquid Biopsy; Methylation; Mutation; Neoplasms

2023
Integrative Transcriptomic Analysis Identify Potential m6A Pathway-Related Drugs That Inhibit Cancer Cell Proliferation.
    Genes, 2022, 11-02, Volume: 13, Issue:11

    Topics: Adenosine; Cell Proliferation; Gene Expression Profiling; Humans; Methylation; Neoplasms; Transcriptome

2022
NTRK-rearranged spindle cell neoplasms are ubiquitous tumours of myofibroblastic lineage with a distinct methylation class.
    Histopathology, 2023, Volume: 82, Issue:4

    Topics: Adult; Child; Fibrosarcoma; Humans; Methylation; Neoplasms; Oncogene Proteins, Fusion; Receptor, trkA; RNA; Soft Tissue Neoplasms

2023
Performance of a targeted methylation-based multi-cancer early detection test by race and ethnicity.
    Preventive medicine, 2023, Volume: 167

    Topics: Early Detection of Cancer; Ethnicity; Humans; Methylation; Neoplasms; Prospective Studies; Socioeconomic Factors; United States

2023
Exploratory Metabolomics Underscores the Folate Enzyme ALDH1L1 as a Regulator of Glycine and Methylation Reactions.
    Molecules (Basel, Switzerland), 2022, Dec-01, Volume: 27, Issue:23

    Topics: Aldehyde Dehydrogenase 1 Family; Folic Acid; Glycine; Humans; Metabolomics; Methylation; Neoplasms; Retinal Dehydrogenase; S-Adenosylmethionine

2022
Design, synthesis and evaluation of antitumor activity of selective PRMT6 inhibitors.
    European journal of medicinal chemistry, 2023, Feb-05, Volume: 247

    Topics: Humans; Methylation; Neoplasms; Nuclear Proteins; Protein-Arginine N-Methyltransferases; Repressor Proteins

2023
Peptides Targeting RNA m
    ChemMedChem, 2023, 02-14, Volume: 18, Issue:4

    Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Humans; Male; Methylation; Methyltransferases; Neoplasms; RNA; RNA, Messenger

2023
Proof-of-Concept Method to Study Uncharacterized Methyltransferases Using PRDM15.
    International journal of molecular sciences, 2023, Jan-10, Volume: 24, Issue:2

    Topics: DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Methyltransferases; Neoplasms; Transcription Factors

2023
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma.
    Nature chemical biology, 2023, Volume: 19, Issue:9

    Topics: Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Lymphoma; Methylation; Neoplasms; Polycomb Repressive Complex 2

2023
Detection of rare mutations, copy number alterations, and methylation in the same template DNA molecules.
    Proceedings of the National Academy of Sciences of the United States of America, 2023, 04-11, Volume: 120, Issue:15

    Topics: 5-Methylcytosine; DNA; DNA Copy Number Variations; DNA Methylation; Female; Humans; Methylation; Mutation; Neoplasms

2023
The beneficial effect of cyclohexyl substituent on the
    Dalton transactions (Cambridge, England : 2003), 2023, May-02, Volume: 52, Issue:17

    Topics: Animals; Humans; Methylation; Mice; Neoplasms

2023
The T1150A cancer mutant of the protein lysine dimethyltransferase NSD2 can introduce H3K36 trimethylation.
    The Journal of biological chemistry, 2023, Volume: 299, Issue:6

    Topics: Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mutation; Neoplasms

2023
Comments on "Methylation scores for smoking, alcohol consumption and body mass index and risk of seven types of cancer".
    International journal of cancer, 2023, 10-15, Volume: 153, Issue:8

    Topics: Alcohol Drinking; Body Mass Index; Humans; Methylation; Neoplasms; Risk Factors; Smoking

2023
Reply to: Comments on "Methylation scores for smoking, alcohol consumption and body mass index and risk of seven types of cancer".
    International journal of cancer, 2023, 10-15, Volume: 153, Issue:8

    Topics: Alcohol Drinking; Body Mass Index; Humans; Methylation; Neoplasms; Risk Factors; Smoking

2023
PARP1 modulates METTL3 promoter chromatin accessibility and associated LPAR5 RNA m
    Molecular therapy : the journal of the American Society of Gene Therapy, 2023, 09-06, Volume: 31, Issue:9

    Topics: Animals; Chromatin; Humans; Methylation; Methyltransferases; Mice; Neoplasms; Poly (ADP-Ribose) Polymerase-1; Receptors, Lysophosphatidic Acid; RNA; RNA, Messenger; Transcription Factors

2023
Integrative Multi-Omics Analysis of Oncogenic EZH2 Mutants: From Epigenetic Reprogramming to Molecular Signatures.
    International journal of molecular sciences, 2023, Jul-12, Volume: 24, Issue:14

    Topics: Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Histones; Humans; Methylation; Multiomics; Neoplasms; Polycomb Repressive Complex 2

2023
Manipulating mitochondrial electron flow enhances tumor immunogenicity.
    Science (New York, N.Y.), 2023, 09-22, Volume: 381, Issue:6664

    Topics: Antigen Presentation; Antigens, Neoplasm; Cell Line, Tumor; Electron Transport Complex I; Electron Transport Complex II; Electrons; Gene Knockout Techniques; Histones; HSP40 Heat-Shock Proteins; Humans; Melanoma; Methylation; Mitochondria; Neoplasms

2023
Rare de novo gain-of-function missense variants in DOT1L are associated with developmental delay and congenital anomalies.
    American journal of human genetics, 2023, 11-02, Volume: 110, Issue:11

    Topics: Congenital Abnormalities; Developmental Disabilities; Drosophila; Drosophila Proteins; Gain of Function Mutation; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms

2023
Protein methylation characterization using NMR without isotopic labeling.
    Talanta, 2024, Feb-01, Volume: 268, Issue:Pt 1

    Topics: Animals; Histone-Lysine N-Methyltransferase; Histones; Methylation; Mice; Neoplasms

2024
Histone methyltransferase activity affects metabolism in human cells independently of transcriptional regulation.
    PLoS biology, 2023, Volume: 21, Issue:10

    Topics: Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Neoplasms; Protein Processing, Post-Translational; S-Adenosylmethionine

2023
Metabolic sinkholes: Histones as methyl repositories.
    PLoS biology, 2023, Volume: 21, Issue:10

    Topics: Gene Expression Regulation; Histone Methyltransferases; Histones; Humans; Methylation; Neoplasms

2023
FunDMDeep-m6A: identification and prioritization of functional differential m6A methylation genes.
    Bioinformatics (Oxford, England), 2019, 07-15, Volume: 35, Issue:14

    Topics: Animals; Humans; Methylation; Neoplasms; Protein Interaction Maps; RNA; RNA, Messenger; Software

2019
Molecular characterization and clinical relevance of m
    Molecular cancer, 2019, 09-14, Volume: 18, Issue:1

    Topics: Adenosine; Computational Biology; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genetic Variation; Humans; Methylation; Neoplasms; Prognosis; Signal Transduction

2019
The Transsulfuration Pathway Makes, the Tumor Takes.
    Cell metabolism, 2019, 11-05, Volume: 30, Issue:5

    Topics: Cysteine; Humans; Methionine; Methylation; Neoplasms

2019
One-carbon metabolism for cancer diagnostic and therapeutic approaches.
    Cancer letters, 2020, 02-01, Volume: 470

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Carbon; DNA; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Metabolic Networks and Pathways; Methylation; Neoplasms

2020
Bregmannian consensus clustering for cancer subtypes analysis.
    Computer methods and programs in biomedicine, 2020, Volume: 189

    Topics: Algorithms; Cluster Analysis; Gene Expression Profiling; Methylation; MicroRNAs; Neoplasms; RNA, Messenger

2020
Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A.
    Biochemistry, 2020, 02-11, Volume: 59, Issue:5

    Topics: Biocatalysis; Histones; Humans; Methylation; Neoplasms; Retinoblastoma-Binding Protein 2; Substrate Specificity

2020
Potential 2,4-dimethyl-1H-pyrrole-3-carboxamide bearing benzimidazole template: Design, synthesis, in vitro anticancer and in silico ADME study.
    Bioorganic chemistry, 2020, Volume: 97

    Topics: Antineoplastic Agents; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Humans; Methylation; Models, Molecular; Neoplasms; Pyrroles; Structure-Activity Relationship

2020
A novel EZH2 inhibitor induces synthetic lethality and apoptosis in PBRM1-deficient cancer cells.
    Cell cycle (Georgetown, Tex.), 2020, Volume: 19, Issue:7

    Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Indoles; Lysine; Methylation; Molecular Docking Simulation; Molecular Dynamics Simulation; Neoplasms; Prognosis; Pyridones; Reproducibility of Results; Synthetic Lethal Mutations; Transcription Factors

2020
Proteomic Analyses Identify a Novel Role for EZH2 in the Initiation of Cancer Cell Drug Tolerance.
    Journal of proteome research, 2020, 04-03, Volume: 19, Issue:4

    Topics: Drug Tolerance; Enhancer of Zeste Homolog 2 Protein; Histones; Methylation; Neoplasms; Polycomb Repressive Complex 2; Proteomics

2020
The pan-cancer landscape of netrin family reveals potential oncogenic biomarkers.
    Scientific reports, 2020, 03-23, Volume: 10, Issue:1

    Topics: Biomarkers, Tumor; Endometrial Neoplasms; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; GPI-Linked Proteins; Humans; Kaplan-Meier Estimate; Methylation; Mutation Rate; Neoplasms; Netrins; Quantitative Trait Loci

2020
Using methylation signatures on cell-free DNA for early cancer detection: a new era in liquid biopsy?
    Annals of oncology : official journal of the European Society for Medical Oncology, 2020, Volume: 31, Issue:6

    Topics: Biomarkers, Tumor; Cell-Free Nucleic Acids; DNA Methylation; Early Detection of Cancer; Humans; Liquid Biopsy; Methylation; Neoplasms

2020
On a New Proposed Mechanism of 5-Fluorouracil-Mediated Cytotoxicity.
    Trends in cancer, 2020, Volume: 6, Issue:5

    Topics: Cell Cycle; Cell Survival; DNA Damage; Fluorouracil; Humans; Methylation; Neoplasms; Recombinational DNA Repair; RNA, Transfer; tRNA Methyltransferases; Uridine Triphosphate

2020
[mRNA methylation regulates cross-presentation of tumor-derived antigens].
    Medecine sciences : M/S, 2020, Volume: 36, Issue:5

    Topics: Antigen Presentation; Antigens, Neoplasm; Cross-Priming; Dendritic Cells; Humans; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Messenger

2020
Oncometabolites suppress DNA repair by disrupting local chromatin signalling.
    Nature, 2020, Volume: 582, Issue:7813

    Topics: Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; Chromatin; DNA Breaks; DNA Repair; Homologous Recombination; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine Acetyltransferase 5; Methylation; Neoplasms; Poly(ADP-ribose) Polymerase Inhibitors; Signal Transduction

2020
m
    Nature communications, 2020, 06-05, Volume: 11, Issue:1

    Topics: Animals; Cell Line, Tumor; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA Breaks, Double-Stranded; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Homologous Recombination; Humans; Methylation; Mice; Neoplasms; Poly(ADP-ribose) Polymerase Inhibitors; Rad51 Recombinase; Rad52 DNA Repair and Recombination Protein; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Small Interfering; Xenograft Model Antitumor Assays

2020
Host-Guest Protein Assembly for Affinity Purification of Methyllysine Proteomes.
    Analytical chemistry, 2020, 07-07, Volume: 92, Issue:13

    Topics: Amantadine; Bridged-Ring Compounds; Chromatography, Affinity; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; HeLa Cells; Humans; Imidazoles; Lysine; Methylation; Neoplasms; Peptides

2020
RNA N-6-methyladenosine enzymes and resistance of cancer cells to chemotherapy and radiotherapy.
    Epigenomics, 2020, Volume: 12, Issue:9

    Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Cell Cycle Proteins; Drug Resistance, Neoplasm; Humans; Methylation; Methyltransferases; Neoplasms; Radiation Tolerance; RNA; RNA Splicing Factors

2020
Ibuprofen mediates histone modification to diminish cancer cell stemness properties via a COX2-dependent manner.
    British journal of cancer, 2020, Volume: 123, Issue:5

    Topics: A549 Cells; Acetylation; Animals; Cell Line, Tumor; Cyclooxygenase 2; Drug Resistance, Neoplasm; Female; Hep G2 Cells; Histone Deacetylases; Histones; Humans; Ibuprofen; Intercellular Adhesion Molecule-3; Methylation; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Neoplasm Metastasis; Neoplasms; Neoplastic Stem Cells; Random Allocation

2020
Response to W.C. Taylor, and C. Fiala and E.P. Diamandis.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2020, Volume: 31, Issue:9

    Topics: Cell-Free Nucleic Acids; Humans; Methylation; Models, Biological; Neoplasms

2020
Recoding the Cancer Epigenome by Intervening in Metabolism and Iron Homeostasis with Mitochondria-Targeted Rhenium(I) Complexes.
    Angewandte Chemie (International ed. in English), 2020, 10-12, Volume: 59, Issue:42

    Topics: Animals; Apoptosis; Cell Line, Tumor; Coordination Complexes; Deferasirox; Drug Evaluation, Preclinical; Epigenomics; Histones; Humans; Iron; Iron Chelating Agents; Methylation; Mice; Mitochondria; Neoplasms; Reactive Oxygen Species; Receptors, Antigen, T-Cell; Rhenium; RNA Polymerase II; Signal Transduction

2020
Methio "mine"! Cancer cells steal methionine and impair CD8 T-cell function.
    Immunology and cell biology, 2020, Volume: 98, Issue:8

    Topics: CD8-Positive T-Lymphocytes; Histones; Humans; Methionine; Methylation; Neoplasms; STAT5 Transcription Factor

2020
Aspirin mediates histone methylation that inhibits inflammation-related stemness gene expression to diminish cancer stemness via COX-independent manner.
    Stem cell research & therapy, 2020, 08-27, Volume: 11, Issue:1

    Topics: Aspirin; Cell Line, Tumor; Gene Expression; Histones; Humans; Inflammation; Methylation; Neoplasms; Neoplastic Stem Cells; Phosphatidylinositol 3-Kinases

2020
Cancer SLC43A2 alters T cell methionine metabolism and histone methylation.
    Nature, 2020, Volume: 585, Issue:7824

    Topics: Amino Acid Transport System L; Animals; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Epigenesis, Genetic; Female; Histones; Humans; Methionine; Methylation; Mice; Neoplasms; Receptors, Antigen, T-Cell; STAT5 Transcription Factor

2020
Computational prediction and analysis of histone H3k27me1-associated miRNAs.
    Biochimica et biophysica acta. Proteins and proteomics, 2021, Volume: 1869, Issue:1

    Topics: Computational Biology; Computer Simulation; Gene Expression Regulation, Neoplastic; Gene Ontology; Histones; Humans; Machine Learning; Methylation; MicroRNAs; Models, Genetic; Neoplasm Proteins; Neoplasms; Signal Transduction; Transcription Factors

2021
Hsp90 regulates HDAC3-dependent gene transcription while HDAC3 regulates the functions of Hsp90.
    Cellular signalling, 2020, Volume: 76

    Topics: Acetylation; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; HSP90 Heat-Shock Proteins; Humans; MCF-7 Cells; Methylation; Neoplasms

2020
A Tug-of-War Over Methionine.
    Cell metabolism, 2020, 11-03, Volume: 32, Issue:5

    Topics: Histones; Methionine; Methylation; Neoplasms; S-Adenosylmethionine; T-Lymphocytes

2020
A role of glycation and methylation for SARS-CoV-2 infection in diabetes?
    Medical hypotheses, 2020, Volume: 144

    Topics: Adipose Tissue; Angiotensin-Converting Enzyme 2; Biomarkers; Comorbidity; COVID-19; Diabetes Complications; Diabetes Mellitus, Type 2; DNA Methylation; Glycosylation; Humans; Immunoglobulin G; Insulin Resistance; Methylation; Multicenter Studies as Topic; Neoplasms; Protein Domains; Renin-Angiotensin System; Retrospective Studies; SARS-CoV-2; Up-Regulation

2020
Regulating Tumor N
    Small (Weinheim an der Bergstrasse, Germany), 2021, Volume: 17, Issue:1

    Topics: Cell Line, Tumor; Doxorubicin; Humans; Hypoxia; Methylation; Nanoparticles; Neoplasms; Polyethylene Glycols

2021
Identification of hnRNP-A1 as a pharmacodynamic biomarker of type I PRMT inhibition in blood and tumor tissues.
    Scientific reports, 2020, 12-17, Volume: 10, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Immunological; Arginine; Biomarkers; Cells, Cultured; Chromatography, Liquid; Drug Monitoring; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Heterogeneous Nuclear Ribonucleoprotein A1; Humans; Leukocytes, Mononuclear; Mass Spectrometry; Methylation; Mice; Molecular Targeted Therapy; Neoplasms; Protein-Arginine N-Methyltransferases; Repressor Proteins; Substrate Specificity

2020
FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells.
    Cell, 2021, 01-21, Volume: 184, Issue:2

    Topics: Adult; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Breaks, Double-Stranded; DNA Replication; Drug Resistance, Neoplasm; F-Box Proteins; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Immune Checkpoint Inhibitors; Immunity; Interferons; Lysine; Male; Methylation; Middle Aged; Neoplasm Proteins; Neoplasms; Nucleosomes; Repetitive Sequences, Nucleic Acid; Signal Transduction; Transcription, Genetic; Treatment Outcome

2021
Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.
    Nature, 2021, Volume: 590, Issue:7846

    Topics: Binding Sites; Biocatalysis; Cell Line, Tumor; Cell Proliferation; Cryoelectron Microscopy; Heterografts; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Models, Molecular; Multiprotein Complexes; Mutation; Neoplasm Transplantation; Neoplasms; Nuclear Proteins; Nucleosomes; Phenotype; Protein Binding; Repressor Proteins

2021
An epigenetic tipping point in cancer comes under the microscope.
    Nature, 2021, Volume: 590, Issue:7846

    Topics: Epigenesis, Genetic; Humans; Methylation; Methyltransferases; Neoplasms; Nucleosomes

2021
Pan-cancer characterization of expression and clinical relevance of m
    Molecular cancer, 2021, 02-08, Volume: 20, Issue:1

    Topics: Adenosine; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Methylation; Neoplasm Staging; Neoplasms; Organ Specificity; Prognosis; RNA, Long Noncoding

2021
Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation.
    Proceedings of the National Academy of Sciences of the United States of America, 2021, 03-02, Volume: 118, Issue:9

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinogenesis; Cell Line; Chromatin; CRISPR-Cas Systems; Cytarabine; Decitabine; Epigenesis, Genetic; Gene Editing; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Mesenchymal Stem Cells; Methylation; Mice; Mutation; Neoplasm Proteins; Neoplasms; Phenotype; Protein Isoforms; Protein Processing, Post-Translational; Repressor Proteins; Transcriptome

2021
RNA N6-methyladenosine: a new player in autophagy-mediated anti-cancer drug resistance.
    British journal of cancer, 2021, Volume: 124, Issue:10

    Topics: Adenosine; Autophagy; Disease Progression; Drug Resistance, Neoplasm; Humans; Methylation; Methyltransferases; Neoplasms; RNA; RNA Processing, Post-Transcriptional

2021
A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation.
    Nucleic acids research, 2021, 05-07, Volume: 49, Issue:8

    Topics: Animals; Binding Sites; Enhancer Elements, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Reporter; Histone Demethylases; Histones; Homeostasis; Humans; Methylation; Mice; Neoplasms; NIH 3T3 Cells; Nucleocytoplasmic Transport Proteins; Promoter Regions, Genetic; R-Loop Structures; Recombinant Proteins; RNA Interference; Transcription, Genetic

2021
Comprehensive analyses of m6A regulators and interactive coding and non-coding RNAs across 32 cancer types.
    Molecular cancer, 2021, 04-13, Volume: 20, Issue:1

    Topics: Adenosine; Biomarkers, Tumor; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; Organ Specificity; RNA, Messenger; RNA, Untranslated

2021
Determination of Polycyclic Aromatic Hydrocarbons and Their Methylated Derivatives in Sewage Sludge from Northeastern China: Occurrence, Profiles and Toxicity Evaluation.
    Molecules (Basel, Switzerland), 2021, May-06, Volume: 26, Issue:9

    Topics: Agriculture; China; Chromatography, High Pressure Liquid; Environmental Monitoring; Methylation; Neoplasms; Polycyclic Aromatic Hydrocarbons; Quality Control; Risk Assessment; Sewage; Soil Pollutants; Toxicity Tests

2021
METTL1-mediated m
    Molecular cell, 2021, 08-19, Volume: 81, Issue:16

    Topics: Carcinogenesis; Guanosine; Humans; Methylation; Methyltransferases; Neoplasms; Oncogenes; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Transfer; tRNA Methyltransferases

2021
Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure.
    Cancer cell, 2017, 08-14, Volume: 32, Issue:2

    Topics: Animals; Antineoplastic Agents; Chromatin; Drug Resistance, Neoplasm; Epigenetic Repression; Gene Expression Regulation, Neoplastic; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Humans; Long Interspersed Nucleotide Elements; Methylation; Mice; Mice, Nude; Mice, SCID; Neoplasms; Stress, Physiological; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2017
MUC1-C activates EZH2 expression and function in human cancer cells.
    Scientific reports, 2017, 08-07, Volume: 7, Issue:1

    Topics: A549 Cells; Antigens, CD; Binding Sites; BRCA1 Protein; Cadherins; Cell Line, Tumor; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Mucin-1; Neoplasms; Promoter Regions, Genetic; Signal Transduction; Transcriptional Activation

2017
EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms.
    Oncogene, 2018, 01-25, Volume: 37, Issue:4

    Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Transformation, Neoplastic; Cytoplasm; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HEK293 Cells; Humans; Janus Kinase 2; Jurkat Cells; Methylation; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; Mutagenesis, Site-Directed; Neoplasms; Nuclear Localization Signals; Proto-Oncogene Proteins c-vav; Recombinant Proteins; STAT3 Transcription Factor; Talin; Xenograft Model Antitumor Assays

2018
Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment.
    European journal of medicinal chemistry, 2017, Nov-10, Volume: 140

    Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Demethylases; Humans; Methylation; Molecular Docking Simulation; Neoplasms; Tranylcypromine

2017
Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines.
    Biochemical and biophysical research communications, 2018, 01-01, Volume: 495, Issue:1

    Topics: Antineoplastic Agents; Carcinogens; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Humans; Isoenzymes; Lyngbya Toxins; Methylation; Neoplasms; Protein Kinase C

2018
Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway.
    PloS one, 2017, Volume: 12, Issue:11

    Topics: Apoptosis; Azepines; Cell Cycle; Cell Hypoxia; Cell Movement; Cell Proliferation; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MCF-7 Cells; Methylation; Neoplasms; Oncogenes; Prognosis; Quinazolines; Signal Transduction

2017
Genetic variants in the histone methylation and acetylation pathway and their risks in eight types of cancers.
    Journal of digestive diseases, 2018, Volume: 19, Issue:2

    Topics: Acetylation; Genetic Predisposition to Disease; Genetic Variation; Germ-Line Mutation; Histones; Humans; Methylation; Neoplasms; Polymorphism, Single Nucleotide; Signal Transduction

2018
Primary aminomethyl derivatives of kaempferol: hydrogen bond-assisted synthesis, anticancer activity and spectral properties.
    Organic & biomolecular chemistry, 2018, 03-14, Volume: 16, Issue:11

    Topics: Amination; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Hydrogen Bonding; Kaempferols; Methylation; Models, Molecular; Neoplasms

2018
N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent.
    Journal of medicinal chemistry, 2018, 03-22, Volume: 61, Issue:6

    Topics: Animals; Female; Gallium Radioisotopes; Humans; Integrin alpha5beta1; Ligands; Magnetic Resonance Spectroscopy; Melanoma, Experimental; Methylation; Mice; Mice, SCID; Models, Molecular; Molecular Structure; Neoplasms; Peptides; Positron-Emission Tomography; Protein Binding; Radioactive Tracers; Tissue Distribution; Xenograft Model Antitumor Assays

2018
Global delay in nascent strand DNA methylation.
    Nature structural & molecular biology, 2018, Volume: 25, Issue:4

    Topics: Cell Cycle; Cell Proliferation; CpG Islands; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA Replication; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Regulation; Genome, Human; HCT116 Cells; Humans; Male; Methylation; Mitosis; Motor Neurons; Neoplasms; Sequence Analysis, RNA; Transcription Factors

2018
A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.
    Molecular cell, 2018, 05-03, Volume: 70, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Differentiation; Cell Line; HEK293 Cells; Histones; Humans; Methylation; Methyltransferases; Mice; Neoplasms; Polycomb Repressive Complex 2; Repressor Proteins; Sequence Alignment; Vertebrates

2018
Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing.
    Genome medicine, 2018, 04-17, Volume: 10, Issue:1

    Topics: Alternative Splicing; Cell Line, Tumor; Cluster Analysis; Exons; Gene Expression Regulation, Neoplastic; Gene Ontology; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms; Nucleotide Motifs; Reproducibility of Results; RNA Splice Sites

2018
Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width.
    Nature communications, 2018, 05-16, Volume: 9, Issue:1

    Topics: Animals; Gene Expression Profiling; Genomics; HCT116 Cells; Histone Code; Histones; Humans; Liver; Lysine; Male; Methionine; Methylation; Mice, Inbred C57BL; Neoplasms

2018
Methylation of Aurora kinase A by MMSET reduces p53 stability and regulates cell proliferation and apoptosis.
    Oncogene, 2018, Volume: 37, Issue:48

    Topics: Apoptosis; Aurora Kinase A; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; HCT116 Cells; Histone-Lysine N-Methyltransferase; Humans; Methylation; Neoplasms; Repressor Proteins; Tumor Suppressor Protein p53

2018
[Expression changes of tumor-related gene mRNA in workers who smelt arsenic].
    Wei sheng yan jiu = Journal of hygiene research, 2018, Volume: 47, Issue:4

    Topics: Animals; Arsenic; Arsenicals; Humans; Methylation; Neoplasms; Occupational Exposure; RNA, Messenger; Spectrophotometry, Atomic

2018
Methylation and MicroRNA Profiling to Understand Racial Disparities of Prostate Cancer.
    Methods in molecular biology (Clifton, N.J.), 2018, Volume: 1856

    Topics: Biomarkers, Tumor; Cell Transformation, Neoplastic; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; High-Throughput Nucleotide Sequencing; Humans; Incidence; Male; Methylation; MicroRNAs; Neoplasms; Population Groups; Prevalence; Risk Factors

2018
Human SETMAR is a DNA sequence-specific histone-methylase with a broad effect on the transcriptome.
    Nucleic acids research, 2019, 01-10, Volume: 47, Issue:1

    Topics: Animals; DNA Transposable Elements; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Neoplasms; Primates; Signal Transduction; Transcription Factors; Transcriptome

2019
RNA Modifications: Reversal Mechanisms and Cancer.
    Biochemistry, 2019, 02-05, Volume: 58, Issue:5

    Topics: Alkylation; Epigenesis, Genetic; Humans; Methylation; Neoplasms; RNA; RNA Processing, Post-Transcriptional

2019
Identification of selective and reversible LSD1 inhibitors with anti-metastasis activity by high-throughput docking.
    Bioorganic & medicinal chemistry letters, 2019, 02-15, Volume: 29, Issue:4

    Topics: Cell Line, Tumor; Demethylation; Enzyme Inhibitors; Histone Demethylases; Histones; Humans; Lysine; Methylation; Molecular Docking Simulation; Neoplasm Metastasis; Neoplasms; Structure-Activity Relationship

2019
The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C.
    Molecular cancer therapeutics, 2019, Volume: 18, Issue:3

    Topics: Amino Acid Sequence; Bridged Bicyclo Compounds, Heterocyclic; Catalysis; Catalytic Domain; Cell Line, Tumor; Humans; Metals; Methylation; Mutagenesis, Site-Directed; Neoplasms; Nuclear Proteins; Phosphoprotein Phosphatases; Piperazines; Protein Phosphatase 2

2019
AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions.
    Nature cell biology, 2019, Volume: 21, Issue:2

    Topics: Animals; Antibiotics, Antineoplastic; Carcinogenesis; Cell Line, Tumor; Female; HEK293 Cells; Histone-Lysine N-Methyltransferase; Humans; Methylation; Mice, Nude; Mice, Transgenic; Neoplasms; Plicamycin; Protein Methyltransferases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Sf9 Cells; Spodoptera; Xenograft Model Antitumor Assays

2019
Altered Methionine Metabolism in Cancer Cells.
    Methods in molecular biology (Clifton, N.J.), 2019, Volume: 1866

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Homocysteine; Humans; Methionine; Methylation; Neoplasms; S-Adenosylhomocysteine; S-Adenosylmethionine

2019
Linkage of Methionine Dependence and Other Features of Malignancy.
    Methods in molecular biology (Clifton, N.J.), 2019, Volume: 1866

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cell Line, Tumor; Cell Proliferation; Humans; Methionine; Methylation; Neoplasms; Rats

2019
Anti-tumour immunity controlled through mRNA m
    Nature, 2019, Volume: 566, Issue:7743

    Topics: Adenosine; Animals; Antigen Presentation; Antigens, Neoplasm; B7-H1 Antigen; Binding Sites; Cathepsins; CD8-Positive T-Lymphocytes; Cross-Priming; Dendritic Cells; Female; Humans; Methylation; Mice; Mice, Inbred C57BL; Neoplasms; Protein Biosynthesis; Proteins; RNA-Binding Proteins; RNA, Messenger; Transcriptome

2019
DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns.
    Cancer cell, 2019, 02-11, Volume: 35, Issue:2

    Topics: 5-Methylcytosine; Animals; Cell Line, Tumor; CpG Islands; DNA Methylation; DNA-Binding Proteins; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Histones; Humans; Male; Methylation; Mice, Inbred C57BL; Mice, Knockout; Myeloid-Lymphoid Leukemia Protein; Neoplasm Proteins; Neoplasms; Promoter Regions, Genetic

2019
PTEN arginine methylation by PRMT6 suppresses PI3K-AKT signaling and modulates pre-mRNA splicing.
    Proceedings of the National Academy of Sciences of the United States of America, 2019, 04-02, Volume: 116, Issue:14

    Topics: Alternative Splicing; Cell Line, Tumor; HEK293 Cells; Humans; Methylation; Neoplasm Proteins; Neoplasms; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; RNA Precursors; RNA, Neoplasm; Signal Transduction

2019
The expanding landscape of 'oncohistone' mutations in human cancers.
    Nature, 2019, Volume: 567, Issue:7749

    Topics: Cell Transformation, Neoplastic; Histones; Humans; Lysine; Methylation; Mutation; Neoplasms; Nucleosomes; Protein Domains; Protein Processing, Post-Translational

2019
Translate less, prime better, to improve anti-tumor responses.
    Nature immunology, 2019, Volume: 20, Issue:5

    Topics: Dendritic Cells; HIV-1; Humans; Methylation; Neoplasms; RNA-Binding Proteins; RNA, Messenger

2019
YTHDF1 Control of Dendritic Cell Cross-Priming as a Possible Target of Cancer Immunotherapy.
    Biochemistry, 2019, 04-16, Volume: 58, Issue:15

    Topics: Cross-Priming; Dendritic Cells; Humans; Immunotherapy; Methylation; Neoplasms; RNA-Binding Proteins; RNA, Messenger

2019
Fine-tuning AKT kinase activity through direct lysine methylation.
    Cell cycle (Georgetown, Tex.), 2019, Volume: 18, Issue:9

    Topics: Animals; Carcinogenesis; Histone-Lysine N-Methyltransferase; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt

2019
PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage.
    Cancer discovery, 2019, Volume: 9, Issue:9

    Topics: Animals; Binding Sites; Cell Line, Tumor; DNA Breaks, Double-Stranded; Female; HCT116 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Mice; Neoplasms; NIH 3T3 Cells; Phosphorylation; PTEN Phosphohydrolase; Repressor Proteins; Tumor Suppressor p53-Binding Protein 1

2019
Somatic Cancer Mutations in the SUV420H1 Protein Lysine Methyltransferase Modulate Its Catalytic Activity.
    Journal of molecular biology, 2019, 08-09, Volume: 431, Issue:17

    Topics: Amino Acid Sequence; Animals; Cell Line, Tumor; DNA Repair; Fibroblasts; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Neoplasms; Nucleosomes; S-Adenosylmethionine

2019
M-TAP Dance: Targeting PRMT1 and PRMT5 Family Members to Push Cancer Cells Over the Edge.
    Cancer cell, 2019, 07-08, Volume: 36, Issue:1

    Topics: Dancing; Enzyme Inhibitors; Humans; Methylation; Neoplasms; Protein-Arginine N-Methyltransferases; Repressor Proteins

2019
Determination of the in vitro metabolic stability and metabolites of the anticancer derivative riccardin D-N in human and mouse hepatic S9 fractions using HPLC-Q-LIT-MS.
    Journal of pharmaceutical and biomedical analysis, 2019, Sep-10, Volume: 174

    Topics: Animals; Antineoplastic Agents; Calibration; Chromatography, High Pressure Liquid; Humans; Hydrogen; Hydroxylation; Liver; Methylation; Mice; Microsomes, Liver; Neoplasms; Oxygen; Phenyl Ethers; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Stilbenes

2019
Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity.
    Journal of computer-aided molecular design, 2019, Volume: 33, Issue:8

    Topics: Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Humans; Methylation; Molecular Docking Simulation; Neoplasms; Protein Binding; Protein-Arginine N-Methyltransferases; Pyrimidines; Pyrroles; Quinolines; Structure-Activity Relationship; Triazoles

2019
NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink.
    Nature chemical biology, 2013, Volume: 9, Issue:5

    Topics: Epigenesis, Genetic; Humans; Methionine; Methylation; Models, Genetic; Neoplasms; Niacinamide; Nicotinamide N-Methyltransferase

2013
Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase.
    The Journal of biological chemistry, 2013, May-24, Volume: 288, Issue:21

    Topics: Benzoquinones; Cell Line, Tumor; Enzyme Inhibitors; Enzyme Stability; Histones; HSP90 Heat-Shock Proteins; Humans; Jumonji Domain-Containing Histone Demethylases; Lactams, Macrocyclic; Methylation; Neoplasm Proteins; Neoplasms; Proteasome Endopeptidase Complex; Proteolysis; Ubiquitin

2013
Epigenomic analysis of multilineage differentiation of human embryonic stem cells.
    Cell, 2013, May-23, Volume: 153, Issue:5

    Topics: Animals; Cell Differentiation; Chromatin; CpG Islands; DNA Methylation; Embryonic Stem Cells; Epigenomics; Gene Expression Regulation, Developmental; Histones; Humans; Methylation; Neoplasms; Promoter Regions, Genetic; Zebrafish

2013
A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth.
    Nature communications, 2013, Volume: 4

    Topics: Aminopyridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Epigenesis, Genetic; Histones; Humans; Hydrazones; Inhibitory Concentration 50; Isomerism; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Neoplasms; Small Molecule Libraries; Survival Analysis; Transcription, Genetic

2013
The protein-protein interaction network of the human Sirtuin family.
    Biochimica et biophysica acta, 2013, Volume: 1834, Issue:10

    Topics: Acetylation; Aging; Computational Biology; Databases, Protein; Humans; Methylation; Neoplasms; Phosphorylation; Protein Interaction Mapping; Protein Interaction Maps; Protein Processing, Post-Translational; Sirtuins

2013
EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Actin Cytoskeleton; Adenosine; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Enhancer of Zeste Homolog 2 Protein; Epigenetic Repression; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Histones; Humans; Methylation; Neoplasms; Promoter Regions, Genetic; RNA, Messenger; Tumor Suppressor Proteins

2013
KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors.
    Cell, 2013, Aug-01, Volume: 154, Issue:3

    Topics: Chromatin; Chromosomes, Human, Pair 1; DNA Replication; Gene Dosage; Genomic Instability; HEK293 Cells; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Neoplasms; Protein Structure, Tertiary; S Phase

2013
The malignant brain tumor (MBT) domain protein SFMBT1 is an integral histone reader subunit of the LSD1 demethylase complex for chromatin association and epithelial-to-mesenchymal transition.
    The Journal of biological chemistry, 2013, Sep-20, Volume: 288, Issue:38

    Topics: Carcinogens; Chromatin; Epithelial Cells; Epithelial-Mesenchymal Transition; HEK293 Cells; Histone Demethylases; Histones; Humans; Methylation; Neoplasm Proteins; Neoplasms; Nickel; Repressor Proteins; Snail Family Transcription Factors; Trace Elements; Transcription Factors

2013
Promoter histone H3K27 methylation in the control of IGF2 imprinting in human tumor cell lines.
    Human molecular genetics, 2014, Jan-01, Volume: 23, Issue:1

    Topics: Alleles; Binding Sites; CCCTC-Binding Factor; Cell Line; Chromatin; Chromatin Immunoprecipitation; DNA Methylation; Gene Expression Regulation, Neoplastic; Genomic Imprinting; Histones; HT29 Cells; Humans; Insulin-Like Growth Factor II; Methylation; Neoplasm Proteins; Neoplasms; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Repressor Proteins; Transcription Factors

2014
p53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer.
    Cancer cell, 2013, Sep-09, Volume: 24, Issue:3

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromosomal Proteins, Non-Histone; Female; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; Peptide Chain Initiation, Translational; Prognosis; Protein Binding; Protein Biosynthesis; RNA, Ribosomal; Tumor Suppressor Protein p53

2013
Safe and easy route for the synthesis of 1,3-dimethyl-1,2,3-triazolium salt and investigation of its anticancer activities.
    Bioorganic & medicinal chemistry letters, 2013, Nov-01, Volume: 23, Issue:21

    Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; Methylation; Neoplasms; Triazoles

2013
The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.
    Molecular and cellular biology, 2013, Volume: 33, Issue:23

    Topics: Animals; DNA-Binding Proteins; Enhancer Elements, Genetic; Epigenesis, Genetic; Gene Expression; HCT116 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Mice; Neoplasms; Protein Processing, Post-Translational; Protein Transport

2013
Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Oct-15, Volume: 110, Issue:42

    Topics: HEK293 Cells; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Hydrophobic and Hydrophilic Interactions; Intracellular Signaling Peptides and Proteins; Methylation; Neoplasm Proteins; Neoplasms; Protein-Arginine N-Methyltransferases; S-Adenosylmethionine; Substrate Specificity

2013
Statistical and practical considerations for clinical evaluation of predictive biomarkers.
    Journal of the National Cancer Institute, 2013, Nov-20, Volume: 105, Issue:22

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; ErbB Receptors; Gefitinib; Glioblastoma; Humans; Indazoles; Interleukin-6; Kidney Neoplasms; Lung Neoplasms; Methylation; Molecular Targeted Therapy; Mutation; Neoplasms; Precision Medicine; Predictive Value of Tests; Pyrimidines; Quinazolines; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Sample Size; Sulfonamides; Temozolomide; Tumor Suppressor Proteins

2013
KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation.
    Oncotarget, 2013, Volume: 4, Issue:11

    Topics: Cell Growth Processes; Cell Movement; DNA-Binding Proteins; Histone Acetyltransferases; Histone Demethylases; Histones; Humans; Methylation; Neoplasm Proteins; Neoplasms; Transfection

2013
Natural variation in the histone demethylase, KDM4C, influences expression levels of specific genes including those that affect cell growth.
    Genome research, 2014, Volume: 24, Issue:1

    Topics: Cell Proliferation; Cells, Cultured; Epigenesis, Genetic; Gene Expression Regulation; Gene Knockdown Techniques; Genetic Linkage; Genetic Variation; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Neoplasms; Phenotype

2014
Lysine methylation promotes VEGFR-2 activation and angiogenesis.
    Science signaling, 2013, Dec-03, Volume: 6, Issue:304

    Topics: Animals; Cell Line, Tumor; HEK293 Cells; Heterografts; Humans; Lysine; Methylation; Mice; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Protein Processing, Post-Translational; Vascular Endothelial Growth Factor Receptor-2; Zebrafish; Zebrafish Proteins

2013
2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes.
    European journal of medicinal chemistry, 2014, Mar-21, Volume: 75

    Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Halogenation; Humans; Methylation; Molecular Docking Simulation; Neoplasms; Quinoxalines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase

2014
Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway.
    Nature communications, 2014, Mar-17, Volume: 5

    Topics: Cell Line, Tumor; Down-Regulation; Glucose; Glycolysis; Heme Oxygenase (Decyclizing); Humans; Methylation; Neoplasms; Oxidative Stress; Pentose Phosphate Pathway; Phosphofructokinase-2

2014
S-score: a scoring system for the identification and prioritization of predicted cancer genes.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Computational Biology; DNA Copy Number Variations; Female; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Genomics; Humans; Methylation; Mutation; Neoplasms; Oncogenes

2014
Enhanced arginine methylation of programmed cell death 4 protein during nutrient deprivation promotes tumor cell viability.
    The Journal of biological chemistry, 2014, Jun-20, Volume: 289, Issue:25

    Topics: Apoptosis Regulatory Proteins; Arginine; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasm Proteins; Neoplasms; Phosphorylation; Protein-Arginine N-Methyltransferases; RNA-Binding Proteins; Up-Regulation

2014
Biological evaluation and SAR analysis of O-methylated analogs of quercetin as inhibitors of cancer cell proliferation.
    Drug development research, 2014, Volume: 75, Issue:7

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Methylation; Molecular Structure; Neoplasms; Quercetin; Structure-Activity Relationship

2014
Polycomb repressive complex 2 and H3K27me3 cooperate with H3K9 methylation to maintain heterochromatin protein 1α at chromatin.
    Molecular and cellular biology, 2014, Oct-01, Volume: 34, Issue:19

    Topics: Animals; Cell Cycle; Cell Line, Tumor; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Histones; Humans; Methylation; Mice; Models, Molecular; Neoplasms; Polycomb Repressive Complex 2; Proteasome Endopeptidase Complex; Protein Stability

2014
Synthesis and cytotoxic activity of 1-{3-[1-(5-organylsilylfuran-2-yl)silinan-1-yl]propyl}amines and some trimethylgermyl analogues.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2014, Sep-26, Volume: 20, Issue:40

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Germanium; Humans; Methylation; Mice; Neoplasms; NIH 3T3 Cells; Organosilicon Compounds

2014
Synthesis of IB-01212 by multiple N-methylations of peptide bonds.
    Bioorganic & medicinal chemistry, 2014, Nov-01, Volume: 22, Issue:21

    Topics: Amino Acid Sequence; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Depsipeptides; Humans; Methylation; Neoplasms

2014
Enzymatic methylation and structure-activity-relationship studies on polycarcin V, a gilvocarcin-type antitumor agent.
    Chembiochem : a European journal of chemical biology, 2014, Dec-15, Volume: 15, Issue:18

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Coumarins; Glycosides; Humans; Methylation; Neoplasms; Streptomyces; Structure-Activity Relationship

2014
Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2.
    Journal of medicinal chemistry, 2014, Nov-26, Volume: 57, Issue:22

    Topics: Astemizole; Binding, Competitive; Catalysis; Catalytic Domain; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Progression; Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Lymphoma; Magnetic Resonance Spectroscopy; Methylation; Models, Molecular; Molecular Docking Simulation; Neoplasms; Polycomb Repressive Complex 2; Protein Interaction Mapping; Protein Processing, Post-Translational

2014
Total syntheses and biological evaluation of miuraenamides.
    Angewandte Chemie (International ed. in English), 2015, Apr-07, Volume: 54, Issue:15

    Topics: Actins; Antineoplastic Agents; Cell Line, Tumor; Depsipeptides; Humans; Methylation; Neoplasms; Oxidation-Reduction

2015
Somatic cancer mutations in the DNMT2 tRNA methyltransferase alter its catalytic properties.
    Biochimie, 2015, Volume: 112

    Topics: Amino Acid Substitution; Animals; Catalysis; DNA (Cytosine-5-)-Methyltransferases; Humans; Methylation; Mice; Mutation, Missense; Neoplasm Proteins; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Transfer, Asp

2015
3-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, nortopsentin analogues with antiproliferative activity.
    Marine drugs, 2015, Apr-03, Volume: 13, Issue:4

    Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Design; G2 Phase; Halogenation; Humans; Imidazoles; Indoles; Membrane Potential, Mitochondrial; Methylation; Mitochondria; Molecular Structure; Neoplasms; Pyridines; Pyrroles; Resting Phase, Cell Cycle; Thiazoles

2015
Comparative methylome analysis in solid tumors reveals aberrant methylation at chromosome 6p in nasopharyngeal carcinoma.
    Cancer medicine, 2015, Volume: 4, Issue:7

    Topics: Carcinoma; Chromosomes, Human, Pair 6; Computational Biology; CpG Islands; DNA Methylation; Epigenesis, Genetic; Epigenomics; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Meta-Analysis as Topic; Methylation; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms; Promoter Regions, Genetic; Transcriptome

2015
Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives.
    Journal of medicinal chemistry, 2015, Jun-11, Volume: 58, Issue:11

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Catechin; Cell Proliferation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavonols; Humans; Methylation; Models, Molecular; Molecular Structure; Neoplasm Proteins; Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured

2015
Structure-activity relationship studies of 4-methylcoumarin derivatives as anticancer agents.
    Pharmaceutical biology, 2016, Volume: 54, Issue:1

    Topics: Antineoplastic Agents; Cell Survival; Coumarins; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; K562 Cells; MCF-7 Cells; Methylation; Molecular Structure; Neoplasms; Structure-Activity Relationship

2016
SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells.
    Oncotarget, 2015, Jul-10, Volume: 6, Issue:19

    Topics: Animals; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histone-Lysine N-Methyltransferase; Humans; Immunoprecipitation; Mass Spectrometry; Methylation; Mice; Neoplasms; Protein Processing, Post-Translational; Real-Time Polymerase Chain Reaction; Ubiquitination

2015
Epigenetic reprogramming in solid tumors: therapeutic implications of EZH2 gain-of-function mutations.
    Epigenomics, 2015, Volume: 7, Issue:5

    Topics: Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Methylation; Molecular Targeted Therapy; Mutation; Neoplasms; Polycomb Repressive Complex 2

2015
Development-linked changes in DNA methylation and hydroxymethylation in humans: interview with Dr Melanie Ehrlich.
    Epigenomics, 2015, Volume: 7, Issue:5

    Topics: 5-Methylcytosine; DNA Methylation; Epigenesis, Genetic; Epigenomics; History, 20th Century; History, 21st Century; Humans; Methylation; Neoplasms; Organ Specificity

2015
Application of Celluclast 1.5L in apple pectin extraction.
    Carbohydrate polymers, 2015, Dec-10, Volume: 134

    Topics: Acetylation; Antineoplastic Agents, Phytogenic; Antioxidants; Biocatalysis; Caco-2 Cells; Cell Movement; Cell Proliferation; Chemical Fractionation; Hexuronic Acids; Humans; Malus; Methylation; Neoplasms; Pectins

2015
Alternative transcription initiation leads to expression of a novel ALK isoform in cancer.
    Nature, 2015, Oct-15, Volume: 526, Issue:7573

    Topics: Alleles; Anaplastic Lymphoma Kinase; Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Histones; Humans; Introns; Isoenzymes; Lysine; Methylation; Mice; Molecular Sequence Data; Molecular Weight; Neoplasms; NIH 3T3 Cells; Oncogenes; Protein Structure, Tertiary; Receptor Protein-Tyrosine Kinases; RNA Polymerase II; RNA, Messenger; Signal Transduction; Transcription Initiation, Genetic

2015
PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP.
    Oncotarget, 2015, Nov-03, Volume: 6, Issue:34

    Topics: Amino Acid Sequence; Arginine; Cell Line, Tumor; Chromosomal Proteins, Non-Histone; HEK293 Cells; HeLa Cells; Humans; Methylation; Mitosis; Molecular Sequence Data; Neoplasms; Protein-Arginine N-Methyltransferases; Repressor Proteins; Transfection

2015
Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2.
    Science (New York, N.Y.), 2015, Oct-16, Volume: 350, Issue:6258

    Topics: Allosteric Regulation; Amino Acid Sequence; Catalysis; Catalytic Domain; Chaetomium; Crystallography, X-Ray; Fungal Proteins; Gene Silencing; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Molecular Sequence Data; Mutation; Neoplasms; Polycomb Repressive Complex 2; Protein Structure, Tertiary; S-Adenosylhomocysteine; Transcription, Genetic

2015
LncRNA ontology: inferring lncRNA functions based on chromatin states and expression patterns.
    Oncotarget, 2015, Nov-24, Volume: 6, Issue:37

    Topics: Algorithms; Cell Line; Cell Line, Tumor; Cells, Cultured; Chromatin; Gene Expression Profiling; Gene Ontology; Gene Regulatory Networks; HeLa Cells; Hep G2 Cells; Histones; Humans; K562 Cells; Lysine; Methylation; Models, Genetic; Neoplasms; Promoter Regions, Genetic; RNA, Long Noncoding; RNA, Messenger; Transcription Initiation Site

2015
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2.
    Nature medicine, 2015, Volume: 21, Issue:12

    Topics: Acetylation; Animals; Catalysis; Cell Line, Tumor; Chromosomal Proteins, Non-Histone; Drug Resistance, Neoplasm; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Female; Humans; Indoles; Methylation; Mice, Nude; Mutation; Neoplasms; Phosphorylation; Polycomb Repressive Complex 2; Pyridones; RNA, Small Interfering; Transcription Factors; Xenograft Model Antitumor Assays

2015
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
    Cancer cell, 2015, Nov-09, Volume: 28, Issue:5

    Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice, Inbred BALB C; Mice, Nude; Molecular Sequence Data; Neoplasms; Nuclear Proteins; Nucleotides; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleoside Diphosphate Reductase; RNA Interference; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Xenograft Model Antitumor Assays

2015
Flat SAR of P3-methylsulphonamide based small molecule legumain inhibitors.
    Bioorganic & medicinal chemistry letters, 2016, Jan-15, Volume: 26, Issue:2

    Topics: Animals; Cysteine Endopeptidases; Drug Design; Humans; Methylation; Mice; Neoplasms; Protease Inhibitors; Rats; Small Molecule Libraries; Structure-Activity Relationship; Sulfonamides

2016
Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis.
    Nature communications, 2016, Jan-13, Volume: 7

    Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Gene Knock-In Techniques; HEK293 Cells; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Methylation; Mice; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Protein Methyltransferases; Protein Processing, Post-Translational; Protein Stability; Retinal Neovascularization; Retinopathy of Prematurity; Reverse Transcriptase Polymerase Chain Reaction

2016
Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy.
    European journal of medicinal chemistry, 2016, Apr-13, Volume: 112

    Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Halogenation; Histone Deacetylase Inhibitors; Humans; Ketones; Methylation; Neoplasms; Structure-Activity Relationship; Thiazoles; Zinc

2016
A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression.
    Oncogene, 2017, 01-19, Volume: 36, Issue:3

    Topics: A549 Cells; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenocarcinoma of Lung; Arginine; Breast Neoplasms; Carcinoma, Squamous Cell; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Lung Neoplasms; MCF-7 Cells; Methylation; Neoplasm Invasiveness; Neoplasms; Prognosis; Protein-Arginine N-Methyltransferases; Sequence Analysis, RNA; Transcription, Genetic; Transforming Growth Factor beta

2017
IDH1, Histone Methylation, and So Forth.
    Cancer cell, 2016, 08-08, Volume: 30, Issue:2

    Topics: DNA Methylation; Histones; Humans; Isocitrate Dehydrogenase; Methylation; Mutation; Neoplasms

2016
Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation.
    The Journal of biological chemistry, 2016, Sep-30, Volume: 291, Issue:40

    Topics: Enzyme Stability; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Methyltransferases; Mutation; Neoplasm Proteins; Neoplasms; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Structure-Activity Relationship

2016
A New Chromatin-Cytoskeleton Link in Cancer.
    Molecular cancer research : MCR, 2016, Volume: 14, Issue:12

    Topics: Chromatin; Cytoskeleton; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Tubulin

2016
Nephrotoxicity of epigenetic inhibitors used for the treatment of cancer.
    Chemico-biological interactions, 2016, Oct-25, Volume: 258

    Topics: Acetylation; Animals; Antineoplastic Agents; Azacitidine; Cell Death; Cell Line, Tumor; Cell Proliferation; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Docetaxel; Epigenesis, Genetic; HEK293 Cells; Histones; Humans; Hydroxamic Acids; Kidney; Male; Methylation; Neoplasms; Oligopeptides; Prostatic Neoplasms; Rats; Taxoids

2016
Knockout of arsenic (+3 oxidation state) methyltransferase results in sex-dependent changes in phosphatidylcholine metabolism in mice.
    Archives of toxicology, 2016, Volume: 90, Issue:12

    Topics: Animals; Arsenic; Arsenic Poisoning; Arsenites; Biotransformation; Carcinogens, Environmental; Female; Liver; Male; Methylation; Methyltransferases; Mice, Inbred C57BL; Mice, Knockout; Neoplasms; Phosphatidylcholines; Sex Characteristics

2016
Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.
    Nature cell biology, 2016, Volume: 18, Issue:10

    Topics: Animals; DNA Methylation; Glutamine; Histone Demethylases; Histones; Humans; Ketoglutaric Acids; Methylation; Methyltransferases; Neoplasms

2016
SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1.
    Oncotarget, 2016, Nov-15, Volume: 7, Issue:46

    Topics: Cell Membrane; Enzyme Activation; Gene Expression; Gene Knockdown Techniques; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Neoplasms; Phosphorylation; Pleckstrin Homology Domains; Proto-Oncogene Proteins c-akt; Signal Transduction; Tyrosine

2016
Mechanistic and biological characteristics of different sugar conjugated 2-methyl malonatoplatinum(II) complexes as new tumor targeting agents.
    European journal of medicinal chemistry, 2017, Jan-05, Volume: 125

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Drug Screening Assays, Antitumor; Glucose Transport Proteins, Facilitative; Glycoconjugates; Humans; Male; Methylation; Mice; Neoplasms; Organoplatinum Compounds; Oxaliplatin

2017
Alteration of histone H3 lysine 9 dimethylation in peripheral white blood cells of septic patients with trauma and cancer.
    Molecular medicine reports, 2016, Volume: 14, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; C-Reactive Protein; Female; Fluorescent Antibody Technique; Histones; Humans; Leukocytes; Lysine; Male; Methylation; Middle Aged; Neoplasms; ROC Curve; Sepsis; Wounds and Injuries

2016
Unique Triphenylphosphonium Derivatives for Enhanced Mitochondrial Uptake and Photodynamic Therapy.
    Bioconjugate chemistry, 2017, 02-15, Volume: 28, Issue:2

    Topics: Cell Line; Drug Carriers; Fluoresceins; Halogenation; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Methylation; Microscopy, Confocal; Microscopy, Fluorescence; Mitochondria; Neoplasms; Organophosphorus Compounds; Photochemotherapy; Photosensitizing Agents; Thermodynamics

2017
Emerging links between m
    Genome medicine, 2017, 01-12, Volume: 9, Issue:1

    Topics: Adenosine; Animals; Humans; Methylation; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Messenger

2017
Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer.
    Nature, 2017, 02-23, Volume: 542, Issue:7642

    Topics: beta-Transducin Repeat-Containing Proteins; Breast Neoplasms; Cell Line, Tumor; Chromatin Assembly and Disassembly; DNA Helicases; DNA-Binding Proteins; Female; Gene Expression Regulation, Neoplastic; Genes, Essential; Glycogen Synthase Kinase 3 beta; Histones; Humans; Lysine; Male; Methylation; Molecular Targeted Therapy; Neoplasms; NF-kappa B; Phosphorylation; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Protein Stability; Proteolysis; PTEN Phosphohydrolase; Tumor Necrosis Factor-alpha; Ubiquitination

2017
Distribution bias analysis of germline and somatic single-nucleotide variations that impact protein functional site and neighboring amino acids.
    Scientific reports, 2017, 02-08, Volume: 7

    Topics: Acetylation; Catalytic Domain; Databases, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Ontology; Germ-Line Mutation; Glycosylation; Humans; Methylation; Molecular Sequence Annotation; Neoplasm Proteins; Neoplasms; Phosphorylation; Polymorphism, Single Nucleotide; Protein Processing, Post-Translational; Survival Analysis; Ubiquitination

2017
Chromatin reader ZMYND8 is a key target of all trans retinoic acid-mediated inhibition of cancer cell proliferation.
    Biochimica et biophysica acta. Gene regulatory mechanisms, 2017, Volume: 1860, Issue:4

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Chromatin; Chromatin Immunoprecipitation; Fluorescent Antibody Technique; Histone Deacetylases; Histones; Humans; Lysine; Methylation; Mice; Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic; Receptors for Activated C Kinase; Receptors, Cell Surface; Response Elements; RNA Polymerase II; Time Factors; Tretinoin; Tumor Suppressor Proteins; YY1 Transcription Factor

2017
Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation.
    Scientific reports, 2017, 03-03, Volume: 7

    Topics: Crystallography, X-Ray; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Mutant Proteins; Mutation, Missense; Neoplasms; Protein Binding; Protein Conformation; Protein Processing, Post-Translational

2017
Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives.
    Bioorganic & medicinal chemistry letters, 2017, 04-15, Volume: 27, Issue:8

    Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Survival; Drug Design; Drug Screening Assays, Antitumor; Humans; Methylation; Neoplasms; Piperazine; Piperazines; Sulfones

2017
Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor.
    Journal of molecular biology, 2008, Jul-04, Volume: 380, Issue:2

    Topics: Apoptosis; Crystallography, X-Ray; DNA Repair; Histones; Humans; Inhibitor of Growth Protein 1; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutation; Neoplasms; Nuclear Proteins; Peptides; Protein Array Analysis; Protein Binding; Protein Structure, Tertiary; Tumor Suppressor Proteins

2008
Relationship between the methylation status of dietary flavonoids and their growth-inhibitory and apoptosis-inducing activities in human cancer cells.
    Journal of cellular biochemistry, 2008, Oct-01, Volume: 105, Issue:2

    Topics: Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Diet; Flavonoids; G1 Phase; Humans; Methylation; Neoplasms; Poly(ADP-ribose) Polymerases; Structure-Activity Relationship

2008
Synthesis and utilization of chiral alpha-methylated alpha-amino acids with a carboxyalkyl side chain in the design of novel Grb2-SH2 peptide inhibitors free of phosphotyrosine.
    Journal of medicinal chemistry, 2008, Oct-23, Volume: 51, Issue:20

    Topics: Alkylation; Amino Acids; Carboxylic Acids; Cell Line, Tumor; Cell Proliferation; Drug Design; GRB2 Adaptor Protein; Humans; Methylation; Neoplasms; Peptides; Phosphorylation; src Homology Domains; Stereoisomerism; Structure-Activity Relationship

2008
Requirement of RIZ1 for cancer prevention by methyl-balanced diet.
    PloS one, 2008, Volume: 3, Issue:10

    Topics: Animals; Diet; DNA-Binding Proteins; Food; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Methionine; Methylation; Mice; Mice, Knockout; Neoplasms; Nuclear Proteins; S-Adenosylmethionine; Transcription Factors

2008
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer.
    Science (New York, N.Y.), 2008, Dec-12, Volume: 322, Issue:5908

    Topics: 3' Untranslated Regions; Algorithms; Breast Neoplasms; Cell Line, Tumor; Disease Progression; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genome, Human; Histones; Humans; Lysine; Male; Methylation; MicroRNAs; Neoplasm Metastasis; Neoplasms; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Prostatic Neoplasms; RNA, Small Interfering; Stomach Neoplasms; Transcription Factors

2008
p53 methylation--the Arg-ument is clear.
    Cell cycle (Georgetown, Tex.), 2009, Mar-15, Volume: 8, Issue:6

    Topics: Animals; Arginine; DNA Damage; Humans; Methylation; Neoplasms; Phosphorylation; Protein Methyltransferases; Protein Processing, Post-Translational; Tumor Suppressor Protein p53

2009
Incorporation of 5-chlorocytosine into mammalian DNA results in heritable gene silencing and altered cytosine methylation patterns.
    Carcinogenesis, 2009, Volume: 30, Issue:5

    Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Cytosine; DNA; DNA Damage; DNA Replication; Gene Silencing; Glycine; Humans; Inflammation; Mammals; Methylation; Neoplasms; Oligonucleotides

2009
Macroscopic differences in HMGA oncoproteins post-translational modifications: C-terminal phosphorylation of HMGA2 affects its DNA binding properties.
    Journal of proteome research, 2009, Volume: 8, Issue:6

    Topics: Amino Acid Sequence; Cell Line, Tumor; Chromatography, Liquid; HMGA Proteins; HMGA2 Protein; HMGN Proteins; Humans; Mass Spectrometry; Methylation; Molecular Sequence Data; Neoplasms; Phosphorylation; Protein Binding; Protein Interaction Mapping; Protein Processing, Post-Translational; Sequence Alignment; Serine

2009
PRIP promotes tumor formation through enhancing serum-responsive factor-mediated FOS expression.
    The Journal of biological chemistry, 2009, May-22, Volume: 284, Issue:21

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Mammary Neoplasms, Animal; Methylation; Mice; Mice, Knockout; Neoplasms; Nuclear Receptor Coactivators; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-fos; ras Proteins; Serum Response Factor

2009
DNA methylation and histone modification regulate silencing of OPG during tumor progression.
    Journal of cellular biochemistry, 2009, Sep-01, Volume: 108, Issue:1

    Topics: Cell Line, Tumor; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Histones; Humans; Male; Methylation; Neoplasms; Osteoprotegerin; Prostatic Neoplasms

2009
Arginine methylation regulates telomere length and stability.
    Molecular and cellular biology, 2009, Volume: 29, Issue:18

    Topics: Amino Acid Sequence; Amino Acid Substitution; Arginine; Cell Line; Cell Proliferation; Cellular Senescence; Chromatin Immunoprecipitation; Humans; Methylation; Molecular Sequence Data; Neoplasms; Protein Binding; Protein Structure, Tertiary; Protein-Arginine N-Methyltransferases; Repressor Proteins; Structure-Activity Relationship; Telomere; Telomeric Repeat Binding Protein 2

2009
Reprogramming of HeLa cells upon DNMT3L overexpression mimics carcinogenesis.
    Epigenetics, 2009, Jul-01, Volume: 4, Issue:5

    Topics: Cell Proliferation; Cell Shape; Cellular Reprogramming; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression Regulation, Neoplastic; Genome, Human; HeLa Cells; Histones; Humans; Methylation; Molecular Mimicry; Neoplasms; Pluripotent Stem Cells; Promoter Regions, Genetic; Tumor Stem Cell Assay

2009
Polymorphisms in arsenic metabolism genes, urinary arsenic methylation profile and cancer.
    Cancer causes & control : CCC, 2009, Volume: 20, Issue:9

    Topics: Arsenic; Arsenic Poisoning; Chromatography, High Pressure Liquid; Female; Genetic Predisposition to Disease; Humans; Incidence; Male; Methylation; Neoplasms; Polymorphism, Single Nucleotide; Taiwan; Water Pollutants, Chemical

2009
Epigenetic information in chromatin and cancer.
    European journal of cancer (Oxford, England : 1990), 2009, Volume: 45 Suppl 1

    Topics: Acetylation; Chromatin; DNA Repair; Epigenesis, Genetic; Histones; Humans; Methylation; Neoplasms; Transcription, Genetic

2009
A pharmacokinetic and safety study of intravenous arsenic trioxide in adult cancer patients with renal impairment.
    Cancer chemotherapy and pharmacology, 2010, Volume: 66, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Area Under Curve; Arsenic Trioxide; Arsenicals; Biotransformation; Female; Humans; Karnofsky Performance Status; Kidney Diseases; Male; Methylation; Middle Aged; Neoplasms; Oxides

2010
Label-free analysis of DNA methylation using optofluidic ring resonators.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2009, Volume: 2009

    Topics: Animals; Cell Proliferation; Cytosine; DNA Methylation; Epigenesis, Genetic; Equipment Design; Humans; Methylation; Mice; Neoplasms; Nucleic Acid Hybridization; Oligonucleotides; Optics and Photonics

2009
G9a and Glp methylate lysine 373 in the tumor suppressor p53.
    The Journal of biological chemistry, 2010, Mar-26, Volume: 285, Issue:13

    Topics: Autoantigens; DNA Damage; DNA Methylation; Gene Expression Regulation; Golgi Matrix Proteins; Histocompatibility Antigens; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Neoplasms; Peptides; Protein Processing, Post-Translational; Proteins; Recombinant Proteins; RNA, Small Interfering; Tumor Suppressor Protein p53

2010
The histone demethylase UTX enables RB-dependent cell fate control.
    Genes & development, 2010, Feb-15, Volume: 24, Issue:4

    Topics: Animals; Caenorhabditis elegans; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Chromatin; Gene Expression Regulation; Genome; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Mice; Neoplasms; Retinoblastoma Binding Proteins

2010
Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity.
    Nature cell biology, 2010, Volume: 12, Issue:3

    Topics: Acetylation; Cell Line, Tumor; Chromatin Assembly and Disassembly; Computational Biology; CpG Islands; Databases, Genetic; DNA Methylation; Down-Regulation; Embryonic Stem Cells; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes; Genome, Human; Histones; Humans; Loss of Heterozygosity; Male; Methylation; MicroRNAs; Multigene Family; Neoplasms; Promoter Regions, Genetic; Prostatic Neoplasms; RNA, Messenger; Transcription, Genetic; Up-Regulation

2010
Close encounters: RIDGEs, hyperacetylated chromatin, radiation breakpoints and genes differentially expressed in tumors cluster at specific human chromosome regions.
    Cytogenetic and genome research, 2010, Volume: 128, Issue:1-3

    Topics: Animals; Chromatin; Chromosomes, Human; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms

2010
Hypoxia-inducible factor (HIF)-3alpha is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2.
    The international journal of biochemistry & cell biology, 2010, Volume: 42, Issue:7

    Topics: Alternative Splicing; Apoptosis Regulatory Proteins; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1; Methylation; Mutant Proteins; Neoplasms; Repressor Proteins; RNA, Messenger; Transcription Initiation Site; Transcription, Genetic

2010
Tumor suppression by the histone demethylase UTX.
    Cell cycle (Georgetown, Tex.), 2010, Jun-01, Volume: 9, Issue:11

    Topics: Animals; Drosophila; Drosophila Proteins; G1 Phase; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Neoplasms; Nuclear Proteins; Oxidoreductases, N-Demethylating; Retinoblastoma Binding Proteins; Retinoblastoma Protein; S Phase

2010
Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice.
    The Journal of biological chemistry, 2010, Sep-03, Volume: 285, Issue:36

    Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Cell Cycle; Chromatin; Cyclin E; Gene Expression Regulation; Gene Knockout Techniques; Growth and Development; HeLa Cells; Histones; Humans; Longevity; Lymphopoiesis; Lysine; Male; Methylation; Mice; Molecular Sequence Data; Neoplasms; Nuclear Proteins; Repressor Proteins; Survival Rate; Tumor Suppressor Proteins

2010
Negative regulation of hypoxic responses via induced Reptin methylation.
    Molecular cell, 2010, Jul-09, Volume: 39, Issue:1

    Topics: Animals; ATPases Associated with Diverse Cellular Activities; Carrier Proteins; Cell Hypoxia; Cell Line; DNA Helicases; Female; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysine; Methylation; Mice; Models, Biological; Neoplasms; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Protein Binding; Xenograft Model Antitumor Assays

2010
Replication stress, a source of epigenetic aberrations in cancer?
    BioEssays : news and reviews in molecular, cellular and developmental biology, 2010, Volume: 32, Issue:10

    Topics: Chromatin; Chromosome Aberrations; DNA Replication; Epigenesis, Genetic; Epigenomics; Histones; Methylation; Neoplasms; Nuclear Proteins

2010
Heterochromatin silencing of p53 target genes by a small viral protein.
    Nature, 2010, Aug-26, Volume: 466, Issue:7310

    Topics: Adenoviridae; Cell Proliferation; Cells, Cultured; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; HCT116 Cells; Heterochromatin; Histones; Humans; Methylation; Neoplasms; Oncogene Proteins, Viral; Protein Binding; Tumor Suppressor Protein p53; Virus Replication

2010
Carboxymethylated polyvinyl alcohol stabilizes doped ferrofluids for biological applications.
    Advanced materials (Deerfield Beach, Fla.), 2010, Dec-01, Volume: 22, Issue:45

    Topics: Cell Line, Tumor; Ferric Compounds; Humans; Hydrogen-Ion Concentration; Magnetics; Manganese Compounds; Methylation; Nanoparticles; Nanotechnology; Neoplasms; Osmolar Concentration; Polyvinyl Alcohol; Temperature

2010
The influence of methylation on carcinogenic activity; N-methyl-3 : 4 : 5 : 6-dibenzcarbazole.
    British journal of experimental pathology, 1946, Volume: 27

    Topics: Carcinogens; Humans; Methylation; Neoplasms

1946
Multi-cancer computational analysis reveals invasion-associated variant of desmoplastic reaction involving INHBA, THBS2 and COL11A1.
    BMC medical genomics, 2010, Nov-03, Volume: 3

    Topics: Collagen Type XI; Computational Biology; Fibroblasts; Humans; Inhibin-beta Subunits; Methylation; MicroRNAs; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Neoplasms; Thrombospondins; Treatment Outcome

2010
Immunohistochemical detection of arginine methylated proteins (MeRP) in archival tissues.
    Histopathology, 2010, Volume: 57, Issue:5

    Topics: Antibodies; Antibody Specificity; Arginine; Immunohistochemistry; Methylation; Neoplasms; Paraffin Embedding; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Proteins

2010
Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells.
    Cancer research, 2011, Feb-01, Volume: 71, Issue:3

    Topics: Animals; Cell Cycle; Histone Demethylases; Humans; Methylation; Mice; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Neoplasms; Oxidoreductases, N-Demethylating; Retinoblastoma Protein

2011
Lysine methylation of promoter-bound transcription factors and relevance to cancer.
    Cell research, 2011, Volume: 21, Issue:3

    Topics: DNA; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Neoplasms; NF-kappa B; Promoter Regions, Genetic; STAT3 Transcription Factor

2011
Down-regulation of the tumor suppressor C-terminal Src kinase (Csk)-binding protein (Cbp)/PAG1 is mediated by epigenetic histone modifications via the mitogen-activated protein kinase (MAPK)/phosphatidylinositol 3-kinase (PI3K) pathway.
    The Journal of biological chemistry, 2011, May-06, Volume: 286, Issue:18

    Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Transformation, Neoplastic; Embryo, Mammalian; Epigenesis, Genetic; Fibroblasts; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histones; Humans; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Membrane Proteins; Methylation; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoproteins; Protein Processing, Post-Translational; Proto-Oncogene Proteins pp60(c-src); ras Proteins; Tumor Suppressor Proteins

2011
Radiosynthesis of [11C]Vandetanib and [11C]chloro-Vandetanib as new potential PET agents for imaging of VEGFR in cancer.
    Bioorganic & medicinal chemistry letters, 2011, Jun-01, Volume: 21, Issue:11

    Topics: Carbon Radioisotopes; Chlorine; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Methylation; Molecular Structure; Neoplasms; Piperidines; Positron-Emission Tomography; Quinazolines; Radiopharmaceuticals; Receptors, Vascular Endothelial Growth Factor

2011
Homeobox gene Rhox5 is regulated by epigenetic mechanisms in cancer and stem cells and promotes cancer growth.
    Molecular cancer, 2011, May-24, Volume: 10

    Topics: Animals; Benzamides; Cell Differentiation; Cell Line, Tumor; Cell Movement; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Homeodomain Proteins; Humans; Methylation; Mice; Mice, Nude; Neoplasms; Promoter Regions, Genetic; Pyridines; RNA, Messenger; Stem Cells; Transcription Factors; Tretinoin; Tumor Burden; Xenograft Model Antitumor Assays

2011
Synthesis and biological evaluation of the 12,12-dimethyl derivative of Aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin.
    Bioscience, biotechnology, and biochemistry, 2011, Volume: 75, Issue:6

    Topics: Anticarcinogenic Agents; Antigens, Viral; B-Lymphocytes; Carcinogens; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Epstein-Barr Virus Infections; Furans; Herpesvirus 4, Human; Humans; Hydrophobic and Hydrophilic Interactions; Lyngbya Toxins; Methylation; Neoplasms; Phorbol Esters; Protein Binding; Protein Kinase C-delta; Spiro Compounds; Structure-Activity Relationship

2011
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Aug-16, Volume: 108, Issue:33

    Topics: Animals; Enzyme Inhibitors; Epigenomics; Histone Demethylases; Histones; Methylation; Mice; Mice, Knockout; Neoplasms; Proto-Oncogene Proteins; Retinoblastoma Protein; Retinol-Binding Proteins, Cellular; Survival Rate

2011
Novel positron emission tomography tracer distinguishes normal from cancerous cells.
    The Journal of biological chemistry, 2011, Sep-30, Volume: 286, Issue:39

    Topics: Cell Division; Cell Line, Tumor; Deoxyuracil Nucleotides; DNA Replication; DNA, Neoplasm; Humans; Methylation; Neoplasm Proteins; Neoplasms; Positron-Emission Tomography; Radioactive Tracers; Radiography; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase

2011
Structure of human SMYD2 protein reveals the basis of p53 tumor suppressor methylation.
    The Journal of biological chemistry, 2011, Nov-04, Volume: 286, Issue:44

    Topics: Calorimetry; Cell Line, Tumor; Crystallography, X-Ray; Genes, Tumor Suppressor; Histone-Lysine N-Methyltransferase; Histones; Humans; Kinetics; Lysine; Methylation; Molecular Conformation; Neoplasms; Protein Binding; Transcription, Genetic; Tumor Suppressor Protein p53

2011
Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties.
    Cancer research, 2011, Dec-01, Volume: 71, Issue:23

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Embryonic Stem Cells; Epigenomics; HEK293 Cells; HeLa Cells; Histone Demethylases; Histones; Humans; Methylation; Mice; Neoplasms; NIH 3T3 Cells; Octamer Transcription Factor-3; Pluripotent Stem Cells; RNA Interference; Sensitivity and Specificity; SOXB1 Transcription Factors

2011
Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway.
    Neoplasia (New York, N.Y.), 2011, Volume: 13, Issue:10

    Topics: beta Catenin; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HCT116 Cells; HEK293 Cells; Hep G2 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunohistochemistry; Lung Neoplasms; Methylation; Neoplasms; Oligonucleotide Array Sequence Analysis; Protein Binding; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tissue Array Analysis; Urinary Bladder Neoplasms; Wnt Signaling Pathway

2011
SMYD3 promotes cancer invasion by epigenetic upregulation of the metalloproteinase MMP-9.
    Cancer research, 2012, Feb-01, Volume: 72, Issue:3

    Topics: Animals; Blotting, Western; Cattle; Cell Line, Tumor; Cell Proliferation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Host-Parasite Interactions; Humans; Matrix Metalloproteinase 9; Methylation; Neoplasm Invasiveness; Neoplasm Transplantation; Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Theileria; Theileriasis; Transplantation, Heterologous; Up-Regulation; Zebrafish

2012
Genetic discoveries propagate new epigenetic drugs.
    Journal of the National Cancer Institute, 2012, Feb-08, Volume: 104, Issue:3

    Topics: Animals; Antineoplastic Agents; Epigenesis, Genetic; Histones; Humans; Methylation; Mutation; Neoplasms

2012
Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo.
    Food & function, 2012, Volume: 3, Issue:6

    Topics: Animals; Biological Availability; Catechin; Catechol O-Methyltransferase; Cell Line, Tumor; Down-Regulation; Humans; Male; Methylation; Mice; Mice, SCID; Neoplasms; Polyphenols; Quercetin; Tea; Up-Regulation

2012
Computational identification and modeling of crosstalk between phosphorylation, O-β-glycosylation and methylation of FoxO3 and implications for cancer therapeutics.
    International journal of molecular sciences, 2012, Volume: 13, Issue:3

    Topics: Amino Acid Sequence; Forkhead Box Protein O3; Forkhead Transcription Factors; Glycosylation; Humans; Methylation; Models, Molecular; Molecular Sequence Data; Neoplasms; Phosphorylation; Phosphotyrosine; Protein Kinases

2012
Relevance of histone marks H3K9me3 and H4K20me3 in cancer.
    Anticancer research, 2012, Volume: 32, Issue:5

    Topics: Acetyltransferases; Adult; Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; CA-19-9 Antigen; Carcinoembryonic Antigen; Female; Histones; Humans; Male; Methylation; Middle Aged; Neoplasms; Nucleosomes

2012
Molecular biology. Genetic events that shape the cancer epigenome.
    Science (New York, N.Y.), 2012, Jun-22, Volume: 336, Issue:6088

    Topics: Chromatin; DNA Methylation; Enhancer Elements, Genetic; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genome, Human; Histones; Humans; Methylation; Mutation; Neoplasms; Promoter Regions, Genetic; Transcription Factors; Transcription, Genetic

2012
Chromatin organization is a major influence on regional mutation rates in human cancer cells.
    Nature, 2012, Aug-23, Volume: 488, Issue:7412

    Topics: Animals; CpG Islands; Epigenesis, Genetic; Euchromatin; Genome, Human; Heterochromatin; Histones; Humans; Leukemia; Lung Neoplasms; Male; Melanoma; Methylation; Mutagenesis; Mutation Rate; Neoplasms; Pan troglodytes; Polymorphism, Single Nucleotide; Principal Component Analysis; Prostatic Neoplasms; Small Cell Lung Carcinoma

2012
T-ARG-eting E2F-1 growth control.
    Cell cycle (Georgetown, Tex.), 2012, Aug-15, Volume: 11, Issue:16

    Topics: Animals; Apoptosis; Arginine; E2F1 Transcription Factor; Gene Expression Regulation, Neoplastic; Methylation; Mice; Neoplasms; Protein Methyltransferases; Protein-Arginine N-Methyltransferases; Tumor Suppressor Protein p53; Ubiquitination

2012
Induction of aberrant trimethylation of histone H3 lysine 27 by inflammation in mouse colonic epithelial cells.
    Carcinogenesis, 2012, Volume: 33, Issue:12

    Topics: Aging; Animals; Apoptosis Regulatory Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Colitis; Colon; Death-Associated Protein Kinases; Dextran Sulfate; Epithelial Cells; Gene Expression; Histones; Intestinal Mucosa; Lysine; Male; Methylation; Mice; Mice, Inbred BALB C; Neoplasms

2012
TreeVis: a MATLAB-based tool for tree visualization.
    Computer methods and programs in biomedicine, 2013, Volume: 109, Issue:1

    Topics: Algorithms; Cell Line, Tumor; Computational Biology; Computer Graphics; Genome, Human; Humans; Methylation; Neoplasms; Software; User-Computer Interface

2013
Human RNA methyltransferase BCDIN3D regulates microRNA processing.
    Cell, 2012, Oct-12, Volume: 151, Issue:2

    Topics: Cell Line, Tumor; DEAD-box RNA Helicases; Humans; MCF-7 Cells; Methylation; Methyltransferases; MicroRNAs; Neoplasms; Ribonuclease III; RNA Processing, Post-Transcriptional

2012
Chd5 requires PHD-mediated histone 3 binding for tumor suppression.
    Cell reports, 2013, Jan-31, Volume: 3, Issue:1

    Topics: Amino Acid Sequence; Animals; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; DNA Helicases; Genetic Loci; Genome; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Mice; Models, Molecular; Molecular Sequence Data; Mutation; Neoplasms; Neuroblastoma; Peptides; Protein Binding; Structure-Activity Relationship

2013
Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells.
    Nucleic acids research, 2002, Nov-01, Volume: 30, Issue:21

    Topics: Acetylation; Cadherins; Chromatin; Chromosomal Proteins, Non-Histone; CpG Islands; DNA Methylation; DNA-Binding Proteins; Gene Silencing; Histones; Humans; Lysine; Methyl-CpG-Binding Protein 2; Methylation; Neoplasms; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; Tumor Cells, Cultured

2002
NSD1 is essential for early post-implantation development and has a catalytically active SET domain.
    The EMBO journal, 2003, Jun-16, Volume: 22, Issue:12

    Topics: Amino Acid Sequence; Animals; Apoptosis; Carrier Proteins; Chromosomes, Human, Pair 5; Embryo, Mammalian; Embryonic Development; Female; Gene Targeting; Genes, Reporter; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; In Situ Hybridization; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Male; Mesoderm; Methylation; Methyltransferases; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Neoplasms; Nuclear Proteins; Pregnancy; Protein Methyltransferases; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Alignment

2003
METHYLATION OF RIBONUCLEIC ACIDS OF LIVER AND OTHER ORGANS IN DIFFERENT SPECIES TREATED WITH C14- AND H3-DIMETHYLNITROSAMINES IN VIVO.
    Journal of the National Cancer Institute, 1964, Volume: 32

    Topics: Animals; Carbon Isotopes; Carcinogens; Chemical and Drug Induced Liver Injury; Chromatography; Cricetinae; Dimethylnitrosamine; Guanine; Guinea Pigs; Hepatitis; Kidney; Liver; Methylation; Mice; Neoplasms; Nitrosamines; Nucleotides; Proteins; Pyrimidines; Rats; Research; RNA; Spleen; Toxicology; Tritium

1964
METHYLATION OF LIVER DNA IN THE INTACT ANIMAL BY THE CARCINOGEN DIMETHYLNITROSAMINE DURING CARCINOGENESIS.
    Biochimica et biophysica acta, 1965, Apr-19, Volume: 95

    Topics: Alkylation; Animals; Carbon Isotopes; Carcinogenesis; Carcinogens; Diet; Dimethylnitrosamine; DNA; Liver; Metabolism; Methylation; Neoplasms; Nitrosamines; Rats; Research

1965
Fighting cancer by disrupting C-terminal methylation of signaling proteins.
    The Journal of clinical investigation, 2004, Volume: 113, Issue:4

    Topics: Animals; Methylation; Neoplasms; Protein Methyltransferases; Protein Prenylation; Proteins; ras Proteins; Signal Transduction

2004
Three dimensional analysis of histone methylation patterns in normal and tumor cell nuclei.
    European journal of histochemistry : EJH, 2004, Volume: 48, Issue:1

    Topics: Cell Line, Tumor; Cell Nucleus; Centromere; DNA; Female; Fibroblasts; Heterochromatin; Histones; Humans; Lysine; Methylation; Monocytes; Neoplasms; T-Lymphocytes

2004
Arginine methylation of STAT1: a reassessment.
    Cell, 2004, Nov-24, Volume: 119, Issue:5

    Topics: Arginine; Artifacts; DNA-Binding Proteins; Humans; Interferons; Methylation; Methyltransferases; Mutation; Neoplasms; Reproducibility of Results; STAT1 Transcription Factor; Trans-Activators

2004
Epigenotyping as a tool for the prediction of tumor risk and tumor type in patients with Beckwith-Wiedemann syndrome (BWS).
    The Journal of pediatrics, 2004, Volume: 145, Issue:6

    Topics: Beckwith-Wiedemann Syndrome; Child, Preschool; France; Genes, Wilms Tumor; Genotype; Humans; Incidence; Kidney Neoplasms; Membrane Proteins; Methylation; Neoplasms; Netherlands; Potassium Channels, Voltage-Gated; Predictive Value of Tests; Risk Factors; Wilms Tumor

2004
Urinary trivalent methylated arsenic species in a population chronically exposed to inorganic arsenic.
    Environmental health perspectives, 2005, Volume: 113, Issue:3

    Topics: Adolescent; Adult; Arsenic Poisoning; Arsenicals; Cacodylic Acid; Cross-Sectional Studies; Environmental Exposure; Female; Humans; Male; Methylation; Mexico; Middle Aged; Neoplasms; Risk Assessment; Water Supply

2005
Trimethylated chitosans as non-viral gene delivery vectors: cytotoxicity and transfection efficiency.
    Journal of controlled release : official journal of the Controlled Release Society, 2005, Apr-18, Volume: 103, Issue:3

    Topics: Animals; Cell Line, Tumor; Cell Survival; Chitosan; Chlorocebus aethiops; COS Cells; DNA; Dose-Response Relationship, Drug; Excipients; Female; Gene Transfer Techniques; Genes, Reporter; Humans; Luciferases; Methylation; Neoplasms; Transfection

2005
Developmental biology. Combing over the Polycomb group proteins.
    Science (New York, N.Y.), 2005, Apr-29, Volume: 308, Issue:5722

    Topics: Animals; Chromatin; DNA-Directed RNA Polymerases; Dosage Compensation, Genetic; Drosophila; Drosophila Proteins; Gene Expression Regulation, Developmental; Gene Silencing; Histones; Humans; Male; Methylation; Mutation; Neoplasms; Nucleosomes; Pluripotent Stem Cells; Polycomb Repressive Complex 1; Polycomb-Group Proteins; Prostatic Neoplasms; Proteins; Repressor Proteins; Transcription, Genetic; Ubiquitin

2005
Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives.
    Bioorganic & medicinal chemistry, 2005, Nov-01, Volume: 13, Issue:21

    Topics: Cell Line, Tumor; Cell Proliferation; Flavones; Flavonoids; Humans; Isoflavones; Methylation; Molecular Structure; Neoplasms; Oximes; Platelet Aggregation; Structure-Activity Relationship

2005
Patterns of global DNA and histone methylation appear to be similar in normal, dysplastic and neoplastic oral epithelium of humans.
    Disease markers, 2005, Volume: 21, Issue:3

    Topics: Aged; Antibodies, Monoclonal; Carcinoma, Squamous Cell; Case-Control Studies; DNA; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Epithelium; Gene Silencing; Histones; Humans; Immunohistochemistry; Male; Methylation; Middle Aged; Mouth Neoplasms; Neoplasms

2005
G3139 and other CpG-containing immunostimulatory phosphorothioate oligodeoxynucleotides are potent suppressors of the growth of human tumor xenografts in nude mice.
    Oligonucleotides, 2006,Spring, Volume: 16, Issue:1

    Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Antineoplastic Agents; B-Lymphocytes; Carcinoma; Cell Line, Tumor; Cytosine; Female; Humans; Lung Neoplasms; Lymphocyte Activation; Methylation; Mice; Mice, Nude; Neoplasms; Oligodeoxyribonucleotides; Ovarian Neoplasms; Proto-Oncogene Proteins c-bcl-2; Thionucleotides; Xenograft Model Antitumor Assays

2006
Biological evaluation of bishydroxymethyl-substituted cage dimeric 1,4-dihydropyridines as a novel class of p-glycoprotein modulating agents in cancer cells.
    Journal of medicinal chemistry, 2006, May-04, Volume: 49, Issue:9

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Proliferation; Dihydropyridines; Dimerization; Hydroxylation; Methylation; Mice; Molecular Structure; Neoplasms; Structure-Activity Relationship

2006
The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors.
    Current biology : CB, 2006, May-23, Volume: 16, Issue:10

    Topics: Alternative Splicing; Amino Acid Sequence; Animals; Carcinoma, Squamous Cell; Cell Cycle; Cell Nucleolus; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; Mice; Mice, Nude; Mice, Transgenic; Molecular Sequence Data; Multigene Family; Neoplasms; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc; RNA; RNA Interference; RNA Polymerase III; Transcription, Genetic; Transplantation, Heterologous; Up-Regulation

2006
DNA mismatch repair as an effector for promoting phorbol ester-induced apoptotic DNA damage and cell killing: implications in tumor promotion.
    International journal of cancer, 2006, Oct-15, Volume: 119, Issue:8

    Topics: Apoptosis; Azacitidine; Base Pair Mismatch; Cell Line, Tumor; CpG Islands; Decitabine; DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; Humans; Methylation; Neoplasms; Phorbol Esters; Protein Kinase C; Protein Kinase Inhibitors; Reactive Oxygen Species

2006
[Cancer epigenetics].
    Zhonghua bing li xue za zhi = Chinese journal of pathology, 2006, Volume: 35, Issue:5

    Topics: Animals; Chromatin Assembly and Disassembly; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; MicroRNAs; Neoplasms

2006
Can the state of cancer chemotherapy resistance be reverted by epigenetic therapy?
    Molecular cancer, 2006, Jul-10, Volume: 5

    Topics: Acetylation; Animals; Antineoplastic Agents; Chromatin; DNA Methylation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Models, Theoretical; Neoplasms

2006
Urinary arsenic methylation and porphyrin profile of C57Bl/6J mice chronically exposed to sodium arsenate.
    The Science of the total environment, 2007, Jul-01, Volume: 379, Issue:2-3

    Topics: Animals; Arsenates; Arsenic; Biomarkers; Carcinogens; Female; Methylation; Mice; Mice, Inbred C57BL; Neoplasms; Porphyrins

2007
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer.
    Nature genetics, 2007, Volume: 39, Issue:2

    Topics: Caco-2 Cells; Carrier Proteins; Cells, Cultured; Colonic Neoplasms; CpG Islands; DNA Methylation; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms; Viral Envelope Proteins

2007
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.
    Genes & development, 2007, Mar-01, Volume: 21, Issue:5

    Topics: Animals; Cell Line; Cellular Senescence; Chromatin Immunoprecipitation; Cyclin-Dependent Kinase Inhibitor p16; DNA-Binding Proteins; Down-Regulation; Embryo, Mammalian; Enhancer of Zeste Homolog 2 Protein; Fibroblasts; Genes, p16; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Mice; Mice, Inbred C57BL; Neoplasms; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Proteins; Proto-Oncogene Proteins; Repressor Proteins; Stem Cells; Transcription Factors; Tumor Suppressor Protein p14ARF

2007
Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Jul-24, Volume: 104, Issue:30

    Topics: Calcium; Cell Line, Tumor; Chromosomes, Human, Pair 12; CpG Islands; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Methylation; Neoplasms; Phenotype; ras GTPase-Activating Proteins; ras Proteins

2007
It takes a village to develop biomarkers.
    Journal of proteome research, 2007, Volume: 6, Issue:9

    Topics: Biomarkers, Tumor; Humans; Methylation; Neoplasms; Proteins; Proteomics; Research; United States

2007
Differentially expressed genes are marked by histone 3 lysine 9 trimethylation in human cancer cells.
    Oncogene, 2008, Apr-10, Volume: 27, Issue:17

    Topics: Cell Line, Tumor; DNA Methylation; Gene Expression Regulation, Neoplastic; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Myeloid Ecotropic Viral Integration Site 1 Protein; Neoplasm Proteins; Neoplasms; Otx Transcription Factors; Transcription, Genetic

2008
Carcinogenesis and the hypothesis of phylogenetic reversion.
    Analytical and quantitative cytology and histology, 2007, Volume: 29, Issue:6

    Topics: Animals; Cell Transformation, Neoplastic; Chemoprevention; CpG Islands; Gene Silencing; Humans; Karyometry; Methylation; Neoplasms; Phylogeny

2007
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.
    Bioorganic & medicinal chemistry, 2008, Apr-01, Volume: 16, Issue:7

    Topics: Benzenesulfonamides; Binding Sites; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cytosol; Humans; Hydrocarbons, Chlorinated; Isoenzymes; Methylation; Models, Molecular; Molecular Sequence Data; Molecular Structure; Neoplasms; Protein Folding; Sequence Alignment; Structure-Activity Relationship; Sulfhydryl Compounds; Sulfonamides

2008
COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro.
    Molecular cancer, 2008, May-16, Volume: 7

    Topics: Celecoxib; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Humans; Immunoblotting; Methylation; Neoplasms; Pyrazoles; Sulfonamides; Transcription Factor CHOP

2008
Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: XII mutational and non-mutational mechanism as subsets of a more general mechanism. Part A--Ethionine.
    Medical hypotheses, 1984, Volume: 15, Issue:3

    Topics: alpha-Fetoproteins; Animals; Carcinogens; DNA, Neoplasm; Embryo, Mammalian; Ethionine; Gene Expression Regulation; Humans; Methylation; Neoplasm Proteins; Neoplasms; S-Adenosylmethionine

1984
Hypomethylation of DNA in human cancer cells: a site-specific change in the c-myc oncogene.
    Journal of the National Cancer Institute, 1984, Volume: 73, Issue:5

    Topics: Base Sequence; Cell Line; DNA Restriction Enzymes; DNA, Neoplasm; Glioma; Humans; Lung Neoplasms; Melanoma; Methylation; Neoplasms; Oncogenes

1984
Hypomethylation distinguishes genes of some human cancers from their normal counterparts.
    Nature, 1983, Jan-06, Volume: 301, Issue:5895

    Topics: Aged; Base Sequence; Colonic Neoplasms; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA Restriction Enzymes; Female; Genes; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Neoplasms

1983
Hypomethylation of ras oncogenes in primary human cancers.
    Biochemical and biophysical research communications, 1983, Feb-28, Volume: 111, Issue:1

    Topics: Adenocarcinoma; Carcinoma, Small Cell; Colonic Neoplasms; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA Restriction Enzymes; DNA, Neoplasm; Humans; Lung Neoplasms; Methylation; Neoplasms; Nucleic Acid Hybridization; Oncogenes; Polymorphism, Genetic

1983
Multivariate analysis of urinary RNA catabolites in malignancies: cross-sectional and longitudinal studies.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1983, Volume: 84

    Topics: Analysis of Variance; Autoanalysis; Breast Neoplasms; Female; Humans; Kidney Neoplasms; Longitudinal Studies; Lung Neoplasms; Lymphoma; Male; Methylation; Neoplasms; Prostatic Neoplasms; Ribonucleosides; RNA

1983
Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains.
    Nature, 1980, Dec-25, Volume: 288, Issue:5792

    Topics: Adenoviruses, Human; Cells, Cultured; DNA Repair; Guanine; Humans; Methylation; Methylnitronitrosoguanidine; Neoplasms; Simian virus 40; Sister Chromatid Exchange

1980
The 5-methylcytosine content of DNA from human tumors.
    Nucleic acids research, 1983, Oct-11, Volume: 11, Issue:19

    Topics: 5-Methylcytosine; Brain Chemistry; Cytosine; DNA; DNA Restriction Enzymes; DNA, Neoplasm; Female; Humans; Methylation; Neoplasms; Placenta; Pregnancy; Structure-Activity Relationship

1983
Effect of 2'-O-methylation on the structure of mammalian 5.8S rRNAs and the 5.8S-28S rRNA junction.
    Nucleic acids research, 1983, Sep-10, Volume: 11, Issue:17

    Topics: Animals; Base Sequence; Cell Line; Cricetinae; Cricetulus; Female; Liver; Methylation; Molecular Weight; Neoplasms; Nucleic Acid Conformation; Nucleic Acid Denaturation; Ovary; Pancreas; Rats; Ribonuclease T1; RNA, Ribosomal

1983
Ethanol and dimethylnitrosamine and diethylnitrosamine metabolism and disposition in the rat. Possible relevance to the influence of ethanol on human cancer incidence.
    Carcinogenesis, 1984, Volume: 5, Issue:10

    Topics: Alkylation; Animals; Carbon Dioxide; Dimethylnitrosamine; DNA; Drug Interactions; Esophageal Neoplasms; Esophagus; Ethanol; Female; Humans; Methylation; Neoplasms; Rats; Rats, Inbred Strains

1984
Toward a universal tumour marker.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 1984, Volume: 5, Issue:1

    Topics: Amino Acids; Asbestosis; Chorionic Gonadotropin; DNA, Neoplasm; Female; Humans; Hydatidiform Mole; Lung Neoplasms; Mesothelioma; Methylation; Neoplasm Proteins; Neoplasms; Nucleosides; Pregnancy; RNA, Neoplasm; RNA, Transfer; Uterine Neoplasms

1984
DNA methylation by N-nitrosomethylbenzylamine in target and non-target tissues of laboratory rodents. Comparison with carcinogenicity.
    IARC scientific publications, 1984, Issue:57

    Topics: Animals; Dimethylnitrosamine; DNA; DNA, Neoplasm; Female; Inactivation, Metabolic; Male; Methylation; Mice; Neoplasms; Organ Specificity; Rats; Rats, Inbred Strains

1984
Expression of cellular oncogenes in human malignancies.
    Science (New York, N.Y.), 1984, Apr-20, Volume: 224, Issue:4646

    Topics: Adenocarcinoma; Breast Neoplasms; Carcinogens; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Female; Gastrointestinal Neoplasms; Gene Amplification; Genes, Viral; Genital Neoplasms, Female; Humans; Kidney Neoplasms; Leukemia; Lymphoma; Methylation; Mutation; Neoplasms; Nucleic Acid Hybridization; Oncogenes; RNA, Messenger; RNA, Neoplasm; Sarcoma; Transcription, Genetic; Translocation, Genetic

1984
Extent of DNA methylation in human tumor cells.
    Journal of the National Cancer Institute, 1983, Volume: 71, Issue:4

    Topics: 5-Methylcytosine; Base Composition; Cell Line; Chromatography, High Pressure Liquid; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; Gene Expression Regulation; Humans; Methylation; Methyltransferases; Neoplasms

1983
Importance of non-genetic mechanisms in carcinogenicity.
    Developments in toxicology and environmental science, 1983, Volume: 11

    Topics: Animals; Biphenyl Compounds; DNA; DNA Repair; DNA Replication; Humans; Kinetics; Male; Methylation; Neoplasms; Oncogenes; Oxygen; Rats; Urinary Bladder Neoplasms

1983
Comparison of repair of O6-methylguanine produced by N-methyl-N'-nitro-N-nitrosoguanidine in mouse and human cells.
    Carcinogenesis, 1984, Volume: 5, Issue:5

    Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; DNA Repair; Embryo, Mammalian; Female; Guanine; Humans; Kinetics; Methylation; Methylnitronitrosoguanidine; Mice; Mice, Inbred Strains; Neoplasms; Neoplasms, Experimental; Species Specificity

1984
Methylation of the O6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents.
    Cancer investigation, 1984, Volume: 2, Issue:3

    Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Guanine; Humans; Liver; Methylation; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Pyrimidines; Structure-Activity Relationship

1984
tRNA alterations in cancer.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1983, Volume: 84

    Topics: Animals; Base Sequence; Female; Humans; Liver; Liver Neoplasms, Experimental; Methylation; Neoplasms; Nucleic Acid Conformation; Placenta; Pregnancy; Rats; Ribonucleosides; RNA, Neoplasm; RNA, Transfer

1983
New applications of urinary nucleoside markers.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1983, Volume: 84

    Topics: Adult; Aging; Burkitt Lymphoma; Child; Child, Preschool; Female; Humans; Infant; Male; Methylation; Neoplasms; Nucleosides; Reference Values; RNA, Neoplasm; RNA, Transfer; Sex Factors

1983
Theoretical mechanism for synthesis of carcinogen induced embryonic proteins: VIII. Transcriptional theory.
    Medical hypotheses, 1982, Volume: 9, Issue:2

    Topics: Animals; Carcinoembryonic Antigen; Chromatin; DNA; Gene Expression Regulation; Heterochromatin; Humans; Methylation; Neoplasms; Phenotype; Transcription, Genetic

1982
Arsenic risk assessment.
    Environmental health perspectives, 1994, Volume: 102, Issue:4

    Topics: Arsenic; Bias; Carcinogens, Environmental; Decontamination; Dose-Response Relationship, Drug; Environmental Exposure; Environmental Monitoring; Epidemiological Monitoring; Humans; Linear Models; Methylation; Neoplasms; Nutritional Status; Risk Assessment; Taiwan; United States; United States Environmental Protection Agency; Water Pollutants, Chemical

1994
A cytosine methyltransferase converts 5-methylcytosine in DNA to thymine.
    Biochemistry, 1995, Nov-14, Volume: 34, Issue:45

    Topics: 5-Methylcytosine; Cytosine; DNA; DNA-Cytosine Methylases; Escherichia coli; Humans; Methylation; Molecular Structure; Mutagenesis; Neoplasms; S-Adenosylhomocysteine; S-Adenosylmethionine; Thymine

1995
Methylation and p16: suppressing the suppressor.
    Nature medicine, 1995, Volume: 1, Issue:7

    Topics: 5-Methylcytosine; Carrier Proteins; Cell Transformation, Neoplastic; Cocarcinogenesis; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Cytosine; DNA; Gene Expression Regulation; Genes, Tumor Suppressor; Genomic Imprinting; Humans; Methylation; Models, Genetic; Neoplasms

1995
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.
    Nature medicine, 1995, Volume: 1, Issue:7

    Topics: 5-Methylcytosine; Alleles; Azacitidine; Base Sequence; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carrier Proteins; Chromosomes, Human, Pair 9; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Cytosine; Decitabine; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Glioma; Head and Neck Neoplasms; Humans; Lung Neoplasms; Methylation; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Sequence Deletion; Transcription, Genetic; Tumor Cells, Cultured

1995
Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers.
    Oncogene, 1995, Apr-20, Volume: 10, Issue:8

    Topics: Base Sequence; Codon; Genes, p53; Humans; Methylation; Molecular Sequence Data; Mutation; Neoplasms; Oligonucleotides; Organ Specificity; Polymerase Chain Reaction

1995
Demethylation of a repetitive DNA sequence in human cancers.
    Electrophoresis, 1995, Volume: 16, Issue:2

    Topics: Base Sequence; Blotting, Southern; Cloning, Molecular; Colonic Neoplasms; Deoxyribonucleases, Type II Site-Specific; DNA, Neoplasm; Electrophoresis; Female; Genetic Techniques; Humans; Melanoma; Methylation; Molecular Sequence Data; Neoplasms; Pancreatic Neoplasms; Placenta; Pregnancy; Repetitive Sequences, Nucleic Acid; Tumor Cells, Cultured

1995
Hypomethylation of DNA: a possible nongenotoxic mechanism underlying the role of cell proliferation in carcinogenesis.
    Environmental health perspectives, 1993, Volume: 101 Suppl 5

    Topics: 5-Methylcytosine; Animals; Cell Division; Cytosine; DNA; Female; Liver Neoplasms, Experimental; Male; Methylation; Mice; Neoplasms; Proto-Oncogenes

1993
Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer.
    Molecular and cellular biology, 1994, Volume: 14, Issue:6

    Topics: Base Sequence; Blotting, Southern; Bone Neoplasms; Carcinoma, Transitional Cell; Cell Line; Codon; Dinucleoside Phosphates; DNA; DNA, Neoplasm; Fetus; Genes, p53; Humans; Introns; Lymphocytes; Male; Methylation; Molecular Sequence Data; Muscles; Neoplasms; Osteosarcoma; Point Mutation; Polymerase Chain Reaction; Spermatozoa; Transfection; Tumor Cells, Cultured; Urinary Bladder Neoplasms

1994
[Parent imprinting: methylation-epigenetic heredity].
    Pathologie-biologie, 1993, Volume: 41, Issue:8

    Topics: Chromosome Aberrations; Chromosome Disorders; Female; Gene Expression Regulation; Genes; Genetic Diseases, Inborn; Humans; Male; Methylation; Neoplasms

1993
Genomic imprinting and gene activation in cancer.
    Nature genetics, 1993, Volume: 4, Issue:2

    Topics: Alleles; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Methylation; Models, Genetic; Neoplasms; Neoplastic Syndromes, Hereditary; Oncogenes; Philadelphia Chromosome; Transcriptional Activation

1993
Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains.
    The Journal of biological chemistry, 1993, Oct-05, Volume: 268, Issue:28

    Topics: Amino Acid Sequence; Animals; Blood; CHO Cells; Cloning, Molecular; Cricetinae; DNA; DNA Repair; Drug Resistance; HeLa Cells; Humans; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Molecular Sequence Data; Mutagens; Neoplasms; Nucleic Acid Hybridization; Phenotype; Sequence Homology, Amino Acid; Transfection

1993
The role of DNA methylation in the expression of parathyroid hormone-related protein in humoral hypercalcaemia of malignancy.
    Biochemical Society transactions, 1993, Volume: 21, Issue:1

    Topics: DNA, Neoplasm; Gene Expression; Humans; Hypercalcemia; Methylation; Neoplasms; Parathyroid Hormone-Related Protein; Proteins

1993
Genes, chromosomes and cancer. First meeting of the "Arbeitsgemeinschaft Molekular- und Zytogenetik (AEK)" of the Deutsche Krebsgesellschaft.
    Journal of cancer research and clinical oncology, 1993, Volume: 119, Issue:7

    Topics: Animals; Chromosome Aberrations; Humans; Methylation; Neoplasm Metastasis; Neoplasms; Oncogenes; Recombination, Genetic; Virus Integration

1993
Developmental regulation of myeloid gene expression and demethylation during ex vivo culture of peripheral blood progenitor cells.
    Blood, 1996, Jan-15, Volume: 87, Issue:2

    Topics: Antigens, CD34; Biomarkers; Cell Differentiation; Cells, Cultured; DNA; DNA (Cytosine-5-)-Methyltransferases; Gene Expression Regulation, Developmental; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Interleukins; Methylation; Muramidase; Neoplasms; Peroxidase; Recombinant Proteins; Stem Cell Factor

1996
Hypomethylation of DNA: a nongenotoxic mechanism involved in tumor promotion.
    Toxicology letters, 1995, Volume: 82-83

    Topics: Animals; Base Sequence; DNA; Genes, ras; Humans; Methylation; Mice; Molecular Sequence Data; Neoplasms; Risk Assessment

1995
The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Jul-09, Volume: 93, Issue:14

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Azacitidine; Base Sequence; Decitabine; Dinucleoside Phosphates; DNA; DNA Modification Methylases; DNA Primers; DNA Probes; DNA, Neoplasm; Enzyme Inhibitors; Genome, Human; Humans; Male; Melanoma; Melanoma-Specific Antigens; Methylation; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; T-Lymphocytes, Cytotoxic; Transcription, Genetic; Tumor Cells, Cultured

1996
Issues in arsenic cancer risk assessment.
    Environmental health perspectives, 1996, Volume: 104, Issue:10

    Topics: Arsenic; Dose-Response Relationship, Drug; Food Contamination; Humans; Methylation; Neoplasms; Protein Deficiency; Risk; Taiwan; Water Pollutants, Chemical

1996
Toxicologists shed new light on old poisons.
    Science (New York, N.Y.), 1998, Mar-20, Volume: 279, Issue:5358

    Topics: Animals; Arsenicals; Carcinogens; Female; Humans; Malaria; Male; Mercury; Methylation; Neoplasms; Toxicology

1998
Arsenic-laced water in Chile.
    Science (New York, N.Y.), 1998, Aug-07, Volume: 281, Issue:5378

    Topics: Arsenic; Case-Control Studies; Chile; Humans; Lung Neoplasms; Methylation; Neoplasms; Risk Factors; Urinary Bladder Neoplasms; Water Pollutants, Chemical

1998
Suicide prodrugs activated by thymidylate synthase: rationale for treatment and noninvasive imaging of tumors with deoxyuridine analogues.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:8

    Topics: Animals; Arabinofuranosyluracil; Cell Division; DNA; Floxuridine; Fluorine Radioisotopes; Humans; Methylation; Mice; Neoplasms; Phosphorylation; Prodrugs; Thymidylate Synthase; Tumor Cells, Cultured

1999
BRCA1 and E-cadherin promoter hypermethylation and gene inactivation in cancer-association or mechanism?
    Journal of the National Cancer Institute, 2000, Apr-05, Volume: 92, Issue:7

    Topics: Breast Neoplasms; Cadherins; Female; Gene Expression Regulation, Neoplastic; Genes, BRCA1; Humans; Loss of Heterozygosity; Methylation; Mutation; Neoplasms; Ovarian Neoplasms; Promoter Regions, Genetic; Stomach Neoplasms

2000
Aberrant methylation of gene promoters in cancer---concepts, misconcepts, and promise.
    Journal of the National Cancer Institute, 2000, Sep-20, Volume: 92, Issue:18

    Topics: Animals; Biomarkers, Tumor; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Methylation; Neoplasms; Promoter Regions, Genetic; Up-Regulation

2000
Arsenic species that cause release of iron from ferritin and generation of activated oxygen.
    Archives of biochemistry and biophysics, 2000, Oct-15, Volume: 382, Issue:2

    Topics: Animals; Arsenates; Arsenic; Arsenicals; Arsenites; Cacodylic Acid; Carcinogens; Cattle; Ferritins; Glutathione; Horses; Humans; In Vitro Techniques; Iron; Kinetics; Methylation; Neoplasms; Reactive Oxygen Species

2000
Behind the scenes of gene expression.
    Science (New York, N.Y.), 2001, Aug-10, Volume: 293, Issue:5532

    Topics: Acetylation; Animals; Chromatin; DNA Methylation; Female; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Developmental; Genes, Tumor Suppressor; Genomic Imprinting; Histones; Humans; Male; Methylation; Multigene Family; Neoplasms

2001
Association of blood arsenic levels with increased reactive oxidants and decreased antioxidant capacity in a human population of northeastern Taiwan.
    Environmental health perspectives, 2001, Volume: 109, Issue:10

    Topics: Adult; Aged; Antioxidants; Arsenic; Arteriosclerosis; Environmental Pollutants; Female; Humans; Male; Methylation; Middle Aged; Neoplasms; Oxidative Stress; Reactive Oxygen Species; Taiwan

2001
A dysmethylation syndrome, bound to folates and/or vitamin B12 and/or methionine abnormalities? Diagnosis, prevention and treatment considerations.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2001, Volume: 55, Issue:8

    Topics: DNA Methylation; Folic Acid Deficiency; Hematologic Diseases; Humans; Hyperhomocysteinemia; Iatrogenic Disease; Methionine; Methylation; Neoplasms; Nervous System Diseases; Selenium; Vascular Diseases; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency

2001
Molecular analysis of cancer. An overview.
    Methods in molecular medicine, 2002, Volume: 68

    Topics: Humans; In Situ Hybridization, Fluorescence; Methylation; Mutation; Neoplasms; Oligonucleotide Array Sequence Analysis; Sequence Analysis, DNA; Telomerase

2002
Detection of aberrant methylation of the p15INK4B gene promoter.
    Methods in molecular medicine, 2002, Volume: 68

    Topics: Blotting, Southern; Cell Cycle Proteins; CpG Islands; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; DNA Primers; Exons; Genes, Tumor Suppressor; Humans; Methylation; Molecular Structure; Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic; Tumor Suppressor Proteins

2002
High-resolution liquid chromatographic analysis of methylated purine and pyrimidine bases in transfer RNA.
    Journal of chromatography, 1976, Jan-07, Volume: 116, Issue:1

    Topics: Adenine; Animals; Cattle; Chemical Phenomena; Chemistry; Chromatography, Liquid; Cytosine; Guanine; Hydrogen-Ion Concentration; Hypoxanthines; Liver; Methylation; Neoplasms; Rats; RNA, Transfer

1976
Replicational fidelity: mechanisms of mutation avoidance and mutation fixation.
    Cold Spring Harbor symposia on quantitative biology, 1979, Volume: 43 Pt 2

    Topics: Animals; Cells, Cultured; DNA Repair; DNA Replication; Escherichia coli; Exonucleases; Gene Conversion; Methylation; Mutation; Neoplasms; Pyrimidine Dimers; Recombination, Genetic; Templates, Genetic

1979
A new theory of carcinogenesis.
    British journal of cancer, 1979, Volume: 40, Issue:4

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; DNA Repair; Genes; Humans; Methylation; Methyltransferases; Mutagens; Mutation; Neoplasms; Phenotype; Probability

1979
Summation: molecular mechanisms of gene regulation--session 3.
    Cancer research, 1976, Volume: 36, Issue:11 Pt. 2

    Topics: Animals; Cell Differentiation; Fetus; Glycolysis; Hormones, Ectopic; Humans; Isoenzymes; Methylation; Neoplasms; Oxygen Consumption; Protein Biosynthesis; Pyruvate Kinase; Transcription, Genetic

1976
Serum levels of N2, N2-dimethylguanosine and pseudouridine as determined by radioimmunoassay for patients with malignancy.
    Journal of the National Cancer Institute, 1975, Volume: 54, Issue:2

    Topics: Antibody Specificity; Breast Neoplasms; Guanosine; Humans; Leukemia; Methylation; Neoplasms; Pseudouridine; Radioimmunoassay; Uridine

1975
DNA methylation of coding and non-coding regions of the human H-RAS gene in normal and tumor tissues.
    Oncogene, 1992, Volume: 7, Issue:2

    Topics: Alleles; Blotting, Southern; DNA, Neoplasm; Gene Expression Regulation; Genes, ras; Humans; Methylation; Neoplasms; Promoter Regions, Genetic; Proto-Oncogene Proteins p21(ras); Restriction Mapping; RNA, Messenger

1992
The O-methylation of 4-hydroxyestradiol is inhibited by 2-hydroxyestradiol: implications for estrogen-induced carcinogenesis.
    Carcinogenesis, 1990, Volume: 11, Issue:3

    Topics: Animals; Catechol O-Methyltransferase; Estradiol; Estrogens; Estrogens, Catechol; Hydrogen-Ion Concentration; Kinetics; Male; Methylation; Neoplasms; Rats; Rats, Inbred Strains

1990
Expression of chorionic gonadotropin alpha- and beta-genes in normal and neoplastic human tissues: relationship to deoxyribonucleic acid structure.
    Endocrinology, 1985, Volume: 117, Issue:1

    Topics: Cell Line; Chorionic Gonadotropin; Chorionic Gonadotropin, beta Subunit, Human; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Restriction Enzymes; Female; Glycoprotein Hormones, alpha Subunit; Humans; Lung Neoplasms; Lymphocytes; Methylation; Neoplasms; Nucleic Acid Hybridization; Peptide Fragments; Placenta; Polymorphism, Genetic; Pregnancy; Trophoblastic Neoplasms

1985
Induction of adipocyte formation in 10T1/2 cells by 1-methylguanine and 7-methylguanine.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 1985, Volume: 6, Issue:2

    Topics: Adipose Tissue; Animals; Azacitidine; Cell Differentiation; DNA; Guanine; Methylation; Mice; Neoplasms

1985
On the possible contribution of DNA hypomethylation to the induction of high frequency and heritable drug-induced alterations in the malignant phenotype.
    Progress in clinical and biological research, 1986, Volume: 212

    Topics: Alkylating Agents; Animals; Azacitidine; Cell Line; DNA, Neoplasm; Gene Amplification; Humans; Methylation; Mice; Mutagens; Mutation; Neoplasms; Neoplasms, Experimental; Phenotype; Thymidine Kinase

1986
Major histocompatibility complex DQ beta gene: polymorphism, methylation state and accumulation of messenger RNA in tumor cells.
    Bollettino della Societa italiana di biologia sperimentale, 1986, May-30, Volume: 62, Issue:5

    Topics: Base Sequence; Deoxyribonuclease HpaII; DNA; DNA Restriction Enzymes; HLA-D Antigens; HLA-DQ Antigens; Humans; Major Histocompatibility Complex; Methylation; Neoplasms; Polymorphism, Genetic; RNA, Messenger

1986
[Modification of the relative plasma concentrations of methyl and methylene groups in cancer: a study using proton NMR spectroscopy].
    Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1989, Volume: 309, Issue:10

    Topics: Humans; Lipoproteins; Magnetic Resonance Spectroscopy; Methylation; Neoplasms

1989
Proton nuclear magnetic resonance methyl and methylene linewidths from plasma decrease during postprandial lipemia.
    Biochimica et biophysica acta, 1989, Dec-18, Volume: 1006, Issue:3

    Topics: Chylomicrons; Dietary Fats; Female; Food; Humans; Kinetics; Lipids; Lipoproteins; Lipoproteins, VLDL; Magnetic Resonance Spectroscopy; Male; Methylation; Neoplasms; Triglycerides

1989
[NMR research on blood plasma for tumor detection--a method for mass screening?].
    Archiv fur Geschwulstforschung, 1989, Volume: 59, Issue:2

    Topics: Biomarkers, Tumor; Diagnosis, Differential; Evaluation Studies as Topic; Humans; Lipoproteins; Magnetic Resonance Spectroscopy; Mass Screening; Methylation; Neoplasms

1989
Methylation state of cellular genes and oncogenes as a marker of malignancy in human carcinomas.
    Tumori, 1989, Aug-31, Volume: 75, Issue:4

    Topics: DNA; Gene Amplification; HLA-DR Antigens; Humans; Methylation; Neoplasms; Pancreatic Neoplasms; Proto-Oncogenes; Tumor Cells, Cultured

1989
The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia.
    Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:15

    Topics: Calcitonin; Cell Line; Cell Transformation, Viral; Chromosomes, Human, Pair 11; Colonic Neoplasms; Deltaretrovirus; DNA; Fibroblasts; Gene Expression Regulation; Humans; Lung Neoplasms; Lymphocytes; Methylation; Neoplasms; Suppression, Genetic; Teratoma; Tumor Cells, Cultured

1988
Clonal analysis using recombinant DNA probes from the X-chromosome.
    Cancer research, 1987, Sep-15, Volume: 47, Issue:18

    Topics: Alleles; Base Sequence; DNA, Neoplasm; DNA, Recombinant; Female; Humans; Hypoxanthine Phosphoribosyltransferase; Methylation; Neoplasms; Phosphoglycerate Kinase; Polymorphism, Restriction Fragment Length; X Chromosome

1987
Cancer genetics. Genomic imprinting and embryonal tumours.
    Nature, 1989, Mar-09, Volume: 338, Issue:6211

    Topics: Alleles; Chromosome Deletion; Methylation; Models, Genetic; Mutation; Neoplasms

1989
Human DNA methylation: methylated DNA-binding protein, differentiation and cancer.
    Progress in clinical and biological research, 1985, Volume: 198

    Topics: Aging; Cell Differentiation; DNA; DNA Restriction Enzymes; DNA-Binding Proteins; Female; Fetus; Humans; Methylation; Neoplasms; Pregnancy

1985
Patterns of DNA methylation and gene expression in human tumor cell lines.
    Cancer research, 1986, Volume: 46, Issue:6

    Topics: Cell Line; Collagen; Cytosine; DNA, Neoplasm; Gene Expression Regulation; Humans; Methylation; Neoplasms; Polymorphism, Genetic; Proto-Oncogenes; Thymidine Kinase

1986
Methylation of ribosomal RNA as a possible factor in cell differentiation.
    Cancer research, 1987, Jan-01, Volume: 47, Issue:1

    Topics: Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Methylation; Neoplasms; Protein Biosynthesis; RNA, Ribosomal

1987
Genetic and epigenetic aspects of tumor progression and tumor heterogeneity.
    Basic life sciences, 1985, Volume: 33

    Topics: Animals; Cell Line; DNA; Humans; Methylation; Neoplasm Metastasis; Neoplasms; Oncogenes

1985
A simple technique for cell surface radioactive labeling of human and animal neoplastic cells: reductive methylation with formaldehyde and tritiated borohydride.
    Neoplasma, 1985, Volume: 32, Issue:4

    Topics: Animals; Borohydrides; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Electrophoresis; Formaldehyde; Humans; Isotope Labeling; Methylation; Neoplasm Proteins; Neoplasms; Rats; Tritium

1985
The molecular biology of human cancer.
    Progress in clinical and biological research, 1985, Volume: 198

    Topics: Chromosome Deletion; DNA; DNA, Neoplasm; Gene Amplification; Humans; Methylation; Mutation; Neoplasms

1985
Methionine metabolism and cancer.
    Nutrition and cancer, 1985, Volume: 7, Issue:3

    Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Diet; Gene Expression Regulation; Mammals; Methionine; Methylation; Methyltransferases; Models, Biological; Neoplasms; S-Adenosylmethionine

1985
Polyamines.
    Lancet (London, England), 1973, Volume: 2, Issue:7822

    Topics: Animals; Cell Differentiation; DNA-Directed RNA Polymerases; Humans; Mammals; Methylation; Neoplasms; Polyamines; Putrescine; RNA; RNA, Messenger; RNA, Transfer; Spermidine; Spermine

1973
[N-demethylation of the carcinogen dimethylnitrosamine by human embryonal tissue (author's transl)].
    Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology, 1974, Volume: 81, Issue:3-4

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Dimethylamines; Embryo, Mammalian; Female; Formaldehyde; Gestational Age; Guinea Pigs; Humans; In Vitro Techniques; Liver; Maternal-Fetal Exchange; Methylation; Microsomes, Liver; Neoplasms; Nitrosamines; Pregnancy; Rats; Species Specificity; Subcellular Fractions

1974
Methylation of RNA by mouse organs and tumors: ionic stimulation in vitro.
    Biochimica et biophysica acta, 1968, Apr-22, Volume: 157, Issue:2

    Topics: Adenocarcinoma; Animals; Animals, Newborn; Brain; Dialysis; Electrophoresis; Escherichia coli; Kidney; Leukemia Virus, Murine; Leukemia, Lymphoid; Leukemia, Radiation-Induced; Lung; Lung Neoplasms; Methylation; Mice; Neoplasm Transplantation; Neoplasms; Quaternary Ammonium Compounds; RNA, Bacterial; RNA, Transfer; Spleen; Splenic Neoplasms; Temperature; Transferases

1968
Use of mass spectrometry for the carbohydrate composition and sequence analysis of glycosphingolipids.
    Biomedical mass spectrometry, 1974, Volume: 1, Issue:1

    Topics: Carbohydrates; Ceramides; Fatty Acids; Gangliosides; Glycolipids; Hexosamines; Hexoses; Mass Spectrometry; Methylation; Molecular Weight; Neoplasms; Sialic Acids; Sphingolipids

1974
Is aberrant nucleic acid methylation related to malignant transformation?
    Journal of the National Cancer Institute, 1974, Volume: 53, Issue:5

    Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; Forecasting; Methylation; Methyltransferases; Mice; Models, Biological; Neoplasms; RNA, Neoplasm; RNA, Transfer

1974
Comparison of soluble RNA methylase capacity in paired neoplastic and nonneoplastic cell lines in vitro.
    Cancer research, 1969, Volume: 29, Issue:3

    Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell-Free System; Escherichia coli; Methionine; Methylation; Mice; Neoplasms; RNA, Neoplasm; RNA, Transfer; Transferases

1969
Transfer RNA methylases and cancer.
    Nature, 1970, Dec-26, Volume: 228, Issue:5278

    Topics: Animals; Carbon Isotopes; Carcinogens; Cell Differentiation; Chromatography, Ion Exchange; Escherichia coli; Ethionine; Guanine; Humans; Kidney Neoplasms; Liver Regeneration; Methionine; Methylation; Morphogenesis; Neoplasms; Nitrosamines; Phenylalanine; Protein Biosynthesis; Rats; Ribosomes; RNA, Bacterial; RNA, Messenger; RNA, Transfer; Transferases

1970
Altered transfer RNA methylase patterns in Marek's disease tumors.
    Cancer research, 1971, Volume: 31, Issue:5

    Topics: Animals; Carbon Isotopes; Cell Transformation, Neoplastic; Cell-Free System; Chickens; Escherichia coli; Kidney; Kidney Neoplasms; Liver; Liver Neoplasms; Lung; Methylation; Methyltransferases; Myocardium; Neoplasms; Neoplasms, Experimental; Nucleosides; Oncogenic Viruses; Poultry Diseases; RNA, Neoplasm; RNA, Transfer; Spleen; Transferases; Viruses, Unclassified

1971
Initiation of malignant transformation and the significance of changes in transfer RNA methylase enzymes.
    Cancer research, 1971, Volume: 31, Issue:5

    Topics: Animals; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Culture Techniques; Female; Kidney; Kidney Neoplasms; Male; Methylation; Methyltransferases; Mice; Neoplasms; Ovarian Neoplasms; Ovary; Prostate; Prostatic Neoplasms; RNA, Transfer; Transferases

1971
Transfer RNA and transfer RNA modification in differentiation and neoplasia. Introduction.
    Cancer research, 1971, Volume: 31, Issue:5

    Topics: Methylation; Neoplasms; RNA, Neoplasm; RNA, Transfer; Transferases

1971